                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  A DENGUE VIRUS CHIMERIC POLYEPITOPE COMPOSED OF FRAGMENTS OF 
       NON-STRUCTURAL PROTEINS AND ITS USE IN AN IMMUNOGENIC COMPOSITION
       AGAINST DENGUE VIRUS INFECTION

<130>  B10753A AD/DP/AM

<140>  PCT/EPXXXXXX
<141>  2015-06-22

<150>  EP14305984.8
<151>  2014-06-23

<160>  152   

<170>  PatentIn version 3.5

<210>  1
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       chimeric polyepitope of DENV1

<400>  1
gcatcacaag aagggcccct accagagatt gaagatgagg tgtttaggaa aagaaactta       60

acaataatgg acctacatcc aggatcaggg aaaacaagaa gatatctccc agccatagtc      120

cgtgaggcca taaaaaggaa gctgcgcaca ctaattttgg ctcccacaag ggttgtcgct      180

tccgaaatgg cagaggcgct caagggaatg ccaataaggt accaaacaac agcagtgaag      240

agtgaacaca caggaaaaga gatagttgac ctcatgtgcc acgccacttt caccatgcgt      300

ctcctgtctc ccgtgagagt tcccaattac aacatgatta ttatggatga agcacatttc      360

accgatccat ccagtatagc agccagaggg tacatctcaa cccgagtggg catgggtgaa      420

gcagctgcga tcttcatgac agccactcct ccaggatcag tggaggcctt tccacagagc      480

aatgcagtta tccaagatga ggaaagagac attcctgaga gatcatggaa ctcaggatat      540

gagtggatca ctgacgagga ccatgctcat tggacagaag caaaaatgct ccttgacaac      600

ataaacacac cagaaggaat tatcccagct ctctttgagc cggagagaga aaagagtgca      660

gcaatagacg gggagtacag actgcgggga gaagcaagga aaacgttcgt ggagctcatg      720

agaagaggag atttaccagt ttggctatct tacaaagttg cctcagaagg cttccaatac      780

tccgatagaa ggtggtgctt tgatggagaa aggaacaacc aggtgttgga ggaaaacatg      840

gacgtggaga tctggacaaa ggagggagaa agaaagaaat tacgaccccg ctggttggac      900

gccagaacat actctgatcc actggccctg cgcgagttca aagagttcgc agcaggagtg      960

gctgttgaaa atcaccacca tgccgcaatg ctggacgtag acttacatcc agcttcagcc     1020

tggaccctct atgcagtggc cacaacaatt atcactccca tgatgaggca cacaatagaa     1080

aacacaacgg caaacatttc cctgacagcc attgcaaacc aggcggctat attgatggga     1140

cttgacaaag gatggccaat atcgaagatg gacataggag ttccacttct cgccttgggg     1200

tgctattccc aggtgctgga tatcattggc cagaggatag agaacataaa acatgaacat     1260

aagtcaacat ggcattatga tgaggacaat ccatataaaa catgggccta tcacggatca     1320

tatgaggtca agccatcagg atcagcctca tccatggtca atggcgtggt gaaactgctc     1380

accaaaccat gggatgtcat ccccatggtc acacaaatag ccatgactga caccacaccc     1440

tttggacaac agagggtgtt caaagagaaa gttgacacgc gcacaccaaa agcaaaacga     1500

ggcacagcac aaatcatgga ggtgacagcc aaatggttat ggggttttct ttctagaaac     1560

aaaaaaccaa gaatttgtac aagagaggag ttcacaagaa aagtcaggtc aaacgca        1617


<210>  2
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised nucleotide sequence of the polynucleotide encoding the 
       chimeric polyepitope of DENV1 (human codon optimised, measles 
       optimised)

<400>  2
gcatcacagg agggaccact gcccgaaatt gaggacgaag tgtttagaaa gcgaaatctg       60

actattatgg acctgcaccc cggatctggc aagacccgga gatacctgcc agccatcgtg      120

agggaggcta ttaagcggaa actgagaaca ctgatcctgg ccccaactcg cgtggtcgct      180

tccgaaatgg ctgaggccct gaaaggcatg cccatccggt atcagaccac agcagtgaag      240

tctgaacata ccggcaagga gattgtggac ctgatgtgcc acgccacttt caccatgcga      300

ctgctgagcc cagtgcgggt ccccaactac aatatgatca ttatggacga ggcccacttt      360

actgatccca gctccatcgc cgctagagga tatatttcca ccagggtggg aatgggcgag      420

gcagcagcta tcttcatgac agcaactccc cctggcagcg tggaggcatt tcctcagtcc      480

aacgccgtca tccaggacga ggagcgggac attcctgagc ggagctggaa ttctgggtac      540

gaatggatca cagacgagga tcatgcacac tggactgaag ccaagatgct gctggacaac      600

attaatactc ctgagggaat cattccagct ctgttcgagc ccgaaagaga gaagtctgca      660

gccatcgacg gcgagtatag actgagggga gaggcccgga agaccttcgt ggaactgatg      720

aggcgcggcg atctgcccgt gtggctgagt tacaaggtcg cttcagaggg attccagtat      780

agtgaccgac ggtggtgctt tgatggcgaa cgcaacaatc aggtgctgga ggagaacatg      840

gatgtcgaga tttggacaaa ggaaggcgag cggaagaaac tgcgcccacg atggctggac      900

gctcggactt acagcgatcc cctggcactg agagaattca aagagtttgc tgcaggggtg      960

gccgtcgaga atcaccatca cgccgctatg ctggacgtgg atctgcatcc tgccagtgct     1020

tggaccctgt atgcagtggc cactaccatc attaccccaa tgatgcgcca cacaatcgag     1080

aacacaactg ccaatatctc actgacagct attgcaaacc aggcagccat tctgatggga     1140

ctggacaaag gctggcccat cagcaagatg gatattggcg tgcctctgct ggccctgggg     1200

tgttacagtc aggtgctgga catcattggc cagaggatcg agaacattaa gcatgagcac     1260

aaatcaacct ggcattacga cgaagataat ccctataaga catgggccta ccacggaagc     1320

tatgaggtga aaccttcagg cagcgccagc agcatggtca acggggtggt caagctgctg     1380

accaaacctt gggacgtgat cccaatggtc actcagattg ccatgaccga taccacccca     1440

ttcggccagc agcgggtgtt caaggagaag gtggacaccc gcacacctaa ggctaaacga     1500

gggactgcac agatcatgga ggtgaccgcc aagtggctgt ggggattcct gtccaggaac     1560

aagaagccaa gaatctgtac cagggaagag ttcacaagaa aggtccggtc aaacgcc        1617


<210>  3
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the chimeric polyepitope of DENV1

<400>  3

Ala Ser Gln Glu Gly Pro Leu Pro Glu Ile Glu Asp Glu Val Phe Arg 
1               5                   10                  15      


Lys Arg Asn Leu Thr Ile Met Asp Leu His Pro Gly Ser Gly Lys Thr 
            20                  25                  30          


Arg Arg Tyr Leu Pro Ala Ile Val Arg Glu Ala Ile Lys Arg Lys Leu 
        35                  40                  45              


Arg Thr Leu Ile Leu Ala Pro Thr Arg Val Val Ala Ser Glu Met Ala 
    50                  55                  60                  


Glu Ala Leu Lys Gly Met Pro Ile Arg Tyr Gln Thr Thr Ala Val Lys 
65                  70                  75                  80  


Ser Glu His Thr Gly Lys Glu Ile Val Asp Leu Met Cys His Ala Thr 
                85                  90                  95      


Phe Thr Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn Met 
            100                 105                 110         


Ile Ile Met Asp Glu Ala His Phe Thr Asp Pro Ser Ser Ile Ala Ala 
        115                 120                 125             


Arg Gly Tyr Ile Ser Thr Arg Val Gly Met Gly Glu Ala Ala Ala Ile 
    130                 135                 140                 


Phe Met Thr Ala Thr Pro Pro Gly Ser Val Glu Ala Phe Pro Gln Ser 
145                 150                 155                 160 


Asn Ala Val Ile Gln Asp Glu Glu Arg Asp Ile Pro Glu Arg Ser Trp 
                165                 170                 175     


Asn Ser Gly Tyr Glu Trp Ile Thr Asp Glu Asp His Ala His Trp Thr 
            180                 185                 190         


Glu Ala Lys Met Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile 
        195                 200                 205             


Pro Ala Leu Phe Glu Pro Glu Arg Glu Lys Ser Ala Ala Ile Asp Gly 
    210                 215                 220                 


Glu Tyr Arg Leu Arg Gly Glu Ala Arg Lys Thr Phe Val Glu Leu Met 
225                 230                 235                 240 


Arg Arg Gly Asp Leu Pro Val Trp Leu Ser Tyr Lys Val Ala Ser Glu 
                245                 250                 255     


Gly Phe Gln Tyr Ser Asp Arg Arg Trp Cys Phe Asp Gly Glu Arg Asn 
            260                 265                 270         


Asn Gln Val Leu Glu Glu Asn Met Asp Val Glu Ile Trp Thr Lys Glu 
        275                 280                 285             


Gly Glu Arg Lys Lys Leu Arg Pro Arg Trp Leu Asp Ala Arg Thr Tyr 
    290                 295                 300                 


Ser Asp Pro Leu Ala Leu Arg Glu Phe Lys Glu Phe Ala Ala Gly Val 
305                 310                 315                 320 


Ala Val Glu Asn His His His Ala Ala Met Leu Asp Val Asp Leu His 
                325                 330                 335     


Pro Ala Ser Ala Trp Thr Leu Tyr Ala Val Ala Thr Thr Ile Ile Thr 
            340                 345                 350         


Pro Met Met Arg His Thr Ile Glu Asn Thr Thr Ala Asn Ile Ser Leu 
        355                 360                 365             


Thr Ala Ile Ala Asn Gln Ala Ala Ile Leu Met Gly Leu Asp Lys Gly 
    370                 375                 380                 


Trp Pro Ile Ser Lys Met Asp Ile Gly Val Pro Leu Leu Ala Leu Gly 
385                 390                 395                 400 


Cys Tyr Ser Gln Val Leu Asp Ile Ile Gly Gln Arg Ile Glu Asn Ile 
                405                 410                 415     


Lys His Glu His Lys Ser Thr Trp His Tyr Asp Glu Asp Asn Pro Tyr 
            420                 425                 430         


Lys Thr Trp Ala Tyr His Gly Ser Tyr Glu Val Lys Pro Ser Gly Ser 
        435                 440                 445             


Ala Ser Ser Met Val Asn Gly Val Val Lys Leu Leu Thr Lys Pro Trp 
    450                 455                 460                 


Asp Val Ile Pro Met Val Thr Gln Ile Ala Met Thr Asp Thr Thr Pro 
465                 470                 475                 480 


Phe Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg Thr Pro 
                485                 490                 495     


Lys Ala Lys Arg Gly Thr Ala Gln Ile Met Glu Val Thr Ala Lys Trp 
            500                 505                 510         


Leu Trp Gly Phe Leu Ser Arg Asn Lys Lys Pro Arg Ile Cys Thr Arg 
        515                 520                 525             


Glu Glu Phe Thr Arg Lys Val Arg Ser Asn Ala 
    530                 535                 


<210>  4
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       first region of NS3 of DENV1

<400>  4
gcatcacaag aagggcccct accagagatt gaagatgagg tgtttaggaa aagaaactta       60

acaataatgg acctacatcc aggatcaggg aaaacaagaa gatatctccc agccatagtc      120

cgtgaggcca taaaaaggaa gctgcgcaca ctaattttgg ctcccacaag ggttgtcgct      180

tccgaaatgg cagaggcgct caagggaatg ccaataaggt accaaacaac agcagtgaag      240

agtgaacaca caggaaaaga gatagttgac ctcatgtgcc acgccacttt caccatgcgt      300

ctcctgtctc ccgtgagagt tcccaattac aacatgatta ttatggatga agcacatttc      360

accgatccat ccagtatagc agccagaggg tacatctcaa cccgagtggg catgggtgaa      420

gcagctgcga tcttcatgac agccactcct ccaggatcag tggaggcctt tccacagagc      480

aatgcagtta tccaagatga ggaaagagac attcctgaga gatcatggaa ctcaggatat      540

gagtggatca ctgac                                                       555


<210>  5
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised nucleotide sequence of the polynucleotide encoding the 
       first region of NS3 of DENV1

<400>  5
gcatcacagg agggaccact gcccgaaatt gaggacgaag tgtttagaaa gcgaaatctg       60

actattatgg acctgcaccc cggatctggc aagacccgga gatacctgcc agccatcgtg      120

agggaggcta ttaagcggaa actgagaaca ctgatcctgg ccccaactcg cgtggtcgct      180

tccgaaatgg ctgaggccct gaaaggcatg cccatccggt atcagaccac agcagtgaag      240

tctgaacata ccggcaagga gattgtggac ctgatgtgcc acgccacttt caccatgcga      300

ctgctgagcc cagtgcgggt ccccaactac aatatgatca ttatggacga ggcccacttt      360

actgatccca gctccatcgc cgctagagga tatatttcca ccagggtggg aatgggcgag      420

gcagcagcta tcttcatgac agcaactccc cctggcagcg tggaggcatt tcctcagtcc      480

aacgccgtca tccaggacga ggagcgggac attcctgagc ggagctggaa ttctgggtac      540

gaatggatca cagac                                                       555


<210>  6
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the first region of NS3 of DENV1

<400>  6

Ala Ser Gln Glu Gly Pro Leu Pro Glu Ile Glu Asp Glu Val Phe Arg 
1               5                   10                  15      


Lys Arg Asn Leu Thr Ile Met Asp Leu His Pro Gly Ser Gly Lys Thr 
            20                  25                  30          


Arg Arg Tyr Leu Pro Ala Ile Val Arg Glu Ala Ile Lys Arg Lys Leu 
        35                  40                  45              


Arg Thr Leu Ile Leu Ala Pro Thr Arg Val Val Ala Ser Glu Met Ala 
    50                  55                  60                  


Glu Ala Leu Lys Gly Met Pro Ile Arg Tyr Gln Thr Thr Ala Val Lys 
65                  70                  75                  80  


Ser Glu His Thr Gly Lys Glu Ile Val Asp Leu Met Cys His Ala Thr 
                85                  90                  95      


Phe Thr Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn Met 
            100                 105                 110         


Ile Ile Met Asp Glu Ala His Phe Thr Asp Pro Ser Ser Ile Ala Ala 
        115                 120                 125             


Arg Gly Tyr Ile Ser Thr Arg Val Gly Met Gly Glu Ala Ala Ala Ile 
    130                 135                 140                 


Phe Met Thr Ala Thr Pro Pro Gly Ser Val Glu Ala Phe Pro Gln Ser 
145                 150                 155                 160 


Asn Ala Val Ile Gln Asp Glu Glu Arg Asp Ile Pro Glu Arg Ser Trp 
                165                 170                 175     


Asn Ser Gly Tyr Glu Trp Ile Thr Asp 
            180                 185 


<210>  7
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       second region of NS3 of DENV1

<400>  7
gaggaccatg ctcattggac agaagcaaaa atgctccttg acaacataaa cacaccagaa       60

ggaattatcc cagctctctt tgagccggag agagaaaaga gtgcagcaat agacggggag      120

tacagactgc ggggagaagc aaggaaaacg ttcgtggagc tcatgagaag aggagattta      180

ccagtttggc tatcttacaa agttgcctca gaaggcttcc aatactccga tagaaggtgg      240

tgctttgatg gagaaaggaa caaccaggtg ttggaggaaa acatggacgt ggagatctgg      300

acaaaggagg gagaaagaaa gaaattacga ccccgctggt tggacgccag aacatactct      360

gatccactgg ccctgcgcga gttcaaagag ttcgcagcag ga                         402


<210>  8
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised nucleotide sequence of the polynucleotide encoding the 
       second region of NS3 of DENV1

<400>  8
gaggatcatg cacactggac tgaagccaag atgctgctgg acaacattaa tactcctgag       60

ggaatcattc cagctctgtt cgagcccgaa agagagaagt ctgcagccat cgacggcgag      120

tatagactga ggggagaggc ccggaagacc ttcgtggaac tgatgaggcg cggcgatctg      180

cccgtgtggc tgagttacaa ggtcgcttca gagggattcc agtatagtga ccgacggtgg      240

tgctttgatg gcgaacgcaa caatcaggtg ctggaggaga acatggatgt cgagatttgg      300

acaaaggaag gcgagcggaa gaaactgcgc ccacgatggc tggacgctcg gacttacagc      360

gatcccctgg cactgagaga attcaaagag tttgctgcag gg                         402


<210>  9
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the second region of NS3 of DENV1

<400>  9

Glu Asp His Ala His Trp Thr Glu Ala Lys Met Leu Leu Asp Asn Ile 
1               5                   10                  15      


Asn Thr Pro Glu Gly Ile Ile Pro Ala Leu Phe Glu Pro Glu Arg Glu 
            20                  25                  30          


Lys Ser Ala Ala Ile Asp Gly Glu Tyr Arg Leu Arg Gly Glu Ala Arg 
        35                  40                  45              


Lys Thr Phe Val Glu Leu Met Arg Arg Gly Asp Leu Pro Val Trp Leu 
    50                  55                  60                  


Ser Tyr Lys Val Ala Ser Glu Gly Phe Gln Tyr Ser Asp Arg Arg Trp 
65                  70                  75                  80  


Cys Phe Asp Gly Glu Arg Asn Asn Gln Val Leu Glu Glu Asn Met Asp 
                85                  90                  95      


Val Glu Ile Trp Thr Lys Glu Gly Glu Arg Lys Lys Leu Arg Pro Arg 
            100                 105                 110         


Trp Leu Asp Ala Arg Thr Tyr Ser Asp Pro Leu Ala Leu Arg Glu Phe 
        115                 120                 125             


Lys Glu Phe Ala Ala Gly 
    130                 


<210>  10
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the 
       NS4b fragment of DENV1

<400>  10
gtggctgttg aaaatcacca ccatgccgca atgctggacg tagacttaca tccagcttca       60

gcctggaccc tctatgcagt ggccacaaca attatcactc ccatgatgag gcacacaata      120

gaaaacacaa cggcaaacat ttccctgaca gccattgcaa accaggcggc tatattgatg      180

ggacttgaca aaggatggcc aatatcgaag atggacatag gagttccact tctcgccttg      240

gggtgctatt cccaggtg                                                    258


<210>  11
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised nucleotide sequence of the polynucleotide encoding the 
       NS4b fragment of DENV1

<400>  11
gtggccgtcg agaatcacca tcacgccgct atgctggacg tggatctgca tcctgccagt       60

gcttggaccc tgtatgcagt ggccactacc atcattaccc caatgatgcg ccacacaatc      120

gagaacacaa ctgccaatat ctcactgaca gctattgcaa accaggcagc cattctgatg      180

ggactggaca aaggctggcc catcagcaag atggatattg gcgtgcctct gctggccctg      240

gggtgttaca gtcaggtg                                                    258


<210>  12
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the NS4b fragment of DENV1

<400>  12

Val Ala Val Glu Asn His His His Ala Ala Met Leu Asp Val Asp Leu 
1               5                   10                  15      


His Pro Ala Ser Ala Trp Thr Leu Tyr Ala Val Ala Thr Thr Ile Ile 
            20                  25                  30          


Thr Pro Met Met Arg His Thr Ile Glu Asn Thr Thr Ala Asn Ile Ser 
        35                  40                  45              


Leu Thr Ala Ile Ala Asn Gln Ala Ala Ile Leu Met Gly Leu Asp Lys 
    50                  55                  60                  


Gly Trp Pro Ile Ser Lys Met Asp Ile Gly Val Pro Leu Leu Ala Leu 
65                  70                  75                  80  


Gly Cys Tyr Ser Gln Val 
                85      


<210>  13
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native nucleotide sequence of the polynucleotide encoding the NS5
       fragment of DENV1

<400>  13
ctggatatca ttggccagag gatagagaac ataaaacatg aacataagtc aacatggcat       60

tatgatgagg acaatccata taaaacatgg gcctatcacg gatcatatga ggtcaagcca      120

tcaggatcag cctcatccat ggtcaatggc gtggtgaaac tgctcaccaa accatgggat      180

gtcatcccca tggtcacaca aatagccatg actgacacca caccctttgg acaacagagg      240

gtgttcaaag agaaagttga cacgcgcaca ccaaaagcaa aacgaggcac agcacaaatc      300

atggaggtga cagccaaatg gttatggggt tttctttcta gaaacaaaaa accaagaatt      360

tgtacaagag aggagttcac aagaaaagtc aggtcaaacg ca                         402


<210>  14
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised nucleotide sequence of the polynucleotide encoding the 
       NS5 fragment of DENV1

<400>  14
ctggacatca ttggccagag gatcgagaac attaagcatg agcacaaatc aacctggcat       60

tacgacgaag ataatcccta taagacatgg gcctaccacg gaagctatga ggtgaaacct      120

tcaggcagcg ccagcagcat ggtcaacggg gtggtcaagc tgctgaccaa accttgggac      180

gtgatcccaa tggtcactca gattgccatg accgatacca ccccattcgg ccagcagcgg      240

gtgttcaagg agaaggtgga cacccgcaca cctaaggcta aacgagggac tgcacagatc      300

atggaggtga ccgccaagtg gctgtgggga ttcctgtcca ggaacaagaa gccaagaatc      360

tgtaccaggg aagagttcac aagaaaggtc cggtcaaacg cc                         402


<210>  15
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the NS5 fragment of DENV1

<400>  15

Leu Asp Ile Ile Gly Gln Arg Ile Glu Asn Ile Lys His Glu His Lys 
1               5                   10                  15      


Ser Thr Trp His Tyr Asp Glu Asp Asn Pro Tyr Lys Thr Trp Ala Tyr 
            20                  25                  30          


His Gly Ser Tyr Glu Val Lys Pro Ser Gly Ser Ala Ser Ser Met Val 
        35                  40                  45              


Asn Gly Val Val Lys Leu Leu Thr Lys Pro Trp Asp Val Ile Pro Met 
    50                  55                  60                  


Val Thr Gln Ile Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg 
65                  70                  75                  80  


Val Phe Lys Glu Lys Val Asp Thr Arg Thr Pro Lys Ala Lys Arg Gly 
                85                  90                  95      


Thr Ala Gln Ile Met Glu Val Thr Ala Lys Trp Leu Trp Gly Phe Leu 
            100                 105                 110         


Ser Arg Asn Lys Lys Pro Arg Ile Cys Thr Arg Glu Glu Phe Thr Arg 
        115                 120                 125             


Lys Val Arg Ser Asn Ala 
    130                 


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P20 epitope

<400>  16

Leu Pro Glu Ile Glu Asp Glu Val Phe 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P19 epitope

<400>  17

His Pro Gly Ser Gly Lys Thr Arg Arg Tyr 
1               5                   10  


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P30 epitope

<400>  18

Arg Tyr Leu Pro Ala Ile Val Arg Glu Ala Ile 
1               5                   10      


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P451 epitope

<400>  19

Tyr Leu Pro Ala Ile Val Arg Glu Ala 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P11 epitope

<400>  20

Leu Pro Ala Ile Val Arg Glu Ala Ile 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P36 epitope

<400>  21

Ala Pro Thr Arg Val Val Ala Ser Glu Met 
1               5                   10  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P48 EPITOPE

<400>  22

Glu Met Ala Glu Ala Leu Lys Gly Met Pro Ile Arg Tyr Gln Thr 
1               5                   10                  15  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P12 epitope

<400>  23

Ser Pro Val Arg Val Pro Asn Tyr Asn Met 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P454 epitope

<400>  24

Val Pro Asn Tyr Asn Met Ile Ile Met 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P18 epitope

<400>  25

Asp Pro Ser Ser Ile Ala Ala Arg Gly Tyr 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P457 epitope

<400>  26

Ala Val Ile Gln Asp Glu Glu Arg Asp Ile 
1               5                   10  


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P453 epitope

<400>  27

Arg Ser Trp Asn Ser Gly Tyr Glu Trp 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P49 epitope

<400>  28

Thr Pro Glu Gly Ile Ile Pro Ala Leu 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P28 epitope

<400>  29

Lys Thr Phe Val Glu Leu Met Arg Arg 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P2 epitope

<400>  30

Glu Leu Met Arg Arg Gly Asp Leu Pro Val 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P450 epitope

<400>  31

Asp Leu Met Arg Arg Gly Asp Leu Pro Val 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P50 epitope

<400>  32

Leu Pro Val Trp Leu Ser Tyr Lys Val Ala 
1               5                   10  


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P32 epitope

<400>  33

Gln Tyr Ser Asp Arg Arg Trp Cys Phe 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P73 epitope

<400>  34

Asn Tyr Ala Asp Arg Arg Trp Cys Phe 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P74 epitope

<400>  35

Asn Tyr Ala Asp Arg Lys Trp Cys Phe 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P75 epitope

<400>  36

Lys Tyr Thr Asp Arg Lys Trp Cys Phe 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P76 epitope

<400>  37

Ser Tyr Lys Asp Arg Glu Trp Cys Phe 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P35 epitope

<400>  38

Arg Pro Arg Trp Leu Asp Ala Arg Thr 
1               5                   


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P17 epitope

<400>  39

Leu Asp Ala Arg Thr Tyr Ser Asp Pro Leu Ala Leu Arg Glu Phe Lys 
1               5                   10                  15      


Glu Phe 
        


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P29 epitope

<400>  40

Arg Ile Tyr Ser Asp Pro Leu Ala Leu Lys 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P452 epitope

<400>  41

Arg Thr Tyr Ser Asp Pro Leu Ala Leu Arg 
1               5                   10  


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P21 epitope

<400>  42

His Pro Ala Ser Ala Trp Thr Leu Tyr 
1               5                   


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P16 epitope

<400>  43

Pro Ala Ser Ala Trp Thr Leu Tyr 
1               5               


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P13 epitope

<400>  44

His Pro Ala Ser Ala Trp Thr Leu Tyr Ala 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P51 epitope

<400>  45

Thr Leu Tyr Ala Val Ala Thr Thr Ile 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P52 epitope

<400>  46

Val Ala Thr Thr Ile Ile Thr Pro Met 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P33 epitope

<400>  47

Ile Thr Pro Met Met Arg His Thr Ile 
1               5                   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P14 epitope

<400>  48

Thr Pro Met Met Arg His Thr Ile Glu Asn 
1               5                   10  


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P22 epitope

<400>  49

Ile Ala Asn Gln Ala Ala Ile Leu Met 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P456 epitope

<400>  50

Ala Ala Ile Leu Met Gly Leu Asp Lys 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P53 epitope

<400>  51

Lys Met Asp Ile Gly Val Pro Leu Leu 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P54 epitope

<400>  52

Val Pro Leu Leu Ala Leu Gly Cys Tyr 
1               5                   


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P55 epitope

<400>  53

Asp Asn Pro Tyr Lys Thr Trp Ala Tyr His 
1               5                   10  


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P24 epitope

<400>  54

Trp Ala Tyr His Gly Ser Tyr Glu Val 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P56 epitope

<400>  55

Ser Met Val Asn Gly Val Val Lys Leu 
1               5                   


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P5 epitope

<400>  56

Leu Leu Thr Lys Pro Trp Asp Val Ile Pro Met Val Thr Gln Ile 
1               5                   10                  15  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P6 epitope

<400>  57

Leu Leu Thr Lys Pro Trp Asp Val Ile Pro 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P7 epitope

<400>  58

Leu Thr Lys Pro Trp Asp Val Ile Pro Met 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P8 epitope

<400>  59

Thr Lys Pro Trp Asp Val Ile Pro Met Val 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P9 epitope

<400>  60

Lys Pro Trp Asp Val Ile Pro Met Val Thr 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P10 epitope

<400>  61

Pro Trp Asp Val Ile Pro Met Val Thr Gln 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P27 epitope

<400>  62

Trp Asp Val Ile Pro Met Val Thr Gln Ile 
1               5                   10  


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P455 epitope

<400>  63

Ile Pro Met Val Thr Gln Ile Ala Met 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P34 epitope

<400>  64

Asp Thr Thr Pro Phe Gly Gln Gln Arg 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P23 epitope

<400>  65

Thr Pro Phe Gly Gln Gln Arg Val Phe 
1               5                   


<210>  66
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P3 epitope

<400>  66

Thr Ala Lys Trp Leu Trp Gly Phe Leu Ser Arg Asn Lys Lys Pro Arg 
1               5                   10                  15      


Ile Cys Thr Arg 
            20  


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P4 epitope

<400>  67

Trp Gly Phe Leu Ser Arg Asn Lys Lys 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the P15 epitope

<400>  68

Lys Pro Arg Ile Cys Thr Arg Glu Glu Phe 
1               5                   10  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 8-22 of the first 
       region of NS3

<400>  69

Pro Glu Leu Glu Glu Glu Met Phe Lys Lys Arg Asn Leu Thr Ile 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 18-32 of the first
       region of NS3

<400>  70

Arg Lys Leu Thr Ile Met Asp Leu His Pro Gly Ser Gly Lys Thr 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 32-46 of the first
       region of NS3

<400>  71

Thr Lys Arg Tyr Leu Pro Ala Ile Val Arg Glu Ala Ile Lys Arg 
1               5                   10                  15  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 33-42 of the first
       region of NS3

<400>  72

Arg Lys Tyr Leu Pro Ala Ile Val Arg Glu 
1               5                   10  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 36-50 of the first
       region of NS3

<400>  73

Leu Pro Ala Ile Val Arg Glu Ala Ile Lys Arg Arg Leu Arg Thr 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 40-54 of the first
       region of NS3

<400>  74

Val Arg Glu Ala Ile Lys Arg Arg Leu Arg Thr Leu Ile Leu Ala 
1               5                   10                  15  


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 56-66 of the first
       region of NS3

<400>  75

Thr Arg Val Val Ala Ala Glu Met Glu Glu Ala 
1               5                   10      


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 55-69 of the first
       region of NS3

<400>  76

Pro Thr Arg Val Val Ala Ala Glu Met Glu Glu Ala Met Lys Gly 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 66-80 of the first
       region of NS3

<400>  77

Ala Leu Lys Gly Met Pro Ile Arg Tyr Gln Thr Thr Ala Val Lys 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 68-82 of the first
       region of NS3

<400>  78

Lys Gly Leu Pro Ile Arg Tyr Gln Thr Thr Ala Thr Lys Ser Glu 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 72-86 of the first
       region of NS3

<400>  79

Ile Arg Tyr Gln Thr Thr Ala Thr Lys Ser Glu His Thr Gly Arg 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 83-97 of the first
       region of NS3

<400>  80

His Thr Gly Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Glu 
1               5                   10                  15  


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 86-97 of the first
       region of NS3

<400>  81

Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Phe 
1               5                   10          


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 87-96 of the first
       region of NS3

<400>  82

Glu Ile Val Asp Leu Met Cys His Ala Thr 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 89-98 of the first
       region of NS3

<400>  83

Val Asp Leu Met Cys His Ala Thr Phe Thr 
1               5                   10  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 96-110 of the 
       first region of NS3

<400>  84

Thr Phe Thr Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn Tyr 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 108-122 of the 
       first region of NS3

<400>  85

Pro Asn Tyr Asn Leu Ile Ile Met Asp Glu Ala His Phe Thr Asp 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 124-138 of the 
       first region of NS3

<400>  86

Ala Ser Ile Ala Ala Arg Gly Tyr Ile Ser Thr Arg Val Gly Met 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 139-154 of the 
       first region of NS3

<400>  87

Glu Ala Ala Ala Ile Phe Met Thr Ala Thr Pro Pro Gly Thr Ala 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 287-301 of the 
       second region of NS3

<400>  88

Arg Glu Gly Glu Lys Lys Lys Leu Arg Pro Arg Trp Leu Asp Arg 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 307-319 of the 
       second region of NS3

<400>  89

Pro Leu Ala Leu Lys Glu Phe Lys Asp Phe Ala Ala Gly Arg Lys 
1               5                   10                  15  


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 417-433 of NS5

<400>  90

Lys Glu Glu His Ser Ser Thr Trp His Tyr Asp Asp Glu Asn Pro Tyr 
1               5                   10                  15      


Lys 
    


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 423-439 of NS5

<400>  91

Thr Trp His Tyr Asp Asp Glu Asn Pro Tyr Lys Thr Trp Ala Tyr His 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 427-444 of NS5

<400>  92

Asp Glu Asn Pro Tyr Lys Thr Trp Ala Tyr His Gly Ser Tyr Glu Val 
1               5                   10                  15      


Lys 
    


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 433-447 of NS5

<400>  93

Lys Thr Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln Thr Gly 
1               5                   10                  15  


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 451-473 of NS5

<400>  94

Ser Met Ile Asn Gly Val Val Lys Leu Leu Thr Lys Pro Trp Asp Val 
1               5                   10                  15      


Val 
    


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 462-471 of NS5

<400>  95

Lys Pro Trp Asp Val Leu Pro Met Val 
1               5                   


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 457-463 of NS5

<400>  96

Val Lys Leu Leu Thr Lys Pro Trp Asp Val Val Pro Met Val Thr Gln 
1               5                   10                  15      


Met 
    


<210>  97
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the peptide at position 469-485 of NS5

<400>  97

Met Val Thr Gln Met Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln 
1               5                   10                  15      


Arg Val 
        


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  98

Val Lys Ser Glu His Thr Gly Lys Glu Ile Val Asp Leu Met Cys 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  99

His Thr Gly Lys Glu Ile Val Asp Leu Met Cys His Ala Thr Phe 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  100

Glu Ile Val Asp Leu Met Cys His Ala Thr Phe Thr Met Arg Leu 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  101

Leu Met Cys His Ala Thr Phe Thr Met Arg Leu Leu Ser Pro Val 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  102

Ala Thr Phe Thr Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  103

Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn Met Ile 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  104

Glu Phe Lys Glu Phe Ala Ala Gly Val Ala Val Glu Asn His His 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  105

Phe Ala Ala Gly Val Ala Val Glu Asn His His His Ala Ala Met 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  106

Val Ala Val Glu Asn His His His Ala Ala Met Leu Asp Val Asp 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  107

Asn His His His Ala Ala Met Leu Asp Val Asp Leu His Pro Ala 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  108

Ala Ala Met Leu Asp Val Asp Leu His Pro Ala Ser Ala Trp Thr 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  109

Asp Val Asp Leu His Pro Ala Ser Ala Trp Thr Leu Tyr Ala Val 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  110

His Pro Ala Ser Ala Trp Thr Leu Tyr Ala Val Ala Thr Thr Ile 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  111

Ala Trp Thr Leu Tyr Ala Val Ala Thr Thr Ile Ile Thr Pro Met 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  112

Tyr Ala Val Ala Thr Thr Ile Ile Thr Pro Met Met Arg His Thr 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  113

Thr Thr Ile Ile Thr Pro Met Met Arg His Thr Ile Glu Asn Thr 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  114

Thr Pro Met Met Arg His Thr Ile Glu Asn Thr Thr Ala Asn Ile 
1               5                   10                  15  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  115

Arg His Thr Ile Glu Asn Thr Thr Ala Asn Ile Ser Leu Thr Ala 
1               5                   10                  15  


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  116

Glu Asn Thr Thr Ala Asn Ile Ser Leu Thr Ala Ile Ala Asn Gln 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  117

Ala Asn Ile Ser Leu Thr Ala Ile Ala Asn Gln Ala Ala Ile Leu 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  118

Gly Trp Pro Ile Ser Lys Met Asp Ile Gly Val Pro Leu Leu Ala 
1               5                   10                  15  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  119

Ser Lys Met Asp Ile Gly Val Pro Leu Leu Ala Leu Gly Cys Tyr 
1               5                   10                  15  


<210>  120
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  120

Ile Gly Val Pro Leu Leu Ala Leu Gly Cys Tyr Ser Gln Val Leu 
1               5                   10                  15  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  121

Asp Glu Asp Asn Pro Tyr Lys Thr Trp Ala Tyr His Gly Ser Tyr 
1               5                   10                  15  


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  122

Pro Tyr Lys Thr Trp Ala Tyr His Gly Ser Tyr Glu Val Lys Pro 
1               5                   10                  15  


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  123

Trp Ala Tyr His Gly Ser Tyr Glu Val Lys Pro Ser Gly Ser Ala 
1               5                   10                  15  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  124

Gly Ser Tyr Glu Val Lys Pro Ser Gly Ser Ala Ser Ser Met Val 
1               5                   10                  15  


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  125

Val Lys Pro Ser Gly Ser Ala Ser Ser Met Val Asn Gly Val Val 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  126

Gly Ser Ala Ser Ser Met Val Asn Gly Val Val Lys Leu Leu Thr 
1               5                   10                  15  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  127

Ser Met Val Asn Gly Val Val Lys Leu Leu Thr Lys Pro Trp Asp 
1               5                   10                  15  


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  128

Gly Val Val Lys Leu Leu Thr Lys Pro Trp Asp Val Ile Pro Met 
1               5                   10                  15  


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  129

Leu Leu Thr Lys Pro Trp Asp Val Ile Pro Met Val Thr Gln Ile 
1               5                   10                  15  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  130

Pro Trp Asp Val Ile Pro Met Val Thr Gln Ile Ala Met Thr Asp 
1               5                   10                  15  


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  131

Ile Pro Met Val Thr Gln Ile Ala Met Thr Asp Thr Thr Pro Phe 
1               5                   10                  15  


<210>  132
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  132

Thr Gln Ile Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg 
1               5                   10                  15  


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  133

Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg Val Phe Lys Glu 
1               5                   10                  15  


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  134

Phe Thr Met Arg Leu Leu Ser Pro Val 
1               5                   


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  135

Val Ala Val Glu Asn His His His Ala Ala Met 
1               5                   10      


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  136

Leu Tyr Ala Val Ala Thr Thr Ile Ile 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  137

Thr Ala Ile Ala Asn Gln Ala Ala Ile 
1               5                   


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  138

Ser Ser Met Val Asn Gly Val Val Lys Leu 
1               5                   10  


<210>  139
<211>  22363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete optimised nucleotide sequence of the polynucleotide 
       encoding pTM-MVDVax6


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  NotI

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammerhead ribozyme

<220>
<221>  misc_feature
<222>  (83)..(189)
<223>  MV Leader and N promoter

<220>
<221>  misc_feature
<222>  (190)..(1767)
<223>  MV N ORF

<220>
<221>  misc_feature
<222>  (1768)..(1888)
<223>  MV N-P intergenic

<220>
<221>  misc_feature
<222>  (1889)..(3412)
<223>  MV P ORF

<220>
<221>  misc_feature
<222>  (3413)..(3531)
<223>  MV ATU2

<220>
<221>  misc_feature
<222>  (3532)..(5085)
<223>  DENV tetra EDIII + ectoM

<220>
<221>  misc_feature
<222>  (5086)..(5181)
<223>  MV P-M intergenic

<220>
<221>  misc_feature
<222>  (5182)..(6189)
<223>  MV M ORF

<220>
<221>  misc_feature
<222>  (6190)..(7192)
<223>  MV M-F intergenic

<220>
<221>  misc_feature
<222>  (7193)..(8854)
<223>  MV F ORF

<220>
<221>  misc_feature
<222>  (8855)..(9014)
<223>  MV-F-H intergenic

<220>
<221>  misc_feature
<222>  (9015)..(10868)
<223>  MV H ORF

<220>
<221>  misc_feature
<222>  (10869)..(10995)
<223>  MV ATU3

<220>
<221>  misc_feature
<222>  (10996)..(12618)
<223>  DENV1 NS polyepitope

<220>
<221>  misc_feature
<222>  (12619)..(12712)
<223>  MV H-L intergenic

<220>
<221>  misc_feature
<222>  (12713)..(19263)
<223>  MV L ORF

<220>
<221>  misc_feature
<222>  (19264)..(19372)
<223>  MV Trailer

<220>
<221>  misc_feature
<222>  (19373)..(19456)
<223>  HDV ribozyme

<220>
<221>  misc_feature
<222>  (19457)..(19598)
<223>  T7 terminator

<220>
<221>  misc_feature
<222>  (19599)..(19606)
<223>  Not I

<220>
<221>  misc_feature
<222>  (19607)..(22363)
<223>  pTM plasmid

<400>  139
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagc ctaccctcca tcattgttat     3480

aaaaaactta ggaaccaggt ccacacagcc gccagcccat caacgcgtac gatgggcatc     3540

atattcattc ttcttatgct ggttacaccg tctatggcgg agaaacttcg aatcaaaggt     3600

atgagctata cgatgtgcag cggcaagttc aagatcgaga aggaaatggc tgaaacccag     3660

cacggtacaa ctgtggtcaa agtcaaatat gagggggctg gcgctccctg taaagtaccc     3720

attgagatta gggacgtcaa taaagagaag gtggtaggtc gcatcatctc cagtacacct     3780

ttggccgaga acacgaactc cgtcacaaac atagagttgg aacccccgtt cggagactca     3840

tacattgtga tcggggtggg caactctgca ctcacactgc attggttcaa gaagggaagc     3900

agtatcggcc gcagggataa gagagacaaa ctgaaattga aaggtatgtc ctatgccatg     3960

tgcacgaata ctttcgttct caagaaagaa gtatctgaga ctcagcacgg aaccatcctg     4020

atcaaagtcg agtacaaagg agaagacgtg ccctgtaaga tcccattcag taccgaggat     4080

ggacagggca aggcccataa cggcaggctg ataaccgcca accctgtggt tacaaagaag     4140

gaagagccag tcaatatcga agctgagcca ccgttcgggg agagcaacat agtaattggc     4200

ataggggata atgctttgaa gatcaactgg tacaagaaag gaagctccat tggccgaaga     4260

gataagcgcg acaaactcca gctgaaagga atgagctact ccatgtgtac tgggaagttc     4320

aagattgtca aggaaatcgc cgaaactcag catggcacta ttgtgatccg cgtgcagtat     4380

gaaggcgatg gtagcccctg caagatacca tttgaaatca ccgatttgga gaaacggcac     4440

gtcctgggtc ggctcattac cgtgaaccca atcgtgaccg agaaggacag tccagttaat     4500

atcgaggccg agcctccttt cggcgacagt tacatcattg taggggtgga accagggcaa     4560

ctgaagctga actggttcaa gaaaggcagc agtataggac ggcgggataa acgggacaaa     4620

ctcacactga aaggcatgtc atacgttatg tgcaccggct cattcaaact ggagaaggaa     4680

gttgcagaga cacagcatgg gaccgtgctc gtgcaggtca aatacgaggg caccgacgct     4740

ccttgcaaga ttccgttcag tacacaggac gagaaaggcg tgactcagaa cggcagattg     4800

attacagcga accctatcgt gactgacaag gagaagccag ttaacatcga gactgagccg     4860

cctttcggag aatcatacat tatcgtggga gccggcgaga aggcactgaa actcagctgg     4920

ttcaagaagg gcagctcaat cggtcggaga gacaagcggt ctgtcgccct cgcaccgcac     4980

gtgggcctgg gtctggaaac gaggaccgag acgtggatga gttccgaagg cgcatggaag     5040

caaatccaga aagtggagac gtgggccctc aggcatccgt aatgagcgcg cagcgcttag     5100

acgtctcgcg atcgatacta gtacaaccta aatccattat aaaaaactta ggagcaaagt     5160

gattgcctcc caaggtccac aatgacagag acctacgact tcgacaagtc ggcatgggac     5220

atcaaagggt cgatcgctcc gatacaaccc accacctaca gtgatggcag gctggtgccc     5280

caggtcagag tcatagatcc tggtctaggc gacaggaagg atgaatgctt tatgtacatg     5340

tttctgctgg gggttgttga ggacagcgat tccctagggc ctccaatcgg gcgagcattt     5400

gggttcctgc ccttaggtgt tggcagatcc acagcaaagc ccgaaaaact cctcaaagag     5460

gccactgagc ttgacatagt tgttagacgt acagcagggc tcaatgaaaa actggtgttc     5520

tacaacaaca ccccactaac tctcctcaca ccttggagaa aggtcctaac aacagggagt     5580

gtcttcaacg caaaccaagt gtgcaatgcg gttaatctga taccgctcga taccccgcag     5640

aggttccgtg ttgtttatat gagcatcacc cgtctttcgg ataacgggta ttacaccgtt     5700

cctagaagaa tgctggaatt cagatcggtc aatgcagtgg ccttcaacct gctggtgacc     5760

cttaggattg acaaggcgat aggccctggg aagatcatcg acaatacaga gcaacttcct     5820

gaggcaacat ttatggtcca catcgggaac ttcaggagaa agaagagtga agtctactct     5880

gccgattatt gcaaaatgaa aatcgaaaag atgggcctgg tttttgcact tggtgggata     5940

gggggcacca gtcttcacat tagaagcaca ggcaaaatga gcaagactct ccatgcacaa     6000

ctcgggttca agaagacctt atgttacccg ctgatggata tcaatgaaga ccttaatcga     6060

ttactctgga ggagcagatg caagatagta agaatccagg cagttttgca gccatcagtt     6120

cctcaagaat tccgcattta cgacgacgtg atcataaatg atgaccaagg actattcaaa     6180

gttctgtaga ccgtagtgcc cagcaatgcc cgaaaacgac ccccctcaca atgacagcca     6240

gaaggcccgg acaaaaaagc cccctccgaa agactccacg gaccaagcga gaggccagcc     6300

agcagccgac ggcaagcgcg aacaccaggc ggccccagca cagaacagcc ctgacacaag     6360

gccaccacca gccaccccaa tctgcatcct cctcgtggga cccccgagga ccaaccccca     6420

aggctgcccc cgatccaaac caccaaccgc atccccacca cccccgggaa agaaaccccc     6480

agcaattgga aggcccctcc ccctcttcct caacacaaga actccacaac cgaaccgcac     6540

aagcgaccga ggtgacccaa ccgcaggcat ccgactccct agacagatcc tctctccccg     6600

gcaaactaaa caaaacttag ggccaaggaa catacacacc caacagaacc cagaccccgg     6660

cccacggcgc cgcgccccca acccccgaca accagaggga gcccccaacc aatcccgccg     6720

gctcccccgg tgcccacagg cagggacacc aacccccgaa cagacccagc acccaaccat     6780

cgacaatcca agacgggggg gcccccccaa aaaaaggccc ccaggggccg acagccagca     6840

ccgcgaggaa gcccacccac cccacacacg accacggcaa ccaaaccaga acccagacca     6900

ccctgggcca ccagctccca gactcggcca tcaccccgca gaaaggaaag gccacaaccc     6960

gcgcacccca gccccgatcc ggcggggagc cacccaaccc gaaccagcac ccaagagcga     7020

tccccgaagg acccccgaac cgcaaaggac atcagtatcc cacagcctct ccaagtcccc     7080

cggtctcctc ctcttctcga agggaccaaa agatcaatcc accacacccg acgacactca     7140

actccccacc cctaaaggag acaccgggaa tcccagaatc aagactcatc caatgtccat     7200

catgggtctc aaggtgaacg tctctgccat attcatggca gtactgttaa ctctccaaac     7260

acccaccggt caaatccatt ggggcaatct ctctaagata ggggtggtag gaataggaag     7320

tgcaagctac aaagttatga ctcgttccag ccatcaatca ttagtcataa aattaatgcc     7380

caatataact ctcctcaata actgcacgag ggtagagatt gcagaataca ggagactact     7440

gagaacagtt ttggaaccaa ttagagatgc acttaatgca atgacccaga atataagacc     7500

ggttcagagt gtagcttcaa gtaggagaca caagagattt gcgggagtag tcctggcagg     7560

tgcggcccta ggcgttgcca cagctgctca gataacagcc ggcattgcac ttcaccagtc     7620

catgctgaac tctcaagcca tcgacaatct gagagcgagc ctggaaacta ctaatcaggc     7680

aattgagaca atcagacaag cagggcagga gatgatattg gctgttcagg gtgtccaaga     7740

ctacatcaat aatgagctga taccgtctat gaaccaacta tcttgtgatt taatcggcca     7800

gaagctcggg ctcaaattgc tcagatacta tacagaaatc ctgtcattat ttggccccag     7860

tttacgggac cccatatctg cggagatatc tatccaggct ttgagctatg cgcttggagg     7920

agacatcaat aaggtgttag aaaagctcgg atacagtgga ggtgatttac tgggcatctt     7980

agagagcgga ggaataaagg cccggataac tcacgtcgac acagagtcct acttcattgt     8040

cctcagtata gcctatccga cgctgtccga gattaagggg gtgattgtcc accggctaga     8100

gggggtctcg tacaacatag gctctcaaga gtggtatacc actgtgccca agtatgttgc     8160

aacccaaggg taccttatct cgaattttga tgagtcatcg tgtactttca tgccagaggg     8220

gactgtgtgc agccaaaatg ccttgtaccc gatgagtcct ctgctccaag aatgcctccg     8280

ggggtacacc aagtcctgtg ctcgtacact cgtatccggg tcttttggga accggttcat     8340

tttatcacaa gggaacctaa tagccaattg tgcatcaatc ctttgcaagt gttacacaac     8400

aggaacgatc attaatcaag accctgacaa gatcctaaca tacattgctg ccgatcactg     8460

cccggtagtc gaggtgaacg gcgtgaccat ccaagtcggg agcaggaggt atccagacgc     8520

tgtgtacttg cacagaattg acctcggtcc tcccatatca ttggagaggt tggacgtagg     8580

gacaaatctg gggaatgcaa ttgctaagtt ggaggatgcc aaggaattgt tggagtcatc     8640

ggaccagata ttgaggagta tgaaaggttt atcgagcact agcatagtct acatcctgat     8700

tgcagtgtgt cttggagggt tgatagggat ccccgcttta atatgttgct gcagggggcg     8760

ttgtaacaaa aagggagaac aagttggtat gtcaagacca ggcctaaagc ctgatcttac     8820

gggaacatca aaatcctatg taaggtcgct ctgatcctct acaactcttg aaacacaaat     8880

gtcccacaag tctcctcttc gtcatcaagc aaccaccgca cccagcatca agcccacctg     8940

aaattatctc cggcttccct ctggccgaac aatatcggta gttaatcaaa acttagggtg     9000

caagatcatc cacaatgtca ccacaacgag accggataaa tgccttctac aaagataacc     9060

cccatcccaa gggaagtagg atagtcatta acagagaaca tcttatgatt gatagacctt     9120

atgttttgct ggctgttctg tttgtcatgt ttctgagctt gatcgggttg ctagccattg     9180

caggcattag acttcatcgg gcagccatct acaccgcaga gatccataaa agcctcagca     9240

ccaatctaga tgtaactaac tcaatcgagc atcaggtcaa ggacgtgctg acaccactct     9300

tcaaaatcat cggtgatgaa gtgggcctga ggacacctca gagattcact gacctagtga     9360

aattaatctc tgacaagatt aaattcctta atccggatag ggagtacgac ttcagagatc     9420

tcacttggtg tatcaacccg ccagagagaa tcaaattgga ttatgatcaa tactgtgcag     9480

atgtggctgc tgaagagctc atgaatgcat tggtgaactc aactctactg gagaccagaa     9540

caaccaatca gttcctagct gtctcaaagg gaaactgctc agggcccact acaatcagag     9600

gtcaattctc aaacatgtcg ctgtccctgt tagacttgta tttaggtcga ggttacaatg     9660

tgtcatctat agtcactatg acatcccagg gaatgtatgg gggaacttac ctagtggaaa     9720

agcctaatct gagcagcaaa aggtcagagt tgtcacaact gagcatgtac cgagtgtttg     9780

aagtaggtgt tatcagaaat ccgggtttgg gggctccggt gttccatatg acaaactatc     9840

ttgagcaacc agtcagtaat gatctcagca actgtatggt ggctttgggg gagctcaaac     9900

tcgcagccct ttgtcacggg gaagattcta tcacaattcc ctatcaggga tcagggaaag     9960

gtgtcagctt ccagctcgtc aagctaggtg tctggaaatc cccaaccgac atgcaatcct    10020

gggtcccctt atcaacggat gatccagtga tagacaggct ttacctctca tctcacagag    10080

gtgttatcgc tgacaatcaa gcaaaatggg ctgtcccgac aacacgaaca gatgacaagt    10140

tgcgaatgga gacatgcttc caacaggcgt gtaagggtaa aatccaagca ctctgcgaga    10200

atcccgagtg ggcaccattg aaggataaca ggattccttc atacggggtc ttgtctgttg    10260

atctgagtct gacagttgag cttaaaatca aaattgcttc gggattcggg ccattgatca    10320

cacacggttc agggatggac ctatacaaat ccaaccacaa caatgtgtat tggctgacta    10380

tcccgccaat gaagaaccta gccttaggtg taatcaacac attggagtgg ataccgagat    10440

tcaaggttag tccctacctc ttcactgtcc caattaagga agcaggcgaa gactgccatg    10500

ccccaacata cctacctgcg gaggtggatg gtgatgtcaa actcagttcc aatctggtga    10560

ttctacctgg tcaagatctc caatatgttt tggcaaccta cgatacttcc agggttgaac    10620

atgctgtggt ttattacgtt tacagcccaa gccgctcatt ttcttacttt tatcctttta    10680

ggttgcctat aaagggggtc cccatcgaat tacaagtgga atgcttcaca tgggaccaaa    10740

aactctggtg ccgtcacttc tgtgtgcttg cggactcaga atctggtgga catatcactc    10800

actctgggat ggtgggcatg ggagtcagct gcacagtcac ccgggaagat ggaaccaatc    10860

gcagataggg ctgctagtga accaatcaca tgatgtcacc cagacatcag gcatacccac    10920

tagtctaccc tccatcattg ttataaaaaa cttaggaacc aggtccacac agccgccagc    10980

ccatcaacgc gtacgatggc atcacaggag ggaccactgc ccgaaattga ggacgaagtg    11040

tttagaaagc gaaatctgac tattatggac ctgcaccccg gatctggcaa gacccggaga    11100

tacctgccag ccatcgtgag ggaggctatt aagcggaaac tgagaacact gatcctggcc    11160

ccaactcgcg tggtcgcttc cgaaatggct gaggccctga aaggcatgcc catccggtat    11220

cagaccacag cagtgaagtc tgaacatacc ggcaaggaga ttgtggacct gatgtgccac    11280

gccactttca ccatgcgact gctgagccca gtgcgggtcc ccaactacaa tatgatcatt    11340

atggacgagg cccactttac tgatcccagc tccatcgccg ctagaggata tatttccacc    11400

agggtgggaa tgggcgaggc agcagctatc ttcatgacag caactccccc tggcagcgtg    11460

gaggcatttc ctcagtccaa cgccgtcatc caggacgagg agcgggacat tcctgagcgg    11520

agctggaatt ctgggtacga atggatcaca gacgaggatc atgcacactg gactgaagcc    11580

aagatgctgc tggacaacat taatactcct gagggaatca ttccagctct gttcgagccc    11640

gaaagagaga agtctgcagc catcgacggc gagtatagac tgaggggaga ggcccggaag    11700

accttcgtgg aactgatgag gcgcggcgat ctgcccgtgt ggctgagtta caaggtcgct    11760

tcagagggat tccagtatag tgaccgacgg tggtgctttg atggcgaacg caacaatcag    11820

gtgctggagg agaacatgga tgtcgagatt tggacaaagg aaggcgagcg gaagaaactg    11880

cgcccacgat ggctggacgc tcggacttac agcgatcccc tggcactgag agaattcaaa    11940

gagtttgctg caggggtggc cgtcgagaat caccatcacg ccgctatgct ggacgtggat    12000

ctgcatcctg ccagtgcttg gaccctgtat gcagtggcca ctaccatcat taccccaatg    12060

atgcgccaca caatcgagaa cacaactgcc aatatctcac tgacagctat tgcaaaccag    12120

gcagccattc tgatgggact ggacaaaggc tggcccatca gcaagatgga tattggcgtg    12180

cctctgctgg ccctggggtg ttacagtcag gtgctggaca tcattggcca gaggatcgag    12240

aacattaagc atgagcacaa atcaacctgg cattacgacg aagataatcc ctataagaca    12300

tgggcctacc acggaagcta tgaggtgaaa ccttcaggca gcgccagcag catggtcaac    12360

ggggtggtca agctgctgac caaaccttgg gacgtgatcc caatggtcac tcagattgcc    12420

atgaccgata ccaccccatt cggccagcag cgggtgttca aggagaaggt ggacacccgc    12480

acacctaagg ctaaacgagg gactgcacag atcatggagg tgaccgccaa gtggctgtgg    12540

ggattcctgt ccaggaacaa gaagccaaga atctgtacca gggaagagtt cacaagaaag    12600

gtccggtcaa acgcctaatg agcgcgcagc gcttagacgt ctcgcgatcg atgctagtgt    12660

gaaatagaca tcagaattaa gaaaaacgta gggtccaagt ggttccccgt tatggactcg    12720

ctatctgtca accagatctt ataccctgaa gttcacctag atagcccgat agttaccaat    12780

aagatagtag ccatcctgga gtatgctcga gtccctcacg cttacagcct ggaggaccct    12840

acactgtgtc agaacatcaa gcaccgccta aaaaacggat tttccaacca aatgattata    12900

aacaatgtgg aagttgggaa tgtcatcaag tccaagctta ggagttatcc ggcccactct    12960

catattccat atccaaattg taatcaggat ttatttaaca tagaagacaa agagtcaacg    13020

aggaagatcc gtgaactcct caaaaagggg aattcgctgt actccaaagt cagtgataag    13080

gttttccaat gcttaaggga cactaactca cggcttggcc taggctccga attgagggag    13140

gacatcaagg agaaagttat taacttggga gtttacatgc acagctccca gtggtttgag    13200

ccctttctgt tttggtttac agtcaagact gagatgaggt cagtgattaa atcacaaacc    13260

catacttgcc ataggaggag acacacacct gtattcttca ctggtagttc agttgagttg    13320

ctaatctctc gtgaccttgt tgctataatc agtaaagagt ctcaacatgt atattacctg    13380

acatttgaac tggttttgat gtattgtgat gtcatagagg ggaggttaat gacagagacc    13440

gctatgacta ttgatgctag gtatacagag cttctaggaa gagtcagata catgtggaaa    13500

ctgatagatg gtttcttccc tgcactcggg aatccaactt atcaaattgt agccatgctg    13560

gagcctcttt cacttgctta cctgcagctg agggatataa cagtagaact cagaggtgct    13620

ttccttaacc actgctttac tgaaatacat gatgttcttg accaaaacgg gttttctgat    13680

gaaggtactt atcatgagtt aactgaagct ctagattaca ttttcataac tgatgacata    13740

catctgacag gggagatttt ctcatttttc agaagtttcg gccaccccag acttgaagca    13800

gtaacggctg ctgaaaatgt taggaaatac atgaatcagc ctaaagtcat tgtgtatgag    13860

actctgatga aaggtcatgc catattttgt ggaatcataa tcaacggcta tcgtgacagg    13920

cacggaggca gttggccacc gctgaccctc cccctgcatg ctgcagacac aatccggaat    13980

gctcaagctt caggtgaagg gttaacacat gagcagtgcg ttgataactg gaaatctttt    14040

gctggagtga aatttggctg ctttatgcct cttagcctgg atagtgatct gacaatgtac    14100

ctaaaggaca aggcacttgc tgctctccaa agggaatggg attcagttta cccgaaagag    14160

ttcctgcgtt acgaccctcc caagggaacc gggtcacgga ggcttgtaga tgttttcctt    14220

aatgattcga gctttgaccc atatgatgtg ataatgtatg ttgtaagtgg agcttacctc    14280

catgaccctg agttcaacct gtcttacagc ctgaaagaaa aggagatcaa ggaaacaggt    14340

agactttttg ctaaaatgac ttacaaaatg agggcatgcc aagtgattgc tgaaaatcta    14400

atctcaaacg ggattggcaa atattttaag gacaatggga tggccaagga tgagcacgat    14460

ttgactaagg cactccacac tctagctgtc tcaggagtcc ccaaagatct caaagaaagt    14520

cacagggggg ggccagtctt aaaaacctac tcccgaagcc cagtccacac aagtaccagg    14580

aacgtgagag cagcaaaagg gtttataggg ttccctcaag taattcggca ggaccaagac    14640

actgatcatc cggagaatat ggaagcttac gagacagtca gtgcatttat cacgactgat    14700

ctcaagaagt actgccttaa ttggagatat gagaccatca gcttgtttgc acagaggcta    14760

aatgagattt acggattgcc ctcatttttc cagtggctgc ataagaggct tgagacctct    14820

gtcctgtatg taagtgaccc tcattgcccc cccgaccttg acgcccatat cccgttatat    14880

aaagtcccca atgatcaaat cttcattaag taccctatgg gaggtataga agggtattgt    14940

cagaagctgt ggaccatcag caccattccc tatctatacc tggctgctta tgagagcgga    15000

gtaaggattg cttcgttagt gcaaggggac aatcagacca tagccgtaac aaaaagggta    15060

cccagcacat ggccctacaa ccttaagaaa cgggaagctg ctagagtaac tagagattac    15120

tttgtaattc ttaggcaaag gctacatgat attggccatc acctcaaggc aaatgagaca    15180

attgtttcat cacatttttt tgtctattca aaaggaatat attatgatgg gctacttgtg    15240

tcccaatcac tcaagagcat cgcaagatgt gtattctggt cagagactat agttgatgaa    15300

acaagggcag catgcagtaa tattgctaca acaatggcta aaagcatcga gagaggttat    15360

gaccgttacc ttgcatattc cctgaacgtc ctaaaagtga tacagcaaat tctgatctct    15420

cttggcttca caatcaattc aaccatgacc cgggatgtag tcatacccct cctcacaaac    15480

aacgacctct taataaggat ggcactgttg cccgctccta ttggggggat gaattatctg    15540

aatatgagca ggctgtttgt cagaaacatc ggtgatccag taacatcatc aattgctgat    15600

ctcaagagaa tgattctcgc ctcactaatg cctgaagaga ccctccatca agtaatgaca    15660

caacaaccgg gggactcttc attcctagac tgggctagcg acccttactc agcaaatctt    15720

gtatgtgtcc agagcatcac tagactcctc aagaacataa ctgcaaggtt tgtcctgatc    15780

catagtccaa acccaatgtt aaaaggatta ttccatgatg acagtaaaga agaggacgag    15840

ggactggcgg cattcctcat ggacaggcat attatagtac ctagggcagc tcatgaaatc    15900

ctggatcata gtgtcacagg ggcaagagag tctattgcag gcatgctgga taccacaaaa    15960

ggcttgattc gagccagcat gaggaagggg gggttaacct ctcgagtgat aaccagattg    16020

tccaattatg actatgaaca attcagagca gggatggtgc tattgacagg aagaaagaga    16080

aatgtcctca ttgacaaaga gtcatgttca gtgcagctgg cgagagctct aagaagccat    16140

atgtgggcga ggctagctcg aggacggcct atttacggcc ttgaggtccc tgatgtacta    16200

gaatctatgc gaggccacct tattcggcgt catgagacat gtgtcatctg cgagtgtgga    16260

tcagtcaact acggatggtt ttttgtcccc tcgggttgcc aactggatga tattgacaag    16320

gaaacatcat ccttgagagt cccatatatt ggttctacca ctgatgagag aacagacatg    16380

aagcttgcct tcgtaagagc cccaagtcga tccttgcgat ctgctgttag aatagcaaca    16440

gtgtactcat gggcttacgg tgatgatgat agctcttgga acgaagcctg gttgttggct    16500

aggcaaaggg ccaatgtgag cctggaggag ctaagggtga tcactcccat ctcaacttcg    16560

actaatttag cgcataggtt gagggatcgt agcactcaag tgaaatactc aggtacatcc    16620

cttgtccgag tggcgaggta taccacaatc tccaacgaca atctctcatt tgtcatatca    16680

gataagaagg ttgatactaa ctttatatac caacaaggaa tgcttctagg gttgggtgtt    16740

ttagaaacat tgtttcgact cgagaaagat accggatcat ctaacacggt attacatctt    16800

cacgtcgaaa cagattgttg cgtgatcccg atgatagatc atcccaggat acccagctcc    16860

cgcaagctag agctgagggc agagctatgt accaacccat tgatatatga taatgcacct    16920

ttaattgaca gagatgcaac aaggctatac acccagagcc ataggaggca ccttgtggaa    16980

tttgttacat ggtccacacc ccaactatat cacattttag ctaagtccac agcactatct    17040

atgattgacc tggtaacaaa atttgagaag gaccatatga atgaaatttc agctctcata    17100

ggggatgacg atatcaatag tttcataact gagtttctgc tcatagagcc aagattattc    17160

actatctact tgggccagtg tgcggccatc aattgggcat ttgatgtaca ttatcataga    17220

ccatcaggga aatatcagat gggtgagctg ttgtcatcgt tcctttctag aatgagcaaa    17280

ggagtgttta aggtgcttgt caatgctcta agccacccaa agatctacaa gaaattctgg    17340

cattgtggta ttatagagcc tatccatggt ccttcacttg atgctcaaaa cttgcacaca    17400

actgtgtgca acatggttta cacatgctat atgacctacc tcgacctgtt gttgaatgaa    17460

gagttagaag agttcacatt tctcttgtgt gaaagcgacg aggatgtagt accggacaga    17520

ttcgacaaca tccaggcaaa acacttatgt gttctggcag atttgtactg tcaaccaggg    17580

acctgcccac caattcgagg tctaagaccg gtagagaaat gtgcagttct aaccgaccat    17640

atcaaggcag aggctatgtt atctccagca ggatcttcgt ggaacataaa tccaattatt    17700

gtagaccatt actcatgctc tctgacttat ctccggcgag gatcgatcaa acagataaga    17760

ttgagagttg atccaggatt cattttcgac gccctcgctg aggtaaatgt cagtcagcca    17820

aagatcggca gcaacaacat ctcaaatatg agcatcaagg ctttcagacc cccacacgat    17880

gatgttgcaa aattgctcaa agatatcaac acaagcaagc acaatcttcc catttcaggg    17940

ggcaatctcg ccaattatga aatccatgct ttccgcagaa tcgggttgaa ctcatctgct    18000

tgctacaaag ctgttgagat atcaacatta attaggagat gccttgagcc aggggaggac    18060

ggcttgttct tgggtgaggg atcgggttct atgttgatca cttataaaga gatacttaaa    18120

ctaaacaagt gcttctataa tagtggggtt tccgccaatt ctagatctgg tcaaagggaa    18180

ttagcaccct atccctccga agttggcctt gtcgaacaca gaatgggagt aggtaatatt    18240

gtcaaagtgc tctttaacgg gaggcccgaa gtcacgtggg taggcagtgt agattgcttc    18300

aatttcatag ttagtaatat ccctacctct agtgtggggt ttatccattc agatatagag    18360

accttgcctg acaaagatac tatagagaag ctagaggaat tggcagccat cttatcgatg    18420

gctctgctcc tgggcaaaat aggatcaata ctggtgatta agcttatgcc tttcagcggg    18480

gattttgttc agggatttat aagttatgta gggtctcatt atagagaagt gaaccttgta    18540

taccctagat acagcaactt catctctact gaatcttatt tggttatgac agatctcaag    18600

gctaaccggc taatgaatcc tgaaaagatt aagcagcaga taattgaatc atctgtgagg    18660

acttcacctg gacttatagg tcacatccta tccattaagc aactaagctg catacaagca    18720

attgtgggag acgcagttag tagaggtgat atcaatccta ctctgaaaaa acttacacct    18780

atagagcagg tgctgatcaa ttgcgggttg gcaattaacg gacctaagct gtgcaaagaa    18840

ttgatccacc atgatgttgc ctcagggcaa gatggattgc ttaattctat actcatcctc    18900

tacagggagt tggcaagatt caaagacaac caaagaagtc aacaagggat gttccacgct    18960

taccccgtat tggtaagtag caggcaacga gaacttatat ctaggatcac ccgcaaattc    19020

tgggggcaca ttcttcttta ctccgggaac aaaaagttga taaataagtt tatccagaat    19080

ctcaagtccg gctatctgat actagactta caccagaata tcttcgttaa gaatctatcc    19140

aagtcagaga aacagattat tatgacgggg ggtttgaaac gtgagtgggt ttttaaggta    19200

acagtcaagg agaccaaaga atggtataag ttagtcggat acagtgccct gattaaggac    19260

taattggttg aactccggaa ccctaatcct gccctaggtg gttaggcatt atttgcaata    19320

tattaaagaa aactttgaaa atacgaagtt tctattccca gctttgtctg gtggccggca    19380

tggtcccagc ctcctcgctg gcgccggctg ggcaacattc cgaggggacc gtcccctcgg    19440

taatggcgaa tgggacgcgg ccgatccggc tgctaacaaa gcccgaaagg aagctgagtt    19500

ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt    19560

gaggggtttt ttgctgaaag gaggaactat atccggatgc ggccgcgggc cctatggtac    19620

ccagcttttg ttccctttag tgagggttaa ttccgagctt ggcgtaatca tggtcatagc    19680

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatagga gccggaagca    19740

taaagtgtaa agcctggggt gcctaatgag tgaggtaact cacattaatt gcgttgcgct    19800

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac    19860

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc    19920

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt    19980

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg    20040

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctcggc ccccctgacg    20100

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat    20160

accaggcgtt cccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta    20220

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct    20280

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc    20340

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa    20400

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg    20460

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag    20520

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt    20580

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta    20640

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc    20700

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca    20760

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa    20820

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat    20880

ttcgttcatc catagttgcc tgactgcccg tcgtgtagat aactacgata cgggagggct    20940

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt    21000

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat    21060

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta    21120

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg    21180

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt    21240

tgtgaaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg    21300

cagtgttatc actcatgctt atggcagcac tgcataattc tcttactgtc atgccatccg    21360

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc    21420

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa    21480

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac    21540

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt    21600

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg    21660

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa    21720

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata    21780

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgaaatt gtaaacgtta    21840

atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg    21900

ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg    21960

ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa    22020

aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg    22080

ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt    22140

gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg    22200

ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta    22260

atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt tgggaagggc    22320

gatcggtgcg ggcctcttcg ctattacgcc agccaccgcg gtg                      22363


<210>  140
<211>  20701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete optimised nucleotide sequence of the polynucleotide 
       encoding pTM-MVDVax7


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  NotI

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammerhead ribozyme

<220>
<221>  misc_feature
<222>  (83)..(189)
<223>  MV Leader and N promoter

<220>
<221>  misc_feature
<222>  (190)..(1767)
<223>  MV N ORF

<220>
<221>  misc_feature
<222>  (1768)..(1888)
<223>  MV N-P intergenic

<220>
<221>  misc_feature
<222>  (1889)..(3412)
<223>  MV P ORF

<220>
<221>  misc_feature
<222>  (3413)..(3531)
<223>  MV ATU2

<220>
<221>  misc_feature
<222>  (3532)..(5154)
<223>  DENV1 NS polyepitope

<220>
<221>  misc_feature
<222>  (5155)..(5253)
<223>  MV P-M intergenic

<220>
<221>  misc_feature
<222>  (5254)..(6261)
<223>  MV M ORF

<220>
<221>  misc_feature
<222>  (6262)..(7264)
<223>  MV M-F intergenic

<220>
<221>  misc_feature
<222>  (7265)..(8926)
<223>  MV F ORF

<220>
<221>  misc_feature
<222>  (8927)..(9086)
<223>  MV-F-H intergenic

<220>
<221>  misc_feature
<222>  (9087)..(10940)
<223>  MV H ORF

<220>
<221>  misc_feature
<222>  (10941)..(11049)
<223>  MV H-L intergenic

<220>
<221>  misc_feature
<222>  (11050)..(17601)
<223>  MV L ORF

<220>
<221>  misc_feature
<222>  (17602)..(17710)
<223>  MV Trailer

<220>
<221>  misc_feature
<222>  (17711)..(17794)
<223>  HDV ribozyme

<220>
<221>  misc_feature
<222>  (17795)..(17936)
<223>  T7 terminator

<220>
<221>  misc_feature
<222>  (17937)..(17944)
<223>  Not I

<220>
<221>  misc_feature
<222>  (17945)..(20701)
<223>  pTM plasmid

<400>  140
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagc ctaccctcca tcattgttat     3480

aaaaaactta ggaaccaggt ccacacagcc gccagcccat caacgcgtac gatggcatca     3540

caggagggac cactgcccga aattgaggac gaagtgttta gaaagcgaaa tctgactatt     3600

atggacctgc accccggatc tggcaagacc cggagatacc tgccagccat cgtgagggag     3660

gctattaagc ggaaactgag aacactgatc ctggccccaa ctcgcgtggt cgcttccgaa     3720

atggctgagg ccctgaaagg catgcccatc cggtatcaga ccacagcagt gaagtctgaa     3780

cataccggca aggagattgt ggacctgatg tgccacgcca ctttcaccat gcgactgctg     3840

agcccagtgc gggtccccaa ctacaatatg atcattatgg acgaggccca ctttactgat     3900

cccagctcca tcgccgctag aggatatatt tccaccaggg tgggaatggg cgaggcagca     3960

gctatcttca tgacagcaac tccccctggc agcgtggagg catttcctca gtccaacgcc     4020

gtcatccagg acgaggagcg ggacattcct gagcggagct ggaattctgg gtacgaatgg     4080

atcacagacg aggatcatgc acactggact gaagccaaga tgctgctgga caacattaat     4140

actcctgagg gaatcattcc agctctgttc gagcccgaaa gagagaagtc tgcagccatc     4200

gacggcgagt atagactgag gggagaggcc cggaagacct tcgtggaact gatgaggcgc     4260

ggcgatctgc ccgtgtggct gagttacaag gtcgcttcag agggattcca gtatagtgac     4320

cgacggtggt gctttgatgg cgaacgcaac aatcaggtgc tggaggagaa catggatgtc     4380

gagatttgga caaaggaagg cgagcggaag aaactgcgcc cacgatggct ggacgctcgg     4440

acttacagcg atcccctggc actgagagaa ttcaaagagt ttgctgcagg ggtggccgtc     4500

gagaatcacc atcacgccgc tatgctggac gtggatctgc atcctgccag tgcttggacc     4560

ctgtatgcag tggccactac catcattacc ccaatgatgc gccacacaat cgagaacaca     4620

actgccaata tctcactgac agctattgca aaccaggcag ccattctgat gggactggac     4680

aaaggctggc ccatcagcaa gatggatatt ggcgtgcctc tgctggccct ggggtgttac     4740

agtcaggtgc tggacatcat tggccagagg atcgagaaca ttaagcatga gcacaaatca     4800

acctggcatt acgacgaaga taatccctat aagacatggg cctaccacgg aagctatgag     4860

gtgaaacctt caggcagcgc cagcagcatg gtcaacgggg tggtcaagct gctgaccaaa     4920

ccttgggacg tgatcccaat ggtcactcag attgccatga ccgataccac cccattcggc     4980

cagcagcggg tgttcaagga gaaggtggac acccgcacac ctaaggctaa acgagggact     5040

gcacagatca tggaggtgac cgccaagtgg ctgtggggat tcctgtccag gaacaagaag     5100

ccaagaatct gtaccaggga agagttcaca agaaaggtcc ggtcaaacgc ctaatgagcg     5160

cgcagcgctt agacgtctcg cgatcgatac tagtacaacc taaatccatt ataaaaaact     5220

taggagcaaa gtgattgcct cccaaggtcc acaatgacag agacctacga cttcgacaag     5280

tcggcatggg acatcaaagg gtcgatcgct ccgatacaac ccaccaccta cagtgatggc     5340

aggctggtgc cccaggtcag agtcatagat cctggtctag gcgacaggaa ggatgaatgc     5400

tttatgtaca tgtttctgct gggggttgtt gaggacagcg attccctagg gcctccaatc     5460

gggcgagcat ttgggttcct gcccttaggt gttggcagat ccacagcaaa gcccgaaaaa     5520

ctcctcaaag aggccactga gcttgacata gttgttagac gtacagcagg gctcaatgaa     5580

aaactggtgt tctacaacaa caccccacta actctcctca caccttggag aaaggtccta     5640

acaacaggga gtgtcttcaa cgcaaaccaa gtgtgcaatg cggttaatct gataccgctc     5700

gataccccgc agaggttccg tgttgtttat atgagcatca cccgtctttc ggataacggg     5760

tattacaccg ttcctagaag aatgctggaa ttcagatcgg tcaatgcagt ggccttcaac     5820

ctgctggtga cccttaggat tgacaaggcg ataggccctg ggaagatcat cgacaataca     5880

gagcaacttc ctgaggcaac atttatggtc cacatcggga acttcaggag aaagaagagt     5940

gaagtctact ctgccgatta ttgcaaaatg aaaatcgaaa agatgggcct ggtttttgca     6000

cttggtggga tagggggcac cagtcttcac attagaagca caggcaaaat gagcaagact     6060

ctccatgcac aactcgggtt caagaagacc ttatgttacc cgctgatgga tatcaatgaa     6120

gaccttaatc gattactctg gaggagcaga tgcaagatag taagaatcca ggcagttttg     6180

cagccatcag ttcctcaaga attccgcatt tacgacgacg tgatcataaa tgatgaccaa     6240

ggactattca aagttctgta gaccgtagtg cccagcaatg cccgaaaacg acccccctca     6300

caatgacagc cagaaggccc ggacaaaaaa gccccctccg aaagactcca cggaccaagc     6360

gagaggccag ccagcagccg acggcaagcg cgaacaccag gcggccccag cacagaacag     6420

ccctgacaca aggccaccac cagccacccc aatctgcatc ctcctcgtgg gacccccgag     6480

gaccaacccc caaggctgcc cccgatccaa accaccaacc gcatccccac cacccccggg     6540

aaagaaaccc ccagcaattg gaaggcccct ccccctcttc ctcaacacaa gaactccaca     6600

accgaaccgc acaagcgacc gaggtgaccc aaccgcaggc atccgactcc ctagacagat     6660

cctctctccc cggcaaacta aacaaaactt agggccaagg aacatacaca cccaacagaa     6720

cccagacccc ggcccacggc gccgcgcccc caacccccga caaccagagg gagcccccaa     6780

ccaatcccgc cggctccccc ggtgcccaca ggcagggaca ccaacccccg aacagaccca     6840

gcacccaacc atcgacaatc caagacgggg gggccccccc aaaaaaaggc ccccaggggc     6900

cgacagccag caccgcgagg aagcccaccc accccacaca cgaccacggc aaccaaacca     6960

gaacccagac caccctgggc caccagctcc cagactcggc catcaccccg cagaaaggaa     7020

aggccacaac ccgcgcaccc cagccccgat ccggcgggga gccacccaac ccgaaccagc     7080

acccaagagc gatccccgaa ggacccccga accgcaaagg acatcagtat cccacagcct     7140

ctccaagtcc cccggtctcc tcctcttctc gaagggacca aaagatcaat ccaccacacc     7200

cgacgacact caactcccca cccctaaagg agacaccggg aatcccagaa tcaagactca     7260

tccaatgtcc atcatgggtc tcaaggtgaa cgtctctgcc atattcatgg cagtactgtt     7320

aactctccaa acacccaccg gtcaaatcca ttggggcaat ctctctaaga taggggtggt     7380

aggaatagga agtgcaagct acaaagttat gactcgttcc agccatcaat cattagtcat     7440

aaaattaatg cccaatataa ctctcctcaa taactgcacg agggtagaga ttgcagaata     7500

caggagacta ctgagaacag ttttggaacc aattagagat gcacttaatg caatgaccca     7560

gaatataaga ccggttcaga gtgtagcttc aagtaggaga cacaagagat ttgcgggagt     7620

agtcctggca ggtgcggccc taggcgttgc cacagctgct cagataacag ccggcattgc     7680

acttcaccag tccatgctga actctcaagc catcgacaat ctgagagcga gcctggaaac     7740

tactaatcag gcaattgaga caatcagaca agcagggcag gagatgatat tggctgttca     7800

gggtgtccaa gactacatca ataatgagct gataccgtct atgaaccaac tatcttgtga     7860

tttaatcggc cagaagctcg ggctcaaatt gctcagatac tatacagaaa tcctgtcatt     7920

atttggcccc agtttacggg accccatatc tgcggagata tctatccagg ctttgagcta     7980

tgcgcttgga ggagacatca ataaggtgtt agaaaagctc ggatacagtg gaggtgattt     8040

actgggcatc ttagagagcg gaggaataaa ggcccggata actcacgtcg acacagagtc     8100

ctacttcatt gtcctcagta tagcctatcc gacgctgtcc gagattaagg gggtgattgt     8160

ccaccggcta gagggggtct cgtacaacat aggctctcaa gagtggtata ccactgtgcc     8220

caagtatgtt gcaacccaag ggtaccttat ctcgaatttt gatgagtcat cgtgtacttt     8280

catgccagag gggactgtgt gcagccaaaa tgccttgtac ccgatgagtc ctctgctcca     8340

agaatgcctc cgggggtaca ccaagtcctg tgctcgtaca ctcgtatccg ggtcttttgg     8400

gaaccggttc attttatcac aagggaacct aatagccaat tgtgcatcaa tcctttgcaa     8460

gtgttacaca acaggaacga tcattaatca agaccctgac aagatcctaa catacattgc     8520

tgccgatcac tgcccggtag tcgaggtgaa cggcgtgacc atccaagtcg ggagcaggag     8580

gtatccagac gctgtgtact tgcacagaat tgacctcggt cctcccatat cattggagag     8640

gttggacgta gggacaaatc tggggaatgc aattgctaag ttggaggatg ccaaggaatt     8700

gttggagtca tcggaccaga tattgaggag tatgaaaggt ttatcgagca ctagcatagt     8760

ctacatcctg attgcagtgt gtcttggagg gttgataggg atccccgctt taatatgttg     8820

ctgcaggggg cgttgtaaca aaaagggaga acaagttggt atgtcaagac caggcctaaa     8880

gcctgatctt acgggaacat caaaatccta tgtaaggtcg ctctgatcct ctacaactct     8940

tgaaacacaa atgtcccaca agtctcctct tcgtcatcaa gcaaccaccg cacccagcat     9000

caagcccacc tgaaattatc tccggcttcc ctctggccga acaatatcgg tagttaatca     9060

aaacttaggg tgcaagatca tccacaatgt caccacaacg agaccggata aatgccttct     9120

acaaagataa cccccatccc aagggaagta ggatagtcat taacagagaa catcttatga     9180

ttgatagacc ttatgttttg ctggctgttc tgtttgtcat gtttctgagc ttgatcgggt     9240

tgctagccat tgcaggcatt agacttcatc gggcagccat ctacaccgca gagatccata     9300

aaagcctcag caccaatcta gatgtaacta actcaatcga gcatcaggtc aaggacgtgc     9360

tgacaccact cttcaaaatc atcggtgatg aagtgggcct gaggacacct cagagattca     9420

ctgacctagt gaaattaatc tctgacaaga ttaaattcct taatccggat agggagtacg     9480

acttcagaga tctcacttgg tgtatcaacc cgccagagag aatcaaattg gattatgatc     9540

aatactgtgc agatgtggct gctgaagagc tcatgaatgc attggtgaac tcaactctac     9600

tggagaccag aacaaccaat cagttcctag ctgtctcaaa gggaaactgc tcagggccca     9660

ctacaatcag aggtcaattc tcaaacatgt cgctgtccct gttagacttg tatttaggtc     9720

gaggttacaa tgtgtcatct atagtcacta tgacatccca gggaatgtat gggggaactt     9780

acctagtgga aaagcctaat ctgagcagca aaaggtcaga gttgtcacaa ctgagcatgt     9840

accgagtgtt tgaagtaggt gttatcagaa atccgggttt gggggctccg gtgttccata     9900

tgacaaacta tcttgagcaa ccagtcagta atgatctcag caactgtatg gtggctttgg     9960

gggagctcaa actcgcagcc ctttgtcacg gggaagattc tatcacaatt ccctatcagg    10020

gatcagggaa aggtgtcagc ttccagctcg tcaagctagg tgtctggaaa tccccaaccg    10080

acatgcaatc ctgggtcccc ttatcaacgg atgatccagt gatagacagg ctttacctct    10140

catctcacag aggtgttatc gctgacaatc aagcaaaatg ggctgtcccg acaacacgaa    10200

cagatgacaa gttgcgaatg gagacatgct tccaacaggc gtgtaagggt aaaatccaag    10260

cactctgcga gaatcccgag tgggcaccat tgaaggataa caggattcct tcatacgggg    10320

tcttgtctgt tgatctgagt ctgacagttg agcttaaaat caaaattgct tcgggattcg    10380

ggccattgat cacacacggt tcagggatgg acctatacaa atccaaccac aacaatgtgt    10440

attggctgac tatcccgcca atgaagaacc tagccttagg tgtaatcaac acattggagt    10500

ggataccgag attcaaggtt agtccctacc tcttcactgt cccaattaag gaagcaggcg    10560

aagactgcca tgccccaaca tacctacctg cggaggtgga tggtgatgtc aaactcagtt    10620

ccaatctggt gattctacct ggtcaagatc tccaatatgt tttggcaacc tacgatactt    10680

ccagggttga acatgctgtg gtttattacg tttacagccc aagccgctca ttttcttact    10740

tttatccttt taggttgcct ataaaggggg tccccatcga attacaagtg gaatgcttca    10800

catgggacca aaaactctgg tgccgtcact tctgtgtgct tgcggactca gaatctggtg    10860

gacatatcac tcactctggg atggtgggca tgggagtcag ctgcacagtc acccgggaag    10920

atggaaccaa tcgcagatag ggctgctagt gaaccaatca catgatgtca cccagacatc    10980

aggcataccc actagtgtga aatagacatc agaattaaga aaaacgtagg gtccaagtgg    11040

ttccccgtta tggactcgct atctgtcaac cagatcttat accctgaagt tcacctagat    11100

agcccgatag ttaccaataa gatagtagcc atcctggagt atgctcgagt ccctcacgct    11160

tacagcctgg aggaccctac actgtgtcag aacatcaagc accgcctaaa aaacggattt    11220

tccaaccaaa tgattataaa caatgtggaa gttgggaatg tcatcaagtc caagcttagg    11280

agttatccgg cccactctca tattccatat ccaaattgta atcaggattt atttaacata    11340

gaagacaaag agtcaacgag gaagatccgt gaactcctca aaaaggggaa ttcgctgtac    11400

tccaaagtca gtgataaggt tttccaatgc ttaagggaca ctaactcacg gcttggccta    11460

ggctccgaat tgagggagga catcaaggag aaagttatta acttgggagt ttacatgcac    11520

agctcccagt ggtttgagcc ctttctgttt tggtttacag tcaagactga gatgaggtca    11580

gtgattaaat cacaaaccca tacttgccat aggaggagac acacacctgt attcttcact    11640

ggtagttcag ttgagttgct aatctctcgt gaccttgttg ctataatcag taaagagtct    11700

caacatgtat attacctgac atttgaactg gttttgatgt attgtgatgt catagagggg    11760

aggttaatga cagagaccgc tatgactatt gatgctaggt atacagagct tctaggaaga    11820

gtcagataca tgtggaaact gatagatggt ttcttccctg cactcgggaa tccaacttat    11880

caaattgtag ccatgctgga gcctctttca cttgcttacc tgcagctgag ggatataaca    11940

gtagaactca gaggtgcttt ccttaaccac tgctttactg aaatacatga tgttcttgac    12000

caaaacgggt tttctgatga aggtacttat catgagttaa ctgaagctct agattacatt    12060

ttcataactg atgacataca tctgacaggg gagattttct catttttcag aagtttcggc    12120

caccccagac ttgaagcagt aacggctgct gaaaatgtta ggaaatacat gaatcagcct    12180

aaagtcattg tgtatgagac tctgatgaaa ggtcatgcca tattttgtgg aatcataatc    12240

aacggctatc gtgacaggca cggaggcagt tggccaccgc tgaccctccc cctgcatgct    12300

gcagacacaa tccggaatgc tcaagcttca ggtgaagggt taacacatga gcagtgcgtt    12360

gataactgga aatcttttgc tggagtgaaa tttggctgct ttatgcctct tagcctggat    12420

agtgatctga caatgtacct aaaggacaag gcacttgctg ctctccaaag ggaatgggat    12480

tcagtttacc cgaaagagtt cctgcgttac gaccctccca agggaaccgg gtcacggagg    12540

cttgtagatg ttttccttaa tgattcgagc tttgacccat atgatgtgat aatgtatgtt    12600

gtaagtggag cttacctcca tgaccctgag ttcaacctgt cttacagcct gaaagaaaag    12660

gagatcaagg aaacaggtag actttttgct aaaatgactt acaaaatgag ggcatgccaa    12720

gtgattgctg aaaatctaat ctcaaacggg attggcaaat attttaagga caatgggatg    12780

gccaaggatg agcacgattt gactaaggca ctccacactc tagctgtctc aggagtcccc    12840

aaagatctca aagaaagtca cagggggggg ccagtcttaa aaacctactc ccgaagccca    12900

gtccacacaa gtaccaggaa cgtgagagca gcaaaagggt ttatagggtt ccctcaagta    12960

attcggcagg accaagacac tgatcatccg gagaatatgg aagcttacga gacagtcagt    13020

gcatttatca cgactgatct caagaagtac tgccttaatt ggagatatga gaccatcagc    13080

ttgtttgcac agaggctaaa tgagatttac ggattgccct catttttcca gtggctgcat    13140

aagaggcttg agacctctgt cctgtatgta agtgaccctc attgcccccc cgaccttgac    13200

gcccatatcc cgttatataa agtccccaat gatcaaatct tcattaagta ccctatggga    13260

ggtatagaag ggtattgtca gaagctgtgg accatcagca ccattcccta tctatacctg    13320

gctgcttatg agagcggagt aaggattgct tcgttagtgc aaggggacaa tcagaccata    13380

gccgtaacaa aaagggtacc cagcacatgg ccctacaacc ttaagaaacg ggaagctgct    13440

agagtaacta gagattactt tgtaattctt aggcaaaggc tacatgatat tggccatcac    13500

ctcaaggcaa atgagacaat tgtttcatca catttttttg tctattcaaa aggaatatat    13560

tatgatgggc tacttgtgtc ccaatcactc aagagcatcg caagatgtgt attctggtca    13620

gagactatag ttgatgaaac aagggcagca tgcagtaata ttgctacaac aatggctaaa    13680

agcatcgaga gaggttatga ccgttacctt gcatattccc tgaacgtcct aaaagtgata    13740

cagcaaattc tgatctctct tggcttcaca atcaattcaa ccatgacccg ggatgtagtc    13800

atacccctcc tcacaaacaa cgacctctta ataaggatgg cactgttgcc cgctcctatt    13860

ggggggatga attatctgaa tatgagcagg ctgtttgtca gaaacatcgg tgatccagta    13920

acatcatcaa ttgctgatct caagagaatg attctcgcct cactaatgcc tgaagagacc    13980

ctccatcaag taatgacaca acaaccgggg gactcttcat tcctagactg ggctagcgac    14040

ccttactcag caaatcttgt atgtgtccag agcatcacta gactcctcaa gaacataact    14100

gcaaggtttg tcctgatcca tagtccaaac ccaatgttaa aaggattatt ccatgatgac    14160

agtaaagaag aggacgaggg actggcggca ttcctcatgg acaggcatat tatagtacct    14220

agggcagctc atgaaatcct ggatcatagt gtcacagggg caagagagtc tattgcaggc    14280

atgctggata ccacaaaagg cttgattcga gccagcatga ggaagggggg gttaacctct    14340

cgagtgataa ccagattgtc caattatgac tatgaacaat tcagagcagg gatggtgcta    14400

ttgacaggaa gaaagagaaa tgtcctcatt gacaaagagt catgttcagt gcagctggcg    14460

agagctctaa gaagccatat gtgggcgagg ctagctcgag gacggcctat ttacggcctt    14520

gaggtccctg atgtactaga atctatgcga ggccacctta ttcggcgtca tgagacatgt    14580

gtcatctgcg agtgtggatc agtcaactac ggatggtttt ttgtcccctc gggttgccaa    14640

ctggatgata ttgacaagga aacatcatcc ttgagagtcc catatattgg ttctaccact    14700

gatgagagaa cagacatgaa gcttgccttc gtaagagccc caagtcgatc cttgcgatct    14760

gctgttagaa tagcaacagt gtactcatgg gcttacggtg atgatgatag ctcttggaac    14820

gaagcctggt tgttggctag gcaaagggcc aatgtgagcc tggaggagct aagggtgatc    14880

actcccatct caacttcgac taatttagcg cataggttga gggatcgtag cactcaagtg    14940

aaatactcag gtacatccct tgtccgagtg gcgaggtata ccacaatctc caacgacaat    15000

ctctcatttg tcatatcaga taagaaggtt gatactaact ttatatacca acaaggaatg    15060

cttctagggt tgggtgtttt agaaacattg tttcgactcg agaaagatac cggatcatct    15120

aacacggtat tacatcttca cgtcgaaaca gattgttgcg tgatcccgat gatagatcat    15180

cccaggatac ccagctcccg caagctagag ctgagggcag agctatgtac caacccattg    15240

atatatgata atgcaccttt aattgacaga gatgcaacaa ggctatacac ccagagccat    15300

aggaggcacc ttgtggaatt tgttacatgg tccacacccc aactatatca cattttagct    15360

aagtccacag cactatctat gattgacctg gtaacaaaat ttgagaagga ccatatgaat    15420

gaaatttcag ctctcatagg ggatgacgat atcaatagtt tcataactga gtttctgctc    15480

atagagccaa gattattcac tatctacttg ggccagtgtg cggccatcaa ttgggcattt    15540

gatgtacatt atcatagacc atcagggaaa tatcagatgg gtgagctgtt gtcatcgttc    15600

ctttctagaa tgagcaaagg agtgtttaag gtgcttgtca atgctctaag ccacccaaag    15660

atctacaaga aattctggca ttgtggtatt atagagccta tccatggtcc ttcacttgat    15720

gctcaaaact tgcacacaac tgtgtgcaac atggtttaca catgctatat gacctacctc    15780

gacctgttgt tgaatgaaga gttagaagag ttcacatttc tcttgtgtga aagcgacgag    15840

gatgtagtac cggacagatt cgacaacatc caggcaaaac acttatgtgt tctggcagat    15900

ttgtactgtc aaccagggac ctgcccacca attcgaggtc taagaccggt agagaaatgt    15960

gcagttctaa ccgaccatat caaggcagag gctatgttat ctccagcagg atcttcgtgg    16020

aacataaatc caattattgt agaccattac tcatgctctc tgacttatct ccggcgagga    16080

tcgatcaaac agataagatt gagagttgat ccaggattca ttttcgacgc cctcgctgag    16140

gtaaatgtca gtcagccaaa gatcggcagc aacaacatct caaatatgag catcaaggct    16200

ttcagacccc cacacgatga tgttgcaaaa ttgctcaaag atatcaacac aagcaagcac    16260

aatcttccca tttcaggggg caatctcgcc aattatgaaa tccatgcttt ccgcagaatc    16320

gggttgaact catctgcttg ctacaaagct gttgagatat caacattaat taggagatgc    16380

cttgagccag gggaggacgg cttgttcttg ggtgagggat cgggttctat gttgatcact    16440

tataaagaga tacttaaact aaacaagtgc ttctataata gtggggtttc cgccaattct    16500

agatctggtc aaagggaatt agcaccctat ccctccgaag ttggccttgt cgaacacaga    16560

atgggagtag gtaatattgt caaagtgctc tttaacggga ggcccgaagt cacgtgggta    16620

ggcagtgtag attgcttcaa tttcatagtt agtaatatcc ctacctctag tgtggggttt    16680

atccattcag atatagagac cttgcctgac aaagatacta tagagaagct agaggaattg    16740

gcagccatct tatcgatggc tctgctcctg ggcaaaatag gatcaatact ggtgattaag    16800

cttatgcctt tcagcgggga ttttgttcag ggatttataa gttatgtagg gtctcattat    16860

agagaagtga accttgtata ccctagatac agcaacttca tctctactga atcttatttg    16920

gttatgacag atctcaaggc taaccggcta atgaatcctg aaaagattaa gcagcagata    16980

attgaatcat ctgtgaggac ttcacctgga cttataggtc acatcctatc cattaagcaa    17040

ctaagctgca tacaagcaat tgtgggagac gcagttagta gaggtgatat caatcctact    17100

ctgaaaaaac ttacacctat agagcaggtg ctgatcaatt gcgggttggc aattaacgga    17160

cctaagctgt gcaaagaatt gatccaccat gatgttgcct cagggcaaga tggattgctt    17220

aattctatac tcatcctcta cagggagttg gcaagattca aagacaacca aagaagtcaa    17280

caagggatgt tccacgctta ccccgtattg gtaagtagca ggcaacgaga acttatatct    17340

aggatcaccc gcaaattctg ggggcacatt cttctttact ccgggaacaa aaagttgata    17400

aataagttta tccagaatct caagtccggc tatctgatac tagacttaca ccagaatatc    17460

ttcgttaaga atctatccaa gtcagagaaa cagattatta tgacgggggg tttgaaacgt    17520

gagtgggttt ttaaggtaac agtcaaggag accaaagaat ggtataagtt agtcggatac    17580

agtgccctga ttaaggacta attggttgaa ctccggaacc ctaatcctgc cctaggtggt    17640

taggcattat ttgcaatata ttaaagaaaa ctttgaaaat acgaagtttc tattcccagc    17700

tttgtctggt ggccggcatg gtcccagcct cctcgctggc gccggctggg caacattccg    17760

aggggaccgt cccctcggta atggcgaatg ggacgcggcc gatccggctg ctaacaaagc    17820

ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg    17880

ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggatgcgg    17940

ccgcgggccc tatggtaccc agcttttgtt ccctttagtg agggttaatt ccgagcttgg    18000

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca    18060

acataggagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg aggtaactca    18120

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc    18180

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt    18240

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact    18300

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag    18360

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata    18420

ggctcggccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc    18480

cgacaggact ataaagatac caggcgttcc cccctggaag ctccctcgtg cgctctcctg    18540

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc    18600

tttctcaatg ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg    18660

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc    18720

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga    18780

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg    18840

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa    18900

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg    18960

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt    19020

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat    19080

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct    19140

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta    19200

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actgcccgtc gtgtagataa    19260

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac    19320

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa    19380

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag    19440

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg    19500

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag    19560

ttacatgatc ccccatgttg tgaaaaaaag cggttagctc cttcggtcct ccgatcgttg    19620

tcagaagtaa gttggccgca gtgttatcac tcatgcttat ggcagcactg cataattctc    19680

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat    19740

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata    19800

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa    19860

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca    19920

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc    19980

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc    20040

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg    20100

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac    20160

ctgaaattgt aaacgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct    20220

cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa gaatagaccg    20280

agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag aacgtggact    20340

ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt gaaccatcac    20400

cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga    20460

gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga    20520

aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca    20580

ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc ccattcgcca ttcaggctgc    20640

gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag ccaccgcggt    20700

g                                                                    20701


<210>  141
<211>  20701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete optimised nucleotide sequence of the polynucleotide 
       encoding pTM-MVDVax8


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  NotI

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammerhead ribozyme

<220>
<221>  misc_feature
<222>  (83)..(189)
<223>  MV Leader and N promoter

<220>
<221>  misc_feature
<222>  (190)..(1767)
<223>  MV N ORF

<220>
<221>  misc_feature
<222>  (1768)..(1888)
<223>  MV N-P intergenic

<220>
<221>  misc_feature
<222>  (1889)..(3412)
<223>  MV P ORF

<220>
<221>  misc_feature
<222>  (3413)..(3519)
<223>  MV P-M intergenic

<220>
<221>  misc_feature
<222>  (3520)..(4527)
<223>  MV M ORF

<220>
<221>  misc_feature
<222>  (4528)..(5530)
<223>  MV M-F intergenic

<220>
<221>  misc_feature
<222>  (5531)..(7192)
<223>  MV F ORF

<220>
<221>  misc_feature
<222>  (7193)..(7352)
<223>  MV-F-H intergenic

<220>
<221>  misc_feature
<222>  (7353)..(9206)
<223>  MV H ORF

<220>
<221>  misc_feature
<222>  (9207)..(9333)
<223>  MV ATU3

<220>
<221>  misc_feature
<222>  (9334)..(10956)
<223>  DENV1 NS polyepitope

<220>
<221>  misc_feature
<222>  (10957)..(11049)
<223>  MV H-L intergenic

<220>
<221>  misc_feature
<222>  (11050)..(17601)
<223>  MV L ORF

<220>
<221>  misc_feature
<222>  (17602)..(17710)
<223>  MV Trailer

<220>
<221>  misc_feature
<222>  (17711)..(17794)
<223>  HDV ribozyme

<220>
<221>  misc_feature
<222>  (17795)..(17936)
<223>  T7 terminator

<220>
<221>  misc_feature
<222>  (17937)..(17944)
<223>  Not I

<220>
<221>  misc_feature
<222>  (17945)..(20701)
<223>  pTM plasmid

<400>  141
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagt acaacctaaa tccattataa     3480

aaaacttagg agcaaagtga ttgcctccca aggtccacaa tgacagagac ctacgacttc     3540

gacaagtcgg catgggacat caaagggtcg atcgctccga tacaacccac cacctacagt     3600

gatggcaggc tggtgcccca ggtcagagtc atagatcctg gtctaggcga caggaaggat     3660

gaatgcttta tgtacatgtt tctgctgggg gttgttgagg acagcgattc cctagggcct     3720

ccaatcgggc gagcatttgg gttcctgccc ttaggtgttg gcagatccac agcaaagccc     3780

gaaaaactcc tcaaagaggc cactgagctt gacatagttg ttagacgtac agcagggctc     3840

aatgaaaaac tggtgttcta caacaacacc ccactaactc tcctcacacc ttggagaaag     3900

gtcctaacaa cagggagtgt cttcaacgca aaccaagtgt gcaatgcggt taatctgata     3960

ccgctcgata ccccgcagag gttccgtgtt gtttatatga gcatcacccg tctttcggat     4020

aacgggtatt acaccgttcc tagaagaatg ctggaattca gatcggtcaa tgcagtggcc     4080

ttcaacctgc tggtgaccct taggattgac aaggcgatag gccctgggaa gatcatcgac     4140

aatacagagc aacttcctga ggcaacattt atggtccaca tcgggaactt caggagaaag     4200

aagagtgaag tctactctgc cgattattgc aaaatgaaaa tcgaaaagat gggcctggtt     4260

tttgcacttg gtgggatagg gggcaccagt cttcacatta gaagcacagg caaaatgagc     4320

aagactctcc atgcacaact cgggttcaag aagaccttat gttacccgct gatggatatc     4380

aatgaagacc ttaatcgatt actctggagg agcagatgca agatagtaag aatccaggca     4440

gttttgcagc catcagttcc tcaagaattc cgcatttacg acgacgtgat cataaatgat     4500

gaccaaggac tattcaaagt tctgtagacc gtagtgccca gcaatgcccg aaaacgaccc     4560

ccctcacaat gacagccaga aggcccggac aaaaaagccc cctccgaaag actccacgga     4620

ccaagcgaga ggccagccag cagccgacgg caagcgcgaa caccaggcgg ccccagcaca     4680

gaacagccct gacacaaggc caccaccagc caccccaatc tgcatcctcc tcgtgggacc     4740

cccgaggacc aacccccaag gctgcccccg atccaaacca ccaaccgcat ccccaccacc     4800

cccgggaaag aaacccccag caattggaag gcccctcccc ctcttcctca acacaagaac     4860

tccacaaccg aaccgcacaa gcgaccgagg tgacccaacc gcaggcatcc gactccctag     4920

acagatcctc tctccccggc aaactaaaca aaacttaggg ccaaggaaca tacacaccca     4980

acagaaccca gaccccggcc cacggcgccg cgcccccaac ccccgacaac cagagggagc     5040

ccccaaccaa tcccgccggc tcccccggtg cccacaggca gggacaccaa cccccgaaca     5100

gacccagcac ccaaccatcg acaatccaag acgggggggc ccccccaaaa aaaggccccc     5160

aggggccgac agccagcacc gcgaggaagc ccacccaccc cacacacgac cacggcaacc     5220

aaaccagaac ccagaccacc ctgggccacc agctcccaga ctcggccatc accccgcaga     5280

aaggaaaggc cacaacccgc gcaccccagc cccgatccgg cggggagcca cccaacccga     5340

accagcaccc aagagcgatc cccgaaggac ccccgaaccg caaaggacat cagtatccca     5400

cagcctctcc aagtcccccg gtctcctcct cttctcgaag ggaccaaaag atcaatccac     5460

cacacccgac gacactcaac tccccacccc taaaggagac accgggaatc ccagaatcaa     5520

gactcatcca atgtccatca tgggtctcaa ggtgaacgtc tctgccatat tcatggcagt     5580

actgttaact ctccaaacac ccaccggtca aatccattgg ggcaatctct ctaagatagg     5640

ggtggtagga ataggaagtg caagctacaa agttatgact cgttccagcc atcaatcatt     5700

agtcataaaa ttaatgccca atataactct cctcaataac tgcacgaggg tagagattgc     5760

agaatacagg agactactga gaacagtttt ggaaccaatt agagatgcac ttaatgcaat     5820

gacccagaat ataagaccgg ttcagagtgt agcttcaagt aggagacaca agagatttgc     5880

gggagtagtc ctggcaggtg cggccctagg cgttgccaca gctgctcaga taacagccgg     5940

cattgcactt caccagtcca tgctgaactc tcaagccatc gacaatctga gagcgagcct     6000

ggaaactact aatcaggcaa ttgagacaat cagacaagca gggcaggaga tgatattggc     6060

tgttcagggt gtccaagact acatcaataa tgagctgata ccgtctatga accaactatc     6120

ttgtgattta atcggccaga agctcgggct caaattgctc agatactata cagaaatcct     6180

gtcattattt ggccccagtt tacgggaccc catatctgcg gagatatcta tccaggcttt     6240

gagctatgcg cttggaggag acatcaataa ggtgttagaa aagctcggat acagtggagg     6300

tgatttactg ggcatcttag agagcggagg aataaaggcc cggataactc acgtcgacac     6360

agagtcctac ttcattgtcc tcagtatagc ctatccgacg ctgtccgaga ttaagggggt     6420

gattgtccac cggctagagg gggtctcgta caacataggc tctcaagagt ggtataccac     6480

tgtgcccaag tatgttgcaa cccaagggta ccttatctcg aattttgatg agtcatcgtg     6540

tactttcatg ccagagggga ctgtgtgcag ccaaaatgcc ttgtacccga tgagtcctct     6600

gctccaagaa tgcctccggg ggtacaccaa gtcctgtgct cgtacactcg tatccgggtc     6660

ttttgggaac cggttcattt tatcacaagg gaacctaata gccaattgtg catcaatcct     6720

ttgcaagtgt tacacaacag gaacgatcat taatcaagac cctgacaaga tcctaacata     6780

cattgctgcc gatcactgcc cggtagtcga ggtgaacggc gtgaccatcc aagtcgggag     6840

caggaggtat ccagacgctg tgtacttgca cagaattgac ctcggtcctc ccatatcatt     6900

ggagaggttg gacgtaggga caaatctggg gaatgcaatt gctaagttgg aggatgccaa     6960

ggaattgttg gagtcatcgg accagatatt gaggagtatg aaaggtttat cgagcactag     7020

catagtctac atcctgattg cagtgtgtct tggagggttg atagggatcc ccgctttaat     7080

atgttgctgc agggggcgtt gtaacaaaaa gggagaacaa gttggtatgt caagaccagg     7140

cctaaagcct gatcttacgg gaacatcaaa atcctatgta aggtcgctct gatcctctac     7200

aactcttgaa acacaaatgt cccacaagtc tcctcttcgt catcaagcaa ccaccgcacc     7260

cagcatcaag cccacctgaa attatctccg gcttccctct ggccgaacaa tatcggtagt     7320

taatcaaaac ttagggtgca agatcatcca caatgtcacc acaacgagac cggataaatg     7380

ccttctacaa agataacccc catcccaagg gaagtaggat agtcattaac agagaacatc     7440

ttatgattga tagaccttat gttttgctgg ctgttctgtt tgtcatgttt ctgagcttga     7500

tcgggttgct agccattgca ggcattagac ttcatcgggc agccatctac accgcagaga     7560

tccataaaag cctcagcacc aatctagatg taactaactc aatcgagcat caggtcaagg     7620

acgtgctgac accactcttc aaaatcatcg gtgatgaagt gggcctgagg acacctcaga     7680

gattcactga cctagtgaaa ttaatctctg acaagattaa attccttaat ccggataggg     7740

agtacgactt cagagatctc acttggtgta tcaacccgcc agagagaatc aaattggatt     7800

atgatcaata ctgtgcagat gtggctgctg aagagctcat gaatgcattg gtgaactcaa     7860

ctctactgga gaccagaaca accaatcagt tcctagctgt ctcaaaggga aactgctcag     7920

ggcccactac aatcagaggt caattctcaa acatgtcgct gtccctgtta gacttgtatt     7980

taggtcgagg ttacaatgtg tcatctatag tcactatgac atcccaggga atgtatgggg     8040

gaacttacct agtggaaaag cctaatctga gcagcaaaag gtcagagttg tcacaactga     8100

gcatgtaccg agtgtttgaa gtaggtgtta tcagaaatcc gggtttgggg gctccggtgt     8160

tccatatgac aaactatctt gagcaaccag tcagtaatga tctcagcaac tgtatggtgg     8220

ctttggggga gctcaaactc gcagcccttt gtcacgggga agattctatc acaattccct     8280

atcagggatc agggaaaggt gtcagcttcc agctcgtcaa gctaggtgtc tggaaatccc     8340

caaccgacat gcaatcctgg gtccccttat caacggatga tccagtgata gacaggcttt     8400

acctctcatc tcacagaggt gttatcgctg acaatcaagc aaaatgggct gtcccgacaa     8460

cacgaacaga tgacaagttg cgaatggaga catgcttcca acaggcgtgt aagggtaaaa     8520

tccaagcact ctgcgagaat cccgagtggg caccattgaa ggataacagg attccttcat     8580

acggggtctt gtctgttgat ctgagtctga cagttgagct taaaatcaaa attgcttcgg     8640

gattcgggcc attgatcaca cacggttcag ggatggacct atacaaatcc aaccacaaca     8700

atgtgtattg gctgactatc ccgccaatga agaacctagc cttaggtgta atcaacacat     8760

tggagtggat accgagattc aaggttagtc cctacctctt cactgtccca attaaggaag     8820

caggcgaaga ctgccatgcc ccaacatacc tacctgcgga ggtggatggt gatgtcaaac     8880

tcagttccaa tctggtgatt ctacctggtc aagatctcca atatgttttg gcaacctacg     8940

atacttccag ggttgaacat gctgtggttt attacgttta cagcccaagc cgctcatttt     9000

cttactttta tccttttagg ttgcctataa agggggtccc catcgaatta caagtggaat     9060

gcttcacatg ggaccaaaaa ctctggtgcc gtcacttctg tgtgcttgcg gactcagaat     9120

ctggtggaca tatcactcac tctgggatgg tgggcatggg agtcagctgc acagtcaccc     9180

gggaagatgg aaccaatcgc agatagggct gctagtgaac caatcacatg atgtcaccca     9240

gacatcaggc atacccacta gtctaccctc catcattgtt ataaaaaact taggaaccag     9300

gtccacacag ccgccagccc atcaacgcgt acgatggcat cacaggaggg accactgccc     9360

gaaattgagg acgaagtgtt tagaaagcga aatctgacta ttatggacct gcaccccgga     9420

tctggcaaga cccggagata cctgccagcc atcgtgaggg aggctattaa gcggaaactg     9480

agaacactga tcctggcccc aactcgcgtg gtcgcttccg aaatggctga ggccctgaaa     9540

ggcatgccca tccggtatca gaccacagca gtgaagtctg aacataccgg caaggagatt     9600

gtggacctga tgtgccacgc cactttcacc atgcgactgc tgagcccagt gcgggtcccc     9660

aactacaata tgatcattat ggacgaggcc cactttactg atcccagctc catcgccgct     9720

agaggatata tttccaccag ggtgggaatg ggcgaggcag cagctatctt catgacagca     9780

actccccctg gcagcgtgga ggcatttcct cagtccaacg ccgtcatcca ggacgaggag     9840

cgggacattc ctgagcggag ctggaattct gggtacgaat ggatcacaga cgaggatcat     9900

gcacactgga ctgaagccaa gatgctgctg gacaacatta atactcctga gggaatcatt     9960

ccagctctgt tcgagcccga aagagagaag tctgcagcca tcgacggcga gtatagactg    10020

aggggagagg cccggaagac cttcgtggaa ctgatgaggc gcggcgatct gcccgtgtgg    10080

ctgagttaca aggtcgcttc agagggattc cagtatagtg accgacggtg gtgctttgat    10140

ggcgaacgca acaatcaggt gctggaggag aacatggatg tcgagatttg gacaaaggaa    10200

ggcgagcgga agaaactgcg cccacgatgg ctggacgctc ggacttacag cgatcccctg    10260

gcactgagag aattcaaaga gtttgctgca ggggtggccg tcgagaatca ccatcacgcc    10320

gctatgctgg acgtggatct gcatcctgcc agtgcttgga ccctgtatgc agtggccact    10380

accatcatta ccccaatgat gcgccacaca atcgagaaca caactgccaa tatctcactg    10440

acagctattg caaaccaggc agccattctg atgggactgg acaaaggctg gcccatcagc    10500

aagatggata ttggcgtgcc tctgctggcc ctggggtgtt acagtcaggt gctggacatc    10560

attggccaga ggatcgagaa cattaagcat gagcacaaat caacctggca ttacgacgaa    10620

gataatccct ataagacatg ggcctaccac ggaagctatg aggtgaaacc ttcaggcagc    10680

gccagcagca tggtcaacgg ggtggtcaag ctgctgacca aaccttggga cgtgatccca    10740

atggtcactc agattgccat gaccgatacc accccattcg gccagcagcg ggtgttcaag    10800

gagaaggtgg acacccgcac acctaaggct aaacgaggga ctgcacagat catggaggtg    10860

accgccaagt ggctgtgggg attcctgtcc aggaacaaga agccaagaat ctgtaccagg    10920

gaagagttca caagaaaggt ccggtcaaac gcctaatgag cgcgcagcgc ttagacgtct    10980

cgcgatcgat gctagtgtga aatagacatc agaattaaga aaaacgtagg gtccaagtgg    11040

ttccccgtta tggactcgct atctgtcaac cagatcttat accctgaagt tcacctagat    11100

agcccgatag ttaccaataa gatagtagcc atcctggagt atgctcgagt ccctcacgct    11160

tacagcctgg aggaccctac actgtgtcag aacatcaagc accgcctaaa aaacggattt    11220

tccaaccaaa tgattataaa caatgtggaa gttgggaatg tcatcaagtc caagcttagg    11280

agttatccgg cccactctca tattccatat ccaaattgta atcaggattt atttaacata    11340

gaagacaaag agtcaacgag gaagatccgt gaactcctca aaaaggggaa ttcgctgtac    11400

tccaaagtca gtgataaggt tttccaatgc ttaagggaca ctaactcacg gcttggccta    11460

ggctccgaat tgagggagga catcaaggag aaagttatta acttgggagt ttacatgcac    11520

agctcccagt ggtttgagcc ctttctgttt tggtttacag tcaagactga gatgaggtca    11580

gtgattaaat cacaaaccca tacttgccat aggaggagac acacacctgt attcttcact    11640

ggtagttcag ttgagttgct aatctctcgt gaccttgttg ctataatcag taaagagtct    11700

caacatgtat attacctgac atttgaactg gttttgatgt attgtgatgt catagagggg    11760

aggttaatga cagagaccgc tatgactatt gatgctaggt atacagagct tctaggaaga    11820

gtcagataca tgtggaaact gatagatggt ttcttccctg cactcgggaa tccaacttat    11880

caaattgtag ccatgctgga gcctctttca cttgcttacc tgcagctgag ggatataaca    11940

gtagaactca gaggtgcttt ccttaaccac tgctttactg aaatacatga tgttcttgac    12000

caaaacgggt tttctgatga aggtacttat catgagttaa ctgaagctct agattacatt    12060

ttcataactg atgacataca tctgacaggg gagattttct catttttcag aagtttcggc    12120

caccccagac ttgaagcagt aacggctgct gaaaatgtta ggaaatacat gaatcagcct    12180

aaagtcattg tgtatgagac tctgatgaaa ggtcatgcca tattttgtgg aatcataatc    12240

aacggctatc gtgacaggca cggaggcagt tggccaccgc tgaccctccc cctgcatgct    12300

gcagacacaa tccggaatgc tcaagcttca ggtgaagggt taacacatga gcagtgcgtt    12360

gataactgga aatcttttgc tggagtgaaa tttggctgct ttatgcctct tagcctggat    12420

agtgatctga caatgtacct aaaggacaag gcacttgctg ctctccaaag ggaatgggat    12480

tcagtttacc cgaaagagtt cctgcgttac gaccctccca agggaaccgg gtcacggagg    12540

cttgtagatg ttttccttaa tgattcgagc tttgacccat atgatgtgat aatgtatgtt    12600

gtaagtggag cttacctcca tgaccctgag ttcaacctgt cttacagcct gaaagaaaag    12660

gagatcaagg aaacaggtag actttttgct aaaatgactt acaaaatgag ggcatgccaa    12720

gtgattgctg aaaatctaat ctcaaacggg attggcaaat attttaagga caatgggatg    12780

gccaaggatg agcacgattt gactaaggca ctccacactc tagctgtctc aggagtcccc    12840

aaagatctca aagaaagtca cagggggggg ccagtcttaa aaacctactc ccgaagccca    12900

gtccacacaa gtaccaggaa cgtgagagca gcaaaagggt ttatagggtt ccctcaagta    12960

attcggcagg accaagacac tgatcatccg gagaatatgg aagcttacga gacagtcagt    13020

gcatttatca cgactgatct caagaagtac tgccttaatt ggagatatga gaccatcagc    13080

ttgtttgcac agaggctaaa tgagatttac ggattgccct catttttcca gtggctgcat    13140

aagaggcttg agacctctgt cctgtatgta agtgaccctc attgcccccc cgaccttgac    13200

gcccatatcc cgttatataa agtccccaat gatcaaatct tcattaagta ccctatggga    13260

ggtatagaag ggtattgtca gaagctgtgg accatcagca ccattcccta tctatacctg    13320

gctgcttatg agagcggagt aaggattgct tcgttagtgc aaggggacaa tcagaccata    13380

gccgtaacaa aaagggtacc cagcacatgg ccctacaacc ttaagaaacg ggaagctgct    13440

agagtaacta gagattactt tgtaattctt aggcaaaggc tacatgatat tggccatcac    13500

ctcaaggcaa atgagacaat tgtttcatca catttttttg tctattcaaa aggaatatat    13560

tatgatgggc tacttgtgtc ccaatcactc aagagcatcg caagatgtgt attctggtca    13620

gagactatag ttgatgaaac aagggcagca tgcagtaata ttgctacaac aatggctaaa    13680

agcatcgaga gaggttatga ccgttacctt gcatattccc tgaacgtcct aaaagtgata    13740

cagcaaattc tgatctctct tggcttcaca atcaattcaa ccatgacccg ggatgtagtc    13800

atacccctcc tcacaaacaa cgacctctta ataaggatgg cactgttgcc cgctcctatt    13860

ggggggatga attatctgaa tatgagcagg ctgtttgtca gaaacatcgg tgatccagta    13920

acatcatcaa ttgctgatct caagagaatg attctcgcct cactaatgcc tgaagagacc    13980

ctccatcaag taatgacaca acaaccgggg gactcttcat tcctagactg ggctagcgac    14040

ccttactcag caaatcttgt atgtgtccag agcatcacta gactcctcaa gaacataact    14100

gcaaggtttg tcctgatcca tagtccaaac ccaatgttaa aaggattatt ccatgatgac    14160

agtaaagaag aggacgaggg actggcggca ttcctcatgg acaggcatat tatagtacct    14220

agggcagctc atgaaatcct ggatcatagt gtcacagggg caagagagtc tattgcaggc    14280

atgctggata ccacaaaagg cttgattcga gccagcatga ggaagggggg gttaacctct    14340

cgagtgataa ccagattgtc caattatgac tatgaacaat tcagagcagg gatggtgcta    14400

ttgacaggaa gaaagagaaa tgtcctcatt gacaaagagt catgttcagt gcagctggcg    14460

agagctctaa gaagccatat gtgggcgagg ctagctcgag gacggcctat ttacggcctt    14520

gaggtccctg atgtactaga atctatgcga ggccacctta ttcggcgtca tgagacatgt    14580

gtcatctgcg agtgtggatc agtcaactac ggatggtttt ttgtcccctc gggttgccaa    14640

ctggatgata ttgacaagga aacatcatcc ttgagagtcc catatattgg ttctaccact    14700

gatgagagaa cagacatgaa gcttgccttc gtaagagccc caagtcgatc cttgcgatct    14760

gctgttagaa tagcaacagt gtactcatgg gcttacggtg atgatgatag ctcttggaac    14820

gaagcctggt tgttggctag gcaaagggcc aatgtgagcc tggaggagct aagggtgatc    14880

actcccatct caacttcgac taatttagcg cataggttga gggatcgtag cactcaagtg    14940

aaatactcag gtacatccct tgtccgagtg gcgaggtata ccacaatctc caacgacaat    15000

ctctcatttg tcatatcaga taagaaggtt gatactaact ttatatacca acaaggaatg    15060

cttctagggt tgggtgtttt agaaacattg tttcgactcg agaaagatac cggatcatct    15120

aacacggtat tacatcttca cgtcgaaaca gattgttgcg tgatcccgat gatagatcat    15180

cccaggatac ccagctcccg caagctagag ctgagggcag agctatgtac caacccattg    15240

atatatgata atgcaccttt aattgacaga gatgcaacaa ggctatacac ccagagccat    15300

aggaggcacc ttgtggaatt tgttacatgg tccacacccc aactatatca cattttagct    15360

aagtccacag cactatctat gattgacctg gtaacaaaat ttgagaagga ccatatgaat    15420

gaaatttcag ctctcatagg ggatgacgat atcaatagtt tcataactga gtttctgctc    15480

atagagccaa gattattcac tatctacttg ggccagtgtg cggccatcaa ttgggcattt    15540

gatgtacatt atcatagacc atcagggaaa tatcagatgg gtgagctgtt gtcatcgttc    15600

ctttctagaa tgagcaaagg agtgtttaag gtgcttgtca atgctctaag ccacccaaag    15660

atctacaaga aattctggca ttgtggtatt atagagccta tccatggtcc ttcacttgat    15720

gctcaaaact tgcacacaac tgtgtgcaac atggtttaca catgctatat gacctacctc    15780

gacctgttgt tgaatgaaga gttagaagag ttcacatttc tcttgtgtga aagcgacgag    15840

gatgtagtac cggacagatt cgacaacatc caggcaaaac acttatgtgt tctggcagat    15900

ttgtactgtc aaccagggac ctgcccacca attcgaggtc taagaccggt agagaaatgt    15960

gcagttctaa ccgaccatat caaggcagag gctatgttat ctccagcagg atcttcgtgg    16020

aacataaatc caattattgt agaccattac tcatgctctc tgacttatct ccggcgagga    16080

tcgatcaaac agataagatt gagagttgat ccaggattca ttttcgacgc cctcgctgag    16140

gtaaatgtca gtcagccaaa gatcggcagc aacaacatct caaatatgag catcaaggct    16200

ttcagacccc cacacgatga tgttgcaaaa ttgctcaaag atatcaacac aagcaagcac    16260

aatcttccca tttcaggggg caatctcgcc aattatgaaa tccatgcttt ccgcagaatc    16320

gggttgaact catctgcttg ctacaaagct gttgagatat caacattaat taggagatgc    16380

cttgagccag gggaggacgg cttgttcttg ggtgagggat cgggttctat gttgatcact    16440

tataaagaga tacttaaact aaacaagtgc ttctataata gtggggtttc cgccaattct    16500

agatctggtc aaagggaatt agcaccctat ccctccgaag ttggccttgt cgaacacaga    16560

atgggagtag gtaatattgt caaagtgctc tttaacggga ggcccgaagt cacgtgggta    16620

ggcagtgtag attgcttcaa tttcatagtt agtaatatcc ctacctctag tgtggggttt    16680

atccattcag atatagagac cttgcctgac aaagatacta tagagaagct agaggaattg    16740

gcagccatct tatcgatggc tctgctcctg ggcaaaatag gatcaatact ggtgattaag    16800

cttatgcctt tcagcgggga ttttgttcag ggatttataa gttatgtagg gtctcattat    16860

agagaagtga accttgtata ccctagatac agcaacttca tctctactga atcttatttg    16920

gttatgacag atctcaaggc taaccggcta atgaatcctg aaaagattaa gcagcagata    16980

attgaatcat ctgtgaggac ttcacctgga cttataggtc acatcctatc cattaagcaa    17040

ctaagctgca tacaagcaat tgtgggagac gcagttagta gaggtgatat caatcctact    17100

ctgaaaaaac ttacacctat agagcaggtg ctgatcaatt gcgggttggc aattaacgga    17160

cctaagctgt gcaaagaatt gatccaccat gatgttgcct cagggcaaga tggattgctt    17220

aattctatac tcatcctcta cagggagttg gcaagattca aagacaacca aagaagtcaa    17280

caagggatgt tccacgctta ccccgtattg gtaagtagca ggcaacgaga acttatatct    17340

aggatcaccc gcaaattctg ggggcacatt cttctttact ccgggaacaa aaagttgata    17400

aataagttta tccagaatct caagtccggc tatctgatac tagacttaca ccagaatatc    17460

ttcgttaaga atctatccaa gtcagagaaa cagattatta tgacgggggg tttgaaacgt    17520

gagtgggttt ttaaggtaac agtcaaggag accaaagaat ggtataagtt agtcggatac    17580

agtgccctga ttaaggacta attggttgaa ctccggaacc ctaatcctgc cctaggtggt    17640

taggcattat ttgcaatata ttaaagaaaa ctttgaaaat acgaagtttc tattcccagc    17700

tttgtctggt ggccggcatg gtcccagcct cctcgctggc gccggctggg caacattccg    17760

aggggaccgt cccctcggta atggcgaatg ggacgcggcc gatccggctg ctaacaaagc    17820

ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg    17880

ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggatgcgg    17940

ccgcgggccc tatggtaccc agcttttgtt ccctttagtg agggttaatt ccgagcttgg    18000

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca    18060

acataggagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg aggtaactca    18120

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc    18180

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt    18240

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact    18300

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag    18360

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata    18420

ggctcggccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc    18480

cgacaggact ataaagatac caggcgttcc cccctggaag ctccctcgtg cgctctcctg    18540

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc    18600

tttctcaatg ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg    18660

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc    18720

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga    18780

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg    18840

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa    18900

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg    18960

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt    19020

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat    19080

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct    19140

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta    19200

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actgcccgtc gtgtagataa    19260

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac    19320

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa    19380

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag    19440

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg    19500

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag    19560

ttacatgatc ccccatgttg tgaaaaaaag cggttagctc cttcggtcct ccgatcgttg    19620

tcagaagtaa gttggccgca gtgttatcac tcatgcttat ggcagcactg cataattctc    19680

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat    19740

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata    19800

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa    19860

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca    19920

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc    19980

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc    20040

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg    20100

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac    20160

ctgaaattgt aaacgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct    20220

cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa gaatagaccg    20280

agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag aacgtggact    20340

ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt gaaccatcac    20400

cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga    20460

gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga    20520

aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca    20580

ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc ccattcgcca ttcaggctgc    20640

gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag ccaccgcggt    20700

g                                                                    20701


<210>  142
<211>  22261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete optimised nucleotide sequence of the polynucleotide 
       encoding pTM-MVDVax9


<220>
<221>  misc_feature
<222>  (1 )..(8)
<223>  NotI

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammerhead ribozyme

<220>
<221>  misc_feature
<222>  (83)..(189)
<223>  MV Leader and N promoter

<220>
<221>  misc_feature
<222>  (190)..(1767)
<223>  MV N ORF

<220>
<221>  misc_feature
<222>  (1768)..(1888)
<223>  MV N-P intergenic

<220>
<221>  misc_feature
<222>  (1889)..(3412)
<223>  MV P ORF

<220>
<221>  misc_feature
<222>  (3413)..(3531)
<223>  MV ATU2

<220>
<221>  misc_feature
<222>  (3532)..(6717)
<223>  DENV tetra EDIII/ectoM/DENV1 NS polyepitope

<220>
<221>  misc_feature
<222>  (6718)..(6813)
<223>  MV P-M intergenic

<220>
<221>  misc_feature
<222>  (6814)..(7821)
<223>  MV M ORF

<220>
<221>  misc_feature
<222>  (7822)..(8824)
<223>  MV M-F intergenic

<220>
<221>  misc_feature
<222>  (8825)..(10486)
<223>  MV F ORF

<220>
<221>  misc_feature
<222>  (10487)..(10646)
<223>  MV-F-H intergenic

<220>
<221>  misc_feature
<222>  (10647)..(12500)
<223>  MV H ORF

<220>
<221>  misc_feature
<222>  (12501)..(12609)
<223>  MV H-L intergenic

<220>
<221>  misc_feature
<222>  (12610)..(19161)
<223>  MV L ORF

<220>
<221>  misc_feature
<222>  (19162)..(19270)
<223>  MV Trailer

<220>
<221>  misc_feature
<222>  (19271)..(19354)
<223>  HDV ribozyme

<220>
<221>  misc_feature
<222>  (19355)..(19496)
<223>  T7 terminator

<220>
<221>  misc_feature
<222>  (19497)..(19504)
<223>  Not I

<220>
<221>  misc_feature
<222>  (19506)..(22261)
<223>  pTM plasmid

<400>  142
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagc ctaccctcca tcattgttat     3480

aaaaaactta ggaaccaggt ccacacagcc gccagcccat caacgcgtac gatgggcatc     3540

atattcattc ttcttatgct ggttacaccg tctatggcgg agaaacttcg aatcaaaggt     3600

atgagctata cgatgtgcag cggcaagttc aagatcgaga aggaaatggc tgaaacccag     3660

cacggtacaa ctgtggtcaa agtcaaatat gagggggctg gcgctccctg taaagtaccc     3720

attgagatta gggacgtcaa taaagagaag gtggtaggtc gcatcatctc cagtacacct     3780

ttggccgaga acacgaactc cgtcacaaac atagagttgg aacccccgtt cggagactca     3840

tacattgtga tcggggtggg caactctgca ctcacactgc attggttcaa gaagggaagc     3900

agtatcggcc gcagggataa gagagacaaa ctgaaattga aaggtatgtc ctatgccatg     3960

tgcacgaata ctttcgttct caagaaagaa gtatctgaga ctcagcacgg aaccatcctg     4020

atcaaagtcg agtacaaagg agaagacgtg ccctgtaaga tcccattcag taccgaggat     4080

ggacagggca aggcccataa cggcaggctg ataaccgcca accctgtggt tacaaagaag     4140

gaagagccag tcaatatcga agctgagcca ccgttcgggg agagcaacat agtaattggc     4200

ataggggata atgctttgaa gatcaactgg tacaagaaag gaagctccat tggccgaaga     4260

gataagcgcg acaaactcca gctgaaagga atgagctact ccatgtgtac tgggaagttc     4320

aagattgtca aggaaatcgc cgaaactcag catggcacta ttgtgatccg cgtgcagtat     4380

gaaggcgatg gtagcccctg caagatacca tttgaaatca ccgatttgga gaaacggcac     4440

gtcctgggtc ggctcattac cgtgaaccca atcgtgaccg agaaggacag tccagttaat     4500

atcgaggccg agcctccttt cggcgacagt tacatcattg taggggtgga accagggcaa     4560

ctgaagctga actggttcaa gaaaggcagc agtataggac ggcgggataa acgggacaaa     4620

ctcacactga aaggcatgtc atacgttatg tgcaccggct cattcaaact ggagaaggaa     4680

gttgcagaga cacagcatgg gaccgtgctc gtgcaggtca aatacgaggg caccgacgct     4740

ccttgcaaga ttccgttcag tacacaggac gagaaaggcg tgactcagaa cggcagattg     4800

attacagcga accctatcgt gactgacaag gagaagccag ttaacatcga gactgagccg     4860

cctttcggag aatcatacat tatcgtggga gccggcgaga aggcactgaa actcagctgg     4920

ttcaagaagg gcagctcaat cggtcggaga gacaagcggt ctgtcgccct cgcaccgcac     4980

gtgggcctgg gtctggaaac gaggaccgag acgtggatga gttccgaagg cgcatggaag     5040

caaatccaga aagtggagac gtgggccctc aggcatccgc ggagagataa acgagcatca     5100

caggagggac cactgcccga aattgaggac gaagtgttta gaaagcgaaa tctgactatt     5160

atggacctgc accccggatc tggcaagacc cggagatacc tgccagccat cgtgagggag     5220

gctattaagc ggaaactgag aacactgatc ctggccccaa ctcgcgtggt cgcttccgaa     5280

atggctgagg ccctgaaagg catgcccatc cggtatcaga ccacagcagt gaagtctgaa     5340

cataccggca aggagattgt ggacctgatg tgccacgcca ctttcaccat gcgactgctg     5400

agcccagtgc gggtccccaa ctacaatatg atcattatgg acgaggccca ctttactgat     5460

cccagctcca tcgccgctag aggatatatt tccaccaggg tgggaatggg cgaggcagca     5520

gctatcttca tgacagcaac tccccctggc agcgtggagg catttcctca gtccaacgcc     5580

gtcatccagg acgaggagcg ggacattcct gagcggagct ggaattctgg gtacgaatgg     5640

atcacagacg aggatcatgc acactggact gaagccaaga tgctgctgga caacattaat     5700

actcctgagg gaatcattcc agctctgttc gagcccgaaa gagagaagtc tgcagccatc     5760

gacggcgagt atagactgag gggagaggcc cggaagacct tcgtggaact gatgaggcgc     5820

ggcgatctgc ccgtgtggct gagttacaag gtcgcttcag agggattcca gtatagtgac     5880

cgacggtggt gctttgatgg cgaacgcaac aatcaggtgc tggaggagaa catggatgtc     5940

gagatttgga caaaggaagg cgagcggaag aaactgcgcc cacgatggct ggacgctcgg     6000

acttacagcg atcccctggc actgagagaa ttcaaagagt ttgctgcagg ggtggccgtc     6060

gagaatcacc atcacgccgc tatgctggac gtggatctgc atcctgccag tgcttggacc     6120

ctgtatgcag tggccactac catcattacc ccaatgatgc gccacacaat cgagaacaca     6180

actgccaata tctcactgac agctattgca aaccaggcag ccattctgat gggactggac     6240

aaaggctggc ccatcagcaa gatggatatt ggcgtgcctc tgctggccct ggggtgttac     6300

agtcaggtgc tggacatcat tggccagagg atcgagaaca ttaagcatga gcacaaatca     6360

acctggcatt acgacgaaga taatccctat aagacatggg cctaccacgg aagctatgag     6420

gtgaaacctt caggcagcgc cagcagcatg gtcaacgggg tggtcaagct gctgaccaaa     6480

ccttgggacg tgatcccaat ggtcactcag attgccatga ccgataccac cccattcggc     6540

cagcagcggg tgttcaagga gaaggtggac acccgcacac ctaaggctaa acgagggact     6600

gcacagatca tggaggtgac cgccaagtgg ctgtggggat tcctgtccag gaacaagaag     6660

ccaagaatct gtaccaggga agagttcaca agaaaggtcc ggtcaaacgc ctaatgagcg     6720

cgcagcgctt agacgtctcg cgatcgatac tagtacaacc taaatccatt ataaaaaact     6780

taggagcaaa gtgattgcct cccaaggtcc acaatgacag agacctacga cttcgacaag     6840

tcggcatggg acatcaaagg gtcgatcgct ccgatacaac ccaccaccta cagtgatggc     6900

aggctggtgc cccaggtcag agtcatagat cctggtctag gcgacaggaa ggatgaatgc     6960

tttatgtaca tgtttctgct gggggttgtt gaggacagcg attccctagg gcctccaatc     7020

gggcgagcat ttgggttcct gcccttaggt gttggcagat ccacagcaaa gcccgaaaaa     7080

ctcctcaaag aggccactga gcttgacata gttgttagac gtacagcagg gctcaatgaa     7140

aaactggtgt tctacaacaa caccccacta actctcctca caccttggag aaaggtccta     7200

acaacaggga gtgtcttcaa cgcaaaccaa gtgtgcaatg cggttaatct gataccgctc     7260

gataccccgc agaggttccg tgttgtttat atgagcatca cccgtctttc ggataacggg     7320

tattacaccg ttcctagaag aatgctggaa ttcagatcgg tcaatgcagt ggccttcaac     7380

ctgctggtga cccttaggat tgacaaggcg ataggccctg ggaagatcat cgacaataca     7440

gagcaacttc ctgaggcaac atttatggtc cacatcggga acttcaggag aaagaagagt     7500

gaagtctact ctgccgatta ttgcaaaatg aaaatcgaaa agatgggcct ggtttttgca     7560

cttggtggga tagggggcac cagtcttcac attagaagca caggcaaaat gagcaagact     7620

ctccatgcac aactcgggtt caagaagacc ttatgttacc cgctgatgga tatcaatgaa     7680

gaccttaatc gattactctg gaggagcaga tgcaagatag taagaatcca ggcagttttg     7740

cagccatcag ttcctcaaga attccgcatt tacgacgacg tgatcataaa tgatgaccaa     7800

ggactattca aagttctgta gaccgtagtg cccagcaatg cccgaaaacg acccccctca     7860

caatgacagc cagaaggccc ggacaaaaaa gccccctccg aaagactcca cggaccaagc     7920

gagaggccag ccagcagccg acggcaagcg cgaacaccag gcggccccag cacagaacag     7980

ccctgacaca aggccaccac cagccacccc aatctgcatc ctcctcgtgg gacccccgag     8040

gaccaacccc caaggctgcc cccgatccaa accaccaacc gcatccccac cacccccggg     8100

aaagaaaccc ccagcaattg gaaggcccct ccccctcttc ctcaacacaa gaactccaca     8160

accgaaccgc acaagcgacc gaggtgaccc aaccgcaggc atccgactcc ctagacagat     8220

cctctctccc cggcaaacta aacaaaactt agggccaagg aacatacaca cccaacagaa     8280

cccagacccc ggcccacggc gccgcgcccc caacccccga caaccagagg gagcccccaa     8340

ccaatcccgc cggctccccc ggtgcccaca ggcagggaca ccaacccccg aacagaccca     8400

gcacccaacc atcgacaatc caagacgggg gggccccccc aaaaaaaggc ccccaggggc     8460

cgacagccag caccgcgagg aagcccaccc accccacaca cgaccacggc aaccaaacca     8520

gaacccagac caccctgggc caccagctcc cagactcggc catcaccccg cagaaaggaa     8580

aggccacaac ccgcgcaccc cagccccgat ccggcgggga gccacccaac ccgaaccagc     8640

acccaagagc gatccccgaa ggacccccga accgcaaagg acatcagtat cccacagcct     8700

ctccaagtcc cccggtctcc tcctcttctc gaagggacca aaagatcaat ccaccacacc     8760

cgacgacact caactcccca cccctaaagg agacaccggg aatcccagaa tcaagactca     8820

tccaatgtcc atcatgggtc tcaaggtgaa cgtctctgcc atattcatgg cagtactgtt     8880

aactctccaa acacccaccg gtcaaatcca ttggggcaat ctctctaaga taggggtggt     8940

aggaatagga agtgcaagct acaaagttat gactcgttcc agccatcaat cattagtcat     9000

aaaattaatg cccaatataa ctctcctcaa taactgcacg agggtagaga ttgcagaata     9060

caggagacta ctgagaacag ttttggaacc aattagagat gcacttaatg caatgaccca     9120

gaatataaga ccggttcaga gtgtagcttc aagtaggaga cacaagagat ttgcgggagt     9180

agtcctggca ggtgcggccc taggcgttgc cacagctgct cagataacag ccggcattgc     9240

acttcaccag tccatgctga actctcaagc catcgacaat ctgagagcga gcctggaaac     9300

tactaatcag gcaattgaga caatcagaca agcagggcag gagatgatat tggctgttca     9360

gggtgtccaa gactacatca ataatgagct gataccgtct atgaaccaac tatcttgtga     9420

tttaatcggc cagaagctcg ggctcaaatt gctcagatac tatacagaaa tcctgtcatt     9480

atttggcccc agtttacggg accccatatc tgcggagata tctatccagg ctttgagcta     9540

tgcgcttgga ggagacatca ataaggtgtt agaaaagctc ggatacagtg gaggtgattt     9600

actgggcatc ttagagagcg gaggaataaa ggcccggata actcacgtcg acacagagtc     9660

ctacttcatt gtcctcagta tagcctatcc gacgctgtcc gagattaagg gggtgattgt     9720

ccaccggcta gagggggtct cgtacaacat aggctctcaa gagtggtata ccactgtgcc     9780

caagtatgtt gcaacccaag ggtaccttat ctcgaatttt gatgagtcat cgtgtacttt     9840

catgccagag gggactgtgt gcagccaaaa tgccttgtac ccgatgagtc ctctgctcca     9900

agaatgcctc cgggggtaca ccaagtcctg tgctcgtaca ctcgtatccg ggtcttttgg     9960

gaaccggttc attttatcac aagggaacct aatagccaat tgtgcatcaa tcctttgcaa    10020

gtgttacaca acaggaacga tcattaatca agaccctgac aagatcctaa catacattgc    10080

tgccgatcac tgcccggtag tcgaggtgaa cggcgtgacc atccaagtcg ggagcaggag    10140

gtatccagac gctgtgtact tgcacagaat tgacctcggt cctcccatat cattggagag    10200

gttggacgta gggacaaatc tggggaatgc aattgctaag ttggaggatg ccaaggaatt    10260

gttggagtca tcggaccaga tattgaggag tatgaaaggt ttatcgagca ctagcatagt    10320

ctacatcctg attgcagtgt gtcttggagg gttgataggg atccccgctt taatatgttg    10380

ctgcaggggg cgttgtaaca aaaagggaga acaagttggt atgtcaagac caggcctaaa    10440

gcctgatctt acgggaacat caaaatccta tgtaaggtcg ctctgatcct ctacaactct    10500

tgaaacacaa atgtcccaca agtctcctct tcgtcatcaa gcaaccaccg cacccagcat    10560

caagcccacc tgaaattatc tccggcttcc ctctggccga acaatatcgg tagttaatca    10620

aaacttaggg tgcaagatca tccacaatgt caccacaacg agaccggata aatgccttct    10680

acaaagataa cccccatccc aagggaagta ggatagtcat taacagagaa catcttatga    10740

ttgatagacc ttatgttttg ctggctgttc tgtttgtcat gtttctgagc ttgatcgggt    10800

tgctagccat tgcaggcatt agacttcatc gggcagccat ctacaccgca gagatccata    10860

aaagcctcag caccaatcta gatgtaacta actcaatcga gcatcaggtc aaggacgtgc    10920

tgacaccact cttcaaaatc atcggtgatg aagtgggcct gaggacacct cagagattca    10980

ctgacctagt gaaattaatc tctgacaaga ttaaattcct taatccggat agggagtacg    11040

acttcagaga tctcacttgg tgtatcaacc cgccagagag aatcaaattg gattatgatc    11100

aatactgtgc agatgtggct gctgaagagc tcatgaatgc attggtgaac tcaactctac    11160

tggagaccag aacaaccaat cagttcctag ctgtctcaaa gggaaactgc tcagggccca    11220

ctacaatcag aggtcaattc tcaaacatgt cgctgtccct gttagacttg tatttaggtc    11280

gaggttacaa tgtgtcatct atagtcacta tgacatccca gggaatgtat gggggaactt    11340

acctagtgga aaagcctaat ctgagcagca aaaggtcaga gttgtcacaa ctgagcatgt    11400

accgagtgtt tgaagtaggt gttatcagaa atccgggttt gggggctccg gtgttccata    11460

tgacaaacta tcttgagcaa ccagtcagta atgatctcag caactgtatg gtggctttgg    11520

gggagctcaa actcgcagcc ctttgtcacg gggaagattc tatcacaatt ccctatcagg    11580

gatcagggaa aggtgtcagc ttccagctcg tcaagctagg tgtctggaaa tccccaaccg    11640

acatgcaatc ctgggtcccc ttatcaacgg atgatccagt gatagacagg ctttacctct    11700

catctcacag aggtgttatc gctgacaatc aagcaaaatg ggctgtcccg acaacacgaa    11760

cagatgacaa gttgcgaatg gagacatgct tccaacaggc gtgtaagggt aaaatccaag    11820

cactctgcga gaatcccgag tgggcaccat tgaaggataa caggattcct tcatacgggg    11880

tcttgtctgt tgatctgagt ctgacagttg agcttaaaat caaaattgct tcgggattcg    11940

ggccattgat cacacacggt tcagggatgg acctatacaa atccaaccac aacaatgtgt    12000

attggctgac tatcccgcca atgaagaacc tagccttagg tgtaatcaac acattggagt    12060

ggataccgag attcaaggtt agtccctacc tcttcactgt cccaattaag gaagcaggcg    12120

aagactgcca tgccccaaca tacctacctg cggaggtgga tggtgatgtc aaactcagtt    12180

ccaatctggt gattctacct ggtcaagatc tccaatatgt tttggcaacc tacgatactt    12240

ccagggttga acatgctgtg gtttattacg tttacagccc aagccgctca ttttcttact    12300

tttatccttt taggttgcct ataaaggggg tccccatcga attacaagtg gaatgcttca    12360

catgggacca aaaactctgg tgccgtcact tctgtgtgct tgcggactca gaatctggtg    12420

gacatatcac tcactctggg atggtgggca tgggagtcag ctgcacagtc acccgggaag    12480

atggaaccaa tcgcagatag ggctgctagt gaaccaatca catgatgtca cccagacatc    12540

aggcataccc actagtgtga aatagacatc agaattaaga aaaacgtagg gtccaagtgg    12600

ttccccgtta tggactcgct atctgtcaac cagatcttat accctgaagt tcacctagat    12660

agcccgatag ttaccaataa gatagtagcc atcctggagt atgctcgagt ccctcacgct    12720

tacagcctgg aggaccctac actgtgtcag aacatcaagc accgcctaaa aaacggattt    12780

tccaaccaaa tgattataaa caatgtggaa gttgggaatg tcatcaagtc caagcttagg    12840

agttatccgg cccactctca tattccatat ccaaattgta atcaggattt atttaacata    12900

gaagacaaag agtcaacgag gaagatccgt gaactcctca aaaaggggaa ttcgctgtac    12960

tccaaagtca gtgataaggt tttccaatgc ttaagggaca ctaactcacg gcttggccta    13020

ggctccgaat tgagggagga catcaaggag aaagttatta acttgggagt ttacatgcac    13080

agctcccagt ggtttgagcc ctttctgttt tggtttacag tcaagactga gatgaggtca    13140

gtgattaaat cacaaaccca tacttgccat aggaggagac acacacctgt attcttcact    13200

ggtagttcag ttgagttgct aatctctcgt gaccttgttg ctataatcag taaagagtct    13260

caacatgtat attacctgac atttgaactg gttttgatgt attgtgatgt catagagggg    13320

aggttaatga cagagaccgc tatgactatt gatgctaggt atacagagct tctaggaaga    13380

gtcagataca tgtggaaact gatagatggt ttcttccctg cactcgggaa tccaacttat    13440

caaattgtag ccatgctgga gcctctttca cttgcttacc tgcagctgag ggatataaca    13500

gtagaactca gaggtgcttt ccttaaccac tgctttactg aaatacatga tgttcttgac    13560

caaaacgggt tttctgatga aggtacttat catgagttaa ctgaagctct agattacatt    13620

ttcataactg atgacataca tctgacaggg gagattttct catttttcag aagtttcggc    13680

caccccagac ttgaagcagt aacggctgct gaaaatgtta ggaaatacat gaatcagcct    13740

aaagtcattg tgtatgagac tctgatgaaa ggtcatgcca tattttgtgg aatcataatc    13800

aacggctatc gtgacaggca cggaggcagt tggccaccgc tgaccctccc cctgcatgct    13860

gcagacacaa tccggaatgc tcaagcttca ggtgaagggt taacacatga gcagtgcgtt    13920

gataactgga aatcttttgc tggagtgaaa tttggctgct ttatgcctct tagcctggat    13980

agtgatctga caatgtacct aaaggacaag gcacttgctg ctctccaaag ggaatgggat    14040

tcagtttacc cgaaagagtt cctgcgttac gaccctccca agggaaccgg gtcacggagg    14100

cttgtagatg ttttccttaa tgattcgagc tttgacccat atgatgtgat aatgtatgtt    14160

gtaagtggag cttacctcca tgaccctgag ttcaacctgt cttacagcct gaaagaaaag    14220

gagatcaagg aaacaggtag actttttgct aaaatgactt acaaaatgag ggcatgccaa    14280

gtgattgctg aaaatctaat ctcaaacggg attggcaaat attttaagga caatgggatg    14340

gccaaggatg agcacgattt gactaaggca ctccacactc tagctgtctc aggagtcccc    14400

aaagatctca aagaaagtca cagggggggg ccagtcttaa aaacctactc ccgaagccca    14460

gtccacacaa gtaccaggaa cgtgagagca gcaaaagggt ttatagggtt ccctcaagta    14520

attcggcagg accaagacac tgatcatccg gagaatatgg aagcttacga gacagtcagt    14580

gcatttatca cgactgatct caagaagtac tgccttaatt ggagatatga gaccatcagc    14640

ttgtttgcac agaggctaaa tgagatttac ggattgccct catttttcca gtggctgcat    14700

aagaggcttg agacctctgt cctgtatgta agtgaccctc attgcccccc cgaccttgac    14760

gcccatatcc cgttatataa agtccccaat gatcaaatct tcattaagta ccctatggga    14820

ggtatagaag ggtattgtca gaagctgtgg accatcagca ccattcccta tctatacctg    14880

gctgcttatg agagcggagt aaggattgct tcgttagtgc aaggggacaa tcagaccata    14940

gccgtaacaa aaagggtacc cagcacatgg ccctacaacc ttaagaaacg ggaagctgct    15000

agagtaacta gagattactt tgtaattctt aggcaaaggc tacatgatat tggccatcac    15060

ctcaaggcaa atgagacaat tgtttcatca catttttttg tctattcaaa aggaatatat    15120

tatgatgggc tacttgtgtc ccaatcactc aagagcatcg caagatgtgt attctggtca    15180

gagactatag ttgatgaaac aagggcagca tgcagtaata ttgctacaac aatggctaaa    15240

agcatcgaga gaggttatga ccgttacctt gcatattccc tgaacgtcct aaaagtgata    15300

cagcaaattc tgatctctct tggcttcaca atcaattcaa ccatgacccg ggatgtagtc    15360

atacccctcc tcacaaacaa cgacctctta ataaggatgg cactgttgcc cgctcctatt    15420

ggggggatga attatctgaa tatgagcagg ctgtttgtca gaaacatcgg tgatccagta    15480

acatcatcaa ttgctgatct caagagaatg attctcgcct cactaatgcc tgaagagacc    15540

ctccatcaag taatgacaca acaaccgggg gactcttcat tcctagactg ggctagcgac    15600

ccttactcag caaatcttgt atgtgtccag agcatcacta gactcctcaa gaacataact    15660

gcaaggtttg tcctgatcca tagtccaaac ccaatgttaa aaggattatt ccatgatgac    15720

agtaaagaag aggacgaggg actggcggca ttcctcatgg acaggcatat tatagtacct    15780

agggcagctc atgaaatcct ggatcatagt gtcacagggg caagagagtc tattgcaggc    15840

atgctggata ccacaaaagg cttgattcga gccagcatga ggaagggggg gttaacctct    15900

cgagtgataa ccagattgtc caattatgac tatgaacaat tcagagcagg gatggtgcta    15960

ttgacaggaa gaaagagaaa tgtcctcatt gacaaagagt catgttcagt gcagctggcg    16020

agagctctaa gaagccatat gtgggcgagg ctagctcgag gacggcctat ttacggcctt    16080

gaggtccctg atgtactaga atctatgcga ggccacctta ttcggcgtca tgagacatgt    16140

gtcatctgcg agtgtggatc agtcaactac ggatggtttt ttgtcccctc gggttgccaa    16200

ctggatgata ttgacaagga aacatcatcc ttgagagtcc catatattgg ttctaccact    16260

gatgagagaa cagacatgaa gcttgccttc gtaagagccc caagtcgatc cttgcgatct    16320

gctgttagaa tagcaacagt gtactcatgg gcttacggtg atgatgatag ctcttggaac    16380

gaagcctggt tgttggctag gcaaagggcc aatgtgagcc tggaggagct aagggtgatc    16440

actcccatct caacttcgac taatttagcg cataggttga gggatcgtag cactcaagtg    16500

aaatactcag gtacatccct tgtccgagtg gcgaggtata ccacaatctc caacgacaat    16560

ctctcatttg tcatatcaga taagaaggtt gatactaact ttatatacca acaaggaatg    16620

cttctagggt tgggtgtttt agaaacattg tttcgactcg agaaagatac cggatcatct    16680

aacacggtat tacatcttca cgtcgaaaca gattgttgcg tgatcccgat gatagatcat    16740

cccaggatac ccagctcccg caagctagag ctgagggcag agctatgtac caacccattg    16800

atatatgata atgcaccttt aattgacaga gatgcaacaa ggctatacac ccagagccat    16860

aggaggcacc ttgtggaatt tgttacatgg tccacacccc aactatatca cattttagct    16920

aagtccacag cactatctat gattgacctg gtaacaaaat ttgagaagga ccatatgaat    16980

gaaatttcag ctctcatagg ggatgacgat atcaatagtt tcataactga gtttctgctc    17040

atagagccaa gattattcac tatctacttg ggccagtgtg cggccatcaa ttgggcattt    17100

gatgtacatt atcatagacc atcagggaaa tatcagatgg gtgagctgtt gtcatcgttc    17160

ctttctagaa tgagcaaagg agtgtttaag gtgcttgtca atgctctaag ccacccaaag    17220

atctacaaga aattctggca ttgtggtatt atagagccta tccatggtcc ttcacttgat    17280

gctcaaaact tgcacacaac tgtgtgcaac atggtttaca catgctatat gacctacctc    17340

gacctgttgt tgaatgaaga gttagaagag ttcacatttc tcttgtgtga aagcgacgag    17400

gatgtagtac cggacagatt cgacaacatc caggcaaaac acttatgtgt tctggcagat    17460

ttgtactgtc aaccagggac ctgcccacca attcgaggtc taagaccggt agagaaatgt    17520

gcagttctaa ccgaccatat caaggcagag gctatgttat ctccagcagg atcttcgtgg    17580

aacataaatc caattattgt agaccattac tcatgctctc tgacttatct ccggcgagga    17640

tcgatcaaac agataagatt gagagttgat ccaggattca ttttcgacgc cctcgctgag    17700

gtaaatgtca gtcagccaaa gatcggcagc aacaacatct caaatatgag catcaaggct    17760

ttcagacccc cacacgatga tgttgcaaaa ttgctcaaag atatcaacac aagcaagcac    17820

aatcttccca tttcaggggg caatctcgcc aattatgaaa tccatgcttt ccgcagaatc    17880

gggttgaact catctgcttg ctacaaagct gttgagatat caacattaat taggagatgc    17940

cttgagccag gggaggacgg cttgttcttg ggtgagggat cgggttctat gttgatcact    18000

tataaagaga tacttaaact aaacaagtgc ttctataata gtggggtttc cgccaattct    18060

agatctggtc aaagggaatt agcaccctat ccctccgaag ttggccttgt cgaacacaga    18120

atgggagtag gtaatattgt caaagtgctc tttaacggga ggcccgaagt cacgtgggta    18180

ggcagtgtag attgcttcaa tttcatagtt agtaatatcc ctacctctag tgtggggttt    18240

atccattcag atatagagac cttgcctgac aaagatacta tagagaagct agaggaattg    18300

gcagccatct tatcgatggc tctgctcctg ggcaaaatag gatcaatact ggtgattaag    18360

cttatgcctt tcagcgggga ttttgttcag ggatttataa gttatgtagg gtctcattat    18420

agagaagtga accttgtata ccctagatac agcaacttca tctctactga atcttatttg    18480

gttatgacag atctcaaggc taaccggcta atgaatcctg aaaagattaa gcagcagata    18540

attgaatcat ctgtgaggac ttcacctgga cttataggtc acatcctatc cattaagcaa    18600

ctaagctgca tacaagcaat tgtgggagac gcagttagta gaggtgatat caatcctact    18660

ctgaaaaaac ttacacctat agagcaggtg ctgatcaatt gcgggttggc aattaacgga    18720

cctaagctgt gcaaagaatt gatccaccat gatgttgcct cagggcaaga tggattgctt    18780

aattctatac tcatcctcta cagggagttg gcaagattca aagacaacca aagaagtcaa    18840

caagggatgt tccacgctta ccccgtattg gtaagtagca ggcaacgaga acttatatct    18900

aggatcaccc gcaaattctg ggggcacatt cttctttact ccgggaacaa aaagttgata    18960

aataagttta tccagaatct caagtccggc tatctgatac tagacttaca ccagaatatc    19020

ttcgttaaga atctatccaa gtcagagaaa cagattatta tgacgggggg tttgaaacgt    19080

gagtgggttt ttaaggtaac agtcaaggag accaaagaat ggtataagtt agtcggatac    19140

agtgccctga ttaaggacta attggttgaa ctccggaacc ctaatcctgc cctaggtggt    19200

taggcattat ttgcaatata ttaaagaaaa ctttgaaaat acgaagtttc tattcccagc    19260

tttgtctggt ggccggcatg gtcccagcct cctcgctggc gccggctggg caacattccg    19320

aggggaccgt cccctcggta atggcgaatg ggacgcggcc gatccggctg ctaacaaagc    19380

ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg    19440

ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggatgcgg    19500

ccgcgggccc tatggtaccc agcttttgtt ccctttagtg agggttaatt ccgagcttgg    19560

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca    19620

acataggagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg aggtaactca    19680

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc    19740

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt    19800

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact    19860

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag    19920

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata    19980

ggctcggccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc    20040

cgacaggact ataaagatac caggcgttcc cccctggaag ctccctcgtg cgctctcctg    20100

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc    20160

tttctcaatg ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg    20220

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc    20280

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga    20340

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg    20400

gctacactag aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa    20460

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg    20520

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt    20580

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat    20640

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct    20700

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta    20760

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actgcccgtc gtgtagataa    20820

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac    20880

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa    20940

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag    21000

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg    21060

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag    21120

ttacatgatc ccccatgttg tgaaaaaaag cggttagctc cttcggtcct ccgatcgttg    21180

tcagaagtaa gttggccgca gtgttatcac tcatgcttat ggcagcactg cataattctc    21240

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat    21300

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata    21360

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa    21420

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca    21480

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc    21540

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc    21600

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg    21660

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac    21720

ctgaaattgt aaacgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct    21780

cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa gaatagaccg    21840

agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag aacgtggact    21900

ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt gaaccatcac    21960

cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga    22020

gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga    22080

aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca    22140

ccacacccgc cgcgcttaat gcgccgctac agggcgcgtc ccattcgcca ttcaggctgc    22200

gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag ccaccgcggt    22260

g                                                                    22261


<210>  143
<211>  22363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete optimised nucleotide sequence of the polynucleotide 
       encoding pTM-MVDVax10


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  NotI

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammerhead ribozyme

<220>
<221>  misc_feature
<222>  (83)..(189)
<223>  MV Leader and N promoter

<220>
<221>  misc_feature
<222>  (190)..(1767)
<223>  MV N ORF

<220>
<221>  misc_feature
<222>  (1768)..(1888)
<223>  MV N-P intergenic

<220>
<221>  misc_feature
<222>  (1889)..(3412)
<223>  MV P ORF

<220>
<221>  misc_feature
<222>  (3413)..(3531)
<223>  MV ATU2

<220>
<221>  misc_feature
<222>  (3532)..(5154)
<223>  DENV1 NS polyepitope

<220>
<221>  misc_feature
<222>  (5155)..(5253)
<223>  MV P-M intergenic

<220>
<221>  misc_feature
<222>  (5254)..(6261)
<223>  MV M ORF

<220>
<221>  misc_feature
<222>  (6262)..(7264)
<223>  MV M-F intergenic

<220>
<221>  misc_feature
<222>  (7265)..(8926)
<223>  MV F ORF

<220>
<221>  misc_feature
<222>  (8927)..(9086)
<223>  MV-F-H intergenic

<220>
<221>  misc_feature
<222>  (9087)..(10940)
<223>  MV H ORF

<220>
<221>  misc_feature
<222>  (10941)..(11067)
<223>  MV ATU3

<220>
<221>  misc_feature
<222>  (11068)..(12618)
<223>  DENV tetra EDIII + ectoM

<220>
<221>  misc_feature
<222>  (12619)..(12711)
<223>  MV H-L intergenic

<220>
<221>  misc_feature
<222>  (12712)..(19263)
<223>  MV L ORF

<220>
<221>  misc_feature
<222>  (19264)..(19372)
<223>  MV Trailer

<220>
<221>  misc_feature
<222>  (19373)..(19456)
<223>  HDV ribozyme

<220>
<221>  misc_feature
<222>  (19457)..(19598)
<223>  T7 terminator

<220>
<221>  misc_feature
<222>  (19599)..(19606)
<223>  Not I

<220>
<221>  misc_feature
<222>  (19607)..(122363)
<223>  pTM plasmid

<400>  143
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagc ctaccctcca tcattgttat     3480

aaaaaactta ggaaccaggt ccacacagcc gccagcccat caacgcgtac gatggcatca     3540

caggagggac cactgcccga aattgaggac gaagtgttta gaaagcgaaa tctgactatt     3600

atggacctgc accccggatc tggcaagacc cggagatacc tgccagccat cgtgagggag     3660

gctattaagc ggaaactgag aacactgatc ctggccccaa ctcgcgtggt cgcttccgaa     3720

atggctgagg ccctgaaagg catgcccatc cggtatcaga ccacagcagt gaagtctgaa     3780

cataccggca aggagattgt ggacctgatg tgccacgcca ctttcaccat gcgactgctg     3840

agcccagtgc gggtccccaa ctacaatatg atcattatgg acgaggccca ctttactgat     3900

cccagctcca tcgccgctag aggatatatt tccaccaggg tgggaatggg cgaggcagca     3960

gctatcttca tgacagcaac tccccctggc agcgtggagg catttcctca gtccaacgcc     4020

gtcatccagg acgaggagcg ggacattcct gagcggagct ggaattctgg gtacgaatgg     4080

atcacagacg aggatcatgc acactggact gaagccaaga tgctgctgga caacattaat     4140

actcctgagg gaatcattcc agctctgttc gagcccgaaa gagagaagtc tgcagccatc     4200

gacggcgagt atagactgag gggagaggcc cggaagacct tcgtggaact gatgaggcgc     4260

ggcgatctgc ccgtgtggct gagttacaag gtcgcttcag agggattcca gtatagtgac     4320

cgacggtggt gctttgatgg cgaacgcaac aatcaggtgc tggaggagaa catggatgtc     4380

gagatttgga caaaggaagg cgagcggaag aaactgcgcc cacgatggct ggacgctcgg     4440

acttacagcg atcccctggc actgagagaa ttcaaagagt ttgctgcagg ggtggccgtc     4500

gagaatcacc atcacgccgc tatgctggac gtggatctgc atcctgccag tgcttggacc     4560

ctgtatgcag tggccactac catcattacc ccaatgatgc gccacacaat cgagaacaca     4620

actgccaata tctcactgac agctattgca aaccaggcag ccattctgat gggactggac     4680

aaaggctggc ccatcagcaa gatggatatt ggcgtgcctc tgctggccct ggggtgttac     4740

agtcaggtgc tggacatcat tggccagagg atcgagaaca ttaagcatga gcacaaatca     4800

acctggcatt acgacgaaga taatccctat aagacatggg cctaccacgg aagctatgag     4860

gtgaaacctt caggcagcgc cagcagcatg gtcaacgggg tggtcaagct gctgaccaaa     4920

ccttgggacg tgatcccaat ggtcactcag attgccatga ccgataccac cccattcggc     4980

cagcagcggg tgttcaagga gaaggtggac acccgcacac ctaaggctaa acgagggact     5040

gcacagatca tggaggtgac cgccaagtgg ctgtggggat tcctgtccag gaacaagaag     5100

ccaagaatct gtaccaggga agagttcaca agaaaggtcc ggtcaaacgc ctaatgagcg     5160

cgcagcgctt agacgtctcg cgatcgatac tagtacaacc taaatccatt ataaaaaact     5220

taggagcaaa gtgattgcct cccaaggtcc acaatgacag agacctacga cttcgacaag     5280

tcggcatggg acatcaaagg gtcgatcgct ccgatacaac ccaccaccta cagtgatggc     5340

aggctggtgc cccaggtcag agtcatagat cctggtctag gcgacaggaa ggatgaatgc     5400

tttatgtaca tgtttctgct gggggttgtt gaggacagcg attccctagg gcctccaatc     5460

gggcgagcat ttgggttcct gcccttaggt gttggcagat ccacagcaaa gcccgaaaaa     5520

ctcctcaaag aggccactga gcttgacata gttgttagac gtacagcagg gctcaatgaa     5580

aaactggtgt tctacaacaa caccccacta actctcctca caccttggag aaaggtccta     5640

acaacaggga gtgtcttcaa cgcaaaccaa gtgtgcaatg cggttaatct gataccgctc     5700

gataccccgc agaggttccg tgttgtttat atgagcatca cccgtctttc ggataacggg     5760

tattacaccg ttcctagaag aatgctggaa ttcagatcgg tcaatgcagt ggccttcaac     5820

ctgctggtga cccttaggat tgacaaggcg ataggccctg ggaagatcat cgacaataca     5880

gagcaacttc ctgaggcaac atttatggtc cacatcggga acttcaggag aaagaagagt     5940

gaagtctact ctgccgatta ttgcaaaatg aaaatcgaaa agatgggcct ggtttttgca     6000

cttggtggga tagggggcac cagtcttcac attagaagca caggcaaaat gagcaagact     6060

ctccatgcac aactcgggtt caagaagacc ttatgttacc cgctgatgga tatcaatgaa     6120

gaccttaatc gattactctg gaggagcaga tgcaagatag taagaatcca ggcagttttg     6180

cagccatcag ttcctcaaga attccgcatt tacgacgacg tgatcataaa tgatgaccaa     6240

ggactattca aagttctgta gaccgtagtg cccagcaatg cccgaaaacg acccccctca     6300

caatgacagc cagaaggccc ggacaaaaaa gccccctccg aaagactcca cggaccaagc     6360

gagaggccag ccagcagccg acggcaagcg cgaacaccag gcggccccag cacagaacag     6420

ccctgacaca aggccaccac cagccacccc aatctgcatc ctcctcgtgg gacccccgag     6480

gaccaacccc caaggctgcc cccgatccaa accaccaacc gcatccccac cacccccggg     6540

aaagaaaccc ccagcaattg gaaggcccct ccccctcttc ctcaacacaa gaactccaca     6600

accgaaccgc acaagcgacc gaggtgaccc aaccgcaggc atccgactcc ctagacagat     6660

cctctctccc cggcaaacta aacaaaactt agggccaagg aacatacaca cccaacagaa     6720

cccagacccc ggcccacggc gccgcgcccc caacccccga caaccagagg gagcccccaa     6780

ccaatcccgc cggctccccc ggtgcccaca ggcagggaca ccaacccccg aacagaccca     6840

gcacccaacc atcgacaatc caagacgggg gggccccccc aaaaaaaggc ccccaggggc     6900

cgacagccag caccgcgagg aagcccaccc accccacaca cgaccacggc aaccaaacca     6960

gaacccagac caccctgggc caccagctcc cagactcggc catcaccccg cagaaaggaa     7020

aggccacaac ccgcgcaccc cagccccgat ccggcgggga gccacccaac ccgaaccagc     7080

acccaagagc gatccccgaa ggacccccga accgcaaagg acatcagtat cccacagcct     7140

ctccaagtcc cccggtctcc tcctcttctc gaagggacca aaagatcaat ccaccacacc     7200

cgacgacact caactcccca cccctaaagg agacaccggg aatcccagaa tcaagactca     7260

tccaatgtcc atcatgggtc tcaaggtgaa cgtctctgcc atattcatgg cagtactgtt     7320

aactctccaa acacccaccg gtcaaatcca ttggggcaat ctctctaaga taggggtggt     7380

aggaatagga agtgcaagct acaaagttat gactcgttcc agccatcaat cattagtcat     7440

aaaattaatg cccaatataa ctctcctcaa taactgcacg agggtagaga ttgcagaata     7500

caggagacta ctgagaacag ttttggaacc aattagagat gcacttaatg caatgaccca     7560

gaatataaga ccggttcaga gtgtagcttc aagtaggaga cacaagagat ttgcgggagt     7620

agtcctggca ggtgcggccc taggcgttgc cacagctgct cagataacag ccggcattgc     7680

acttcaccag tccatgctga actctcaagc catcgacaat ctgagagcga gcctggaaac     7740

tactaatcag gcaattgaga caatcagaca agcagggcag gagatgatat tggctgttca     7800

gggtgtccaa gactacatca ataatgagct gataccgtct atgaaccaac tatcttgtga     7860

tttaatcggc cagaagctcg ggctcaaatt gctcagatac tatacagaaa tcctgtcatt     7920

atttggcccc agtttacggg accccatatc tgcggagata tctatccagg ctttgagcta     7980

tgcgcttgga ggagacatca ataaggtgtt agaaaagctc ggatacagtg gaggtgattt     8040

actgggcatc ttagagagcg gaggaataaa ggcccggata actcacgtcg acacagagtc     8100

ctacttcatt gtcctcagta tagcctatcc gacgctgtcc gagattaagg gggtgattgt     8160

ccaccggcta gagggggtct cgtacaacat aggctctcaa gagtggtata ccactgtgcc     8220

caagtatgtt gcaacccaag ggtaccttat ctcgaatttt gatgagtcat cgtgtacttt     8280

catgccagag gggactgtgt gcagccaaaa tgccttgtac ccgatgagtc ctctgctcca     8340

agaatgcctc cgggggtaca ccaagtcctg tgctcgtaca ctcgtatccg ggtcttttgg     8400

gaaccggttc attttatcac aagggaacct aatagccaat tgtgcatcaa tcctttgcaa     8460

gtgttacaca acaggaacga tcattaatca agaccctgac aagatcctaa catacattgc     8520

tgccgatcac tgcccggtag tcgaggtgaa cggcgtgacc atccaagtcg ggagcaggag     8580

gtatccagac gctgtgtact tgcacagaat tgacctcggt cctcccatat cattggagag     8640

gttggacgta gggacaaatc tggggaatgc aattgctaag ttggaggatg ccaaggaatt     8700

gttggagtca tcggaccaga tattgaggag tatgaaaggt ttatcgagca ctagcatagt     8760

ctacatcctg attgcagtgt gtcttggagg gttgataggg atccccgctt taatatgttg     8820

ctgcaggggg cgttgtaaca aaaagggaga acaagttggt atgtcaagac caggcctaaa     8880

gcctgatctt acgggaacat caaaatccta tgtaaggtcg ctctgatcct ctacaactct     8940

tgaaacacaa atgtcccaca agtctcctct tcgtcatcaa gcaaccaccg cacccagcat     9000

caagcccacc tgaaattatc tccggcttcc ctctggccga acaatatcgg tagttaatca     9060

aaacttaggg tgcaagatca tccacaatgt caccacaacg agaccggata aatgccttct     9120

acaaagataa cccccatccc aagggaagta ggatagtcat taacagagaa catcttatga     9180

ttgatagacc ttatgttttg ctggctgttc tgtttgtcat gtttctgagc ttgatcgggt     9240

tgctagccat tgcaggcatt agacttcatc gggcagccat ctacaccgca gagatccata     9300

aaagcctcag caccaatcta gatgtaacta actcaatcga gcatcaggtc aaggacgtgc     9360

tgacaccact cttcaaaatc atcggtgatg aagtgggcct gaggacacct cagagattca     9420

ctgacctagt gaaattaatc tctgacaaga ttaaattcct taatccggat agggagtacg     9480

acttcagaga tctcacttgg tgtatcaacc cgccagagag aatcaaattg gattatgatc     9540

aatactgtgc agatgtggct gctgaagagc tcatgaatgc attggtgaac tcaactctac     9600

tggagaccag aacaaccaat cagttcctag ctgtctcaaa gggaaactgc tcagggccca     9660

ctacaatcag aggtcaattc tcaaacatgt cgctgtccct gttagacttg tatttaggtc     9720

gaggttacaa tgtgtcatct atagtcacta tgacatccca gggaatgtat gggggaactt     9780

acctagtgga aaagcctaat ctgagcagca aaaggtcaga gttgtcacaa ctgagcatgt     9840

accgagtgtt tgaagtaggt gttatcagaa atccgggttt gggggctccg gtgttccata     9900

tgacaaacta tcttgagcaa ccagtcagta atgatctcag caactgtatg gtggctttgg     9960

gggagctcaa actcgcagcc ctttgtcacg gggaagattc tatcacaatt ccctatcagg    10020

gatcagggaa aggtgtcagc ttccagctcg tcaagctagg tgtctggaaa tccccaaccg    10080

acatgcaatc ctgggtcccc ttatcaacgg atgatccagt gatagacagg ctttacctct    10140

catctcacag aggtgttatc gctgacaatc aagcaaaatg ggctgtcccg acaacacgaa    10200

cagatgacaa gttgcgaatg gagacatgct tccaacaggc gtgtaagggt aaaatccaag    10260

cactctgcga gaatcccgag tgggcaccat tgaaggataa caggattcct tcatacgggg    10320

tcttgtctgt tgatctgagt ctgacagttg agcttaaaat caaaattgct tcgggattcg    10380

ggccattgat cacacacggt tcagggatgg acctatacaa atccaaccac aacaatgtgt    10440

attggctgac tatcccgcca atgaagaacc tagccttagg tgtaatcaac acattggagt    10500

ggataccgag attcaaggtt agtccctacc tcttcactgt cccaattaag gaagcaggcg    10560

aagactgcca tgccccaaca tacctacctg cggaggtgga tggtgatgtc aaactcagtt    10620

ccaatctggt gattctacct ggtcaagatc tccaatatgt tttggcaacc tacgatactt    10680

ccagggttga acatgctgtg gtttattacg tttacagccc aagccgctca ttttcttact    10740

tttatccttt taggttgcct ataaaggggg tccccatcga attacaagtg gaatgcttca    10800

catgggacca aaaactctgg tgccgtcact tctgtgtgct tgcggactca gaatctggtg    10860

gacatatcac tcactctggg atggtgggca tgggagtcag ctgcacagtc acccgggaag    10920

atggaaccaa tcgcagatag ggctgctagt gaaccaatca catgatgtca cccagacatc    10980

aggcataccc actagtctac cctccatcat tgttataaaa aacttaggaa ccaggtccac    11040

acagccgcca gcccatcaac gcgtacgatg ggcatcatat tcattcttct tatgctggtt    11100

acaccgtcta tggcggagaa acttcgaatc aaaggtatga gctatacgat gtgcagcggc    11160

aagttcaaga tcgagaagga aatggctgaa acccagcacg gtacaactgt ggtcaaagtc    11220

aaatatgagg gggctggcgc tccctgtaaa gtacccattg agattaggga cgtcaataaa    11280

gagaaggtgg taggtcgcat catctccagt acacctttgg ccgagaacac gaactccgtc    11340

acaaacatag agttggaacc cccgttcgga gactcataca ttgtgatcgg ggtgggcaac    11400

tctgcactca cactgcattg gttcaagaag ggaagcagta tcggccgcag ggataagaga    11460

gacaaactga aattgaaagg tatgtcctat gccatgtgca cgaatacttt cgttctcaag    11520

aaagaagtat ctgagactca gcacggaacc atcctgatca aagtcgagta caaaggagaa    11580

gacgtgccct gtaagatccc attcagtacc gaggatggac agggcaaggc ccataacggc    11640

aggctgataa ccgccaaccc tgtggttaca aagaaggaag agccagtcaa tatcgaagct    11700

gagccaccgt tcggggagag caacatagta attggcatag gggataatgc tttgaagatc    11760

aactggtaca agaaaggaag ctccattggc cgaagagata agcgcgacaa actccagctg    11820

aaaggaatga gctactccat gtgtactggg aagttcaaga ttgtcaagga aatcgccgaa    11880

actcagcatg gcactattgt gatccgcgtg cagtatgaag gcgatggtag cccctgcaag    11940

ataccatttg aaatcaccga tttggagaaa cggcacgtcc tgggtcggct cattaccgtg    12000

aacccaatcg tgaccgagaa ggacagtcca gttaatatcg aggccgagcc tcctttcggc    12060

gacagttaca tcattgtagg ggtggaacca gggcaactga agctgaactg gttcaagaaa    12120

ggcagcagta taggacggcg ggataaacgg gacaaactca cactgaaagg catgtcatac    12180

gttatgtgca ccggctcatt caaactggag aaggaagttg cagagacaca gcatgggacc    12240

gtgctcgtgc aggtcaaata cgagggcacc gacgctcctt gcaagattcc gttcagtaca    12300

caggacgaga aaggcgtgac tcagaacggc agattgatta cagcgaaccc tatcgtgact    12360

gacaaggaga agccagttaa catcgagact gagccgcctt tcggagaatc atacattatc    12420

gtgggagccg gcgagaaggc actgaaactc agctggttca agaagggcag ctcaatcggt    12480

cggagagaca agcggtctgt cgccctcgca ccgcacgtgg gcctgggtct ggaaacgagg    12540

accgagacgt ggatgagttc cgaaggcgca tggaagcaaa tccagaaagt ggagacgtgg    12600

gccctcaggc atccgtaatg agcgcgcagc gcttagacgt ctcgcgatcg atgctagtgt    12660

gaaatagaca tcagaattaa gaaaaacgta gggtccaagt ggttccccgt tatggactcg    12720

ctatctgtca accagatctt ataccctgaa gttcacctag atagcccgat agttaccaat    12780

aagatagtag ccatcctgga gtatgctcga gtccctcacg cttacagcct ggaggaccct    12840

acactgtgtc agaacatcaa gcaccgccta aaaaacggat tttccaacca aatgattata    12900

aacaatgtgg aagttgggaa tgtcatcaag tccaagctta ggagttatcc ggcccactct    12960

catattccat atccaaattg taatcaggat ttatttaaca tagaagacaa agagtcaacg    13020

aggaagatcc gtgaactcct caaaaagggg aattcgctgt actccaaagt cagtgataag    13080

gttttccaat gcttaaggga cactaactca cggcttggcc taggctccga attgagggag    13140

gacatcaagg agaaagttat taacttggga gtttacatgc acagctccca gtggtttgag    13200

ccctttctgt tttggtttac agtcaagact gagatgaggt cagtgattaa atcacaaacc    13260

catacttgcc ataggaggag acacacacct gtattcttca ctggtagttc agttgagttg    13320

ctaatctctc gtgaccttgt tgctataatc agtaaagagt ctcaacatgt atattacctg    13380

acatttgaac tggttttgat gtattgtgat gtcatagagg ggaggttaat gacagagacc    13440

gctatgacta ttgatgctag gtatacagag cttctaggaa gagtcagata catgtggaaa    13500

ctgatagatg gtttcttccc tgcactcggg aatccaactt atcaaattgt agccatgctg    13560

gagcctcttt cacttgctta cctgcagctg agggatataa cagtagaact cagaggtgct    13620

ttccttaacc actgctttac tgaaatacat gatgttcttg accaaaacgg gttttctgat    13680

gaaggtactt atcatgagtt aactgaagct ctagattaca ttttcataac tgatgacata    13740

catctgacag gggagatttt ctcatttttc agaagtttcg gccaccccag acttgaagca    13800

gtaacggctg ctgaaaatgt taggaaatac atgaatcagc ctaaagtcat tgtgtatgag    13860

actctgatga aaggtcatgc catattttgt ggaatcataa tcaacggcta tcgtgacagg    13920

cacggaggca gttggccacc gctgaccctc cccctgcatg ctgcagacac aatccggaat    13980

gctcaagctt caggtgaagg gttaacacat gagcagtgcg ttgataactg gaaatctttt    14040

gctggagtga aatttggctg ctttatgcct cttagcctgg atagtgatct gacaatgtac    14100

ctaaaggaca aggcacttgc tgctctccaa agggaatggg attcagttta cccgaaagag    14160

ttcctgcgtt acgaccctcc caagggaacc gggtcacgga ggcttgtaga tgttttcctt    14220

aatgattcga gctttgaccc atatgatgtg ataatgtatg ttgtaagtgg agcttacctc    14280

catgaccctg agttcaacct gtcttacagc ctgaaagaaa aggagatcaa ggaaacaggt    14340

agactttttg ctaaaatgac ttacaaaatg agggcatgcc aagtgattgc tgaaaatcta    14400

atctcaaacg ggattggcaa atattttaag gacaatggga tggccaagga tgagcacgat    14460

ttgactaagg cactccacac tctagctgtc tcaggagtcc ccaaagatct caaagaaagt    14520

cacagggggg ggccagtctt aaaaacctac tcccgaagcc cagtccacac aagtaccagg    14580

aacgtgagag cagcaaaagg gtttataggg ttccctcaag taattcggca ggaccaagac    14640

actgatcatc cggagaatat ggaagcttac gagacagtca gtgcatttat cacgactgat    14700

ctcaagaagt actgccttaa ttggagatat gagaccatca gcttgtttgc acagaggcta    14760

aatgagattt acggattgcc ctcatttttc cagtggctgc ataagaggct tgagacctct    14820

gtcctgtatg taagtgaccc tcattgcccc cccgaccttg acgcccatat cccgttatat    14880

aaagtcccca atgatcaaat cttcattaag taccctatgg gaggtataga agggtattgt    14940

cagaagctgt ggaccatcag caccattccc tatctatacc tggctgctta tgagagcgga    15000

gtaaggattg cttcgttagt gcaaggggac aatcagacca tagccgtaac aaaaagggta    15060

cccagcacat ggccctacaa ccttaagaaa cgggaagctg ctagagtaac tagagattac    15120

tttgtaattc ttaggcaaag gctacatgat attggccatc acctcaaggc aaatgagaca    15180

attgtttcat cacatttttt tgtctattca aaaggaatat attatgatgg gctacttgtg    15240

tcccaatcac tcaagagcat cgcaagatgt gtattctggt cagagactat agttgatgaa    15300

acaagggcag catgcagtaa tattgctaca acaatggcta aaagcatcga gagaggttat    15360

gaccgttacc ttgcatattc cctgaacgtc ctaaaagtga tacagcaaat tctgatctct    15420

cttggcttca caatcaattc aaccatgacc cgggatgtag tcatacccct cctcacaaac    15480

aacgacctct taataaggat ggcactgttg cccgctccta ttggggggat gaattatctg    15540

aatatgagca ggctgtttgt cagaaacatc ggtgatccag taacatcatc aattgctgat    15600

ctcaagagaa tgattctcgc ctcactaatg cctgaagaga ccctccatca agtaatgaca    15660

caacaaccgg gggactcttc attcctagac tgggctagcg acccttactc agcaaatctt    15720

gtatgtgtcc agagcatcac tagactcctc aagaacataa ctgcaaggtt tgtcctgatc    15780

catagtccaa acccaatgtt aaaaggatta ttccatgatg acagtaaaga agaggacgag    15840

ggactggcgg cattcctcat ggacaggcat attatagtac ctagggcagc tcatgaaatc    15900

ctggatcata gtgtcacagg ggcaagagag tctattgcag gcatgctgga taccacaaaa    15960

ggcttgattc gagccagcat gaggaagggg gggttaacct ctcgagtgat aaccagattg    16020

tccaattatg actatgaaca attcagagca gggatggtgc tattgacagg aagaaagaga    16080

aatgtcctca ttgacaaaga gtcatgttca gtgcagctgg cgagagctct aagaagccat    16140

atgtgggcga ggctagctcg aggacggcct atttacggcc ttgaggtccc tgatgtacta    16200

gaatctatgc gaggccacct tattcggcgt catgagacat gtgtcatctg cgagtgtgga    16260

tcagtcaact acggatggtt ttttgtcccc tcgggttgcc aactggatga tattgacaag    16320

gaaacatcat ccttgagagt cccatatatt ggttctacca ctgatgagag aacagacatg    16380

aagcttgcct tcgtaagagc cccaagtcga tccttgcgat ctgctgttag aatagcaaca    16440

gtgtactcat gggcttacgg tgatgatgat agctcttgga acgaagcctg gttgttggct    16500

aggcaaaggg ccaatgtgag cctggaggag ctaagggtga tcactcccat ctcaacttcg    16560

actaatttag cgcataggtt gagggatcgt agcactcaag tgaaatactc aggtacatcc    16620

cttgtccgag tggcgaggta taccacaatc tccaacgaca atctctcatt tgtcatatca    16680

gataagaagg ttgatactaa ctttatatac caacaaggaa tgcttctagg gttgggtgtt    16740

ttagaaacat tgtttcgact cgagaaagat accggatcat ctaacacggt attacatctt    16800

cacgtcgaaa cagattgttg cgtgatcccg atgatagatc atcccaggat acccagctcc    16860

cgcaagctag agctgagggc agagctatgt accaacccat tgatatatga taatgcacct    16920

ttaattgaca gagatgcaac aaggctatac acccagagcc ataggaggca ccttgtggaa    16980

tttgttacat ggtccacacc ccaactatat cacattttag ctaagtccac agcactatct    17040

atgattgacc tggtaacaaa atttgagaag gaccatatga atgaaatttc agctctcata    17100

ggggatgacg atatcaatag tttcataact gagtttctgc tcatagagcc aagattattc    17160

actatctact tgggccagtg tgcggccatc aattgggcat ttgatgtaca ttatcataga    17220

ccatcaggga aatatcagat gggtgagctg ttgtcatcgt tcctttctag aatgagcaaa    17280

ggagtgttta aggtgcttgt caatgctcta agccacccaa agatctacaa gaaattctgg    17340

cattgtggta ttatagagcc tatccatggt ccttcacttg atgctcaaaa cttgcacaca    17400

actgtgtgca acatggttta cacatgctat atgacctacc tcgacctgtt gttgaatgaa    17460

gagttagaag agttcacatt tctcttgtgt gaaagcgacg aggatgtagt accggacaga    17520

ttcgacaaca tccaggcaaa acacttatgt gttctggcag atttgtactg tcaaccaggg    17580

acctgcccac caattcgagg tctaagaccg gtagagaaat gtgcagttct aaccgaccat    17640

atcaaggcag aggctatgtt atctccagca ggatcttcgt ggaacataaa tccaattatt    17700

gtagaccatt actcatgctc tctgacttat ctccggcgag gatcgatcaa acagataaga    17760

ttgagagttg atccaggatt cattttcgac gccctcgctg aggtaaatgt cagtcagcca    17820

aagatcggca gcaacaacat ctcaaatatg agcatcaagg ctttcagacc cccacacgat    17880

gatgttgcaa aattgctcaa agatatcaac acaagcaagc acaatcttcc catttcaggg    17940

ggcaatctcg ccaattatga aatccatgct ttccgcagaa tcgggttgaa ctcatctgct    18000

tgctacaaag ctgttgagat atcaacatta attaggagat gccttgagcc aggggaggac    18060

ggcttgttct tgggtgaggg atcgggttct atgttgatca cttataaaga gatacttaaa    18120

ctaaacaagt gcttctataa tagtggggtt tccgccaatt ctagatctgg tcaaagggaa    18180

ttagcaccct atccctccga agttggcctt gtcgaacaca gaatgggagt aggtaatatt    18240

gtcaaagtgc tctttaacgg gaggcccgaa gtcacgtggg taggcagtgt agattgcttc    18300

aatttcatag ttagtaatat ccctacctct agtgtggggt ttatccattc agatatagag    18360

accttgcctg acaaagatac tatagagaag ctagaggaat tggcagccat cttatcgatg    18420

gctctgctcc tgggcaaaat aggatcaata ctggtgatta agcttatgcc tttcagcggg    18480

gattttgttc agggatttat aagttatgta gggtctcatt atagagaagt gaaccttgta    18540

taccctagat acagcaactt catctctact gaatcttatt tggttatgac agatctcaag    18600

gctaaccggc taatgaatcc tgaaaagatt aagcagcaga taattgaatc atctgtgagg    18660

acttcacctg gacttatagg tcacatccta tccattaagc aactaagctg catacaagca    18720

attgtgggag acgcagttag tagaggtgat atcaatccta ctctgaaaaa acttacacct    18780

atagagcagg tgctgatcaa ttgcgggttg gcaattaacg gacctaagct gtgcaaagaa    18840

ttgatccacc atgatgttgc ctcagggcaa gatggattgc ttaattctat actcatcctc    18900

tacagggagt tggcaagatt caaagacaac caaagaagtc aacaagggat gttccacgct    18960

taccccgtat tggtaagtag caggcaacga gaacttatat ctaggatcac ccgcaaattc    19020

tgggggcaca ttcttcttta ctccgggaac aaaaagttga taaataagtt tatccagaat    19080

ctcaagtccg gctatctgat actagactta caccagaata tcttcgttaa gaatctatcc    19140

aagtcagaga aacagattat tatgacgggg ggtttgaaac gtgagtgggt ttttaaggta    19200

acagtcaagg agaccaaaga atggtataag ttagtcggat acagtgccct gattaaggac    19260

taattggttg aactccggaa ccctaatcct gccctaggtg gttaggcatt atttgcaata    19320

tattaaagaa aactttgaaa atacgaagtt tctattccca gctttgtctg gtggccggca    19380

tggtcccagc ctcctcgctg gcgccggctg ggcaacattc cgaggggacc gtcccctcgg    19440

taatggcgaa tgggacgcgg ccgatccggc tgctaacaaa gcccgaaagg aagctgagtt    19500

ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt    19560

gaggggtttt ttgctgaaag gaggaactat atccggatgc ggccgcgggc cctatggtac    19620

ccagcttttg ttccctttag tgagggttaa ttccgagctt ggcgtaatca tggtcatagc    19680

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatagga gccggaagca    19740

taaagtgtaa agcctggggt gcctaatgag tgaggtaact cacattaatt gcgttgcgct    19800

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac    19860

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc    19920

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt    19980

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg    20040

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctcggc ccccctgacg    20100

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat    20160

accaggcgtt cccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta    20220

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct    20280

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc    20340

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa    20400

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg    20460

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag    20520

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt    20580

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta    20640

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc    20700

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca    20760

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa    20820

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat    20880

ttcgttcatc catagttgcc tgactgcccg tcgtgtagat aactacgata cgggagggct    20940

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt    21000

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat    21060

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta    21120

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg    21180

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt    21240

tgtgaaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg    21300

cagtgttatc actcatgctt atggcagcac tgcataattc tcttactgtc atgccatccg    21360

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc    21420

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa    21480

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac    21540

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt    21600

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg    21660

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa    21720

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata    21780

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgaaatt gtaaacgtta    21840

atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg    21900

ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg    21960

ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa    22020

aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg    22080

ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt    22140

gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg    22200

ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta    22260

atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt tgggaagggc    22320

gatcggtgcg ggcctcttcg ctattacgcc agccaccgcg gtg                      22363


<210>  144
<211>  1554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the polynucleotide encoding DENV tetra 
       EDIII-ectoM

<400>  144
atgggcatca tattcattct tcttatgctg gttacaccgt ctatggcgga gaaacttcga       60

atcaaaggta tgagctatac gatgtgcagc ggcaagttca agatcgagaa ggaaatggct      120

gaaacccagc acggtacaac tgtggtcaaa gtcaaatatg agggggctgg cgctccctgt      180

aaagtaccca ttgagattag ggacgtcaat aaagagaagg tggtaggtcg catcatctcc      240

agtacacctt tggccgagaa cacgaactcc gtcacaaaca tagagttgga acccccgttc      300

ggagactcat acattgtgat cggggtgggc aactctgcac tcacactgca ttggttcaag      360

aagggaagca gtatcggccg cagggataag agagacaaac tgaaattgaa aggtatgtcc      420

tatgccatgt gcacgaatac tttcgttctc aagaaagaag tatctgagac tcagcacgga      480

accatcctga tcaaagtcga gtacaaagga gaagacgtgc cctgtaagat cccattcagt      540

accgaggatg gacagggcaa ggcccataac ggcaggctga taaccgccaa ccctgtggtt      600

acaaagaagg aagagccagt caatatcgaa gctgagccac cgttcgggga gagcaacata      660

gtaattggca taggggataa tgctttgaag atcaactggt acaagaaagg aagctccatt      720

ggccgaagag ataagcgcga caaactccag ctgaaaggaa tgagctactc catgtgtact      780

gggaagttca agattgtcaa ggaaatcgcc gaaactcagc atggcactat tgtgatccgc      840

gtgcagtatg aaggcgatgg tagcccctgc aagataccat ttgaaatcac cgatttggag      900

aaacggcacg tcctgggtcg gctcattacc gtgaacccaa tcgtgaccga gaaggacagt      960

ccagttaata tcgaggccga gcctcctttc ggcgacagtt acatcattgt aggggtggaa     1020

ccagggcaac tgaagctgaa ctggttcaag aaaggcagca gtataggacg gcgggataaa     1080

cgggacaaac tcacactgaa aggcatgtca tacgttatgt gcaccggctc attcaaactg     1140

gagaaggaag ttgcagagac acagcatggg accgtgctcg tgcaggtcaa atacgagggc     1200

accgacgctc cttgcaagat tccgttcagt acacaggacg agaaaggcgt gactcagaac     1260

ggcagattga ttacagcgaa ccctatcgtg actgacaagg agaagccagt taacatcgag     1320

actgagccgc ctttcggaga atcatacatt atcgtgggag ccggcgagaa ggcactgaaa     1380

ctcagctggt tcaagaaggg cagctcaatc ggtcggagag acaagcggtc tgtcgccctc     1440

gcaccgcacg tgggcctggg tctggaaacg aggaccgaga cgtggatgag ttccgaaggc     1500

gcatggaagc aaatccagaa agtggagacg tgggccctca ggcatccgta atga           1554


<210>  145
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of DENV tetra EDIII-ectoM

<400>  145

Met Gly Ile Ile Phe Ile Leu Leu Met Leu Val Thr Pro Ser Met Ala 
1               5                   10                  15      


Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly Lys 
            20                  25                  30          


Phe Lys Ile Glu Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr Val 
        35                  40                  45              


Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro Ile 
    50                  55                  60                  


Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile Ser 
65                  70                  75                  80  


Ser Thr Pro Leu Ala Glu Asn Thr Asn Ser Val Thr Asn Ile Glu Leu 
                85                  90                  95      


Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asn Ser 
            100                 105                 110         


Ala Leu Thr Leu His Trp Phe Lys Lys Gly Ser Ser Ile Gly Arg Arg 
        115                 120                 125             


Asp Lys Arg Asp Lys Leu Lys Leu Lys Gly Met Ser Tyr Ala Met Cys 
    130                 135                 140                 


Thr Asn Thr Phe Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly 
145                 150                 155                 160 


Thr Ile Leu Ile Lys Val Glu Tyr Lys Gly Glu Asp Val Pro Cys Lys 
                165                 170                 175     


Ile Pro Phe Ser Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg 
            180                 185                 190         


Leu Ile Thr Ala Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn 
        195                 200                 205             


Ile Glu Ala Glu Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile 
    210                 215                 220                 


Gly Asp Asn Ala Leu Lys Ile Asn Trp Tyr Lys Lys Gly Ser Ser Ile 
225                 230                 235                 240 


Gly Arg Arg Asp Lys Arg Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr 
                245                 250                 255     


Ser Met Cys Thr Gly Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr 
            260                 265                 270         


Gln His Gly Thr Ile Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser 
        275                 280                 285             


Pro Cys Lys Ile Pro Phe Glu Ile Thr Asp Leu Glu Lys Arg His Val 
    290                 295                 300                 


Leu Gly Arg Leu Ile Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser 
305                 310                 315                 320 


Pro Val Asn Ile Glu Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile 
                325                 330                 335     


Val Gly Val Glu Pro Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly 
            340                 345                 350         


Ser Ser Ile Gly Arg Arg Asp Lys Arg Asp Lys Leu Thr Leu Lys Gly 
        355                 360                 365             


Met Ser Tyr Val Met Cys Thr Gly Ser Phe Lys Leu Glu Lys Glu Val 
    370                 375                 380                 


Ala Glu Thr Gln His Gly Thr Val Leu Val Gln Val Lys Tyr Glu Gly 
385                 390                 395                 400 


Thr Asp Ala Pro Cys Lys Ile Pro Phe Ser Thr Gln Asp Glu Lys Gly 
                405                 410                 415     


Val Thr Gln Asn Gly Arg Leu Ile Thr Ala Asn Pro Ile Val Thr Asp 
            420                 425                 430         


Lys Glu Lys Pro Val Asn Ile Glu Thr Glu Pro Pro Phe Gly Glu Ser 
        435                 440                 445             


Tyr Ile Ile Val Gly Ala Gly Glu Lys Ala Leu Lys Leu Ser Trp Phe 
    450                 455                 460                 


Lys Lys Gly Ser Ser Ile Gly Arg Arg Asp Lys Arg Ser Val Ala Leu 
465                 470                 475                 480 


Ala Pro His Val Gly Leu Gly Leu Glu Thr Arg Thr Glu Thr Trp Met 
                485                 490                 495     


Ser Ser Glu Gly Ala Trp Lys Gln Ile Gln Lys Val Glu Thr Trp Ala 
            500                 505                 510         


Leu Arg His Pro 
        515     


<210>  146
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the chimeric polyepitope of DENV2

<400>  146

Lys Ser Ile Glu Asp Asn Pro Glu Ile Glu Asp Asp Ile Phe Arg Lys 
1               5                   10                  15      


Lys Arg Leu Thr Ile Met Asp Leu His Pro Gly Ala Gly Lys Thr Lys 
            20                  25                  30          


Arg Tyr Leu Pro Ala Ile Val Arg Glu Ala Ile Lys Arg Gly Leu Arg 
        35                  40                  45              


Thr Leu Ile Leu Ala Pro Thr Arg Val Val Ala Ala Glu Met Glu Glu 
    50                  55                  60                  


Ala Leu Arg Gly Leu Pro Ile Arg Tyr Gln Thr Pro Ala Ile Arg Ala 
65                  70                  75                  80  


Glu His Thr Gly Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Phe 
                85                  90                  95      


Thr Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn Leu Ile 
            100                 105                 110         


Ile Met Asp Glu Ala His Phe Thr Asp Pro Ala Ser Ile Ala Ala Arg 
        115                 120                 125             


Gly Tyr Ile Ser Thr Arg Val Glu Met Gly Glu Ala Ala Gly Ile Phe 
    130                 135                 140                 


Met Thr Ala Thr Pro Pro Gly Ser Arg Asp Pro Phe Pro Gln Ser Asn 
145                 150                 155                 160 


Ala Pro Ile Met Asp Glu Glu Arg Glu Ile Pro Glu Arg Ser Trp Asn 
                165                 170                 175     


Ser Gly His Glu Trp Val Thr Asp Glu Asp Cys Ala His Trp Lys Glu 
            180                 185                 190         


Ala Lys Met Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile Pro 
        195                 200                 205             


Ser Met Phe Glu Pro Glu Arg Glu Lys Val Asp Ala Ile Asp Gly Glu 
    210                 215                 220                 


Tyr Arg Leu Arg Gly Glu Ala Arg Lys Thr Phe Val Asp Leu Met Arg 
225                 230                 235                 240 


Arg Gly Asp Leu Pro Val Trp Leu Ala Tyr Lys Val Ala Ala Glu Gly 
                245                 250                 255     


Ile Asn Tyr Ala Asp Arg Arg Trp Cys Phe Asp Gly Ile Lys Asn Asn 
            260                 265                 270         


Gln Ile Leu Glu Glu Asn Val Glu Val Glu Ile Trp Thr Lys Glu Gly 
        275                 280                 285             


Glu Arg Lys Lys Leu Lys Pro Arg Trp Leu Asp Ala Arg Ile Tyr Ser 
    290                 295                 300                 


Asp Pro Leu Ala Leu Lys Glu Phe Lys Glu Phe Ala Ala Gly Ile Thr 
305                 310                 315                 320 


Thr Gln Glu Ser Glu Ser Asn Ile Leu Asp Ile Asp Leu Arg Pro Ala 
                325                 330                 335     


Ser Ala Trp Thr Leu Tyr Ala Val Ala Thr Thr Phe Val Thr Pro Met 
            340                 345                 350         


Leu Arg His Ser Ile Glu Asn Ser Ser Val Asn Val Ser Leu Thr Ala 
        355                 360                 365             


Ile Ala Asn Gln Ala Thr Val Leu Met Gly Leu Gly Lys Gly Trp Pro 
    370                 375                 380                 


Leu Ser Lys Met Asp Ile Gly Val Pro Leu Leu Ala Ile Gly Cys Tyr 
385                 390                 395                 400 


Ser Gln Val Leu Asp Ile Ile Gly Lys Arg Ile Glu Lys Ile Lys Gln 
                405                 410                 415     


Glu His Glu Thr Ser Trp His Tyr Asp Gln Asp His Pro Tyr Lys Thr 
            420                 425                 430         


Trp Ala Tyr His Gly Ser Tyr Glu Thr Lys Gln Thr Gly Ser Ala Ser 
        435                 440                 445             


Ser Met Val Asn Gly Val Val Arg Leu Leu Thr Lys Pro Trp Asp Val 
    450                 455                 460                 


Val Pro Met Val Thr Gln Met Ala Met Thr Asp Thr Thr Pro Phe Gly 
465                 470                 475                 480 


Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg Thr Gln Glu Pro 
                485                 490                 495     


Lys Glu Gly Thr Lys Lys Leu Met Lys Ile Thr Ala Glu Trp Leu Trp 
            500                 505                 510         


Lys Glu Leu Gly Lys Lys Lys Thr Pro Arg Met Cys Thr Arg Glu Glu 
        515                 520                 525             


Phe Thr Arg Lys Val Arg Ser Asn Ala 
    530                 535         


<210>  147
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the chimeric polyepitope of DENV3

<400>  147

Ala Glu Pro Asp Gly Pro Thr Pro Glu Leu Glu Glu Glu Met Phe Lys 
1               5                   10                  15      


Lys Arg Asn Leu Thr Ile Met Asp Leu His Pro Gly Ser Gly Lys Thr 
            20                  25                  30          


Arg Lys Tyr Leu Pro Ala Ile Val Arg Glu Ala Ile Lys Arg Arg Leu 
        35                  40                  45              


Arg Thr Leu Ile Leu Ala Pro Thr Arg Val Val Ala Ala Glu Met Glu 
    50                  55                  60                  


Glu Ala Leu Lys Gly Leu Pro Ile Arg Tyr Gln Thr Thr Ala Thr Lys 
65                  70                  75                  80  


Ser Glu His Thr Gly Arg Glu Ile Val Asp Leu Met Cys His Ala Thr 
                85                  90                  95      


Phe Thr Met Arg Leu Leu Ser Pro Val Arg Val Pro Asn Tyr Asn Leu 
            100                 105                 110         


Ile Ile Met Asp Glu Ala His Phe Thr Asp Pro Ala Ser Ile Ala Ala 
        115                 120                 125             


Arg Gly Tyr Ile Ser Thr Arg Val Gly Met Gly Glu Ala Ala Ala Ile 
    130                 135                 140                 


Phe Met Thr Ala Thr Pro Pro Gly Thr Ala Asp Ala Phe Pro Gln Ser 
145                 150                 155                 160 


Asn Ala Pro Ile Gln Asp Glu Glu Arg Asp Ile Pro Glu Arg Ser Trp 
                165                 170                 175     


Asn Ser Gly Asn Glu Trp Ile Thr Asp Glu Asp His Ala His Trp Thr 
            180                 185                 190         


Glu Ala Lys Met Leu Leu Asp Asn Ile Asn Thr Pro Glu Gly Ile Ile 
        195                 200                 205             


Pro Ala Leu Phe Glu Pro Glu Arg Glu Lys Ser Ala Ala Ile Asp Gly 
    210                 215                 220                 


Glu Tyr Arg Leu Lys Gly Glu Ser Arg Lys Thr Phe Val Glu Leu Met 
225                 230                 235                 240 


Arg Arg Gly Asp Leu Pro Val Trp Leu Ala His Lys Val Ala Ser Glu 
                245                 250                 255     


Gly Ile Lys Tyr Thr Asp Arg Lys Trp Cys Phe Asp Gly Gln Arg Asn 
            260                 265                 270         


Asn Gln Ile Leu Glu Glu Asn Met Asp Val Glu Ile Trp Thr Lys Glu 
        275                 280                 285             


Gly Glu Lys Lys Lys Leu Arg Pro Arg Trp Leu Asp Ala Arg Thr Tyr 
    290                 295                 300                 


Ser Asp Pro Leu Ala Leu Lys Glu Phe Lys Asp Phe Ala Ala Gly Glu 
305                 310                 315                 320 


Pro Gly Val Val Ser Pro Thr Ser Tyr Leu Asp Val Asp Leu His Pro 
                325                 330                 335     


Ala Ser Ala Trp Thr Leu Tyr Ala Val Ala Thr Thr Val Ile Thr Pro 
            340                 345                 350         


Met Leu Arg His Thr Ile Glu Asn Ser Thr Ala Asn Val Ser Leu Ala 
        355                 360                 365             


Ala Ile Ala Asn Gln Ala Val Val Leu Met Gly Leu Asp Lys Gly Trp 
    370                 375                 380                 


Pro Ile Ser Lys Met Asp Leu Gly Val Pro Leu Leu Ala Leu Gly Cys 
385                 390                 395                 400 


Tyr Ser Gln Val Met Asp Val Ile Gly Glu Arg Ile Lys Arg Ile Lys 
                405                 410                 415     


Glu Glu His Asn Ser Thr Trp His Tyr Asp Asp Glu Asn Pro Tyr Lys 
            420                 425                 430         


Thr Trp Ala Tyr His Gly Ser Tyr Glu Val Lys Ala Thr Gly Ser Ala 
        435                 440                 445             


Ser Ser Met Ile Asn Gly Val Val Lys Leu Leu Thr Lys Pro Trp Asp 
    450                 455                 460                 


Val Val Pro Met Val Thr Gln Met Ala Met Thr Asp Thr Thr Pro Phe 
465                 470                 475                 480 


Gly Gln Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg Thr Pro Arg 
                485                 490                 495     


Ser Met Pro Gly Thr Arg Arg Val Met Gly Ile Thr Ala Glu Trp Leu 
            500                 505                 510         


Trp Arg Thr Leu Gly Arg Asn Lys Lys Pro Arg Leu Cys Thr Arg Glu 
        515                 520                 525             


Glu Phe Thr Lys Lys Val Arg Thr Asn Ala 
    530                 535             


<210>  148
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the chimeric polyepitope of DENV4

<400>  148

Arg Ile Gly Glu Pro Asp Tyr Glu Val Asp Glu Asp Ile Phe Arg Lys 
1               5                   10                  15      


Lys Arg Leu Thr Ile Met Asp Leu His Pro Gly Ala Gly Lys Thr Lys 
            20                  25                  30          


Arg Ile Leu Pro Ser Ile Val Arg Glu Ala Leu Lys Arg Arg Leu Arg 
        35                  40                  45              


Thr Leu Ile Leu Ala Pro Thr Arg Val Val Ala Ala Glu Met Glu Glu 
    50                  55                  60                  


Ala Leu Arg Gly Leu Pro Ile Arg Tyr Gln Thr Pro Ala Val Lys Ser 
65                  70                  75                  80  


Glu His Thr Gly Arg Glu Ile Val Asp Leu Met Cys His Ala Thr Phe 
                85                  90                  95      


Thr Thr Arg Leu Leu Ser Ser Thr Arg Val Pro Asn Tyr Asn Leu Ile 
            100                 105                 110         


Val Met Asp Glu Ala His Phe Thr Asp Pro Ser Ser Val Ala Ala Arg 
        115                 120                 125             


Gly Tyr Ile Ser Thr Arg Val Glu Met Gly Glu Ala Ala Ala Ile Phe 
    130                 135                 140                 


Met Thr Ala Thr Pro Pro Gly Ala Thr Asp Pro Phe Pro Gln Ser Asn 
145                 150                 155                 160 


Ser Pro Ile Glu Asp Ile Glu Arg Glu Ile Pro Glu Arg Ser Trp Asn 
                165                 170                 175     


Thr Gly Phe Asp Trp Ile Thr Asp Glu Asp His Ala His Trp Thr Glu 
            180                 185                 190         


Ala Lys Met Leu Leu Asp Asn Ile Tyr Thr Pro Glu Gly Ile Ile Pro 
        195                 200                 205             


Thr Leu Phe Gly Pro Glu Arg Glu Lys Thr Gln Ala Ile Asp Gly Glu 
    210                 215                 220                 


Phe Arg Leu Arg Gly Glu Gln Arg Lys Thr Phe Val Glu Leu Met Arg 
225                 230                 235                 240 


Arg Gly Asp Leu Pro Val Trp Leu Ser Tyr Lys Val Ala Ser Ala Gly 
                245                 250                 255     


Ile Ser Tyr Lys Asp Arg Glu Trp Cys Phe Thr Gly Glu Arg Asn Asn 
            260                 265                 270         


Gln Ile Leu Glu Glu Asn Met Glu Val Glu Ile Trp Thr Arg Glu Gly 
        275                 280                 285             


Glu Lys Lys Lys Leu Arg Pro Arg Trp Leu Asp Ala Arg Val Tyr Ala 
    290                 295                 300                 


Asp Pro Met Ala Leu Lys Asp Phe Lys Glu Phe Ala Ser Gly Val Lys 
305                 310                 315                 320 


Thr Glu Thr Thr Ile Leu Asp Val Asp Leu Arg Pro Ala Ser Ala Trp 
                325                 330                 335     


Thr Leu Tyr Ala Val Ala Thr Thr Ile Leu Thr Pro Met Leu Arg His 
            340                 345                 350         


Thr Ile Glu Asn Thr Ser Ala Asn Leu Ser Leu Ala Ala Ile Ala Asn 
        355                 360                 365             


Gln Ala Ala Val Leu Met Gly Leu Gly Lys Gly Trp Pro Leu His Arg 
    370                 375                 380                 


Met Asp Leu Gly Val Pro Leu Leu Ala Met Gly Cys Tyr Ser Gln Val 
385                 390                 395                 400 


Met Thr Ile Ile Gly Arg Arg Leu Gln Arg Leu Gln Glu Glu His Lys 
                405                 410                 415     


Glu Thr Trp His Tyr Asp Gln Glu Asn Pro Tyr Arg Thr Trp Ala Tyr 
            420                 425                 430         


His Gly Ser Tyr Glu Ala Pro Ser Thr Gly Ser Ala Ser Ser Met Val 
        435                 440                 445             


Asn Gly Val Val Lys Leu Leu Thr Lys Pro Trp Asp Val Ile Pro Met 
    450                 455                 460                 


Val Thr Gln Leu Ala Met Thr Asp Thr Thr Pro Phe Gly Gln Gln Arg 
465                 470                 475                 480 


Val Phe Lys Glu Lys Val Asp Thr Arg Thr Pro Gln Pro Lys Pro Gly 
                485                 490                 495     


Thr Arg Met Val Met Thr Thr Thr Ala Asn Trp Leu Trp Ala Leu Leu 
            500                 505                 510         


Gly Lys Lys Lys Asn Pro Arg Leu Cys Thr Arg Glu Glu Phe Ile Ser 
        515                 520                 525             


Lys Val Arg Ser Asn Ala 
    530                 


<210>  149
<211>  22243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Complete optimised nucleotide sequence of the polynucleotide 
       encoding pTM-MVDVax11


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  NotI

<220>
<221>  misc_feature
<222>  (9)..(28)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (29)..(82)
<223>  Hammerhead ribozyme

<220>
<221>  misc_feature
<222>  (83)..(189)
<223>  MV Leader and N promoter

<220>
<221>  misc_feature
<222>  (190)..(1767)
<223>  MV N ORF

<220>
<221>  misc_feature
<222>  (1768)..(1888)
<223>  MV N-P intergenic

<220>
<221>  misc_feature
<222>  (1889)..(3412)
<223>  MV P ORF

<220>
<221>  misc_feature
<222>  (3413)..(3531)
<223>  MV ATU2

<220>
<221>  misc_feature
<222>  (3532)..(6699)
<223>  DENV1 NS polyepitope/DENV tetra EDIII/ectoM

<220>
<221>  misc_feature
<222>  (6700)..(6813)
<223>  MV P-M intergenic

<220>
<221>  misc_feature
<222>  (6814)..(7803)
<223>  MV M ORF

<220>
<221>  misc_feature
<222>  (7804)..(8806)
<223>  MV M-F intergenic

<220>
<221>  misc_feature
<222>  (8807)..(10468)
<223>  MV F ORF

<220>
<221>  misc_feature
<222>  (10469)..(10628)
<223>  MV-F-H intergenic

<220>
<221>  misc_feature
<222>  (10629)..(12482)
<223>  MV H ORF

<220>
<221>  misc_feature
<222>  (12483)..(12591)
<223>  MV H-L intergenic

<220>
<221>  misc_feature
<222>  (12592)..(19143)
<223>  MV L ORF

<220>
<221>  misc_feature
<222>  (19144)..(19252)
<223>  MV Trailer

<220>
<221>  misc_feature
<222>  (19253)..(19336)
<223>  HDV ribozyme

<220>
<221>  misc_feature
<222>  (19337)..(19478)
<223>  T7 terminator

<220>
<221>  misc_feature
<222>  (19479)..(19486)
<223>  Not I

<220>
<221>  misc_feature
<222>  (19487)..(22243)
<223>  Not I

<400>  149
gcggccgcta atacgactca ctatagggcc aactttgttt ggtctgatga gtccgtgagg       60

acgaaacccg gagtcccggg tcaccaaaca aagttgggta aggatagttc aatcaatgat      120

catcttctag tgcacttagg attcaagatc ctattatcag ggacaagagc aggattaggg      180

atatccgaga tggccacact tttaaggagc ttagcattgt tcaaaagaaa caaggacaaa      240

ccacccatta catcaggatc cggtggagcc atcagaggaa tcaaacacat tattatagta      300

ccaatccctg gagattcctc aattaccact cgatccagac ttctggaccg gttggtgagg      360

ttaattggaa acccggatgt gagcgggccc aaactaacag gggcactaat aggtatatta      420

tccttatttg tggagtctcc aggtcaattg attcagagga tcaccgatga ccctgacgtt      480

agcataaggc tgttagaggt tgtccagagt gaccagtcac aatctggcct taccttcgca      540

tcaagaggta ccaacatgga ggatgaggcg gaccaatact tttcacatga tgatccaatt      600

agtagtgatc aatccaggtt cggatggttc gggaacaagg aaatctcaga tattgaagtg      660

caagaccctg agggattcaa catgattctg ggtaccatcc tagcccaaat ttgggtcttg      720

ctcgcaaagg cggttacggc cccagacacg gcagctgatt cggagctaag aaggtggata      780

aagtacaccc aacaaagaag ggtagttggt gaatttagat tggagagaaa atggttggat      840

gtggtgagga acaggattgc cgaggacctc tccttacgcc gattcatggt cgctctaatc      900

ctggatatca agagaacacc cggaaacaaa cccaggattg ctgaaatgat atgtgacatt      960

gatacatata tcgtagaggc aggattagcc agttttatcc tgactattaa gtttgggata     1020

gaaactatgt atcctgctct tggactgcat gaatttgctg gtgagttatc cacacttgag     1080

tccttgatga acctttacca gcaaatgggg gaaactgcac cctacatggt aatcctggag     1140

aactcaattc agaacaagtt cagtgcagga tcataccctc tgctctggag ctatgccatg     1200

ggagtaggag tggaacttga aaactccatg ggaggtttga actttggccg atcttacttt     1260

gatccagcat attttagatt agggcaagag atggtaagga ggtcagctgg aaaggtcagt     1320

tccacattgg catctgaact cggtatcact gccgaggatg caaggcttgt ttcagagatt     1380

gcaatgcata ctactgagga caagatcagt agagcggttg gacccagaca agcccaagta     1440

tcatttctac acggtgatca aagtgagaat gagctaccga gattgggggg caaggaagat     1500

aggagggtca aacagagtcg aggagaagcc agggagagct acagagaaac cgggcccagc     1560

agagcaagtg atgcgagagc tgcccatctt ccaaccggca cacccctaga cattgacact     1620

gcaacggagt ccagccaaga tccgcaggac agtcgaaggt cagctgacgc cctgcttagg     1680

ctgcaagcca tggcaggaat ctcggaagaa caaggctcag acacggacac ccctatagtg     1740

tacaatgaca gaaatcttct agactaggtg cgagaggccg agggccagaa caacatccgc     1800

ctaccatcca tcattgttat aaaaaactta ggaaccaggt ccacacagcc gccagcccat     1860

caaccatcca ctcccacgat tggagccaat ggcagaagag caggcacgcc atgtcaaaaa     1920

cggactggaa tgcatccggg ctctcaaggc cgagcccatc ggctcactgg ccatcgagga     1980

agctatggca gcatggtcag aaatatcaga caacccagga caggagcgag ccacctgcag     2040

ggaagagaag gcaggcagtt cgggtctcag caaaccatgc ctctcagcaa ttggatcaac     2100

tgaaggcggt gcacctcgca tccgcggtca gggacctgga gagagcgatg acgacgctga     2160

aactttggga atccccccaa gaaatctcca ggcatcaagc actgggttac agtgttatta     2220

cgtttatgat cacagcggtg aagcggttaa gggaatccaa gatgctgact ctatcatggt     2280

tcaatcaggc cttgatggtg atagcaccct ctcaggagga gacaatgaat ctgaaaacag     2340

cgatgtggat attggcgaac ctgataccga gggatatgct atcactgacc ggggatctgc     2400

tcccatctct atggggttca gggcttctga tgttgaaact gcagaaggag gggagatcca     2460

cgagctcctg agactccaat ccagaggcaa caactttccg aagcttggga aaactctcaa     2520

tgttcctccg cccccggacc ccggtagggc cagcacttcc gggacaccca ttaaaaaggg     2580

cacagacgcg agattagcct catttggaac ggagatcgcg tctttattga caggtggtgc     2640

aacccaatgt gctcgaaagt caccctcgga accatcaggg ccaggtgcac ctgcggggaa     2700

tgtccccgag tgtgtgagca atgccgcact gatacaggag tggacacccg aatctggtac     2760

cacaatctcc ccgagatccc agaataatga agaaggggga gactattatg atgatgagct     2820

gttctctgat gtccaagata ttaaaacagc cttggccaaa atacacgagg ataatcagaa     2880

gataatctcc aagctagaat cactgctgtt attgaaggga gaagttgagt caattaagaa     2940

gcagatcaac aggcaaaata tcagcatatc caccctggaa ggacacctct caagcatcat     3000

gatcgccatt cctggacttg ggaaggatcc caacgacccc actgcagatg tcgaaatcaa     3060

tcccgacttg aaacccatca taggcagaga ttcaggccga gcactggccg aagttctcaa     3120

gaaacccgtt gccagccgac aactccaagg aatgacaaat ggacggacca gttccagagg     3180

acagctgctg aaggaatttc agctaaagcc gatcgggaaa aagatgagct cagccgtcgg     3240

gtttgttcct gacaccggcc ctgcatcacg cagtgtaatc cgctccatta taaaatccag     3300

ccggctagag gaggatcgga agcgttacct gatgactctc cttgatgata tcaaaggagc     3360

caatgatctt gccaagttcc accagatgct gatgaagata ataatgaagt agctacagct     3420

caacttacct gccaacccca tgccagtcga cccaactagc ctaccctcca tcattgttat     3480

aaaaaactta ggaaccaggt ccacacagcc gccagcccat caacgcgtac gatggcatca     3540

caggagggac cactgcccga aattgaggac gaagtgttta gaaagcgaaa tctgactatt     3600

atggacctgc accccggatc tggcaagacc cggagatacc tgccagccat cgtgagggag     3660

gctattaagc ggaaactgag aacactgatc ctggccccaa ctcgcgtggt cgcttccgaa     3720

atggctgagg ccctgaaagg catgcccatc cggtatcaga ccacagcagt gaagtctgaa     3780

cataccggca aggagattgt ggacctgatg tgccacgcca ctttcaccat gcgactgctg     3840

agcccagtgc gggtccccaa ctacaatatg atcattatgg acgaggccca ctttactgat     3900

cccagctcca tcgccgctag aggatatatt tccaccaggg tgggaatggg cgaggcagca     3960

gctatcttca tgacagcaac tccccctggc agcgtggagg catttcctca gtccaacgcc     4020

gtcatccagg acgaggagcg ggacattcct gagcggagct ggaattctgg gtacgaatgg     4080

atcacagacg aggatcatgc acactggact gaagccaaga tgctgctgga caacattaat     4140

actcctgagg gaatcattcc agctctgttc gagcccgaaa gagagaagtc tgcagccatc     4200

gacggcgagt atagactgag gggagaggcc cggaagacct tcgtggaact gatgaggcgc     4260

ggcgatctgc ccgtgtggct gagttacaag gtcgcttcag agggattcca gtatagtgac     4320

cgacggtggt gctttgatgg cgaacgcaac aatcaggtgc tggaggagaa catggatgtc     4380

gagatttgga caaaggaagg cgagcggaag aaactgcgcc cacgatggct ggacgctcgg     4440

acttacagcg atcccctggc actgagagaa ttcaaagagt ttgctgcagg ggtggccgtc     4500

gagaatcacc atcacgccgc tatgctggac gtggatctgc atcctgccag tgcttggacc     4560

ctgtatgcag tggccactac catcattacc ccaatgatgc gccacacaat cgagaacaca     4620

actgccaata tctcactgac agctattgca aaccaggcag ccattctgat gggactggac     4680

aaaggctggc ccatcagcaa gatggatatt ggcgtgcctc tgctggccct ggggtgttac     4740

agtcaggtgc tggacatcat tggccagagg atcgagaaca ttaagcatga gcacaaatca     4800

acctggcatt acgacgaaga taatccctat aagacatggg cctaccacgg aagctatgag     4860

gtgaaacctt caggcagcgc cagcagcatg gtcaacgggg tggtcaagct gctgaccaaa     4920

ccttgggacg tgatcccaat ggtcactcag attgccatga ccgataccac cccattcggc     4980

cagcagcggg tgttcaagga gaaggtggac acccgcacac ctaaggctaa acgagggact     5040

gcacagatca tggaggtgac cgccaagtgg ctgtggggat tcctgtccag gaacaagaag     5100

ccaagaatct gtaccaggga agagttcaca agaaaggtcc ggtcaaacgc cggcatcata     5160

ttcattcttc ttatgctggt tacaccgtct atggcggaga aacttcgaat caaaggtatg     5220

agctatacga tgtgcagcgg caagttcaag atcgagaagg aaatggctga aacccagcac     5280

ggtacaactg tggtcaaagt caaatatgag ggggctggcg ctccctgtaa agtacccatt     5340

gagattaggg acgtcaataa agagaaggtg gtaggtcgca tcatctccag tacacctttg     5400

gccgagaaca cgaactccgt cacaaacata gagttggaac ccccgttcgg agactcatac     5460

attgtgatcg gggtgggcaa ctctgcactc acactgcatt ggttcaagaa gggaagcagt     5520

atcggccgca gggataagag agacaaactg aaattgaaag gtatgtccta tgccatgtgc     5580

acgaatactt tcgttctcaa gaaagaagta tctgagactc agcacggaac catcctgatc     5640

aaagtcgagt acaaaggaga agacgtgccc tgtaagatcc cattcagtac cgaggatgga     5700

cagggcaagg cccataacgg caggctgata accgccaacc ctgtggttac aaagaaggaa     5760

gagccagtca atatcgaagc tgagccaccg ttcggggaga gcaacatagt aattggcata     5820

ggggataatg ctttgaagat caactggtac aagaaaggaa gctccattgg ccgaagagat     5880

aagcgcgaca aactccagct gaaaggaatg agctactcca tgtgtactgg gaagttcaag     5940

attgtcaagg aaatcgccga aactcagcat ggcactattg tgatccgcgt gcagtatgaa     6000

ggcgatggta gcccctgcaa gataccattt gaaatcaccg atttggagaa acggcacgtc     6060

ctgggtcggc tcattaccgt gaacccaatc gtgaccgaga aggacagtcc agttaatatc     6120

gaggccgagc ctcctttcgg cgacagttac atcattgtag gggtggaacc agggcaactg     6180

aagctgaact ggttcaagaa aggcagcagt ataggacggc gggataaacg ggacaaactc     6240

acactgaaag gcatgtcata cgttatgtgc accggctcat tcaaactgga gaaggaagtt     6300

gcagagacac agcatgggac cgtgctcgtg caggtcaaat acgagggcac cgacgctcct     6360

tgcaagattc cgttcagtac acaggacgag aaaggcgtga ctcagaacgg cagattgatt     6420

acagcgaacc ctatcgtgac tgacaaggag aagccagtta acatcgagac tgagccgcct     6480

ttcggagaat catacattat cgtgggagcc ggcgagaagg cactgaaact cagctggttc     6540

aagaagggca gctcaatcgg tcggagagac aagcggtctg tcgccctcgc accgcacgtg     6600

ggcctgggtc tggaaacgag gaccgagacg tggatgagtt ccgaaggcgc atggaagcaa     6660

atccagaaag tggagacgtg ggccctcagg catccgtaag cgcgcagcgc ttagacgtct     6720

cgcgatcgat actagtacaa cctaaatcca ttataaaaaa cttaggagca aagtgattgc     6780

ctcccaaggt ccacaatgac agagacctac gacttcgaca agtcggcatg ggacatcaaa     6840

gggtcgatcg ctccgataca acccaccacc tacagtgatg gcaggctggt gccccaggtc     6900

agagtcatag atcctggtct aggcgacagg aaggatgaat gctttatgta catgtttctg     6960

ctgggggttg ttgaggacag cgattcccta gggcctccaa tcgggcgagc atttgggttc     7020

ctgcccttag gtgttggcag atccacagca aagcccgaaa aactcctcaa agaggccact     7080

gagcttgaca tagttgttag acgtacagca gggctcaatg aaaaactggt gttctacaac     7140

aacaccccac taactctcct cacaccttgg agaaaggtcc taacaacagg gagtgtcttc     7200

aacgcaaacc aagtgtgcaa tgcggttaat ctgataccgc tcgatacccc gcagaggttc     7260

cgtgttgttt atatgagcat cacccgtctt tcggataacg ggtattacac cgttcctaga     7320

agaatgctgg aattcagatc ggtcaatgca gtggccttca acctgctggt gacccttagg     7380

attgacaagg cgataggccc tgggaagatc atcgacaata cagagcaact tcctgaggca     7440

acatttatgg tccacatcgg gaacttcagg agaaagaaga gtgaagtcta ctctgccgat     7500

tattgcaaaa tgaaaatcga aaagatgggc ctggtttttg cacttggtgg gatagggggc     7560

accagtcttc acattagaag cacaggcaaa atgagcaaga ctctccatgc acaactcggg     7620

ttcaagaaga ccttatgtta cccgctgatg gatatcaatg aagaccttaa tcgattactc     7680

tggaggagca gatgcaagat agtaagaatc caggcagttt tgcagccatc agttcctcaa     7740

gaattccgca tttacgacga cgtgatcata aatgatgacc aaggactatt caaagttctg     7800

tagaccgtag tgcccagcaa tgcccgaaaa cgacccccct cacaatgaca gccagaaggc     7860

ccggacaaaa aagccccctc cgaaagactc cacggaccaa gcgagaggcc agccagcagc     7920

cgacggcaag cgcgaacacc aggcggcccc agcacagaac agccctgaca caaggccacc     7980

accagccacc ccaatctgca tcctcctcgt gggacccccg aggaccaacc cccaaggctg     8040

cccccgatcc aaaccaccaa ccgcatcccc accacccccg ggaaagaaac ccccagcaat     8100

tggaaggccc ctccccctct tcctcaacac aagaactcca caaccgaacc gcacaagcga     8160

ccgaggtgac ccaaccgcag gcatccgact ccctagacag atcctctctc cccggcaaac     8220

taaacaaaac ttagggccaa ggaacataca cacccaacag aacccagacc ccggcccacg     8280

gcgccgcgcc cccaaccccc gacaaccaga gggagccccc aaccaatccc gccggctccc     8340

ccggtgccca caggcaggga caccaacccc cgaacagacc cagcacccaa ccatcgacaa     8400

tccaagacgg gggggccccc ccaaaaaaag gcccccaggg gccgacagcc agcaccgcga     8460

ggaagcccac ccaccccaca cacgaccacg gcaaccaaac cagaacccag accaccctgg     8520

gccaccagct cccagactcg gccatcaccc cgcagaaagg aaaggccaca acccgcgcac     8580

cccagccccg atccggcggg gagccaccca acccgaacca gcacccaaga gcgatccccg     8640

aaggaccccc gaaccgcaaa ggacatcagt atcccacagc ctctccaagt cccccggtct     8700

cctcctcttc tcgaagggac caaaagatca atccaccaca cccgacgaca ctcaactccc     8760

cacccctaaa ggagacaccg ggaatcccag aatcaagact catccaatgt ccatcatggg     8820

tctcaaggtg aacgtctctg ccatattcat ggcagtactg ttaactctcc aaacacccac     8880

cggtcaaatc cattggggca atctctctaa gataggggtg gtaggaatag gaagtgcaag     8940

ctacaaagtt atgactcgtt ccagccatca atcattagtc ataaaattaa tgcccaatat     9000

aactctcctc aataactgca cgagggtaga gattgcagaa tacaggagac tactgagaac     9060

agttttggaa ccaattagag atgcacttaa tgcaatgacc cagaatataa gaccggttca     9120

gagtgtagct tcaagtagga gacacaagag atttgcggga gtagtcctgg caggtgcggc     9180

cctaggcgtt gccacagctg ctcagataac agccggcatt gcacttcacc agtccatgct     9240

gaactctcaa gccatcgaca atctgagagc gagcctggaa actactaatc aggcaattga     9300

gacaatcaga caagcagggc aggagatgat attggctgtt cagggtgtcc aagactacat     9360

caataatgag ctgataccgt ctatgaacca actatcttgt gatttaatcg gccagaagct     9420

cgggctcaaa ttgctcagat actatacaga aatcctgtca ttatttggcc ccagtttacg     9480

ggaccccata tctgcggaga tatctatcca ggctttgagc tatgcgcttg gaggagacat     9540

caataaggtg ttagaaaagc tcggatacag tggaggtgat ttactgggca tcttagagag     9600

cggaggaata aaggcccgga taactcacgt cgacacagag tcctacttca ttgtcctcag     9660

tatagcctat ccgacgctgt ccgagattaa gggggtgatt gtccaccggc tagagggggt     9720

ctcgtacaac ataggctctc aagagtggta taccactgtg cccaagtatg ttgcaaccca     9780

agggtacctt atctcgaatt ttgatgagtc atcgtgtact ttcatgccag aggggactgt     9840

gtgcagccaa aatgccttgt acccgatgag tcctctgctc caagaatgcc tccgggggta     9900

caccaagtcc tgtgctcgta cactcgtatc cgggtctttt gggaaccggt tcattttatc     9960

acaagggaac ctaatagcca attgtgcatc aatcctttgc aagtgttaca caacaggaac    10020

gatcattaat caagaccctg acaagatcct aacatacatt gctgccgatc actgcccggt    10080

agtcgaggtg aacggcgtga ccatccaagt cgggagcagg aggtatccag acgctgtgta    10140

cttgcacaga attgacctcg gtcctcccat atcattggag aggttggacg tagggacaaa    10200

tctggggaat gcaattgcta agttggagga tgccaaggaa ttgttggagt catcggacca    10260

gatattgagg agtatgaaag gtttatcgag cactagcata gtctacatcc tgattgcagt    10320

gtgtcttgga gggttgatag ggatccccgc tttaatatgt tgctgcaggg ggcgttgtaa    10380

caaaaaggga gaacaagttg gtatgtcaag accaggccta aagcctgatc ttacgggaac    10440

atcaaaatcc tatgtaaggt cgctctgatc ctctacaact cttgaaacac aaatgtccca    10500

caagtctcct cttcgtcatc aagcaaccac cgcacccagc atcaagccca cctgaaatta    10560

tctccggctt ccctctggcc gaacaatatc ggtagttaat caaaacttag ggtgcaagat    10620

catccacaat gtcaccacaa cgagaccgga taaatgcctt ctacaaagat aacccccatc    10680

ccaagggaag taggatagtc attaacagag aacatcttat gattgataga ccttatgttt    10740

tgctggctgt tctgtttgtc atgtttctga gcttgatcgg gttgctagcc attgcaggca    10800

ttagacttca tcgggcagcc atctacaccg cagagatcca taaaagcctc agcaccaatc    10860

tagatgtaac taactcaatc gagcatcagg tcaaggacgt gctgacacca ctcttcaaaa    10920

tcatcggtga tgaagtgggc ctgaggacac ctcagagatt cactgaccta gtgaaattaa    10980

tctctgacaa gattaaattc cttaatccgg atagggagta cgacttcaga gatctcactt    11040

ggtgtatcaa cccgccagag agaatcaaat tggattatga tcaatactgt gcagatgtgg    11100

ctgctgaaga gctcatgaat gcattggtga actcaactct actggagacc agaacaacca    11160

atcagttcct agctgtctca aagggaaact gctcagggcc cactacaatc agaggtcaat    11220

tctcaaacat gtcgctgtcc ctgttagact tgtatttagg tcgaggttac aatgtgtcat    11280

ctatagtcac tatgacatcc cagggaatgt atgggggaac ttacctagtg gaaaagccta    11340

atctgagcag caaaaggtca gagttgtcac aactgagcat gtaccgagtg tttgaagtag    11400

gtgttatcag aaatccgggt ttgggggctc cggtgttcca tatgacaaac tatcttgagc    11460

aaccagtcag taatgatctc agcaactgta tggtggcttt gggggagctc aaactcgcag    11520

ccctttgtca cggggaagat tctatcacaa ttccctatca gggatcaggg aaaggtgtca    11580

gcttccagct cgtcaagcta ggtgtctgga aatccccaac cgacatgcaa tcctgggtcc    11640

ccttatcaac ggatgatcca gtgatagaca ggctttacct ctcatctcac agaggtgtta    11700

tcgctgacaa tcaagcaaaa tgggctgtcc cgacaacacg aacagatgac aagttgcgaa    11760

tggagacatg cttccaacag gcgtgtaagg gtaaaatcca agcactctgc gagaatcccg    11820

agtgggcacc attgaaggat aacaggattc cttcatacgg ggtcttgtct gttgatctga    11880

gtctgacagt tgagcttaaa atcaaaattg cttcgggatt cgggccattg atcacacacg    11940

gttcagggat ggacctatac aaatccaacc acaacaatgt gtattggctg actatcccgc    12000

caatgaagaa cctagcctta ggtgtaatca acacattgga gtggataccg agattcaagg    12060

ttagtcccta cctcttcact gtcccaatta aggaagcagg cgaagactgc catgccccaa    12120

catacctacc tgcggaggtg gatggtgatg tcaaactcag ttccaatctg gtgattctac    12180

ctggtcaaga tctccaatat gttttggcaa cctacgatac ttccagggtt gaacatgctg    12240

tggtttatta cgtttacagc ccaagccgct cattttctta cttttatcct tttaggttgc    12300

ctataaaggg ggtccccatc gaattacaag tggaatgctt cacatgggac caaaaactct    12360

ggtgccgtca cttctgtgtg cttgcggact cagaatctgg tggacatatc actcactctg    12420

ggatggtggg catgggagtc agctgcacag tcacccggga agatggaacc aatcgcagat    12480

agggctgcta gtgaaccaat cacatgatgt cacccagaca tcaggcatac ccactagtgt    12540

gaaatagaca tcagaattaa gaaaaacgta gggtccaagt ggttccccgt tatggactcg    12600

ctatctgtca accagatctt ataccctgaa gttcacctag atagcccgat agttaccaat    12660

aagatagtag ccatcctgga gtatgctcga gtccctcacg cttacagcct ggaggaccct    12720

acactgtgtc agaacatcaa gcaccgccta aaaaacggat tttccaacca aatgattata    12780

aacaatgtgg aagttgggaa tgtcatcaag tccaagctta ggagttatcc ggcccactct    12840

catattccat atccaaattg taatcaggat ttatttaaca tagaagacaa agagtcaacg    12900

aggaagatcc gtgaactcct caaaaagggg aattcgctgt actccaaagt cagtgataag    12960

gttttccaat gcttaaggga cactaactca cggcttggcc taggctccga attgagggag    13020

gacatcaagg agaaagttat taacttggga gtttacatgc acagctccca gtggtttgag    13080

ccctttctgt tttggtttac agtcaagact gagatgaggt cagtgattaa atcacaaacc    13140

catacttgcc ataggaggag acacacacct gtattcttca ctggtagttc agttgagttg    13200

ctaatctctc gtgaccttgt tgctataatc agtaaagagt ctcaacatgt atattacctg    13260

acatttgaac tggttttgat gtattgtgat gtcatagagg ggaggttaat gacagagacc    13320

gctatgacta ttgatgctag gtatacagag cttctaggaa gagtcagata catgtggaaa    13380

ctgatagatg gtttcttccc tgcactcggg aatccaactt atcaaattgt agccatgctg    13440

gagcctcttt cacttgctta cctgcagctg agggatataa cagtagaact cagaggtgct    13500

ttccttaacc actgctttac tgaaatacat gatgttcttg accaaaacgg gttttctgat    13560

gaaggtactt atcatgagtt aactgaagct ctagattaca ttttcataac tgatgacata    13620

catctgacag gggagatttt ctcatttttc agaagtttcg gccaccccag acttgaagca    13680

gtaacggctg ctgaaaatgt taggaaatac atgaatcagc ctaaagtcat tgtgtatgag    13740

actctgatga aaggtcatgc catattttgt ggaatcataa tcaacggcta tcgtgacagg    13800

cacggaggca gttggccacc gctgaccctc cccctgcatg ctgcagacac aatccggaat    13860

gctcaagctt caggtgaagg gttaacacat gagcagtgcg ttgataactg gaaatctttt    13920

gctggagtga aatttggctg ctttatgcct cttagcctgg atagtgatct gacaatgtac    13980

ctaaaggaca aggcacttgc tgctctccaa agggaatggg attcagttta cccgaaagag    14040

ttcctgcgtt acgaccctcc caagggaacc gggtcacgga ggcttgtaga tgttttcctt    14100

aatgattcga gctttgaccc atatgatgtg ataatgtatg ttgtaagtgg agcttacctc    14160

catgaccctg agttcaacct gtcttacagc ctgaaagaaa aggagatcaa ggaaacaggt    14220

agactttttg ctaaaatgac ttacaaaatg agggcatgcc aagtgattgc tgaaaatcta    14280

atctcaaacg ggattggcaa atattttaag gacaatggga tggccaagga tgagcacgat    14340

ttgactaagg cactccacac tctagctgtc tcaggagtcc ccaaagatct caaagaaagt    14400

cacagggggg ggccagtctt aaaaacctac tcccgaagcc cagtccacac aagtaccagg    14460

aacgtgagag cagcaaaagg gtttataggg ttccctcaag taattcggca ggaccaagac    14520

actgatcatc cggagaatat ggaagcttac gagacagtca gtgcatttat cacgactgat    14580

ctcaagaagt actgccttaa ttggagatat gagaccatca gcttgtttgc acagaggcta    14640

aatgagattt acggattgcc ctcatttttc cagtggctgc ataagaggct tgagacctct    14700

gtcctgtatg taagtgaccc tcattgcccc cccgaccttg acgcccatat cccgttatat    14760

aaagtcccca atgatcaaat cttcattaag taccctatgg gaggtataga agggtattgt    14820

cagaagctgt ggaccatcag caccattccc tatctatacc tggctgctta tgagagcgga    14880

gtaaggattg cttcgttagt gcaaggggac aatcagacca tagccgtaac aaaaagggta    14940

cccagcacat ggccctacaa ccttaagaaa cgggaagctg ctagagtaac tagagattac    15000

tttgtaattc ttaggcaaag gctacatgat attggccatc acctcaaggc aaatgagaca    15060

attgtttcat cacatttttt tgtctattca aaaggaatat attatgatgg gctacttgtg    15120

tcccaatcac tcaagagcat cgcaagatgt gtattctggt cagagactat agttgatgaa    15180

acaagggcag catgcagtaa tattgctaca acaatggcta aaagcatcga gagaggttat    15240

gaccgttacc ttgcatattc cctgaacgtc ctaaaagtga tacagcaaat tctgatctct    15300

cttggcttca caatcaattc aaccatgacc cgggatgtag tcatacccct cctcacaaac    15360

aacgacctct taataaggat ggcactgttg cccgctccta ttggggggat gaattatctg    15420

aatatgagca ggctgtttgt cagaaacatc ggtgatccag taacatcatc aattgctgat    15480

ctcaagagaa tgattctcgc ctcactaatg cctgaagaga ccctccatca agtaatgaca    15540

caacaaccgg gggactcttc attcctagac tgggctagcg acccttactc agcaaatctt    15600

gtatgtgtcc agagcatcac tagactcctc aagaacataa ctgcaaggtt tgtcctgatc    15660

catagtccaa acccaatgtt aaaaggatta ttccatgatg acagtaaaga agaggacgag    15720

ggactggcgg cattcctcat ggacaggcat attatagtac ctagggcagc tcatgaaatc    15780

ctggatcata gtgtcacagg ggcaagagag tctattgcag gcatgctgga taccacaaaa    15840

ggcttgattc gagccagcat gaggaagggg gggttaacct ctcgagtgat aaccagattg    15900

tccaattatg actatgaaca attcagagca gggatggtgc tattgacagg aagaaagaga    15960

aatgtcctca ttgacaaaga gtcatgttca gtgcagctgg cgagagctct aagaagccat    16020

atgtgggcga ggctagctcg aggacggcct atttacggcc ttgaggtccc tgatgtacta    16080

gaatctatgc gaggccacct tattcggcgt catgagacat gtgtcatctg cgagtgtgga    16140

tcagtcaact acggatggtt ttttgtcccc tcgggttgcc aactggatga tattgacaag    16200

gaaacatcat ccttgagagt cccatatatt ggttctacca ctgatgagag aacagacatg    16260

aagcttgcct tcgtaagagc cccaagtcga tccttgcgat ctgctgttag aatagcaaca    16320

gtgtactcat gggcttacgg tgatgatgat agctcttgga acgaagcctg gttgttggct    16380

aggcaaaggg ccaatgtgag cctggaggag ctaagggtga tcactcccat ctcaacttcg    16440

actaatttag cgcataggtt gagggatcgt agcactcaag tgaaatactc aggtacatcc    16500

cttgtccgag tggcgaggta taccacaatc tccaacgaca atctctcatt tgtcatatca    16560

gataagaagg ttgatactaa ctttatatac caacaaggaa tgcttctagg gttgggtgtt    16620

ttagaaacat tgtttcgact cgagaaagat accggatcat ctaacacggt attacatctt    16680

cacgtcgaaa cagattgttg cgtgatcccg atgatagatc atcccaggat acccagctcc    16740

cgcaagctag agctgagggc agagctatgt accaacccat tgatatatga taatgcacct    16800

ttaattgaca gagatgcaac aaggctatac acccagagcc ataggaggca ccttgtggaa    16860

tttgttacat ggtccacacc ccaactatat cacattttag ctaagtccac agcactatct    16920

atgattgacc tggtaacaaa atttgagaag gaccatatga atgaaatttc agctctcata    16980

ggggatgacg atatcaatag tttcataact gagtttctgc tcatagagcc aagattattc    17040

actatctact tgggccagtg tgcggccatc aattgggcat ttgatgtaca ttatcataga    17100

ccatcaggga aatatcagat gggtgagctg ttgtcatcgt tcctttctag aatgagcaaa    17160

ggagtgttta aggtgcttgt caatgctcta agccacccaa agatctacaa gaaattctgg    17220

cattgtggta ttatagagcc tatccatggt ccttcacttg atgctcaaaa cttgcacaca    17280

actgtgtgca acatggttta cacatgctat atgacctacc tcgacctgtt gttgaatgaa    17340

gagttagaag agttcacatt tctcttgtgt gaaagcgacg aggatgtagt accggacaga    17400

ttcgacaaca tccaggcaaa acacttatgt gttctggcag atttgtactg tcaaccaggg    17460

acctgcccac caattcgagg tctaagaccg gtagagaaat gtgcagttct aaccgaccat    17520

atcaaggcag aggctatgtt atctccagca ggatcttcgt ggaacataaa tccaattatt    17580

gtagaccatt actcatgctc tctgacttat ctccggcgag gatcgatcaa acagataaga    17640

ttgagagttg atccaggatt cattttcgac gccctcgctg aggtaaatgt cagtcagcca    17700

aagatcggca gcaacaacat ctcaaatatg agcatcaagg ctttcagacc cccacacgat    17760

gatgttgcaa aattgctcaa agatatcaac acaagcaagc acaatcttcc catttcaggg    17820

ggcaatctcg ccaattatga aatccatgct ttccgcagaa tcgggttgaa ctcatctgct    17880

tgctacaaag ctgttgagat atcaacatta attaggagat gccttgagcc aggggaggac    17940

ggcttgttct tgggtgaggg atcgggttct atgttgatca cttataaaga gatacttaaa    18000

ctaaacaagt gcttctataa tagtggggtt tccgccaatt ctagatctgg tcaaagggaa    18060

ttagcaccct atccctccga agttggcctt gtcgaacaca gaatgggagt aggtaatatt    18120

gtcaaagtgc tctttaacgg gaggcccgaa gtcacgtggg taggcagtgt agattgcttc    18180

aatttcatag ttagtaatat ccctacctct agtgtggggt ttatccattc agatatagag    18240

accttgcctg acaaagatac tatagagaag ctagaggaat tggcagccat cttatcgatg    18300

gctctgctcc tgggcaaaat aggatcaata ctggtgatta agcttatgcc tttcagcggg    18360

gattttgttc agggatttat aagttatgta gggtctcatt atagagaagt gaaccttgta    18420

taccctagat acagcaactt catctctact gaatcttatt tggttatgac agatctcaag    18480

gctaaccggc taatgaatcc tgaaaagatt aagcagcaga taattgaatc atctgtgagg    18540

acttcacctg gacttatagg tcacatccta tccattaagc aactaagctg catacaagca    18600

attgtgggag acgcagttag tagaggtgat atcaatccta ctctgaaaaa acttacacct    18660

atagagcagg tgctgatcaa ttgcgggttg gcaattaacg gacctaagct gtgcaaagaa    18720

ttgatccacc atgatgttgc ctcagggcaa gatggattgc ttaattctat actcatcctc    18780

tacagggagt tggcaagatt caaagacaac caaagaagtc aacaagggat gttccacgct    18840

taccccgtat tggtaagtag caggcaacga gaacttatat ctaggatcac ccgcaaattc    18900

tgggggcaca ttcttcttta ctccgggaac aaaaagttga taaataagtt tatccagaat    18960

ctcaagtccg gctatctgat actagactta caccagaata tcttcgttaa gaatctatcc    19020

aagtcagaga aacagattat tatgacgggg ggtttgaaac gtgagtgggt ttttaaggta    19080

acagtcaagg agaccaaaga atggtataag ttagtcggat acagtgccct gattaaggac    19140

taattggttg aactccggaa ccctaatcct gccctaggtg gttaggcatt atttgcaata    19200

tattaaagaa aactttgaaa atacgaagtt tctattccca gctttgtctg gtggccggca    19260

tggtcccagc ctcctcgctg gcgccggctg ggcaacattc cgaggggacc gtcccctcgg    19320

taatggcgaa tgggacgcgg ccgatccggc tgctaacaaa gcccgaaagg aagctgagtt    19380

ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta aacgggtctt    19440

gaggggtttt ttgctgaaag gaggaactat atccggatgc ggccgcgggc cctatggtac    19500

ccagcttttg ttccctttag tgagggttaa ttccgagctt ggcgtaatca tggtcatagc    19560

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatagga gccggaagca    19620

taaagtgtaa agcctggggt gcctaatgag tgaggtaact cacattaatt gcgttgcgct    19680

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac    19740

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc    19800

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt    19860

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg    19920

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctcggc ccccctgacg    19980

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat    20040

accaggcgtt cccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta    20100

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct    20160

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc    20220

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa    20280

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg    20340

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag    20400

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt    20460

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta    20520

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc    20580

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca    20640

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa    20700

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat    20760

ttcgttcatc catagttgcc tgactgcccg tcgtgtagat aactacgata cgggagggct    20820

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt    20880

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat    20940

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta    21000

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg    21060

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt    21120

tgtgaaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg    21180

cagtgttatc actcatgctt atggcagcac tgcataattc tcttactgtc atgccatccg    21240

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc    21300

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa    21360

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac    21420

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt    21480

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg    21540

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa    21600

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata    21660

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgaaatt gtaaacgtta    21720

atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg    21780

ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg    21840

ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa    21900

aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg    21960

ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt    22020

gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg    22080

ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta    22140

atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt tgggaagggc    22200

gatcggtgcg ggcctcttcg ctattacgcc agccaccgcg gtg                      22243


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide HBSP A2-2

<400>  150

Thr Leu Cys Ile Pro His Val Ala Val 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide Sv B7-3

<400>  151

Ser Pro Phe Leu Pro Leu Leu Pro Ile 
1               5                   


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic furin sites

<400>  152

Arg Arg Asp Lys Arg 
1               5   


