                         SEQUENCE LISTING

<110>  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120>  INHIBITION OF SEROTONIN EXPRESSION IN GUT ENTEROENDOCRINE CELLS 
       RESULTS IN CONVERSION TO INSULIN-POSITIVE CELLS

<130>  15003-267PC0

<140>  PCT/US15/38186
<141>  2015-06-26

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Foxo1 target sequence

<400>  1
gcaccgactt tatgagcaac c                                                 21


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXO1-antisense

<400>  2
ttgggtcagg cggttca                                                      17


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXO3a-sense

<400>  3
cccagcctaa ccagggaagt                                                   20


<210>  4
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXO3a- antisense

<400>  4
agcgccctgg gtttgg                                                       16


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXO4-sense

<400>  5
cctgcacagc aagttcatca a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXO4-antisense

<400>  6
ttcagcatcc accaagagct t                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for INSULIN

<400>  7
ccagctggta gagggagcag at                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for INSULIN

<400>  8
tacctagtgt gcggggaacg ag                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NEUROGENIN3

<400>  9
tacatctggg cgctgactca aa                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NEUROGENIN3

<400>  10
agcctgggag actggggagt ag                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for CHROMOGRANIN A

<400>  11
gctccctgtg aacagcccta tg                                                22


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for CHROMOGRANIN A

<400>  12
cgaggtcttg gagctccttc ag                                                22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for FOXO1

<400>  13
gatggtcaag agcgtgccct ac                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for FOXO1

<400>  14
tggattgagc atccaccaag aa                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for FOXO3

<400>  15
ttgcgtgccc tacttcaagg at                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for FOXO3

<400>  16
agagctcttg ccagttccct ca                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for FOXO4

<400>  17
tcaaggacaa gggtgacagc aa                                                22


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for FOXO4

<400>  18
agggttcagc atccaccaag ag                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for VILLIN

<400>  19
cagtacccac caagcacaca gg                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for VILLIN

<400>  20
atggatgtgg catcgaactt ca                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for LYSOZYME

<400>  21
tggctacagg ggaatcagcc ta                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for LYSOZYME

<400>  22
ttaactgctc ctggggtttt gc                                                22


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MUC2

<400>  23
gtggagtcca gcacgggcat                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MUC2

<400>  24
tcaccaccat gtggtcccgc                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for CDX2

<400>  25
atcgagtggt gtacacggac ca                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for CDX2

<400>  26
ctctcctttg ctctgcggtt ct                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PC1

<400>  27
ataatcacaa atgcggggtt gg                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PC1

<400>  28
atcatcatta gggccccagc tt                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PC2

<400>  29
ttgcataaag ggggagagga ca                                                22


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PC2

<400>  30
cttcctgctg caaagccatc tt                                                22


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GLUT2

<400>  31
tgggatgttt gtttgtgcca tc                                                22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GLUT2

<400>  32
caggacgtgg tccttgactg aa                                                22


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GCK

<400>  33
tgagtgcatc tccgacttcc tg                                                22


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GCK

<400>  34
cgtttgatag cgtctcgcag aa                                                22


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for KIR6.2

<400>  35
ttgatgccaa cagcccactc ta                                                22


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for KIR6.2

<400>  36
tcctcagcta caatgggcac aa                                                22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SUR1

<400>  37
agtggccaca cacattgctc at                                                22


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SUR1

<400>  38
gaaggagtgg atgctggtga ca                                                22


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PAX6

<400>  39
actctgcgct tggccaagaa ct                                                22


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PAX6

<400>  40
gggctgaggg gtccatcaaa gg                                                22


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PAX4

<400>  41
gggctgactg taccaagggt tg                                                22


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PAX4

<400>  42
gcagggcttg agacaggctt ta                                                22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NKX2.2

<400>  43
ttctacgaca gcagcgacaa cc                                                22


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NKX2.2

<400>  44
ttgtcattgt ccggtgactc gt                                                22


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NKX6.1

<400>  45
gcctattcgt tggggatgac ag                                                22


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NKX6.1

<400>  46
cgagttggga tccagaggct ta                                                22


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for ARX

<400>  47
gaaacgcaaa cagaggcgct ac                                                22


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for ARX

<400>  48
ggttctggaa ccagacctgg ac                                                22


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NEUROD1

<400>  49
aagagacgcg gccccaaaaa ga                                                22


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for NEUROD1

<400>  50
tcttggccaa gcgcagagtc tc                                                22


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MAFA

<400>  51
tccttgtaca ggtcccgctc tt                                                22


<210>  52
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MAFA

<400>  52
cagtgccaac tcgctcttag gc                                                22


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MAFB

<400>  53
gttgctcgcc atccagtaca ga                                                22


<210>  54
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MAFB

<400>  54
tggattgagc atccaccaag aa                                                22


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PDX1

<400>  55
ctgcctttcc catggatgaa gt                                                22


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PDX1

<400>  56
cggccgtgag atgtacttgt tg                                                22


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for ISLET1

<400>  57
agcagcagcc caatgacaaa ac                                                22


<210>  58
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for ISLET1

<400>  58
cagttgctga aaagcaggct ga                                                22


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for RFX6

<400>  59
atcagcagca ttcgttcact gc                                                22


<210>  60
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for RFX6

<400>  60
ggaagaagga attggggttt gc                                                22


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SLC30A-8

<400>  61
gagcgcctgc tgtatcctga tt                                                22


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SLC30A-8

<400>  62
atgcacaaaa gcagctctga cg                                                22


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for UROCORTIN3

<400>  63
aggcctcccc cacaagttct ac                                                22


<210>  64
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for UROCORTIN3

<400>  64
ttctctttgc cctcctcctc ct                                                22


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for LGR5

<400>  65
ttcctcaaac cgtctgcaat ca                                                22


<210>  66
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for LGR5

<400>  66
ggaggctaag caactgctgg aa                                                22


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for OLFM4

<400>  67
tggctctgaa gaccaagctg aa                                                22


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for OLFM4

<400>  68
gtaatcccta ccccaagcac ca                                                22


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for BMI1

<400>  69
tgctgccaat ggctctaatg aa                                                22


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for BMI1

<400>  70
ttgctgctgg gcatcgtaag ta                                                22


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MATH1

<400>  71
aatggggtgc agaagcagag ac                                                22


<210>  72
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for MATH1

<400>  72
tcggacaagg cgttgatgta ga                                                22


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SUBSTANCE P

<400>  73
tacgacagcg accagatcaa gg                                                22


<210>  74
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SUBSTANCE P

<400>  74
gagcctttaa cagggccact tg                                                22


<210>  75
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GHRL

<400>  75
aaaggagtcg aagaagccac ca                                                22


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GHRL

<400>  76
tgctggtact gaacccctga ca                                                22


<210>  77
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PPY

<400>  77
ccacctgcgt ggctctgtta ct                                                22


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for PPY

<400>  78
ccagcgtgtc ctctttgtgt ct                                                22


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GLUCAGON

<400>  79
aggcagaccc actcagtgat cc                                                22


<210>  80
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GLUCAGON

<400>  80
catcgtgacg tttggcaatg tt                                                22


<210>  81
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for 5HT

<400>  81
caccacccta gtggctgagc tt                                                22


<210>  82
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for 5HT

<400>  82
ccatgatggt gtaggggagg ag                                                22


<210>  83
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SECRETIN

<400>  83
agcaggacgc agagaacagc at                                                22


<210>  84
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SECRETIN

<400>  84
gccagctggt tctgaaacca ta                                                22


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for CCK

<400>  85
agggtatcgc agagaacgga tg                                                22


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for CCK

<400>  86
gtcccggtca cttatcctgt gg                                                22


<210>  87
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GASTRIN

<400>  87
acccttaggt acaggggcca ac                                                22


<210>  88
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GASTRIN

<400>  88
gccgaagtcc atccatccat ag                                                22


<210>  89
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GIP

<400>  89
gcccaaaagg ggaagaagaa tg                                                22


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for GIP

<400>  90
gccaacagct cttgaatcag ca                                                22


<210>  91
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SOMATOSTATIN

<400>  91
gaccccagac tccgtcagtt tc                                                22


<210>  92
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for SOMATOSTATIN

<400>  92
ctgcagctca agcctcattt ca                                                22


<210>  93
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HES1

<400>  93
caacacgaca ccggataaac ca                                                22


<210>  94
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HES1

<400>  94
catttccaga atgtccgcct tc                                                22


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HESR1

<400>  95
ccgacgagac cggatcaata ac                                                22


<210>  96
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HESR1

<400>  96
ctgccgtatg cagcattttc ag                                                22


<210>  97
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HEYL

<400>  97
aagctggaga aagccgaggt ct                                                22


<210>  98
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HEYL

<400>  98
aaaccaatgc tccggaagtc aa                                                22


<210>  99
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for AES

<400>  99
gcctcaagct cgaatgtgac aa                                                22


<210>  100
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for AES

<400>  100
tggtgctctt gggagaggta gg                                                22


<210>  101
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HPRT

<400>  101
aatgaccagt caacagggga ca                                                22


<210>  102
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer sequence for HPRT

<400>  102
cacttcgtgg ggtccttttc ac                                                22


<210>  103
<211>  444
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TPH1 protein sequence

<400>  103

Met Ile Glu Asp Asn Lys Glu Asn Lys Asp His Ser Leu Glu Arg Gly 
1               5                   10                  15      


Arg Ala Ser Leu Ile Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Ile 
            20                  25                  30          


Lys Ala Leu Lys Ile Phe Gln Glu Lys His Val Asn Leu Leu His Ile 
        35                  40                  45              


Glu Ser Arg Lys Ser Lys Arg Arg Asn Ser Glu Phe Glu Ile Phe Val 
    50                  55                  60                  


Asp Cys Asp Ile Asn Arg Glu Gln Leu Asn Asp Ile Phe His Leu Leu 
65                  70                  75                  80  


Lys Ser His Thr Asn Val Leu Ser Val Asn Leu Pro Asp Asn Phe Thr 
                85                  90                  95      


Leu Lys Glu Asp Gly Met Glu Thr Val Pro Trp Phe Pro Lys Lys Ile 
            100                 105                 110         


Ser Asp Leu Asp His Cys Ala Asn Arg Val Leu Met Tyr Gly Ser Glu 
        115                 120                 125             


Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Lys Arg 
    130                 135                 140                 


Arg Lys Tyr Phe Ala Asp Leu Ala Met Asn Tyr Lys His Gly Asp Pro 
145                 150                 155                 160 


Ile Pro Lys Val Glu Phe Thr Glu Glu Glu Ile Lys Thr Trp Gly Thr 
                165                 170                 175     


Val Phe Gln Glu Leu Asn Lys Leu Tyr Pro Thr His Ala Cys Arg Glu 
            180                 185                 190         


Tyr Leu Lys Asn Leu Pro Leu Leu Ser Lys Tyr Cys Gly Tyr Arg Glu 
        195                 200                 205             


Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Asn Phe Leu Lys Glu Arg 
    210                 215                 220                 


Thr Gly Phe Ser Ile Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp 
225                 230                 235                 240 


Phe Leu Ser Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Val 
                245                 250                 255     


Arg His Ser Ser Asp Pro Phe Tyr Thr Pro Glu Pro Asp Thr Cys His 
            260                 265                 270         


Glu Leu Leu Gly His Val Pro Leu Leu Ala Glu Pro Ser Phe Ala Gln 
        275                 280                 285             


Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Glu Glu Ala 
    290                 295                 300                 


Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Val Glu Phe Gly Leu 
305                 310                 315                 320 


Cys Lys Gln Asp Gly Gln Leu Arg Val Phe Gly Ala Gly Leu Leu Ser 
                325                 330                 335     


Ser Ile Ser Glu Leu Lys His Ala Leu Ser Gly His Ala Lys Val Lys 
            340                 345                 350         


Pro Phe Asp Pro Lys Ile Thr Cys Lys Gln Glu Cys Leu Ile Thr Thr 
        355                 360                 365             


Phe Gln Asp Val Tyr Phe Val Ser Glu Ser Phe Glu Asp Ala Lys Glu 
    370                 375                 380                 


Lys Met Arg Glu Phe Thr Lys Thr Ile Lys Arg Pro Phe Gly Val Lys 
385                 390                 395                 400 


Tyr Asn Pro Tyr Thr Arg Ser Ile Gln Ile Leu Lys Asp Thr Lys Ser 
                405                 410                 415     


Ile Thr Ser Ala Met Asn Glu Leu Gln His Asp Leu Asp Val Val Ser 
            420                 425                 430         


Asp Ala Leu Ala Lys Val Ser Arg Lys Pro Ser Ile 
        435                 440                 


<210>  104
<211>  480
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  L-aromatic amino acid decarboxylase protein sequence

<400>  104

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  105
<211>  490
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  TPH2 protein sequence

<400>  105

Met Gln Pro Ala Met Met Met Phe Ser Ser Lys Tyr Trp Ala Arg Arg 
1               5                   10                  15      


Gly Phe Ser Leu Asp Ser Ala Val Pro Glu Glu His Gln Leu Leu Gly 
            20                  25                  30          


Ser Ser Thr Leu Asn Lys Pro Asn Ser Gly Lys Asn Asp Asp Lys Gly 
        35                  40                  45              


Asn Lys Gly Ser Ser Lys Arg Glu Ala Ala Thr Glu Ser Gly Lys Thr 
    50                  55                  60                  


Ala Val Val Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Val Lys Ala 
65                  70                  75                  80  


Leu Arg Leu Phe Gln Glu Lys Arg Val Asn Met Val His Ile Glu Ser 
                85                  90                  95      


Arg Lys Ser Arg Arg Arg Ser Ser Glu Val Glu Ile Phe Val Asp Cys 
            100                 105                 110         


Glu Cys Gly Lys Thr Glu Phe Asn Glu Leu Ile Gln Leu Leu Lys Phe 
        115                 120                 125             


Gln Thr Thr Ile Val Thr Leu Asn Pro Pro Glu Asn Ile Trp Thr Glu 
    130                 135                 140                 


Glu Glu Glu Leu Glu Asp Val Pro Trp Phe Pro Arg Lys Ile Ser Glu 
145                 150                 155                 160 


Leu Asp Lys Cys Ser His Arg Val Leu Met Tyr Gly Ser Glu Leu Asp 
                165                 170                 175     


Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Gln Arg Arg Lys 
            180                 185                 190         


Tyr Phe Val Asp Val Ala Met Gly Tyr Lys Tyr Gly Gln Pro Ile Pro 
        195                 200                 205             


Arg Val Glu Tyr Thr Glu Glu Glu Thr Lys Thr Trp Gly Val Val Phe 
    210                 215                 220                 


Arg Glu Leu Ser Lys Leu Tyr Pro Thr His Ala Cys Arg Glu Tyr Leu 
225                 230                 235                 240 


Lys Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg Glu Asp Asn 
                245                 250                 255     


Val Pro Gln Leu Glu Asp Val Ser Met Phe Leu Lys Glu Arg Ser Gly 
            260                 265                 270         


Phe Thr Val Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp Phe Leu 
        275                 280                 285             


Ala Gly Leu Ala Tyr Arg Val Phe His Cys Thr Gln Tyr Ile Arg His 
    290                 295                 300                 


Gly Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His Glu Leu 
305                 310                 315                 320 


Leu Gly His Val Pro Leu Leu Ala Asp Pro Lys Phe Ala Gln Phe Ser 
                325                 330                 335     


Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Asp Val Gln 
            340                 345                 350         


Lys Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu Phe Gly Leu Cys Lys 
        355                 360                 365             


Gln Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly Leu Leu Ser Ser Ile 
    370                 375                 380                 


Gly Glu Leu Lys His Ala Leu Ser Asp Lys Ala Cys Val Lys Ala Phe 
385                 390                 395                 400 


Asp Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu Ile Thr Thr Phe Gln 
                405                 410                 415     


Glu Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu Ala Lys Glu Lys Met 
            420                 425                 430         


Arg Asp Phe Ala Lys Ser Ile Thr Arg Pro Phe Ser Val Tyr Phe Asn 
        435                 440                 445             


Pro Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp Thr Arg Ser Ile Glu 
    450                 455                 460                 


Asn Val Val Gln Asp Leu Arg Ser Asp Leu Asn Thr Val Cys Asp Ala 
465                 470                 475                 480 


Leu Asn Lys Met Asn Gln Tyr Leu Gly Ile 
                485                 490 


