                         SEQUENCE LISTING

<110>  Moderna Therapeutics, Inc.
 
<120>  ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

<130>  50858-022WO2

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  784
<212>  DNA
<213>  Homo sapiens

<400>  1
gggagatcag agagaaaaga agagtaagaa gaaatataag agccaccatg gccggtcccg       60

cgacccaaag ccccatgaaa cttatggccc tgcagttgct gctttggcac tcggccctct      120

ggacagtcca agaagcgact cctctcggac ctgcctcatc gttgccgcag tcattccttt      180

tgaagtgtct ggagcaggtg cgaaagattc agggcgatgg agccgcactc caagagaagc      240

tctgcgcgac atacaaactt tgccatcccg aggagctcgt actgctcggg cacagcttgg      300

ggattccctg ggctcctctc tcgtcctgtc cgtcgcaggc tttgcagttg gcagggtgcc      360

tttcccagct ccactccggt ttgttcttgt atcagggact gctgcaagcc cttgagggaa      420

tctcgccaga attgggcccg acgctggaca cgttgcagct cgacgtggcg gatttcgcaa      480

caaccatctg gcagcagatg gaggaactgg ggatggcacc cgcgctgcag cccacgcagg      540

gggcaatgcc ggcctttgcg tccgcgtttc agcgcagggc gggtggagtc ctcgtagcga      600

gccaccttca atcatttttg gaagtctcgt accgggtgct gagacatctt gcgcagccgt      660

gataataggc tggagcctcg gtggccatgc ttcttgcccc ttgggcctcc ccccagcccc      720

tcctcccctt cctgcacccg tacccccgtg gtctttgaat aaagtctgag tgggcggctc      780

taga                                                                   784


<210>  2
<211>  784
<212>  RNA
<213>  Homo sapiens

<400>  2
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccggucccg       60

cgacccaaag ccccaugaaa cuuauggccc ugcaguugcu gcuuuggcac ucggcccucu      120

ggacagucca agaagcgacu ccucucggac cugccucauc guugccgcag ucauuccuuu      180

ugaagugucu ggagcaggug cgaaagauuc agggcgaugg agccgcacuc caagagaagc      240

ucugcgcgac auacaaacuu ugccaucccg aggagcucgu acugcucggg cacagcuugg      300

ggauucccug ggcuccucuc ucguccuguc cgucgcaggc uuugcaguug gcagggugcc      360

uuucccagcu ccacuccggu uuguucuugu aucagggacu gcugcaagcc cuugagggaa      420

ucucgccaga auugggcccg acgcuggaca cguugcagcu cgacguggcg gauuucgcaa      480

caaccaucug gcagcagaug gaggaacugg ggauggcacc cgcgcugcag cccacgcagg      540

gggcaaugcc ggccuuugcg uccgcguuuc agcgcagggc ggguggaguc cucguagcga      600

gccaccuuca aucauuuuug gaagucucgu accgggugcu gagacaucuu gcgcagccgu      660

gauaauaggc uggagccucg guggccaugc uucuugcccc uugggccucc ccccagcccc      720

uccuccccuu ccugcacccg uacccccgug gucuuugaau aaagucugag ugggcggcuc      780

uaga                                                                   784


<210>  3
<211>  1822
<212>  DNA
<213>  Homo sapiens

<400>  3
gggaaataag agagaaaaga agagtaagaa gaaatataag agccaccatg gaagatgcga       60

agaacatcaa gaagggacct gccccgtttt accctttgga ggacggtaca gcaggagaac      120

agctccacaa ggcgatgaaa cgctacgccc tggtccccgg aacgattgcg tttaccgatg      180

cacatattga ggtagacatc acatacgcag aatacttcga aatgtcggtg aggctggcgg      240

aagcgatgaa gagatatggt cttaacacta atcaccgcat cgtggtgtgt tcggagaact      300

cattgcagtt tttcatgccg gtccttggag cacttttcat cggggtcgca gtcgcgccag      360

cgaacgacat ctacaatgag cgggaactct tgaatagcat gggaatctcc cagccgacgg      420

tcgtgtttgt ctccaaaaag gggctgcaga aaatcctcaa cgtgcagaag aagctcccca      480

ttattcaaaa gatcatcatt atggatagca agacagatta ccaagggttc cagtcgatgt      540

atacctttgt gacatcgcat ttgccgccag ggtttaacga gtatgacttc gtccccgagt      600

catttgacag agataaaacc atcgcgctga ttatgaattc ctcgggtagc accggtttgc      660

caaagggggt ggcgttgccc caccgcactg cttgtgtgcg gttctcgcac gctagggatc      720

ctatctttgg taatcagatc attcccgaca cagcaatcct gtccgtggta ccttttcatc      780

acggttttgg catgttcacg actctcggct atttgatttg cggtttcagg gtcgtactta      840

tgtatcggtt cgaggaagaa ctgtttttga gatccttgca agattacaag atccagtcgg      900

ccctccttgt gccaacgctt ttctcattct ttgcgaaatc gacacttatt gataagtatg      960

acctttccaa tctgcatgag attgcctcag ggggagcgcc gcttagcaag gaagtcgggg     1020

aggcagtggc caagcgcttc caccttcccg gaattcggca gggatacggg ctcacggaga     1080

caacatccgc gatccttatc acgcccgagg gtgacgataa gccgggagcc gtcggaaaag     1140

tggtcccctt ctttgaagcc aaggtcgtag acctcgacac gggaaaaacc ctcggagtga     1200

accagagggg cgagctctgc gtgagagggc cgatgatcat gtcaggttac gtgaataacc     1260

ctgaagcgac gaatgcgctg atcgacaagg atgggtggtt gcattcggga gacattgcct     1320

attgggatga ggatgagcac ttctttatcg tagatcgact taagagcttg atcaaataca     1380

aaggctatca ggtagcgcct gccgagctcg agtcaatcct gctccagcac cccaacattt     1440

tcgacgccgg agtggccggg ttgcccgatg acgacgcggg tgagctgcca gcggccgtgg     1500

tagtcctcga acatgggaaa acaatgaccg aaaaggagat cgtggactac gtagcatcac     1560

aagtgacgac tgcgaagaaa ctgaggggag gggtagtctt tgtggacgag gtcccgaaag     1620

gcttgactgg gaagcttgac gctcgcaaaa tccgggaaat cctgattaag gcaaagaaag     1680

gcgggaaaat cgctgtctga taataggctg gagcctcggt ggccatgctt cttgcccctt     1740

gggcctcccc ccagcccctc ctccccttcc tgcacccgta cccccgtggt ctttgaataa     1800

agtctgagtg ggcggctcta ga                                              1822


<210>  4
<211>  1822
<212>  RNA
<213>  Homo sapiens

<400>  4
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gaagaugcga       60

agaacaucaa gaagggaccu gccccguuuu acccuuugga ggacgguaca gcaggagaac      120

agcuccacaa ggcgaugaaa cgcuacgccc ugguccccgg aacgauugcg uuuaccgaug      180

cacauauuga gguagacauc acauacgcag aauacuucga aaugucggug aggcuggcgg      240

aagcgaugaa gagauauggu cuuaacacua aucaccgcau cguggugugu ucggagaacu      300

cauugcaguu uuucaugccg guccuuggag cacuuuucau cggggucgca gucgcgccag      360

cgaacgacau cuacaaugag cgggaacucu ugaauagcau gggaaucucc cagccgacgg      420

ucguguuugu cuccaaaaag gggcugcaga aaauccucaa cgugcagaag aagcucccca      480

uuauucaaaa gaucaucauu auggauagca agacagauua ccaaggguuc cagucgaugu      540

auaccuuugu gacaucgcau uugccgccag gguuuaacga guaugacuuc guccccgagu      600

cauuugacag agauaaaacc aucgcgcuga uuaugaauuc cucggguagc accgguuugc      660

caaagggggu ggcguugccc caccgcacug cuugugugcg guucucgcac gcuagggauc      720

cuaucuuugg uaaucagauc auucccgaca cagcaauccu guccguggua ccuuuucauc      780

acgguuuugg cauguucacg acucucggcu auuugauuug cgguuucagg gucguacuua      840

uguaucgguu cgaggaagaa cuguuuuuga gauccuugca agauuacaag auccagucgg      900

cccuccuugu gccaacgcuu uucucauucu uugcgaaauc gacacuuauu gauaaguaug      960

accuuuccaa ucugcaugag auugccucag ggggagcgcc gcuuagcaag gaagucgggg     1020

aggcaguggc caagcgcuuc caccuucccg gaauucggca gggauacggg cucacggaga     1080

caacauccgc gauccuuauc acgcccgagg gugacgauaa gccgggagcc gucggaaaag     1140

ugguccccuu cuuugaagcc aaggucguag accucgacac gggaaaaacc cucggaguga     1200

accagagggg cgagcucugc gugagagggc cgaugaucau gucagguuac gugaauaacc     1260

cugaagcgac gaaugcgcug aucgacaagg augggugguu gcauucggga gacauugccu     1320

auugggauga ggaugagcac uucuuuaucg uagaucgacu uaagagcuug aucaaauaca     1380

aaggcuauca gguagcgccu gccgagcucg agucaauccu gcuccagcac cccaacauuu     1440

ucgacgccgg aguggccggg uugcccgaug acgacgcggg ugagcugcca gcggccgugg     1500

uaguccucga acaugggaaa acaaugaccg aaaaggagau cguggacuac guagcaucac     1560

aagugacgac ugcgaagaaa cugaggggag ggguagucuu uguggacgag gucccgaaag     1620

gcuugacugg gaagcuugac gcucgcaaaa uccgggaaau ccugauuaag gcaaagaaag     1680

gcgggaaaau cgcugucuga uaauaggcug gagccucggu ggccaugcuu cuugccccuu     1740

gggccucccc ccagccccuc cuccccuucc ugcacccgua cccccguggu cuuugaauaa     1800

agucugagug ggcggcucua ga                                              1822


<210>  5
<211>  751
<212>  DNA
<213>  Homo sapiens

<400>  5
gggaaataag agagaaaaga agagtaagaa gaaatataag agccaccatg ggagtgcacg       60

agtgtcccgc gtggttgtgg ttgctgctgt cgctcttgag cctcccactg ggactgcctg      120

tgctgggggc accacccaga ttgatctgcg actcacgggt acttgagagg taccttcttg      180

aagccaaaga agccgaaaac atcacaaccg gatgcgccga gcactgctcc ctcaatgaga      240

acattactgt accggataca aaggtcaatt tctatgcatg gaagagaatg gaagtaggac      300

agcaggccgt cgaagtgtgg caggggctcg cgcttttgtc ggaggcggtg ttgcggggtc      360

aggccctcct cgtcaactca tcacagccgt gggagcccct ccaacttcat gtcgataaag      420

cggtgtcggg gctccgcagc ttgacgacgt tgcttcgggc tctgggcgca caaaaggagg      480

ctatttcgcc gcctgacgcg gcctccgcgg cacccctccg aacgatcacc gcggacacgt      540

ttaggaagct ttttagagtg tacagcaatt tcctccgcgg aaagctgaaa ttgtatactg      600

gtgaagcgtg taggacaggg gatcgctgat aataggctgg agcctcggtg gccatgcttc      660

ttgccccttg ggcctccccc cagcccctcc tccccttcct gcacccgtac ccccgtggtc      720

tttgaataaa gtctgagtgg gcggctctag a                                     751


<210>  6
<211>  751
<212>  RNA
<213>  Homo sapiens

<400>  6
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug ggagugcacg       60

agugucccgc gugguugugg uugcugcugu cgcucuugag ccucccacug ggacugccug      120

ugcugggggc accacccaga uugaucugcg acucacgggu acuugagagg uaccuucuug      180

aagccaaaga agccgaaaac aucacaaccg gaugcgccga gcacugcucc cucaaugaga      240

acauuacugu accggauaca aaggucaauu ucuaugcaug gaagagaaug gaaguaggac      300

agcaggccgu cgaagugugg caggggcucg cgcuuuuguc ggaggcggug uugcgggguc      360

aggcccuccu cgucaacuca ucacagccgu gggagccccu ccaacuucau gucgauaaag      420

cggugucggg gcuccgcagc uugacgacgu ugcuucgggc ucugggcgca caaaaggagg      480

cuauuucgcc gccugacgcg gccuccgcgg caccccuccg aacgaucacc gcggacacgu      540

uuaggaagcu uuuuagagug uacagcaauu uccuccgcgg aaagcugaaa uuguauacug      600

gugaagcgug uaggacaggg gaucgcugau aauaggcugg agccucggug gccaugcuuc      660

uugccccuug ggccuccccc cagccccucc uccccuuccu gcacccguac ccccgugguc      720

uuugaauaaa gucugagugg gcggcucuag a                                     751


<210>  7
<211>  925
<212>  DNA
<213>  Homo sapiens

<400>  7
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggtatc caagggggag gaggacaaca      120

tggcgatcat caaggagttc atgcgattca aggtgcacat ggaaggttcg gtcaacggac      180

acgaatttga aatcgaagga gagggtgaag gaaggcccta tgaagggaca cagaccgcga      240

aactcaaggt cacgaaaggg ggaccacttc ctttcgcctg ggacattctt tcgccccagt      300

ttatgtacgg gtccaaagca tatgtgaagc atcccgccga tattcctgac tatctgaaac      360

tcagctttcc cgagggattc aagtgggagc gggtcatgaa ctttgaggac gggggtgtag      420

tcaccgtaac ccaagactca agcctccaag acggcgagtt catctacaag gtcaaactgc      480

gggggactaa ctttccgtcg gatgggccgg tgatgcagaa gaaaacgatg ggatgggaag      540

cgtcatcgga gaggatgtac ccagaagatg gtgcattgaa gggggagatc aagcagagac      600

tgaagttgaa agatggggga cattatgatg ccgaggtgaa aacgacatac aaagcgaaaa      660

agccggtgca gcttcccgga gcgtataatg tgaatatcaa gttggatatt acttcacaca      720

atgaggacta cacaattgtc gaacagtacg aacgcgctga gggtagacac tcgacgggag      780

gcatggacga gttgtacaaa tgataatagg ctggagcctc ggtggccatg cttcttgccc      840

cttgggcctc cccccagccc ctcctcccct tcctgcaccc gtacccccgt ggtctttgaa      900

taaagtctga gtgggcggct ctaga                                            925


<210>  8
<211>  730
<212>  DNA
<213>  Homo sapiens

<400>  8
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggtttt taccctcgaa gattttgtcg      120

gagattggag acagactgcc ggatacaacc ttgaccaagt cctcgagcaa ggcggtgtgt      180

cgtcactctt ccaaaacctg ggtgtgtccg tgactcccat ccagcgcatc gtcctgagcg      240

gcgaaaatgg gttgaagatc gacatccatg tgatcattcc atacgaggga ctgtccgggg      300

accagatggg tcagatcgaa aagattttca aagtggtgta cccggtcgac gatcatcact      360

tcaaggtgat cctgcactac ggaacgctgg tgatcgatgg ggtgaccccg aacatgattg      420

actatttcgg acggccttac gagggcatcg cagtgttcga cggaaagaag atcaccgtga      480

ccggcactct gtggaatgga aacaaaatca tcgacgaacg cctgatcaat ccggatggct      540

cgctgttgtt ccgggtgacc attaacggag tcactggatg gaggctctgc gagcgcatcc      600

ttgcgtgata ataggctgga gcctcggtgg ccatgcttct tgccccttgg gcctcccccc      660

agcccctcct ccccttcctg cacccgtacc cccgtggtct ttgaataaag tctgagtggg      720

cggctctaga                                                             730


<210>  9
<211>  796
<212>  DNA
<213>  Homo sapiens

<400>  9
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgggagt gcacgagtgt cccgcgtggt      120

tgtggttgct gctgtcgctc ttgagcctcc cactgggact gcctgtgctg ggggcaccac      180

ccagattgat ctgcgactca cgggtacttg agaggtacct tcttgaagcc aaagaagccg      240

aaaacatcac aaccggatgc gccgagcact gctccctcaa tgagaacatt actgtaccgg      300

atacaaaggt caatttctat gcatggaaga gaatggaagt aggacagcag gccgtcgaag      360

tgtggcaggg gctcgcgctt ttgtcggagg cggtgttgcg gggtcaggcc ctcctcgtca      420

actcatcaca gccgtgggag cccctccaac ttcatgtcga taaagcggtg tcggggctcc      480

gcagcttgac gacgttgctt cgggctctgg gcgcacaaaa ggaggctatt tcgccgcctg      540

acgcggcctc cgcggcaccc ctccgaacga tcaccgcgga cacgtttagg aagcttttta      600

gagtgtacag caatttcctc cgcggaaagc tgaaattgta tactggtgaa gcgtgtagga      660

caggggatcg ctgataatag gctggagcct cggtggccat gcttcttgcc ccttgggcct      720

ccccccagcc cctcctcccc ttcctgcacc cgtacccccg tggtctttga ataaagtctg      780

agtgggcggc tctaga                                                      796


<210>  10
<211>  793
<212>  DNA
<213>  Mus musculus

<400>  10
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatgggggt gcccgaacgt cccaccctgc      120

tgcttttact ctccttgcta ctgattcctc tgggcctccc agtcctctgt gctcccccac      180

gcctcatctg cgacagtcga gttctggaga ggtacatctt agaggccaag gaggcagaaa      240

atgtcacgat gggttgtgca gaaggtccca gactgagtga aaatattaca gtcccagata      300

ccaaagtcaa cttctatgct tggaaaagaa tggaggtgga agaacaggcc atagaagttt      360

ggcaaggcct gtccctgctc tcagaagcca tcctgcaggc ccaggccctg ctagccaatt      420

cctcccagcc accagagacc cttcagcttc atatagacaa agccatcagt ggtctacgta      480

gcctcacttc actgcttcgg gtactgggag ctcagaagga attgatgtcg cctccagata      540

ccaccccacc tgctccactc cgaacactca cagtggatac tttctgcaag ctcttccggg      600

tctacgccaa cttcctccgg gggaaactga agctgtacac gggagaggtc tgcaggagag      660

gggacaggtg ataataggct ggagcctcgg tggccatgct tcttgcccct tgggcctccc      720

cccagcccct cctccccttc ctgcacccgt acccccgtgg tctttgaata aagtctgagt      780

gggcggctct aga                                                         793


<210>  11
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' U-rich region

<400>  11
tttttctttt                                                              10


<210>  12
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' U-rich region

<400>  12
ttttgctttt t                                                            11


<210>  13
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' U-rich region

<400>  13
ttttgctttt                                                              10


<210>  14
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' A-rich region

<400>  14
aaaaagcaaa a                                                            11


