                         SEQUENCE LISTING

<110>  UCL BUSINESS PLC
 
<120>  TREATMENTS

<130>  N403361WO

<150>  GB1412011.7
<151>  2014-07-04

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  3459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SID1


<220>
<221>  CDS
<222>  (1)..(3459)

<400>  1
atg agg gag ccg gaa gag ctg atg ccc gat tcg ggt gct gtg ttt aca         48
Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr           
1               5                   10                  15                

ttt ggg aaa agt aaa ttt gct gaa aat aat ccc ggt aaa ttc tgg ttt         96
Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe           
            20                  25                  30                    

aaa aat gat gtc cct gta cat ctt tca tgt gga gat gaa cat tct gct        144
Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala           
        35                  40                  45                        

gtt gtt acc gga aat aat aaa ctt tac atg ttt ggc agt aac aac tgg        192
Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp           
    50                  55                  60                            

ggt cag tta gga tta gga tca aag tca gcc atc agc aag cca aca tgt        240
Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys           
65                  70                  75                  80            

gtc aaa gct cta aaa cct gaa aaa gtg aaa tta gct gcc tgt gga agg        288
Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg           
                85                  90                  95                

aac cac acc ctg gtg tca aca gaa gga ggc aat gta tat gca act ggt        336
Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly           
            100                 105                 110                   

gga aat aat gaa gga cag ttg ggg ctt ggt gac acc gaa gaa aga aac        384
Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn           
        115                 120                 125                       

act ttt cat gta att agc ttt ttt aca tcc gag cat aag att aag cag        432
Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln           
    130                 135                 140                           

ctg tct gct gga tct aat act tca gct gcc cta act gag gat gga aga        480
Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg           
145                 150                 155                 160           

ctt ttt atg tgg ggt gac aat tcc gaa ggg caa att ggt tta aaa aat        528
Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn           
                165                 170                 175               

gta agt aat gtc tgt gtc cct cag caa gtg acc att ggg aaa cct gtc        576
Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val           
            180                 185                 190                   

tcc tgg atc tct tgt gga tat tac cat tca gct ttt gta aca aca gat        624
Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp           
        195                 200                 205                       

ggt gag cta tat gtg ttt gga gaa cct gag aat ggg aag tta ggt ctt        672
Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu           
    210                 215                 220                           

ccc aat cag ctc ctg ggc aat cac aga aca ccc cag ctg gtg tct gaa        720
Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu           
225                 230                 235                 240           

att ccg gag aag gtg atc caa gta gcc tgt ggt gga gag cat act gtg        768
Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val           
                245                 250                 255               

gtt ctc acg gag aat gct gtg tat acc ttt ggg ctg gga caa ttt ggt        816
Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly           
            260                 265                 270                   

cag ctg ggt ctt ggc act ttt ctt ttt gaa act tca gaa ccc aaa gtc        864
Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val           
        275                 280                 285                       

att gag aat att agg gat caa aca ata agt tat att tct tgt gga gaa        912
Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu           
    290                 295                 300                           

aat cac aca gct ttg ata aca gat atc ggc ctt atg tat act ttt gga        960
Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly           
305                 310                 315                 320           

gat ggt cgc cac gga aaa tta gga ctt gga ctg gag aat ttt acc aat       1008
Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn           
                325                 330                 335               

cac ttc att cct act ttg tgc tct aat ttt ttg agg ttt ata gtt aaa       1056
His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys           
            340                 345                 350                   

ttg gtt gct tgt ggt gga tgt cac atg gta gtt ttt gct gct cct cat       1104
Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His           
        355                 360                 365                       

cgt ggt gtg gca aaa gaa att gaa ttc gat gaa ata aat gat act tgc       1152
Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys           
    370                 375                 380                           

tta tct gtg gcg act ttt ctg ccg tat agc agt tta acc tca gga aat       1200
Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn           
385                 390                 395                 400           

gta ctg cag agg act cta tca gca cgt atg cgg cga aga gag agg gag       1248
Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu           
                405                 410                 415               

agg tct cca gat tct ttt tca atg agg aga aca cta cct cca ata gaa       1296
Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu           
            420                 425                 430                   

ggg act ctt ggc ctt tct gct tgt ttt ctc ccc aat tca gtc ttt cca       1344
Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro           
        435                 440                 445                       

cga tgt tct gag aga aac ctc caa gag agt gtc tta tct gaa cag gac       1392
Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp           
    450                 455                 460                           

ctc atg cag cca gag gaa cca gat tat ttg cta gat gaa atg acc aaa       1440
Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys           
465                 470                 475                 480           

gaa gca gag ata gat aat tct tca act gta gaa agc ctt gga gaa act       1488
Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr           
                485                 490                 495               

act gat atc tta aac atg aca cac atc atg agc ctg aat tcc aat gaa       1536
Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu           
            500                 505                 510                   

aag tca tta aaa tta tca cca gtt cag aaa caa aag aaa caa caa aca       1584
Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr           
        515                 520                 525                       

att ggg gaa ctg acg cag gat aca gct ctt act gaa aac gat gat agt       1632
Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser           
    530                 535                 540                           

gat gaa tat gaa gaa atg tca gaa atg aaa gaa ggg aaa gca tgt aaa       1680
Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys           
545                 550                 555                 560           

caa cat gtg tca caa ggg att ttc atg acg cag cca gct acg act atc       1728
Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile           
                565                 570                 575               

gaa gca ttt tca gat gag gaa gta gag atc cca gag gag aag gaa gga       1776
Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly           
            580                 585                 590                   

gca gag gat tca aaa gga aat gga ata gag gag caa gag gta gaa gca       1824
Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala           
        595                 600                 605                       

aat gag gaa aat gtg aag gtg cat gga gga aga aag gag aaa aca gag       1872
Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu           
    610                 615                 620                           

atc cta tca gat gac ctt aca gac aaa gca gag gtg agt gaa ggc aag       1920
Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys           
625                 630                 635                 640           

gca aaa tca gtg gga gaa gca gag gat ggg cct gaa ggt aga ggg gat       1968
Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp           
                645                 650                 655               

gga acc tgt gag gaa ggt agt tca gga gca gaa cac tgg caa gat gag       2016
Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu           
            660                 665                 670                   

gag agg gag aag ggg gag aaa gac aag ggt aga gga gaa atg gag agg       2064
Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg           
        675                 680                 685                       

cca gga gag gga gag aag gaa cta gca gag aag gaa gaa tgg aag aag       2112
Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys           
    690                 695                 700                           

agg gat ggg gaa gag cag gag caa aag gag agg gag cag ggc cat cag       2160
Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln           
705                 710                 715                 720           

aag gaa aga aac caa gag atg gag gag gga ggg gag gag gag cat gga       2208
Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly           
                725                 730                 735               

gaa gga gaa gaa gag gag gga gac aga gaa gag gaa gaa gag aag gag       2256
Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu           
            740                 745                 750                   

gga gaa ggg aaa gag gaa gga gaa ggg gaa gaa gtg gag gga gaa cgt       2304
Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg           
        755                 760                 765                       

gaa aag gag gaa gga gag agg aaa aag gag gaa aga gcg ggg aag gag       2352
Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu           
    770                 775                 780                           

gag aaa gga gag gaa gaa gga gac caa gga gag ggg gaa gag gag gaa       2400
Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu           
785                 790                 795                 800           

aca gag ggg aga ggg gag gaa aaa gag gag gga ggg gaa gta gag gga       2448
Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly           
                805                 810                 815               

ggg gaa gta gag gag ggg aaa gga gag agg gaa gag gaa gag gag gag       2496
Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Glu Glu Glu Glu           
            820                 825                 830                   

ggt gag ggg gaa gag gag gaa ggg gag ggg gaa gag gag gaa ggg gag       2544
Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu           
        835                 840                 845                       

ggg gaa gag gag gaa gga gaa ggg aaa ggg gag gaa gaa ggg gaa gaa       2592
Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu           
    850                 855                 860                           

gga gaa ggg gag gaa gaa ggg gag gaa gga gaa ggg gag ggg gaa gag       2640
Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu           
865                 870                 875                 880           

gag gaa gga gaa ggg gag gga gaa gag gaa gga gaa ggg gag gga gaa       2688
Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu           
                885                 890                 895               

gag gag gaa gga gaa ggg gag gga gaa gag gaa gga gaa ggg gag gga       2736
Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly           
            900                 905                 910                   

gaa gag gag gaa gga gaa ggg aaa ggg gag gag gaa gga gag gaa gga       2784
Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu Gly           
        915                 920                 925                       

gaa ggg gag ggg gaa gag gag gaa gga gaa ggg gaa ggg gag gat gga       2832
Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Asp Gly           
    930                 935                 940                           

gaa ggg gag ggg gaa gag gag gaa gga gaa tgg gag ggg gaa gag gag       2880
Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu Gly Glu Glu Glu           
945                 950                 955                 960           

gaa gga gaa ggg gag ggg gaa gag gaa gga gaa ggg gaa ggg gag gaa       2928
Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu           
                965                 970                 975               

gga gaa ggg gag ggg gaa gag gag gaa gga gaa ggg gag ggg gaa gag       2976
Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu           
            980                 985                 990                   

gag gaa ggg gaa gaa gaa ggg gag  gaa gaa gga gag gga  gag gaa gaa     3024
Glu Glu Gly Glu Glu Glu Gly Glu  Glu Glu Gly Glu Gly  Glu Glu Glu         
        995                 1000                 1005                     

ggg gag  gga gaa ggg gag gaa  gaa gag gaa ggg gaa  gtg gaa ggg        3069
Gly Glu  Gly Glu Gly Glu Glu  Glu Glu Glu Gly Glu  Val Glu Gly            
    1010                 1015                 1020                        

gag gtg  gaa ggg gag gaa gga  gag ggg gaa gga gag  gaa gag gaa        3114
Glu Val  Glu Gly Glu Glu Gly  Glu Gly Glu Gly Glu  Glu Glu Glu            
    1025                 1030                 1035                        

gga gag  gag gaa gga gaa gaa  agg gaa aag gag ggg  gaa gga gaa        3159
Gly Glu  Glu Glu Gly Glu Glu  Arg Glu Lys Glu Gly  Glu Gly Glu            
    1040                 1045                 1050                        

gaa aac  agg agg aac aga gaa  gag gag gag gaa gaa  gag ggg aag        3204
Glu Asn  Arg Arg Asn Arg Glu  Glu Glu Glu Glu Glu  Glu Gly Lys            
    1055                 1060                 1065                        

tat cag  gag aca ggc gaa gaa  gag aat gaa agg cag  gat gga gag        3249
Tyr Gln  Glu Thr Gly Glu Glu  Glu Asn Glu Arg Gln  Asp Gly Glu            
    1070                 1075                 1080                        

gag tac  aaa aaa gtg agc aaa  ata aaa gga tct gtg  aaa tat ggc        3294
Glu Tyr  Lys Lys Val Ser Lys  Ile Lys Gly Ser Val  Lys Tyr Gly            
    1085                 1090                 1095                        

aaa cat  aaa aca tat caa aaa  aag tca gtt act aac  aca cag gga        3339
Lys His  Lys Thr Tyr Gln Lys  Lys Ser Val Thr Asn  Thr Gln Gly            
    1100                 1105                 1110                        

aat ggg  aaa gag cag agg tcc  aaa atg cca gtc cag  tca aaa cga        3384
Asn Gly  Lys Glu Gln Arg Ser  Lys Met Pro Val Gln  Ser Lys Arg            
    1115                 1120                 1125                        

ctt tta  aaa aat ggg cca tca  ggt tcc aaa aag ttc  tgg aat aat        3429
Leu Leu  Lys Asn Gly Pro Ser  Gly Ser Lys Lys Phe  Trp Asn Asn            
    1130                 1135                 1140                        

ata tta  cca cat tac ttg gaa  ttg aag taa                             3459
Ile Leu  Pro His Tyr Leu Glu  Leu Lys                                     
    1145                 1150                                             


<210>  2
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys 
625                 630                 635                 640 


Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp 
                645                 650                 655     


Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu 
            660                 665                 670         


Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg 
        675                 680                 685             


Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys 
    690                 695                 700                 


Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln 
705                 710                 715                 720 


Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly 
                725                 730                 735     


Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu 
            740                 745                 750         


Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg 
        755                 760                 765             


Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu 
    770                 775                 780                 


Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu 
785                 790                 795                 800 


Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly 
                805                 810                 815     


Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu 
        835                 840                 845             


Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu 
    850                 855                 860                 


Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu 
865                 870                 875                 880 


Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu 
                885                 890                 895     


Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly 
            900                 905                 910         


Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu Gly 
        915                 920                 925             


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Asp Gly 
    930                 935                 940                 


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu Gly Glu Glu Glu 
945                 950                 955                 960 


Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
                965                 970                 975     


Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
            980                 985                 990         


Glu Glu Gly Glu Glu Glu Gly Glu  Glu Glu Gly Glu Gly  Glu Glu Glu 
        995                 1000                 1005             


Gly Glu  Gly Glu Gly Glu Glu  Glu Glu Glu Gly Glu  Val Glu Gly 
    1010                 1015                 1020             


Glu Val  Glu Gly Glu Glu Gly  Glu Gly Glu Gly Glu  Glu Glu Glu 
    1025                 1030                 1035             


Gly Glu  Glu Glu Gly Glu Glu  Arg Glu Lys Glu Gly  Glu Gly Glu 
    1040                 1045                 1050             


Glu Asn  Arg Arg Asn Arg Glu  Glu Glu Glu Glu Glu  Glu Gly Lys 
    1055                 1060                 1065             


Tyr Gln  Glu Thr Gly Glu Glu  Glu Asn Glu Arg Gln  Asp Gly Glu 
    1070                 1075                 1080             


Glu Tyr  Lys Lys Val Ser Lys  Ile Lys Gly Ser Val  Lys Tyr Gly 
    1085                 1090                 1095             


Lys His  Lys Thr Tyr Gln Lys  Lys Ser Val Thr Asn  Thr Gln Gly 
    1100                 1105                 1110             


Asn Gly  Lys Glu Gln Arg Ser  Lys Met Pro Val Gln  Ser Lys Arg 
    1115                 1120                 1125             


Leu Leu  Lys Asn Gly Pro Ser  Gly Ser Lys Lys Phe  Trp Asn Asn 
    1130                 1135                 1140             


Ile Leu  Pro His Tyr Leu Glu  Leu Lys 
    1145                 1150         


<210>  3
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SID2


<220>
<221>  CDS
<222>  (1)..(456)

<400>  3
gaa gag gag gag ggt gag ggg gaa gag gag gaa ggg gag ggg gaa gag         48
Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu           
1               5                   10                  15                

gag gaa ggg gag ggg gaa gag gag gaa gga gaa ggg aaa ggg gag gaa         96
Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu           
            20                  25                  30                    

gaa ggg gaa gaa gga gaa ggg gag gaa gaa ggg gag gaa gga gaa ggg        144
Glu Gly Glu Glu Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly           
        35                  40                  45                        

gag ggg gaa gag gag gaa gga gaa ggg gag gga gaa gag gaa gga gaa        192
Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu           
    50                  55                  60                            

ggg gag gga gaa gag gag gaa gga gaa ggg gag gga gaa gag gaa gga        240
Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly           
65                  70                  75                  80            

gaa ggg gag gga gaa gag gag gaa gga gaa ggg aaa ggg gag gag gaa        288
Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu           
                85                  90                  95                

gga gag gaa gga gaa ggg gag ggg gaa gag gag gaa gga gaa ggg gaa        336
Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu           
            100                 105                 110                   

ggg gag gat gga gaa ggg gag ggg gaa gag gag gaa gga gaa tgg gag        384
Gly Glu Asp Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu           
        115                 120                 125                       

ggg gaa gag gag gaa gga gaa ggg gag ggg gaa gag gaa gga gaa ggg        432
Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly           
    130                 135                 140                           

gaa ggg gag gaa gga gaa ggg gag                                        456
Glu Gly Glu Glu Gly Glu Gly Glu                                           
145                 150                                                   


<210>  4
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu 
1               5                   10                  15      


Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu 
            20                  25                  30          


Glu Gly Glu Glu Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly 
        35                  40                  45              


Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu 
    50                  55                  60                  


Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly 
65                  70                  75                  80  


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu 
                85                  90                  95      


Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu 
            100                 105                 110         


Gly Glu Asp Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly 
    130                 135                 140                 


Glu Gly Glu Glu Gly Glu Gly Glu 
145                 150         


<210>  5
<211>  3003
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SID3


<220>
<221>  CDS
<222>  (1)..(3003)

<400>  5
atg agg gag ccg gaa gag ctg atg ccc gat tcg ggt gct gtg ttt aca         48
Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr           
1               5                   10                  15                

ttt ggg aaa agt aaa ttt gct gaa aat aat ccc ggt aaa ttc tgg ttt         96
Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe           
            20                  25                  30                    

aaa aat gat gtc cct gta cat ctt tca tgt gga gat gaa cat tct gct        144
Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala           
        35                  40                  45                        

gtt gtt acc gga aat aat aaa ctt tac atg ttt ggc agt aac aac tgg        192
Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp           
    50                  55                  60                            

ggt cag tta gga tta gga tca aag tca gcc atc agc aag cca aca tgt        240
Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys           
65                  70                  75                  80            

gtc aaa gct cta aaa cct gaa aaa gtg aaa tta gct gcc tgt gga agg        288
Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg           
                85                  90                  95                

aac cac acc ctg gtg tca aca gaa gga ggc aat gta tat gca act ggt        336
Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly           
            100                 105                 110                   

gga aat aat gaa gga cag ttg ggg ctt ggt gac acc gaa gaa aga aac        384
Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn           
        115                 120                 125                       

act ttt cat gta att agc ttt ttt aca tcc gag cat aag att aag cag        432
Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln           
    130                 135                 140                           

ctg tct gct gga tct aat act tca gct gcc cta act gag gat gga aga        480
Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg           
145                 150                 155                 160           

ctt ttt atg tgg ggt gac aat tcc gaa ggg caa att ggt tta aaa aat        528
Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn           
                165                 170                 175               

gta agt aat gtc tgt gtc cct cag caa gtg acc att ggg aaa cct gtc        576
Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val           
            180                 185                 190                   

tcc tgg atc tct tgt gga tat tac cat tca gct ttt gta aca aca gat        624
Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp           
        195                 200                 205                       

ggt gag cta tat gtg ttt gga gaa cct gag aat ggg aag tta ggt ctt        672
Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu           
    210                 215                 220                           

ccc aat cag ctc ctg ggc aat cac aga aca ccc cag ctg gtg tct gaa        720
Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu           
225                 230                 235                 240           

att ccg gag aag gtg atc caa gta gcc tgt ggt gga gag cat act gtg        768
Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val           
                245                 250                 255               

gtt ctc acg gag aat gct gtg tat acc ttt ggg ctg gga caa ttt ggt        816
Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly           
            260                 265                 270                   

cag ctg ggt ctt ggc act ttt ctt ttt gaa act tca gaa ccc aaa gtc        864
Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val           
        275                 280                 285                       

att gag aat att agg gat caa aca ata agt tat att tct tgt gga gaa        912
Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu           
    290                 295                 300                           

aat cac aca gct ttg ata aca gat atc ggc ctt atg tat act ttt gga        960
Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly           
305                 310                 315                 320           

gat ggt cgc cac gga aaa tta gga ctt gga ctg gag aat ttt acc aat       1008
Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn           
                325                 330                 335               

cac ttc att cct act ttg tgc tct aat ttt ttg agg ttt ata gtt aaa       1056
His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys           
            340                 345                 350                   

ttg gtt gct tgt ggt gga tgt cac atg gta gtt ttt gct gct cct cat       1104
Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His           
        355                 360                 365                       

cgt ggt gtg gca aaa gaa att gaa ttc gat gaa ata aat gat act tgc       1152
Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys           
    370                 375                 380                           

tta tct gtg gcg act ttt ctg ccg tat agc agt tta acc tca gga aat       1200
Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn           
385                 390                 395                 400           

gta ctg cag agg act cta tca gca cgt atg cgg cga aga gag agg gag       1248
Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu           
                405                 410                 415               

agg tct cca gat tct ttt tca atg agg aga aca cta cct cca ata gaa       1296
Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu           
            420                 425                 430                   

ggg act ctt ggc ctt tct gct tgt ttt ctc ccc aat tca gtc ttt cca       1344
Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro           
        435                 440                 445                       

cga tgt tct gag aga aac ctc caa gag agt gtc tta tct gaa cag gac       1392
Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp           
    450                 455                 460                           

ctc atg cag cca gag gaa cca gat tat ttg cta gat gaa atg acc aaa       1440
Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys           
465                 470                 475                 480           

gaa gca gag ata gat aat tct tca act gta gaa agc ctt gga gaa act       1488
Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr           
                485                 490                 495               

act gat atc tta aac atg aca cac atc atg agc ctg aat tcc aat gaa       1536
Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu           
            500                 505                 510                   

aag tca tta aaa tta tca cca gtt cag aaa caa aag aaa caa caa aca       1584
Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr           
        515                 520                 525                       

att ggg gaa ctg acg cag gat aca gct ctt act gaa aac gat gat agt       1632
Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser           
    530                 535                 540                           

gat gaa tat gaa gaa atg tca gaa atg aaa gaa ggg aaa gca tgt aaa       1680
Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys           
545                 550                 555                 560           

caa cat gtg tca caa ggg att ttc atg acg cag cca gct acg act atc       1728
Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile           
                565                 570                 575               

gaa gca ttt tca gat gag gaa gta gag atc cca gag gag aag gaa gga       1776
Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly           
            580                 585                 590                   

gca gag gat tca aaa gga aat gga ata gag gag caa gag gta gaa gca       1824
Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala           
        595                 600                 605                       

aat gag gaa aat gtg aag gtg cat gga gga aga aag gag aaa aca gag       1872
Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu           
    610                 615                 620                           

atc cta tca gat gac ctt aca gac aaa gca gag gtg agt gaa ggc aag       1920
Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys           
625                 630                 635                 640           

gca aaa tca gtg gga gaa gca gag gat ggg cct gaa ggt aga ggg gat       1968
Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp           
                645                 650                 655               

gga acc tgt gag gaa ggt agt tca gga gca gaa cac tgg caa gat gag       2016
Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu           
            660                 665                 670                   

gag agg gag aag ggg gag aaa gac aag ggt aga gga gaa atg gag agg       2064
Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg           
        675                 680                 685                       

cca gga gag gga gag aag gaa cta gca gag aag gaa gaa tgg aag aag       2112
Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys           
    690                 695                 700                           

agg gat ggg gaa gag cag gag caa aag gag agg gag cag ggc cat cag       2160
Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln           
705                 710                 715                 720           

aag gaa aga aac caa gag atg gag gag gga ggg gag gag gag cat gga       2208
Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly           
                725                 730                 735               

gaa gga gaa gaa gag gag gga gac aga gaa gag gaa gaa gag aag gag       2256
Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu           
            740                 745                 750                   

gga gaa ggg aaa gag gaa gga gaa ggg gaa gaa gtg gag gga gaa cgt       2304
Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg           
        755                 760                 765                       

gaa aag gag gaa gga gag agg aaa aag gag gaa aga gcg ggg aag gag       2352
Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu           
    770                 775                 780                           

gag aaa gga gag gaa gaa gga gac caa gga gag ggg gaa gag gag gaa       2400
Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu           
785                 790                 795                 800           

aca gag ggg aga ggg gag gaa aaa gag gag gga ggg gaa gta gag gga       2448
Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly           
                805                 810                 815               

ggg gaa gta gag gag ggg aaa gga gag agg gaa gag ggg gaa gag gag       2496
Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Gly Glu Glu Glu           
            820                 825                 830                   

gaa gga gaa ggg gag ggg gaa gag gag gaa ggg gaa gaa gaa ggg gag       2544
Glu Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Glu Glu Gly Glu           
        835                 840                 845                       

gaa gaa gga gag gga gag gaa gaa ggg gag gga gaa ggg gag gaa gaa       2592
Glu Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu           
    850                 855                 860                           

gag gaa ggg gaa gtg gaa ggg gag gtg gaa ggg gag gaa gga gag ggg       2640
Glu Glu Gly Glu Val Glu Gly Glu Val Glu Gly Glu Glu Gly Glu Gly           
865                 870                 875                 880           

gaa gga gag gaa gag gaa gga gag gag gaa gga gaa gaa agg gaa aag       2688
Glu Gly Glu Glu Glu Glu Gly Glu Glu Glu Gly Glu Glu Arg Glu Lys           
                885                 890                 895               

gag ggg gaa gga gaa gaa aac agg agg aac aga gaa gag gag gag gaa       2736
Glu Gly Glu Gly Glu Glu Asn Arg Arg Asn Arg Glu Glu Glu Glu Glu           
            900                 905                 910                   

gaa gag ggg aag tat cag gag aca ggc gaa gaa gag aat gaa agg cag       2784
Glu Glu Gly Lys Tyr Gln Glu Thr Gly Glu Glu Glu Asn Glu Arg Gln           
        915                 920                 925                       

gat gga gag gag tac aaa aaa gtg agc aaa ata aaa gga tct gtg aaa       2832
Asp Gly Glu Glu Tyr Lys Lys Val Ser Lys Ile Lys Gly Ser Val Lys           
    930                 935                 940                           

tat ggc aaa cat aaa aca tat caa aaa aag tca gtt act aac aca cag       2880
Tyr Gly Lys His Lys Thr Tyr Gln Lys Lys Ser Val Thr Asn Thr Gln           
945                 950                 955                 960           

gga aat ggg aaa gag cag agg tcc aaa atg cca gtc cag tca aaa cga       2928
Gly Asn Gly Lys Glu Gln Arg Ser Lys Met Pro Val Gln Ser Lys Arg           
                965                 970                 975               

ctt tta aaa aat ggg cca tca ggt tcc aaa aag ttc tgg aat aat ata       2976
Leu Leu Lys Asn Gly Pro Ser Gly Ser Lys Lys Phe Trp Asn Asn Ile           
            980                 985                 990                   

tta cca cat tac ttg gaa ttg aag  taa                                  3003
Leu Pro His Tyr Leu Glu Leu Lys                                           
        995                 1000                                          


<210>  6
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys 
625                 630                 635                 640 


Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp 
                645                 650                 655     


Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu 
            660                 665                 670         


Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg 
        675                 680                 685             


Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys 
    690                 695                 700                 


Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln 
705                 710                 715                 720 


Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly 
                725                 730                 735     


Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu 
            740                 745                 750         


Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg 
        755                 760                 765             


Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu 
    770                 775                 780                 


Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu 
785                 790                 795                 800 


Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly 
                805                 810                 815     


Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Gly Glu Glu Glu 
            820                 825                 830         


Glu Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Glu Glu Gly Glu 
        835                 840                 845             


Glu Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu 
    850                 855                 860                 


Glu Glu Gly Glu Val Glu Gly Glu Val Glu Gly Glu Glu Gly Glu Gly 
865                 870                 875                 880 


Glu Gly Glu Glu Glu Glu Gly Glu Glu Glu Gly Glu Glu Arg Glu Lys 
                885                 890                 895     


Glu Gly Glu Gly Glu Glu Asn Arg Arg Asn Arg Glu Glu Glu Glu Glu 
            900                 905                 910         


Glu Glu Gly Lys Tyr Gln Glu Thr Gly Glu Glu Glu Asn Glu Arg Gln 
        915                 920                 925             


Asp Gly Glu Glu Tyr Lys Lys Val Ser Lys Ile Lys Gly Ser Val Lys 
    930                 935                 940                 


Tyr Gly Lys His Lys Thr Tyr Gln Lys Lys Ser Val Thr Asn Thr Gln 
945                 950                 955                 960 


Gly Asn Gly Lys Glu Gln Arg Ser Lys Met Pro Val Gln Ser Lys Arg 
                965                 970                 975     


Leu Leu Lys Asn Gly Pro Ser Gly Ser Lys Lys Phe Trp Asn Asn Ile 
            980                 985                 990         


Leu Pro His Tyr Leu Glu Leu Lys  
        995                 1000 


