                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  NOVEL GLP-1 RECEPTOR AGONISTS WITH CHOLESTEROL EFFLUX ACTIVITY

<130>  140029WO01

<150>  EP14172954.1
<151>  2014-06-18

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  GLP-1(7-37) receptor agonist peptide

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(35)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  2

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe Leu Gly 
        35  


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Amide

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Gly Leu 
        


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Xaa = Aib (2-Aminoisobutyric acid); Amide

<400>  4

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Gly Leu 
        


<210>  5
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<400>  5

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Gly Leu Glu Lys 
        35      


<210>  6
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  6

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Gly Leu Glu Lys 
        35      


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<400>  7

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe His Glu Lys 
        35      


<210>  8
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Xaa = Aib (2-Aminoisobutyric acid); Amide

<400>  8

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe His 
        


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  9

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


His Leu Glu Lys 
        35      


<210>  10
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  10

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe His Glu Lys 
        35      


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<400>  11

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


Gly Leu Glu Lys 
        35      


<210>  12
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Xaa = Aib (2-Aminoisobutyric acid); Amide

<400>  12

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


His Leu 
        


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<400>  13

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


Phe His Glu Lys 
        35      


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  14

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


Gly Leu Glu Lys 
        35      


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<400>  15

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


His Leu Glu Lys 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  16

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


Phe His Glu Lys 
        35      


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  17

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


His Leu Glu Lys 
        35      


<210>  18
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  18

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


Phe Leu Glu Lys 
        35      


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<400>  19

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe Leu Glu Lys 
        35      


<210>  20
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Xaa = Aib (2-Aminoisobutyric acid); Amide

<400>  20

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe Leu 
        


<210>  21
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<400>  21

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Glu Arg Val Arg Glu 
            20                  25                  30          


Phe Leu Glu Lys 
        35      


<210>  22
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analogue


<220>
<221>  PEPTIDE
<222>  (1)..(35)

<400>  22

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe Leu Gly 
        35  


