                         SEQUENCE LISTING

<110>  BUROVA, Elena
       MUJICA, Alexander O.
       LAI, Ka-Man Venus O.
       MURPHY, Andrew J.
 
<120>  NON-HUMAN ANIMALS HAVING A HUMANIZED PROGRAMMED CELL DEATH 1 GENE

<130>  31969 (10121US1)

<150>  62/086,518
<151>  2014-12-02

<150>  62/138,221
<151>  2015-03-25

<150>  62/014,181
<151>  2014-06-19

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1972
<212>  DNA
<213>  Mus musculus

<400>  1
tgagcagcgg ggaggaggaa gaggagactg ctactgaagg cgacactgcc aggggctctg       60

ggcatgtggg tccggcaggt accctggtca ttcacttggg ctgtgctgca gttgagctgg      120

caatcagggt ggcttctaga ggtccccaat gggccctgga ggtccctcac cttctaccca      180

gcctggctca cagtgtcaga gggagcaaat gccaccttca cctgcagctt gtccaactgg      240

tcggaggatc ttatgctgaa ctggaaccgc ctgagtccca gcaaccagac tgaaaaacag      300

gccgccttct gtaatggttt gagccaaccc gtccaggatg cccgcttcca gatcatacag      360

ctgcccaaca ggcatgactt ccacatgaac atccttgaca cacggcgcaa tgacagtggc      420

atctacctct gtggggccat ctccctgcac cccaaggcaa aaatcgagga gagccctgga      480

gcagagctcg tggtaacaga gagaatcctg gagacctcaa caagatatcc cagcccctcg      540

cccaaaccag aaggccggtt tcaaggcatg gtcattggta tcatgagtgc cctagtgggt      600

atccctgtat tgctgctgct ggcctgggcc ctagctgtct tctgctcaac aagtatgtca      660

gaggccagag gagctggaag caaggacgac actctgaagg aggagccttc agcagcacct      720

gtccctagtg tggcctatga ggagctggac ttccagggac gagagaagac accagagctc      780

cctaccgcct gtgtgcacac agaatatgcc accattgtct tcactgaagg gctgggtgcc      840

tcggccatgg gacgtagggg ctcagctgat ggcctgcagg gtcctcggcc tccaagacat      900

gaggatggac attgttcttg gcctctttga ccagattctt cagccattag catgctgcag      960

accctccaca gagagcaccg gtccgtccct cagtcaagag gagcatgcag gctacagttc     1020

agccaaggct cccagggtct gagctagctg gagtgacagc ccagcgcctg caccaattcc     1080

agcacatgca ctgttgagtg agagctcact tcaggtttac cacaagctgg gagcagcagg     1140

cttcccggtt tcctattgtc acaaggtgca gagctggggc ctaagcctat gtctcctgaa     1200

tcctactgtt gggcacttct agggacttga gacactatag ccaatggcct ctgtgggttc     1260

tgtgcctgga aatggagaga tctgagtaca gcctgctttg aatggccctg tgaggcaacc     1320

ccaaagcaag ggggtccagg tatactatgg gcccagcacc taaagccacc cttgggagat     1380

gatactcagg tgggaaattc gtagactggg ggactgaacc aatcccaaga tctggaaaag     1440

ttttgatgaa gacttgaaaa gctcctagct tcgggggtct gggaagcatg agcacttacc     1500

aggcaaaagc tccgtgagcg tatctgctgt ccttctgcat gcccaggtac ctcagttttt     1560

ttcaacagca aggaaactag ggcaataaag ggaaccagca gagctagagc cacccacaca     1620

tccagggggc acttgactct ccctactcct cctaggaacc aaaaggacaa agtccatgtt     1680

gacagcaggg aaggaaaggg ggatataacc ttgacgcaaa ccaacactgg ggtgttagaa     1740

tctcctcatt cactctgtcc tggagttggg ttctggctct ccttcacacc taggactctg     1800

aaatgagcaa gcacttcaga cagtcagggt agcaagagtc tagctgtctg gtgggcaccc     1860

aaaatgacca gggcttaagt ccctttcctt tggtttaagc ccgttataat taaatggtac     1920

caaaagcttt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1972


<210>  2
<211>  288
<212>  PRT
<213>  Mus musculus

<400>  2

Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         


Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             


Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 


Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 


Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     


Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         


Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  3
<211>  2115
<212>  DNA
<213>  Homo sapiens

<400>  3
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115


<210>  4
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  5
<211>  1972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Pdcd1

<400>  5
tgagcagcgg ggaggaggaa gaggagactg ctactgaagg cgacactgcc aggggctctg       60

ggcatgtggg tccggcaggt accctggtca ttcacttggg ctgtgctgca gttgagctgg      120

caatcagggt ggcttctaga ctccccagac aggccctgga acccccccac cttctcccca      180

gccctgctcg tggtgaccga aggggacaac gccaccttca cctgcagctt ctccaacaca      240

tcggagagct tcgtgctaaa ctggtaccgc atgagcccca gcaaccagac ggacaagctg      300

gccgccttcc ccgaggaccg cagccagccc ggccaggact gccgcttccg tgtcacacaa      360

ctgcccaacg ggcgtgactt ccacatgagc gtggtcaggg cccggcgcaa tgacagcggc      420

acctacctct gtggggccat ctccctggcc cccaaggcgc agatcaaaga gagcctgcgg      480

gcagagctca gggtgacaga gagaagggca gaagtgccca cagcccaccc cagcccctca      540

cccaggccag ccggccagtt ccaaaccctg gtcattggta tcatgagtgc cctagtgggt      600

atccctgtat tgctgctgct ggcctgggcc ctagctgtct tctgctcaac aagtatgtca      660

gaggccagag gagctggaag caaggacgac actctgaagg aggagccttc agcagcacct      720

gtccctagtg tggcctatga ggagctggac ttccagggac gagagaagac accagagctc      780

cctaccgcct gtgtgcacac agaatatgcc accattgtct tcactgaagg gctgggtgcc      840

tcggccatgg gacgtagggg ctcagctgat ggcctgcagg gtcctcggcc tccaagacat      900

gaggatggac attgttcttg gcctctttga ccagattctt cagccattag catgctgcag      960

accctccaca gagagcaccg gtccgtccct cagtcaagag gagcatgcag gctacagttc     1020

agccaaggct cccagggtct gagctagctg gagtgacagc ccagcgcctg caccaattcc     1080

agcacatgca ctgttgagtg agagctcact tcaggtttac cacaagctgg gagcagcagg     1140

cttcccggtt tcctattgtc acaaggtgca gagctggggc ctaagcctat gtctcctgaa     1200

tcctactgtt gggcacttct agggacttga gacactatag ccaatggcct ctgtgggttc     1260

tgtgcctgga aatggagaga tctgagtaca gcctgctttg aatggccctg tgaggcaacc     1320

ccaaagcaag ggggtccagg tatactatgg gcccagcacc taaagccacc cttgggagat     1380

gatactcagg tgggaaattc gtagactggg ggactgaacc aatcccaaga tctggaaaag     1440

ttttgatgaa gacttgaaaa gctcctagct tcgggggtct gggaagcatg agcacttacc     1500

aggcaaaagc tccgtgagcg tatctgctgt ccttctgcat gcccaggtac ctcagttttt     1560

ttcaacagca aggaaactag ggcaataaag ggaaccagca gagctagagc cacccacaca     1620

tccagggggc acttgactct ccctactcct cctaggaacc aaaaggacaa agtccatgtt     1680

gacagcaggg aaggaaaggg ggatataacc ttgacgcaaa ccaacactgg ggtgttagaa     1740

tctcctcatt cactctgtcc tggagttggg ttctggctct ccttcacacc taggactctg     1800

aaatgagcaa gcacttcaga cagtcagggt agcaagagtc tagctgtctg gtgggcaccc     1860

aaaatgacca gggcttaagt ccctttcctt tggtttaagc ccgttataat taaatggtac     1920

caaaagcttt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1972


<210>  6
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-1

<400>  6

Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         


Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             


Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 


Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 


Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     


Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         


Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 hTU Forward

<400>  7
cccagcagag acttctcaat gac                                               23


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 hTU Probe

<400>  8
tggcccttcc agagcccttg                                                   20


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 hTU Reverse

<400>  9
cggccacctg ctcacatc                                                     18


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 hTD Forward

<400>  10
ggcatctctg tcctctagct c                                                 21


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 hTD Probe

<400>  11
aagcacccca gcccctctag tctg                                              24


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 hTD Reverse

<400>  12
gggctgtggg cacttctg                                                     18


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 TU Forward

<400>  13
ccttcctcac agctctttgt tc                                                22


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 TU Probe

<400>  14
tctgcatttc agaggtcccc aatgg                                             25


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 TU Reverse

<400>  15
gagccaggct gggtagaag                                                    19


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 TD Forward

<400>  16
cggtgtccta gaactctatt ctttg                                             25


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: 7106 TD Probe

<400>  17
tcctggagac ctcaacaaga tatccca                                           27


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic Oligonucleotide: 7106 TD Reverse

<400>  18
tgaaaccggc cttctggtt                                                    19


<210>  19
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  19
tcaaaggaca gaatagtagc ctccagaccc taggttcagt tatgctgaag gaagagccct       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat atgcatggcc tccgcgccgg      120

gttttggcgc ctcccgcggg cgcccccctc ctcacg                                156


<210>  20
<211>  236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  20
ctggaataac ttcgtataat gtatgctata cgaagttatg ctagtaacta taacggtcct       60

aaggtagcga gctagcaaga ggctctgcag tggaggccag tgcccatccc cgggtggcag      120

aggccccagc agagacttct caatgacatt ccagctgggg tggcccttcc agagcccttg      180

ctgcccgagg gatgtgagca ggtggccggg gaggctttgt ggggccaccc agcccc          236


<210>  21
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  21
cccttccaga gagaagggca gaagtgccca cagcccaccc cagcccctca cccaggccag       60

ccggccagtt ccaaaccctg gtcattggta tcatgagtgc cctagtgggt atccctgtat      120

tgctgctgct ggcctgggcc ctagctgtct tctgctcaac                            160


<210>  22
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  22
tcaaaggaca gaatagtagc ctccagaccc taggttcagt tatgctgaag gaagagccct       60

ctcgagataa cttcgtataa tgtatgctat acgaagttat gctagtaact ataacggtcc      120

taaggtagcg agctagcaag aggctctgca gtggaggcca gtgcccatcc ccgggtggca      180

gaggccccag cagagacttc tcaatgacat tccagctggg gtggcccttc ca              232


<210>  23
<211>  883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: Human 883 bp DNA fragment

<400>  23
aagaggctct gcagtggagg ccagtgccca tccccgggtg gcagaggccc cagcagagac       60

ttctcaatga cattccagct ggggtggccc ttccagagcc cttgctgccc gagggatgtg      120

agcaggtggc cggggaggct ttgtggggcc acccagcccc ttcctcacct ctctccatct      180

ctcagactcc ccagacaggc cctggaaccc ccccaccttc tccccagccc tgctcgtggt      240

gaccgaaggg gacaacgcca ccttcacctg cagcttctcc aacacatcgg agagcttcgt      300

gctaaactgg taccgcatga gccccagcaa ccagacggac aagctggccg ccttccccga      360

ggaccgcagc cagcccggcc aggactgccg cttccgtgtc acacaactgc ccaacgggcg      420

tgacttccac atgagcgtgg tcagggcccg gcgcaatgac agcggcacct acctctgtgg      480

ggccatctcc ctggccccca aggcgcagat caaagagagc ctgcgggcag agctcagggt      540

gacaggtgcg gcctcggagg ccccggggca ggggtgagct gagccggtcc tggggtgggt      600

gtcccctcct gcacaggatc aggagctcca gggtcgtagg gcagggaccc cccagctcca      660

gtccagggct ctgtcctgca cctggggaat ggtgaccggc atctctgtcc tctagctctg      720

gaagcacccc agcccctcta gtctgccctc acccctgacc ctgaccctcc accctgaccc      780

cgtcctaacc cctgaccttt gtgcccttcc agagagaagg gcagaagtgc ccacagccca      840

ccccagcccc tcacccaggc cagccggcca gttccaaacc ctg                        883


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  24
gctctggctg gtcttcagta tg                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  25
ttgccgtatg gttggtttga ac                                                22


<210>  26
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  26
agcagctctg ccctcat                                                      17


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  27
acttccacat gagcgtgg                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  28
gggctgtggg cacttctg                                                     18


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  29
gcagatcaaa gagagcctgc                                                   20


