                         SEQUENCE LISTING

<110>  Imperial Innovations Limited
 
<120>  TREATMENT

<130>  P60758WO

<150>  GB1411027.4
<151>  2014-06-20

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  3679
<212>  DNA
<213>  Homo sapien

<400>  1
ccctcccctc ccgatcctca tccccttgcc ctcccccagc ccagggactt ttccggaaag       60

tttttatttt ccgtctgggc tctcggagaa agaagctcct ggctcagcgg ctgcaaaact      120

ttcctgctgc cgcgccgcca gcccccgccc tccgctgccc ggccctgcgc cccgccgagc      180

gatgagcgcc cctccggtcc tgcggccgcc cagtccgctg ctgcccgtgg cggcggcagc      240

tgccgcagcg gccgccgcac tggtcccagg gtccgggccc gggcccgcgc cgttcttggc      300

tcctgtcgcg gccccggtcg ggggcatctc gttccatctg cagatcggcc tgagccgtga      360

gccggtgctg ctgctgcagg actcgtccgg ggactacagc ctggcgcacg tccgcgagat      420

ggcttgctcc attgtcgacc agaagttccc tgaatgtggt ttctacggaa tgtatgataa      480

gatcctgctt tttcgccatg accctacctc tgaaaacatc cttcagctgg tgaaagcggc      540

cagtgatatc caggaaggcg atcttattga agtggtcttg tcagcttccg ccacctttga      600

agactttcag attcgtcccc acgctctctt tgttcattca tacagagctc cagctttctg      660

tgatcactgt ggagaaatgc tgtgggggct ggtacgtcaa ggtcttaaat gtgaagggtg      720

tggtctgaat taccataaga gatgtgcatt taaaataccc aacaattgca gcggtgtgag      780

gcggagaagg ctctcaaacg tttccctcac tggggtcagc accatccgca catcatctgc      840

tgaactctct acaagtgccc ctgatgagcc ccttctgcaa aaatcaccat cagagtcgtt      900

tattggtcga gagaagaggt caaattctca atcatacatt ggacgaccaa ttcaccttga      960

caagattttg atgtctaaag ttaaagtgcc gcacacattt gtcatccact cctacacccg     1020

gcccacagtg tgccagtact gcaagaagct tctgaagggg cttttcaggc agggcttgca     1080

gtgcaaagat tgcagattca actgccataa acgttgtgca ccgaaagtac caaacaactg     1140

ccttggcgaa gtgaccatta atggagattt gcttagccct ggggcagagt ctgatgtggt     1200

catggaagaa gggagtgatg acaatgatag tgaaaggaac agtgggctca tggatgatat     1260

ggaagaagca atggtccaag atgcagagat ggcaatggca gagtgccaga acgacagtgg     1320

cgagatgcaa gatccagacc cagaccacga ggacgccaac agaaccatca gtccatcaac     1380

aagcaacaat atcccactca tgagggtagt gcagtctgtc aaacacacga agaggaaaag     1440

cagcacagtc atgaaagaag gatggatggt ccactacacc agcaaggaca cgctgcggaa     1500

acggcactat tggagattgg atagcaaatg tattaccctc tttcagaatg acacaggaag     1560

caggtactac aaggaaattc ctttatctga aattttgtct ctggaaccag taaaaacttc     1620

agctttaatt cctaatgggg ccaatcctca ttgtttcgaa atcactacgg caaatgtagt     1680

gtattatgtg ggagaaaatg tggtcaatcc ttccagccca tcaccaaata acagtgttct     1740

caccagtggc gttggtgcag atgtggccag gatgtgggag atagccatcc agcatgccct     1800

tatgcccgtc attcccaagg gctcctccgt gggtacagga accaacttgc acagagatat     1860

ctctgtgagt atttcagtat caaattgcca gattcaagaa aatgtggaca tcagcacagt     1920

atatcagatt tttcctgatg aagtactggg ttctggacag tttggaattg tttatggagg     1980

aaaacatcgt aaaacaggaa gagatgtagc tattaaaatc attgacaaat tacgatttcc     2040

aacaaaacaa gaaagccagc ttcgtaatga ggttgcaatt ctacagaacc ttcatcaccc     2100

tggtgttgta aatttggagt gtatgtttga gacgcctgaa agagtgtttg ttgttatgga     2160

aaaactccat ggagacatgc tggaaatgat cttgtcaagt gaaaagggca ggttgccaga     2220

gcacataacg aagtttttaa ttactcagat actcgtggct ttgcggcacc ttcattttaa     2280

aaatatcgtt cactgtgacc tcaaaccaga aaatgtgttg ctagcctcag ctgatccttt     2340

tcctcaggtg aaactttgtg attttggttt tgcccggatc attggagaga agtctttccg     2400

gaggtcagtg gtgggtaccc ccgcttacct ggctcctgag gtcctaagga acaagggcta     2460

caatcgctct ctagacatgt ggtctgttgg ggtcatcatc tatgtaagcc taagcggcac     2520

attcccattt aatgaagatg aagacataca cgaccaaatt cagaatgcag ctttcatgta     2580

tccaccaaat ccctggaagg aaatatctca tgaagccatt gatcttatca acaatttgct     2640

gcaagtaaaa atgagaaagc gctacagtgt ggataagacc ttgagccacc cttggctaca     2700

ggactatcag acctggttag atttgcgaga gctggaatgc aaaatcgggg agcgctacat     2760

cacccatgaa agtgatgacc tgaggtggga gaagtatgca ggcgagcagg ggctgcagta     2820

ccccacacac ctgatcaatc caagtgctag ccacagtgac actcctgaga ctgaagaaac     2880

agaaatgaaa gccctcggtg agcgtgtcag catcctctga gttccatctc ctataatctg     2940

tcaaaacact gtggaactaa taaatacata cggtcaggtt taacatttgc cttgcagaac     3000

tgccattatt ttctgtcaga tgagaacaaa gctgttaaac tgttagcact gttgatgtat     3060

ctgagttgcc aagacaaatc aacagaagca tttgtatttt gtgtgaccaa ctgtgttgta     3120

ttaacaaaag ttccctgaaa cacgaaactt gttattgtga atgattcatg ttatatttaa     3180

tgcattaaac ctgtctccac tgtgcctttg caaatcagtg tttttcttac tggagcttca     3240

ttttggtaag agacagaatg tatctgtgaa gtagttctgt ttggtgtgtc ccattggtgt     3300

tgtcattgta aacaaactct tgaagagtcg attatttcca gtgttctatg aacaactcca     3360

aaacccatgt gggaaaaaaa tgaatgagga gggtagggaa taaaatccta agacacaaat     3420

gcatgaacaa gttttaatgt atagttttga atcctttgcc tgcctggtgt gcctcagtat     3480

atttaaactc aagacaatgc acctagctgt gcaagaccta gtgctcttaa gcctaaatgc     3540

cttagaaatg taaactgcca tatataacag atacatttcc ctctttctta taatactctg     3600

ttgtactatg gaaaatcagc tgctcagcaa cctttcacct ttgtgtattt ttcaataata     3660

aaaaatattc ttgtcaaaa                                                  3679


<210>  2
<211>  912
<212>  PRT
<213>  Homo sapien

<400>  2

Met Ser Ala Pro Pro Val Leu Arg Pro Pro Ser Pro Leu Leu Pro Val 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Val Pro Gly Ser Gly 
            20                  25                  30          


Pro Gly Pro Ala Pro Phe Leu Ala Pro Val Ala Ala Pro Val Gly Gly 
        35                  40                  45              


Ile Ser Phe His Leu Gln Ile Gly Leu Ser Arg Glu Pro Val Leu Leu 
    50                  55                  60                  


Leu Gln Asp Ser Ser Gly Asp Tyr Ser Leu Ala His Val Arg Glu Met 
65                  70                  75                  80  


Ala Cys Ser Ile Val Asp Gln Lys Phe Pro Glu Cys Gly Phe Tyr Gly 
                85                  90                  95      


Met Tyr Asp Lys Ile Leu Leu Phe Arg His Asp Pro Thr Ser Glu Asn 
            100                 105                 110         


Ile Leu Gln Leu Val Lys Ala Ala Ser Asp Ile Gln Glu Gly Asp Leu 
        115                 120                 125             


Ile Glu Val Val Leu Ser Ala Ser Ala Thr Phe Glu Asp Phe Gln Ile 
    130                 135                 140                 


Arg Pro His Ala Leu Phe Val His Ser Tyr Arg Ala Pro Ala Phe Cys 
145                 150                 155                 160 


Asp His Cys Gly Glu Met Leu Trp Gly Leu Val Arg Gln Gly Leu Lys 
                165                 170                 175     


Cys Glu Gly Cys Gly Leu Asn Tyr His Lys Arg Cys Ala Phe Lys Ile 
            180                 185                 190         


Pro Asn Asn Cys Ser Gly Val Arg Arg Arg Arg Leu Ser Asn Val Ser 
        195                 200                 205             


Leu Thr Gly Val Ser Thr Ile Arg Thr Ser Ser Ala Glu Leu Ser Thr 
    210                 215                 220                 


Ser Ala Pro Asp Glu Pro Leu Leu Gln Lys Ser Pro Ser Glu Ser Phe 
225                 230                 235                 240 


Ile Gly Arg Glu Lys Arg Ser Asn Ser Gln Ser Tyr Ile Gly Arg Pro 
                245                 250                 255     


Ile His Leu Asp Lys Ile Leu Met Ser Lys Val Lys Val Pro His Thr 
            260                 265                 270         


Phe Val Ile His Ser Tyr Thr Arg Pro Thr Val Cys Gln Tyr Cys Lys 
        275                 280                 285             


Lys Leu Leu Lys Gly Leu Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys 
    290                 295                 300                 


Arg Phe Asn Cys His Lys Arg Cys Ala Pro Lys Val Pro Asn Asn Cys 
305                 310                 315                 320 


Leu Gly Glu Val Thr Ile Asn Gly Asp Leu Leu Ser Pro Gly Ala Glu 
                325                 330                 335     


Ser Asp Val Val Met Glu Glu Gly Ser Asp Asp Asn Asp Ser Glu Arg 
            340                 345                 350         


Asn Ser Gly Leu Met Asp Asp Met Glu Glu Ala Met Val Gln Asp Ala 
        355                 360                 365             


Glu Met Ala Met Ala Glu Cys Gln Asn Asp Ser Gly Glu Met Gln Asp 
    370                 375                 380                 


Pro Asp Pro Asp His Glu Asp Ala Asn Arg Thr Ile Ser Pro Ser Thr 
385                 390                 395                 400 


Ser Asn Asn Ile Pro Leu Met Arg Val Val Gln Ser Val Lys His Thr 
                405                 410                 415     


Lys Arg Lys Ser Ser Thr Val Met Lys Glu Gly Trp Met Val His Tyr 
            420                 425                 430         


Thr Ser Lys Asp Thr Leu Arg Lys Arg His Tyr Trp Arg Leu Asp Ser 
        435                 440                 445             


Lys Cys Ile Thr Leu Phe Gln Asn Asp Thr Gly Ser Arg Tyr Tyr Lys 
    450                 455                 460                 


Glu Ile Pro Leu Ser Glu Ile Leu Ser Leu Glu Pro Val Lys Thr Ser 
465                 470                 475                 480 


Ala Leu Ile Pro Asn Gly Ala Asn Pro His Cys Phe Glu Ile Thr Thr 
                485                 490                 495     


Ala Asn Val Val Tyr Tyr Val Gly Glu Asn Val Val Asn Pro Ser Ser 
            500                 505                 510         


Pro Ser Pro Asn Asn Ser Val Leu Thr Ser Gly Val Gly Ala Asp Val 
        515                 520                 525             


Ala Arg Met Trp Glu Ile Ala Ile Gln His Ala Leu Met Pro Val Ile 
    530                 535                 540                 


Pro Lys Gly Ser Ser Val Gly Thr Gly Thr Asn Leu His Arg Asp Ile 
545                 550                 555                 560 


Ser Val Ser Ile Ser Val Ser Asn Cys Gln Ile Gln Glu Asn Val Asp 
                565                 570                 575     


Ile Ser Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
            580                 585                 590         


Gln Phe Gly Ile Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
        595                 600                 605             


Val Ala Ile Lys Ile Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
    610                 615                 620                 


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Asn Leu His His Pro 
625                 630                 635                 640 


Gly Val Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Arg Val Phe 
                645                 650                 655     


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
            660                 665                 670         


Ser Glu Lys Gly Arg Leu Pro Glu His Ile Thr Lys Phe Leu Ile Thr 
        675                 680                 685             


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
    690                 695                 700                 


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
705                 710                 715                 720 


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
                725                 730                 735     


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
            740                 745                 750         


Glu Val Leu Arg Asn Lys Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
        755                 760                 765             


Val Gly Val Ile Ile Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
    770                 775                 780                 


Glu Asp Glu Asp Ile His Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
785                 790                 795                 800 


Pro Pro Asn Pro Trp Lys Glu Ile Ser His Glu Ala Ile Asp Leu Ile 
                805                 810                 815     


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
            820                 825                 830         


Thr Leu Ser His Pro Trp Leu Gln Asp Tyr Gln Thr Trp Leu Asp Leu 
        835                 840                 845             


Arg Glu Leu Glu Cys Lys Ile Gly Glu Arg Tyr Ile Thr His Glu Ser 
    850                 855                 860                 


Asp Asp Leu Arg Trp Glu Lys Tyr Ala Gly Glu Gln Gly Leu Gln Tyr 
865                 870                 875                 880 


Pro Thr His Leu Ile Asn Pro Ser Ala Ser His Ser Asp Thr Pro Glu 
                885                 890                 895     


Thr Glu Glu Thr Glu Met Lys Ala Leu Gly Glu Arg Val Ser Ile Leu 
            900                 905                 910         


<210>  3
<211>  3617
<212>  DNA
<213>  Homo sapien

<400>  3
actgtcgctc cggacacttc ctcctgggcc gccgccgccg ccgccgactt aaactttgga       60

gggggaaaaa gagctactgg cgcctggcga ccctccctgc cccccaccca accccgctcc      120

ggcaacgccc ccttcctcac ggctcccgac cgaacttttc tccaacttct gcgactcgtg      180

agattccctt ctacccactc cggccctcgg gacccctctg cccatcccct ggccggtcgg      240

gtccctgcga acccctttat ctctggaatc cactcggtcc ccgactcaga gactcctgcc      300

ctccaccccc aaggtgaatt cccccgggcc gccttctgag tgggatcctc ttcttggagc      360

actggatcct gggattccct ctgccccctt ctcaatccct cctctaggga aggggccttt      420

gaatcgcggg ctctcctgat ccctgtgacc ccgacctact agatttcctc tcaggcttct      480

tggaatctca atcgctggga cctccaaccc actacttttc tcctttctga tcttctggga      540

gccctggatt ccgggcctct gacccactat agtgcctttc tctccttccc aggaccccgc      600

catcctcagg tcccctccgc ctgccagatc ttttctcgga tccccgctct cccaccacct      660

gctcacgaga tcccgcggat ctagaaccca gggtcccccg gggccccccg gccgggtccc      720

gggtgggctc caggcggccg gtccccggcc tccccccatg gccaccgccc cctcttatcc      780

cgccgggctc cctggctctc ccgggccggg gtctcctccg ccccccggcg gcctagagct      840

gcagtcgccg ccaccgctac tgccccagat cccggccccg ggttccgggg tctcctttca      900

catccagatc gggctgaccc gcgagttcgt gctgttgccc gccgcctccg agctggctca      960

tgtgaagcag ctggcctgtt ccatcgtgga ccagaagttc cctgagtgtg gcttctacgg     1020

cctttacgac aagatcctgc ttttcaaaca tgaccccacg tcggccaacc tcctgcagct     1080

ggtgcgctcg tccggagaca tccaggaggg cgacctggtg gaggtggtgc tgtcggcctc     1140

ggccaccttc gaggacttcc agatccgccc gcacgccctc acggtgcact cctatcgggc     1200

gcctgccttc tgtgatcact gcggggagat gctcttcggc ctagtgcgcc agggcctcaa     1260

gtgcgatggc tgcgggctga actaccacaa gcgctgtgcc ttcagcatcc ccaacaactg     1320

tagtggggcc cgcaaacggc gcctgtcatc cacgtctctg gccagtggcc actcggtgcg     1380

cctcggcacc tccgagtccc tgccctgcac ggctgaagag ctgagccgta gcaccaccga     1440

actcctgcct cgccgtcccc cgtcatcctc ttcctcctct tctgcctcat cgtatacggg     1500

ccgccccatt gagctggaca agatgctgct ctccaaggtc aaggtgccgc acaccttcct     1560

catccacagc tatacacggc ccaccgtttg ccaggcttgc aagaaactcc tcaagggcct     1620

cttccggcag ggcctgcaat gcaaagactg caagtttaac tgtcacaaac gctgcgccac     1680

ccgcgtccct aatgactgcc tgggggaggc ccttatcaat ggagatgtgc cgatggagga     1740

ggccaccgat ttcagcgagg ctgacaagag cgccctcatg gatgagtcag aggactccgg     1800

tgtcatccct ggctcccact cagagaatgc gctccacgcc agtgaggagg aggaaggcga     1860

gggaggcaag gcccagagct ccctggggta catcccccta atgagggtgg tgcaatcggt     1920

gcgacacacg acgcggaaat ccagcaccac gctgcgggag ggttgggtgg ttcattacag     1980

caacaaggac acgctgagaa agcggcacta ttggcgcctg gactgcaagt gtatcacgct     2040

cttccagaac aacacgacca acagatacta taaggaaatt ccgctgtcag aaatcctcac     2100

ggtggagtcc gcccagaact tcagccttgt gccgccgggc accaacccac actgctttga     2160

gatcgtcact gccaatgcca cctacttcgt gggcgagatg cctggcggga ctccgggtgg     2220

gccaagtggg cagggggctg aggccgcccg gggctgggag acagccatcc gccaggccct     2280

gatgcccgtc atccttcagg acgcacccag cgccccaggc cacgcgcccc acagacaagc     2340

ttctctgagc atctctgtgt ccaacagtca gatccaagag aatgtggaca ttgccactgt     2400

ctaccagatc ttccctgacg aagtgctggg ctcagggcag tttggagtgg tctatggagg     2460

aaaacaccgg aagacaggcc gggacgtggc agttaaggtc attgacaaac tgcgcttccc     2520

taccaagcag gagagccagc tccggaatga agtggccatt ctgcagagcc tgcggcatcc     2580

cgggatcgtg aacctggagt gcatgttcga gacgcctgag aaagtgtttg tggtgatgga     2640

gaagctgcat ggggacatgt tggagatgat cctgtccagt gagaagggcc ggctgcctga     2700

gcgcctcacc aagttcctca tcacccagat cctggtggct ttgagacacc ttcacttcaa     2760

gaacattgtc cactgtgact tgaaaccaga aaacgtgttg ctggcatcag cagacccatt     2820

tcctcaggtg aagctgtgtg actttggctt tgctcgcatc atcggcgaga agtcgttccg     2880

ccgctcagtg gtgggcacgc cggcctacct ggcacccgag gtgctgctca accagggcta     2940

caaccgctcg ctggacatgt ggtcagtggg cgtgatcatg tacgtcagcc tcagcggcac     3000

cttccctttc aacgaggatg aggacatcaa tgaccagatc cagaacgccg ccttcatgta     3060

cccggccagc ccctggagcc acatctcagc tggagccatt gacctcatca acaacctgct     3120

gcaggtgaag atgcgcaaac gctacagcgt ggacaaatct ctcagccacc cctggttaca     3180

ggagtaccag acgtggctgg acctccgaga gctggagggg aagatgggag agcgatacat     3240

cacgcatgag agtgacgacg cgcgctggga gcagtttgca gcagagcatc cgctgcctgg     3300

gtctgggctg cccacggaca gggatctcgg tggggcctgt ccaccacagg accacgacat     3360

gcaggggctg gcggagcgca tcagtgttct ctgaggtcct gtgccctcgt ccagctgctg     3420

ccctccacag cggttcttca caggatccca gcaatgaact gttctaggga aagtggcttc     3480

ctgcccaaac tggatgggac acgtggggag tggggtgggg ggagctattt ccaaggcccc     3540

tccctgtttc cccagcaatt aaaacggact catctctggc cccatggcct tgatctcagc     3600

aaaaaaaaaa aaaaaaa                                                    3617


<210>  4
<211>  878
<212>  PRT
<213>  Homo sapien

<400>  4

Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly 
1               5                   10                  15      


Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro 
            20                  25                  30          


Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His 
        35                  40                  45              


Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser 
    50                  55                  60                  


Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys 
65                  70                  75                  80  


Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe 
                85                  90                  95      


Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser 
            100                 105                 110         


Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser 
        115                 120                 125             


Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His 
    130                 135                 140                 


Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe 
145                 150                 155                 160 


Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr 
                165                 170                 175     


His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg 
            180                 185                 190         


Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg 
        195                 200                 205             


Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg 
    210                 215                 220                 


Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met 
                245                 250                 255     


Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr 
            260                 265                 270         


Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu 
        275                 280                 285             


Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys 
    290                 295                 300                 


Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile 
305                 310                 315                 320 


Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp 
                325                 330                 335     


Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly 
            340                 345                 350         


Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu 
        355                 360                 365             


Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val 
    370                 375                 380                 


Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg 
385                 390                 395                 400 


Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg 
                405                 410                 415     


His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn 
            420                 425                 430         


Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr 
        435                 440                 445             


Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro 
    450                 455                 460                 


His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe Val Gly Glu 
465                 470                 475                 480 


Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala 
                485                 490                 495     


Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile 
            500                 505                 510         


Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala 
        515                 520                 525             


Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp 
    530                 535                 540                 


Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
545                 550                 555                 560 


Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
                565                 570                 575     


Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
            580                 585                 590         


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro 
        595                 600                 605             


Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe 
    610                 615                 620                 


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
625                 630                 635                 640 


Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr 
                645                 650                 655     


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
            660                 665                 670         


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
        675                 680                 685             


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
    690                 695                 700                 


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
705                 710                 715                 720 


Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
                725                 730                 735     


Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
            740                 745                 750         


Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
        755                 760                 765             


Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile 
    770                 775                 780                 


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
785                 790                 795                 800 


Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu 
                805                 810                 815     


Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser 
            820                 825                 830         


Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly 
        835                 840                 845             


Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln 
    850                 855                 860                 


Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu 
865                 870                 875             


<210>  5
<211>  3338
<212>  DNA
<213>  Homo sapien

<400>  5
actgtcgctc cggacacttc ctcctgggcc gccgccgccg ccgccgactt aaactttgga       60

gggggaaaaa gagctactgg cgcctggcga ccctccctgc cccccaccca accccgctcc      120

ggcaacgccc ccttcctcac ggctcccgac cgaacttttc tccaacttct gcgactcgtg      180

agattccctt ctacccactc cggccctcgg gacccctctg cccatcccct ggccggtcgg      240

gtccctgcga acccctttat ctctggaatc cactcggtcc ccgactcaga gactcctgcc      300

ctccaccccc aaggaccccg ccatcctcag gtcccctccg cctgccagat cttttctcgg      360

atccccgctc tcccaccacc tgctcacgag atcccgcgga tctagaaccc agggtccccc      420

ggggcccccc ggccgggtcc cgggtgggct ccaggcggcc ggtccccggc ctccccccat      480

ggccaccgcc ccctcttatc ccgccgggct ccctggctct cccgggccgg ggtctcctcc      540

gccccccggc ggcctagagc tgcagtcgcc gccaccgcta ctgccccaga tcccggcccc      600

gggttccggg gtctcctttc acatccagat cgggctgacc cgcgagttcg tgctgttgcc      660

cgccgcctcc gagctggctc atgtgaagca gctggcctgt tccatcgtgg accagaagtt      720

ccctgagtgt ggcttctacg gcctttacga caagatcctg cttttcaaac atgaccccac      780

gtcggccaac ctcctgcagc tggtgcgctc gtccggagac atccaggagg gcgacctggt      840

ggaggtggtg ctgtcggcct cggccacctt cgaggacttc cagatccgcc cgcacgccct      900

cacggtgcac tcctatcggg cgcctgcctt ctgtgatcac tgcggggaga tgctcttcgg      960

cctagtgcgc cagggcctca agtgcgatgg ctgcgggctg aactaccaca agcgctgtgc     1020

cttcagcatc cccaacaact gtagtggggc ccgcaaacgg cgcctgtcat ccacgtctct     1080

ggccagtggc cactcggtgc gcctcggcac ctccgagtcc ctgccctgca cggctgaaga     1140

gctgagccgt agcaccaccg aactcctgcc tcgccgtccc ccgtcatcct cttcctcctc     1200

ttctgcctca tcgtatacgg gccgccccat tgagctggac aagatgctgc tctccaaggt     1260

caaggtgccg cacaccttcc tcatccacag ctatacacgg cccaccgttt gccaggcttg     1320

caagaaactc ctcaagggcc tcttccggca gggcctgcaa tgcaaagact gcaagtttaa     1380

ctgtcacaaa cgctgcgcca cccgcgtccc taatgactgc ctgggggagg cccttatcaa     1440

tggagatgtg ccgatggagg aggccaccga tttcagcgag gctgacaaga gcgccctcat     1500

ggatgagtca gaggactccg gtgtcatccc tggctcccac tcagagaatg cgctccacgc     1560

cagtgaggag gaggaaggcg agggaggcaa ggcccagagc tccctggggt acatccccct     1620

aatgagggtg gtgcaatcgg tgcgacacac gacgcggaaa tccagcacca cgctgcggga     1680

gggttgggtg gttcattaca gcaacaagga cacgctgaga aagcggcact attggcgcct     1740

ggactgcaag tgtatcacgc tcttccagaa caacacgacc aacagatact ataaggaaat     1800

tccgctgtca gaaatcctca cggtggagtc cgcccagaac ttcagccttg tgccgccggg     1860

caccaaccca cactgctttg agatcgtcac tgccaatgcc acctacttcg tgggcgagat     1920

gcctggcggg actccgggtg ggccaagtgg gcagggggct gaggccgccc ggggctggga     1980

gacagccatc cgccaggccc tgatgcccgt catccttcag gacgcaccca gcgccccagg     2040

ccacgcgccc cacagacaag cttctctgag catctctgtg tccaacagtc agatccaaga     2100

gaatgtggac attgccactg tctaccagat cttccctgac gaagtgctgg gctcagggca     2160

gtttggagtg gtctatggag gaaaacaccg gaagacaggc cgggacgtgg cagttaaggt     2220

cattgacaaa ctgcgcttcc ctaccaagca ggagagccag ctccggaatg aagtggccat     2280

tctgcagagc ctgcggcatc ccgggatcgt gaacctggag tgcatgttcg agacgcctga     2340

gaaagtgttt gtggtgatgg agaagctgca tggggacatg ttggagatga tcctgtccag     2400

tgagaagggc cggctgcctg agcgcctcac caagttcctc atcacccaga tcctggtggc     2460

tttgagacac cttcacttca agaacattgt ccactgtgac ttgaaaccag aaaacgtgtt     2520

gctggcatca gcagacccat ttcctcaggt gaagctgtgt gactttggct ttgctcgcat     2580

catcggcgag aagtcgttcc gccgctcagt ggtgggcacg ccggcctacc tggcacccga     2640

ggtgctgctc aaccagggct acaaccgctc gctggacatg tggtcagtgg gcgtgatcat     2700

gtacgtcagc ctcagcggca ccttcccttt caacgaggat gaggacatca atgaccagat     2760

ccagaacgcc gccttcatgt acccggccag cccctggagc cacatctcag ctggagccat     2820

tgacctcatc aacaacctgc tgcaggtgaa gatgcgcaaa cgctacagcg tggacaaatc     2880

tctcagccac ccctggttac aggagtacca gacgtggctg gacctccgag agctggaggg     2940

gaagatggga gagcgataca tcacgcatga gagtgacgac gcgcgctggg agcagtttgc     3000

agcagagcat ccgctgcctg ggtctgggct gcccacggac agggatctcg gtggggcctg     3060

tccaccacag gaccacgaca tgcaggggct ggcggagcgc atcagtgttc tctgaggtcc     3120

tgtgccctcg tccagctgct gccctccaca gcggttcttc acaggatccc agcaatgaac     3180

tgttctaggg aaagtggctt cctgcccaaa ctggatggga cacgtgggga gtggggtggg     3240

gggagctatt tccaaggccc ctccctgttt ccccagcaat taaaacggac tcatctctgg     3300

ccccatggcc ttgatctcag caaaaaaaaa aaaaaaaa                             3338


<210>  6
<211>  878
<212>  PRT
<213>  Homo sapien

<400>  6

Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly 
1               5                   10                  15      


Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro 
            20                  25                  30          


Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His 
        35                  40                  45              


Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser 
    50                  55                  60                  


Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys 
65                  70                  75                  80  


Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe 
                85                  90                  95      


Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser 
            100                 105                 110         


Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser 
        115                 120                 125             


Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His 
    130                 135                 140                 


Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe 
145                 150                 155                 160 


Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr 
                165                 170                 175     


His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg 
            180                 185                 190         


Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg 
        195                 200                 205             


Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg 
    210                 215                 220                 


Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met 
                245                 250                 255     


Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr 
            260                 265                 270         


Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu 
        275                 280                 285             


Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys 
    290                 295                 300                 


Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile 
305                 310                 315                 320 


Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp 
                325                 330                 335     


Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly 
            340                 345                 350         


Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu 
        355                 360                 365             


Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val 
    370                 375                 380                 


Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg 
385                 390                 395                 400 


Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg 
                405                 410                 415     


His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn 
            420                 425                 430         


Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr 
        435                 440                 445             


Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro 
    450                 455                 460                 


His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe Val Gly Glu 
465                 470                 475                 480 


Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala 
                485                 490                 495     


Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile 
            500                 505                 510         


Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala 
        515                 520                 525             


Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp 
    530                 535                 540                 


Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
545                 550                 555                 560 


Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
                565                 570                 575     


Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
            580                 585                 590         


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro 
        595                 600                 605             


Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe 
    610                 615                 620                 


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
625                 630                 635                 640 


Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr 
                645                 650                 655     


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
            660                 665                 670         


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
        675                 680                 685             


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
    690                 695                 700                 


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
705                 710                 715                 720 


Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
                725                 730                 735     


Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
            740                 745                 750         


Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
        755                 760                 765             


Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile 
    770                 775                 780                 


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
785                 790                 795                 800 


Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu 
                805                 810                 815     


Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser 
            820                 825                 830         


Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly 
        835                 840                 845             


Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln 
    850                 855                 860                 


Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu 
865                 870                 875             


<210>  7
<211>  3202
<212>  DNA
<213>  Homo sapien

<400>  7
actgtcgctc cggacacttc ctcctgggcc gccgccgccg ccgccgactt aaactttgga       60

gggggaaaaa gagctactgg cgcctggcga ccctccctgc cccccaccca accccgctcc      120

ggcaacgccc ccttcctcac ggctcccgac cgaacttttc tccaacttct gcgactcgac      180

cccgccatcc tcaggtcccc tccgcctgcc agatcttttc tcggatcccc gctctcccac      240

cacctgctca cgagatcccg cggatctaga acccagggtc ccccggggcc ccccggccgg      300

gtcccgggtg ggctccaggc ggccggtccc cggcctcccc ccatggccac cgccccctct      360

tatcccgccg ggctccctgg ctctcccggg ccggggtctc ctccgccccc cggcggccta      420

gagctgcagt cgccgccacc gctactgccc cagatcccgg ccccgggttc cggggtctcc      480

tttcacatcc agatcgggct gacccgcgag ttcgtgctgt tgcccgccgc ctccgagctg      540

gctcatgtga agcagctggc ctgttccatc gtggaccaga agttccctga gtgtggcttc      600

tacggccttt acgacaagat cctgcttttc aaacatgacc ccacgtcggc caacctcctg      660

cagctggtgc gctcgtccgg agacatccag gagggcgacc tggtggaggt ggtgctgtcg      720

gcctcggcca ccttcgagga cttccagatc cgcccgcacg ccctcacggt gcactcctat      780

cgggcgcctg ccttctgtga tcactgcggg gagatgctct tcggcctagt gcgccagggc      840

ctcaagtgcg atggctgcgg gctgaactac cacaagcgct gtgccttcag catccccaac      900

aactgtagtg gggcccgcaa acggcgcctg tcatccacgt ctctggccag tggccactcg      960

gtgcgcctcg gcacctccga gtccctgccc tgcacggctg aagagctgag ccgtagcacc     1020

accgaactcc tgcctcgccg tcccccgtca tcctcttcct cctcttctgc ctcatcgtat     1080

acgggccgcc ccattgagct ggacaagatg ctgctctcca aggtcaaggt gccgcacacc     1140

ttcctcatcc acagctatac acggcccacc gtttgccagg cttgcaagaa actcctcaag     1200

ggcctcttcc ggcagggcct gcaatgcaaa gactgcaagt ttaactgtca caaacgctgc     1260

gccacccgcg tccctaatga ctgcctgggg gaggccctta tcaatggaga tgtgccgatg     1320

gaggaggcca ccgatttcag cgaggctgac aagagcgccc tcatggatga gtcagaggac     1380

tccggtgtca tccctggctc ccactcagag aatgcgctcc acgccagtga ggaggaggaa     1440

ggcgagggag gcaaggccca gagctccctg gggtacatcc ccctaatgag ggtggtgcaa     1500

tcggtgcgac acacgacgcg gaaatccagc accacgctgc gggagggttg ggtggttcat     1560

tacagcaaca aggacacgct gagaaagcgg cactattggc gcctggactg caagtgtatc     1620

acgctcttcc agaacaacac gaccaacaga tactataagg aaattccgct gtcagaaatc     1680

ctcacggtgg agtccgccca gaacttcagc cttgtgccgc cgggcaccaa cccacactgc     1740

tttgagatcg tcactgccaa tgccacctac ttcgtgggcg agatgcctgg cgggactccg     1800

ggtgggccaa gtgggcaggg ggctgaggcc gcccggggct gggagacagc catccgccag     1860

gccctgatgc ccgtcatcct tcaggacgca cccagcgccc caggccacgc gccccacaga     1920

caagcttctc tgagcatctc tgtgtccaac agtcagatcc aagagaatgt ggacattgcc     1980

actgtctacc agatcttccc tgacgaagtg ctgggctcag ggcagtttgg agtggtctat     2040

ggaggaaaac accggaagac aggccgggac gtggcagtta aggtcattga caaactgcgc     2100

ttccctacca agcaggagag ccagctccgg aatgaagtgg ccattctgca gagcctgcgg     2160

catcccggga tcgtgaacct ggagtgcatg ttcgagacgc ctgagaaagt gtttgtggtg     2220

atggagaagc tgcatgggga catgttggag atgatcctgt ccagtgagaa gggccggctg     2280

cctgagcgcc tcaccaagtt cctcatcacc cagatcctgg tggctttgag acaccttcac     2340

ttcaagaaca ttgtccactg tgacttgaaa ccagaaaacg tgttgctggc atcagcagac     2400

ccatttcctc aggtgaagct gtgtgacttt ggctttgctc gcatcatcgg cgagaagtcg     2460

ttccgccgct cagtggtggg cacgccggcc tacctggcac ccgaggtgct gctcaaccag     2520

ggctacaacc gctcgctgga catgtggtca gtgggcgtga tcatgtacgt cagcctcagc     2580

ggcaccttcc ctttcaacga ggatgaggac atcaatgacc agatccagaa cgccgccttc     2640

atgtacccgg ccagcccctg gagccacatc tcagctggag ccattgacct catcaacaac     2700

ctgctgcagg tgaagatgcg caaacgctac agcgtggaca aatctctcag ccacccctgg     2760

ttacaggagt accagacgtg gctggacctc cgagagctgg aggggaagat gggagagcga     2820

tacatcacgc atgagagtga cgacgcgcgc tgggagcagt ttgcagcaga gcatccgctg     2880

cctgggtctg ggctgcccac ggacagggat ctcggtgggg cctgtccacc acaggaccac     2940

gacatgcagg ggctggcgga gcgcatcagt gttctctgag gtcctgtgcc ctcgtccagc     3000

tgctgccctc cacagcggtt cttcacagga tcccagcaat gaactgttct agggaaagtg     3060

gcttcctgcc caaactggat gggacacgtg gggagtgggg tggggggagc tatttccaag     3120

gcccctccct gtttccccag caattaaaac ggactcatct ctggccccat ggccttgatc     3180

tcagcaaaaa aaaaaaaaaa aa                                              3202


<210>  8
<211>  878
<212>  PRT
<213>  Homo sapien

<400>  8

Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly 
1               5                   10                  15      


Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro 
            20                  25                  30          


Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His 
        35                  40                  45              


Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser 
    50                  55                  60                  


Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys 
65                  70                  75                  80  


Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe 
                85                  90                  95      


Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser 
            100                 105                 110         


Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser 
        115                 120                 125             


Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His 
    130                 135                 140                 


Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe 
145                 150                 155                 160 


Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr 
                165                 170                 175     


His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg 
            180                 185                 190         


Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg 
        195                 200                 205             


Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg 
    210                 215                 220                 


Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met 
                245                 250                 255     


Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr 
            260                 265                 270         


Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu 
        275                 280                 285             


Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys 
    290                 295                 300                 


Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile 
305                 310                 315                 320 


Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp 
                325                 330                 335     


Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly 
            340                 345                 350         


Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu 
        355                 360                 365             


Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val 
    370                 375                 380                 


Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg 
385                 390                 395                 400 


Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg 
                405                 410                 415     


His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn 
            420                 425                 430         


Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr 
        435                 440                 445             


Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro 
    450                 455                 460                 


His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe Val Gly Glu 
465                 470                 475                 480 


Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala 
                485                 490                 495     


Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile 
            500                 505                 510         


Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala 
        515                 520                 525             


Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp 
    530                 535                 540                 


Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly 
545                 550                 555                 560 


Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp 
                565                 570                 575     


Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu 
            580                 585                 590         


Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro 
        595                 600                 605             


Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe 
    610                 615                 620                 


Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser 
625                 630                 635                 640 


Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr 
                645                 650                 655     


Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His 
            660                 665                 670         


Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe 
        675                 680                 685             


Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu 
    690                 695                 700                 


Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro 
705                 710                 715                 720 


Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser 
                725                 730                 735     


Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn 
            740                 745                 750         


Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr 
        755                 760                 765             


Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile 
    770                 775                 780                 


Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys 
785                 790                 795                 800 


Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu 
                805                 810                 815     


Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser 
            820                 825                 830         


Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly 
        835                 840                 845             


Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln 
    850                 855                 860                 


Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu 
865                 870                 875             


<210>  9
<211>  2939
<212>  DNA
<213>  Homo sapien

<400>  9
attcagcatc ccctcccacc tccgccaggt tccggaaaat tcgaggtgtc cacgctcccg       60

gagccactct ccctcccacc ccagctcccc cttccagcca ccaaacccac gccggcgccc      120

cctccccgta caattggggc gctggcatcc tgcccggctc gcgctggggt tgggaggggg      180

caggcaggaa gcgagggcct gcggggtctc tgcgtttccg ggggaaacag ccggccctgc      240

cctgggaggg tcacagtccg cccgctgctg aaggcggctc tgagcttttc cgtcgccaca      300

tccctctccc gcccctcagt tccctgagtg tggcttctac ggcctttacg acaagatcct      360

gcttttcaaa catgacccca cgtcggccaa cctcctgcag ctggtgcgct cgtccggaga      420

catccaggag ggcgacctgg tggaggtggt gctgtcggcc tcggccacct tcgaggactt      480

ccagatccgc ccgcacgccc tcacggtgca ctcctatcgg gcgcctgcct tctgtgatca      540

ctgcggggag atgctcttcg gcctagtgcg ccagggcctc aagtgcgatg gctgcgggct      600

gaactaccac aagcgctgtg ccttcagcat ccccaacaac tgtagtgggg cccgcaaacg      660

gcgcctgtca tccacgtctc tggccagtgg ccactcggtg cgcctcggca cctccgagtc      720

cctgccctgc acggctgaag agctgagccg tagcaccacc gaactcctgc ctcgccgtcc      780

cccgtcatcc tcttcctcct cttctgcctc atcgtatacg ggccgcccca ttgagctgga      840

caagatgctg ctctccaagg tcaaggtgcc gcacaccttc ctcatccaca gctatacacg      900

gcccaccgtt tgccaggctt gcaagaaact cctcaagggc ctcttccggc agggcctgca      960

atgcaaagac tgcaagttta actgtcacaa acgctgcgcc acccgcgtcc ctaatgactg     1020

cctgggggag gcccttatca atggagatgt gccgatggag gaggccaccg atttcagcga     1080

ggctgacaag agcgccctca tggatgagtc agaggactcc ggtgtcatcc ctggctccca     1140

ctcagagaat gcgctccacg ccagtgagga ggaggaaggc gagggaggca aggcccagag     1200

ctccctgggg tacatccccc taatgagggt ggtgcaatcg gtgcgacaca cgacgcggaa     1260

atccagcacc acgctgcggg agggttgggt ggttcattac agcaacaagg acacgctgag     1320

aaagcggcac tattggcgcc tggactgcaa gtgtatcacg ctcttccaga acaacacgac     1380

caacagatac tataaggaaa ttccgctgtc agaaatcctc acggtggagt ccgcccagaa     1440

cttcagcctt gtgccgccgg gcaccaaccc acactgcttt gagatcgtca ctgccaatgc     1500

cacctacttc gtgggcgaga tgcctggcgg gactccgggt gggccaagtg ggcagggggc     1560

tgaggccgcc cggggctggg agacagccat ccgccaggcc ctgatgcccg tcatccttca     1620

ggacgcaccc agcgccccag gccacgcgcc ccacagacaa gcttctctga gcatctctgt     1680

gtccaacagt cagatccaag agaatgtgga cattgccact gtctaccaga tcttccctga     1740

cgaagtgctg ggctcagggc agtttggagt ggtctatgga ggaaaacacc ggaagacagg     1800

ccgggacgtg gcagttaagg tcattgacaa actgcgcttc cctaccaagc aggagagcca     1860

gctccggaat gaagtggcca ttctgcagag cctgcggcat cccgggatcg tgaacctgga     1920

gtgcatgttc gagacgcctg agaaagtgtt tgtggtgatg gagaagctgc atggggacat     1980

gttggagatg atcctgtcca gtgagaaggg ccggctgcct gagcgcctca ccaagttcct     2040

catcacccag atcctggtgg ctttgagaca ccttcacttc aagaacattg tccactgtga     2100

cttgaaacca gaaaacgtgt tgctggcatc agcagaccca tttcctcagg tgaagctgtg     2160

tgactttggc tttgctcgca tcatcggcga gaagtcgttc cgccgctcag tggtgggcac     2220

gccggcctac ctggcacccg aggtgctgct caaccagggc tacaaccgct cgctggacat     2280

gtggtcagtg ggcgtgatca tgtacgtcag cctcagcggc accttccctt tcaacgagga     2340

tgaggacatc aatgaccaga tccagaacgc cgccttcatg tacccggcca gcccctggag     2400

ccacatctca gctggagcca ttgacctcat caacaacctg ctgcaggtga agatgcgcaa     2460

acgctacagc gtggacaaat ctctcagcca cccctggtta caggagtacc agacgtggct     2520

ggacctccga gagctggagg ggaagatggg agagcgatac atcacgcatg agagtgacga     2580

cgcgcgctgg gagcagtttg cagcagagca tccgctgcct gggtctgggc tgcccacgga     2640

cagggatctc ggtggggcct gtccaccaca ggaccacgac atgcaggggc tggcggagcg     2700

catcagtgtt ctctgaggtc ctgtgccctc gtccagctgc tgccctccac agcggttctt     2760

cacaggatcc cagcaatgaa ctgttctagg gaaagtggct tcctgcccaa actggatggg     2820

acacgtgggg agtggggtgg ggggagctat ttccaaggcc cctccctgtt tccccagcaa     2880

ttaaaacgga ctcatctctg gccccatggc cttgatctca gcaaaaaaaa aaaaaaaaa      2939


<210>  10
<211>  721
<212>  PRT
<213>  Homo sapien

<400>  10

Met Leu Phe Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly 
1               5                   10                  15      


Leu Asn Tyr His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser 
            20                  25                  30          


Gly Ala Arg Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His 
        35                  40                  45              


Ser Val Arg Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu 
    50                  55                  60                  


Leu Ser Arg Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu 
                85                  90                  95      


Asp Lys Met Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile 
            100                 105                 110         


His Ser Tyr Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu 
        115                 120                 125             


Lys Gly Leu Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn 
    130                 135                 140                 


Cys His Lys Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu 
145                 150                 155                 160 


Ala Leu Ile Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser 
                165                 170                 175     


Glu Ala Asp Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val 
            180                 185                 190         


Ile Pro Gly Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu 
        195                 200                 205             


Glu Gly Glu Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu 
    210                 215                 220                 


Met Arg Val Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr 
225                 230                 235                 240 


Thr Leu Arg Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu 
                245                 250                 255     


Arg Lys Arg His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe 
            260                 265                 270         


Gln Asn Asn Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
        275                 280                 285             


Ile Leu Thr Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly 
    290                 295                 300                 


Thr Asn Pro His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe 
305                 310                 315                 320 


Val Gly Glu Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly 
                325                 330                 335     


Ala Glu Ala Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met 
            340                 345                 350         


Pro Val Ile Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His 
        355                 360                 365             


Arg Gln Ala Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu 
    370                 375                 380                 


Asn Val Asp Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu 
385                 390                 395                 400 


Gly Ser Gly Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr 
                405                 410                 415     


Gly Arg Asp Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr 
            420                 425                 430         


Lys Gln Glu Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu 
        435                 440                 445             


Arg His Pro Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu 
    450                 455                 460                 


Lys Val Phe Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met 
465                 470                 475                 480 


Ile Leu Ser Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe 
                485                 490                 495     


Leu Ile Thr Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn 
            500                 505                 510         


Ile Val His Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala 
        515                 520                 525             


Asp Pro Phe Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile 
    530                 535                 540                 


Ile Gly Glu Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr 
545                 550                 555                 560 


Leu Ala Pro Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp 
                565                 570                 575     


Met Trp Ser Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe 
            580                 585                 590         


Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala 
        595                 600                 605             


Phe Met Tyr Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile 
    610                 615                 620                 


Asp Leu Ile Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser 
625                 630                 635                 640 


Val Asp Lys Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp 
                645                 650                 655     


Leu Asp Leu Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr 
            660                 665                 670         


His Glu Ser Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro 
        675                 680                 685             


Leu Pro Gly Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys 
    690                 695                 700                 


Pro Pro Gln Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val 
705                 710                 715                 720 


Leu 
    


<210>  11
<211>  5907
<212>  DNA
<213>  Homo sapien

<400>  11
aaagttcatc cccccagaat gaaaatgagg acatttgaga aggtgattta aggtgtggac       60

atttgagaag gtgtcctatc aaattagtaa accaaaggaa aagtactgaa tagattaatc      120

caaaacactt actgtttttt aaacgaagag gatttcacct tgacagaaaa acaactttta      180

ttcaatatgt atttcctgaa attaaagaga caagtacaga ctgaaaggaa aatagattcg      240

taaataagct acgtcaactc tatcctgctg aggatagctc agtgatgtta aatcctttac      300

aaatccctgg ttgtcttcct acagacaaga ctgctttttg atgggactga tattaagaga      360

aataggacct ttggggcatt caactccttg ataaaactta aaagtatcgg catgagtggc      420

ttaacagagg aaataaagaa gttttcaact aaatccaaaa gtgcggtcat tttctttact      480

gctgttattt taaaaacctc ttcataacca ttgaaaaaga atcgacaact attttaaaag      540

attaaagaaa ggcagatgtc tgcaaataat tcccctccat cagcccagaa gtctgtatta      600

cccacagcta ttcctgctgt gcttccagct gcttctccgt gttcaagtcc taagacggga      660

ctctctgccc gactctctaa tggaagcttc agtgcaccat cactcaccaa ctccagaggc      720

tcagtgcata cagtttcatt tctactgcaa attggcctca cacgggagag tgttaccatt      780

gaagcccagg aactgtcttt atctgctgtc aaggatcttg tgtgctccat agtttatcaa      840

aagtttccag agtgtggatt ctttggcatg tatgacaaaa ttcttctctt tcgccatgac      900

atgaactcag aaaacatttt gcagctgatt acctcagcag atgaaataca tgaaggagac      960

ctagtggaag tggttctttc agctttagcc acagtagaag acttccagat tcgtccacat     1020

actctctatg tacattctta caaagctcct actttctgtg attactgtgg tgagatgctc     1080

tggggattgg tacgtcaagg actgaaatgt gaaggctgtg gattaaatta ccataaacga     1140

tgtgccttca agattccaaa taactgtagt ggagtaagaa agagacgtct gtcaaatgta     1200

tctttaccag gacccggcct ctcagttcca agacccctac agcctgaata tgtagccctt     1260

cccagtgaag agtcacatgt ccaccaggaa ccaagtaaga gaattccttc ttggagtggt     1320

cgcccaatct ggatggaaaa gatggtaatg tgcagagtga aagttccaca cacatttgct     1380

gttcactctt acacccgtcc cacgatatgt cagtactgca agcggttact gaaaggcctc     1440

tttcgccaag gaatgcagtg taaagattgc aaattcaact gccataaacg ctgtgcatca     1500

aaagtaccaa gagactgcct tggagaggtt actttcaatg gagaaccttc cagtctggga     1560

acagatacag atataccaat ggatattgac aataatgaca taaatagtga tagtagtcgg     1620

ggtttggatg acacagaaga gccatcaccc ccagaagata agatgttctt cttggatcca     1680

tctgatctcg atgtggaaag agatgaagaa gccgttaaaa caatcagtcc atcaacaagc     1740

aataatattc cgctaatgag ggttgtacaa tccatcaagc acacaaagag gaagagcagc     1800

acaatggtga aggaagggtg gatggtccat tacaccagca gggataacct gagaaagagg     1860

cattattgga gacttgacag caaatgtcta acattatttc agaatgaatc tggatcaaag     1920

tattataagg aaattccact ttcagaaatt ctccgcatat cttcaccacg agatttcaca     1980

aacatttcac aaggcagcaa tccacactgt tttgaaatca ttactgatac tatggtatac     2040

ttcgttggtg agaacaatgg ggacagctct cataatcctg ttcttgctgc cactggagtt     2100

ggacttgatg tagcacagag ctgggaaaaa gcaattcgcc aagccctcat gcctgttact     2160

cctcaagcaa gtgtttgcac ttctccaggg caagggaaag atcacaaaga tttgtctaca     2220

agtatctctg tatctaattg tcagattcag gagaatgtgg atatcagtac tgtttaccag     2280

atctttgcag atgaggtgct tggttcaggc cagtttggca tcgtttatgg aggaaaacat     2340

agaaagactg ggagggatgt ggctattaaa gtaattgata agatgagatt ccccacaaaa     2400

caagaaagtc aactccgtaa tgaagtggct attttacaga atttgcacca tcctgggatt     2460

gtaaacctgg aatgtatgtt tgaaacccca gaacgagtct ttgtagtaat ggaaaagctg     2520

catggagata tgttggaaat gattctatcc agtgagaaaa gtcggcttcc agaacgaatt     2580

actaaattca tggtcacaca gatacttgtt gctttgagga atctgcattt taagaatatt     2640

gtgcactgtg atttaaagcc agaaaatgtg ctgcttgcat cagcagagcc atttcctcag     2700

gtgaagctgt gtgactttgg atttgcacgc atcattggtg aaaagtcatt caggagatct     2760

gtggtaggaa ctccagcata cttagcccct gaagttctcc ggagcaaagg ttacaaccgt     2820

tccctagata tgtggtcagt gggagttatc atctatgtga gcctcagtgg cacatttcct     2880

tttaatgagg atgaagatat aaatgaccaa atccaaaatg ctgcatttat gtacccacca     2940

aatccatgga gagaaatttc tggtgaagca attgatctga taaacaatct gcttcaagtg     3000

aagatgagaa aacgttacag tgttgacaaa tctcttagtc atccctggct acaggactat     3060

cagacttggc ttgaccttag agaatttgaa actcgcattg gagaacgtta cattacacat     3120

gaaagtgatg atgctcgctg ggaaatacat gcatacacac ataaccttgt atacccaaag     3180

cacttcatta tggctcctaa tccagatgat atggaagaag atccttaatc actgagctaa     3240

cctaaataag gaaggatttc attttatgga ctgatatttt gctgtgtaac ttgttctttg     3300

tagattgtca tctgcagtgc tgcaaagata tgaagaaata tgataacgaa taagtgacac     3360

cagtactgta gttcataatg agtaggtaca ggcgggaaac tgaataataa gaagtcataa     3420

tggaatcaag gtgaagcttt ttataaactt ttttagccta agcaataact ggttttgtat     3480

tttttcttaa tccttcactt taatacaata ggctcactta atttgtcttc ccatttctct     3540

ttatatatat atatataaat ataaatatat gtttgtttgt ttttttaagg aaaaacaagt     3600

caagctagca tccagttact atatagcttg gctaaattat acaagactta caagattgat     3660

tactcgacag gcttgtattt aagagataac tgtgaggtta ccattatgtg atgttactat     3720

aaggactttt aacattggtt taacaaacca tagaggcatt gaagggtttt tcttagatgc     3780

ctagaaaaag cgcactgggc tgttttacct ttctttttta ggtcaatcaa gactccaaaa     3840

tagtgattcc taaccttttt ggagttgctc tgctactctg aatatgttct atacagcata     3900

aggattgtca ccttctgtgt gttgcaacag cttctaagat aattagggac aaatgatgtt     3960

acaaaaggaa gagtactgct ggtctaagtg ctgagttgta tgtctttgca tagctccact     4020

ctgctgctaa atatgcatgt tctgactgac accatcttga tgccagtact ggattccagc     4080

attcagcagg tgcagatctc ggctttacac aatttatctt tacctagggt tcagtcagta     4140

atttctgctt tttagcaggg ccagtgcagg gtcagttaat gctacagtta ctgtatagca     4200

aacagtatcc ttttttctcc ttcccctagc ctattgggct ttgcagatat ctggagtgtt     4260

ttaaagtcaa ttattttaag cagtttgagg ggatgtgtag gagtggagca tgaaacagtt     4320

tataaggctg gggctgtatt atcagcacag caaattaaag aatgaaagaa gtacttcttt     4380

ttacatttca gctccagcag ccagctattt aaaaaatatt tttaaatatc ttccccaaag     4440

tttaagatgt gggaccatct acttgtaaga aacagtggct tatttcttca tttctcagta     4500

atcattgtaa accttttttt ttttcttctc cactctaaca aaagtaaaag aacaaaactt     4560

ttgctgaggt cttggactcc actacttgtt agttatgttg gcctggacag atggcaggtc     4620

tgtcggcagt tcctcagtct gtaaaatgaa gattatcatt cttgcctctc cctttgtcac     4680

agtgttgtcg tgaagatcag atatgtatga atgcagtcaa ataaactaaa aactaggaaa     4740

gtgttaacta tcgttgccca ccgaatttga ggtagcaaaa aaaaaaaaga atgttctggt     4800

acatgaacag actgagaagg cctttcgaca tccctgaagc tagtctcctg tctagactaa     4860

aaatatcctt gaaagaatag tagcaaacag tatgcagtac tcctgtgttc taagttcttt     4920

tatgttttag tttaccctca cagcagccat agtgttaagt cattatgagc ttcatcttaa     4980

agataagaaa actgaggcaa ggggagatta acttactgcc aaatttcaaa cagttagtag     5040

tatttgagac cagtagtatg gctctaatct tacccttagc cctcccaacc attatgctgt     5100

actatctacc cataaatacc tccaggaaac attcccctct tggtaatttg tccttctata     5160

gaagcttcaa agattaaatc aaattaattt tcaaaaaaaa ttttttttta gaaatgttat     5220

tttccctgtg atagaggatg acttcccagt ttcaccaaag tctgtttata tcaacacaca     5280

caaaatggaa taattctgag tcactaggca atcaatctac tgtggtttta ctatgtaagg     5340

tgaaaattaa ctggaacgat gtttgtttgc tatacttaca tagtcaaact ttacaagcca     5400

tgaaattaat tgcactcttt gtatttgttg ttaaatgcct aagaagtttt ctaaaaattt     5460

tgtaaaggca ctgtcagaga atctggagtt gaatgattat tccagatact gtataacctg     5520

cataactttt tgtctttaag tcgtgtttgt aaaagaagta attgctagaa acatttgata     5580

atgtacaaag tagtctataa tgactgttca gtacattttt aatatttttt tggttatatc     5640

caactttttg taaatatact ggaagcttga taataaaatg tatttcctat caccatactt     5700

ttccatgtga aaacctgagc ctatttctag tataagtatc caaagaaaag tttgacctgg     5760

ttgtgttatt ttaccagacc ttggtaaaag aactattttg gaaacagtat ttgtaaatgg     5820

aactaatgct atatttaaaa acactgattt ttttttaacc tgccaaaaat aaaaaaaagc     5880

tcattttata attttctact aaaaaaa                                         5907


<210>  12
<211>  890
<212>  PRT
<213>  Homo sapien

<400>  12

Met Ser Ala Asn Asn Ser Pro Pro Ser Ala Gln Lys Ser Val Leu Pro 
1               5                   10                  15      


Thr Ala Ile Pro Ala Val Leu Pro Ala Ala Ser Pro Cys Ser Ser Pro 
            20                  25                  30          


Lys Thr Gly Leu Ser Ala Arg Leu Ser Asn Gly Ser Phe Ser Ala Pro 
        35                  40                  45              


Ser Leu Thr Asn Ser Arg Gly Ser Val His Thr Val Ser Phe Leu Leu 
    50                  55                  60                  


Gln Ile Gly Leu Thr Arg Glu Ser Val Thr Ile Glu Ala Gln Glu Leu 
65                  70                  75                  80  


Ser Leu Ser Ala Val Lys Asp Leu Val Cys Ser Ile Val Tyr Gln Lys 
                85                  90                  95      


Phe Pro Glu Cys Gly Phe Phe Gly Met Tyr Asp Lys Ile Leu Leu Phe 
            100                 105                 110         


Arg His Asp Met Asn Ser Glu Asn Ile Leu Gln Leu Ile Thr Ser Ala 
        115                 120                 125             


Asp Glu Ile His Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Leu 
    130                 135                 140                 


Ala Thr Val Glu Asp Phe Gln Ile Arg Pro His Thr Leu Tyr Val His 
145                 150                 155                 160 


Ser Tyr Lys Ala Pro Thr Phe Cys Asp Tyr Cys Gly Glu Met Leu Trp 
                165                 170                 175     


Gly Leu Val Arg Gln Gly Leu Lys Cys Glu Gly Cys Gly Leu Asn Tyr 
            180                 185                 190         


His Lys Arg Cys Ala Phe Lys Ile Pro Asn Asn Cys Ser Gly Val Arg 
        195                 200                 205             


Lys Arg Arg Leu Ser Asn Val Ser Leu Pro Gly Pro Gly Leu Ser Val 
    210                 215                 220                 


Pro Arg Pro Leu Gln Pro Glu Tyr Val Ala Leu Pro Ser Glu Glu Ser 
225                 230                 235                 240 


His Val His Gln Glu Pro Ser Lys Arg Ile Pro Ser Trp Ser Gly Arg 
                245                 250                 255     


Pro Ile Trp Met Glu Lys Met Val Met Cys Arg Val Lys Val Pro His 
            260                 265                 270         


Thr Phe Ala Val His Ser Tyr Thr Arg Pro Thr Ile Cys Gln Tyr Cys 
        275                 280                 285             


Lys Arg Leu Leu Lys Gly Leu Phe Arg Gln Gly Met Gln Cys Lys Asp 
    290                 295                 300                 


Cys Lys Phe Asn Cys His Lys Arg Cys Ala Ser Lys Val Pro Arg Asp 
305                 310                 315                 320 


Cys Leu Gly Glu Val Thr Phe Asn Gly Glu Pro Ser Ser Leu Gly Thr 
                325                 330                 335     


Asp Thr Asp Ile Pro Met Asp Ile Asp Asn Asn Asp Ile Asn Ser Asp 
            340                 345                 350         


Ser Ser Arg Gly Leu Asp Asp Thr Glu Glu Pro Ser Pro Pro Glu Asp 
        355                 360                 365             


Lys Met Phe Phe Leu Asp Pro Ser Asp Leu Asp Val Glu Arg Asp Glu 
    370                 375                 380                 


Glu Ala Val Lys Thr Ile Ser Pro Ser Thr Ser Asn Asn Ile Pro Leu 
385                 390                 395                 400 


Met Arg Val Val Gln Ser Ile Lys His Thr Lys Arg Lys Ser Ser Thr 
                405                 410                 415     


Met Val Lys Glu Gly Trp Met Val His Tyr Thr Ser Arg Asp Asn Leu 
            420                 425                 430         


Arg Lys Arg His Tyr Trp Arg Leu Asp Ser Lys Cys Leu Thr Leu Phe 
        435                 440                 445             


Gln Asn Glu Ser Gly Ser Lys Tyr Tyr Lys Glu Ile Pro Leu Ser Glu 
    450                 455                 460                 


Ile Leu Arg Ile Ser Ser Pro Arg Asp Phe Thr Asn Ile Ser Gln Gly 
465                 470                 475                 480 


Ser Asn Pro His Cys Phe Glu Ile Ile Thr Asp Thr Met Val Tyr Phe 
                485                 490                 495     


Val Gly Glu Asn Asn Gly Asp Ser Ser His Asn Pro Val Leu Ala Ala 
            500                 505                 510         


Thr Gly Val Gly Leu Asp Val Ala Gln Ser Trp Glu Lys Ala Ile Arg 
        515                 520                 525             


Gln Ala Leu Met Pro Val Thr Pro Gln Ala Ser Val Cys Thr Ser Pro 
    530                 535                 540                 


Gly Gln Gly Lys Asp His Lys Asp Leu Ser Thr Ser Ile Ser Val Ser 
545                 550                 555                 560 


Asn Cys Gln Ile Gln Glu Asn Val Asp Ile Ser Thr Val Tyr Gln Ile 
                565                 570                 575     


Phe Ala Asp Glu Val Leu Gly Ser Gly Gln Phe Gly Ile Val Tyr Gly 
            580                 585                 590         


Gly Lys His Arg Lys Thr Gly Arg Asp Val Ala Ile Lys Val Ile Asp 
        595                 600                 605             


Lys Met Arg Phe Pro Thr Lys Gln Glu Ser Gln Leu Arg Asn Glu Val 
    610                 615                 620                 


Ala Ile Leu Gln Asn Leu His His Pro Gly Ile Val Asn Leu Glu Cys 
625                 630                 635                 640 


Met Phe Glu Thr Pro Glu Arg Val Phe Val Val Met Glu Lys Leu His 
                645                 650                 655     


Gly Asp Met Leu Glu Met Ile Leu Ser Ser Glu Lys Ser Arg Leu Pro 
            660                 665                 670         


Glu Arg Ile Thr Lys Phe Met Val Thr Gln Ile Leu Val Ala Leu Arg 
        675                 680                 685             


Asn Leu His Phe Lys Asn Ile Val His Cys Asp Leu Lys Pro Glu Asn 
    690                 695                 700                 


Val Leu Leu Ala Ser Ala Glu Pro Phe Pro Gln Val Lys Leu Cys Asp 
705                 710                 715                 720 


Phe Gly Phe Ala Arg Ile Ile Gly Glu Lys Ser Phe Arg Arg Ser Val 
                725                 730                 735     


Val Gly Thr Pro Ala Tyr Leu Ala Pro Glu Val Leu Arg Ser Lys Gly 
            740                 745                 750         


Tyr Asn Arg Ser Leu Asp Met Trp Ser Val Gly Val Ile Ile Tyr Val 
        755                 760                 765             


Ser Leu Ser Gly Thr Phe Pro Phe Asn Glu Asp Glu Asp Ile Asn Asp 
    770                 775                 780                 


Gln Ile Gln Asn Ala Ala Phe Met Tyr Pro Pro Asn Pro Trp Arg Glu 
785                 790                 795                 800 


Ile Ser Gly Glu Ala Ile Asp Leu Ile Asn Asn Leu Leu Gln Val Lys 
                805                 810                 815     


Met Arg Lys Arg Tyr Ser Val Asp Lys Ser Leu Ser His Pro Trp Leu 
            820                 825                 830         


Gln Asp Tyr Gln Thr Trp Leu Asp Leu Arg Glu Phe Glu Thr Arg Ile 
        835                 840                 845             


Gly Glu Arg Tyr Ile Thr His Glu Ser Asp Asp Ala Arg Trp Glu Ile 
    850                 855                 860                 


His Ala Tyr Thr His Asn Leu Val Tyr Pro Lys His Phe Ile Met Ala 
865                 870                 875                 880 


Pro Asn Pro Asp Asp Met Glu Glu Asp Pro 
                885                 890 


<210>  13
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  13
cuggguucua gauccgcggu u                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  14
aaggugaaau ccucuucguu u                                                 21


<210>  15
<211>  54
<212>  DNA
<213>  Homo sapien

<400>  15
ggttctggac agttcggaat aagcttattc cgaactgtcc agaacccttt tttg             54


<210>  16
<211>  57
<212>  DNA
<213>  Homo sapien

<400>  16
aattcaaaaa gggttctgga cagttcggaa taagcttatt ccgaactgtc cagaacc          57


<210>  17
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxy-thymine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxy-thymine

<400>  17
augcuguggg ggcugguacd d                                                 21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  siRNA


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  deoxy-thymine

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  deoxy-thymine

<400>  18
guaccagccc ccacagcaud d                                                 21


<210>  19
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide

<400>  19
gatccccatg ctgtgggggc tggtacttca agagagtacc agcccccaca gcattttttg       60

gaaa                                                                    64


<210>  20
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Oligonucleotide

<400>  20
agcttttcca aaaaatgctg tgggggctgg tactctcttg aagtaccagc ccccacagca       60

tggg                                                                    64


