                         SEQUENCE LISTING

<110>  Rockefeller University
 
<120>  COMPOSITIONS AND METHODS FOR RAPID PRODUCTION OF VERSATILE 
       NANOBODY REPERTOIRES

<130>  076091.00013

<150>  62/017,087
<151>  2014-06-25

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  255
<212>  PRT
<213>  artificial sequence

<220>
<223>  Artificial GFP

<400>  1

Met Ala Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Phe Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val His Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Leu Glu Val Leu Phe Gln Gly Pro Ser His His His His His His 
                245                 250                 255 


<210>  2
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  Artificial GFP

<400>  2

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Leu Glu His His His His His His 
225                 230                 235         


<210>  3
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  Artificial GFP

<400>  3

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Leu Glu His His His His His His 
225                 230                 235         


<210>  4
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  4
gtcctggctg ctcttctaca agg                                               23


<210>  5
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  5
ggtacgtgct gttgaactgt tcc                                               23


<210>  6
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a, c, g, or t

<400>  6
cgtatcgcct ccctcgcgcc atcagatggc tnangtgcag ctggtggagt ctgg             54


<210>  7
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  7
ctatgcgcct tgccagcccg ctcagggaga cggtgacctg ggt                         43


<210>  8
<211>  41
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  8
nnnnnnnnnn nnatggctna ngtgcagctg gtggagtctg g                           41


<210>  9
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  n is a, c, g, or t

<400>  9
nnnnnnnnnn nnggagacgg tgacctgggt                                        30


<210>  10
<211>  127
<212>  PRT
<213>  llama

<400>  10

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Thr Gly Val Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Val Gln Met Asn Ser Leu Ile Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Val Arg Ala Arg Ser Phe Ser Asp Thr Tyr Ser Arg 
            100                 105                 110         


Val Asn Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125         


<210>  11
<211>  124
<212>  PRT
<213>  llama

<400>  11

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Arg Thr Tyr Ser 
            20                  25                  30          


Asp Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Ala Arg Thr Gly Thr Val Leu Phe Thr Ser Arg Val Asp 
            100                 105                 110         


Tyr Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 


<210>  12
<211>  125
<212>  PRT
<213>  llama

<400>  12

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser 
            20                  25                  30          


Ser Asn Ala Met Ala Trp Tyr Arg Gln Thr Pro Glu Lys Gln Arg Glu 
        35                  40                  45              


Leu Ile Cys Asp Ile Thr Arg Gly Gly Ile Thr Lys Cys Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Lys Ser Glu Gly Tyr Phe Gly Phe Pro Arg Val Glu Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125 


<210>  13
<211>  126
<212>  PRT
<213>  llama

<400>  13

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Ala Ala Gly Ile Thr Trp Ile Ser Ser Ser Thr Tyr Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Lys Ser Glu Gly Tyr Phe Gly Phe Pro Arg Val Glu 
            100                 105                 110         


Asn Glu Tyr Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125     


<210>  14
<211>  124
<212>  PRT
<213>  llama

<400>  14

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Gly Tyr Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Arg Glu Arg Glu 
        35                  40                  45              


Ala Val Ala Ala Ile Thr Trp Ser Ala His Ser Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Ile Asp Asn Thr Arg Asn Thr 
65                  70                  75                  80  


Gly Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Val Arg His Gly Thr Trp Phe Thr Thr Ser Arg Tyr Trp 
            100                 105                 110         


Thr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  15
<211>  124
<212>  PRT
<213>  llama

<400>  15

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln His 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Asp 
            20                  25                  30          


Ile His Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp 
        35                  40                  45              


Ile Val Ala Arg Ile Ser Lys Ser Gly Asp Ile Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Thr Leu Arg Ala Thr Ile Thr Ser Phe Asp Glu Tyr 
            100                 105                 110         


Val Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 


<210>  16
<211>  127
<212>  PRT
<213>  llama

<400>  16

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Arg Ile Thr Trp Ser Ala Gly Tyr Thr Ala Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Arg Ser Ala Gly Tyr Ser Ser Ser Leu Thr Arg Arg 
            100                 105                 110         


Glu Asp Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  17
<211>  124
<212>  PRT
<213>  llama

<400>  17

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Gln Leu Ser Cys Ala Phe Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Thr Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Gly Gly Ile Ser Arg Ser Gly Ala Thr Thr Asn Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Asn Asn Ile Leu Pro Val Thr Thr Ile Asp Lys 
            100                 105                 110         


Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 


<210>  18
<211>  128
<212>  PRT
<213>  llama

<400>  18

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Arg Ser Val Arg Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Leu Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Val Thr Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Val Arg Thr Ser Gly Phe Phe Gly Ser Ile Pro Val Thr 
            100                 105                 110         


Glu Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  19
<211>  129
<212>  PRT
<213>  llama

<400>  19

Met Ala Ser Gly Ala Ala Gly Gly Gly Leu Gly Glu Gly Leu Val Gln 
1               5                   10                  15      


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            20                  25                  30          


Asn Ser Tyr Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Ala Leu Gly Trp Ser Gly Gly Ser Thr Asp Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Asp Asp Thr Gly Val 
                85                  90                  95      


Tyr Tyr Cys Ala Leu Arg Arg Arg Gly Gly Val Tyr Asn Thr Tyr Ser 
            100                 105                 110         


Gly Glu Lys Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser 
    


<210>  20
<211>  126
<212>  PRT
<213>  llama

<400>  20

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Ser 
            20                  25                  30          


Ile Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Ala Arg Gly Trp Thr Thr Phe Pro Ala Arg Glu 
            100                 105                 110         


Ile Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125     


<210>  21
<211>  128
<212>  PRT
<213>  llama

<400>  21

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Trp Thr Val Gly Asn Thr Ile Leu Gly Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asp Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Arg Ser Arg Gly Tyr Val Leu Ser Val Leu Arg Ser 
            100                 105                 110         


Val Asp Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  22
<211>  128
<212>  PRT
<213>  llama

<400>  22

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser 
            20                  25                  30          


Met Ala Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Arg Ser Ala Gly Ser Ala Val His Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Val Arg Thr Ser Gly Phe Phe Gly Ser Ile Pro Arg Thr 
            100                 105                 110         


Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  23
<211>  128
<212>  PRT
<213>  llama

<400>  23

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Thr Ala Ser Val Arg Thr Leu Ser 
            20                  25                  30          


Tyr Tyr His Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile His Arg Ser Gly Glu Ser Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gln Arg Val Arg Gly Phe Phe Gly Pro Leu Arg Ser Thr 
            100                 105                 110         


Pro Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  24
<211>  122
<212>  PRT
<213>  llama

<400>  24

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Thr Gly Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Gly 
        35                  40                  45              


Gly Ile Ser Arg Ser Gly Thr Asp Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Asp Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Ser Gln Ile Leu Phe Thr Ser Arg Thr Asp Tyr Glu Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  25
<211>  122
<212>  PRT
<213>  llama

<400>  25

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Thr Gly Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Met Glu Arg Glu Phe Val Gly 
        35                  40                  45              


Gly Ile Ser Gly Ser Glu Thr Asp Thr Tyr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Leu Thr Val Asp Arg Asp Asn Val Lys Asn Thr Val Asp Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Arg Val Thr Leu Phe Thr Ser Arg Ala Asp Tyr Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  26
<211>  117
<212>  PRT
<213>  llama

<400>  26

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Glu Ile Ala Ser 
            20                  25                  30          


Ile Ile Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              


Ser Val Ala Leu Ile Thr Arg Ser Gly Met Ile Thr Tyr Gly Asp Ser 
    50                  55                  60                  


Ala Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu His Met Asp Asp Leu Val Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Lys Lys Val Ser Phe Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser 
        115         


<210>  27
<211>  126
<212>  PRT
<213>  llama

<400>  27

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Ala Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser 
            20                  25                  30          


Leu Tyr His Trp Val Trp Phe Arg Gln Ala Ala Gly Arg Glu His Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ile Arg Ser Gly Gly Glu Thr Leu Ser Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ile Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Met Leu Gln Pro Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Thr His Arg Ala Asp Trp Tyr Ser Ser Ala Phe Arg 
            100                 105                 110         


Glu Tyr Ile Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  28
<211>  125
<212>  PRT
<213>  llama

<400>  28

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Leu Thr Ile Ser 
            20                  25                  30          


Thr Tyr Asn Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Gly Ile Ile Ile Arg Asn Gly Asp Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Val Lys Pro Ala Asp Ala Ala Val Tyr 
                85                  90                  95      


Ser Cys Gly Ala Thr Val Arg Ala Gly Ala Ala Ala Glu Gln Tyr Asn 
            100                 105                 110         


Ser Tyr Ile Phe Arg Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125 


<210>  29
<211>  123
<212>  PRT
<213>  llama

<400>  29

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Ala Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Phe Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Val Ser Ile Ser Arg Ser Gly Gly Gly Thr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Gly Leu Arg Asp Trp Gly Arg Glu Gly Glu Pro His 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120             


<210>  30
<211>  128
<212>  PRT
<213>  llama

<400>  30

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Trp Thr Val Gly Asn Thr Ile Tyr Gly Asp 
    50                  55                  60                  


Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Thr Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Arg Ser Arg Gly Phe Val Leu Ser Asp Leu Arg Ser 
            100                 105                 110         


Val Asp Ser Phe Asp Tyr Lys Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  31
<211>  125
<212>  PRT
<213>  llama

<400>  31

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Trp Thr Gly Gly His Thr Leu Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Ala Ala Asp Phe Phe Ala Gln Arg Asp Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125 


<210>  32
<211>  128
<212>  PRT
<213>  llama

<400>  32

Met Ala Gln Val Gln Phe Val Glu Ser Gly Gly Gly Thr Val Gln Asp 
1               5                   10                  15      


Gly Asp Phe Leu Arg Leu Ser Cys Thr Ala Ser Gly Asp Thr Phe Ser 
            20                  25                  30          


Asn Tyr His Ala Gly Trp Phe Arg Gln Pro Pro Gly Arg Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Thr Gly Glu Gly Thr Leu Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Arg Ser Val Gly Phe Thr Trp Arg Ser Ser Lys 
            100                 105                 110         


Ser Asn Asp Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Gly 
        115                 120                 125             


<210>  33
<211>  121
<212>  PRT
<213>  llama

<400>  33

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Thr Gly Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Gly 
        35                  40                  45              


Gly Ile Ser Gly Ser Glu Thr Asp Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Asp Arg Asp Asn Val Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Arg Ile Thr Leu Phe Thr Ser Arg Thr Asp Tyr Asp Phe 
            100                 105                 110         


Trp Gly Arg Gly Thr Gln Val Thr Val 
        115                 120     


<210>  34
<211>  122
<212>  PRT
<213>  llama

<400>  34

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Thr Gly Ala 
            20                  25                  30          


Met Ala Trp Phe His Gln Gly Leu Gly Lys Glu Arg Glu Phe Val Gly 
        35                  40                  45              


Gly Ile Ser Pro Ser Gly Asp Asn Ile Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Asp Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Met Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Arg Val Thr Leu Phe Thr Ser Arg Thr Asp Tyr Glu Phe 
            100                 105                 110         


Trp Gly Arg Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  35
<211>  128
<212>  PRT
<213>  llama

<400>  35

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Gly Ala Phe Ser 
            20                  25                  30          


Thr Val Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Gly Ala Ile Thr Trp Thr Ala Gly Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gln Arg Val Arg Gly Phe Phe Gly Pro Leu Arg Thr Thr 
            100                 105                 110         


Pro Ser Trp Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  36
<211>  128
<212>  PRT
<213>  llama

<400>  36

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Glu 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Gly Ala Val Ser Trp Gly Gly Gly Arg Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Lys Ser Val Leu Thr Ile Ala Thr Met Arg Val 
            100                 105                 110         


Pro Asp Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  37
<211>  127
<212>  PRT
<213>  llama

<400>  37

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asp Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Ser Gly His Val Thr Asp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Ser Cys Ala Ala Ala Lys Ser Gly Thr Trp Trp Tyr Gln Arg Ser Glu 
            100                 105                 110         


Asn Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  38
<211>  126
<212>  PRT
<213>  llama

<400>  38

Met Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Asp Ile Ala Val Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Ser Gly Leu Ile Ile Asn Tyr Gly Asp 
    50                  55                  60                  


Ser Val Glu Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Ile Gly Met Asn Tyr Tyr Tyr Ala Arg Glu Ile 
            100                 105                 110         


Glu Tyr Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125     


<210>  39
<211>  126
<212>  PRT
<213>  llama

<400>  39

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Phe Ala Glu 
            20                  25                  30          


Ser Ser Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ala Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asn Leu Gly Asn Tyr Ile Ser Ser Asn Gln Arg Leu 
            100                 105                 110         


Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  40
<211>  123
<212>  PRT
<213>  llama

<400>  40

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ala Pro Ser 
            20                  25                  30          


Phe Phe Ala Met Ala Trp Tyr Arg Gln Ser Pro Gly Asn Glu Arg Glu 
        35                  40                  45              


Leu Val Ala Ala Leu Ser Ser Leu Gly Ser Thr Asn Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Met Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Val Asn Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Gly Asp Phe His Ser Cys Tyr Ala Arg Lys Ser Cys Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120             


<210>  41
<211>  122
<212>  PRT
<213>  llama

<400>  41

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Pro Phe Ser 
            20                  25                  30          


Glu Tyr Asn Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Arg Ile Arg Ser Ser Gly Thr Thr Val Tyr Thr Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Ser Ala Ser Arg Asp Asn Ala Lys Asn Met Gly 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Met Ser Arg Val Asp Thr Asp Ser Pro Ala Phe Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120         


<210>  42
<211>  68
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  42
tatgaaatac ttattgccta cggcagccgc tggattgtta ttactcgcgg cccagccggc       60

catggctg                                                                68


<210>  43
<211>  70
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  43
gatccagcca tggccggctg ggccgcgagt aataacaatc cagcggctgc cgtaggcaat       60

aagtatttca                                                              70


