               SEQUENCE LISTING

<110> GENETHON
      ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE

<120> EFFICIENT SYSTEMIC TREATMENT OF DYSTROPHIC PATHOLOGIES

<130> G143-B-43539 PCT

<150> EP14174848.3
<151> 2014-06-27

<160> 8

<170> BiSSAP 1.3

<210> 1
<211> 4640
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV_ITR_Spc512-human MD1

<400> 1
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctag      180

acatggctcg acagatcgag ctccaccgcg gtggcggccg tccgccctcg gcaccatcct      240

cacgacaccc aaatatggcg acgggtgagg aatggtgggg agttattttt agagcggtga      300

ggaaggtggg caggcagcag gtgttggcgc tctaaaaata actcccggga gttattttta      360

gagcggagga atggtggaca cccaaatatg gcgacggttc ctcacccgtc gccatatttg      420

ggtgtccgcc ctcggccggg gccgcattcc tgggggccgg gcggtgctcc cgcccgcctc      480

gataaaaggc tccggggccg gcggcggccc acgagctacc cggaggagcg ggaggcgcca      540

agctctagaa ctagtggatc ccccgggctg caggaattcg ccaccatgct gtggtgggag      600

gaagtggagg actgctacga gagagaggac gtgcagaaga aaaccttcac caagtgggtg      660

aacgcccagt tcagcaagtt cggcaagcag cacatcgaga acctgttcag cgacctgcag      720

gatggcagga gactgctgga tctgctggag ggactgaccg gccagaagct gcccaaggag      780

aagggcagca ccagagtgca cgccctgaac aacgtgaaca aggccctgag agtgctgcag      840

aacaacaacg tggacctggt gaatatcggc agcaccgaca tcgtggacgg caaccacaag      900

ctgaccctgg gcctgatctg gaacatcatc ctgcactggc aggtgaagaa cgtgatgaag      960

aacatcatgg ccggcctgca gcagaccaac agcgagaaga tcctgctgag ctgggtgagg     1020

cagagcacca gaaactaccc ccaggtgaac gtgatcaact tcaccacctc ctggagcgac     1080

ggcctggccc tgaacgccct gatccacagc cacagacccg acctgttcga ctggaacagc     1140

gtggtgtgtc agcagagcgc cacccagaga ctggagcacg ccttcaacat cgccagatac     1200

cagctgggca tcgagaagct gctggacccc gaggacgtgg acaccaccta ccccgacaag     1260

aaaagcatcc tgatgtatat tacctctctg tttcaggtgc tgccccagca ggtgtccatc     1320

gaggccatcc aggaagtgga aatgctgccc aggcccccca aagtgaccaa ggaggagcac     1380

ttccagctgc accaccagat gcactatagc cagcagatca ccgtgtccct ggcccagggc     1440

tatgagagaa ccagcagccc caagcccaga ttcaagagct acgcctacac ccaggccgcc     1500

tacgtgacca cctccgaccc caccagaagc cccttcccca gccagcacct ggaggccccc     1560

gaggacaaga gcttcggcag cagcctgatg gagagcgaag tgaacctgga cagataccag     1620

accgccctgg aggaagtgct gtcttggctg ctgtccgccg aggacaccct gcaggcccag     1680

ggcgagatca gcaacgacgt ggaagtggtg aaggaccagt tccacaccca cgagggctac     1740

atgatggatc tgaccgccca ccagggcaga gtgggcaata tcctgcagct gggcagcaag     1800

ctgatcggca ccggcaagct gagcgaggac gaggagaccg aagtgcagga gcagatgaac     1860

ctgctgaaca gcagatggga gtgcctgaga gtggccagca tggagaagca gagcaacctg     1920

caccgcgtgc tgatggacct gcagaaccag aagctgaagg agctgaacga ctggctgacc     1980

aagaccgagg agcggaccag aaagatggag gaggagcccc tgggccccga cctggaggac     2040

ctgaagagac aggtgcagca gcacaaagtg ctgcaggagg acctggaaca ggagcaggtg     2100

cgcgtgaaca gcctgaccca catggtggtc gtggtggacg agagcagcgg cgaccacgcc     2160

acagccgccc tggaagagca gctgaaagtg ctgggcgaca gatgggccaa catctgccgg     2220

tggaccgagg acagatgggt gctgctgcag gacatcctgc tgaagtggca gagactgaca     2280

gaggagcagt gcctgtttag cgcctggctg agcgagaagg aggacgccgt gaacaagatc     2340

cacaccaccg gcttcaagga ccagaacgag atgctgagca gcctgcagaa gctggccgtg     2400

ctgaaggccg atctggagaa gaaaaagcag agcatgggca agctgtactc cctgaagcag     2460

gacctgctgt ccaccctgaa gaacaagagc gtgacccaga aaaccgaggc ctggctggac     2520

aatttcgccc ggtgctggga caatctggtg cagaaactgg agaagagcac cgcccagatc     2580

agccaggccg tgaccaccac ccagcccagc ctgacacaga ccaccgtgat ggagaccgtg     2640

accacagtga ccaccaggga gcagatcctg gtgaagcacg cccaggagga gctgccccct     2700

cccccccctc agaagaagcg gcagatcaca gtggacaccc tggagagact gcaggagctg     2760

caggaagcca ccgacgagct ggacctgaag ctgagacagg ccgaagtgat caagggcagc     2820

tggcagcctg tgggcgatct gctgatcgac agcctgcagg accacctgga gaaagtgaag     2880

gccctgcggg gcgagatcgc ccccctgaag gagaatgtga gccacgtgaa cgacctggcc     2940

agacagctga ccaccctggg catccagctg agcccctaca atctgagcac cctggaagat     3000

ctgaacaccc ggtggaaact gctgcaggtg gccgtggagg atagagtgag gcagctgcac     3060

gaggcccaca gagacttcgg ccctgcctcc cagcacttcc tgagcaccag cgtgcagggc     3120

ccctgggaga gagccatctc ccccaacaaa gtgccctact acatcaacca cgagacccag     3180

accacctgct gggaccaccc taagatgacc gagctgtacc agagcctggc cgacctgaac     3240

aatgtgcggt tcagcgccta cagaaccgcc atgaagctgc ggagactgca gaaggccctg     3300

tgcctggacc tgctgagcct gagcgccgcc tgcgacgccc tggaccagca caacctgaag     3360

cagaacgacc agcccatgga cattctgcag atcatcaact gcctgaccac catctacgat     3420

cggctggagc aggagcacaa caacctggtg aacgtgcccc tgtgcgtgga catgtgcctg     3480

aattggctgc tgaacgtgta cgacaccggc aggaccggca gaatcagagt gctgtccttc     3540

aagaccggca tcatcagcct gtgcaaggcc cacctggagg ataagtaccg ctacctgttc     3600

aagcaggtgg ccagcagcac cggcttctgc gatcagagga gactgggcct gctgctgcac     3660

gatagcatcc agatccctag gcagctgggc gaagtggcca gctttggcgg cagcaacatc     3720

gagccctctg tgaggagctg cttccagttc gccaacaaca agcccgagat cgaggccgcc     3780

ctgttcctgg attggatgag gctggagccc cagagcatgg tgtggctgcc tgtgctgcac     3840

agagtggccg ccgccgagac cgccaagcac caggccaagt gcaacatctg caaggagtgc     3900

cccatcatcg gcttccggta caggagcctg aagcacttca actacgacat ctgccagagc     3960

tgctttttca gcggcagagt ggccaagggc cacaagatgc actaccccat ggtggagtac     4020

tgcaccccca ccacctccgg cgaggatgtg agagacttcg ccaaagtgct gaagaataag     4080

ttccggacca agcggtactt tgccaagcac cccaggatgg gctacctgcc cgtgcagacc     4140

gtgctggagg gcgacaacat ggagaccgac accatgtgat gatgagcggc cgcttccctt     4200

tagtgagggt taatgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc     4260

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta     4320

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg     4380

tttcaggttc agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt     4440

ggtaaaatcc gataaggact agagcatggc tacgtagata agtagcatgg cgggttaatc     4500

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4560

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     4620

gtgagcgagc gagcgcgcag                                                 4640


<210> 2
<211> 4643
<212> DNA
<213> Artificial Sequence

<220> 
<223> AAV_ITR_Spc512-canine MD1

<400> 2
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctag      180

acatggctcg acagatcgag ctccaccgcg gtggcggccg tccgccctcg gcaccatcct      240

cacgacaccc aaatatggcg acgggtgagg aatggtgggg agttattttt agagcggtga      300

ggaaggtggg caggcagcag gtgttggcgc tctaaaaata actcccggga gttattttta      360

gagcggagga atggtggaca cccaaatatg gcgacggttc ctcacccgtc gccatatttg      420

ggtgtccgcc ctcggccggg gccgcattcc tgggggccgg gcggtgctcc cgcccgcctc      480

gataaaaggc tccggggccg gcggcggccc acgagctacc cggaggagcg ggaggcgcca      540

agctctagaa ctagtggatc ccccgggctg caggaattcg ccaccatgct gtggtgggag      600

gaagtggagg actgctacga gagagaggac gtgcagaaga aaaccttcac caagtggatc      660

aacgcccagt tcagcaagtt cggcaagcag cacatcgaga acctgttcag cgatctgcag      720

gatggcagga gactgctgga tctgctggag ggactgaccg gccagaagct gcccaaggag      780

aagggcagca ccagagtgca cgccctgaac aacgtgaaca aggccctgag agtgctgcag      840

aagaacaacg tggacctggt ggatatcggc agcaccgaca tcgtggacgg caaccacaag      900

ctgaccctgg gcctgatctg gaacatcatc ctgcactggc aggtgaagaa cgtgatgaag      960

aacatcatgg ccggcctgca gcagaccaac agcgagaaga tcctgctgag ctgggtgagg     1020

cagagcacca gaaactaccc ccaggtgaac gtgatcaact tcaccacctc ctggagcgac     1080

ggcctggccc tgaacgccct gatccacagc cacagacccg acctgttcga ctggaacagc     1140

gtggtgtgtc agcagagcgc cacccagaga ctggagcacg ccttcaacat cgccaagtac     1200

cagctgggca tcgagaagct gctggacccc gaggacgtgg ccaccaccta ccccgacaag     1260

aaaagcatcc tgatgtatat taccagcctg ttccaggtgc tgccccagca ggtgtccatc     1320

gaggccatcc aggaagtgga aatgctgccc aggcccagca aagtgaccag ggaggagcac     1380

ttccagctgc accaccagat gcactatagc cagcagatca ccgtgtccct ggcccagggc     1440

tatgagagag cccctagcag ccccaagccc cggttcaaga gctacgccta cacccaggcc     1500

gcctacgtga ccacctccga ccccaccaga agccccctgc ccagccagca cctggagacc     1560

cctgaggata agagcttcgg cagaagcctg accgagaccg aggccaacct ggatagctac     1620

cagaccgccc tggaggaagt gctgtcttgg ctgctgtccg ccgaggacgc cctgcaggcc     1680

cagggcgaga tcagcaacga cgtggaagaa gtgaaggagc agttccacac ccacgagggc     1740

tacatgatgg acctgaccag ccaccagggc agagtgggca acgtgctgca gctgggcagc     1800

cagctgatcg gcaccggcaa gctgagcgag gacgaggaga ccgaagtgca ggaacagatg     1860

aacctgctga acagcagatg ggagtgcctg agagtggcca gcatggagaa gcagagcaac     1920

ctgcacaaag tgctgatgga tctgcagaac cagcagctga aggagctgaa cgactggctg     1980

accaagacag aggagcggac ccggaagatg gagaaggagc ccctgggccc tgacatcgag     2040

gacctgaaga ggcaggtgca gcagcataag gtcctgcagg aggatctgga gcaggagcag     2100

gtgcgcgtga acagcctgac ccacatggtg gtcgtggtgg acgagagcag cggcgaccac     2160

gccacagccg ccctggaaga gcagctgaaa gtgctgggcg gcagatgggc caatatctgc     2220

cggtggaccg aggacagatg ggtgctgctg caggacatcc tgctgaagtg gcagagattc     2280

accgaggagc agtgcctgtt tagcgcctgg ctgagcgaga aggaggacgc cgtgaacaag     2340

atccacacca ccggcttcaa ggaccagagc gaagtgctgt ccaacctgca gaagctggcc     2400

gtgctgaaaa ccgacctgga gaagaaaaag cagaccatgg acaagctgtg cagcctgaac     2460

caggacctgc tgagcgccct gaagaacacc gtggtggccc acaagatgga ggcctggctg     2520

gataatagcg ctcagagatg ggataatctg gtgcagaaac tggagaagag cagcgcccag     2580

atcagccagg ccgtgaccac cacccagccc agcctgacac agaccaccgt gatggagacc     2640

gtgaccatgg tgaccaccag ggagcacatc ctggtgaagc acgcccagga ggagctgccc     2700

cctccccccc ctcagaagaa gcggcagatc atcgtggatg ccctggagag actgcaggag     2760

ctgcaggaag ccaccgacga gctggacctg aagctgagac aggccgaagt gatcaagggc     2820

agctggcagc ctgtgggcga tctgctgatc gacagcctgc aggaccacct ggagaaagtg     2880

aaggccctgc ggggcgagac cacccccctg aaggagaacg tgtcctacgt gaacgacctg     2940

gccagacagc tgaccaccct gggcattcag ctgagcccct acaacctgaa caccctggag     3000

gatctgaaca cccggtggaa actgctgcag gtggccattg aggaccggat caggcagctg     3060

cacgaggccc acagagactt cggccctgct tctcagcatt tcctgagcac cagcgtgcag     3120

ggcccctggg agagagccat cagccccaac aaagtgccct actacatcaa ccacgagacc     3180

cagaccacct gctgggacca ccctaagatg accgagctgt accagagcct ggccgacctg     3240

aacaatgtgc ggttcagcgc ctacagaacc gccatgaagc tgcggagact gcagaaggcc     3300

ctgtgcctgg acctgctgtc cctgagcgcc gcctgcgacg ccctggacca gcacaacctg     3360

aagcagaacg accagcccat ggatatcctg caggtgatca actgcctgac caccatctac     3420

gatcggctgg agcaggagca caacaacctg gtgaacgtgc ccctgtgcgt ggacatgtgc     3480

ctgaattggc tgctgaacgt gtacgacacc ggcaggaccg gcagaatcag agtgctgtcc     3540

ttcaagaccg gcatcatcag cctgtgcaag gcccacctgg aggataagta ccgctacctg     3600

ttcaagcagg tggccagcag caccggcttc tgcgatcaga ggagactggg cctgctgctg     3660

cacgatagca tccagatccc taggcagctg ggcgaagtgg ccagctttgg cggcagcaac     3720

atcgagccct ctgtgaggag ctgcttccag ttcgccaaca acaagcccga gatcgaggcc     3780

gccctgttcc tggattggat gaggctggag ccccagagca tggtgtggct gcctgtgctg     3840

cacagagtgg ccgccgccga gaccgccaag caccaggcca agtgcaacat ctgcaaggag     3900

tgccccatca tcggcttccg gtacaggagc ctgaagcact tcaactacga catctgccag     3960

agctgctttt tcagcggcag agtggccaag ggccacaaga tgcactaccc catggtggag     4020

tactgcaccc ccaccacctc cggcgaggat gtgagagact tcgccaaagt gctgaagaat     4080

aagttccgga ccaagcggta ctttgccaag caccccagga tgggctacct gcccgtgcag     4140

accgtgctgg agggcgacaa catggagacc gacaccatgt gatgatgagc ggccgcttcc     4200

ctttagtgag ggttaatgct tcgagcagac atgataagat acattgatga gtttggacaa     4260

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct     4320

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     4380

atgtttcagg ttcaggggga gatgtgggag gttttttaaa gcaagtaaaa cctctacaaa     4440

tgtggtaaaa tccgataagg actagagcat ggctacgtag ataagtagca tggcgggtta     4500

atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4560

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4620

tcagtgagcg agcgagcgcg cag                                             4643


<210> 3
<211> 1197
<212> PRT
<213> Artificial Sequence

<220> 
<223> human MD1

<400> 3
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Thr Leu Glu 
705                 710                 715                 720 
Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu 
                725                 730                 735     
Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu 
            740                 745                 750         
Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg 
        755                 760                 765             
Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu 
    770                 775                 780                 
Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu 
785                 790                 795                 800 
Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala 
                805                 810                 815     
Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly 
            820                 825                 830         
Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu 
        835                 840                 845             
Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr 
    850                 855                 860                 
Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser 
865                 870                 875                 880 
Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met 
                885                 890                 895     
Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu 
            900                 905                 910         
Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp 
        915                 920                 925             
Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr 
    930                 935                 940                 
Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys 
945                 950                 955                 960 
Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg 
                965                 970                 975     
Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu 
            980                 985                 990         
Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val 
        995                 1000                1005            
Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu 
    1010                1015                1020                
His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe 
1025                1030                1035                1040
Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala 
                1045                1050                1055    
Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg 
            1060                1065                1070        
Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala 
        1075                1080                1085            
Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu 
    1090                1095                1100                
Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr 
1105                1110                1115                1120
Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His 
                1125                1130                1135    
Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly 
            1140                1145                1150        
Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr 
        1155                1160                1165            
Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln 
    1170                1175                1180                
Thr Val Leu Glu Gly Asp Asn Met Glu Thr Asp Thr Met 
1185                1190                1195        

<210> 4
<211> 1198
<212> PRT
<213> Artificial Sequence

<220> 
<223> canine MD1

<400> 4
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Lys Asn Asn Val Asp Leu Val Asp Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Lys Tyr Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Pro Ser Lys Val Thr Arg Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             
Ala Pro Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln 
    290                 295                 300                 
Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Leu Pro Ser 
305                 310                 315                 320 
Gln His Leu Glu Thr Pro Glu Asp Lys Ser Phe Gly Arg Ser Leu Thr 
                325                 330                 335     
Glu Thr Glu Ala Asn Leu Asp Ser Tyr Gln Thr Ala Leu Glu Glu Val 
            340                 345                 350         
Leu Ser Trp Leu Leu Ser Ala Glu Asp Ala Leu Gln Ala Gln Gly Glu 
        355                 360                 365             
Ile Ser Asn Asp Val Glu Glu Val Lys Glu Gln Phe His Thr His Glu 
    370                 375                 380                 
Gly Tyr Met Met Asp Leu Thr Ser His Gln Gly Arg Val Gly Asn Val 
385                 390                 395                 400 
Leu Gln Leu Gly Ser Gln Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp 
                405                 410                 415     
Glu Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp 
            420                 425                 430         
Glu Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Lys 
        435                 440                 445             
Val Leu Met Asp Leu Gln Asn Gln Gln Leu Lys Glu Leu Asn Asp Trp 
    450                 455                 460                 
Leu Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Lys Glu Pro Leu 
465                 470                 475                 480 
Gly Pro Asp Ile Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val 
                485                 490                 495     
Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr 
            500                 505                 510         
His Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala 
        515                 520                 525             
Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Gly Arg Trp Ala Asn Ile 
    530                 535                 540                 
Cys Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu 
545                 550                 555                 560 
Lys Trp Gln Arg Phe Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu 
                565                 570                 575     
Ser Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys 
            580                 585                 590         
Asp Gln Ser Glu Val Leu Ser Asn Leu Gln Lys Leu Ala Val Leu Lys 
        595                 600                 605             
Thr Asp Leu Glu Lys Lys Lys Gln Thr Met Asp Lys Leu Cys Ser Leu 
    610                 615                 620                 
Asn Gln Asp Leu Leu Ser Ala Leu Lys Asn Thr Val Val Ala His Lys 
625                 630                 635                 640 
Met Glu Ala Trp Leu Asp Asn Ser Ala Gln Arg Trp Asp Asn Leu Val 
                645                 650                 655     
Gln Lys Leu Glu Lys Ser Ser Ala Gln Ile Ser Gln Ala Val Thr Thr 
            660                 665                 670         
Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Met 
        675                 680                 685             
Val Thr Thr Arg Glu His Ile Leu Val Lys His Ala Gln Glu Glu Leu 
    690                 695                 700                 
Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Ile Val Asp Ala Leu 
705                 710                 715                 720 
Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys 
                725                 730                 735     
Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp 
            740                 745                 750         
Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu 
        755                 760                 765             
Arg Gly Glu Thr Thr Pro Leu Lys Glu Asn Val Ser Tyr Val Asn Asp 
    770                 775                 780                 
Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn 
785                 790                 795                 800 
Leu Asn Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val 
                805                 810                 815     
Ala Ile Glu Asp Arg Ile Arg Gln Leu His Glu Ala His Arg Asp Phe 
            820                 825                 830         
Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp 
        835                 840                 845             
Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu 
    850                 855                 860                 
Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln 
865                 870                 875                 880 
Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala 
                885                 890                 895     
Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser 
            900                 905                 910         
Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn 
        915                 920                 925             
Asp Gln Pro Met Asp Ile Leu Gln Val Ile Asn Cys Leu Thr Thr Ile 
    930                 935                 940                 
Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu 
945                 950                 955                 960 
Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly 
                965                 970                 975     
Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser 
            980                 985                 990         
Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln 
        995                 1000                1005            
Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu 
    1010                1015                1020                
Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser 
1025                1030                1035                1040
Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe 
                1045                1050                1055    
Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met 
            1060                1065                1070        
Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val 
        1075                1080                1085            
Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys 
    1090                1095                1100                
Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn 
1105                1110                1115                1120
Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly 
                1125                1130                1135    
His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser 
            1140                1145                1150        
Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg 
        1155                1160                1165            
Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val 
    1170                1175                1180                
Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr Asp Thr Met 
1185                1190                1195            

<210> 5
<211> 3600
<212> DNA
<213> Artificial Sequence

<220> 
<223> opt human MD1

<400> 5
atgctgtggt gggaggaagt ggaggactgc tacgagagag aggacgtgca gaagaaaacc       60

ttcaccaagt gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggatgg caggagactg ctggatctgc tggagggact gaccggccag      180

aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caacgtggac ctggtgaata tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtg      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat caacttcacc      480

acctcctgga gcgacggcct ggccctgaac gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtggt gtgtcagcag agcgccaccc agagactgga gcacgccttc      600

aacatcgcca gataccagct gggcatcgag aagctgctgg accccgagga cgtggacacc      660

acctaccccg acaagaaaag catcctgatg tatattacct ctctgtttca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccaggcc ccccaaagtg      780

accaaggagg agcacttcca gctgcaccac cagatgcact atagccagca gatcaccgtg      840

tccctggccc agggctatga gagaaccagc agccccaagc ccagattcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccacctcc gaccccacca gaagcccctt ccccagccag      960

cacctggagg cccccgagga caagagcttc ggcagcagcc tgatggagag cgaagtgaac     1020

ctggacagat accagaccgc cctggaggaa gtgctgtctt ggctgctgtc cgccgaggac     1080

accctgcagg cccagggcga gatcagcaac gacgtggaag tggtgaagga ccagttccac     1140

acccacgagg gctacatgat ggatctgacc gcccaccagg gcagagtggg caatatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgagga gaccgaagtg     1260

caggagcaga tgaacctgct gaacagcaga tgggagtgcc tgagagtggc cagcatggag     1320

aagcagagca acctgcaccg cgtgctgatg gacctgcaga accagaagct gaaggagctg     1380

aacgactggc tgaccaagac cgaggagcgg accagaaaga tggaggagga gcccctgggc     1440

cccgacctgg aggacctgaa gagacaggtg cagcagcaca aagtgctgca ggaggacctg     1500

gaacaggagc aggtgcgcgt gaacagcctg acccacatgg tggtcgtggt ggacgagagc     1560

agcggcgacc acgccacagc cgccctggaa gagcagctga aagtgctggg cgacagatgg     1620

gccaacatct gccggtggac cgaggacaga tgggtgctgc tgcaggacat cctgctgaag     1680

tggcagagac tgacagagga gcagtgcctg tttagcgcct ggctgagcga gaaggaggac     1740

gccgtgaaca agatccacac caccggcttc aaggaccaga acgagatgct gagcagcctg     1800

cagaagctgg ccgtgctgaa ggccgatctg gagaagaaaa agcagagcat gggcaagctg     1860

tactccctga agcaggacct gctgtccacc ctgaagaaca agagcgtgac ccagaaaacc     1920

gaggcctggc tggacaattt cgcccggtgc tgggacaatc tggtgcagaa actggagaag     1980

agcaccgccc agatcagcca ggccgtgacc accacccagc ccagcctgac acagaccacc     2040

gtgatggaga ccgtgaccac agtgaccacc agggagcaga tcctggtgaa gcacgcccag     2100

gaggagctgc cccctccccc ccctcagaag aagcggcaga tcacagtgga caccctggag     2160

agactgcagg agctgcagga agccaccgac gagctggacc tgaagctgag acaggccgaa     2220

gtgatcaagg gcagctggca gcctgtgggc gatctgctga tcgacagcct gcaggaccac     2280

ctggagaaag tgaaggccct gcggggcgag atcgcccccc tgaaggagaa tgtgagccac     2340

gtgaacgacc tggccagaca gctgaccacc ctgggcatcc agctgagccc ctacaatctg     2400

agcaccctgg aagatctgaa cacccggtgg aaactgctgc aggtggccgt ggaggataga     2460

gtgaggcagc tgcacgaggc ccacagagac ttcggccctg cctcccagca cttcctgagc     2520

accagcgtgc agggcccctg ggagagagcc atctccccca acaaagtgcc ctactacatc     2580

aaccacgaga cccagaccac ctgctgggac caccctaaga tgaccgagct gtaccagagc     2640

ctggccgacc tgaacaatgt gcggttcagc gcctacagaa ccgccatgaa gctgcggaga     2700

ctgcagaagg ccctgtgcct ggacctgctg agcctgagcg ccgcctgcga cgccctggac     2760

cagcacaacc tgaagcagaa cgaccagccc atggacattc tgcagatcat caactgcctg     2820

accaccatct acgatcggct ggagcaggag cacaacaacc tggtgaacgt gcccctgtgc     2880

gtggacatgt gcctgaattg gctgctgaac gtgtacgaca ccggcaggac cggcagaatc     2940

agagtgctgt ccttcaagac cggcatcatc agcctgtgca aggcccacct ggaggataag     3000

taccgctacc tgttcaagca ggtggccagc agcaccggct tctgcgatca gaggagactg     3060

ggcctgctgc tgcacgatag catccagatc cctaggcagc tgggcgaagt ggccagcttt     3120

ggcggcagca acatcgagcc ctctgtgagg agctgcttcc agttcgccaa caacaagccc     3180

gagatcgagg ccgccctgtt cctggattgg atgaggctgg agccccagag catggtgtgg     3240

ctgcctgtgc tgcacagagt ggccgccgcc gagaccgcca agcaccaggc caagtgcaac     3300

atctgcaagg agtgccccat catcggcttc cggtacagga gcctgaagca cttcaactac     3360

gacatctgcc agagctgctt tttcagcggc agagtggcca agggccacaa gatgcactac     3420

cccatggtgg agtactgcac ccccaccacc tccggcgagg atgtgagaga cttcgccaaa     3480

gtgctgaaga ataagttccg gaccaagcgg tactttgcca agcaccccag gatgggctac     3540

ctgcccgtgc agaccgtgct ggagggcgac aacatggaga ccgacaccat gtgatgatga     3600


<210> 6
<211> 3603
<212> DNA
<213> Artificial Sequence

<220> 
<223> opt canine MD1

<400> 6
atgctgtggt gggaggaagt ggaggactgc tacgagagag aggacgtgca gaagaaaacc       60

ttcaccaagt ggatcaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgatc tgcaggatgg caggagactg ctggatctgc tggagggact gaccggccag      180

aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagagtgc tgcagaagaa caacgtggac ctggtggata tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtg      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat caacttcacc      480

acctcctgga gcgacggcct ggccctgaac gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtggt gtgtcagcag agcgccaccc agagactgga gcacgccttc      600

aacatcgcca agtaccagct gggcatcgag aagctgctgg accccgagga cgtggccacc      660

acctaccccg acaagaaaag catcctgatg tatattacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccaggcc cagcaaagtg      780

accagggagg agcacttcca gctgcaccac cagatgcact atagccagca gatcaccgtg      840

tccctggccc agggctatga gagagcccct agcagcccca agccccggtt caagagctac      900

gcctacaccc aggccgccta cgtgaccacc tccgacccca ccagaagccc cctgcccagc      960

cagcacctgg agacccctga ggataagagc ttcggcagaa gcctgaccga gaccgaggcc     1020

aacctggata gctaccagac cgccctggag gaagtgctgt cttggctgct gtccgccgag     1080

gacgccctgc aggcccaggg cgagatcagc aacgacgtgg aagaagtgaa ggagcagttc     1140

cacacccacg agggctacat gatggacctg accagccacc agggcagagt gggcaacgtg     1200

ctgcagctgg gcagccagct gatcggcacc ggcaagctga gcgaggacga ggagaccgaa     1260

gtgcaggaac agatgaacct gctgaacagc agatgggagt gcctgagagt ggccagcatg     1320

gagaagcaga gcaacctgca caaagtgctg atggatctgc agaaccagca gctgaaggag     1380

ctgaacgact ggctgaccaa gacagaggag cggacccgga agatggagaa ggagcccctg     1440

ggccctgaca tcgaggacct gaagaggcag gtgcagcagc ataaggtcct gcaggaggat     1500

ctggagcagg agcaggtgcg cgtgaacagc ctgacccaca tggtggtcgt ggtggacgag     1560

agcagcggcg accacgccac agccgccctg gaagagcagc tgaaagtgct gggcggcaga     1620

tgggccaata tctgccggtg gaccgaggac agatgggtgc tgctgcagga catcctgctg     1680

aagtggcaga gattcaccga ggagcagtgc ctgtttagcg cctggctgag cgagaaggag     1740

gacgccgtga acaagatcca caccaccggc ttcaaggacc agagcgaagt gctgtccaac     1800

ctgcagaagc tggccgtgct gaaaaccgac ctggagaaga aaaagcagac catggacaag     1860

ctgtgcagcc tgaaccagga cctgctgagc gccctgaaga acaccgtggt ggcccacaag     1920

atggaggcct ggctggataa tagcgctcag agatgggata atctggtgca gaaactggag     1980

aagagcagcg cccagatcag ccaggccgtg accaccaccc agcccagcct gacacagacc     2040

accgtgatgg agaccgtgac catggtgacc accagggagc acatcctggt gaagcacgcc     2100

caggaggagc tgccccctcc cccccctcag aagaagcggc agatcatcgt ggatgccctg     2160

gagagactgc aggagctgca ggaagccacc gacgagctgg acctgaagct gagacaggcc     2220

gaagtgatca agggcagctg gcagcctgtg ggcgatctgc tgatcgacag cctgcaggac     2280

cacctggaga aagtgaaggc cctgcggggc gagaccaccc ccctgaagga gaacgtgtcc     2340

tacgtgaacg acctggccag acagctgacc accctgggca ttcagctgag cccctacaac     2400

ctgaacaccc tggaggatct gaacacccgg tggaaactgc tgcaggtggc cattgaggac     2460

cggatcaggc agctgcacga ggcccacaga gacttcggcc ctgcttctca gcatttcctg     2520

agcaccagcg tgcagggccc ctgggagaga gccatcagcc ccaacaaagt gccctactac     2580

atcaaccacg agacccagac cacctgctgg gaccacccta agatgaccga gctgtaccag     2640

agcctggccg acctgaacaa tgtgcggttc agcgcctaca gaaccgccat gaagctgcgg     2700

agactgcaga aggccctgtg cctggacctg ctgtccctga gcgccgcctg cgacgccctg     2760

gaccagcaca acctgaagca gaacgaccag cccatggata tcctgcaggt gatcaactgc     2820

ctgaccacca tctacgatcg gctggagcag gagcacaaca acctggtgaa cgtgcccctg     2880

tgcgtggaca tgtgcctgaa ttggctgctg aacgtgtacg acaccggcag gaccggcaga     2940

atcagagtgc tgtccttcaa gaccggcatc atcagcctgt gcaaggccca cctggaggat     3000

aagtaccgct acctgttcaa gcaggtggcc agcagcaccg gcttctgcga tcagaggaga     3060

ctgggcctgc tgctgcacga tagcatccag atccctaggc agctgggcga agtggccagc     3120

tttggcggca gcaacatcga gccctctgtg aggagctgct tccagttcgc caacaacaag     3180

cccgagatcg aggccgccct gttcctggat tggatgaggc tggagcccca gagcatggtg     3240

tggctgcctg tgctgcacag agtggccgcc gccgagaccg ccaagcacca ggccaagtgc     3300

aacatctgca aggagtgccc catcatcggc ttccggtaca ggagcctgaa gcacttcaac     3360

tacgacatct gccagagctg ctttttcagc ggcagagtgg ccaagggcca caagatgcac     3420

taccccatgg tggagtactg cacccccacc acctccggcg aggatgtgag agacttcgcc     3480

aaagtgctga agaataagtt ccggaccaag cggtactttg ccaagcaccc caggatgggc     3540

tacctgcccg tgcagaccgt gctggagggc gacaacatgg agaccgacac catgtgatga     3600

tga                                                                   3603


<210> 7
<211> 1199
<212> PRT
<213> Artificial Sequence

<220> 
<223> murine MD1

<400> 7
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          
Gly Lys Gln His Ile Asp Asn Leu Phe Ser Asp Leu Gln Asp Gly Lys 
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  
Leu Arg Val Leu Gln Lys Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Thr Ile Met 
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 
Ser Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Ser Gln His Ser Ala 
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Lys Cys Gln Leu Gly 
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Thr Thr Tyr Pro Asp 
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     
Thr Ser Ser Lys Val Thr Arg Glu Glu His Phe Gln Leu His His Gln 
            260                 265                 270         
Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu 
        275                 280                 285             
Gln Thr Ser Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Phe Thr 
    290                 295                 300                 
Gln Ala Ala Tyr Val Ala Thr Ser Asp Ser Thr Gln Ser Pro Tyr Pro 
305                 310                 315                 320 
Ser Gln His Leu Glu Ala Pro Arg Asp Lys Ser Leu Asp Ser Ser Leu 
                325                 330                 335     
Met Glu Thr Glu Val Asn Leu Asp Ser Tyr Gln Thr Ala Leu Glu Glu 
            340                 345                 350         
Val Leu Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Arg Ala Gln Gly 
        355                 360                 365             
Glu Ile Ser Asn Asp Val Glu Glu Val Lys Glu Gln Phe His Ala His 
    370                 375                 380                 
Glu Gly Phe Met Met Asp Leu Thr Ser His Gln Gly Leu Val Gly Asn 
385                 390                 395                 400 
Val Leu Gln Leu Gly Ser Gln Leu Val Gly Lys Gly Lys Leu Ser Glu 
                405                 410                 415     
Asp Glu Glu Ala Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg 
            420                 425                 430         
Trp Glu Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Lys Leu His 
        435                 440                 445             
Lys Val Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asp Asp 
    450                 455                 460                 
Trp Leu Thr Lys Thr Glu Glu Arg Thr Lys Lys Met Glu Glu Glu Pro 
465                 470                 475                 480 
Phe Gly Pro Asp Leu Glu Asp Leu Lys Cys Gln Val Gln Gln His Lys 
                485                 490                 495     
Val Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu 
            500                 505                 510         
Thr His Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr 
        515                 520                 525             
Ala Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn 
    530                 535                 540                 
Ile Cys Arg Trp Thr Glu Asp Arg Trp Ile Val Leu Gln Asp Ile Leu 
545                 550                 555                 560 
Leu Lys Trp Gln His Phe Thr Glu Glu Gln Cys Leu Phe Ser Thr Trp 
                565                 570                 575     
Leu Ser Glu Lys Glu Asp Ala Met Lys Asn Ile Gln Thr Ser Gly Phe 
            580                 585                 590         
Lys Asp Gln Asn Glu Met Met Ser Ser Leu His Lys Ile Ser Thr Leu 
        595                 600                 605             
Lys Ile Asp Leu Glu Lys Lys Lys Pro Thr Met Glu Lys Leu Ser Ser 
    610                 615                 620                 
Leu Asn Gln Asp Leu Leu Ser Ala Leu Lys Asn Lys Ser Val Thr Gln 
625                 630                 635                 640 
Lys Met Glu Ile Trp Met Glu Asn Phe Ala Gln Arg Trp Asp Asn Leu 
                645                 650                 655     
Thr Gln Lys Leu Glu Lys Ser Ser Ala Gln Ile Ser Gln Ala Val Thr 
            660                 665                 670         
Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr 
        675                 680                 685             
Met Val Thr Thr Arg Glu Gln Ile Met Val Lys His Ala Gln Glu Glu 
    690                 695                 700                 
Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ala 
705                 710                 715                 720 
Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Ala Asp Glu Leu Asp Leu 
                725                 730                 735     
Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly 
            740                 745                 750         
Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala 
        755                 760                 765             
Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Asn Arg Val Asn 
    770                 775                 780                 
Asp Leu Ala His Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr 
785                 790                 795                 800 
Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Arg Leu Leu Gln 
                805                 810                 815     
Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp 
            820                 825                 830         
Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro 
        835                 840                 845             
Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His 
    850                 855                 860                 
Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr 
865                 870                 875                 880 
Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr 
                885                 890                 895     
Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu 
            900                 905                 910         
Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln 
        915                 920                 925             
Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr 
    930                 935                 940                 
Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro 
945                 950                 955                 960 
Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr 
                965                 970                 975     
Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile 
            980                 985                 990         
Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys 
        995                 1000                1005            
Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu 
    1010                1015                1020                
Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala 
1025                1030                1035                1040
Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln 
                1045                1050                1055    
Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp 
            1060                1065                1070        
Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg 
        1075                1080                1085            
Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys 
    1090                1095                1100                
Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe 
1105                1110                1115                1120
Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys 
                1125                1130                1135    
Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr 
            1140                1145                1150        
Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe 
        1155                1160                1165            
Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro 
    1170                1175                1180                
Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr Asp Thr Met 
1185                1190                1195                

<210> 8
<211> 3611
<212> DNA
<213> Artificial Sequence

<220> 
<223> opt murine MD1

<400> 8
atgctgtggt gggaggaagt ggaggactgc tacgagagag aggacgtgca gaagaaaacc       60

ttcaccaagt ggatcaacgc ccagttcagc aagttcggca agcagcacat cgacaacctg      120

ttcagcgacc tgcaggacgg caagagactg ctggatctgc tggagggact gaccggccag      180

aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagagtgc tgcagaagaa caacgtggac ctggtgaata tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtg      360

aagaacgtga tgaaaaccat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat caacttcacc      480

agcagctgga gcgacggcct ggccctgaac gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtggt gtcccagcac agcgccaccc agagactgga gcacgccttc      600

aacatcgcca agtgccagct gggcatcgag aagctgctgg accccgagga cgtggccacc      660

acctaccccg acaagaaaag catcctcatg tatatcacct ctctgtttca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgccccggac cagcagcaaa      780

gtgacccggg aggagcactt ccagctgcac caccagatgc actatagcca gcagatcacc      840

gtgtccctgg cccagggcta cgagcagacc agcagctccc ccaagcccag attcaagagc      900

tacgccttca cccaggccgc ctacgtggcc acaagcgata gcacccagag cccctacccc      960

agccagcacc tggaggcccc tagagacaag agcctggaca gcagcctgat ggagacagaa     1020

gtgaacctgg acagctacca gaccgccctg gaggaagtgc tgtcttggct gctgtccgcc     1080

gaggacaccc tgagagccca gggcgagatc agcaacgacg tggaagaagt gaaggagcag     1140

ttccacgccc acgagggctt catgatggac ctgacctccc atcagggcct ggtgggcaac     1200

gtgctgcagc tgggcagcca gctcgtggga aagggcaagc tgagcgagga cgaggaggcc     1260

gaagtgcagg aacagatgaa cctgctgaac agcagatggg agtgcctgag agtggccagc     1320

atggagaagc agagcaagct gcacaaagtg ctgatggatc tgcagaacca gaagctgaag     1380

gaactggacg actggctgac caagaccgag gagcggacca agaagatgga ggaggagccc     1440

ttcggccccg acctggagga cctgaagtgc caggtgcagc agcataaggt cctgcaggag     1500

gacctggaac aggagcaggt gcgcgtgaac agcctgaccc acatggtggt cgtggtggac     1560

gagagcagcg gcgaccacgc cacagccgcc ctggaagagc agctgaaagt gctgggcgac     1620

agatgggcca atatctgccg gtggaccgag gatagatgga tcgtgctgca ggacatcctg     1680

ctgaagtggc agcacttcac cgaggagcag tgcctgttta gcacctggct gagcgagaaa     1740

gaggacgcca tgaagaacat ccagaccagc ggcttcaagg accagaacga gatgatgagc     1800

agcctgcaca agatcagcac cctgaagatc gacctggaga agaaaaagcc cacaatggag     1860

aagctgtcca gcctgaacca ggacctgctg agcgccctga agaacaagag cgtgacccag     1920

aaaatggaga tctggatgga gaatttcgca cagaggtggg acaacctgac ccagaagctg     1980

gagaagagca gcgcccagat cagccaggcc gtgaccacca cccagcccag cctgacacag     2040

accaccgtga tggagaccgt gaccatggtg accacccggg agcagatcat ggtgaagcac     2100

gcccaggagg agctgccccc tcccccccct cagaagaagc ggcagatcac agtggatgcc     2160

ctggagagac tgcaggagct gcaggaagcc gccgacgagc tggatctgaa gctgagacag     2220

gccgaagtga tcaagggcag ctggcagcct gtgggcgatc tgctgatcga cagcctgcag     2280

gaccacctgg agaaagtgaa ggccctgcgg ggcgagatcg cccccctgaa ggagaacgtg     2340

aaccgcgtga acgacctggc ccatcagctg accaccctgg gcattcagct gagcccctac     2400

aacctgagca ccctggagga tctgaacacc cggtggagac tgctgcaggt ggccgtggag     2460

gatagagtga ggcagctgca cgaggcccac agagacttcg gccctgcctc ccagcacttc     2520

ctgagcacca gcgtgcaggg cccctgggag agagccatca gccccaacaa agtgccctac     2580

tacatcaacc acgagaccca gaccacctgc tgggaccacc ctaagatgac cgagctgtac     2640

cagagcctgg ccgacctgaa caatgtgcgg ttcagcgcct acagaaccgc catgaagctg     2700

cggagactgc agaaggccct gtgcctggac ctgctgtccc tgagcgccgc ctgcgacgcc     2760

ctggaccagc acaacctgaa gcagaacgac cagcccatgg atatcctgca gatcatcaac     2820

tgcctgacca ccatctacga tcggctggag caggagcaca acaacctggt gaacgtgccc     2880

ctgtgcgtgg acatgtgcct gaattggctg ctgaacgtgt acgacaccgg caggaccggc     2940

agaatcagag tgctgtcctt caagaccggc atcatcagcc tgtgcaaggc ccacctggag     3000

gataagtacc gctacctgtt caagcaggtg gccagcagca ccggcttctg cgatcagagg     3060

agactgggcc tgctgctgca cgatagcatc cagatcccta ggcagctggg cgaagtggcc     3120

agctttggcg gcagcaacat cgagccctct gtgaggagct gcttccagtt cgccaacaac     3180

aagcccgaga tcgaggccgc cctgttcctg gattggatga ggctggagcc ccagagcatg     3240

gtgtggctgc ctgtgctgca cagagtggcc gccgccgaga ccgccaagca ccaggccaag     3300

tgcaacatct gcaaggagtg ccccatcatc ggcttccggt acaggagcct gaagcacttc     3360

aactacgaca tctgccagag ctgctttttc agcggcagag tggccaaggg ccacaagatg     3420

cactacccca tggtggagta ctgcaccccc accacctccg gcgaggatgt gagagacttc     3480

gccaaagtgc tgaagaataa gttccggacc aagcggtact ttgccaagca ccccaggatg     3540

ggctacctgc ccgtgcagac cgtgctggag ggcgacaaca tggagaccga caccatgtga     3600

tgtgatgatg a                                                          3611


