               SEQUENCE LISTING

<110> Affiris AG

<120> Vaccines and monoclonal antibodies targeting truncated variants of osteopontin and uses thereof

<130> R67614

<150> EP 14175005.9
<151> 30.06.2014

<160> 58

<170> BiSSAP 1.3

<210> 1
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 1
Val Val Tyr Gly Leu Arg 
1               5       

<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 2
Ser Val Val Tyr Gly Leu Arg 
1               5           

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 3
Asp Ser Val Val Tyr Gly Leu Arg 
1               5               

<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 4
Arg Gly Asp Ser Val Val Tyr Gly Leu Arg 
1               5                   10  

<210> 5
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 5
Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg 
1               5                   10          

<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 6
Asp Ser Val Val Tyr Gly 
1               5       

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 7
Gly Asp Ser Val Val Tyr Gly 
1               5           

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 8
Arg Gly Asp Ser Val Val Tyr Gly 
1               5               

<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 9
Asp Gly Arg Gly Asp Ser Val Val Tyr Gly 
1               5                   10  

<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 10
Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly 
1               5                   10          

<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 11
Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg 
1               5                   10          

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 12
Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly 
1               5                   10          

<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 13
Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val 
1               5                   10          

<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 14
Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser 
1               5                   10          

<210> 15
<211> 314
<212> PRT
<213> Homo sapiens

<220> 
<223> Osteopontin (Opn)

<400> 15
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  
Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  
Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      
Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         
Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             
Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 
Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 
Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     
Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         
Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             
Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 
Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 
Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     
His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         
Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             
Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 
Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 

<210> 16
<211> 166
<212> PRT
<213> Homo sapiens

<220> 
<223> MmpOpn

<400> 16
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  
Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  
Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      
Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         
Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             
Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 
Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 
Asp Ser Val Val Tyr Gly 
                165     

<210> 17
<211> 168
<212> PRT
<213> Homo sapiens

<220> 
<223> ThrOpn

<400> 17
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  
Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  
Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      
Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         
Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             
Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 
Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 
Asp Ser Val Val Tyr Gly Leu Arg 
                165             

<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VH CDR1

<400> 18
Gly Phe Ser Leu Ser Thr Tyr Gly Leu Gly 
1               5                   10  

<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VH CDR2

<400> 19
Ile Tyr Trp Asp Asp Asn Lys 
1               5           

<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VH CDR3

<400> 20
Ala Arg Gly Thr Ser Pro Gly Val Ser Phe Pro Tyr 
1               5                   10          

<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VL CDR1

<400> 21
Glu Asn Ile Tyr Ser Tyr 
1               5       

<210> 22
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VL CDR2

<400> 22
Asn Ala Lys 
1               

<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VL CDR3

<400> 23
Gln His His Tyr Gly Thr Pro Leu Thr 
1               5                   

<210> 24
<211> 151
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VH

<400> 24
Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      
Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          
Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              
Ser Thr Tyr Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asn Lys Arg Tyr 
65                  70                  75                  80  
Lys Ser Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      
Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         
Thr Tyr Tyr Cys Ala Arg Gly Thr Ser Pro Gly Val Ser Phe Pro Tyr 
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro 
    130                 135                 140                 
Pro Ser Val Tyr Pro Leu Ala 
145                 150     

<210> 25
<211> 162
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 4-4-2 VL

<400> 25
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      
Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn 
        35                  40                  45              
Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  
Gln Phe Leu Val Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr 
            100                 105                 110         
Gly Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Lys 
        

<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VH CDR1

<400> 26
Gly Ile Thr Phe Asn Thr Asn Gly 
1               5               

<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VH CDR2

<400> 27
Val Arg Ser Lys Asp Tyr Asn Phe Ala Thr 
1               5                   10  

<210> 28
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VH CDR3

<400> 28
Val Arg Pro Asp Tyr Tyr Gly Ser Ser Phe Ala Tyr 
1               5                   10          

<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VL CDR1

<400> 29
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VL CDR2

<400> 30
Lys Val Ser 
1               

<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VL CDR3

<400> 31
Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   

<210> 32
<211> 153
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VH

<400> 32
Met Leu Leu Gly Leu Lys Trp Val Phe Phe Val Val Phe Tyr Gln Gly 
1               5                   10                  15      
Val His Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Lys Gly Ala Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Phe 
        35                  40                  45              
Asn Thr Asn Gly Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu 
    50                  55                  60                  
Glu Trp Val Ala Arg Val Arg Ser Lys Asp Tyr Asn Phe Ala Thr Tyr 
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      
Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr 
            100                 105                 110         
Ala Met Tyr Tyr Cys Val Arg Pro Asp Tyr Tyr Gly Ser Ser Phe Ala 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ala Ala Lys Thr Thr 
    130                 135                 140                 
Pro Pro Pro Val Tyr Pro Leu Ala Pro 
145                 150             

<210> 33
<211> 166
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 7-5-4 VL

<400> 33
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              
Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         
Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 
Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg 
                165     

<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VH CDR1

<400> 34
Gly Phe Ser Leu Ser Thr Ser Gly Leu Gly 
1               5                   10  

<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VH CDR2

<400> 35
Ile Ser Trp Asp Asp Ser Lys 
1               5           

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VH CDR3

<400> 36
Ala Arg Ser Gly Gly Gly Asp Ser Asp 
1               5                   

<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VL CDR1

<400> 37
Ser Ser Val Asn Ser 
1               5   

<210> 38
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VL CDR2

<400> 38
Asp Thr Ser 
1               

<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VL CDR3

<400> 39
Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
1               5                   

<210> 40
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VH

<400> 40
Met Asp Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      
Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Met Leu Lys 
            20                  25                  30          
Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              
Ser Thr Ser Gly Leu Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Leu Ala His Ile Ser Trp Asp Asp Ser Lys Tyr Tyr 
65                  70                  75                  80  
Asn Pro Ser Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg 
                85                  90                  95      
Asn Gln Val Phe Leu Lys Ile Thr Asn Val Gly Thr Ala Asp Ser Ala 
            100                 105                 110         
Thr Tyr Phe Cys Ala Arg Ser Gly Gly Gly Asp Ser Asp Trp Gly Gln 
        115                 120                 125             
Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 
Phe Pro Leu Ala Pro 
145                 

<210> 41
<211> 163
<212> PRT
<213> Artificial Sequence

<220> 
<223> mAb 21-5-4 VL

<400> 41
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      
Val Ile Met Ser Arg Gly Ala Asn Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Asn 
        35                  40                  45              
Ser Ser Val Asn Ser Ile His Trp Tyr Gln Gln Lys Ser Ser Thr Ser 
    50                  55                  60                  
Pro Lys Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  
Gly Arg Phe Ser Gly Ser Gly Ser Gly Asp Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Ser Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly 
            100                 105                 110         
Ser Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 
Tyr Pro Lys 
            

<210> 42
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 42
agcggctctt caatgatacc agttaaacag gctgattc                             38


<210> 43
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 43
agcggctctt ctcccattga cctcagaaga tgcact                               36


<210> 44
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 44
agcggctctt ctcccctatc cataaaccac actatcacc                            39


<210> 45
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 45
agcggctctt ctcccctacc tcagtccata aaccacac                             38


<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse-derived peptide epitope

<400> 46
Ser Leu Ala Tyr Gly Leu Arg 
1               5           

<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse-derived peptide epitope

<400> 47
Val Asp Val Pro Asn Gly Arg Gly Asp Ser Leu Ala Tyr Gly Leu Arg 
1               5                   10                  15      



<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 48
Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg 
1               5                   10                  15      
Ser 
    

<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 49
Cys Ser Val Val Tyr Gly Leu Arg 
1               5               

<210> 50
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptipe epitope

<400> 50
Tyr Gly Leu Arg 
1               

<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 51
Val Tyr Gly Leu Arg Ser Lys 
1               5           

<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 52
Tyr Asp Gly Arg Gly Asp Ser 
1               5           

<210> 53
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 53
Thr Tyr Asp Gly Ala Ala Ala Ser Val Val Tyr Gly 
1               5                   10          

<210> 54
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 54
Thr Ala Ala Ala Arg Gly Asp Ala Ala Ala Tyr Gly 
1               5                   10          

<210> 55
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 55
Gly Arg Gly Asp Ser Val Val Tyr Gly 
1               5                   

<210> 56
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 56
Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr 
1               5                   10          

<210> 57
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 57
Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val 
1               5                   10          

<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 58
Gly Asp Ser Val Val Tyr Gly Leu Arg 
1               5                   


