                         SEQUENCE LISTING

<110>  Auris Medical AG
       Meyer, Thomas
 
<120>  PHARMACOLOGIC TREATMENTS OF MENIERE'S DISEASE

<130>  AURS-006/01WO 320461-2024

<150>  US 62/017,624
<151>  2014-06-26

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  1

Asp Gln Ser Arg Pro Val Gln Pro Phe Leu Asn Leu Thr Thr Pro Arg 
1               5                   10                  15      


Lys Pro Arg 
            


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  2

Asp Gln Ser Arg Pro Val Gln Pro Phe Leu Asn Leu Thr Thr Pro Arg 
1               5                   10                  15      


Lys Pro Arg Pro Pro Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  3

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg 
1               5                   10                  15      


Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp 
            20                  25                  30      


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  4

Arg Pro Lys Arg Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg 
1               5                   10                  15      


Ser Gln Asp 
            


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  5

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  6

Pro Pro Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly 
1               5                   10          


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  7

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  8

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  9

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  10

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  11

Arg Gly Gly Arg Leu Ala Tyr Leu Arg Arg Arg Trp Ala Val Leu Gly 
1               5                   10                  15      


Arg 
    


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  protein transduction domain

<400>  12

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  13

Asp Thr Tyr Arg Pro Lys Arg Pro Thr Thr Leu Asn Leu Phe Pro Gln 
1               5                   10                  15      


Val Pro Arg Ser Gln Asp Thr 
            20              


<210>  14
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  14

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Asp Thr Tyr Arg 
1               5                   10                  15      


Pro Lys Arg Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser 
            20                  25                  30          


Gln Asp Thr 
        35  


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  15

Thr Asp Gln Ser Arg Pro Val Gln Pro Phe Leu Asn Leu Thr Thr Pro 
1               5                   10                  15      


Arg Lys Pro Arg Tyr Thr Asp 
            20              


<210>  16
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  16

Thr Asp Gln Ser Arg Pro Val Gln Pro Phe Leu Asn Leu Thr Thr Pro 
1               5                   10                  15      


Arg Lys Pro Arg Tyr Thr Asp Pro Pro Arg Arg Arg Gln Arg Arg Lys 
            20                  25                  30          


Lys Arg Gly 
        35  


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  17

His Lys His Arg Pro Thr Thr Leu Arg Leu Thr Thr Leu Gly Ala Gln 
1               5                   10                  15      


Asp Ser 
        


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  18

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro His Lys His Arg 
1               5                   10                  15      


Pro Thr Thr Leu Arg Leu Thr Thr Leu Gly Ala Gln Asp Ser 
            20                  25                  30  


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  19

Ser Asp Gln Ala Gly Leu Thr Thr Leu Arg Leu Thr Thr Pro Arg His 
1               5                   10                  15      


Lys His 
        


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  20

Ser Asp Gln Ala Gly Leu Thr Thr Leu Arg Leu Thr Thr Pro Arg His 
1               5                   10                  15      


Lys His Pro Pro Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly 
            20                  25                  30  


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  21

Arg Pro Lys Arg Pro Thr Thr Leu Asn Leu Phe 
1               5                   10      


<210>  22
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  22

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg 
1               5                   10                  15      


Pro Thr Thr Leu Asn Leu Phe 
            20              


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  23

Phe Leu Asn Leu Thr Thr Pro Arg Lys Pro Arg 
1               5                   10      


<210>  24
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  24

Phe Leu Asn Leu Thr Thr Pro Arg Lys Pro Arg Pro Pro Arg Arg Arg 
1               5                   10                  15      


Gln Arg Arg Lys Lys Arg Gly 
            20              


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  25

Arg Pro Lys Arg Pro Lys Thr Leu Asn Leu Phe 
1               5                   10      


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  26

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg 
1               5                   10                  15      


Pro Lys Thr Leu Asn Leu Phe 
            20              


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  27

Phe Leu Asn Leu Thr Lys Pro Arg Lys Pro Arg 
1               5                   10      


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  28

Phe Leu Asn Leu Thr Lys Pro Arg Lys Pro Arg Pro Pro Arg Arg Arg 
1               5                   10                  15      


Gln Arg Arg Lys Lys Arg Gly 
            20              


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  29

Arg Pro Lys Arg Pro Thr Phe Leu Asn Leu Phe 
1               5                   10      


<210>  30
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  30

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg 
1               5                   10                  15      


Pro Thr Phe Leu Asn Leu Phe 
            20              


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  31

Phe Leu Asn Leu Phe Thr Pro Arg Lys Pro Arg 
1               5                   10      


<210>  32
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  32

Phe Leu Asn Leu Phe Thr Pro Arg Lys Pro Arg Pro Pro Arg Arg Arg 
1               5                   10                  15      


Gln Arg Arg Lys Lys Arg Gly 
            20              


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  33

Arg Pro Lys Arg Pro Thr Ser Leu Asn Leu Phe 
1               5                   10      


<210>  34
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  34

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg 
1               5                   10                  15      


Pro Thr Ser Leu Asn Leu Phe 
            20              


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  35

Phe Leu Asn Leu Ser Thr Pro Arg Lys Pro Arg 
1               5                   10      


<210>  36
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  36

Phe Leu Asn Leu Ser Thr Pro Arg Lys Pro Arg Pro Pro Arg Arg Arg 
1               5                   10                  15      


Gln Arg Arg Lys Lys Arg Gly 
            20              


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  37

Arg Pro Lys Arg Pro Thr Thr Leu Asn Leu Asp 
1               5                   10      


<210>  38
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  38

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg 
1               5                   10                  15      


Pro Thr Thr Leu Asn Leu Asp 
            20              


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  39

Asp Leu Asn Leu Thr Thr Pro Arg Lys Pro Arg 
1               5                   10      


<210>  40
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  40

Asp Leu Asn Leu Thr Thr Pro Arg Lys Pro Arg Pro Pro Arg Arg Arg 
1               5                   10                  15      


Gln Arg Arg Lys Lys Arg Gly 
            20              


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  41

Pro Lys Arg Pro Thr Thr Leu Asn Leu Phe 
1               5                   10  


<210>  42
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  42

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Pro Lys Arg Pro 
1               5                   10                  15      


Thr Thr Leu Asn Leu Phe 
            20          


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  43

Phe Leu Asn Leu Thr Thr Pro Arg Lys Pro 
1               5                   10  


<210>  44
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor

<400>  44

Phe Leu Asn Leu Thr Thr Pro Arg Lys Pro Pro Pro Arg Arg Arg Gln 
1               5                   10                  15      


Arg Arg Lys Lys Arg Gly 
            20          


<210>  45
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  JNK peptide inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  May be acetylated

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Residues may be connected by a gamma-aminobutyric acid moiety

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  May be amidated

<400>  45

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ile Leu Lys Gln Ser 
1               5                   10                  15      


Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser Leu Lys Pro His Leu 
            20                  25                  30          


Arg Ala Lys Asn 
        35      


