                         SEQUENCE LISTING

<110>  Muschler, John
       Korkola, James
 
<120>  COMPOUNDS THAT BIND DYSTROGLYCAN AND USES THEREOF

<130>  1993-2; 1993-3

<150>  62/018,440
<151>  2014-06-27

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Asp Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Pro Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Val Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  2
<211>  3075
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Gly Gly Val Leu Leu Val Leu Leu Leu Cys Val Ala Ala Gln 
1               5                   10                  15      


Cys Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn 
            20                  25                  30          


Ala His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met 
        35                  40                  45              


Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro 
    50                  55                  60                  


Gln Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His 
65                  70                  75                  80  


Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro 
                85                  90                  95      


Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp 
            100                 105                 110         


Leu Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn 
        115                 120                 125             


Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr 
    130                 135                 140                 


Thr Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu 
145                 150                 155                 160 


Ser Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala 
                165                 170                 175     


Asp Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu 
            180                 185                 190         


Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala 
        195                 200                 205             


Asp Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile 
    210                 215                 220                 


Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr 
225                 230                 235                 240 


Leu Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg 
                245                 250                 255     


Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys 
            260                 265                 270         


Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr Thr Lys Lys Leu 
        275                 280                 285             


Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asn Arg Cys 
    290                 295                 300                 


Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Val Ser Ser 
305                 310                 315                 320 


Gly Asn Thr Cys Glu Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys 
                325                 330                 335     


Tyr Tyr Asp Glu Ser Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala 
            340                 345                 350         


Gly Gln Phe Arg Gly Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr 
        355                 360                 365             


Met Gly Ile Asn Cys Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His 
    370                 375                 380                 


Lys Val Ser Pro Tyr Glu Asp Glu Pro Cys Arg Pro Cys Asn Cys Asp 
385                 390                 395                 400 


Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Leu His Ser 
                405                 410                 415     


Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys Pro Cys Lys Glu Gly 
            420                 425                 430         


Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu Gly Tyr Lys Asp Tyr 
        435                 440                 445             


Pro Thr Cys Val Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp 
    450                 455                 460                 


Glu Pro Cys Thr Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys 
465                 470                 475                 480 


Ala Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn 
                485                 490                 495     


Pro Arg Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Asp Val Cys 
            500                 505                 510         


Ser Ser Leu Ser Trp Pro Val Gly Gln Val Asn Ser Met Ser Gly Trp 
        515                 520                 525             


Leu Val Thr Asp Leu Ile Ser Pro Arg Lys Ile Pro Ser Gln Gln Asp 
    530                 535                 540                 


Ala Leu Gly Gly Arg His Gln Val Ser Ile Asn Asn Thr Ala Val Met 
545                 550                 555                 560 


Gln Arg Leu Ala Pro Lys Tyr Tyr Trp Ala Ala Pro Glu Ala Tyr Leu 
                565                 570                 575     


Gly Asn Lys Leu Thr Ala Phe Gly Gly Phe Leu Lys Tyr Thr Val Ser 
            580                 585                 590         


Tyr Asp Ile Pro Val Glu Thr Val Asp Ser Asn Leu Met Ser His Ala 
        595                 600                 605             


Asp Val Ile Ile Lys Gly Asn Gly Leu Thr Leu Ser Thr Gln Ala Glu 
    610                 615                 620                 


Gly Leu Ser Leu Gln Pro Tyr Glu Glu Tyr Leu Asn Val Val Arg Leu 
625                 630                 635                 640 


Val Pro Glu Asn Phe Gln Asp Phe His Ser Lys Arg Gln Ile Asp Arg 
                645                 650                 655     


Asp Gln Leu Met Thr Val Leu Ala Asn Val Thr His Leu Leu Ile Arg 
            660                 665                 670         


Ala Asn Tyr Asn Ser Ala Lys Met Ala Leu Tyr Arg Leu Glu Ser Val 
        675                 680                 685             


Ser Leu Asp Ile Ala Ser Ser Asn Ala Ile Asp Leu Val Val Ala Ala 
    690                 695                 700                 


Asp Val Glu His Cys Glu Cys Pro Gln Gly Tyr Thr Gly Thr Ser Cys 
705                 710                 715                 720 


Glu Ser Cys Leu Ser Gly Tyr Tyr Arg Val Asp Gly Ile Leu Phe Gly 
                725                 730                 735     


Gly Ile Cys Gln Pro Cys Glu Cys His Gly His Ala Ala Glu Cys Asn 
            740                 745                 750         


Val His Gly Val Cys Ile Ala Cys Ala His Asn Thr Thr Gly Val His 
        755                 760                 765             


Cys Glu Gln Cys Leu Pro Gly Phe Tyr Gly Glu Pro Ser Arg Gly Thr 
    770                 775                 780                 


Pro Gly Asp Cys Gln Pro Cys Ala Cys Pro Leu Thr Ile Ala Ser Asn 
785                 790                 795                 800 


Asn Phe Ser Pro Thr Cys His Leu Asn Asp Gly Asp Glu Val Val Cys 
                805                 810                 815     


Asp Trp Cys Ala Pro Gly Tyr Ser Gly Ala Trp Cys Glu Arg Cys Ala 
            820                 825                 830         


Asp Gly Tyr Tyr Gly Asn Pro Thr Val Pro Gly Glu Ser Cys Val Pro 
        835                 840                 845             


Cys Asp Cys Ser Gly Asn Val Asp Pro Ser Glu Ala Gly His Cys Asp 
    850                 855                 860                 


Ser Val Thr Gly Glu Cys Leu Lys Cys Leu Gly Asn Thr Asp Gly Ala 
865                 870                 875                 880 


His Cys Glu Arg Cys Ala Asp Gly Phe Tyr Gly Asp Ala Val Thr Ala 
                885                 890                 895     


Lys Asn Cys Arg Ala Cys Glu Cys His Val Lys Gly Ser His Ser Ala 
            900                 905                 910         


Val Cys His Leu Glu Thr Gly Leu Cys Asp Cys Lys Pro Asn Val Thr 
        915                 920                 925             


Gly Gln Gln Cys Asp Gln Cys Leu His Gly Tyr Tyr Gly Leu Asp Ser 
    930                 935                 940                 


Gly His Gly Cys Arg Pro Cys Asn Cys Ser Val Ala Gly Ser Val Ser 
945                 950                 955                 960 


Asp Gly Cys Thr Asp Glu Gly Gln Cys His Cys Val Pro Gly Val Ala 
                965                 970                 975     


Gly Lys Arg Cys Asp Arg Cys Ala His Gly Phe Tyr Ala Tyr Gln Asp 
            980                 985                 990         


Gly Ser Cys Thr Pro Cys Asp Cys  Pro His Thr Gln Asn  Thr Cys Asp 
        995                 1000                 1005             


Pro Glu  Thr Gly Glu Cys Val  Cys Pro Pro His Thr  Gln Gly Val 
    1010                 1015                 1020             


Lys Cys  Glu Glu Cys Glu Asp  Gly His Trp Gly Tyr  Asp Ala Glu 
    1025                 1030                 1035             


Val Gly  Cys Gln Ala Cys Asn  Cys Ser Leu Val Gly  Ser Thr His 
    1040                 1045                 1050             


His Arg  Cys Asp Val Val Thr  Gly His Cys Gln Cys  Lys Ser Lys 
    1055                 1060                 1065             


Phe Gly  Gly Arg Ala Cys Asp  Gln Cys Ser Leu Gly  Tyr Arg Asp 
    1070                 1075                 1080             


Phe Pro  Asp Cys Val Pro Cys  Asp Cys Asp Leu Arg  Gly Thr Ser 
    1085                 1090                 1095             


Gly Asp  Ala Cys Asn Leu Glu  Gln Gly Leu Cys Gly  Cys Val Glu 
    1100                 1105                 1110             


Glu Thr  Gly Ala Cys Pro Cys  Lys Glu Asn Val Phe  Gly Pro Gln 
    1115                 1120                 1125             


Cys Asn  Glu Cys Arg Glu Gly  Thr Phe Ala Leu Arg  Ala Asp Asn 
    1130                 1135                 1140             


Pro Leu  Gly Cys Ser Pro Cys  Phe Cys Ser Gly Leu  Ser His Leu 
    1145                 1150                 1155             


Cys Ser  Glu Leu Glu Asp Tyr  Val Arg Thr Pro Val  Thr Leu Gly 
    1160                 1165                 1170             


Ser Asp  Gln Pro Leu Leu Arg  Val Val Ser Gln Ser  Asn Leu Arg 
    1175                 1180                 1185             


Gly Thr  Thr Glu Gly Val Tyr  Tyr Gln Ala Pro Asp  Phe Leu Leu 
    1190                 1195                 1200             


Asp Ala  Ala Thr Val Arg Gln  His Ile Arg Ala Glu  Pro Phe Tyr 
    1205                 1210                 1215             


Trp Arg  Leu Pro Gln Gln Phe  Gln Gly Asp Gln Leu  Met Ala Tyr 
    1220                 1225                 1230             


Gly Gly  Lys Leu Lys Tyr Ser  Val Ala Phe Tyr Ser  Leu Asp Gly 
    1235                 1240                 1245             


Val Gly  Thr Ser Asn Phe Glu  Pro Gln Val Leu Ile  Lys Gly Gly 
    1250                 1255                 1260             


Arg Ile  Arg Lys Gln Val Ile  Tyr Met Asp Ala Pro  Ala Pro Glu 
    1265                 1270                 1275             


Asn Gly  Val Arg Gln Glu Gln  Glu Val Ala Met Arg  Glu Asn Phe 
    1280                 1285                 1290             


Trp Lys  Tyr Phe Asn Ser Val  Ser Glu Lys Pro Val  Thr Arg Glu 
    1295                 1300                 1305             


Asp Phe  Met Ser Val Leu Ser  Asp Ile Glu Tyr Ile  Leu Ile Lys 
    1310                 1315                 1320             


Ala Ser  Tyr Gly Gln Gly Leu  Gln Gln Ser Arg Ile  Ser Asp Ile 
    1325                 1330                 1335             


Ser Met  Glu Val Gly Arg Lys  Ala Glu Lys Leu His  Pro Glu Glu 
    1340                 1345                 1350             


Glu Val  Ala Ser Leu Leu Glu  Asn Cys Val Cys Pro  Pro Gly Thr 
    1355                 1360                 1365             


Val Gly  Phe Ser Cys Gln Asp  Cys Ala Pro Gly Tyr  His Arg Gly 
    1370                 1375                 1380             


Lys Leu  Pro Ala Gly Ser Asp  Arg Gly Pro Arg Pro  Leu Val Ala 
    1385                 1390                 1395             


Pro Cys  Val Pro Cys Ser Cys  Asn Asn His Ser Asp  Thr Cys Asp 
    1400                 1405                 1410             


Pro Asn  Thr Gly Lys Cys Leu  Asn Cys Gly Asp Asn  Thr Ala Gly 
    1415                 1420                 1425             


Asp His  Cys Asp Val Cys Thr  Ser Gly Tyr Tyr Gly  Lys Val Thr 
    1430                 1435                 1440             


Gly Ser  Ala Ser Asp Cys Ala  Leu Cys Ala Cys Pro  His Ser Pro 
    1445                 1450                 1455             


Pro Ala  Ser Phe Ser Pro Thr  Cys Val Leu Glu Gly  Asp His Asp 
    1460                 1465                 1470             


Phe Arg  Cys Asp Ala Cys Leu  Leu Gly Tyr Glu Gly  Lys His Cys 
    1475                 1480                 1485             


Glu Arg  Cys Ser Ser Ser Tyr  Tyr Gly Asn Pro Gln  Thr Pro Gly 
    1490                 1495                 1500             


Gly Ser  Cys Gln Lys Cys Asp  Cys Asn Pro His Gly  Ser Val His 
    1505                 1510                 1515             


Gly Asp  Cys Asp Arg Thr Ser  Gly Gln Cys Val Cys  Arg Leu Gly 
    1520                 1525                 1530             


Ala Ser  Gly Leu Arg Cys Asp  Glu Cys Glu Pro Arg  His Ile Leu 
    1535                 1540                 1545             


Met Glu  Thr Asp Cys Val Ser  Cys Asp Asp Glu Cys  Val Gly Val 
    1550                 1555                 1560             


Leu Leu  Asn Asp Leu Asp Glu  Ile Gly Asp Ala Val  Leu Ser Leu 
    1565                 1570                 1575             


Asn Leu  Thr Gly Ile Ile Pro  Val Pro Tyr Gly Ile  Leu Ser Asn 
    1580                 1585                 1590             


Leu Glu  Asn Thr Thr Lys Tyr  Leu Gln Glu Ser Leu  Leu Lys Glu 
    1595                 1600                 1605             


Asn Met  Gln Lys Asp Leu Gly  Lys Ile Lys Leu Glu  Gly Val Ala 
    1610                 1615                 1620             


Glu Glu  Thr Asp Asn Leu Gln  Lys Lys Leu Thr Arg  Met Leu Ala 
    1625                 1630                 1635             


Ser Thr  Gln Lys Val Asn Arg  Ala Thr Glu Arg Ile  Phe Lys Glu 
    1640                 1645                 1650             


Ser Gln  Asp Leu Ala Ile Ala  Ile Glu Arg Leu Gln  Met Ser Ile 
    1655                 1660                 1665             


Thr Glu  Ile Met Glu Lys Thr  Thr Leu Asn Gln Thr  Leu Asp Glu 
    1670                 1675                 1680             


Asp Phe  Leu Leu Pro Asn Ser  Thr Leu Gln Asn Met  Gln Gln Asn 
    1685                 1690                 1695             


Gly Thr  Ser Leu Leu Glu Ile  Met Gln Ile Arg Asp  Phe Thr Gln 
    1700                 1705                 1710             


Leu His  Gln Asn Ala Thr Leu  Glu Leu Lys Ala Ala  Glu Asp Leu 
    1715                 1720                 1725             


Leu Ser  Gln Ile Gln Glu Asn  Tyr Gln Lys Pro Leu  Glu Glu Leu 
    1730                 1735                 1740             


Glu Val  Leu Lys Glu Ala Ala  Ser His Val Leu Ser  Lys His Asn 
    1745                 1750                 1755             


Asn Glu  Leu Lys Ala Ala Glu  Ala Leu Val Arg Glu  Ala Glu Ala 
    1760                 1765                 1770             


Lys Met  Gln Glu Ser Asn His  Leu Leu Leu Met Val  Asn Ala Asn 
    1775                 1780                 1785             


Leu Arg  Glu Phe Ser Asp Lys  Lys Leu His Val Gln  Glu Glu Gln 
    1790                 1795                 1800             


Asn Leu  Thr Ser Glu Leu Ile  Val Gln Gly Arg Gly  Leu Ile Asp 
    1805                 1810                 1815             


Ala Ala  Ala Ala Gln Thr Asp  Ala Val Gln Asp Ala  Leu Glu His 
    1820                 1825                 1830             


Leu Glu  Asp His Gln Asp Lys  Leu Leu Leu Trp Ser  Ala Lys Ile 
    1835                 1840                 1845             


Arg His  His Ile Asp Asp Leu  Val Met His Met Ser  Gln Arg Asn 
    1850                 1855                 1860             


Ala Val  Asp Leu Val Tyr Arg  Ala Glu Asp His Ala  Ala Glu Phe 
    1865                 1870                 1875             


Gln Arg  Leu Ala Asp Val Leu  Tyr Ser Gly Leu Glu  Asn Ile Arg 
    1880                 1885                 1890             


Asn Val  Ser Leu Asn Ala Thr  Ser Ala Ala Tyr Val  His Tyr Asn 
    1895                 1900                 1905             


Ile Gln  Ser Leu Ile Glu Glu  Ser Glu Glu Leu Ala  Arg Asp Ala 
    1910                 1915                 1920             


His Arg  Thr Val Thr Glu Thr  Ser Leu Leu Ser Glu  Ser Leu Val 
    1925                 1930                 1935             


Ser Asn  Gly Lys Ala Ala Val  Gln Arg Ser Ser Arg  Phe Leu Lys 
    1940                 1945                 1950             


Glu Gly  Asn Asn Leu Ser Arg  Lys Leu Pro Gly Ile  Ala Leu Glu 
    1955                 1960                 1965             


Leu Ser  Glu Leu Arg Asn Lys  Thr Asn Arg Phe Gln  Glu Asn Ala 
    1970                 1975                 1980             


Val Glu  Ile Thr Arg Gln Thr  Asn Glu Ser Leu Leu  Ile Leu Arg 
    1985                 1990                 1995             


Ala Ile  Pro Lys Gly Ile Arg  Asp Lys Gly Ala Lys  Thr Lys Glu 
    2000                 2005                 2010             


Leu Ala  Thr Ser Ala Ser Gln  Ser Ala Val Ser Thr  Leu Arg Asp 
    2015                 2020                 2025             


Val Ala  Gly Leu Ser Gln Glu  Leu Leu Asn Thr Ser  Ala Ser Leu 
    2030                 2035                 2040             


Ser Arg  Val Asn Thr Thr Leu  Arg Glu Thr His Gln  Leu Leu Gln 
    2045                 2050                 2055             


Asp Ser  Thr Met Ala Thr Leu  Leu Ala Gly Arg Lys  Val Lys Asp 
    2060                 2065                 2070             


Val Glu  Ile Gln Ala Asn Leu  Leu Phe Asp Arg Leu  Lys Pro Leu 
    2075                 2080                 2085             


Lys Met  Leu Glu Glu Asn Leu  Ser Arg Asn Leu Ser  Glu Ile Lys 
    2090                 2095                 2100             


Leu Leu  Ile Ser Gln Ala Arg  Lys Gln Ala Ala Ser  Ile Lys Val 
    2105                 2110                 2115             


Ala Val  Ser Ala Asp Arg Asp  Cys Ile Arg Ala Tyr  Gln Pro Gln 
    2120                 2125                 2130             


Ile Ser  Ser Thr Asn Tyr Asn  Thr Leu Thr Leu Asn  Val Lys Thr 
    2135                 2140                 2145             


Gln Glu  Pro Asp Asn Leu Leu  Phe Tyr Leu Gly Ser  Ser Thr Ala 
    2150                 2155                 2160             


Ser Asp  Phe Leu Ala Val Glu  Met Arg Arg Gly Arg  Val Ala Phe 
    2165                 2170                 2175             


Leu Trp  Asp Leu Gly Ser Gly  Ser Thr Arg Leu Glu  Phe Pro Asp 
    2180                 2185                 2190             


Phe Pro  Ile Asp Asp Asn Arg  Trp His Ser Ile His  Val Ala Arg 
    2195                 2200                 2205             


Phe Gly  Asn Ile Gly Ser Leu  Ser Val Lys Glu Met  Ser Ser Asn 
    2210                 2215                 2220             


Gln Lys  Ser Pro Thr Lys Thr  Ser Lys Ser Pro Gly  Thr Ala Asn 
    2225                 2230                 2235             


Val Leu  Asp Val Asn Asn Ser  Thr Leu Met Phe Val  Gly Gly Leu 
    2240                 2245                 2250             


Gly Gly  Gln Ile Lys Lys Ser  Pro Ala Val Lys Val  Thr His Phe 
    2255                 2260                 2265             


Lys Gly  Cys Leu Gly Glu Ala  Phe Leu Asn Gly Lys  Ser Ile Gly 
    2270                 2275                 2280             


Leu Trp  Asn Tyr Ile Glu Arg  Glu Gly Lys Cys Arg  Gly Cys Phe 
    2285                 2290                 2295             


Gly Ser  Ser Gln Asn Glu Asp  Pro Ser Phe His Phe  Asp Gly Ser 
    2300                 2305                 2310             


Gly Tyr  Ser Val Val Glu Lys  Ser Leu Pro Ala Thr  Val Thr Gln 
    2315                 2320                 2325             


Ile Ile  Met Leu Phe Asn Thr  Phe Ser Pro Asn Gly  Leu Leu Leu 
    2330                 2335                 2340             


Tyr Leu  Gly Ser Tyr Gly Thr  Lys Asp Phe Leu Ser  Ile Glu Leu 
    2345                 2350                 2355             


Phe Arg  Gly Arg Val Lys Val  Met Thr Asp Leu Gly  Ser Gly Pro 
    2360                 2365                 2370             


Ile Thr  Leu Leu Thr Asp Arg  Arg Tyr Asn Asn Gly  Thr Trp Tyr 
    2375                 2380                 2385             


Lys Ile  Ala Phe Gln Arg Asn  Arg Lys Gln Gly Val  Leu Ala Val 
    2390                 2395                 2400             


Ile Asp  Ala Tyr Asn Thr Ser  Asn Lys Glu Thr Lys  Gln Gly Glu 
    2405                 2410                 2415             


Thr Pro  Gly Ala Ser Ser Asp  Leu Asn Arg Leu Asp  Lys Asp Pro 
    2420                 2425                 2430             


Ile Tyr  Val Gly Gly Leu Pro  Arg Ser Arg Val Val  Arg Arg Gly 
    2435                 2440                 2445             


Val Thr  Thr Lys Ser Phe Val  Gly Cys Ile Lys Asn  Leu Glu Ile 
    2450                 2455                 2460             


Ser Arg  Ser Thr Phe Asp Leu  Leu Arg Asn Ser Tyr  Gly Val Arg 
    2465                 2470                 2475             


Lys Gly  Cys Leu Leu Glu Pro  Ile Arg Ser Val Ser  Phe Leu Lys 
    2480                 2485                 2490             


Gly Gly  Tyr Ile Glu Leu Pro  Pro Lys Ser Leu Ser  Pro Glu Ser 
    2495                 2500                 2505             


Glu Trp  Leu Val Thr Phe Ala  Thr Thr Asn Ser Ser  Gly Ile Ile 
    2510                 2515                 2520             


Leu Ala  Ala Leu Gly Gly Asp  Val Glu Lys Arg Gly  Asp Arg Glu 
    2525                 2530                 2535             


Glu Ala  His Val Pro Phe Phe  Ser Val Met Leu Ile  Gly Gly Asn 
    2540                 2545                 2550             


Ile Glu  Val His Val Asn Pro  Gly Asp Gly Thr Gly  Leu Arg Lys 
    2555                 2560                 2565             


Ala Leu  Leu His Ala Pro Thr  Gly Thr Cys Ser Asp  Gly Gln Ala 
    2570                 2575                 2580             


His Ser  Ile Ser Leu Val Arg  Asn Arg Arg Ile Ile  Thr Val Gln 
    2585                 2590                 2595             


Leu Asp  Glu Asn Asn Pro Val  Glu Met Lys Leu Gly  Thr Leu Val 
    2600                 2605                 2610             


Glu Ser  Arg Thr Ile Asn Val  Ser Asn Leu Tyr Val  Gly Gly Ile 
    2615                 2620                 2625             


Pro Glu  Gly Glu Gly Thr Ser  Leu Leu Thr Met Arg  Arg Ser Phe 
    2630                 2635                 2640             


His Gly  Cys Ile Lys Asn Leu  Ile Phe Asn Leu Glu  Leu Leu Asp 
    2645                 2650                 2655             


Phe Asn  Ser Ala Val Gly His  Glu Gln Val Asp Leu  Asp Thr Cys 
    2660                 2665                 2670             


Trp Leu  Ser Glu Arg Pro Lys  Leu Ala Pro Asp Ala  Glu Asp Ser 
    2675                 2680                 2685             


Lys Leu  Leu Pro Glu Pro Arg  Ala Phe Pro Glu Gln  Cys Val Val 
    2690                 2695                 2700             


Asp Ala  Ala Leu Glu Tyr Val  Pro Gly Ala His Gln  Phe Gly Leu 
    2705                 2710                 2715             


Thr Gln  Asn Ser His Phe Ile  Leu Pro Phe Asn Gln  Ser Ala Val 
    2720                 2725                 2730             


Arg Lys  Lys Leu Ser Val Glu  Leu Ser Ile Arg Thr  Phe Ala Ser 
    2735                 2740                 2745             


Ser Gly  Leu Ile Tyr Tyr Met  Ala His Gln Asn Gln  Ala Asp Tyr 
    2750                 2755                 2760             


Ala Val  Leu Gln Leu His Gly  Gly Arg Leu His Phe  Met Phe Asp 
    2765                 2770                 2775             


Leu Gly  Lys Gly Arg Thr Lys  Val Ser His Pro Ala  Leu Leu Ser 
    2780                 2785                 2790             


Asp Gly  Lys Trp His Thr Val  Lys Thr Asp Tyr Val  Lys Arg Lys 
    2795                 2800                 2805             


Gly Phe  Ile Thr Val Asp Gly  Arg Glu Ser Pro Met  Val Thr Val 
    2810                 2815                 2820             


Val Gly  Asp Gly Thr Met Leu  Asp Val Glu Gly Leu  Phe Tyr Leu 
    2825                 2830                 2835             


Gly Gly  Leu Pro Ser Gln Tyr  Gln Ala Arg Lys Ile  Gly Asn Ile 
    2840                 2845                 2850             


Thr His  Ser Ile Pro Ala Cys  Ile Gly Asp Val Thr  Val Asn Ser 
    2855                 2860                 2865             


Lys Gln  Leu Asp Lys Asp Ser  Pro Val Ser Ala Phe  Thr Val Asn 
    2870                 2875                 2880             


Arg Cys  Tyr Ala Val Ala Gln  Glu Gly Thr Tyr Phe  Asp Gly Ser 
    2885                 2890                 2895             


Gly Tyr  Ala Ala Leu Val Lys  Glu Gly Tyr Lys Val  Gln Ser Asp 
    2900                 2905                 2910             


Val Asn  Ile Thr Leu Glu Phe  Arg Thr Ser Ser Gln  Asn Gly Val 
    2915                 2920                 2925             


Leu Leu  Gly Ile Ser Thr Ala  Lys Val Asp Ala Ile  Gly Leu Glu 
    2930                 2935                 2940             


Leu Val  Asp Gly Lys Val Leu  Phe His Val Asn Asn  Gly Ala Gly 
    2945                 2950                 2955             


Arg Ile  Thr Ala Ala Tyr Glu  Pro Lys Thr Ala Thr  Val Leu Cys 
    2960                 2965                 2970             


Asp Gly  Lys Trp His Thr Leu  Gln Ala Asn Lys Ser  Lys His Arg 
    2975                 2980                 2985             


Ile Thr  Leu Ile Val Asp Gly  Asn Ala Val Gly Ala  Glu Ser Pro 
    2990                 2995                 3000             


His Thr  Gln Ser Thr Ser Val  Asp Thr Asn Asn Pro  Ile Tyr Val 
    3005                 3010                 3015             


Gly Gly  Tyr Pro Ala Gly Val  Lys Gln Lys Cys Leu  Arg Ser Gln 
    3020                 3025                 3030             


Thr Ser  Phe Arg Gly Cys Leu  Arg Lys Leu Ala Leu  Ile Lys Ser 
    3035                 3040                 3045             


Pro Gln  Val Gln Ser Phe Asp  Phe Ser Arg Ala Phe  Glu Leu His 
    3050                 3055                 3060             


Gly Val  Phe Leu His Ser Cys  Pro Gly Thr Glu Ser  
    3065                 3070                 3075 


<210>  3
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr His Gly Pro Cys Ala Ala Glu Ser Glu Pro Ala Leu Leu Ile Gly 
1               5                   10                  15      


Ser Lys Gln Phe Gly Leu Ser Arg Asn Ser His Ile Ala Ile Ala Phe 
            20                  25                  30          


Asp Asp Thr Lys Val Lys Asn Arg Leu Thr Ile Glu Leu Glu Val Arg 
        35                  40                  45              


Thr Glu Ala Glu Ser Gly Leu Leu Phe Tyr Met Ala Arg Ile Asn His 
    50                  55                  60                  


Ala Asp Phe Ala Thr Val Gln Leu Arg Asn Gly Leu Pro Tyr Phe Ser 
65                  70                  75                  80  


Tyr Asp Leu Gly Ser Gly Asp Thr His Thr Met Ile Pro Thr Lys Ile 
                85                  90                  95      


Asn Asp Gly Gln Trp His Lys Ile Lys Ile Met Arg Ser Lys Gln Glu 
            100                 105                 110         


Gly Ile Leu Tyr Val Asp Gly Ala Ser Asn Arg Thr Ile Ser Pro Lys 
        115                 120                 125             


Lys Ala Asp Ile Leu Asp Val Val Gly Met Leu Tyr Val Gly Gly Leu 
    130                 135                 140                 


Pro Ile Asn Tyr Thr Thr Arg Arg Ile Gly Pro Val Thr Tyr Ser Ile 
145                 150                 155                 160 


Asp Gly Cys Val Arg Asn Leu His Met Ala Glu Ala Pro Ala Asp Leu 
                165                 170                 175     


Glu Gln Pro Thr Ser Ser Phe His Val Gly Thr Cys Phe Ala Asn Ala 
            180                 185                 190         


Gln Arg Gly Thr Tyr Phe Asp Gly Thr Gly Phe Ala Lys Ala Val Gly 
        195                 200                 205             


Gly Phe Lys Val Gly Leu Asp Leu Leu Val Glu Phe Glu Phe Arg Thr 
    210                 215                 220                 


Thr Thr Thr Thr Gly Val Leu Leu Gly Ile Ser Ser Gln Lys Met Asp 
225                 230                 235                 240 


Gly Met Gly Ile Glu Met Ile Asp Glu Lys Leu Met Phe His Val Asp 
                245                 250                 255     


Asn Gly Ala Gly Arg Phe Thr Ala Val Tyr Asp Ala Gly Val Pro Gly 
            260                 265                 270         


His Leu Cys Asp Gly Gln Trp His Lys Val Thr Ala Asn Lys Ile Lys 
        275                 280                 285             


His Arg Ile Glu Leu Thr Val Asp Gly Asn Gln Val Glu Ala Gln Ser 
    290                 295                 300                 


Pro Asn Pro Ala Ser Thr Ser Ala Asp Thr Asn Asp Pro Val Phe Val 
305                 310                 315                 320 


Gly Gly Phe Pro Asp Asp Leu Lys Gln Phe Gly Leu Thr Thr Ser Ile 
                325                 330                 335     


Pro Phe Arg Gly Cys Ile Arg Ser Leu Lys Leu Thr Lys Gly Thr Gly 
            340                 345                 350         


Lys Pro Leu Glu Val Asn Phe Ala Lys Ala Leu Glu Leu Arg Gly Val 
        355                 360                 365             


Gln Pro Val Ser Cys Pro Ala Asn 
    370                 375     


<210>  4
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Pro Glu Leu Cys Ala Val Asp Thr Ala Pro Gly Tyr Val Ala Gly 
1               5                   10                  15      


Ala His Gln Phe Gly Leu Ser Gln Asn Ser His Leu Val Leu Pro Leu 
            20                  25                  30          


Asn Gln Ser Asp Val Arg Lys Arg Leu Gln Val Gln Leu Ser Ile Arg 
        35                  40                  45              


Thr Phe Ala Ser Ser Gly Leu Ile Tyr Tyr Val Ala His Gln Asn Gln 
    50                  55                  60                  


Met Asp Tyr Ala Thr Leu Gln Leu Gln Glu Gly Arg Leu His Phe Met 
65                  70                  75                  80  


Phe Asp Leu Gly Lys Gly Arg Thr Lys Val Ser His Pro Ala Leu Leu 
                85                  90                  95      


Ser Asp Gly Lys Trp His Thr Val Lys Thr Glu Tyr Ile Lys Arg Lys 
            100                 105                 110         


Ala Phe Met Thr Val Asp Gly Gln Glu Ser Pro Ser Val Thr Val Val 
        115                 120                 125             


Gly Asn Ala Thr Thr Leu Asp Val Glu Arg Lys Leu Tyr Leu Gly Gly 
    130                 135                 140                 


Leu Pro Ser His Tyr Arg Ala Arg Asn Ile Gly Thr Ile Thr His Ser 
145                 150                 155                 160 


Ile Pro Ala Cys Ile Gly Glu Ile Met Val Asn Gly Gln Gln Leu Asp 
                165                 170                 175     


Lys Asp Arg Pro Leu Ser Ala Ser Ala Val Asp Arg Cys Tyr Val Val 
            180                 185                 190         


Ala Gln Glu Gly Thr Phe Phe Glu Gly Ser Gly Tyr Ala Ala Leu Val 
        195                 200                 205             


Lys Glu Gly Tyr Lys Val Arg Leu Asp Leu Asn Ile Thr Leu Glu Phe 
    210                 215                 220                 


Arg Thr Thr Ser Lys Asn Gly Val Leu Leu Gly Ile Ser Ser Ala Lys 
225                 230                 235                 240 


Val Asp Ala Ile Gly Leu Glu Ile Val Asp Gly Lys Val Leu Phe His 
                245                 250                 255     


Val Asn Asn Gly Ala Gly Arg Ile Thr Ala Thr Tyr Gln Pro Arg Ala 
            260                 265                 270         


Ala Arg Ala Leu Cys Asp Gly Lys Trp His Thr Leu Gln Ala His Lys 
        275                 280                 285             


Ser Lys His Arg Ile Val Leu Thr Val Asp Gly Asn Ser Val Arg Ala 
    290                 295                 300                 


Glu Ser Pro His Thr His Ser Thr Ser Ala Asp Thr Asn Asp Pro Ile 
305                 310                 315                 320 


Tyr Val Gly Gly Tyr Pro Ala His Ile Lys Gln Asn Cys Leu Ser Ser 
                325                 330                 335     


Arg Ala Ser Phe Arg Gly Cys Val Arg Asn Leu Arg Leu Ser Arg Gly 
            340                 345                 350         


Ser Gln Val Gln Ser Leu Asp Leu Ser Arg Ala Phe Asp Leu Gln Gly 
        355                 360                 365             


Val Phe Pro His Ser Cys Pro Gly Pro Glu Pro 
    370                 375                 


