                         SEQUENCE LISTING

<110>  UNIVERSITE DE GENEVE
 
<120>  METHODS FOR INDUCING INSULIN PRODUCTION AND USES THEREOF

<130>  P1775PC00

<150>  EP 14 175 042.2
<151>  2014-06-30

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  652
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Glu Ala Pro Gln Val Val Glu Thr Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Gln Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Asn Gln Ser Asn Ser Thr Thr Ser Ser Pro Ala Pro Ser Gly Gly Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Ser Leu Ala Ser Ala Ser Ala Val 
    50                  55                  60                  


Ser Thr Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser Glu Asp 
65                  70                  75                  80  


Phe Ala Arg Ala Pro Gly Cys Val Ala Val Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ser Arg Gly Leu Cys Gly Asp Phe Gln Gly Pro Glu Ala Gly Cys Val 
            100                 105                 110         


His Pro Ala Pro Pro Gln Pro Pro Pro Thr Gly Pro Leu Ser Gln Pro 
        115                 120                 125             


Pro Pro Val Pro Pro Ser Ala Ala Ala Ala Ala Gly Pro Leu Ala Gly 
    130                 135                 140                 


Gln Pro Arg Lys Thr Ser Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser Ala Glu Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys Ser Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser Met Asp Asn 
                245                 250                 255     


Asn Ser Lys Phe Ala Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ser Leu Gln Ser Gly Gln Glu Gly Pro Gly Asp Ser Pro Gly Ser Gln 
        275                 280                 285             


Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn Asp Asp Phe 
    290                 295                 300                 


Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn Ala Ser Thr 
305                 310                 315                 320 


Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp Asp Leu Gly 
                325                 330                 335     


Asp Gly Asp Val His Ser Leu Val Tyr Pro Pro Ser Ala Ala Lys Met 
            340                 345                 350         


Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro Glu Asn Met 
        355                 360                 365             


Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro Thr Ser Leu 
    370                 375                 380                 


Thr Val Ser Thr Gln Ser Ser Pro Gly Ser Met Met Gln Gln Thr Pro 
385                 390                 395                 400 


Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser Pro Ser Pro 
                405                 410                 415     


Asn Tyr Ser Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser Pro Leu Pro 
            420                 425                 430         


Gln Met Pro Met Gln Thr Leu Gln Asp Ser Lys Ser Ser Tyr Gly Gly 
        435                 440                 445             


Leu Asn Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu Leu Leu Thr 
    450                 455                 460                 


Ser Asp Ser Pro Pro His Asn Asp Ile Met Ser Pro Val Asp Pro Gly 
465                 470                 475                 480 


Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val Met Met Gly 
                485                 490                 495     


Pro Asn Ser Val Met Pro Ala Tyr Gly Ser Gln Ala Ser His Asn Lys 
            500                 505                 510         


Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala Gln Gln Thr 
        515                 520                 525             


Ala Ser Val Asn Gly Arg Thr Leu Pro His Val Val Asn Thr Met Pro 
    530                 535                 540                 


His Thr Ser Ala Met Asn Arg Leu Thr Pro Val Lys Thr Pro Leu Gln 
545                 550                 555                 560 


Val Pro Leu Ser His Pro Met Gln Met Ser Ala Leu Gly Ser Tyr Ser 
                565                 570                 575     


Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Val Leu His Gln 
            580                 585                 590         


Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu Arg Leu Asp 
        595                 600                 605             


Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp Gly Asp Thr 
    610                 615                 620                 


Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser Phe Pro His 
625                 630                 635                 640 


Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650         


<210>  2
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Ala Pro Gln Val Val Glu Ile Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Ser Gln Ser Asn Ser Ala Thr Ser Ser Pro Ala Pro Ser Gly Ser Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Gly Leu Pro Ser Ala Ser Ala Ala 
    50                  55                  60                  


Ala Val Ser Ala Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Pro Gln Ala Pro Gly Ser Val Ala Ala Ala Val Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Thr Gly Gly Leu Cys Gly Asp Phe Gln Gly 
            100                 105                 110         


Pro Glu Ala Gly Cys Leu His Pro Ala Pro Pro Gln Pro Pro Pro Pro 
        115                 120                 125             


Gly Pro Leu Ser Gln His Pro Pro Val Pro Pro Ala Ala Ala Gly Pro 
    130                 135                 140                 


Leu Ala Gly Gln Pro Arg Lys Ser Ser Ser Ser Arg Arg Asn Ala Trp 
145                 150                 155                 160 


Gly Asn Leu Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser 
                165                 170                 175     


Ala Glu Lys Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys 
            180                 185                 190         


Ser Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly 
        195                 200                 205             


Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile 
    210                 215                 220                 


Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn 
225                 230                 235                 240 


Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser 
                245                 250                 255     


Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys 
            260                 265                 270         


Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro 
        275                 280                 285             


Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn 
    290                 295                 300                 


Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn 
305                 310                 315                 320 


Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp 
                325                 330                 335     


Asp Leu Gly Glu Gly Asp Met His Ser Met Val Tyr Pro Pro Ser Ala 
            340                 345                 350         


Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro 
        355                 360                 365             


Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro 
    370                 375                 380                 


Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln 
385                 390                 395                 400 


Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser 
                405                 410                 415     


Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser 
            420                 425                 430         


Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser 
        435                 440                 445             


Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu 
    450                 455                 460                 


Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val 
465                 470                 475                 480 


Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val 
                485                 490                 495     


Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser 
            500                 505                 510         


His Asn Lys Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala 
        515                 520                 525             


Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser 
    530                 535                 540                 


Thr Met Pro His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr 
545                 550                 555                 560 


Pro Val Gln Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly 
                565                 570                 575     


Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu 
            580                 585                 590         


Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu 
        595                 600                 605             


Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp 
    610                 615                 620                 


Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser 
625                 630                 635                 640 


Phe Pro His Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650                 655 


<210>  3
<211>  5552
<212>  DNA
<213>  Mus musculus

<400>  3
aggggcgggg cggcgcgcgc gccgccgcgg gcggggagcc cgctgcagat cccgtaagac       60

gggagtctgc ggagtcgctt cagtccccgc cgccgccaca ttcaacaggc agcagcgccg      120

ctgtcgcgcg gccgcggaga gctagagcgg cccgcagcgt ccgcccgtct gccttggcgt      180

ccgcggccct tgtcagcggg agcgcggtgc ccgagctgcc gggctccgcg gcctggtcgg      240

tgccccgtcc taggcacgaa ctcggaggct ccttagacac cggtgaccca gcgaagttaa      300

gttctgggcg cgtccgtccg ctgcgccccg ccgcgcctga ctccggcgtg cgtccgccgt      360

ccgcggcccc ccaatctcgg agcgacactc gggtcgcccg ctccgcgccc ccggtggccg      420

cgtctcccgg tacttctctg ctggtggggg aggggcgggg gcaccatggc cgaagcgccc      480

caggtggtgg agaccgaccc ggacttcgag ccgctgcccc ggcagcgctc ctgtacctgg      540

ccgctgccca ggccggagtt taaccagtcc aactcgacca cctccagtcc ggcgccgtcg      600

ggcggcgcgg ccgccaaccc cgacgccgcg gcgagcctgg cctcggcgtc cgctgtcagc      660

accgacttta tgagcaacct gagcctgctg gaggagagtg aggacttcgc gcgggcgcca      720

ggctgcgtgg ccgtggcggc ggcggctgcg gccagcaggg gcctgtgcgg ggacttccag      780

ggccccgagg cgggctgcgt gcacccagcg ccgccacagc ccccaccgac cgggccgctg      840

tcgcagcccc cacccgtgcc tccctccgct gccgccgccg cggggccact cgcgggacag      900

ccgcgcaaga ccagctcgtc gcgccgcaac gcgtggggca acctgtcgta cgccgacctc      960

atcaccaagg ccatcgagag ctcagccgag aagaggctca ccctgtcgca gatctacgag     1020

tggatggtga agagcgtgcc ctacttcaag gataagggcg acagcaacag ctcggcgggc     1080

tggaagaatt caattcgcca caatctgtcc cttcacagca agtttattcg agtgcagaat     1140

gaaggaactg gaaagagttc ttggtggatg ctcaatccag agggaggcaa gagcggaaaa     1200

tcaccccgga gaagagctgc gtccatggac aacaacagta aatttgctaa gagccgaggg     1260

cgggctgcta agaaaaaagc atctctccag tctgggcaag agggtcctgg agacagccct     1320

gggtctcagt tttctaagtg gcctgcgagt cctgggtccc acagcaacga tgactttgat     1380

aactggagta catttcgtcc tcgaaccagc tcaaatgcta gtaccatcag tgggagactt     1440

tctcccatca tgacagagca ggatgacctg ggagatgggg acgtgcattc cctggtgtat     1500

ccaccctctg ctgccaagat ggcgtctacg ctgcccagtc tgtctgaaat cagcaatcca     1560

gaaaacatgg agaaccttct ggataatctc aaccttctct cgtccccaac atctttaact     1620

gtgtccaccc agtcctcgcc tggcagcatg atgcagcaga caccatgcta ttcgtttgca     1680

ccgccaaaca ccagtctaaa ttcacccagt ccaaactact caaagtacac atacggccaa     1740

tccagcatga gccctttgcc ccagatgcct atgcagacac ttcaggacag caaatcaagt     1800

tacggaggat tgaaccagta taactgtgcc ccaggactct tgaaagagtt gttgacttct     1860

gactctcctc cccacaatga cattatgtca ccggttgatc ccggagtggc ccaacccaac     1920

agtcgggtcc tgggccaaaa tgtaatgatg ggccctaatt cggtcatgcc agcgtatggc     1980

agccaggcat ctcataacaa aatgatgaac cccagctccc acacccaccc tggacatgca     2040

cagcaaacgg cttcggtcaa cggccgtacc ctgccccatg tggtgaacac catgcctcac     2100

acatctgcca tgaaccgctt gacccccgtg aagacacctt tacaagtgcc tctgtcccac     2160

cccatgcaga tgagtgccct gggcagctac tcctcggtga gcagctgcaa tggctatggt     2220

aggatgggtg tcctccacca ggagaagctc ccaagtgact tggatggcat gtttattgag     2280

cgcttggact gtgacatgga gtccatcatt cggaatgacc tcatggatgg agataccttg     2340

gattttaact ttgataatgt gttgcccaac caaagcttcc cacacagtgt caagactaca     2400

acacacagct gggtgtcagg ctaagagtta gtgagcaggc tacatttaaa agtccttcag     2460

attgtctgac agcaggaact gaggagcagt ccaaagatgc ccttcacccc tccttatagt     2520

tttcaagatt taaaaaaaaa aaaaaaaaaa aaaaaagtcc tttctccttt cctcagactt     2580

ggcaacagcg gcagcacttt cctgtgcagg atgtttgccc agcgtccgca ggttttgtgc     2640

tcctgtagat aaggactgtg ccattgggaa tcattacaat gaagtgccaa actcactaca     2700

ccatgtaatt gcagaaaaga ctttcagatc ctggagtgct ttcaagtttt gtatatatgc     2760

agtagataca gaattgtatt tgtgtgtgtg ttttttaata cctacttggt ccaaggaaag     2820

tttatactct tttgtaatac tgtgatggtc tcaagtcttg ataaactttg ctttgtacta     2880

cctgtgttct gctacagtga gaagtcatga actaagatct ctgtcctgca cctcggctga     2940

atgactgaac ctggtcattt gccacagaac ccatgagagc caagtagcca gtgatcaatg     3000

tgctgaatta atggacttgt caaactttgg ggcagaataa gattaagtgc cagctttgta     3060

caggtctttt tctattgttt ttgttgttgt ttattttgtt atttgcaaat ttgtacaaac     3120

aacttaaaat ggttctaatt tccagataaa tgacttttga tgttattgtt aggactcaac     3180

atcttttgga atagataccg aagtgtaatg ttttcttaaa actagagtct actttgttac     3240

attgtctgct tataaatttg tgaaatcaga ggtatttggg ggctgcattc ataattttca     3300

ttttgtattt ctaactggat tagtactaat tttatatgtg ctcagctggt ttgtacactt     3360

tgcgatgata cctgataatg tttctgacta atcgtaaacc attgtaatta gtacttgcac     3420

actcaacgtt cctggccctt tgggcaggaa agttatgtat agttacagac actctgtttt     3480

gtgtgtagat ttatgtgtgt attttaaaga aatttcacct gcttttatta ccctgtgagt     3540

tgtgtacagc gcatagcacc aagtcttcag atagatgcca cgtgcttaca gccttctagg     3600

gaagcctgcc agatgatgcc ctgtgtcacg ctgtcatagt tcccatggga actctgtctg     3660

tcgctcagga aaggggaact tttatctaag gtgatgttct ttgtctgact ggggttcgcc     3720

tcctactact ctgagctgtt ggcttttgtc acgatggagg tggctttgtg gctctgtcct     3780

gaagaatcct gtcacttctc ggtccccacc tctgttctct ttggctctga acagtgtaaa     3840

tctaaggagg aagtttacaa ataggacttc agtgatttat ggagtgctct gtgcgcctaa     3900

gtacagacag tggcaggatt agttaaaaat gaaggcagta aacttggaaa ccagccagct     3960

ataaatggac atttattttg aaatccttag cttaagaatt tgagaagttt tttcagcctt     4020

gagcagccta atgtgtctca aacatttacg ttttttatac attctattta cctgaaatcc     4080

tgccagacca ggataattgg ttttacctct cattccgtcc atcggtgttt cccagtctcc     4140

cacagtttga ggaatagatg taccccagca cccctctttg cctttatgag aaggcctggt     4200

ttgcatgaga agaccaaatt gcacttccat gagaagacca aattgtttgt agtgttactt     4260

agctctcccc tcgtttgtta gtgtgtgtta acaagaataa aatgtccctg ctttcaccca     4320

ccgttggcca gctttgtcat aggcttccca ccataacttt cactatttta aacacatatt     4380

gagccactgc tcgtctgact acctttgttt gggcactcca aaacaggact tgttttagaa     4440

atgaactcct ccaagtagag cctccttcaa acagagtaga atttcctggt gtcaaagaac     4500

ccgggtctgt ctccctttcc tcctccctct gccatttctt accattgcgg aaagagagag     4560

cctccgtgtg taatcattca gtagaggcag ctaccgccct ggcagtggtc tacctgctga     4620

atgccactga atgactagga ggtgtctctc ccttcagaag ctgtcaattt cagcagcaac     4680

ccctgttttc cttggtgtta agatcccagt gtgaatcatg ggcagttgtc tggggcacag     4740

tgaactccag gaaaggcttc gtatctgttt tgaaaacaaa catcaaacgt gtgagctccg     4800

agggtccttt tctgggagaa tgttcgcttt ctggtctatt attgtacatg attgctctgt     4860

gaaaagactt catctatgca gccttgtttg attcatttcc tttggtgtgt tctgttgtta     4920

agagcaaatt gtattataga gctatttgga tattttaaat ataaagatgt attgtttcca     4980

taatatagat gtatggagta tatttaggtg atagatgtac aacttggaaa gttctgcttg     5040

gacaaactga gtctaagtta attagcaaat aatatatcct gatgagcagg aagccctgaa     5100

acctaacaac agtaagcgga gaaaatcact taaaatggaa acagttcccc aaaggtgttc     5160

aatttgaact tgttcaactg cttaatatat ggtccccccc ccccccaaaa aaaaaacctt     5220

gaagttctta gttttcagct ctccaagtta ctgattttaa gtgaagtttc tctgtggttt     5280

cagctgggga gtgattgttc agtagagtgt gcattgtgct ttatgcaaac caaacagcct     5340

ggccctgtgg ccggggacag acagacagcc cgtcaggata gagtcccgcc cttcgccacc     5400

acagcggact tgagtaacag tgcagatgcc ttgctcctgt tccattgcta tctgagaagt     5460

gcctgatgag gatggtaaac ttacagacac aagaacaatc cttactgtgc gttgtataaa     5520

gccataaatg tacataaatc atcttaagtg gc                                   5552


<210>  4
<211>  5738
<212>  DNA
<213>  Homo sapiens

<400>  4
gcagccgcca cattcaacag gcagcagcgc agcgggcgcg ccgctgggga gagcaagcgg       60

cccgcggcgt ccgtccgtcc ttccgtccgc ggccctgtca gctggagcgc ggcgcaggct      120

ctgccccggc ccggcggctc tggccggccg tccagtccgt gcggcggacc ccgaggagcc      180

tcgatgtgga tggccccgcg aagttaagtt ctgggctcgc gcttccactc cgccgcgcct      240

tcctcccagt ttccgtccgc tcgccgcacc ggcttcgttc ccccaaatct cggaccgtcc      300

cttcgcgccc cctccccgtc cgcccccagt gctgcgttct ccccctcttg gctctcctgc      360

ggctggggga ggggcggggg tcaccatggc cgaggcgcct caggtggtgg agatcgaccc      420

ggacttcgag ccgctgcccc ggccgcgctc gtgcacctgg ccgctgccca ggccggagtt      480

tagccagtcc aactcggcca cctccagccc ggcgccgtcg ggcagcgcgg ctgccaaccc      540

cgacgccgcg gcgggcctgc cctcggcctc ggctgccgct gtcagcgccg acttcatgag      600

caacctgagc ttgctggagg agagcgagga cttcccgcag gcgcccggct ccgtggcggc      660

ggcggtggcg gcggcggccg ccgcggccgc caccgggggg ctgtgcgggg acttccaggg      720

cccggaggcg ggctgcctgc acccagcgcc accgcagccc ccgccgcccg ggccgctgtc      780

gcagcacccg ccggtgcccc ccgccgccgc tgggccgctc gcggggcagc cgcgcaagag      840

cagctcgtcc cgccgcaacg cgtggggcaa cctgtcctac gccgacctca tcaccaaggc      900

catcgagagc tcggcggaga agcggctcac gctgtcgcag atctacgagt ggatggtcaa      960

gagcgtgccc tacttcaagg ataagggtga cagcaacagc tcggcgggct ggaagaattc     1020

aattcgtcat aatctgtccc tacacagcaa gttcattcgt gtgcagaatg aaggaactgg     1080

aaaaagttct tggtggatgc tcaatccaga gggtggcaag agcgggaaat ctcctaggag     1140

aagagctgca tccatggaca acaacagtaa atttgctaag agccgaagcc gagctgccaa     1200

gaagaaagca tctctccagt ctggccagga gggtgctggg gacagccctg gatcacagtt     1260

ttccaaatgg cctgcaagcc ctggctctca cagcaatgat gactttgata actggagtac     1320

atttcgccct cgaactagct caaatgctag tactattagt gggagactct cacccattat     1380

gaccgaacag gatgatcttg gagaagggga tgtgcattct atggtgtacc cgccatctgc     1440

cgcaaagatg gcctctactt tacccagtct gtctgagata agcaatcccg aaaacatgga     1500

aaatcttttg gataatctca accttctctc atcaccaaca tcattaactg tttcgaccca     1560

gtcctcacct ggcaccatga tgcagcagac gccgtgctac tcgtttgcgc caccaaacac     1620

cagtttgaat tcacccagcc caaactacca aaaatataca tatggccaat ccagcatgag     1680

ccctttgccc cagatgccta tacaaacact tcaggacaat aagtcgagtt atggaggtat     1740

gagtcagtat aactgtgcgc ctggactctt gaaggagttg ctgacttctg actctcctcc     1800

ccataatgac attatgacac cagttgatcc tggggtagcc cagcccaaca gccgggttct     1860

gggccagaac gtcatgatgg gccctaattc ggtcatgtca acctatggca gccaggcatc     1920

tcataacaaa atgatgaatc ccagctccca tacccaccct ggacatgctc agcagacatc     1980

tgcagttaac gggcgtcccc tgccccacac ggtaagcacc atgccccaca cctcgggtat     2040

gaaccgcctg acccaagtga agacacctgt acaagtgcct ctgccccacc ccatgcagat     2100

gagtgccctg gggggctact cctccgtgag cagctgcaat ggctatggca gaatgggcct     2160

tctccaccag gagaagctcc caagtgactt ggatggcatg ttcattgagc gcttagactg     2220

tgacatggaa tccatcattc ggaatgacct catggatgga gatacattgg attttaactt     2280

tgacaatgtg ttgcccaacc aaagcttccc acacagtgtc aagacaacga cacatagctg     2340

ggtgtcaggc tgagggttag tgagcaggtt acacttaaaa gtacttcaga ttgtctgaca     2400

gcaggaactg agagaagcag tccaaagatg tctttcacca actccctttt agttttcttg     2460

gttaaaaaaa aaaacaaaaa aaaaaaccct ccttttttcc tttcgtcaga cttggcagca     2520

aagacatttt tcctgtacag gatgtttgcc caatgtgtgc aggttatgtg ctgctgtaga     2580

taaggactgt gccattggaa atttcattac aatgaagtgc caaactcact acaccatata     2640

attgcagaaa agattttcag atcctggtgt gctttcaagt tttgtatata agcagtagat     2700

acagattgta tttgtgtgtg tttttggttt ttctaaatat ccaattggtc caaggaaagt     2760

ttatactctt tttgtaatac tgtgatgggc ctcatgtctt gataagttaa acttttgttt     2820

gtactacctg ttttctgcgg aactgacgga tcacaaagaa ctgaatctcc attctgcatc     2880

tccattgaac agccttggac ctgttcacgt tgccacagaa ttcacatgag aaccaagtag     2940

cctgttatca atctgctaaa ttaatggact tgttaaactt ttggaaaaaa aaagattaaa     3000

tgccagcttt gtacaggtct tttctatttt tttttgttta ttttgttatt tgcaaatttg     3060

tacaaacatt taaatggttc taatttccag ataaatgatt tttgatgtta ttgttgggac     3120

ttaagaacat ttttggaata gatattgaac tgtaataatg ttttcttaaa actagagtct     3180

actttgttac atagtcagct tgtaaatttt gtggaaccac aggtatttgg ggcagcattc     3240

ataattttca ttttgtattc taactggatt agtactaatt ttatacatgc ttaactggtt     3300

tgtacacttt gggatgctac ttagtgatgt ttctgactaa tcttaaatca ttgtaattag     3360

tacttgcata ttcaacgttt caggccctgg ttgggcagga aagtgatgta tagttatgga     3420

cactttgcgt ttcttattta ggataactta atatgttttt atgtatgtat tttaaagaaa     3480

tttcatctgc ttctactgaa ctatgcgtac tgcatagcat caagtcttct ctagagacct     3540

ctgtagtcct gggaggcctc ataatgtttg tagatcagaa aagggagatc tgcatctaaa     3600

gcaatggtcc tttgtcaaac gagggatttt gatccacttc accattttga gttgagcttt     3660

agcaaaagtt tcccctcata attctttgct cttgtttcag tccaggtgga ggttggtttt     3720

gtagttctgc cttgaggaat tatgtcaaca ctcatacttc atctcattct cccttctgcc     3780

ctgcagatta gattacttag cacactgtgg aagtttaagt ggaaggaggg aatttaaaaa     3840

tgggacttga gtggtttgta gaatttgtgt tcataagttc agatgggtag caaatggaat     3900

agaacttact taaaaattgg ggagatttat ttgaaaacca gctgtaagtt gtgcattgag     3960

attatgttaa aagccttggc ttaagaattt gaaaatttct ttagcctgta gcaacctaaa     4020

ctgtaattcc tatcattatg ttttattact ttccaattac ctgtaactga cagaccaaat     4080

taattggctt tgtgtcctat ttagtccatc agtattttca agtcatgtgg aaagcccaaa     4140

gtcatcacaa tgaagagaac aggtgcacag cactgttcct cttgtgttct tgagaaggat     4200

ctaatttttc tgtatatagc ccacatcaca cttgctttgt cttgtatgtt aattgcatct     4260

tcattggctt ggtatttcct aaatgtttaa caagaacaca agtgttcctg ataagatttc     4320

ctacagtaag ccagctctat tgtaagcttc ccactgtgat gatcattttt ttgaagattc     4380

attgaacagc caccactcta tcatcctcat tttggggcag tccaagacat agctggtttt     4440

agaaacccaa gttcctctaa gcacagcctc ccgggtatgt aactgaactt ggtgccaaag     4500

tacttgtgta ctaatttcta ttactacgta ctgtcacttt cctcccgtgc cattactgca     4560

tcataataca aggaacctca gagcccccat ttgttcatta aagaggcaac tacagccaaa     4620

atcactgtta aaatcttact acttcatgga gtagctctta ggaaaatata tcttcctcct     4680

gagtctgggt aattatacct ctcccaagcc cccattgtgt gttgaaatcc tgtcatgaat     4740

ccttggtagc tctctgagaa cagtgaagtc cagggaaagg catctggtct gtctggaaag     4800

caaacattat gtggcctctg gtagtttttt tcctgtaaga atactgactt tctggagtaa     4860

tgagtatata tcagttattg tacatgattg ctttgtgaaa tgtgcaaatg atatcaccta     4920

tgcagccttg tttgatttat tttctctggt ttgtactgtt attaaaagca tattgtatta     4980

tagagctatt cagatatttt aaatataaag atgtattgtt tccgtaatat agacgtatgg     5040

aatatattta ggtaatagat gtattacttg gaaagttctg ctttgacaaa ctgacaaagt     5100

ctaaatgagc acatgtatcc cagtgagcag taaatcaatg gaacatccca agaagaggat     5160

aaggatgctt aaaatggaaa tcattctcca acgatataca aattggactt gttcaactgc     5220

tggatatatg ctaccaataa ccccagcccc aacttaaaat tcttacattc aagctcctaa     5280

gagttcttaa tttataacta attttaaaag agaagtttct tttctggttt tagtttggga     5340

ataatcattc attaaaaaaa atgtattgtg gtttatgcga acagaccaac ctggcattac     5400

agttggcctc tccttgaggt gggcacagcc tggcagtgtg gccaggggtg gccatgtaag     5460

tcccatcagg acgtagtcat gcctcctgca tttcgctacc cgagtttagt aacagtgcag     5520

attccacgtt cttgttccga tactctgaga agtgcctgat gttgatgtac ttacagacac     5580

aagaacaatc tttgctataa ttgtataaag ccataaatgt acataaatta tgtttaaatg     5640

gcttggtgtc tttcttttct aattatgcag aataagctct ttattaggaa ttttttgtga     5700

agctattaaa tacttgagtt aagtcttgtc agccacaa                             5738


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  5
aaggccaacc gtgaaaagat                                                   20


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  6
gtggtacgac cagagggata c                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  7
cagattgatg gctctttctc g                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  8
agacaaatcg ctccaccaac                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  9
aggtagctgt caacaaggca                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  10
cttgccgagg agtttgagat                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  11
cgaagtgtgg tatcctggtg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  12
ggtactgtcc aaacgcatgt                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  13
ttttctagga gcagcggtgt                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  14
agtggaaaag agcctgccaa                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  15
catcgaggtg agtgtcaagg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  16
cagacacgca ccacttcttt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  17
ggactagcaa gagcctttgg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  18
aagaatttca ggtgctcggt                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  19
agtctcatgg tgtggtggaa                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  20
gacatcacca ggattggaca                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  21
agtgtccagg gatgaggaag                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  22
cttctgttct gttggccctt                                                   20


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  23
aatcagccag ccttcgac                                                     18


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  24
atcactggga aggtatcgct                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  25
tccatgaacc agaacctcac                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  26
ggcttcattt ctttggcttc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  27
gcctcaatga tgggcttatt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  28
aaagcctggc actctctttg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  29
gagaagaggc tcaccctgtc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  30
acagattgtg gcgaattgaa                                                   20


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  31
tccatgacaa ctttggcatt g                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  32
cagtcttctg ggtggcagtg a                                                 21


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  33
gaggagaacc ccagatcatt cc                                                22


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  34
tgtgagtggc gtttgtcttc a                                                 21


<210>  35
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  35
ctcgtggcgc tgatgct                                                      17


<210>  36
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  36
ctggttgaat agtaaaatat cccattga                                          28


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  37
tcaacatggc cctgtggat                                                    19


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  38
aaaggtgctg cttgaaaaag c                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  39
ggaggtcatc cgactgaaac a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  40
gcacctctcg ctctccagaa t                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  41
tgagctagag ggaggaagga                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  42
ccgggtttct ctaactctgc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  43
gtcgggagaa ctaggatggc                                                   20


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  44
ggagcagtcc ctaggtatg                                                    19


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  45
agagagcacg cttggcctat tc                                                22


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  46
gtcgtcagag ttcgggtcca g                                                 21


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  47
ggacaaggct cccagtgtgt                                                   20


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  48
gcaagctctg gtcttccttg aa                                                22


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  49
tggagttgca tataattcca aagtt                                             25


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  50
ctagcctcaa tggcatcagt t                                                 21


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  51
gcccgggtgt aggcagtac                                                    19


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  52
cagtgggcag gaggtgctta                                                   20


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  53
taaaagttca gacctttggg cc                                                22


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  54
tcccggctct gaatggtg                                                     18


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  55
ctctccccca aaccccatat                                                   20


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  56
tttctaatgc agggtcaagt tgag                                              24


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  57
gaaagcttca gctctttccg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  58
aggccttcca ggcttagatt                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  59
gcacagccac catgaattac                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  60
ggaggtagaa ctggcgtctc                                                   20


<210>  61
<211>  672
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ala Glu Ala Pro Ala Ser Pro Val Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Asp Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Ser Ser Ala Met Val Ile Gly 
65                  70                  75                  80  


Gly Gly Val Ser Ser Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp Ser 
                85                  90                  95      


Ala Met Leu Leu Ala Pro Gly Gly Gln Asp Leu Gly Ser Gly Pro Ala 
            100                 105                 110         


Ser Ala Ala Gly Ala Leu Ser Gly Gly Thr Pro Thr Gln Leu Gln Pro 
        115                 120                 125             


Gln Gln Pro Leu Pro Gln Pro Gln Pro Gly Ala Ala Gly Gly Ser Gly 
    130                 135                 140                 


Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu Ser 
145                 150                 155                 160 


Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys Arg 
                165                 170                 175     


Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro Tyr 
            180                 185                 190         


Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn Ser 
        195                 200                 205             


Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln Asn 
    210                 215                 220                 


Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly Gly 
225                 230                 235                 240 


Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn Ser 
                245                 250                 255     


Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala Ala 
            260                 265                 270         


Leu Gln Ala Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu Ser 
        275                 280                 285             


Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp Ala 
    290                 295                 300                 


Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val Ser 
305                 310                 315                 320 


Gly Arg Leu Ser Pro Ile Leu Ala Ser Thr Glu Leu Asp Asp Val Gln 
                325                 330                 335     


Asp Asp Asp Gly Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala Ser 
            340                 345                 350         


Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg Leu 
        355                 360                 365             


Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Ala Glu Asn 
    370                 375                 380                 


Leu Met Asp Asp Leu Leu Asp Asn Ile Ala Leu Pro Pro Ser Gln Pro 
385                 390                 395                 400 


Ser Pro Pro Gly Gly Leu Met Gln Arg Gly Ser Ser Phe Pro Tyr Thr 
                405                 410                 415     


Ala Lys Ser Ser Gly Leu Gly Ser Pro Thr Gly Ser Phe Asn Ser Thr 
            420                 425                 430         


Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met Gln 
        435                 440                 445             


Thr Ile Gln Glu Asn Arg Pro Ala Thr Phe Ser Ser Val Ser His Tyr 
    450                 455                 460                 


Gly Asn Gln Thr Leu Gln Asp Leu Leu Ala Ser Asp Ser Leu Ser His 
465                 470                 475                 480 


Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala Ser 
                485                 490                 495     


Thr Ala Val Ser Ala Gln Asn Ala Arg Arg Asn Val Met Leu Arg Asn 
            500                 505                 510         


Asp Pro Met Met Ser Phe Ala Ala Gln Pro Thr Gln Gly Ser Leu Val 
        515                 520                 525             


Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu Gly 
    530                 535                 540                 


Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser Asp 
545                 550                 555                 560 


Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Ala Ser 
                565                 570                 575     


Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu Tyr 
            580                 585                 590         


Ser Ala Ser Ala Asn Leu Pro Val Met Gly His Asp Lys Phe Pro Ser 
        595                 600                 605             


Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met Glu 
    610                 615                 620                 


Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe Asn 
625                 630                 635                 640 


Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val Gly 
                645                 650                 655     


Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro Gly 
            660                 665                 670         


<210>  62
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Glu Ala Pro Ala Ser Pro Ala Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Gly Ser Ala Met Ala Ile Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp 
                85                  90                  95      


Ser Ala Arg Val Leu Ala Pro Gly Gly Gln Asp Pro Gly Ser Gly Pro 
            100                 105                 110         


Ala Thr Ala Ala Gly Gly Leu Ser Gly Gly Thr Gln Ala Leu Leu Gln 
        115                 120                 125             


Pro Gln Gln Pro Leu Pro Pro Pro Gln Pro Gly Ala Ala Gly Gly Ser 
    130                 135                 140                 


Gly Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn 
                245                 250                 255     


Ser Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ala Leu Gln Thr Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu 
        275                 280                 285             


Ser Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp 
    290                 295                 300                 


Ala Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val 
305                 310                 315                 320 


Ser Gly Arg Leu Ser Pro Ile Met Ala Ser Thr Glu Leu Asp Glu Val 
                325                 330                 335     


Gln Asp Asp Asp Ala Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala 
            340                 345                 350         


Ser Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg 
        355                 360                 365             


Leu Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Thr Glu 
    370                 375                 380                 


Asn Leu Met Asp Asp Leu Leu Asp Asn Ile Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Pro Ser Pro Thr Gly Gly Leu Met Gln Arg Ser Ser Ser Phe Pro Tyr 
                405                 410                 415     


Thr Thr Lys Gly Ser Gly Leu Gly Ser Pro Thr Ser Ser Phe Asn Ser 
            420                 425                 430         


Thr Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met 
        435                 440                 445             


Gln Thr Ile Gln Glu Asn Lys Pro Ala Thr Phe Ser Ser Met Ser His 
    450                 455                 460                 


Tyr Gly Asn Gln Thr Leu Gln Asp Leu Leu Thr Ser Asp Ser Leu Ser 
465                 470                 475                 480 


His Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala 
                485                 490                 495     


Ser Thr Ala Val Ser Ala Gln Asn Ser Arg Arg Asn Val Met Leu Arg 
            500                 505                 510         


Asn Asp Pro Met Met Ser Phe Ala Ala Gln Pro Asn Gln Gly Ser Leu 
        515                 520                 525             


Val Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu 
    530                 535                 540                 


Gly Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser 
545                 550                 555                 560 


Glu Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Val 
                565                 570                 575     


Ser Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu 
            580                 585                 590         


Tyr Ser Thr Ser Ala Asn Leu Pro Val Met Gly His Glu Lys Phe Pro 
        595                 600                 605             


Ser Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met 
    610                 615                 620                 


Glu Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe 
625                 630                 635                 640 


Asn Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val 
                645                 650                 655     


Gly Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro 
            660                 665                 670         


Gly 
    


<210>  63
<211>  2889
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (2580)..(2580)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2748)..(2748)
<223>  n is a, c, g, or t

<400>  63
gctccctgtg agtggctata actttgtgct gctgccgcgg ccgccctgct cgtggaaggg       60

aggaggagga atgtggaagg cggcggcgca gcacaggctg acaggcggtt cctccggcgg      120

gctgcggcgg cggcccgaga gtcccctcgt cgcggtgccc tgggctcgcg cggaatcgta      180

cgccctcccg cctcgttcct gaagggaagg agccgagctg gagctcgaac cttcgcggtg      240

ccccgttcct cccccgccgc acccagcctg ggctcgagag gagagagcaa gagcccaagc      300

cgcgggcggc gggcaggcgg cgaagatggc agaggcacca gcctccccgg tcccgctctc      360

tccgctcgaa gtggagctgg acccagagtt cgagccacag agtcggccac gctcctgtac      420

gtggcccctg cagaggccgg agctgcaggc gagcccggcc aagccctcgg gggagacggc      480

cgcagactcc atgatccccg aggaggacga cgatgaagac gacgaggacg gcggcggccg      540

agccagctcg gccatggtga tcggtggcgg cgtgagcagc acgctgggtt ccgggctgct      600

cctcgaggat tcggccatgc tgctggctcc aggagggcag gacctcgggt cggggccagc      660

gtccgccgca ggcgctctga gtgggggcac gccgacgcag ctgcagcctc agcagccact      720

gccacagccg cagccggggg cggctggggg ctctgggcaa ccaaggaaat gctcctcgcg      780

gcggaatgcc tgggggaacc tgtcctatgc cgacctgatc acccgcgcca tcgagagctc      840

cccggacaaa cggctcactt tgtcccagat ctacgagtgg atggtgcgct gtgtgcccta      900

cttcaaggat aagggcgaca gcaacagctc tgcgggctgg aagaactcca tccggcacaa      960

cctgtccctg cacagccgct tcatgcgcgt tcagaatgaa ggcacgggca agagctcttg     1020

gtggatcatc aaccccgatg ggggaaagag cgggaaggcc ccccggcggc gtgcggtctc     1080

catggacaac agcaacaagt acaccaagag ccgaggccgg gcagccaaga agaargcggc     1140

cctgcaggct gccccagagt cggcagacga cagtccttcc cagctctcca agtggcctgg     1200

cagccccacg tcccgcagca gcgacgagct ggatgcgtgg accgacttcc gctcgcgcac     1260

caattccaac gccagcaccg tgagcggccg cctgtcgccc atcctggcaa gcacggagct     1320

ggatgacgtc caggatgatg atggacccct gtcccccatg ctgtacagca gctctgccag     1380

cctgtcgccc tccgtgagca agccgtgtac tgtggagctt ccgcggctga cggacatggc     1440

cggcaccatg aatctgaatg atgggctggc cgagaacctc atggacgacc tgctggataa     1500

catcgcgctc ccgccatcgc agccatcgcc tcctggcggg cttatgcagc ggggctccag     1560

cttcccatat accgccaaga gctccggcct gggctcccca accggctcct tcaacagtac     1620

cgtgtttgga ccttcgtctc tgaactcctt gcgtcagtca cccatgcaga ctatccagga     1680

gaacagacca gccaccttct cttccgtgtc acactacggc aaccagacac tccaagacct     1740

gcttgcttca gactcactca gccacagcga cgtcatgatg acccagtcgg accccttgat     1800

gtctcaggct agcaccgccg tgtccgccca gaatgcccgc cggaacgtga tgcttcgcaa     1860

cgatccaatg atgtcctttg ctgcccagcc tacccagggg agtttggtca atcagaactt     1920

gctccaccac cagcaccaaa cccagggcgc tcttggtggc agccgtgcct tgtcaaattc     1980

tgtcagcaac atgggcttga gtgactccag cagccttggc tcagccaaac accagcagca     2040

gtctcccgcc agccagtcta tgcaaaccct ctcggactct ctctcaggct cctcactgta     2100

ttcagctagt gcaaaccttc ccgtcatggg ccacgataag ttccccagtg acttggacct     2160

ggacatgttc aatgggagct tggaatgtga catggagtcc atcatccgta gtgaactcat     2220

ggatgctgac gggttggatt ttaactttga ctccctcatc tccacacaga acgttgttgg     2280

tttgaatgtg gggaacttca ctggtgctaa gcaggcctca tctcaaagct gggtaccagg     2340

ctgaaggatc actgaggaaa ggggaaatgg gcaaagcaga ccctcaaact gacggragac     2400

ctacagagra aaccctttgc caaatytgct ytcagcaagt ggacagtgat ccgtttacag     2460

cttgacacct ttgagactcc cacgccgctt ccctaaccca gcagagactg ttagcagccc     2520

tggccctggg tgaagccctt acccgtggaa cagaacttta taacatatgc aaaatctaan     2580

tcatctgcaa gtgacctgcc agcgtggaca gcacccatca gcacccccca ctctttcaga     2640

gcacaccggg accccgttgg cgactccgtc gtgttttact atcatgatgg tttaggggat     2700

attttaagtg tcgtcttgtg tttgtttcct ttgaccctct gagttttnta cacacagtaa     2760

cctgcagtat ttttctgttg aaaatgttaa ctgtcctttc cctagcacac ttaaaagcag     2820

aaggaaggtg ttatatcagt tcccagtctg gccttgagca tcgcaagctt ttgagcctgt     2880

gggacccca                                                             2889


<210>  64
<211>  3183
<212>  DNA
<213>  Homo sapiens

<400>  64
actcgctccc tcccccggat cccgactggg aagggggcgg aggggacgac gtccgcgaga       60

atgcaaacca cacaaaaccc cgaagtggcc gtccccgccg ggctcgaacc tctgcgaaca      120

cccgctgggc tgctgctccc ccttctttct gtctttcctt tattttttgg aagtgacaag      180

ggcccatctg cgcccagacc cccgttcgcc ctctggcccg cgggcgaaga ggggagaggg      240

agctgcccgc gcagtccccg ggctcgggcc attcgaccgg gtggggggtg acggggggtc      300

gcggaggcgg ccaggctagg aaaggggaga agagccgaag acagcacaga cttgagcggc      360

ggcgccgcgg gaggcactag agcgggcccg agcgaaacat aaacaaacgc acgcacaccc      420

gagctcgggc tctgaccgcg gctcggctgc gccagctccg gccgctgccc gctttaaagg      480

cgcggccgcc cctcccccgg gcgcccctcc cccttctccc cgccccgccg cctagcccgg      540

gagggacctg cggctgggcg gcggggggag ggggctgccc cgcgcgaggc cgtcgattcg      600

ctcgcggctc catcgcggcc tggccggggg gcggtgtctg ctgcgccagg ttcgctggcc      660

gcacgtcttc aggtcctcct gttcctggga ggcgggcgcg gcaggactgg gaggtggcgg      720

cagcgggcga ggactcgccg aggacggggc tccggcccgg gataaccaac tctccttctc      780

tcttctttgg tgcttcccca ggcggcggcg gcggcgcccg ggagccggag ccttcgcggc      840

gtccacgtcc ctcccccgct gcaccccgcc ccggcgcgag aggagagcgc gagagcccca      900

gccgcgggcg ggcgggcggc gaagatggca gaggcaccgg cttccccggc cccgctctct      960

ccgctcgaag tggagctgga cccggagttc gagccccaga gccgtccgcg atcctgtacg     1020

tggcccctgc aaaggccgga gctccaagcg agccctgcca agccctcggg ggagacggcc     1080

gctgactcca tgatccccga ggaggaggac gatgaagacg acgaggacgg cgggggacgg     1140

gccggctcgg ccatggcgat cggcggcggc ggcgggagcg gcacgctggg ctccgggctg     1200

ctccttgagg actcggcccg ggtgctggca cccggagggc aagaccccgg gtctgggcca     1260

gccaccgcgg cgggcgggct gagcgggggt acacaggcgc tgctgcagcc tcagcaaccg     1320

ctgccaccgc cgcagccggg ggcggctggg ggctccgggc agccgaggaa atgttcgtcg     1380

cggcggaacg cctggggaaa cctgtcctac gcggacctga tcacccgcgc catcgagagc     1440

tccccggaca aacggctcac tctgtcccag atctacgagt ggatggtgcg ttgcgtgccc     1500

tacttcaagg ataagggcga cagcaacagc tctgccggct ggaagaactc catccggcac     1560

aacctgtcac tgcatagtcg attcatgcgg gtccagaatg agggaactgg caagagctct     1620

tggtggatca tcaaccctga tggggggaag agcggaaaag ccccccggcg gcgggctgtc     1680

tccatggaca atagcaacaa gtataccaag agccgtggcc gcgcagccaa gaagaaggca     1740

gccctgcaga cagcccccga atcagctgac gacagtccct cccagctctc caagtggcct     1800

ggcagcccca cgtcacgcag cagtgatgag ctggatgcgt ggacggactt ccgttcacgc     1860

accaattcta acgccagcac agtcagtggc cgcctgtcgc ccatcatggc aagcacagag     1920

ttggatgaag tccaggacga tgatgcgcct ctctcgccca tgctctacag cagctcagcc     1980

agcctgtcac cttcagtaag caagccgtgc acggtggaac tgccacggct gactgatatg     2040

gcaggcacca tgaatctgaa tgatgggctg actgaaaacc tcatggacga cctgctggat     2100

aacatcacgc tcccgccatc ccagccatcg cccactgggg gactcatgca gcggagctct     2160

agcttcccgt ataccaccaa gggctcgggc ctgggctccc caaccagctc ctttaacagc     2220

acggtgttcg gaccttcatc tctgaactcc ctacgccagt ctcccatgca gaccatccaa     2280

gagaacaagc cagctacctt ctcttccatg tcacactatg gtaaccagac actccaggac     2340

ctgctcactt cggactcact tagccacagc gatgtcatga tgacacagtc ggaccccttg     2400

atgtctcagg ccagcaccgc tgtgtctgcc cagaattccc gccggaacgt gatgcttcgc     2460

aatgatccga tgatgtcctt tgctgcccag cctaaccagg gaagtttggt caatcagaac     2520

ttgctccacc accagcacca aacccagggc gctcttggtg gcagccgtgc cttgtcgaat     2580

tctgtcagca acatgggctt gagtgagtcc agcagccttg ggtcagccaa acaccagcag     2640

cagtctcctg tcagccagtc tatgcaaacc ctctcggact ctctctcagg ctcctccttg     2700

tactcaacta gtgcaaacct gcccgtcatg ggccatgaga agttccccag cgacttggac     2760

ctggacatgt tcaatgggag cttggaatgt gacatggagt ccattatccg tagtgaactc     2820

atggatgctg atgggttgga ttttaacttt gattccctca tctccacaca gaatgttgtt     2880

ggtttgaacg tggggaactt cactggtgct aagcaggcct catctcagag ctgggtgcca     2940

ggctgaagga tcactgagga aggggaagtg ggcaaagcag accctcaaac tgacacaaga     3000

cctacagaga aaaccctttg ccaaatctgc tctcagcaag tggacagtga taccgtttac     3060

agcttaacac ctttgtgaat cccacgccat tttcctaacc cagcagagac tgttaatggc     3120

cccttaccct gggtgaagca cttacccttg gaacagaact ctaaaaagta tgcaaaatct     3180

tcc                                                                   3183


