                         SEQUENCE LISTING

<110>  Lygos
 
<120>  Recombinant Host Cells for the Production of Malonate

<130>  20248.19

<150>  62/017,723
<151>  2014-06-26

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  416
<212>  PRT
<213>  Aspergillus niger

<400>  1

Met Asn Val Glu Thr Ser Leu Pro Gly Ser Ser Gly Ser Asp Leu Glu 
1               5                   10                  15      


Thr Phe His His Glu Thr Lys Lys His Ala Asn His Asp Ser Gly Ile 
            20                  25                  30          


Ser Val Asn His Glu Ala Glu Ile Gly Val Asn His Thr Phe Glu Lys 
        35                  40                  45              


Pro Gly Pro Val Gly Ile Arg Glu Arg Leu Arg His Phe Thr Trp Ala 
    50                  55                  60                  


Trp Tyr Thr Leu Thr Met Ser Cys Gly Gly Leu Ala Leu Leu Ile Val 
65                  70                  75                  80  


Asn Gln Pro His Asp Phe Lys Gly Leu Lys Asp Ile Ala Arg Val Val 
                85                  90                  95      


Tyr Cys Leu Asn Leu Ala Phe Phe Val Ile Val Thr Ser Leu Met Ala 
            100                 105                 110         


Ile Arg Phe Ile Leu His Lys Asn Met Trp Glu Ser Leu Gly His Asp 
        115                 120                 125             


Arg Glu Gly Leu Phe Phe Pro Thr Phe Trp Leu Ser Ile Ala Thr Met 
    130                 135                 140                 


Ile Thr Gly Leu Tyr Lys Cys Phe Gly Asp Asp Ala Asn Glu Lys Phe 
145                 150                 155                 160 


Thr Lys Cys Leu Gln Val Leu Phe Trp Ile Tyr Cys Gly Cys Thr Met 
                165                 170                 175     


Ile Thr Ala Val Gly Gln Tyr Ser Phe Val Phe Ala Thr His Lys Tyr 
            180                 185                 190         


Glu Leu His Thr Met Met Pro Ser Trp Ile Leu Pro Ala Phe Pro Val 
        195                 200                 205             


Met Leu Ser Gly Thr Ile Ala Ser Val Ile Gly Ser Gly Gln Pro Ala 
    210                 215                 220                 


Ser Asp Gly Ile Pro Ile Ile Ile Ala Gly Ile Thr Phe Gln Gly Leu 
225                 230                 235                 240 


Gly Phe Ser Ile Ser Phe Met Met Tyr Ala His Tyr Ile Gly Arg Leu 
                245                 250                 255     


Met Glu Val Gly Leu Pro Ser Pro Glu His Arg Pro Gly Met Phe Ile 
            260                 265                 270         


Cys Val Gly Pro Pro Ala Phe Thr Ala Leu Ala Leu Val Gly Met Ala 
        275                 280                 285             


Lys Ala Leu Pro Asp Asp Phe Gln Ile Val Gly Asp Pro His Ala Val 
    290                 295                 300                 


Ile Asp Gly Arg Val Met Leu Phe Leu Ala Val Ser Ala Ala Ile Phe 
305                 310                 315                 320 


Leu Trp Ala Leu Ser Phe Trp Phe Phe Cys Ile Ala Val Val Ala Val 
                325                 330                 335     


Val Arg Ser Pro Pro Lys Gly Phe His Leu Asn Trp Phe Ala Met Val 
            340                 345                 350         


Phe Pro Asn Thr Gly Phe Thr Leu Ala Thr Ile Thr Leu Ala Asn Met 
        355                 360                 365             


Phe Glu Ser Pro Gly Val Lys Gly Val Ala Thr Ala Met Ser Leu Cys 
    370                 375                 380                 


Val Ile Ile Met Phe Ile Phe Val Leu Val Ser Ala Ile Arg Ala Val 
385                 390                 395                 400 


Ile Arg Lys Asp Ile Met Trp Pro Gly Gln Asp Glu Asp Val Ser Glu 
                405                 410                 415     


<210>  2
<211>  416
<212>  PRT
<213>  Aspergillus kawachii

<400>  2

Met Asn Val Glu Thr Ser Leu Pro Gly Ser Ser Gly Ser Asp Leu Glu 
1               5                   10                  15      


Thr Phe His His Glu Thr Lys Lys His Ala Asn His Asp Ser Glu Ile 
            20                  25                  30          


Thr Val Asn His Glu Ala Asp Leu Gly Val Asn His Thr Phe Glu Lys 
        35                  40                  45              


Pro Gly Arg Val Gly Leu Arg Glu Arg Leu Arg His Phe Thr Trp Ala 
    50                  55                  60                  


Trp Tyr Thr Leu Thr Met Ser Cys Gly Gly Leu Ala Leu Leu Ile Val 
65                  70                  75                  80  


Asn Gln Pro His Asp Phe Lys Gly Leu Lys Asp Ile Ala Arg Val Val 
                85                  90                  95      


Tyr Cys Leu Asn Ile Ala Phe Phe Val Ile Val Thr Thr Leu Met Ala 
            100                 105                 110         


Ile Arg Phe Ile Leu His Lys Asn Met Leu Glu Ser Leu Gly His Asp 
        115                 120                 125             


Arg Glu Gly Leu Phe Phe Pro Thr Phe Trp Leu Ser Ile Ala Thr Met 
    130                 135                 140                 


Ile Thr Gly Leu Tyr Lys Cys Phe Gly Asp Asp Ser Asn Glu Lys Phe 
145                 150                 155                 160 


Thr Lys Cys Leu Gln Val Leu Phe Trp Ile Tyr Cys Gly Phe Thr Met 
                165                 170                 175     


Ile Thr Ala Val Ala Gln Tyr Ser Phe Val Phe Ala Thr His Lys Tyr 
            180                 185                 190         


Glu Leu His Thr Met Met Pro Ser Trp Ile Leu Pro Ala Phe Pro Val 
        195                 200                 205             


Met Leu Ser Gly Thr Ile Ala Ser Val Ile Ala Ser Gly Gln Pro Ala 
    210                 215                 220                 


Ser Asp Gly Ile Pro Met Val Ile Ala Gly Ile Thr Phe Gln Gly Leu 
225                 230                 235                 240 


Gly Phe Ser Ile Ser Phe Met Met Tyr Ala His Tyr Ile Gly Arg Leu 
                245                 250                 255     


Met Glu Val Gly Leu Pro Ser Ser Glu His Arg Pro Gly Met Phe Ile 
            260                 265                 270         


Cys Val Gly Pro Pro Ala Phe Thr Ala Leu Ala Leu Val Gly Met Ala 
        275                 280                 285             


Lys Ala Leu Pro Asp Asp Phe Gln Ile Val Gly Asp Pro His Ala Val 
    290                 295                 300                 


Ile Asp Gly Arg Val Met Leu Phe Leu Ala Val Ser Ala Ala Ile Phe 
305                 310                 315                 320 


Leu Trp Ala Leu Ser Phe Trp Phe Phe Cys Ile Ala Val Val Ala Val 
                325                 330                 335     


Val Arg Ser Pro Pro Lys Gly Phe His Leu Asn Trp Phe Ala Met Val 
            340                 345                 350         


Phe Pro Asn Thr Gly Phe Thr Leu Ala Thr Ile Thr Leu Ala Asn Met 
        355                 360                 365             


Phe Glu Ser Pro Gly Val Lys Gly Val Ala Thr Ala Met Ser Leu Cys 
    370                 375                 380                 


Val Ile Ile Met Phe Ile Phe Val Leu Val Ser Ala Ile Arg Ala Val 
385                 390                 395                 400 


Ile Arg Lys Asp Ile Met Trp Pro Gly Gln Asp Glu Asp Val Ser Glu 
                405                 410                 415     


<210>  3
<211>  393
<212>  PRT
<213>  Aspergillus terreus

<400>  3

Met Phe Glu Asn Thr Ala Pro Pro Gly Ser Ser Arg Ser Asp Ser Gly 
1               5                   10                  15      


Ile Leu Asp His Glu Phe Glu Lys Gln Pro Gly Ser Val Gly Met Arg 
            20                  25                  30          


Glu Arg Ile Arg His Phe Thr Trp Ala Trp Tyr Thr Leu Thr Met Ser 
        35                  40                  45              


Ala Gly Gly Leu Ala Leu Leu Leu Gly Ser Gln Pro Asn Thr Phe Thr 
    50                  55                  60                  


Gly Leu Arg Glu Ile Gly Leu Ala Val Tyr Leu Leu Asn Leu Leu Phe 
65                  70                  75                  80  


Phe Ala Leu Val Cys Ser Thr Met Ala Gly Arg Phe Ile Leu His Gly 
                85                  90                  95      


Gly Leu Val Asp Ser Leu Arg His Glu Arg Glu Gly Ile Phe Phe Pro 
            100                 105                 110         


Thr Phe Trp Leu Ser Ile Ala Thr Ile Ile Thr Gly Leu Tyr Arg Tyr 
        115                 120                 125             


Phe Gly Glu Asp Ala Gly Arg Pro Phe Val Leu Ala Leu Glu Ala Leu 
    130                 135                 140                 


Phe Trp Ile Tyr Cys Ala Cys Thr Leu Leu Val Ala Val Ile Gln Tyr 
145                 150                 155                 160 


Ser Trp Leu Phe Ser Gly Pro Lys Tyr Arg Leu Gln Thr Ala Met Pro 
                165                 170                 175     


Gly Trp Ile Leu Pro Ala Phe Pro Val Met Leu Ser Gly Thr Ile Ala 
            180                 185                 190         


Ser Val Ile Ala Glu Gln Gln Pro Ala Arg Ala Ala Ile Pro Ile Ile 
        195                 200                 205             


Val Ala Gly Thr Thr Phe Gln Gly Leu Gly Phe Ser Ile Ser Met Ile 
    210                 215                 220                 


Met Tyr Ala His Tyr Val Gly Arg Leu Met Glu Ser Gly Leu Pro Cys 
225                 230                 235                 240 


Arg Glu His Arg Pro Gly Met Phe Ile Ala Val Gly Pro Pro Ala Phe 
                245                 250                 255     


Thr Ala Leu Ala Leu Val Gly Met Thr Lys Gly Leu Pro His Asp Phe 
            260                 265                 270         


Gln Leu Ile Gly Asp Asp Phe Ala Phe Glu Asp Ala Arg Ile Leu Gln 
        275                 280                 285             


Leu Leu Ala Ile Ala Val Gly Val Phe Leu Trp Ala Leu Ser Leu Trp 
    290                 295                 300                 


Phe Phe Cys Ile Ala Ala Ile Ala Val Val Arg Ser Pro Pro Thr Ala 
305                 310                 315                 320 


Phe His Leu Ser Trp Trp Ala Met Val Phe Pro Asn Thr Gly Phe Thr 
                325                 330                 335     


Leu Ala Thr Ile Asn Leu Gly Thr Ala Leu Lys Ser Glu Gly Ile Gln 
            340                 345                 350         


Gly Val Gly Thr Ala Met Ser Ile Gly Ile Val Ser Ile Phe Leu Phe 
        355                 360                 365             


Val Phe Ile Ser His Val Arg Ala Val Ile Arg Lys Asp Ile Met Tyr 
    370                 375                 380                 


Pro Gly Lys Asp Glu Asp Val Val Glu 
385                 390             


<210>  4
<211>  438
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  4

Met Gly Glu Leu Lys Glu Ile Leu Lys Gln Arg Tyr His Glu Leu Leu 
1               5                   10                  15      


Asp Trp Asn Val Lys Ala Pro His Val Pro Leu Ser Gln Arg Leu Lys 
            20                  25                  30          


His Phe Thr Trp Ser Trp Phe Ala Cys Thr Met Ala Thr Gly Gly Val 
        35                  40                  45              


Gly Leu Ile Ile Gly Ser Phe Pro Phe Arg Phe Tyr Gly Leu Asn Thr 
    50                  55                  60                  


Ile Gly Lys Ile Val Tyr Ile Leu Gln Ile Phe Leu Phe Ser Leu Phe 
65                  70                  75                  80  


Gly Ser Cys Met Leu Phe Arg Phe Ile Lys Tyr Pro Ser Thr Ile Lys 
                85                  90                  95      


Asp Ser Trp Asn His His Leu Glu Lys Leu Phe Ile Ala Thr Cys Leu 
            100                 105                 110         


Leu Ser Ile Ser Thr Phe Ile Asp Met Leu Ala Ile Tyr Ala Tyr Pro 
        115                 120                 125             


Asp Thr Gly Glu Trp Met Val Trp Val Ile Arg Ile Leu Tyr Tyr Ile 
    130                 135                 140                 


Tyr Val Ala Val Ser Phe Ile Tyr Cys Val Met Ala Phe Phe Thr Ile 
145                 150                 155                 160 


Phe Asn Asn His Val Tyr Thr Ile Glu Thr Ala Ser Pro Ala Trp Ile 
                165                 170                 175     


Leu Pro Ile Phe Pro Pro Met Ile Cys Gly Val Ile Ala Gly Ala Val 
            180                 185                 190         


Asn Ser Thr Gln Pro Ala His Gln Leu Lys Asn Met Val Ile Phe Gly 
        195                 200                 205             


Ile Leu Phe Gln Gly Leu Gly Phe Trp Val Tyr Leu Leu Leu Phe Ala 
    210                 215                 220                 


Val Asn Val Leu Arg Phe Phe Thr Val Gly Leu Ala Lys Pro Gln Asp 
225                 230                 235                 240 


Arg Pro Gly Met Phe Met Phe Val Gly Pro Pro Ala Phe Ser Gly Leu 
                245                 250                 255     


Ala Leu Ile Asn Ile Ala Arg Gly Ala Met Gly Ser Arg Pro Tyr Ile 
            260                 265                 270         


Phe Val Gly Ala Asn Ser Ser Glu Tyr Leu Gly Phe Val Ser Thr Phe 
        275                 280                 285             


Met Ala Ile Phe Ile Trp Gly Leu Ala Ala Trp Cys Tyr Cys Leu Ala 
    290                 295                 300                 


Met Val Ser Phe Leu Ala Gly Phe Phe Thr Arg Ala Pro Leu Lys Phe 
305                 310                 315                 320 


Ala Cys Gly Trp Phe Ala Phe Ile Phe Pro Asn Val Gly Phe Val Asn 
                325                 330                 335     


Cys Thr Ile Glu Ile Gly Lys Met Ile Asp Ser Lys Ala Phe Gln Met 
            340                 345                 350         


Phe Gly His Ile Ile Gly Val Ile Leu Cys Ile Gln Trp Ile Leu Leu 
        355                 360                 365             


Met Tyr Leu Met Val Arg Ala Phe Leu Val Asn Asp Leu Cys Tyr Pro 
    370                 375                 380                 


Gly Lys Asp Glu Asp Ala His Pro Pro Pro Lys Pro Asn Thr Gly Val 
385                 390                 395                 400 


Leu Asn Pro Thr Phe Pro Pro Glu Lys Ala Pro Ala Ser Leu Glu Lys 
                405                 410                 415     


Val Asp Thr His Val Thr Ser Thr Gly Gly Glu Ser Asp Pro Pro Ser 
            420                 425                 430         


Ser Glu His Glu Ser Val 
        435             


<210>  5
<211>  431
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  5

Met Asp Ile Val Lys Gln Arg Tyr His Glu Leu Phe Asp Leu Arg Val 
1               5                   10                  15      


Arg Gly Pro Arg Met Lys Met Ala Asp Arg Leu Glu His Phe Thr Trp 
            20                  25                  30          


Ala Trp Phe Ala Ser Ala Met Gly Thr Gly Gly Ile Gly Met Val Thr 
        35                  40                  45              


Ser Leu Tyr His Phe Arg Phe Tyr Gly Leu Asn Thr Leu Gly Lys Ile 
    50                  55                  60                  


Ile Phe Ile Phe Gln Leu Ser Ile Leu Thr Leu Tyr Ile Cys Cys Ile 
65                  70                  75                  80  


Thr Phe Arg Phe Ile Arg Tyr Pro Gly Thr Leu Ser Lys Thr Trp Lys 
                85                  90                  95      


Asn Pro Ser Glu Val Leu Phe Met Pro Thr Ala Leu Leu Ala Ile Ala 
            100                 105                 110         


Thr Ser Ile Ser Asn Leu Tyr Pro Tyr Ala Phe Pro Tyr Thr Gly Glu 
        115                 120                 125             


Trp Met Val Trp Leu Ile Arg Ile Leu Tyr Trp Ile Phe Val Ala Val 
    130                 135                 140                 


Ala Cys Ile Phe Val Ile Ser Leu Phe Tyr Ser Leu Phe His Ala His 
145                 150                 155                 160 


Pro Phe Arg Ile Asn Thr Ile Ile Pro Ala Leu Val Leu Pro Ile Phe 
                165                 170                 175     


Pro Cys Met Ile Cys Gly Val Ile Ala Ser Ala Ile Val Glu Ser Gln 
            180                 185                 190         


Pro Ala Arg Gln Ala Lys Asn Met Val Val Ala Gly Ile Ala Phe Gln 
        195                 200                 205             


Gly Leu Gly Phe Trp Ile Tyr Ile Ile Val Tyr Ala Val Asn Met Cys 
    210                 215                 220                 


Arg Phe Phe Thr Val Gly Leu Gln Pro Ala Ala Asp Arg Pro Gly Met 
225                 230                 235                 240 


Phe Ile Leu Val Ser Pro Pro Ser Phe Thr Gly Leu Thr Leu Leu Asp 
                245                 250                 255     


Leu Ala Phe Gly Ala Lys Ala Lys Arg Pro Tyr Ile Phe Val Gly Asp 
            260                 265                 270         


Asn Ser Ser Glu Tyr Leu Glu Phe Val Ala Thr Phe Met Ala Leu Phe 
        275                 280                 285             


Met Ile Gly Leu Gly Ile Phe Asn Phe Cys Leu Ala Phe Val Ser Val 
    290                 295                 300                 


Val Ala Gly Phe Cys Thr Arg Gln Arg Ile Lys Phe Lys Val Ser Trp 
305                 310                 315                 320 


Phe Ala Met Ile Phe Ala Asn Val Gly Leu Val Met Asp Val Gln Glu 
                325                 330                 335     


Leu Gly Arg Ala Ile Asp Ser Lys Ala Val Cys Ile Val Gly Gln Val 
            340                 345                 350         


Cys Gly Val Thr Ile Thr Ile Val Trp Ile Ile Leu Ile Leu Leu Thr 
        355                 360                 365             


Leu Arg Ala Val Tyr Val Gln Glu Leu Leu Tyr Pro Gly Lys Asp Glu 
    370                 375                 380                 


Asp Ile Asp Thr Ile Leu Pro Asn Val Leu Glu Tyr Tyr Arg His Leu 
385                 390                 395                 400 


Glu Glu Glu Glu Lys Asp Glu Ala Glu Arg Ser Lys Arg Lys Ala Glu 
                405                 410                 415     


Glu Ser Asp Gly Lys Thr Thr Arg Glu Leu Thr Ser Gly Gly Leu 
            420                 425                 430     


<210>  6
<211>  392
<212>  PRT
<213>  Aspergillus clavatus

<400>  6

Met Phe Glu Asn Arg Ile Pro Pro Thr Ser Ser Gln Ser Asp Ser Gly 
1               5                   10                  15      


Phe Leu Glu Asn Gln Leu Glu Lys Gln His Arg Leu Ser Leu Arg Glu 
            20                  25                  30          


Arg Leu Arg His Phe Thr Trp Ala Trp Tyr Thr Leu Thr Met Ser Thr 
        35                  40                  45              


Gly Gly Leu Ala Leu Leu Ile Ala Ser Gln Pro Tyr Thr Phe Lys Gly 
    50                  55                  60                  


Leu Lys Thr Ile Gly Leu Val Val Tyr Ile Val Asn Leu Ile Leu Phe 
65                  70                  75                  80  


Gly Leu Val Cys Ser Leu Met Ala Thr Arg Phe Ile Leu His Gly Gly 
                85                  90                  95      


Phe Leu Asp Ser Leu Arg His Glu Arg Glu Gly Leu Phe Phe Pro Thr 
            100                 105                 110         


Phe Trp Leu Ser Val Ala Thr Ile Ile Thr Gly Leu His Arg Tyr Phe 
        115                 120                 125             


Gly Ser Asp Ala Arg Glu Ser Tyr Leu Ile Ala Leu Glu Val Leu Phe 
    130                 135                 140                 


Trp Val Tyr Cys Ala Cys Thr Leu Ala Thr Ala Val Ile Gln Tyr Ser 
145                 150                 155                 160 


Phe Ile Phe Ser Ala His Arg Tyr Gly Leu Gln Thr Met Met Pro Ser 
                165                 170                 175     


Trp Ile Leu Pro Ala Phe Pro Ile Met Leu Ser Gly Thr Ile Ala Ser 
            180                 185                 190         


Val Ile Gly Glu Ala Gln Pro Ala Arg Ser Ser Ile Pro Val Ile Met 
        195                 200                 205             


Ala Gly Val Thr Phe Gln Gly Leu Gly Phe Ser Ile Ser Phe Met Met 
    210                 215                 220                 


Tyr Ala His Tyr Ile Gly Arg Leu Met Glu Ser Gly Leu Pro Cys Arg 
225                 230                 235                 240 


Glu His Arg Pro Gly Met Phe Ile Cys Val Gly Pro Pro Ala Phe Thr 
                245                 250                 255     


Ala Leu Ala Leu Val Gly Met Ala Lys Gly Leu Pro Ala Glu Phe Lys 
            260                 265                 270         


Leu Ile Asn Asp Ala His Ala Leu Glu Asp Ala Arg Ile Leu Glu Leu 
        275                 280                 285             


Leu Ala Ile Thr Ala Gly Ile Phe Leu Trp Ala Leu Ser Leu Trp Phe 
    290                 295                 300                 


Phe Phe Ile Ala Val Ile Ala Val Leu Arg Ser Pro Pro Thr Ser Phe 
305                 310                 315                 320 


His Leu Asn Trp Trp Ala Leu Val Phe Pro Asn Thr Gly Phe Thr Leu 
                325                 330                 335     


Ala Thr Ile Thr Leu Gly Lys Ala Leu Gly Ser Pro Gly Ile Leu Gly 
            340                 345                 350         


Val Gly Ser Ala Met Ser Leu Gly Ile Val Gly Met Trp Leu Phe Val 
        355                 360                 365             


Phe Val Ser His Ile Arg Ala Ile Ile Asn Gln Asp Ile Met Tyr Pro 
    370                 375                 380                 


Gly Lys Asp Glu Asp Ala Ala Asp 
385                 390         


<210>  7
<211>  416
<212>  PRT
<213>  Aspergillis


<220>
<221>  VARIANT
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (15)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (41)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (90)..(90)
<223>  Arg, Lys, His

<220>
<221>  VARIANT
<222>  (91)..(91)
<223>  Asp, Glu

<220>
<221>  VARIANT
<222>  (93)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (101)..(101)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (105)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (106)..(106)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (108)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (109)..(109)
<223>  Ser, Thr

<220>
<221>  VARIANT
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (119)..(120)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (121)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (123)..(123)
<223>  Asp, Glu

<220>
<221>  VARIANT
<222>  (126)..(126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (128)..(128)
<223>  Asp, Glu

<220>
<221>  VARIANT
<222>  (132)..(132)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (144)..(144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (150)..(150)
<223>  Arg, Lys, His

<220>
<221>  VARIANT
<222>  (151)..(151)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (154)..(154)
<223>  Asp, Glu

<220>
<221>  VARIANT
<222>  (156)..(159)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (161)..(163)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (165)..(166)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (173)..(174)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (176)..(176)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (181)..(181)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (185)..(185)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (186)..(186)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (188)..(190)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (193)..(193)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (195)..(195)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (200)..(200)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (219)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (225)..(227)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (230)..(230)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (231)..(232)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (235)..(235)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (246)..(247)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (253)..(253)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (259)..(259)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (263)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (273)..(273)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (290)..(290)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (293)..(293)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (297)..(298)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (301)..(302)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (304)..(305)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (307)..(307)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (309)..(309)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (310)..(312)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (315)..(315)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (316)..(318)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (319)..(319)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (326)..(326)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (333)..(333)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (334)..(334)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (342)..(343)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (347)..(347)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (349)..(349)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (364)..(364)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (366)..(370)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (372)..(372)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (374)..(374)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (375)..(375)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (378)..(378)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (383)..(383)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (384)..(384)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (385)..(386)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (387)..(388)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (390)..(390)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (393)..(393)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (394)..(394)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (396)..(396)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (397)..(397)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (407)..(407)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (410)..(410)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (415)..(415)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Xaa Xaa Xaa Xaa Thr Xaa Xaa Pro Gly Ser Ser Xaa Ser Asp Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Pro Gly Xaa Val Gly Xaa Arg Glu Arg Xaa Arg His Phe Thr Trp Ala 
    50                  55                  60                  


Trp Tyr Thr Leu Thr Met Ser Xaa Gly Gly Leu Ala Leu Leu Xaa Xaa 
65                  70                  75                  80  


Xaa Gln Pro Xaa Xaa Phe Xaa Gly Leu Xaa Xaa Ile Xaa Xaa Xaa Val 
                85                  90                  95      


Tyr Xaa Leu Asn Xaa Xaa Phe Phe Xaa Xaa Val Xaa Xaa Xaa Met Ala 
            100                 105                 110         


Xaa Arg Phe Ile Leu His Xaa Xaa Xaa Xaa Xaa Ser Leu Xaa His Xaa 
        115                 120                 125             


Arg Glu Gly Xaa Phe Phe Pro Thr Phe Trp Leu Ser Ile Ala Thr Xaa 
    130                 135                 140                 


Ile Thr Gly Leu Tyr Xaa Xaa Phe Gly Xaa Asp Xaa Xaa Xaa Xaa Phe 
145                 150                 155                 160 


Xaa Xaa Xaa Leu Xaa Xaa Leu Phe Trp Ile Tyr Cys Xaa Xaa Thr Xaa 
                165                 170                 175     


Xaa Xaa Ala Val Xaa Gln Tyr Ser Xaa Xaa Phe Xaa Xaa Xaa Lys Tyr 
            180                 185                 190         


Xaa Leu Xaa Thr Xaa Met Pro Xaa Trp Ile Leu Pro Ala Phe Pro Val 
        195                 200                 205             


Met Leu Ser Gly Thr Ile Ala Ser Val Ile Xaa Xaa Xaa Gln Pro Ala 
    210                 215                 220                 


Xaa Xaa Xaa Ile Pro Xaa Xaa Xaa Ala Gly Xaa Thr Phe Gln Gly Leu 
225                 230                 235                 240 


Gly Phe Ser Ile Ser Xaa Xaa Met Tyr Ala His Tyr Xaa Gly Arg Leu 
                245                 250                 255     


Met Glu Xaa Gly Leu Pro Xaa Xaa Glu His Arg Pro Gly Met Phe Ile 
            260                 265                 270         


Xaa Val Gly Pro Pro Ala Phe Thr Ala Leu Ala Leu Val Gly Met Xaa 
        275                 280                 285             


Lys Xaa Leu Pro Xaa Asp Phe Gln Xaa Xaa Gly Asp Xaa Xaa Ala Xaa 
    290                 295                 300                 


Xaa Asp Xaa Arg Xaa Xaa Xaa Xaa Leu Ala Xaa Xaa Xaa Xaa Xaa Phe 
305                 310                 315                 320 


Leu Trp Ala Leu Ser Xaa Trp Phe Phe Cys Ile Ala Xaa Xaa Ala Val 
                325                 330                 335     


Val Arg Ser Pro Pro Xaa Xaa Phe His Leu Xaa Trp Xaa Ala Met Val 
            340                 345                 350         


Phe Pro Asn Thr Gly Phe Thr Leu Ala Thr Ile Xaa Leu Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Ser Xaa Gly Xaa Xaa Gly Val Xaa Thr Ala Met Ser Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Phe Xaa Phe Val Xaa Xaa Ser Xaa Xaa Arg Ala Val 
385                 390                 395                 400 


Ile Arg Lys Asp Ile Met Xaa Pro Gly Xaa Asp Glu Asp Val Xaa Glu 
                405                 410                 415     


<210>  8
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence based on Aspergillus and Schizosaccharomyces pombe MAE1 
       transport proteins.


<220>
<221>  VARIANT
<222>  (1)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (24)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (41)..(41)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (49)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (54)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (59)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (62)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (73)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (76)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (80)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (85)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (89)..(89)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (90)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (100)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (106)..(106)
<223>  Ser, Thr

<220>
<221>  VARIANT
<222>  (107)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (114)..(114)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (116)..(117)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (119)..(120)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (124)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (126)..(126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (128)..(129)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (131)..(145)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (146)..(146)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (147)..(148)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (150)..(151)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (153)..(158)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (159)..(159)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (160)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (162)..(162)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (163)..(166)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (167)..(167)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (169)..(174)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (175)..(175)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (176)..(176)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (178)..(179)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (181)..(182)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (183)..(183)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (186)..(186)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (189)..(189)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (191)..(191)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (192)..(192)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (194)..(194)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (197)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (199)..(199)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (200)..(202)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (206)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (212)..(213)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (216)..(217)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (225)..(225)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (226)..(230)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (232)..(235)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (237)..(240)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (243)..(247)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (253)..(254)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (256)..(256)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (259)..(259)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (261)..(261)
<223>  Ser, Thr

<220>
<221>  VARIANT
<222>  (262)..(262)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (264)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (266)..(266)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (267)..(278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (279)..(279)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (281)..(293)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (294)..(294)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (295)..(299)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (300)..(300)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (302)..(304)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (306)..(310)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (312)..(312)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (314)..(314)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (315)..(315)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (316)..(317)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (318)..(318)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (319)..(324)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (326)..(328)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (330)..(330)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (332)..(332)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (333)..(333)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (335)..(335)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (337)..(337)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (339)..(345)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (346)..(346)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (347)..(351)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (353)..(363)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (364)..(364)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (365)..(365)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (366)..(366)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (367)..(370)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (371)..(371)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (372)..(372)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (373)..(373)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (374)..(377)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (378)..(378)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (381)..(384)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (385)..(385)
<223>  Asp, Glu

<220>
<221>  VARIANT
<222>  (386)..(386)
<223>  Ile, Leu, Val

<220>
<221>  VARIANT
<222>  (387)..(388)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (391)..(391)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (395)..(397)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa His Phe Thr Trp Xaa Trp 
        35                  40                  45              


Xaa Xaa Xaa Xaa Met Xaa Xaa Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Phe Xaa Gly Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Arg Phe Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu 
            100                 105                 110         


Xaa Xaa Phe Xaa Xaa Thr Xaa Xaa Leu Xaa Ile Xaa Thr Xaa Ile Xaa 
        115                 120                 125             


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Leu Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Thr Xaa Xaa Pro Xaa Xaa Xaa Leu Pro Xaa Phe Pro Xaa Met Xaa Xaa 
            180                 185                 190         


Gly Xaa Ile Ala Xaa Xaa Xaa Xaa Xaa Xaa Gln Pro Ala Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Phe Gln Gly Leu Gly Phe Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Gly Leu Xaa Xaa Xaa Xaa Xaa Arg Pro Gly Met Phe Xaa Xaa Val Xaa 
                245                 250                 255     


Pro Pro Xaa Phe Xaa Xaa Leu Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa 
    290                 295                 300                 


Leu Xaa Xaa Xaa Xaa Xaa Cys Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Trp Xaa Ala Xaa Xaa Phe Xaa Asn 
                325                 330                 335     


Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Ala Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Pro Gly Xaa Asp Glu Asp Xaa Xaa Xaa 
385                 390                 395         


