                         SEQUENCE LISTING

<110>  WEST VIRGINIA UNIVERSITY
 
<120>  PRODUCTION OF LYSERGIC ACID BY GENETIC MODIFICATION OF A FUNGUS

<130>  0074539-000051

<140>  PCT/US2015/035784
<141>  2015-06-15

<150>  US 62/012,658
<151>  2014-06-16

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aspergillus fumigatus easA


<220>
<221>  Unsure
<222>  (1)..(1131)

<400>  1
atgcgagaag aaccgtcctc tgctcagcta ttcaagccgc tcaaggtggg aagatgtcat       60

ctccaacata ggatgatcat ggcgccgaca actcgattcc gggccgatgg acagggggtc      120

ccgcttcctt ttgtacaaga gtattacggt cagcgtgcat cggttcctgg caccctcctc      180

atcaccgaag caacagacat cacccccaag gcgatgggtt acaaacatgt cccggggata      240

tggagtgagc cgcagcgcga ggcgtggaga gagattgttt ctagagtcca ttcgaaaaaa      300

tgctttattt tctgccagtt atgggcgacc ggccgcgccg cagatccgga cgtactcgcc      360

gacatgaagg acctgatctc tagtagcgcc gtgcctgtag aagagaaggg acctcttccc      420

cgagctctga ctgaggacga aatccagcag tgcatcgcag attttgcgca ggcggcccga      480

aacgccatca atgctgggtt cgatggggtg gagatccatg gtgccaatgg gtacctcatc      540

gaccagttca cacagaagtc ttgcaaccac cgccaggatc gatggggcgg aagcatcgag      600

aatcgagctc gttttgcggt cgaggtaaca cgggcggtta tcgaggccgt gggtgccgat      660

cgtgtcggcg tcaaactctc cccctacagt cagtatctgg ggatgggaac aatggacgag      720

cttgtgccac agtttgagta tctcattgcc cagatgcggc gattggatgt cgcatatctc      780

catcttgcca actcccgatg gcttgatgag gaaaagcccc atcctgaccc taatcatgag      840

gtgtttgtgc gtgtctgggg tcaatcctca cctatcctgc tggcaggcgg gtatgatgcg      900

gcatcggcag agaaggtgac ggagcagatg gcggcagcga cttacaccaa tgtggccatt      960

gcttttggga ggtactttat ctcgactcca gacctgccct ttcgggtcat ggctggcatc     1020

cagcttcaaa agtacgatcg tgcctctttc tatagcacgc tatcaagaga aggctacctt     1080

gattaccctt tcagcgctga atatatggca ttgcataatt tccccgtcta a              1131


<210>  2
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epichloe festucae var. lolii x Epichloe typhina isolate Lp1 easA


<220>
<221>  Unsure
<222>  (1)..(1143)

<400>  2
atgtcaactt caaatctttt cacgccgctc caatttggaa aatgtctcct ccagcacaag       60

ctagtcctct caccgatgac tcgttttcgt gcggataatg aaggcgtccc gcttccctat      120

gtcaagactt actactgtca acgagcatct ctccctggca ccctgcttct taccgaagct      180

actgccatct ctcgccgagc cagagggttt cccaatgtcc ccgggatttg gagtcaggag      240

caaattgcag gctggaaaga ggtagttgat gctgtgcatg cgaaggggtc ttatatctgg      300

ctgcagcttt gggcgactgg acgagcagcc gaggttggtg ttctgaaagc gaatggattt      360

gatctcgtat ccagcagtgc cgttccagtc tcccccggtg agcccacacc ccgggcgctc      420

agcgacgatg agatcaactc atacatcggt gatttcgttc aagcagccaa aaatgcagtc      480

ctagaagcag gatttgacgg agtcgaactc cacggtgcca atggatttct catcgatcag      540

tttctccaat ctccttgcaa ccaacgtacc gatcaatggg gcggttgcat tgagaatcgc      600

tcacggttcg gtcttgaaat cacccggcga gtcatcgacg ctgtcggtaa agaccatgtg      660

ggcatgaagc tttccacttg gagtaccttc cagggaatgg gcaccatgga cgacctcata      720

cctcagttcg agcatttcat catgcgcctt cgtgagatag gcattgccta tctacacctt      780

gctaactctc gctgggtaga ggaggaagac cccaccatca gaacacatcc agatattcat      840

aatgagactt ttgtgcgcat gtgggggaaa gagaagcctg tccttttggc tggtggctac      900

ggcccggagt ccgccaagct tgtggtagat gaaacatact ctgaccacaa gaacatcggt      960

gtcgtttttg gacgacacta tatatccaac ccagatcttc cattccggct gaaaatggga     1020

ctccctcttc aaaagtacaa tcgggaaact ttctacattc cgttctctga cgagggatac     1080

ttggattacc cctatagtga ggaatacata acagagaaca agaagcaggc agttctagca     1140

taa                                                                   1143


<210>  3
<211>  2089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epichloe festucae var. lolii x Epichloe typhina isolate Lp1 cloA


<220>
<221>  Unsure
<222>  (1)..(2089)

<400>  3
atgatattac catggttatc ccagcttcaa tcggtctcac tagggacgat tttcctcacg       60

ctattcctcg ttatattgac tcctttggtt ttcacaagcg tttaccgtct gtattttcat      120

cctcttcgca aaattcctgg accacgaacc gggggtttga caagtttcta tgggttctat      180

tggaactgga tacgagatga aggatactct aagctcttca atcccctgca taaacaatat      240

agtaaggttt atttcccgaa taaatacccc ttgtgaatgc taagatgcat caagattccc      300

atatcatacg tatcggccca aaccatgttc acatcaacca accgcaagct tttgatgagt      360

tcgtacaaga ctcctctaca cttctaaact gtggagggct cacacaaata aaaattagga      420

tattcaaagt tggaacaaca tggcgcaaag acagctcatt ttacaagtat tttaacggct      480

tggacgccat gattgagccg acgcaatatc gcacctaccg aactcacttg gcccctttat      540

acgcacaacg ctccattgat ggcttaacac caaagctcca tgacgacctc gtggtaactg      600

ccgaaaggat ggccaagagc atcgaaaatg gtgaacctgt gaacatggtg aagatattgc      660

ggacattgag tgtaagtata tagtggttgt tcaaaaacca ctgtatttcg actaacggcc      720

aacgggaata gacctcaatg atgctttata ctttgtattc gcaggacatc ccgctctctc      780

aatatgatgg gtatcacccg tttctagaag cttttgagct gctcatgacc caaagttggc      840

taagtgagtc tgtatcacat ttcaggtcac agtttgcttt attgtataca ggaacgctga      900

taatttgttt ctgtacaaag tgatcaatta tcccatgatg ggtatgatcc ttggcctaat      960

tcccggcacg agctttgcga aattcaatgc cgctttcgga accttcttga aggttagtta     1020

acttgcggag taacaaggga caaagcacac aaattgctaa aagaatgtta atttacagta     1080

ctgtaaagag tggaacgacg aggatgaacg cattcaaaag cttgaaactg ctgaatcact     1140

gcgggactcc cacatgaaac gataccttgc cattgaccca aataacgaga tcaaaaagaa     1200

ggtcgtgccg catcccctgg aggatatatt taactttatc gcaggcggta gtgacactac     1260

ttcatataca gctgcatgtg cattcttcca tgttctctcg tcgtctgagg tgcactctaa     1320

gctcgtggcg gagctcgatc aagcttcttc agtgatcagg gatacctttg attacaataa     1380

gattcaaaac ttgccatatc tggtgtgtat acgattaaga gtttacctat catcattttt     1440

cccggaccct cttctgaaag taggctctaa ccatggatgt tgcagaatgc cgtgatcaag     1500

gagacgcttc gtatctcttg tccggtacca gggtgtcttc cccgagtcgt ccctgagggg     1560

ggaatgaatc tgggttcagt aaatcttcca gccggtgtaa gctccattta tacaaccttg     1620

tataagacta gtgacttgct aacgttgtga tatgcgaaca gacagtggtg tcaatctccc     1680

agctagccat ccactttaat gagacgattt tctcgtcacc tgacaagttc atccccgaaa     1740

gatggcttgg ggacgataga aaatcgattg agaagtggaa tatcgctttt agcagaggac     1800

ctcgacagtg cattgggaca acgtaagtct tccccccccc ccgatccggt gatagtatca     1860

aaataccacc attctctgct attgtagatg aatgaatgct gagttttaac gttttttgtt     1920

ccatagtctc gcttatatgg aactacgctg cgtcctcgct tatttcttct cccgctttga     1980

atttaagtta acgggtagct gtggagataa gttgcgctgg gttgatcgat ttgtctcagt     2040

caacttggac gatgtcgagg tcactatcgt gaaggaccga tgggcgtaa                 2089


<210>  4
<211>  4917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  easA & cloA from E. festucae var lolii x E. typhina isolate Lp1 
       in A. fumigatus


<220>
<221>  Unsure
<222>  (1)..(4917)

<400>  4
cgtatcaccg agacaaagag gcgcatcatt cactatcaat tattttcaga gatatctaaa       60

tgaaacaaaa tgactacagt attgtataat gatcacggag caccaaagac taagaagaca      120

atgataaaga taacttaatg aacgaaatac aaaagccata ccacactagt gtacctattc      180

ggtataagat ttaactctta gaggaatcat ttataaggct aatccaaaag aatgcaaaag      240

cattgcctgg actgcgataa tgatttatgc tagaactgcc tgcttcttgt tctctgttat      300

gtattcctca ctataggggt aatccaagta tccctcgtca gagaacggaa tgtagaaagt      360

ttcccgattg tacttttgaa gagggagtcc cattttcagc cggaatggaa gatctgggtt      420

ggatatatag tgtcgtccaa aaacgacacc gatgttcttg tggtcagagt atgtttcatc      480

taccacaagc ttggcggact ccgggccgta gccaccagcc aaaaggacag gcttctcttt      540

cccccacatg cgcacaaaag tctcattatg aatatctgga tgtgttctga tggtggggtc      600

ttcctcctct acccagcgag agttagcaag gtgtagatag gcaatgccta tctcacgaag      660

gcgcatgatg aaatgctcga actgaggtat gaggtcgtcc atggtgccca ttccctggaa      720

ggtactccaa gtggaaagct tcatgcccac atggtcttta ccgacagcgt cgatgactcg      780

ccgggtgatt tcaagaccga accgtgagcg attctcaatg caaccgcccc attgatcggt      840

acgttggttg caaggagatt ggagaaactg atcgatgaga aatccattgg caccgtggag      900

ttcgactccg tcaaatcctg cttctaggac tgcatttttg gctgcttgaa cgaaatcacc      960

gatgtatgag ttgatctcat cgtcgctgag cgcccggggt gtgggctcac cgggggagac     1020

tggaacggca ctgctggata cgagatcaaa tccattcgct ttcagaacac caacctcggc     1080

tgctcgtcca gtcgcccaaa gctgcagcca gatataagac cccttcgcat gcacagcatc     1140

aactacctct ttccagcctg caatttgctc ctgactccaa atcccgggga cattgggaaa     1200

ccctctggct cggcgagaga tggcagtagc ttcggtaaga agcagggtgc cagggagaga     1260

tgctcgttga cagtagtaag tcttgacata gggaagcggg acgccttcat tatccgcacg     1320

aaaacgagtc atcggtgaga ggactagctt gtgctggagg agacattttc caaattggag     1380

cggcgtgaaa agatttgaag ttgacattgc ttctaatcca ccaagtactt ggaacacggt     1440

gaatgtcgaa gctcagtctg accagtggag gtatcgacgc gaacttttca ggtcatggaa     1500

gtgtggagta tggtctacag gcttggagga ctttgtattg attctggcat cgataactga     1560

gcagacaaga cgccattcgg gcacaatttc tttctgctgg acaattctca tacagccatg     1620

tcgtccccct tgccgagcca acgccactat ttgtttatgt gtctattatt cgatattcac     1680

ggggaaaggt gagctgactt gtacgtactc tgtctactcc aatgccctca cctttcttca     1740

gctgcagagc cgtggagcgg aactccttgc ttccccgttt acatacttgg gaattgaaat     1800

caggacccat atctccatga cgagtctttt atcatgcaca tgggaaatgg cggtcagtta     1860

aaacatgatc aatactactg ttacgccttt actccaatgc accgatagct aataagaaga     1920

gctcctccac cctcccacaa agaggcaagg gagagccaga agagactgag ggtggtgggc     1980

gaaaacagct ccaagcgtat atgtgctact gtgcccaaga cttcaccgta ctttctcaat     2040

gtgtgaataa tgaggactag acgagacact cttaataaga gatcatctac cagaaagggc     2100

gtacgttact accaaactct gtgtgattaa atgtacacac attctttcaa caaacaaatt     2160

tgatccatct tctatagagt aggcactccg caccatgata ttaccatggt tatcccagct     2220

tcaatcggtc tcactaggga cgattttcct cacgctattc ctcgttatat tgactccttt     2280

ggttttcaca agcgtttacc gtctgtattt tcatcctctt cgcaaaattc ctggaccacg     2340

aaccgggggt ttgacaagtt tctatgggtt ctattggaac tggatacgag atgaaggata     2400

ctctaagctc ttcaatcccc tgcataaaca atatagtaag gtttatttcc cgaataaata     2460

ccccttgtga atgctaagat gcatcaagat tcccatatca tacgtatcgg cccaaaccat     2520

gttcacatca accaaccgca agcttttgat gagttcgtac aagactcctc tacacttcta     2580

aactgtggag ggctcacaca aataaaaatt aggatattca aagttggaac aacatggcgc     2640

aaagacagct cattttacaa gtattttaac ggcttggacg ccatgattga gccgacgcaa     2700

tatcgcacct accgaactca cttggcccct ttatacgcac aacgctccat tgatggctta     2760

acaccaaagc tccatgacga cctcgtggta actgccgaaa ggatggccaa gagcatcgaa     2820

aatggtgaac ctgtgaacat ggtgaagata ttgcggacat tgagtgtaag tatatagtgg     2880

ttgttcaaaa accactgtat ttcgactaac ggccaacggg aatagacctc aatgatgctt     2940

tatactttgt attcgcagga catcccgctc tctcaatatg atgggtatca cccgtttcta     3000

gaagcttttg agctgctcat gacccaaagt tggctaagtg agtctgtatc acatttcagg     3060

tcacagtttg ctttattgta tacaggaacg ctgataattt gtttctgtac aaagtgatca     3120

attatcccat gatgggtatg atccttggcc taattcccgg cacgagcttt gcgaaattca     3180

atgccgcttt cggaaccttc ttgaaggtta gttaacttgc ggagtaacaa gggacaaagc     3240

acacaaattg ctaaaagaat gttaatttac agtactgtaa agagtggaac gacgaggatg     3300

aacgcattca aaagcttgaa actgctgaat cactgcggga ctcccacatg aaacgatacc     3360

ttgccattga cccaaataac gagatcaaaa agaaggtcgt gccgcatccc ctggaggata     3420

tatttaactt tatcgcaggc ggtagtgaca ctacttcata tacagctgca tgtgcattct     3480

tccatgttct ctcgtcgtct gaggtgcact ctaagctcgt ggcggagctc gatcaagctt     3540

cttcagtgat cagggatacc tttgattaca ataagattca aaacttgcca tatctggtgt     3600

gtatacgatt aagagtttac ctatcatcat ttttcccgga ccctcttctg aaagtaggct     3660

ctaaccatgg atgttgcaga atgccgtgat caaggagacg cttcgtatct cttgtccggt     3720

accagggtgt cttccccgag tcgtccctga ggggggaatg aatctgggtt cagtaaatct     3780

tccagccggt gtaagctcca tttatacaac cttgtataag actagtgact tgctaacgtt     3840

gtgatatgcg aacagacagt ggtgtcaatc tcccagctag ccatccactt taatgagacg     3900

attttctcgt cacctgacaa gttcatcccc gaaagatggc ttggggacga tagaaaatcg     3960

attgagaagt ggaatatcgc ttttagcaga ggacctcgac agtgcattgg gacaacgtaa     4020

gtcttccccc ccccccgatc cggtgatagt atcaaaatac caccattctc tgctattgta     4080

gatgaatgaa tgctgagttt taacgttttt tgttccatag tctcgcttat atggaactac     4140

gctgcgtcct cgcttatttc ttctcccgct ttgaatttaa gttaacgggt agctgtggag     4200

ataagttgcg ctgggttgat cgatttgtct cagtcaactt ggacgatgtc gaggtcacta     4260

tcgtgaagga ccgatgggcg taagctgaaa gcgtccaaaa gtgcccggga ggcgtaggca     4320

cggccagagg gatgtatctt gacttggaga aaattaaggg cgggaagcaa gttaaactag     4380

gatctttcca tagtactatt taatgagcta accctatgaa gtgtgagggg acaagggtat     4440

taacgagttc aaatgccgct tacatatagc gatttttcac gagagacaga gattcctaaa     4500

tgccttagtt atattaagta actaaaaact gtaacttaag cctcgctagt aattgcacaa     4560

tatttataaa gtgagacatt tatcaaatat aaaagccaca tcgttctttt acgtggagca     4620

cattttagga gacataggga aaggtataag agggaacact gttacagtat tctcagactt     4680

tataataata acagtcaatg ttagagaaaa tatatggttc tttgagattt gttaacacag     4740

agccattaag acgttgttta ggcaatgtct taatagtggt gagttaccgc gtagtaatgt     4800

gcatgtattt taattagcca tagcaggcat acgtgccttt agttagttac ttatgcttat     4860

tgcttaccta aatacacgcc atacctaacg cttatcgctt gttgccctta gcgtgtt        4917


<210>  5
<211>  5037
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recipient strain Aspergillus fumigatus easA knockout


<220>
<221>  Unsure
<222>  (1)..(5037)

<400>  5
atgcgagaag aaccgtcctc tgctcagcta ttcaagccgc tcaaggtggg aagatgtcat       60

ctccaacata ggatgatcat ggcgccgaca actcgattcc gggccgatgg acagggggtc      120

ccgcttcctt ttgtacaaga gtattacggt cagcgtgcat cggttcctgg caccctcctc      180

atcaccgaag caacagacat cacccccaag gcgatgggtt acaaacatgt cccggggata      240

tggagtgagc cgcagcgcga ggcgtggaga gagattgttt ctagagtcca ttcgaaaaaa      300

tgctttattt tctgccagtt atgggcgacc ggccgcgccg cagatccgga cgtactcgcc      360

gacatgaagg acctgatctc tagtagcgcc gtgcctgtag aagagaaggg acctcttccc      420

cgagctctga ctgaggacga aatccagcag tgcatcgcag attttgcgca ggcggcccga      480

aacgccatca atgctgggtt cgatggggtg gagatccatg gtgccaatgg gtacctcatc      540

gaccagttca cacagaagtc ttgcaaccac cgccaggatc gatggggcgg aagcatcgag      600

aatcgagctc gttttgcggt cgaggtaaca cgggcggtta tcgaggccgt gggtgccgat      660

cgtgtcggcg tcaaactctc cccctacagt cagtatctgg ggatgggaac aatggacgag      720

cttgtgccac agtttgagta tctcattgcc cagatgcggc gattggatgt cgcatatagc      780

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg      840

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca      900

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg      960

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagcttggta     1020

ccgagctcgg atccactagt aacggccgcc agtgtgctgg aattcggctt aagccgaatt     1080

ctgcagatat ccatcacact ggcggccgct cgagcatgca tctagagggc ccaattcgcc     1140

ctatagtgag tcgtattaca attcactggc cgtcgtttta caacgtcgtg actgggaaaa     1200

ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa     1260

tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg     1320

ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac     1380

cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc     1440

cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt     1500

tagagcttta cggcacctcg accgcaaaaa acttgatttg ggtgatggtt cacgtagtgg     1560

gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag     1620

tggactcttg ttccaaactg gaacaacact caaccctatc gcggtctatt cttttgattt     1680

ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaattca     1740

gggcgcaagg gctgctaaag gaaccggaac acgtagaaag ccagtccgca gaaacggtgc     1800

tgaccccgga tgaatgtcag ctactgggct atctggacaa gggaaaacgc aagcgcaaag     1860

agaaagcagg tagcttgcag tgggcttaca tggcgatagc tagactgggc ggttttatgg     1920

acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg gaagccctgc     1980

aaagtaaact ggatggcttt cttgccgcca aggatctgat ggcgcagggg atcaagatct     2040

gatcaagaga caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt     2100

tctccggccg cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc     2160

tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag     2220

accgacctgt ccggtgccct gaatgaactg caggacgagg cagcgcggct atcgtggctg     2280

gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac     2340

tggctgctat tgggcgaagt gccggggcag gatctcctgt catctcgcct tgctcctgcc     2400

gagaaagtat ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc     2460

tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc     2520

ggtcttgtcg atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg     2580

ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc tcgtcgtgat ccatggcgat     2640

gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcaa cgactgtggc     2700

cggctgggtg tggcggaccg ctatcaggac atagcgttgg atacccgtga tattgctgaa     2760

gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat     2820

tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgaattga aaaaggaaga     2880

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     2940

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     3000

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     3060

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtcat acactattat     3120

cccgtattga cgccgggcaa gagcaactcg gtcgccgggc gcggtattct cagaatgact     3180

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     3240

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     3300

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     3360

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagagt gacaccacga     3420

tgcctgtagc aatgccaaca acgttgcgca aactattaac tggcgaacta cttactctag     3480

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     3540

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     3600

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     3660

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     3720

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     3780

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     3840

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     3900

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     3960

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     4020

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     4080

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     4140

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     4200

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     4260

tggagcgaac gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca     4320

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     4380

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     4440

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     4500

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     4560

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     4620

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     4680

aagctccatc ttgccaactc ccgatggctt gatgaggaaa agccccatcc tgaccctaat     4740

catgaggtgt ttgtgcgtgt ctggggtcaa tcctcaccta tcctgctggc aggcgggtat     4800

gatgcggcat cggcagagaa ggtgacggag cagatggcgg cagcgactta caccaatgtg     4860

gccattgctt ttgggaggta ctttatctcg actccagacc tgccctttcg ggtcatggct     4920

ggcatccagc ttcaaaagta cgatcgtgcc tctttctata gcacgctatc aagagaaggc     4980

taccttgatt accctttcag cgctgaatat atggcattgc ataatttccc cgtctaa        5037


<210>  6
<211>  6662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  disarmed strain of Aspergillus fumigatus


<220>
<221>  Unsure
<222>  (1)..(6662)

<400>  6
atggaggatc tccatcgcct ctatctcttt ggagatcaga caatcagctg tgacgaaggc       60

ctccgcaacc tcttgcaggc gaagaaccat actatcgtcg cctcgttcat cgaaagatgc      120

ttccatgcac tgcgtcagga aatcaccagg ctgccgcctt ctcagcgcac gctcttcccg      180

cggtttacca gcatcgccga cttgcttgct cagcatcgtg agtcagggac aaaccctgcg      240

ctggggagcg cgctgacctg tatctatcaa ctggggtgtt tcatcgagta agtcgccttg      300

caaggtattc tggactgtgg ctgatcctgg atagttacca cggtgatcgt ggacatccat      360

atccgtcctc ggatgacggc cttctgggtt catgtacggg tatgttgagt tgcaccgcag      420

tcagctcgtg caagaatgtc ggagaactac tgccgctggc agtcgagatt gtcagattga      480

ctatccacct cgggctctgt gtcatgagag tccgagagat ggtggactcg acggagtcat      540

cctccggcag ctggtcaatc ctcgtctcgg agatcaacga ggcagatgcc accagcctga      600

ttggcaattt tgtcaagaag cgagtaagta cagtgtacga ccattggaag aagaatattg      660

acaataccag ggaattcccc cctcgtcgca accgtacatc agcgcggttg gatcgaaagg      720

tctcaccatc agtgcaccac ccgaaattct cgacaacttt atcgaagaag gtcttccgaa      780

ggagtacaaa cacttcaagg ctcctggagt cagtggtccg taccacgcgc cccatctgta      840

caatgaccga gaaattcgca atatcctcag cttctgctcc gaggacgtga ttctgcgcca      900

cacaccacgg gttccactgg tctcgagcaa cacagggaag ctggtccagg taaagagcat      960

gcgtgatctg ctaaaggtgg ctctggagga aatcctcttg cgcaagatct gctgggacaa     1020

agtcaccgag tcatgccttt ccatcgttca ggctaccaac gacaagccct ggaggattct     1080

ccctatcgcc agcaacgcca cgcaaggctt ggttactgca ctccagcgta tgggaaactg     1140

ccagatcgag gtagacaccg gggtcggcgc tcctcaaatg gacccggccg ctcccaatgc     1200

aacgggcaat gcttcacggt ctaagatcgc catcatcgga atgtctgggc ggttccctga     1260

ggcagatggt atcgaggcct tttgggactt gttgtataaa ggtctggatg ttcacaaaaa     1320

ggtcccacct gagcgatggg atgtggacgc gcacgtggac ttgaccggca caaagagaaa     1380

caccagcaag gtcccatacg gttgctggat caacgagccc ggcctgttcg atgcccgttt     1440

cttcaacatg tctcctcggg aagcactcca ggcagaccct gcgcagcgac tggcgctgct     1500

gtcggcttac gaggccctgg aaatggcagg cttcgttccg aacagcagtc catcgactca     1560

gagagaccgc gtcggcatct tcatgggtat gaccagcgac gactaccgtg agatcaacag     1620

cggtcaggat atcgacacat acttcattcc tggagggaac cgagcattca cgcctggtcg     1680

tatcaactac tacttcaagt tcagtgggcc tagtgtcagt gtcgacaccg cctgctcgtc     1740

cagtcttgct gccatccact tggcctgcaa cgccatctgg aggaatgact gcgataccgc     1800

catcagtggt ggtgtaaacc tccttactaa cccggacaac catgccggtc tggatcgcgg     1860

ccactttctg tctcggacag gaaactgcaa caccttcgac gacggcgcgg atggctactg     1920

ccgggcggac ggggtgggca cgatcgtcct gaagcgcctg gaggatgctg aggctgacaa     1980

cgatcccatt ctgggagtca ttaacgcggc ctacaccaac cactcggccg aagccgtctc     2040

cattacccgc cctcacgtcg gcgcgcaggc gttcatcttc aacaagctcc tcaacgacac     2100

caacaccaac ccacacgaga ttggctacgt ggaaatgcac ggaacaggta ctcaggcggg     2160

cgacgccgtt gagatgcagt ccgtcctcga cgtcttcgca cccgactacc gccgcgggcc     2220

ggccaattcc ctttatctgg gttccgccaa atcgaacatc ggccacgggg aatcagcttc     2280

cggagtgaca tccttggtca aggtcctgtt gatgttgaag cagaacatga tcccgcccca     2340

ctgcggaatc aaaacaaaga tcaatcacaa cttccccacg gatctggccc agcgcaatgt     2400

ccatattgcc ttcaagccaa ccccctggaa cagaccggtc tcgggcaagc ggaagatgtt     2460

catcaacaac ttctctgctg cgggcggcaa caccgctctc ctgatggaag atgcccccct     2520

gcgtgagatc acagggcagg atccccggaa tgtgcatgtg gtgtctgtga cggcacggtc     2580

gcagactgcg ctgaagcgta acatcaacgc gttgatcaag tacatcaaca cgcatgcgcc     2640

ctcgtcgccg gcgaatgagc gacggttcct ggccagtctg gcttatacta ctaccgcgcg     2700

tcgcatgcat caccccttca gggtcaccgc agtggggtcg agcgtgaagg atatccggga     2760

ggtcctgcgt caacgtgccg atcaggatgt caccaccccc gtccctgcga cagcccccaa     2820

gactgggttc gtcttcaccg gtcagggagc tcagtacaca gggatgggca agcaattgta     2880

cgaggactgt gccacattca gaagcacgat tcaccgactc gattgcattg ctcaaagcca     2940

agggttcccc tccattctac cgttgattga cggtagtatg cctgtggaag aactgagccc     3000

tgtcgtgacc cagctaggaa ccacatgcct gcagatggct ctggtcgact actggaaggg     3060

tcttggtgtc actcctgcgt ttgttctggg acatagtctg ggagactacg cagcgttgaa     3120

cagtgcgggc gtcttgtcca ccagcgatac gatttacctc tgtggccgtc gcgcgcagct     3180

tctcacgcag cagtgtcaga tggggaccca cgccatgctt gccgtcaagg ctgccgtctc     3240

cgagattcaa catctgctcg atccagacgt ccacgccgtc gcctgcatca atggaccaac     3300

cgaaacggtc atcagcgggc tcagcggtcg aatcgatgaa ttggcacagc agtgctccag     3360

ccaaaatctc aagtccacca agctcaaagt gccgttcgcg ttccactcgg cccaagtgga     3420

cccgattctc gagtcgttcg aagagagtgc tcagggggtc atcttccacg aacctgccgt     3480

cccgttcgtc tctgctctga acggagaggt aatcacggag tcgaactaca gcgtgctggg     3540

ccccacgtat atggtgaagc attgtcggga agccgtcaat ttccttggcg ctcttgaggc     3600

gacccggcac gccaagttga tggatgacgc cacactctgg gtcgaagtgg gatcccatcc     3660

catttgctcg ggtatgatca agtccacctt tggcccgcag gcgactaccg ttccttcgct     3720

ccgccgcgac gacgatccat ggaaaatcct ctccaacagc ctctccacgc tgcaccttgc     3780

aggcgtcgag ctcaactgga aggaattcca ccaggacttc agctcggctc acgaggttct     3840

cgagttaccc cggtacggct gggatctgaa gaattactgg atcccctaca cgaacaactt     3900

ctgccttacc aaggggggtc ccgttaccgc ggaggtatcg gcgcccaagt ctaccttcct     3960

cacgaccgcg gcgcaaaaga ttgtggaatg ccgggaggac ggaaacacgg cgacattggt     4020

agttgagaat aatatcgcag agccagaact caaccgtgtt atccaaggtc acaaggtcaa     4080

tggagtggct cttacgccat cggtgagttt gaactgcact caccactctg gaatagaaag     4140

ctaatcccta tacgtagtct ctctacgctg atattgcgca aacgcttgtc gaccacttga     4200

tcacaaaata caaaccagag taccagggcc taggtctgga cgtgtgcgac atgactgtgc     4260

ccaagcctct catagccaag tccggagatc aattcttcag agtctcggcg gtgatgagct     4320

gggccgagca gaaggcgagc gtgcaagtct ggtctgtgaa cggagacggc aagaaaatgg     4380

ccgagcacgc ccattgcact gtcaagctct tcaactgcgc cgagcgcgag acggagtgga     4440

agagaaactc ctacctcatc aaacgaagtg tctctctcct gcaggacaag gcgcagaccg     4500

gcgaggctca ccgcatgcag cgaggaatgg tgtacaagct gtttgctgct ctggtggact     4560

atgacgaaaa cttcaaggcc atccaggaag tcatcctgga cagcaatgag catgaagcca     4620

cggcgcgagt caagttccaa gcccctccgg gcaacttcca ccggaacccc ttctggatcg     4680

atagtttcgg gcatctgtct gggttcatca tgaatgcgag cgatgcgacc gactccaaga     4740

accaggtatt cgtcaaccac ggatgggatt ccatgcgctg cctgaagaag ttctccggcg     4800

acgctacata ccagacatat gtgaagatgc agccgtggaa ggactccatc tgggcgggtg     4860

acgtctatgt ctttgaaggg gatgacatta tcgctgtgta cgggggggtc aaggtatgtc     4920

tctaaattac aattgaaaag aaaaaaaaaa aaaaaaaata attttactaa cggcggccta     4980

tacagttcca agcgctggct cgaaagatct tggataccgt tctccctcca atcggaggat     5040

ccaagaccgt cggtgcgccg gcgccggcgc cagcaaggcc cattggggag aagaaagctc     5100

ctcccccgat caaggtcact ggtcctccca agcccaaccc cagcaacgca cgtgctgcat     5160

caccggtggt tgcacgggca ttggagatcc tggctgcgga ggtcggtctg tccgaggctg     5220

aaatgaccga cagtctcaac ttcgccgact acggggtcga ctcgctgctt tccttgacgg     5280

tgaccggcag gtatcgtgaa gaactgaacc ttgatctgga atcgtccgtg ttcatggatt     5340

acccgaccat caaggatttc aaggcctacc tggccgagaa gggcttctgc gacagcagca     5400

gtcccgagcc gtccagcgag cccgagtcca agttctcgtt caacagcgac gcatcatccg     5460

aagcttccag cggacttacc actcctggaa ttacatctcc tgtgaagcat gaggcgccca     5520

agggcggaca gaacaaagtc tggaaaagca tctgcagtat catcgccgag gaaatcgggg     5580

tgtcggtcgg agacattgac ccgagcgaca acttgccaga gatgggcatg gactcgctgc     5640

tgtccctgac cgtgctcggt cggatccgag agacacttgg catggatctg ccggcagagt     5700

tcttcctcga gaacccgacc ctcgatgcgg tgcaagctgc gctggatctg aagcccaaga     5760

tggtccccgc cgcgacgccg gtctccgaac ccatccggct cctcgagaca atcgacaaca     5820

cgaagcccaa gacgtctcga catcctccgg cgacctcgat tcttctccag ggcaaccccc     5880

acaccgccac caagaagctc ttcatgttcc cggacggctc gggctccgcc tcctcctacg     5940

cgacgattcc ggccctctcc ccggatgtct gtgtgtatgg tctcaattgc ccttacatga     6000

agacgcctca gaacctcacg tgcagtcttg acgagctgac cgagccctat ctggcggaga     6060

tccgccgacg tcagcccaag ggaccgtaca gctttggtgg ttggtcggcg ggtggcatct     6120

gcgcctttga cgccgcgcgc cagctgatcc tcgaggaagg ggaggaggtg gagcggttgc     6180

tgctgctcga ctcgcccttc cccatcggtc tggagaagct gcctcctcgt ctgtacaagt     6240

tcttcaactc gattgggctc tttggcgacg ggaagcgggc gcctcccgac tggctcctcc     6300

cccacttcct cgccttcatc gactcgctcg acgcctacaa agcggttccg ctgccgttca     6360

acgacagcaa atgggctaag aagatgccca agacctacct gatctgggcc aaggacggag     6420

tctgcggcaa gccgggcgat ccccggccgg agcctgcaga ggatggatcc gaggaccccc     6480

gcgaaatgca gtggctgctc aacgaccgaa cggatctggg accaaacaaa tgggatactt     6540

tggtgggccc gcaaaacatt ggcggaatcc atgtgatgga ggacgcgaat catttcacca     6600

tgacgacggg acagaaggcg aaggagttgt cgcaattcat ggccacggcc atgagttcct     6660

ag                                                                    6662


<210>  7
<211>  4539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutate alb1 of Aspergillus fumigatus


<220>
<221>  Unsure
<222>  (1)..(4539)

<400>  7
gatagcggcc gccttgcagg cgaagaacca tactatcgtc gcctcgttca tcgaaagatg       60

cttccatgca ctgcgtcagg aaatcaccag gctgccgcct tctcagcgca cgctcttccc      120

gcggtttacc agcatcgccg acttgcttgc tcagcatcgt gagtcaggga caaaccctgc      180

gctggggagc gcgctgacct gtatctatca actggggtgt ttcatcgagt aagtcgcctt      240

gcaaggtatt ctggactgtg gctgatcctg gatagttacc acggtgatcg tggacatcca      300

tatccgtcct cggatgacgg ccttctgggt tcatgtacgg gtatgttgag ttgcaccgca      360

gtcagctcgt gcaagaatgt cggagaacta ctgccgctgg cagtcgagat tgtcagattg      420

actatccacc tcgggctctg tgtcatgaga gtccgagaga tggtggactc gacggagtca      480

tcctccggca gctggtcaat cctcgtctcg gagatcaacg aggcagatgc caccagcctg      540

attggcaatt ttgtcaagaa gcgagtaagt acagtgtacg accattggaa gaagaatatt      600

gacaatacca gggaattccc ccctcgtcgc aaccgtacat cagcgcggtt ggatcgaaag      660

gtctcaccat cagtgcacca cccgaaattc tcgacaactt tatcgaagaa ggtcttccga      720

aggagtacaa acacttcaag gctcctggag tcagtggtcc gtaccacgcg ccccatctgt      780

acaatgaccg agaaattcgc aatatcctca gcttctgctc cgaggacgtg attctgcgcc      840

acacaccacg ggttccactg gtctcgagca acacagggaa gctggtccag gtaaagagca      900

tgcgtgatct gctaaaggtg gctctggagg aaatcctctt gcgcaagatc tgctgggaca      960

aagtcaccga gtcatgcctt tccatcgttc aggctaccaa cgacaagccc tggaggattc     1020

tccctatcgc cagcaacgcc acgcaaggct tggttactgc actccagcgt atgggaaact     1080

gccagatcga ggtagacacc ggggtcggcg ctcctcaaat ggacccggcc gctcccaatg     1140

caacgggcaa tgcttcacgg tctaagatcg ccatcatcgg aatgtctggg cggttccctg     1200

aggcagatgg tatcgaggcc tggcgttccg ttctgcttag ggtatttggg aacaatcaat     1260

gttcaatgta catttaatcc acgattttat aaaacgtcat cctttgccct cccttcttat     1320

ttgccaatac caaaaatctt actccagtgg ttcggtaatc gcagagttaa atctgggctc     1380

ggtggcagat ctgcgatgct ccataaccgt tcagatgttg attggaactg ggtggggtag     1440

acagctcgaa gaccgagtga acgtatacct aagacacttt gacacggccg gaacactgta     1500

agtcccttcg tatttctccg cctgtgtgga gctaccatcc aataaccccc agctgaaaag     1560

ctgattgtga tagttcccac ttgtccgtcc gcatcggcat ccgcagctcg ggatagttcc     1620

gacctaggat tggatgcatg cggaaccgca cgagggcggg gcggaaattg acacaccact     1680

cctctccacg caccgttcaa gaggtacgcg tatagagccg tatagagcag agacggagca     1740

ctttctggta ctgtccgcac gggatgtccg cacggagagc cacaaacgag cggggccccg     1800

tacgtgctct cctaccccag gatcgcatcc ccgcatagct gaacatctat ataaagaccc     1860

ccaaggttct cagtctcacc aacatcatca accaacaatc aacagttctc tactcagtta     1920

attagaactc ttccaatcct atcacctcgc ctcaaaatga gatcccaggg taatatgtct     1980

gatcgcctgg gcgttgaagt cgactgccac tcactcggct ccaacgaatg tccgtctatg     2040

ggctccagct tctcgccttt ggaatcgccc acacctaccc ctacgagcat ctacagtcaa     2100

ggttcacttg cttccccaag ctggccagaa aacgggtcat acccgggcca cgcttacgac     2160

agaggtaccg gatcgacacc catacgcggc cacttccgtc tcgccagtat gccctcgcac     2220

gagaacatgg gtctgccacc atacagcagc ctggatgggc aggatcgcat ggcggttaca     2280

gacttcctgc cttcgtatga cgagaacgcg gatcagttct ggctcccctc ggatgttccc     2340

aagacctacg atcaccatgt ccatggactg ccatgcccgc cgtccatgca ccaatatccg     2400

ccaatgcttc gcagcaacta ccgccaccac cccgctccgt atttccctga atcggccacc     2460

aacccgtgcc tgtcgcgccc tatcttccat catcaacccg agcgcctgcc accatcgtta     2520

tccatgagcc atatgatgcc ctggatgggc catacggagt cgattgcacc ggagaccatt     2580

gctccgtccc aagttgcacc ggtaacccct cctccttcct acacggattt ctccaactct     2640

atcaacacct tcaagacgca ctcgccggac acccccatcc gctcgtgctc tctaggcact     2700

gtctctggag cggacacacc tttgagccgt ctctctggcg gcgctggtga gtacatggat     2760

gaatgccacc agtcgcctat ctaccgagat gcgtcaggcg ttcgtctgca gcggcagcca     2820

tcccgcaaga tggcgcggaa gcagccttcc aagcagagct tgtcactaga gaacctgcca     2880

tccatcatca agcaggtgca gttcaagtgc aaagaacctg gctgcaaggg tcgcttcaag     2940

cgacaggaac acctcaagcg ccacatgaag agccactcca aggaaaagcc tcatgtctgc     3000

tgggttcctg gctgccatcg agccttttca cgcagtgaca acctcaatgc ccattacacc     3060

aagacccaca gcaaacgcgg aggccgcaac cgctatgtgg ccaccttgga tgagacgagt     3120

cccgactaca acccggacta tcgggggcca cttactgctg acggtcgccc catgcccggt     3180

gggacgctgg acgagtccat gccttcccgc gagatcagta tggaatggga tgagtaaaaa     3240

aaaaaagacg aaaaaagaaa acaaagaaga gaaaaaagaa caagaaggat ttttccttca     3300

aaacgaaacg gaagctaccg acagactacg aagagattaa tgggtggatc ggaaccatga     3360

tacccttgtg acgcagtcga cacaaaattt ccttgagtga tttagatggg cacagacata     3420

tagggtccaa gagaccccgg tcggcgcttc gtggcgttat ttttccttgt cttcaacctc     3480

cccccttcct tttcctgttg tataacatgc gtcctgggtt cgaattcctt gattggatga     3540

tgcatcaccc cttcagggtc accgcagtgg ggtcgagcgt gaaggatatc cgggaggtcc     3600

tgcgtcaacg tgccgatcag gatgtcacca cccccgtccc tgcgacagcc cccaagactg     3660

ggttcgtctt caccggtcag ggagctcagt acacagggat gggcaagcaa ttgtacgagg     3720

actgtgccac attcagaagc acgattcacc gactcgattg cattgctcaa agccaagggt     3780

tcccctccat tctaccgttg attgacggta gtatgcctgt ggaagaactg agccctgtcg     3840

tgacccagct aggaaccaca tgcctgcaga tggctctggt cgactactgg aagggtcttg     3900

gtgtcactcc tgcgtttgtt ctgggacata gtctgggaga ctacgcagcg ttgaacagtg     3960

cgggcgtctt gtccaccagc gatacgattt acctctgtgg ccgtcgcgcg cagcttctca     4020

cgcagcagtg tcagatgggg acccacgcca tgcttgccgt caaggctgcc gtctccgaga     4080

ttcaacatct gctcgatcca gacgtccacg ccgtcgcctg catcaatgga ccaaccgaaa     4140

cggtcatcag cgggctcagc ggtcgaatcg atgaattggc acagcagtgc tccagccaaa     4200

atctcaagtc caccaagctc aaagtgccgt tcgcgttcca ctcggcccaa gtggacccga     4260

ttctcgagtc gttcgaagag agtgctcagg gggtcatctt ccacgaacct gccgtcccgt     4320

tcgtctctgc tctgaacgga gaggtaatca cggagtcgaa ctacagcgtg ctgggcccca     4380

cgtatatggt gaagcattgt cgggaagccg tcaatttcct tggcgctctt gaggcgaccc     4440

ggcacgccaa gttgatggat gacgccacac tctgggtcga agtgggatcc catcccattt     4500

gctcgggtat gatcaagtcc acctttggcg gccgcagag                            4539


