                         SEQUENCE LISTING

<110>  OURO FINO SAUDE ANIMAL LTDA
 
<120>  Complexo de poliproteinas imunogenicas de M. hyopneumoniae, gene 
       sintetico codificante do complexo de poliproteinas imunogenicas 
       de M. hyopneumoniae, composicao antigenica, processo de obtencao 
       de um complexo de poliprotenas imunogenicas de M. hyopneumoniae, 
       uso de uma composicao baseada no complexo de poliproteinas 
       imunogenicas de M. hyopneumoniae"

<130>  0003/0143-PAT

<150>  BR 10 2014 014727 6
<151>  2014-06-16

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  314
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  1

Lys Pro Ile Lys Ile Ala Leu Ile Gly Ala Gly Asn Val Gly Asn Ser 
1               5                   10                  15      


Phe Leu Tyr Ala Ala Met Asn Gln Gly Leu Ala Ser Glu Tyr Gly Ile 
            20                  25                  30          


Ile Asp Ile Asn Pro Asp Phe Ala Asp Gly Asn Ala Phe Asp Phe Glu 
        35                  40                  45              


Asp Ala Ser Ala Ser Leu Pro Phe Pro Ile Ser Val Ser Arg Tyr Glu 
    50                  55                  60                  


Tyr Lys Asp Leu Lys Asp Ala Asp Phe Ile Val Ile Thr Ala Gly Arg 
65                  70                  75                  80  


Pro Gln Lys Pro Gly Glu Thr Arg Leu Glu Leu Val Ala Asp Asn Ile 
                85                  90                  95      


Arg Ile Ile Arg Glu Ile Ala Leu Lys Val Lys Glu Ser Gly Phe Ser 
            100                 105                 110         


Gly Ile Ser Ile Ile Val Ala Asn Pro Val Asp Ile Ile Thr Arg Ala 
        115                 120                 125             


Tyr Arg Asp Ala Ser Gly Phe Ser Asp Gln Lys Val Ile Gly Ser Gly 
    130                 135                 140                 


Thr Val Leu Asp Thr Ala Arg Leu Gln Phe Ala Ile Ala Lys Arg Ala 
145                 150                 155                 160 


Lys Val Ser Pro Asn Ser Val Gln Ala Tyr Val Met Gly Glu His Gly 
                165                 170                 175     


Asp Ser Ser Phe Val Ala Tyr Ser Asn Ile Lys Ile Ala Gly Glu Tyr 
            180                 185                 190         


Phe Cys Ala Tyr Ser Lys Leu Thr Gly Ile Asp Ser Ser Asn Tyr Glu 
        195                 200                 205             


Lys Glu Leu Glu Tyr Pro Val Ser Arg Arg Ala Tyr Glu Ile Ile Asn 
    210                 215                 220                 


Arg Lys Arg Ala Thr Phe Tyr Gly Ile Gly Ala Ala Ile Ala Lys Ile 
225                 230                 235                 240 


Val Ser Asn Ile Ile Lys Asp Thr Lys Asn Ile Met Ile Ala Gly Ala 
                245                 250                 255     


Asn Leu Arg Gly Glu Tyr Gly Phe His Gly Val Asn Ile Gly Val Pro 
            260                 265                 270         


Val Val Leu Gly Ala Asn Gly Ile Glu Lys Ile Ile Glu Ile Ser Leu 
        275                 280                 285             


Asn Asp Lys Glu Lys Glu Lys Phe Ala Lys Ser Val Ala Ile Ile Asp 
    290                 295                 300                 


Lys Ile Tyr Gln Asp Ala Ile Lys Asn Ile 
305                 310                 


<210>  2
<211>  368
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  2

Lys His Lys Val Ser Asn Asp Ser Ile Arg Ile Ala Leu Thr Asp Pro 
1               5                   10                  15      


Asp Asn Pro Arg Trp Ile Ser Ala Gln Lys Asp Ile Ile Ser Tyr Val 
            20                  25                  30          


Asp Glu Thr Glu Ala Ala Thr Ser Thr Ile Thr Lys Asn Gln Asp Ala 
        35                  40                  45              


Gln Asn Asn Trp Leu Thr Gln Gln Ala Asn Leu Ser Pro Ala Pro Lys 
    50                  55                  60                  


Gly Phe Ile Ile Ala Pro Glu Asn Gly Ser Gly Val Gly Thr Ala Val 
65                  70                  75                  80  


Asn Thr Ile Ala Asp Lys Gly Ile Pro Ile Val Ala Tyr Asp Arg Leu 
                85                  90                  95      


Ile Thr Gly Ser Asp Lys Tyr Asp Trp Tyr Val Ser Phe Asp Asn Glu 
            100                 105                 110         


Lys Val Gly Glu Leu Gln Gly Leu Ser Leu Ala Ala Gly Leu Leu Gly 
        115                 120                 125             


Lys Glu Asp Gly Ala Phe Asp Ser Ile Asp Gln Met Asn Glu Tyr Leu 
    130                 135                 140                 


Lys Ser His Met Pro Gln Glu Thr Ile Ser Phe Tyr Thr Ile Ala Gly 
145                 150                 155                 160 


Ser Gln Asp Asp Asn Asn Ser Gln Tyr Phe Tyr Asn Gly Ala Met Lys 
                165                 170                 175     


Val Leu Lys Glu Leu Met Lys Asn Ser Gln Asn Lys Ile Ile Asp Leu 
            180                 185                 190         


Ser Pro Glu Gly Glu Asn Ala Val Tyr Val Pro Gly Trp Asn Tyr Gly 
        195                 200                 205             


Thr Ala Gly Gln Arg Ile Gln Ser Phe Leu Thr Ile Asn Lys Asp Pro 
    210                 215                 220                 


Ala Gly Gly Asn Lys Ile Lys Ala Val Gly Ser Lys Pro Ala Ser Ile 
225                 230                 235                 240 


Phe Lys Gly Phe Leu Ala Pro Asn Asp Gly Met Ala Glu Gln Ala Ile 
                245                 250                 255     


Thr Lys Leu Lys Leu Glu Gly Phe Asp Thr Gln Lys Ile Phe Val Thr 
            260                 265                 270         


Gly Gln Asp Tyr Asn Asp Lys Ala Lys Thr Phe Ile Lys Asp Gly Asp 
        275                 280                 285             


Gln Asn Met Thr Ile Tyr Lys Pro Asp Lys Val Leu Gly Lys Val Ala 
    290                 295                 300                 


Val Glu Val Leu Arg Val Leu Ile Ala Lys Lys Asn Lys Ala Ser Arg 
305                 310                 315                 320 


Ser Glu Val Glu Asn Glu Leu Lys Ala Lys Leu Pro Asn Ile Ser Phe 
                325                 330                 335     


Lys Tyr Asp Asn Gln Thr Tyr Lys Val Gln Gly Lys Asn Ile Asn Thr 
            340                 345                 350         


Ile Leu Val Ser Pro Val Ile Val Thr Lys Ala Asn Val Asp Asn Pro 
        355                 360                 365             


<210>  3
<211>  245
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  3

Gly Glu Ile Ser Asp Val Leu Leu Leu Asp Val Thr Pro Leu Thr Leu 
1               5                   10                  15      


Gly Ile Glu Thr Leu Gly Gly Ile Ala Thr Pro Leu Ile Pro Arg Asn 
            20                  25                  30          


Thr Thr Ile Pro Val Thr Lys Ser Gln Ile Phe Ser Thr Ala Glu Asp 
        35                  40                  45              


Asn Gln Thr Glu Val Thr Ile Ser Val Val Gln Gly Glu Arg Gln Leu 
    50                  55                  60                  


Ala Ala Asp Asn Lys Met Leu Gly Arg Phe Asn Leu Ser Gly Ile Glu 
65                  70                  75                  80  


Ala Ala Pro Arg Gly Leu Pro Gln Ile Glu Val Ser Phe Ser Ile Asp 
                85                  90                  95      


Val Asn Gly Ile Thr Thr Val Ser Ala Lys Asp Lys Lys Thr Gly Lys 
            100                 105                 110         


Glu Gln Thr Ile Thr Ile Lys Asn Thr Ser Thr Leu Ser Glu Glu Glu 
        115                 120                 125             


Ile Asn Lys Met Ile Gln Glu Ala Glu Glu Asn Arg Glu Ala Asp Ala 
    130                 135                 140                 


Leu Lys Lys Asp Lys Ile Glu Thr Thr Val Arg Ala Glu Gly Leu Ile 
145                 150                 155                 160 


Asn Gln Leu Glu Lys Ser Ile Thr Asp Gln Gly Glu Lys Ile Asp Pro 
                165                 170                 175     


Lys Gln Lys Glu Leu Leu Glu Lys Gln Ile Gln Glu Leu Lys Asp Leu 
            180                 185                 190         


Leu Lys Glu Asp Lys Thr Asp Glu Leu Lys Leu Lys Leu Asp Gln Ile 
        195                 200                 205             


Glu Ala Ala Ala Gln Ser Phe Ala Gln Ala Thr Ala Gln Gln Ala Asn 
    210                 215                 220                 


Thr Ser Glu Ser Asp Pro Lys Ala Asp Asp Ser Asn Thr Ile Asp Ala 
225                 230                 235                 240 


Glu Ile Lys Gln Asp 
                245 


<210>  4
<211>  106
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  4

Lys Gln Asp Glu Ile Lys Lys Phe Thr Phe Asp Leu Leu Tyr Lys Leu 
1               5                   10                  15      


Ile Glu Leu Glu Lys Asp Tyr Leu Tyr Asp Leu Tyr Ser Glu Val Gly 
            20                  25                  30          


Leu Ala Glu Ser Ala Ile Lys Phe Ser Ile Tyr Asn Ala Gly Lys Phe 
        35                  40                  45              


Leu Gln Asn Leu Gly Tyr Asp Ser Pro Phe Ser Lys Glu Glu Thr Glu 
    50                  55                  60                  


Ile Glu Pro Glu Ile Phe Ser Gln Leu Ser Ala Arg Ala Asp Glu Asn 
65                  70                  75                  80  


His Asp Phe Phe Ser Gly Asn Gly Ser Ser Tyr Val Met Ala Leu Ala 
                85                  90                  95      


Glu Glu Thr Glu Asp Glu Asp Trp Glu Phe 
            100                 105     


<210>  5
<211>  144
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  5

Ala Ala Lys Pro Glu Ala Ala Lys Pro Val Ala Ala Lys Pro Glu Thr 
1               5                   10                  15      


Thr Lys Pro Val Ala Ala Lys Pro Glu Ala Ala Lys Pro Glu Ala Ala 
            20                  25                  30          


Lys Pro Val Ala Ala Lys Pro Glu Ala Ala Lys Pro Val Ala Ala Lys 
        35                  40                  45              


Pro Glu Ala Ala Lys Pro Val Ala Ala Lys Pro Glu Ala Ala Lys Pro 
    50                  55                  60                  


Val Ala Ala Lys Pro Glu Ala Ala Lys Pro Val Ala Thr Asn Thr Gly 
65                  70                  75                  80  


Phe Ser Leu Thr Asn Lys Pro Lys Glu Asp Tyr Phe Pro Met Thr Glu 
                85                  90                  95      


Gly Ser Ser Asn Gln Gly Lys Lys Ser Glu Gly Thr Pro Asn Gln Gly 
            100                 105                 110         


Lys Lys Ala Glu Gly Ala Pro Asn Gln Gly Lys Lys Ala Glu Gly Thr 
        115                 120                 125             


Pro Asn Gln Gly Lys Lys Ala Glu Gly Ala Pro Ser Gln Gln Ser Pro 
    130                 135                 140                 


<210>  6
<211>  162
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  6

Ser Glu Phe Lys Glu Trp Arg Leu Asp Glu Ser Ala Phe Ser Ser Leu 
1               5                   10                  15      


Thr Phe Pro Lys Ser Gln Lys Ser Glu Gly Thr Gln Asn Gln Gly Lys 
            20                  25                  30          


Lys Ala Glu Gly Ala Pro Asn Gln Ser Lys Lys Ser Glu Glu Asn Ser 
        35                  40                  45              


Asn Lys Leu Thr Glu Tyr Ile Gln Glu Leu Gly Thr Lys Val Glu Lys 
    50                  55                  60                  


Ser Leu Lys Ser Lys Gly Lys Asn Tyr Ser Ala Glu Val Glu Lys Ile 
65                  70                  75                  80  


Ile Glu Ala Phe Ser Gly Gly Tyr Lys Phe Leu Asp Phe Ala Leu Val 
                85                  90                  95      


Glu Gln Thr Pro Lys Pro Glu Thr Pro Lys Thr Glu Ala Ala Lys Pro 
            100                 105                 110         


Glu Thr Thr Lys Pro Val Ala Ala Arg Pro Glu Ala Ala Lys Val Ala 
        115                 120                 125             


Ala Lys Pro Ser Ala Ala Lys Pro Val Ser Ser Pro Ala Pro Lys Lys 
    130                 135                 140                 


Ser Thr Leu Tyr Val Arg Val Leu Ile Arg Lys Lys Glu Asn Lys Gln 
145                 150                 155                 160 


Val Lys 
        


<210>  7
<211>  25
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  7

Gln Lys Lys Ala Val Arg Lys Glu Glu Glu Leu Glu Thr Tyr Asn Pro 
1               5                   10                  15      


Lys Asp Glu Phe Asn Ile Leu Asn Pro 
            20                  25  


<210>  8
<211>  24
<212>  PRT
<213>  Mycoplasma hyopneumoniae

<400>  8

Val Asn Asn Asp Pro Asn Tyr Lys Ile Glu Asp Leu Lys Val Ile Lys 
1               5                   10                  15      


Asn Glu Ala Gly Asp His Gln Leu 
            20                  


<210>  9
<211>  261
<212>  PRT
<213>  Pyrococcus abyssi

<400>  9

Lys Arg Ile Phe Val Gln Asn Arg Glu Leu Val Val Pro Gly Thr Leu 
1               5                   10                  15      


Leu Ala Gln Gly Pro Tyr Lys Asn Gly Arg Gly Thr Phe Arg Glu Gly 
            20                  25                  30          


Ser Arg Ile Tyr Ser Thr Val Ile Gly Leu Val Asp Ile Lys Gly Asn 
        35                  40                  45              


Thr Ile Arg Val Ile Pro Leu Glu Gly Pro Tyr Ile Pro Glu Val Gly 
    50                  55                  60                  


Asp Asn Val Ile Gly Lys Ile Val Asp Val Lys Phe Ser Ser Trp Val 
65                  70                  75                  80  


Val Asp Ile Gly Ala Pro Tyr Pro Ala Asn Leu Lys Ile Gln Asp Phe 
                85                  90                  95      


Thr Asp Glu Lys Ile Asp Leu Leu Arg Thr Asp Leu Arg Lys Phe Phe 
            100                 105                 110         


Asp Ile Gly Asp Ile Ile Tyr Ala Lys Val Lys Ala Ile Thr Glu Val 
        115                 120                 125             


Asn Asn Ile Asp Leu Thr Thr Lys Gly Met Pro Phe Asn Gly Gly Pro 
    130                 135                 140                 


Leu Lys Gly Gly Gln Ile Val Lys Ile Thr Pro Ser Arg Val Pro Arg 
145                 150                 155                 160 


Val Ile Gly Arg Gly Gly Ser Met Ile Asn Met Ile Lys Lys Leu Thr 
                165                 170                 175     


Met Thr Arg Ile Ile Val Gly Gln Asn Gly Trp Ile Trp Val Ser Gly 
            180                 185                 190         


Lys Asn Asp Ala Leu Glu Lys Leu Ala Ile Glu Ala Ile Leu Lys Ile 
        195                 200                 205             


Asp Lys Glu Ser His Thr Arg Gly Leu Thr Asp Arg Ile Lys Ala Leu 
    210                 215                 220                 


Leu Leu Ser Arg Leu Gln Glu Leu Lys Glu Lys Gly Val Ile Glu Glu 
225                 230                 235                 240 


Ile Pro Lys Leu Glu Glu Glu Pro Gln Gly Glu Asp Glu Val Asn Gly 
                245                 250                 255     


Asn Asp Gly Glu Ala 
            260     


<210>  10
<211>  244
<212>  PRT
<213>  Pyrococcus abyssi

<400>  10

Glu Lys Pro Glu Gly Leu Lys Leu Ile Asp Glu Asn Gly Arg Arg Ile 
1               5                   10                  15      


Asp Gly Arg Lys Lys Tyr Glu Leu Arg Pro Ile Lys Met Glu Val Gly 
            20                  25                  30          


Val Leu Lys Asn Ala Asn Gly Ser Ala Tyr Ile Glu Trp Gly Lys Asn 
        35                  40                  45              


Lys Ile Ile Ala Ala Val Tyr Gly Pro Arg Glu Leu His Pro Lys His 
    50                  55                  60                  


Leu Gln Arg Pro Asp Arg Ala Ile Leu Arg Val Arg Tyr Asn Met Ala 
65                  70                  75                  80  


Pro Phe Ser Val Glu Glu Arg Lys Lys Pro Gly Pro Asp Arg Arg Ser 
                85                  90                  95      


Ile Glu Ile Ser Lys Val Ile Lys Gly Ala Leu Glu Pro Ala Leu Ile 
            100                 105                 110         


Leu Glu Met Phe Pro Arg Thr Ala Ile Asp Val Phe Ile Glu Val Leu 
        115                 120                 125             


Gln Ala Asp Ala Gly Thr Arg Val Ala Gly Ile Thr Ala Ala Ser Leu 
    130                 135                 140                 


Ala Leu Ala Asp Ala Gly Ile Pro Met Arg Asp Leu Val Ala Ala Cys 
145                 150                 155                 160 


Ala Ala Gly Lys Ile Glu Gly Glu Ile Val Leu Asp Leu Asn Lys Glu 
                165                 170                 175     


Glu Asp Asn Tyr Gly Glu Ala Asp Val Pro Val Ala Ile Met Pro Leu 
            180                 185                 190         


Lys Asn Asp Ile Thr Leu Leu Gln Met Asp Gly Tyr Leu Thr Lys Asp 
        195                 200                 205             


Glu Phe Ile Glu Ala Val Lys Leu Ala Ile Lys Gly Ala Lys Ala Val 
    210                 215                 220                 


Tyr Gln Lys Gln Arg Glu Ala Leu Lys Glu Lys Tyr Leu Lys Ile Ala 
225                 230                 235                 240 


Gln Glu Val Glu 
                


<210>  11
<211>  272
<212>  PRT
<213>  Pyrococcus abyssi

<400>  11

Ser Asp Asn Glu Ile Val Ala Gly Ile Met Arg Asp His Ile Ile Asn 
1               5                   10                  15      


Leu Leu Lys Glu Gly Lys Arg Ile Asp Asp Arg Gly Phe Glu Asp Tyr 
            20                  25                  30          


Arg Pro Ile Glu Ile Glu Val Gly Val Ile Glu Lys Ala Glu Gly Ser 
        35                  40                  45              


Ala Leu Val Lys Leu Gly Ser Thr Gln Val Leu Val Gly Ile Lys Thr 
    50                  55                  60                  


Ser Leu Gly Glu Pro Phe Pro Asp Thr Pro Asn Met Gly Val Met Thr 
65                  70                  75                  80  


Thr Asn Val Glu Leu Val Pro Leu Ala Ser Pro Thr Phe Glu Pro Gly 
                85                  90                  95      


Pro Pro Asp Glu Arg Ala Ile Glu Leu Ala Arg Val Ile Asp Arg Gly 
            100                 105                 110         


Ile Arg Glu Ser Lys Ala Leu Asn Leu Glu Lys Met Val Ile Val Pro 
        115                 120                 125             


Gly Lys Ile Val Arg Val Val Phe Ile Asp Val His Val Leu Asp His 
    130                 135                 140                 


Asp Gly Asn Leu Met Asp Ala Ile Gly Ile Ala Ala Ile Ala Ala Leu 
145                 150                 155                 160 


Leu Asn Ala Arg Val Pro Lys Val Arg Tyr Asn Glu Glu Thr Gly Glu 
                165                 170                 175     


Val Glu Thr Leu Asp Glu Thr Glu Pro Leu Pro Val Glu Lys Ile Pro 
            180                 185                 190         


Val Pro Val Thr Phe Ala Lys Ile Gly Asn Ile Leu Val Val Asp Pro 
        195                 200                 205             


Ser Leu Asp Glu Glu Leu Val Met Asp Gly Lys Ile Thr Ile Thr Thr 
    210                 215                 220                 


Asp Glu Thr Gly His Ile Ser Ala Val Gln Lys Ser Glu Gly Gly Ala 
225                 230                 235                 240 


Phe Lys Leu Glu Glu Val Met Tyr Ala Val Glu Thr Ala Phe Lys Lys 
                245                 250                 255     


Ala Glu Glu Ile Arg Lys Leu Ile Leu Glu Ala Val Glu Lys Ala Lys 
            260                 265                 270         


<210>  12
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno P36

<400>  12
aaaccgatta agattgctct gattggtgca ggcaatgtag gcaactcttt cctgtacgcg       60

gcaatgaatc agggtctggc gtctgaatat ggtattattg atattaaccc ggatttcgct      120

gacggtaatg cattcgattt cgaggacgct tccgcttccc ttccgttccc aatttccgtt      180

tcccgttatg aatacaaaga cctgaaagat gcagacttta ttgttattac cgcgggccga      240

ccgcagaagc cgggtgagac ccgcctggaa ctggttgctg acaacattcg catcatccgc      300

gaaattgccc tgaaagtgaa agaaagcggt ttctctggta tttctattat tgtagctaac      360

ccggtagata ttatcacccg tgcttatcgc gatgcttccg gtttctccga ccaaaaagtt      420

atcggttccg gcaccgtgct ggacaccgcg cgtctgcaat tcgccattgc aaaacgcgcg      480

aaagttagcc cgaactcggt tcaagcatac gttatgggtg agcacggtga ctctagcttt      540

gtagcctaca gcaacattaa gattgcgggt gaatatttct ctgcgtacag caaactgacc      600

ggtattgaca gctctaacta cgaaaaagaa ctggaatacc cggtgtcccg tcgagcgtac      660

gaaattatta accgaaaacg tgcgactttc tatggtatcg gcgctgcaat tgcaaagatt      720

gtttctaaca tcattaaaga caccaagaac attatgattg ccggcgcgaa cctgcgcggt      780

gaatatggtt tccacggtgt aaacattggt gtgccggttg tactgggtgc aaacggcatc      840

gagaaaatta tcgaaatttc tctgaacgat aaagaaaaag aaaagttcgc aaaatccgta      900

gcgattattg ataaaatcta tcaggatgcg attaaaaaca tt                         942


<210>  13
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno P46

<400>  13
aaacacaaag tatctaacga ctccattcgc attgcactga ctgaccctga taacccgcgc       60

tggatttctg ctcagaaaga tattatttcc tatgttgatg aaaccgaggc ggctacttct      120

accattacca aaaaccagga tgcccagaac aactggctga cccagcaggc taacctgtcc      180

ccggcaccga aaggctttat tatcgctccg gaaaacggtt ctggtgtggg tactgccgtt      240

aacactattg ctgacaaagg tatccctatt gtagcttatg accgcctgat tactggtagc      300

gacaaatatg actggtacgt gtctttcgat aacgaaaagg ttggcgaact gcaaggcctg      360

tctctggcgg cgggtctgct gggtaaagag gacggtgctt ttgactctat tgaccagatg      420

aacgagtacc tgaaatctca catgccgcag gaaactatca gcttctacac cattgccggc      480

agccaggacg ataacaacag ccaatacttc tacaacggtg ccatgaaagt actgaaagag      540

ctgatgaaaa acagccagaa caaaattatt gacctgtctc cggaaggcga aaacgcggtt      600

tacgttccgg gttggaacta cggtactgcc ggtcaacgca ttcagtcttt cctgactatt      660

aacaaggacc cggccggtgg taataaaatt aaggctgtag gttccaagcc ggcgtctatc      720

tttaaaggtt tcctggcacc gaatgacggc atggcagagc aggcaattac caagctgaaa      780

ctggaaggct tcgataccca gaaaattttc gtaaccggtc aggattataa cgacaaagcg      840

aaaactttta ttaaagacgg cgaccagaac atgaccattt ataaaccgga caaagttctg      900

ggtaaagtgg cagtggaagt tctgcgtgtt ctgattgcga aaaaaaacaa agccagccga      960

agcgaagttg aaaacgagct gaaagcgaaa ctgccgaaca tctccttcaa gtatgataac     1020

cagacctaca aggtgcaagg caagaacatt aatactatcc tggtttctcc ggtgattgta     1080

accaaagcga atgtggacaa ccct                                            1104


<210>  14
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno HSP

<400>  14
ggtgaaattt ctgacgtgct gctgctggac gtaaccccgc tgaccctggg cattgagact       60

ctgggtggca ttgctacccc gctgattccg cgaaacacca ccattccagt gaccaaaagc      120

caaattttct ccaccgctga agataaccag accgaagtta ccatctccgt tgtgcaaggt      180

gaacgacagc tggcagccga caacaagatg ctgggtcgct ttaacctgag cggcatcgaa      240

gcggctccgc gtggtctgcc acaaattgaa gtgtccttca gcatcgatgt aaacggcatc      300

accactgttt ccgctaaaga caaaaaaacc ggtaaagaac agaccattac catcaagaat      360

acctccaccc tgtctgaaga agaaattaac aaaatgattc aggaagctga ggaaaaccgt      420

gaagccgatg cactgaaaaa agacaaaatt gaaaccaccg tacgtgcgga aggcctgatt      480

aaccagctgg aaaaatctat tactgaccag ggtgagaaaa ttgacccgaa acagaaagaa      540

ctgctggaaa agcagattca ggaactgaaa gacctgctga aagaggataa aaccgacgaa      600

ctgaaactga aactggacca gattgaagct gcggcccaat ccttcgcgca ggcaaccgcg      660

cagcaagcga acaccagcga atctgacccg aaagcggacg atagcaacac catcgacgcg      720

gagattaaac aagat                                                       735


<210>  15
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno NrdF

<400>  15
aaacaggatg aaatcaaaaa attcaccttc gacctgctgt acaaactgat tgaactggaa       60

aaagattacc tgtacgacct gtactccgaa gtgggcctgg cggaaagcgc catcaagttc      120

agcatctaca acgctggcaa attcctgcaa aacctgggct acgattctcc gttttctaaa      180

gaagagaccg aaatcgagcc ggagattttc tcccagctga gcgctcgcgc agatgagaac      240

catgacttct tctctggtaa cggcagcagc tacgtgatgg cgctggcaga ggaaaccgaa      300

gacgaagatt gggagttc                                                    318


<210>  16
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno P97R1R2

<400>  16
gcggcgaaac cggaggcagc gaaaccggtt gcggctaaac cggagaccac caaaccggtg       60

gctgctaaac cggaagcggc caaaccggaa gctgcgaaac cggtggcggc gaagccggag      120

gctgccaaac cggtagctgc taagccggaa gcggctaagc cggtggcagc aaaaccggag      180

gcggcaaaac cggtggccgc caagccggaa gctgccaagc cggttgcaac caacactggt      240

ttttctctga ccaacaaacc gaaagaagac tactttccga tgaccgaagg ctccagcaac      300

cagggtaaaa agtccgaagg tactccgaac cagggtaaga aagcggaggg tgcaccgaac      360

cagggcaaaa aagcggaagg caccccgaac caaggtaaaa aagcagaggg tgcgccgagc      420

cagcagagcc cgaccaccga a                                                441


<210>  17
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno MHP271

<400>  17
ccgaaatccc aaaaatctga aggtactcaa aaccagggta aaaaagctga aggtgccccg       60

aatcagtcca aaaaaagcga ggaaaactcc aacaaactga ctgaatacat tcaagaactg      120

ggcactaaag tggagaagag cctgaaatct aaaggtaaaa actacagcgc agaagttgag      180

aagattattg aagcattcag cggcggctat aagttcctgg atttcgcgct ggttgaacag      240

accccgaaac cggaaacccc gaaaactgaa gctgctaaac cggaaactac taaaccggtg      300

gcggcgcgcc cggaagctgc gaaagttgct gcgaaaccgt ccgctgcgaa acctgtttcc      360

agcccggcgc cgaaaaaatc taccctgtac gtg                                   393


<210>  18
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno P216-A

<400>  18
ggccagaaga aggcggtacg taaggaagag gaactggaaa cctacaaccc gaaagacgag       60

tttaatatcc tgaacccg                                                     78


<210>  19
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene sintetico para o antigeno P216-A

<400>  19
gtgaacaacg acccgaacta caaaattgaa gacctgaagg tgattaagaa cgaggcaggt       60

gaccatcagc tt                                                           72


<210>  20
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene para proteina Rrp4 do exossomo de P. abyssi

<400>  20
aaacgtatct tcgtacagaa tcgtgaactg gtggtgccgg gtactctgct ggcccagggt       60

ccttataaaa acggtcgtgg cactttccgt gaaggtagcc gtatctactc taccgttatc      120

ggtctggtgg acatcaaagg caacaccatt cgtgtgattc ctctggaggg tccgtacatc      180

ccggaagtag gtgacaacgt tatcggtaaa attgtggacg ttaagttctc tagctgggtt      240

gtagacattg gtgcgccgta tccggccaac ttgaagattc aggacttcac tgatgaaaaa      300

attgatttgc tgcgtactga ccttcgtaag ttctttgata ttggtgacat tatctacgct      360

aaagtaaaag ccatcaccga agttaacaac attgacctga cgaccaaagg catgccgttt      420

aacggtggtc cgctgaaagg tggtcaaatc gtgaaaatta cgccgtctcg tgtgccgcgt      480

gttatcggtc gcggtggcag catgattaac atgattaaaa aactgaccat gactcgtatt      540

attgttggcc aaaacggctg gatttgggtg tctggcaaaa acgatgcgct ggaaaaactt      600

gctattgagg ccattctgaa aattgacaaa gagtctcata cccgtggtct gactgaccgt      660

attaaagcgc tgctgctgtc ccgcctgcaa gaactgaaag aaaaaggtgt tattgaagag      720

attccgaaac tggaagaaga gccgcagggc gaagatgaag taaacggcaa tgacggtgaa      780

gct                                                                    783


<210>  21
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene para proteina Rrp41 do exossomo de P. abyssi

<400>  21
gagaaaccgg aaggtctgaa actgattgat gaaaacggcc gccgtattga cggtcgtaaa       60

aaatacgaac tgcgtccgat taaaatggaa gtgggtgtac tgaaaaacgc taacggttcc      120

gcgtacatcg aatggggcaa aaacaaaatt atcgcagcgg tttacggtcc gcgtgaactc      180

cacccgaaac accttcagcg tccggaccgc gccatcctgc gtgtacgtta caacatggcc      240

ccgttctctg ttgaagagac taagagcccg ggtccggacc gtcgtagcat tgagatttct      300

aaagtaatta aaggtgcgct ggaaccggca cttattctgg aaatgttccc gcgtactgct      360

attgatgtat tcatcgaagt tctgcaagcg gatgccggta cgcgcgttgc aggtatcacc      420

gcggctagcc tggcactggc cgacgctggt attccgatgc gcgacctggt tgccgcttgt      480

gcggcgggta aaatcgaagg cgaaattgtt ctggacctga acaaagaaga agataactac      540

ggcgaagcgg acgtgccggt agctatcatg ccgctgaaga acgatattac cctgctgcaa      600

atggatggtt acctgaccaa ggacgagttc atcgaggcgg ttaaactggc tattaaaggt      660

gctaaggcgg tgtatcagaa acagcgtgaa gcactgaaag aaaagtatct gaaaattgcc      720

caggaagttg ag                                                          732


<210>  22
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene para proteina Rrp42 do exossomo de P. abyssi

<400>  22
tctgataatg aaatcgtggc gggtattatg cgcgaccata ttattaacct gcttaaggaa       60

ggtaaacgta ttgacgaccg cggtttcgaa gattaccgcc cgattgaaat tgaggtaggt      120

gttattgaaa aagcggaggg tagcgcgctg gtgaaactgg gtagcactca ggttctggtg      180

ggtattaaaa cctctctggg cgagccgttt ccggacaccc cgaacatggg cgtgatgacc      240

accaatgttg aacttgttcc gctggcgtct ccgactttcg aaccgggccc gccggacgag      300

cgtgctatcg aactggcacg tgttattgac cgtggtattc gtgagtccaa agcactgaat      360

ctggaaaaaa tggttatcgt gccgggcaaa attgttcgcg tagtttttat cgacgttcac      420

gttcttgacc acgacggtaa cctgatggac gccatcggta ttgcagctat cgccgcactg      480

ctgaacgcac gtgttccgaa agttcgctac aacgaagaaa cgggtgaagt tgaaaccctg      540

gatgaaactg aaccgctgcc ggttgaaaag attccggttc cggttacttt cgctaaaatt      600

ggtaatatcc tggtagttga cccgagcctg gatgaagagc tcgtgatgga cggcaaaatt      660

accattacca ctgacgaaac cggccatatt tctgccgttc agaaatctga aggtggcgct      720

ttcaaactgg aagaagtaat gtacgcggtg gaaactgcat tcaagaaggc ggaagaaatc      780

cgtaaactga ttctggaagc tgttgagaag gccaaacag                             819


<210>  23
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promotor para o gene de Rrp41

<400>  23
taactgcagg cttaagtcga acagaaagta atcgtattgt acacggccgc aacttcgaaa       60

ttaatacgac tcactatagg gagaccacaa cggtttccca tcttagtata ttagttaagt      120

ataagaagga gatataaaca tggca                                            145


<210>  24
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promotor para o gene de Rrp42

<400>  24
taagaattcg cttaagtcga acagaaagta atcgtattgt acacggccgc ataatcgaaa       60

ttaatacgac tcactatagg gagaccacaa cggtttccca tcttagtata ttagttaagt      120

ataagaagga gatataccat gggt                                             144


<210>  25
<211>  6764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gene para o complexo EXOMYC


<220>
<221>  CDS
<222>  (4)..(2217)
<223>  Poliproteina 1: Rrp4-P36-MHP271

<220>
<221>  CDS
<222>  (2354)..(4651)
<223>  Poliproteina 2: Rrp41-P46-P97R1R2

<220>
<221>  CDS
<222>  (4787)..(6760)
<223>  Poliproteina 3: Rrp42-HSP-NrdF

<400>  25
cat atg gcc aaa cgt atc ttc gta cag aat cgt gaa ctg gtg gtg ccg         48
    Met Ala Lys Arg Ile Phe Val Gln Asn Arg Glu Leu Val Val Pro           
    1               5                   10                  15            

ggt act ctg ctg gcc cag ggt cct tat aaa aac ggt cgt ggc act ttc         96
Gly Thr Leu Leu Ala Gln Gly Pro Tyr Lys Asn Gly Arg Gly Thr Phe           
                20                  25                  30                

cgt gaa ggt agc cgt atc tac tct acc gtt atc ggt ctg gtg gac atc        144
Arg Glu Gly Ser Arg Ile Tyr Ser Thr Val Ile Gly Leu Val Asp Ile           
            35                  40                  45                    

aaa ggc aac acc att cgt gtg att cct ctg gag ggt ccg tac atc ccg        192
Lys Gly Asn Thr Ile Arg Val Ile Pro Leu Glu Gly Pro Tyr Ile Pro           
        50                  55                  60                        

gaa gta ggt gac aac gtt atc ggt aaa att gtg gac gtt aag ttc tct        240
Glu Val Gly Asp Asn Val Ile Gly Lys Ile Val Asp Val Lys Phe Ser           
    65                  70                  75                            

agc tgg gtt gta gac att ggt gcg ccg tat ccg gcc aac ttg aag att        288
Ser Trp Val Val Asp Ile Gly Ala Pro Tyr Pro Ala Asn Leu Lys Ile           
80                  85                  90                  95            

cag gac ttc act gat gaa aaa att gat ttg ctg cgt act gac ctt cgt        336
Gln Asp Phe Thr Asp Glu Lys Ile Asp Leu Leu Arg Thr Asp Leu Arg           
                100                 105                 110               

aag ttc ttt gat att ggt gac att atc tac gct aaa gta aaa gcc atc        384
Lys Phe Phe Asp Ile Gly Asp Ile Ile Tyr Ala Lys Val Lys Ala Ile           
            115                 120                 125                   

acc gaa gtt aac aac att gac ctg acg acc aaa ggc atg ccg ttt aac        432
Thr Glu Val Asn Asn Ile Asp Leu Thr Thr Lys Gly Met Pro Phe Asn           
        130                 135                 140                       

ggt ggt ccg ctg aaa ggt ggt caa atc gtg aaa att acg ccg tct cgt        480
Gly Gly Pro Leu Lys Gly Gly Gln Ile Val Lys Ile Thr Pro Ser Arg           
    145                 150                 155                           

gtg ccg cgt gtt atc ggt cgc ggt ggc agc atg att aac atg att aaa        528
Val Pro Arg Val Ile Gly Arg Gly Gly Ser Met Ile Asn Met Ile Lys           
160                 165                 170                 175           

aaa ctg acc atg act cgt att att gtt ggc caa aac ggc tgg att tgg        576
Lys Leu Thr Met Thr Arg Ile Ile Val Gly Gln Asn Gly Trp Ile Trp           
                180                 185                 190               

gtg tct ggc aaa aac gat gcg ctg gaa aaa ctt gct att gag gcc att        624
Val Ser Gly Lys Asn Asp Ala Leu Glu Lys Leu Ala Ile Glu Ala Ile           
            195                 200                 205                   

ctg aaa att gac aaa gag tct cat acc cgt ggt ctg act gac cgt att        672
Leu Lys Ile Asp Lys Glu Ser His Thr Arg Gly Leu Thr Asp Arg Ile           
        210                 215                 220                       

aaa gcg ctg ctg ctg tcc cgc ctg caa gaa ctg aaa gaa aaa ggt gtt        720
Lys Ala Leu Leu Leu Ser Arg Leu Gln Glu Leu Lys Glu Lys Gly Val           
    225                 230                 235                           

att gaa gag att ccg aaa ctg gaa gaa gag ccg cag ggc gaa gat gaa        768
Ile Glu Glu Ile Pro Lys Leu Glu Glu Glu Pro Gln Gly Glu Asp Glu           
240                 245                 250                 255           

gta aac ggc aat gac ggt gaa gct aga tct ggt gtg aac aac gac ccg        816
Val Asn Gly Asn Asp Gly Glu Ala Arg Ser Gly Val Asn Asn Asp Pro           
                260                 265                 270               

aac tac aaa att gaa gac ctg aag gtg att aag aac gag gca ggt gac        864
Asn Tyr Lys Ile Glu Asp Leu Lys Val Ile Lys Asn Glu Ala Gly Asp           
            275                 280                 285                   

cat cag ctt ggc tcc aaa ccg att aag att gct ctg att ggt gca ggc        912
His Gln Leu Gly Ser Lys Pro Ile Lys Ile Ala Leu Ile Gly Ala Gly           
        290                 295                 300                       

aat gta ggc aac tct ttc ctg tac gcg gca atg aat cag ggt ctg gcg        960
Asn Val Gly Asn Ser Phe Leu Tyr Ala Ala Met Asn Gln Gly Leu Ala           
    305                 310                 315                           

tct gaa tat ggt att att gat att aac ccg gat ttc gct gac ggt aat       1008
Ser Glu Tyr Gly Ile Ile Asp Ile Asn Pro Asp Phe Ala Asp Gly Asn           
320                 325                 330                 335           

gca ttc gat ttc gag gac gct tcc gct tcc ctt ccg ttc cca att tcc       1056
Ala Phe Asp Phe Glu Asp Ala Ser Ala Ser Leu Pro Phe Pro Ile Ser           
                340                 345                 350               

gtt tcc cgt tat gaa tac aaa gac ctg aaa gat gca gac ttt att gtt       1104
Val Ser Arg Tyr Glu Tyr Lys Asp Leu Lys Asp Ala Asp Phe Ile Val           
            355                 360                 365                   

att acc gcg ggc cga ccg cag aag ccg ggt gag acc cgc ctg gaa ctg       1152
Ile Thr Ala Gly Arg Pro Gln Lys Pro Gly Glu Thr Arg Leu Glu Leu           
        370                 375                 380                       

gtt gct gac aac att cgc atc atc cgc gaa att gcc ctg aaa gtg aaa       1200
Val Ala Asp Asn Ile Arg Ile Ile Arg Glu Ile Ala Leu Lys Val Lys           
    385                 390                 395                           

gaa agc ggt ttc tct ggt att tct att att gta gct aac ccg gta gat       1248
Glu Ser Gly Phe Ser Gly Ile Ser Ile Ile Val Ala Asn Pro Val Asp           
400                 405                 410                 415           

att atc acc cgt gct tat cgc gat gct tcc ggt ttc tcc gac caa aaa       1296
Ile Ile Thr Arg Ala Tyr Arg Asp Ala Ser Gly Phe Ser Asp Gln Lys           
                420                 425                 430               

gtt atc ggt tcc ggc acc gtg ctg gac acc gcg cgt ctg caa ttc gcc       1344
Val Ile Gly Ser Gly Thr Val Leu Asp Thr Ala Arg Leu Gln Phe Ala           
            435                 440                 445                   

att gca aaa cgc gcg aaa gtt agc ccg aac tcg gtt caa gca tac gtt       1392
Ile Ala Lys Arg Ala Lys Val Ser Pro Asn Ser Val Gln Ala Tyr Val           
        450                 455                 460                       

atg ggt gag cac ggt gac tct agc ttt gta gcc tac agc aac att aag       1440
Met Gly Glu His Gly Asp Ser Ser Phe Val Ala Tyr Ser Asn Ile Lys           
    465                 470                 475                           

att gcg ggt gaa tat ttc tct gcg tac agc aaa ctg acc ggt att gac       1488
Ile Ala Gly Glu Tyr Phe Ser Ala Tyr Ser Lys Leu Thr Gly Ile Asp           
480                 485                 490                 495           

agc tct aac tac gaa aaa gaa ctg gaa tac ccg gtg tcc cgt cga gcg       1536
Ser Ser Asn Tyr Glu Lys Glu Leu Glu Tyr Pro Val Ser Arg Arg Ala           
                500                 505                 510               

tac gaa att att aac cga aaa cgt gcg act ttc tat ggt atc ggc gct       1584
Tyr Glu Ile Ile Asn Arg Lys Arg Ala Thr Phe Tyr Gly Ile Gly Ala           
            515                 520                 525                   

gca att gca aag att gtt tct aac atc att aaa gac acc aag aac att       1632
Ala Ile Ala Lys Ile Val Ser Asn Ile Ile Lys Asp Thr Lys Asn Ile           
        530                 535                 540                       

atg att gcc ggc gcg aac ctg cgc ggt gaa tat ggt ttc cac ggt gta       1680
Met Ile Ala Gly Ala Asn Leu Arg Gly Glu Tyr Gly Phe His Gly Val           
    545                 550                 555                           

aac att ggt gtg ccg gtt gta ctg ggt gca aac ggc atc gag aaa att       1728
Asn Ile Gly Val Pro Val Val Leu Gly Ala Asn Gly Ile Glu Lys Ile           
560                 565                 570                 575           

atc gaa att tct ctg aac gat aaa gaa aaa gaa aag ttc gca aaa tcc       1776
Ile Glu Ile Ser Leu Asn Asp Lys Glu Lys Glu Lys Phe Ala Lys Ser           
                580                 585                 590               

gta gcg att att gat aaa atc tat cag gat gcg att aaa aac att ccg       1824
Val Ala Ile Ile Asp Lys Ile Tyr Gln Asp Ala Ile Lys Asn Ile Pro           
            595                 600                 605                   

aaa tcc caa aaa tct gaa ggt act caa aac cag ggt aaa aaa gct gaa       1872
Lys Ser Gln Lys Ser Glu Gly Thr Gln Asn Gln Gly Lys Lys Ala Glu           
        610                 615                 620                       

ggt gcc ccg aat cag tcc aaa aaa agc gag gaa aac tcc aac aaa ctg       1920
Gly Ala Pro Asn Gln Ser Lys Lys Ser Glu Glu Asn Ser Asn Lys Leu           
    625                 630                 635                           

act gaa tac att caa gaa ctg ggc act aaa gtg gag aag agc ctg aaa       1968
Thr Glu Tyr Ile Gln Glu Leu Gly Thr Lys Val Glu Lys Ser Leu Lys           
640                 645                 650                 655           

tct aaa ggt aaa aac tac agc gca gaa gtt gag aag att att gaa gca       2016
Ser Lys Gly Lys Asn Tyr Ser Ala Glu Val Glu Lys Ile Ile Glu Ala           
                660                 665                 670               

ttc agc ggc ggc tat aag ttc ctg gat ttc gcg ctg gtt gaa cag acc       2064
Phe Ser Gly Gly Tyr Lys Phe Leu Asp Phe Ala Leu Val Glu Gln Thr           
            675                 680                 685                   

ccg aaa ccg gaa acc ccg aaa act gaa gct gct aaa ccg gaa act act       2112
Pro Lys Pro Glu Thr Pro Lys Thr Glu Ala Ala Lys Pro Glu Thr Thr           
        690                 695                 700                       

aaa ccg gtg gcg gcg cgc ccg gaa gct gcg aaa gtt gct gcg aaa ccg       2160
Lys Pro Val Ala Ala Arg Pro Glu Ala Ala Lys Val Ala Ala Lys Pro           
    705                 710                 715                           

tcc gct gcg aaa cct gtt tcc agc ccg gcg ccg aaa aaa tct acc ctg       2208
Ser Ala Ala Lys Pro Val Ser Ser Pro Ala Pro Lys Lys Ser Thr Leu           
720                 725                 730                 735           

tac gtg taa ctgcaggctt aagtcgaaca gaaagtaatc gtattgtaca               2257
Tyr Val                                                                   
                                                                          

cggccgcaac ttcgaaatta atacgactca ctatagggag accacaacgg tttcccatct     2317

tagtatatta gttaagtata agaaggagat ataaac atg gca gag aaa ccg gaa       2371
                                        Met Ala Glu Lys Pro Glu           
                                                740                       

ggt ctg aaa ctg att gat gaa aac ggc cgc cgt att gac ggt cgt aaa       2419
Gly Leu Lys Leu Ile Asp Glu Asn Gly Arg Arg Ile Asp Gly Arg Lys           
    745                 750                 755                           

aaa tac gaa ctg cgt ccg att aaa atg gaa gtg ggt gta ctg aaa aac       2467
Lys Tyr Glu Leu Arg Pro Ile Lys Met Glu Val Gly Val Leu Lys Asn           
760                 765                 770                 775           

gct aac ggt tcc gcg tac atc gaa tgg ggc aaa aac aaa att atc gca       2515
Ala Asn Gly Ser Ala Tyr Ile Glu Trp Gly Lys Asn Lys Ile Ile Ala           
                780                 785                 790               

gcg gtt tac ggt ccg cgt gaa ctc cac ccg aaa cac ctt cag cgt ccg       2563
Ala Val Tyr Gly Pro Arg Glu Leu His Pro Lys His Leu Gln Arg Pro           
            795                 800                 805                   

gac cgc gcc atc ctg cgt gta cgt tac aac atg gcc ccg ttc tct gtt       2611
Asp Arg Ala Ile Leu Arg Val Arg Tyr Asn Met Ala Pro Phe Ser Val           
        810                 815                 820                       

gaa gag act aag agc ccg ggt ccg gac cgt cgt agc att gag att tct       2659
Glu Glu Thr Lys Ser Pro Gly Pro Asp Arg Arg Ser Ile Glu Ile Ser           
    825                 830                 835                           

aaa gta att aaa ggt gcg ctg gaa ccg gca ctt att ctg gaa atg ttc       2707
Lys Val Ile Lys Gly Ala Leu Glu Pro Ala Leu Ile Leu Glu Met Phe           
840                 845                 850                 855           

ccg cgt act gct att gat gta ttc atc gaa gtt ctg caa gcg gat gcc       2755
Pro Arg Thr Ala Ile Asp Val Phe Ile Glu Val Leu Gln Ala Asp Ala           
                860                 865                 870               

ggt acg cgc gtt gca ggt atc acc gcg gct agc ctg gca ctg gcc gac       2803
Gly Thr Arg Val Ala Gly Ile Thr Ala Ala Ser Leu Ala Leu Ala Asp           
            875                 880                 885                   

gct ggt att ccg atg cgc gac ctg gtt gcc gct tgt gcg gcg ggt aaa       2851
Ala Gly Ile Pro Met Arg Asp Leu Val Ala Ala Cys Ala Ala Gly Lys           
        890                 895                 900                       

atc gaa ggc gaa att gtt ctg gac ctg aac aaa gaa gaa gat aac tac       2899
Ile Glu Gly Glu Ile Val Leu Asp Leu Asn Lys Glu Glu Asp Asn Tyr           
    905                 910                 915                           

ggc gaa gcg gac gtg ccg gta gct atc atg ccg ctg aag aac gat att       2947
Gly Glu Ala Asp Val Pro Val Ala Ile Met Pro Leu Lys Asn Asp Ile           
920                 925                 930                 935           

acc ctg ctg caa atg gat ggt tac ctg acc aag gac gag ttc atc gag       2995
Thr Leu Leu Gln Met Asp Gly Tyr Leu Thr Lys Asp Glu Phe Ile Glu           
                940                 945                 950               

gcg gtt aaa ctg gct att aaa ggt gct aag gcg gtg tat cag aaa cag       3043
Ala Val Lys Leu Ala Ile Lys Gly Ala Lys Ala Val Tyr Gln Lys Gln           
            955                 960                 965                   

cgt gaa gca ctg aaa gaa aag tat ctg aaa att gcc cag gaa gtt gag       3091
Arg Glu Ala Leu Lys Glu Lys Tyr Leu Lys Ile Ala Gln Glu Val Glu           
        970                 975                 980                       

gga tcc cct aaa cac aaa gta tct aac gac tcc att cgc att gca ctg       3139
Gly Ser Pro Lys His Lys Val Ser Asn Asp Ser Ile Arg Ile Ala Leu           
    985                 990                 995                           

act  gac cct gat aac ccg  cgc tgg att tct gct  cag aaa gat att        3184
Thr  Asp Pro Asp Asn Pro  Arg Trp Ile Ser Ala  Gln Lys Asp Ile            
1000                 1005                 1010                            

att  tcc tat gtt gat gaa  acc gag gcg gct act  tct acc att acc        3229
Ile  Ser Tyr Val Asp Glu  Thr Glu Ala Ala Thr  Ser Thr Ile Thr            
1015                 1020                 1025                            

aaa  aac cag gat gcc cag  aac aac tgg ctg acc  cag cag gct aac        3274
Lys  Asn Gln Asp Ala Gln  Asn Asn Trp Leu Thr  Gln Gln Ala Asn            
1030                 1035                 1040                            

ctg  tcc ccg gca ccg aaa  ggc ttt att atc gct  ccg gaa aac ggt        3319
Leu  Ser Pro Ala Pro Lys  Gly Phe Ile Ile Ala  Pro Glu Asn Gly            
1045                 1050                 1055                            

tct  ggt gtg ggt act gcc  gtt aac act att gct  gac aaa ggt atc        3364
Ser  Gly Val Gly Thr Ala  Val Asn Thr Ile Ala  Asp Lys Gly Ile            
1060                 1065                 1070                            

cct  att gta gct tat gac  cgc ctg att act ggt  agc gac aaa tat        3409
Pro  Ile Val Ala Tyr Asp  Arg Leu Ile Thr Gly  Ser Asp Lys Tyr            
1075                 1080                 1085                            

gac  tgg tac gtg tct ttc  gat aac gaa aag gtt  ggc gaa ctg caa        3454
Asp  Trp Tyr Val Ser Phe  Asp Asn Glu Lys Val  Gly Glu Leu Gln            
1090                 1095                 1100                            

ggc  ctg tct ctg gcg gcg  ggt ctg ctg ggt aaa  gag gac ggt gct        3499
Gly  Leu Ser Leu Ala Ala  Gly Leu Leu Gly Lys  Glu Asp Gly Ala            
1105                 1110                 1115                            

ttt  gac tct att gac cag  atg aac gag tac ctg  aaa tct cac atg        3544
Phe  Asp Ser Ile Asp Gln  Met Asn Glu Tyr Leu  Lys Ser His Met            
1120                 1125                 1130                            

ccg  cag gaa act atc agc  ttc tac acc att gcc  ggc agc cag gac        3589
Pro  Gln Glu Thr Ile Ser  Phe Tyr Thr Ile Ala  Gly Ser Gln Asp            
1135                 1140                 1145                            

gat  aac aac agc caa tac  ttc tac aac ggt gcc  atg aaa gta ctg        3634
Asp  Asn Asn Ser Gln Tyr  Phe Tyr Asn Gly Ala  Met Lys Val Leu            
1150                 1155                 1160                            

aaa  gag ctg atg aaa aac  agc cag aac aaa att  att gac ctg tct        3679
Lys  Glu Leu Met Lys Asn  Ser Gln Asn Lys Ile  Ile Asp Leu Ser            
1165                 1170                 1175                            

ccg  gaa ggc gaa aac gcg  gtt tac gtt ccg ggt  tgg aac tac ggt        3724
Pro  Glu Gly Glu Asn Ala  Val Tyr Val Pro Gly  Trp Asn Tyr Gly            
1180                 1185                 1190                            

act  gcc ggt caa cgc att  cag tct ttc ctg act  att aac aag gac        3769
Thr  Ala Gly Gln Arg Ile  Gln Ser Phe Leu Thr  Ile Asn Lys Asp            
1195                 1200                 1205                            

ccg  gcc ggt ggt aat aaa  att aag gct gta ggt  tcc aag ccg gcg        3814
Pro  Ala Gly Gly Asn Lys  Ile Lys Ala Val Gly  Ser Lys Pro Ala            
1210                 1215                 1220                            

tct  atc ttt aaa ggt ttc  ctg gca ccg aat gac  ggc atg gca gag        3859
Ser  Ile Phe Lys Gly Phe  Leu Ala Pro Asn Asp  Gly Met Ala Glu            
1225                 1230                 1235                            

cag  gca att acc aag ctg  aaa ctg gaa ggc ttc  gat acc cag aaa        3904
Gln  Ala Ile Thr Lys Leu  Lys Leu Glu Gly Phe  Asp Thr Gln Lys            
1240                 1245                 1250                            

att  ttc gta acc ggt cag  gat tat aac gac aaa  gcg aaa act ttt        3949
Ile  Phe Val Thr Gly Gln  Asp Tyr Asn Asp Lys  Ala Lys Thr Phe            
1255                 1260                 1265                            

att  aaa gac ggc gac cag  aac atg acc att tat  aaa ccg gac aaa        3994
Ile  Lys Asp Gly Asp Gln  Asn Met Thr Ile Tyr  Lys Pro Asp Lys            
1270                 1275                 1280                            

gtt  ctg ggt aaa gtg gca  gtg gaa gtt ctg cgt  gtt ctg att gcg        4039
Val  Leu Gly Lys Val Ala  Val Glu Val Leu Arg  Val Leu Ile Ala            
1285                 1290                 1295                            

aaa  aaa aac aaa gcc agc  cga agc gaa gtt gaa  aac gag ctg aaa        4084
Lys  Lys Asn Lys Ala Ser  Arg Ser Glu Val Glu  Asn Glu Leu Lys            
1300                 1305                 1310                            

gcg  aaa ctg ccg aac atc  tcc ttc aag tat gat  aac cag acc tac        4129
Ala  Lys Leu Pro Asn Ile  Ser Phe Lys Tyr Asp  Asn Gln Thr Tyr            
1315                 1320                 1325                            

aag  gtg caa ggc aag aac  att aat act atc ctg  gtt tct ccg gtg        4174
Lys  Val Gln Gly Lys Asn  Ile Asn Thr Ile Leu  Val Ser Pro Val            
1330                 1335                 1340                            

att  gta acc aaa gcg aat  gtg gac aac cct ggg  gcg gcg aaa ccg        4219
Ile  Val Thr Lys Ala Asn  Val Asp Asn Pro Gly  Ala Ala Lys Pro            
1345                 1350                 1355                            

gag  gca gcg aaa ccg gtt  gcg gct aaa ccg gag  acc acc aaa ccg        4264
Glu  Ala Ala Lys Pro Val  Ala Ala Lys Pro Glu  Thr Thr Lys Pro            
1360                 1365                 1370                            

gtg  gct gct aaa ccg gaa  gcg gcc aaa ccg gaa  gct gcg aaa ccg        4309
Val  Ala Ala Lys Pro Glu  Ala Ala Lys Pro Glu  Ala Ala Lys Pro            
1375                 1380                 1385                            

gtg  gcg gcg aag ccg gag  gct gcc aaa ccg gta  gct gct aag ccg        4354
Val  Ala Ala Lys Pro Glu  Ala Ala Lys Pro Val  Ala Ala Lys Pro            
1390                 1395                 1400                            

gaa  gcg gct aag ccg gtg  gca gca aaa ccg gag  gcg gca aaa ccg        4399
Glu  Ala Ala Lys Pro Val  Ala Ala Lys Pro Glu  Ala Ala Lys Pro            
1405                 1410                 1415                            

gtg  gcc gcc aag ccg gaa  gct gcc aag ccg gtt  gca acc aac act        4444
Val  Ala Ala Lys Pro Glu  Ala Ala Lys Pro Val  Ala Thr Asn Thr            
1420                 1425                 1430                            

ggt  ttt tct ctg acc aac  aaa ccg aaa gaa gac  tac ttt ccg atg        4489
Gly  Phe Ser Leu Thr Asn  Lys Pro Lys Glu Asp  Tyr Phe Pro Met            
1435                 1440                 1445                            

acc  gaa ggc tcc agc aac  cag ggt aaa aag tcc  gaa ggt act ccg        4534
Thr  Glu Gly Ser Ser Asn  Gln Gly Lys Lys Ser  Glu Gly Thr Pro            
1450                 1455                 1460                            

aac  cag ggt aag aaa gcg  gag ggt gca ccg aac  cag ggc aaa aaa        4579
Asn  Gln Gly Lys Lys Ala  Glu Gly Ala Pro Asn  Gln Gly Lys Lys            
1465                 1470                 1475                            

gcg  gaa ggc acc ccg aac  caa ggt aaa aaa gca  gag ggt gcg ccg        4624
Ala  Glu Gly Thr Pro Asn  Gln Gly Lys Lys Ala  Glu Gly Ala Pro            
1480                 1485                 1490                            

agc  cag cag agc ccg acc  acc gaa taa gaattcgctt aagtcgaaca           4671
Ser  Gln Gln Ser Pro Thr  Thr Glu                                         
1495                 1500                                                 

gaaagtaatc gtattgtaca cggccgcata atcgaaatta atacgactca ctatagggag     4731

accacaacgg tttcccatct tagtatatta gttaagtata agaaggagat atacc atg      4789
                                                             Met          
                                                                          

ggt tct  gat aat gaa atc gtg  gcg ggt att atg cgc  gac cat att        4834
Gly Ser  Asp Asn Glu Ile Val  Ala Gly Ile Met Arg  Asp His Ile            
    1505                 1510                 1515                        

att aac  ctg ctt aag gaa ggt  aaa cgt att gac gac  cgc ggt ttc        4879
Ile Asn  Leu Leu Lys Glu Gly  Lys Arg Ile Asp Asp  Arg Gly Phe            
    1520                 1525                 1530                        

gaa gat  tac cgc ccg att gaa  att gag gta ggt gtt  att gaa aaa        4924
Glu Asp  Tyr Arg Pro Ile Glu  Ile Glu Val Gly Val  Ile Glu Lys            
    1535                 1540                 1545                        

gcg gag  ggt agc gcg ctg gtg  aaa ctg ggt agc act  cag gtt ctg        4969
Ala Glu  Gly Ser Ala Leu Val  Lys Leu Gly Ser Thr  Gln Val Leu            
    1550                 1555                 1560                        

gtg ggt  att aaa acc tct ctg  ggc gag ccg ttt ccg  gac acc ccg        5014
Val Gly  Ile Lys Thr Ser Leu  Gly Glu Pro Phe Pro  Asp Thr Pro            
    1565                 1570                 1575                        

aac atg  ggc gtg atg acc acc  aat gtt gaa ctt gtt  ccg ctg gcg        5059
Asn Met  Gly Val Met Thr Thr  Asn Val Glu Leu Val  Pro Leu Ala            
    1580                 1585                 1590                        

tct ccg  act ttc gaa ccg ggc  ccg ccg gac gag cgt  gct atc gaa        5104
Ser Pro  Thr Phe Glu Pro Gly  Pro Pro Asp Glu Arg  Ala Ile Glu            
    1595                 1600                 1605                        

ctg gca  cgt gtt att gac cgt  ggt att cgt gag tcc  aaa gca ctg        5149
Leu Ala  Arg Val Ile Asp Arg  Gly Ile Arg Glu Ser  Lys Ala Leu            
    1610                 1615                 1620                        

aat ctg  gaa aaa atg gtt atc  gtg ccg ggc aaa att  gtt cgc gta        5194
Asn Leu  Glu Lys Met Val Ile  Val Pro Gly Lys Ile  Val Arg Val            
    1625                 1630                 1635                        

gtt ttt  atc gac gtt cac gtt  ctt gac cac gac ggt  aac ctg atg        5239
Val Phe  Ile Asp Val His Val  Leu Asp His Asp Gly  Asn Leu Met            
    1640                 1645                 1650                        

gac gcc  atc ggt att gca gct  atc gcc gca ctg ctg  aac gca cgt        5284
Asp Ala  Ile Gly Ile Ala Ala  Ile Ala Ala Leu Leu  Asn Ala Arg            
    1655                 1660                 1665                        

gtt ccg  aaa gtt cgc tac aac  gaa gaa acg ggt gaa  gtt gaa acc        5329
Val Pro  Lys Val Arg Tyr Asn  Glu Glu Thr Gly Glu  Val Glu Thr            
    1670                 1675                 1680                        

ctg gat  gaa act gaa ccg ctg  ccg gtt gaa aag att  ccg gtt ccg        5374
Leu Asp  Glu Thr Glu Pro Leu  Pro Val Glu Lys Ile  Pro Val Pro            
    1685                 1690                 1695                        

gtt act  ttc gct aaa att ggt  aat atc ctg gta gtt  gac ccg agc        5419
Val Thr  Phe Ala Lys Ile Gly  Asn Ile Leu Val Val  Asp Pro Ser            
    1700                 1705                 1710                        

ctg gat  gaa gag ctc gtg atg  gac ggc aaa att acc  att acc act        5464
Leu Asp  Glu Glu Leu Val Met  Asp Gly Lys Ile Thr  Ile Thr Thr            
    1715                 1720                 1725                        

gac gaa  acc ggc cat att tct  gcc gtt cag aaa tct  gaa ggt ggc        5509
Asp Glu  Thr Gly His Ile Ser  Ala Val Gln Lys Ser  Glu Gly Gly            
    1730                 1735                 1740                        

gct ttc  aaa ctg gaa gaa gta  atg tac gcg gtg gaa  act gca ttc        5554
Ala Phe  Lys Leu Glu Glu Val  Met Tyr Ala Val Glu  Thr Ala Phe            
    1745                 1750                 1755                        

aag aag  gcg gaa gaa atc cgt  aaa ctg att ctg gaa  gct gtt gag        5599
Lys Lys  Ala Glu Glu Ile Arg  Lys Leu Ile Leu Glu  Ala Val Glu            
    1760                 1765                 1770                        

aag gcc  aaa cag ctc gag ggc  cag aag aag gcg gta  cgt aag gaa        5644
Lys Ala  Lys Gln Leu Glu Gly  Gln Lys Lys Ala Val  Arg Lys Glu            
    1775                 1780                 1785                        

gag gaa  ctg gaa acc tac aac  ccg aaa gac gag ttt  aat atc ctg        5689
Glu Glu  Leu Glu Thr Tyr Asn  Pro Lys Asp Glu Phe  Asn Ile Leu            
    1790                 1795                 1800                        

aac ccg  ggt gaa att tct gac  gtg ctg ctg ctg gac  gta acc ccg        5734
Asn Pro  Gly Glu Ile Ser Asp  Val Leu Leu Leu Asp  Val Thr Pro            
    1805                 1810                 1815                        

ctg acc  ctg ggc att gag act  ctg ggt ggc att gct  acc ccg ctg        5779
Leu Thr  Leu Gly Ile Glu Thr  Leu Gly Gly Ile Ala  Thr Pro Leu            
    1820                 1825                 1830                        

att ccg  cga aac acc acc att  cca gtg acc aaa agc  caa att ttc        5824
Ile Pro  Arg Asn Thr Thr Ile  Pro Val Thr Lys Ser  Gln Ile Phe            
    1835                 1840                 1845                        

tcc acc  gct gaa gat aac cag  acc gaa gtt acc atc  tcc gtt gtg        5869
Ser Thr  Ala Glu Asp Asn Gln  Thr Glu Val Thr Ile  Ser Val Val            
    1850                 1855                 1860                        

caa ggt  gaa cga cag ctg gca  gcc gac aac aag atg  ctg ggt cgc        5914
Gln Gly  Glu Arg Gln Leu Ala  Ala Asp Asn Lys Met  Leu Gly Arg            
    1865                 1870                 1875                        

ttt aac  ctg agc ggc atc gaa  gcg gct ccg cgt ggt  ctg cca caa        5959
Phe Asn  Leu Ser Gly Ile Glu  Ala Ala Pro Arg Gly  Leu Pro Gln            
    1880                 1885                 1890                        

att gaa  gtg tcc ttc agc atc  gat gta aac ggc atc  acc act gtt        6004
Ile Glu  Val Ser Phe Ser Ile  Asp Val Asn Gly Ile  Thr Thr Val            
    1895                 1900                 1905                        

tcc gct  aaa gac aaa aaa acc  ggt aaa gaa cag acc  att acc atc        6049
Ser Ala  Lys Asp Lys Lys Thr  Gly Lys Glu Gln Thr  Ile Thr Ile            
    1910                 1915                 1920                        

aag aat  acc tcc acc ctg tct  gaa gaa gaa att aac  aaa atg att        6094
Lys Asn  Thr Ser Thr Leu Ser  Glu Glu Glu Ile Asn  Lys Met Ile            
    1925                 1930                 1935                        

cag gaa  gct gag gaa aac cgt  gaa gcc gat gca ctg  aaa aaa gac        6139
Gln Glu  Ala Glu Glu Asn Arg  Glu Ala Asp Ala Leu  Lys Lys Asp            
    1940                 1945                 1950                        

aaa att  gaa acc acc gta cgt  gcg gaa ggc ctg att  aac cag ctg        6184
Lys Ile  Glu Thr Thr Val Arg  Ala Glu Gly Leu Ile  Asn Gln Leu            
    1955                 1960                 1965                        

gaa aaa  tct att act gac cag  ggt gag aaa att gac  ccg aaa cag        6229
Glu Lys  Ser Ile Thr Asp Gln  Gly Glu Lys Ile Asp  Pro Lys Gln            
    1970                 1975                 1980                        

aaa gaa  ctg ctg gaa aag cag  att cag gaa ctg aaa  gac ctg ctg        6274
Lys Glu  Leu Leu Glu Lys Gln  Ile Gln Glu Leu Lys  Asp Leu Leu            
    1985                 1990                 1995                        

aaa gag  gat aaa acc gac gaa  ctg aaa ctg aaa ctg  gac cag att        6319
Lys Glu  Asp Lys Thr Asp Glu  Leu Lys Leu Lys Leu  Asp Gln Ile            
    2000                 2005                 2010                        

gaa gct  gcg gcc caa tcc ttc  gcg cag gca acc gcg  cag caa gcg        6364
Glu Ala  Ala Ala Gln Ser Phe  Ala Gln Ala Thr Ala  Gln Gln Ala            
    2015                 2020                 2025                        

aac acc  agc gaa tct gac ccg  aaa gcg gac gat agc  aac acc atc        6409
Asn Thr  Ser Glu Ser Asp Pro  Lys Ala Asp Asp Ser  Asn Thr Ile            
    2030                 2035                 2040                        

gac gcg  gag att aaa caa gat  ggt tcc ggg aaa cag  gat gaa atc        6454
Asp Ala  Glu Ile Lys Gln Asp  Gly Ser Gly Lys Gln  Asp Glu Ile            
    2045                 2050                 2055                        

aaa aaa  ttc acc ttc gac ctg  ctg tac aaa ctg att  gaa ctg gaa        6499
Lys Lys  Phe Thr Phe Asp Leu  Leu Tyr Lys Leu Ile  Glu Leu Glu            
    2060                 2065                 2070                        

aaa gat  tac ctg tac gac ctg  tac tcc gaa gtg ggc  ctg gcg gaa        6544
Lys Asp  Tyr Leu Tyr Asp Leu  Tyr Ser Glu Val Gly  Leu Ala Glu            
    2075                 2080                 2085                        

agc gcc  atc aag ttc agc atc  tac aac gct ggc aaa  ttc ctg caa        6589
Ser Ala  Ile Lys Phe Ser Ile  Tyr Asn Ala Gly Lys  Phe Leu Gln            
    2090                 2095                 2100                        

aac ctg  ggc tac gat tct ccg  ttt tct aaa gaa gag  acc gaa atc        6634
Asn Leu  Gly Tyr Asp Ser Pro  Phe Ser Lys Glu Glu  Thr Glu Ile            
    2105                 2110                 2115                        

gag ccg  gag att ttc tcc cag  ctg agc gct cgc gca  gat gag aac        6679
Glu Pro  Glu Ile Phe Ser Gln  Leu Ser Ala Arg Ala  Asp Glu Asn            
    2120                 2125                 2130                        

cat gac  ttc ttc tct ggt aac  ggc agc agc tac gtg  atg gcg ctg        6724
His Asp  Phe Phe Ser Gly Asn  Gly Ser Ser Tyr Val  Met Ala Leu            
    2135                 2140                 2145                        

gca gag  gaa acc gaa gac gaa  gat tgg gag ttc taa gctt                6764
Ala Glu  Glu Thr Glu Asp Glu  Asp Trp Glu Phe                             
    2150                 2155                                             


<210>  26
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Ala Lys Arg Ile Phe Val Gln Asn Arg Glu Leu Val Val Pro Gly 
1               5                   10                  15      


Thr Leu Leu Ala Gln Gly Pro Tyr Lys Asn Gly Arg Gly Thr Phe Arg 
            20                  25                  30          


Glu Gly Ser Arg Ile Tyr Ser Thr Val Ile Gly Leu Val Asp Ile Lys 
        35                  40                  45              


Gly Asn Thr Ile Arg Val Ile Pro Leu Glu Gly Pro Tyr Ile Pro Glu 
    50                  55                  60                  


Val Gly Asp Asn Val Ile Gly Lys Ile Val Asp Val Lys Phe Ser Ser 
65                  70                  75                  80  


Trp Val Val Asp Ile Gly Ala Pro Tyr Pro Ala Asn Leu Lys Ile Gln 
                85                  90                  95      


Asp Phe Thr Asp Glu Lys Ile Asp Leu Leu Arg Thr Asp Leu Arg Lys 
            100                 105                 110         


Phe Phe Asp Ile Gly Asp Ile Ile Tyr Ala Lys Val Lys Ala Ile Thr 
        115                 120                 125             


Glu Val Asn Asn Ile Asp Leu Thr Thr Lys Gly Met Pro Phe Asn Gly 
    130                 135                 140                 


Gly Pro Leu Lys Gly Gly Gln Ile Val Lys Ile Thr Pro Ser Arg Val 
145                 150                 155                 160 


Pro Arg Val Ile Gly Arg Gly Gly Ser Met Ile Asn Met Ile Lys Lys 
                165                 170                 175     


Leu Thr Met Thr Arg Ile Ile Val Gly Gln Asn Gly Trp Ile Trp Val 
            180                 185                 190         


Ser Gly Lys Asn Asp Ala Leu Glu Lys Leu Ala Ile Glu Ala Ile Leu 
        195                 200                 205             


Lys Ile Asp Lys Glu Ser His Thr Arg Gly Leu Thr Asp Arg Ile Lys 
    210                 215                 220                 


Ala Leu Leu Leu Ser Arg Leu Gln Glu Leu Lys Glu Lys Gly Val Ile 
225                 230                 235                 240 


Glu Glu Ile Pro Lys Leu Glu Glu Glu Pro Gln Gly Glu Asp Glu Val 
                245                 250                 255     


Asn Gly Asn Asp Gly Glu Ala Arg Ser Gly Val Asn Asn Asp Pro Asn 
            260                 265                 270         


Tyr Lys Ile Glu Asp Leu Lys Val Ile Lys Asn Glu Ala Gly Asp His 
        275                 280                 285             


Gln Leu Gly Ser Lys Pro Ile Lys Ile Ala Leu Ile Gly Ala Gly Asn 
    290                 295                 300                 


Val Gly Asn Ser Phe Leu Tyr Ala Ala Met Asn Gln Gly Leu Ala Ser 
305                 310                 315                 320 


Glu Tyr Gly Ile Ile Asp Ile Asn Pro Asp Phe Ala Asp Gly Asn Ala 
                325                 330                 335     


Phe Asp Phe Glu Asp Ala Ser Ala Ser Leu Pro Phe Pro Ile Ser Val 
            340                 345                 350         


Ser Arg Tyr Glu Tyr Lys Asp Leu Lys Asp Ala Asp Phe Ile Val Ile 
        355                 360                 365             


Thr Ala Gly Arg Pro Gln Lys Pro Gly Glu Thr Arg Leu Glu Leu Val 
    370                 375                 380                 


Ala Asp Asn Ile Arg Ile Ile Arg Glu Ile Ala Leu Lys Val Lys Glu 
385                 390                 395                 400 


Ser Gly Phe Ser Gly Ile Ser Ile Ile Val Ala Asn Pro Val Asp Ile 
                405                 410                 415     


Ile Thr Arg Ala Tyr Arg Asp Ala Ser Gly Phe Ser Asp Gln Lys Val 
            420                 425                 430         


Ile Gly Ser Gly Thr Val Leu Asp Thr Ala Arg Leu Gln Phe Ala Ile 
        435                 440                 445             


Ala Lys Arg Ala Lys Val Ser Pro Asn Ser Val Gln Ala Tyr Val Met 
    450                 455                 460                 


Gly Glu His Gly Asp Ser Ser Phe Val Ala Tyr Ser Asn Ile Lys Ile 
465                 470                 475                 480 


Ala Gly Glu Tyr Phe Ser Ala Tyr Ser Lys Leu Thr Gly Ile Asp Ser 
                485                 490                 495     


Ser Asn Tyr Glu Lys Glu Leu Glu Tyr Pro Val Ser Arg Arg Ala Tyr 
            500                 505                 510         


Glu Ile Ile Asn Arg Lys Arg Ala Thr Phe Tyr Gly Ile Gly Ala Ala 
        515                 520                 525             


Ile Ala Lys Ile Val Ser Asn Ile Ile Lys Asp Thr Lys Asn Ile Met 
    530                 535                 540                 


Ile Ala Gly Ala Asn Leu Arg Gly Glu Tyr Gly Phe His Gly Val Asn 
545                 550                 555                 560 


Ile Gly Val Pro Val Val Leu Gly Ala Asn Gly Ile Glu Lys Ile Ile 
                565                 570                 575     


Glu Ile Ser Leu Asn Asp Lys Glu Lys Glu Lys Phe Ala Lys Ser Val 
            580                 585                 590         


Ala Ile Ile Asp Lys Ile Tyr Gln Asp Ala Ile Lys Asn Ile Pro Lys 
        595                 600                 605             


Ser Gln Lys Ser Glu Gly Thr Gln Asn Gln Gly Lys Lys Ala Glu Gly 
    610                 615                 620                 


Ala Pro Asn Gln Ser Lys Lys Ser Glu Glu Asn Ser Asn Lys Leu Thr 
625                 630                 635                 640 


Glu Tyr Ile Gln Glu Leu Gly Thr Lys Val Glu Lys Ser Leu Lys Ser 
                645                 650                 655     


Lys Gly Lys Asn Tyr Ser Ala Glu Val Glu Lys Ile Ile Glu Ala Phe 
            660                 665                 670         


Ser Gly Gly Tyr Lys Phe Leu Asp Phe Ala Leu Val Glu Gln Thr Pro 
        675                 680                 685             


Lys Pro Glu Thr Pro Lys Thr Glu Ala Ala Lys Pro Glu Thr Thr Lys 
    690                 695                 700                 


Pro Val Ala Ala Arg Pro Glu Ala Ala Lys Val Ala Ala Lys Pro Ser 
705                 710                 715                 720 


Ala Ala Lys Pro Val Ser Ser Pro Ala Pro Lys Lys Ser Thr Leu Tyr 
                725                 730                 735     


Val 
    


<210>  27
<211>  765
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Met Ala Glu Lys Pro Glu Gly Leu Lys Leu Ile Asp Glu Asn Gly Arg 
1               5                   10                  15      


Arg Ile Asp Gly Arg Lys Lys Tyr Glu Leu Arg Pro Ile Lys Met Glu 
            20                  25                  30          


Val Gly Val Leu Lys Asn Ala Asn Gly Ser Ala Tyr Ile Glu Trp Gly 
        35                  40                  45              


Lys Asn Lys Ile Ile Ala Ala Val Tyr Gly Pro Arg Glu Leu His Pro 
    50                  55                  60                  


Lys His Leu Gln Arg Pro Asp Arg Ala Ile Leu Arg Val Arg Tyr Asn 
65                  70                  75                  80  


Met Ala Pro Phe Ser Val Glu Glu Thr Lys Ser Pro Gly Pro Asp Arg 
                85                  90                  95      


Arg Ser Ile Glu Ile Ser Lys Val Ile Lys Gly Ala Leu Glu Pro Ala 
            100                 105                 110         


Leu Ile Leu Glu Met Phe Pro Arg Thr Ala Ile Asp Val Phe Ile Glu 
        115                 120                 125             


Val Leu Gln Ala Asp Ala Gly Thr Arg Val Ala Gly Ile Thr Ala Ala 
    130                 135                 140                 


Ser Leu Ala Leu Ala Asp Ala Gly Ile Pro Met Arg Asp Leu Val Ala 
145                 150                 155                 160 


Ala Cys Ala Ala Gly Lys Ile Glu Gly Glu Ile Val Leu Asp Leu Asn 
                165                 170                 175     


Lys Glu Glu Asp Asn Tyr Gly Glu Ala Asp Val Pro Val Ala Ile Met 
            180                 185                 190         


Pro Leu Lys Asn Asp Ile Thr Leu Leu Gln Met Asp Gly Tyr Leu Thr 
        195                 200                 205             


Lys Asp Glu Phe Ile Glu Ala Val Lys Leu Ala Ile Lys Gly Ala Lys 
    210                 215                 220                 


Ala Val Tyr Gln Lys Gln Arg Glu Ala Leu Lys Glu Lys Tyr Leu Lys 
225                 230                 235                 240 


Ile Ala Gln Glu Val Glu Gly Ser Pro Lys His Lys Val Ser Asn Asp 
                245                 250                 255     


Ser Ile Arg Ile Ala Leu Thr Asp Pro Asp Asn Pro Arg Trp Ile Ser 
            260                 265                 270         


Ala Gln Lys Asp Ile Ile Ser Tyr Val Asp Glu Thr Glu Ala Ala Thr 
        275                 280                 285             


Ser Thr Ile Thr Lys Asn Gln Asp Ala Gln Asn Asn Trp Leu Thr Gln 
    290                 295                 300                 


Gln Ala Asn Leu Ser Pro Ala Pro Lys Gly Phe Ile Ile Ala Pro Glu 
305                 310                 315                 320 


Asn Gly Ser Gly Val Gly Thr Ala Val Asn Thr Ile Ala Asp Lys Gly 
                325                 330                 335     


Ile Pro Ile Val Ala Tyr Asp Arg Leu Ile Thr Gly Ser Asp Lys Tyr 
            340                 345                 350         


Asp Trp Tyr Val Ser Phe Asp Asn Glu Lys Val Gly Glu Leu Gln Gly 
        355                 360                 365             


Leu Ser Leu Ala Ala Gly Leu Leu Gly Lys Glu Asp Gly Ala Phe Asp 
    370                 375                 380                 


Ser Ile Asp Gln Met Asn Glu Tyr Leu Lys Ser His Met Pro Gln Glu 
385                 390                 395                 400 


Thr Ile Ser Phe Tyr Thr Ile Ala Gly Ser Gln Asp Asp Asn Asn Ser 
                405                 410                 415     


Gln Tyr Phe Tyr Asn Gly Ala Met Lys Val Leu Lys Glu Leu Met Lys 
            420                 425                 430         


Asn Ser Gln Asn Lys Ile Ile Asp Leu Ser Pro Glu Gly Glu Asn Ala 
        435                 440                 445             


Val Tyr Val Pro Gly Trp Asn Tyr Gly Thr Ala Gly Gln Arg Ile Gln 
    450                 455                 460                 


Ser Phe Leu Thr Ile Asn Lys Asp Pro Ala Gly Gly Asn Lys Ile Lys 
465                 470                 475                 480 


Ala Val Gly Ser Lys Pro Ala Ser Ile Phe Lys Gly Phe Leu Ala Pro 
                485                 490                 495     


Asn Asp Gly Met Ala Glu Gln Ala Ile Thr Lys Leu Lys Leu Glu Gly 
            500                 505                 510         


Phe Asp Thr Gln Lys Ile Phe Val Thr Gly Gln Asp Tyr Asn Asp Lys 
        515                 520                 525             


Ala Lys Thr Phe Ile Lys Asp Gly Asp Gln Asn Met Thr Ile Tyr Lys 
    530                 535                 540                 


Pro Asp Lys Val Leu Gly Lys Val Ala Val Glu Val Leu Arg Val Leu 
545                 550                 555                 560 


Ile Ala Lys Lys Asn Lys Ala Ser Arg Ser Glu Val Glu Asn Glu Leu 
                565                 570                 575     


Lys Ala Lys Leu Pro Asn Ile Ser Phe Lys Tyr Asp Asn Gln Thr Tyr 
            580                 585                 590         


Lys Val Gln Gly Lys Asn Ile Asn Thr Ile Leu Val Ser Pro Val Ile 
        595                 600                 605             


Val Thr Lys Ala Asn Val Asp Asn Pro Gly Ala Ala Lys Pro Glu Ala 
    610                 615                 620                 


Ala Lys Pro Val Ala Ala Lys Pro Glu Thr Thr Lys Pro Val Ala Ala 
625                 630                 635                 640 


Lys Pro Glu Ala Ala Lys Pro Glu Ala Ala Lys Pro Val Ala Ala Lys 
                645                 650                 655     


Pro Glu Ala Ala Lys Pro Val Ala Ala Lys Pro Glu Ala Ala Lys Pro 
            660                 665                 670         


Val Ala Ala Lys Pro Glu Ala Ala Lys Pro Val Ala Ala Lys Pro Glu 
        675                 680                 685             


Ala Ala Lys Pro Val Ala Thr Asn Thr Gly Phe Ser Leu Thr Asn Lys 
    690                 695                 700                 


Pro Lys Glu Asp Tyr Phe Pro Met Thr Glu Gly Ser Ser Asn Gln Gly 
705                 710                 715                 720 


Lys Lys Ser Glu Gly Thr Pro Asn Gln Gly Lys Lys Ala Glu Gly Ala 
                725                 730                 735     


Pro Asn Gln Gly Lys Lys Ala Glu Gly Thr Pro Asn Gln Gly Lys Lys 
            740                 745                 750         


Ala Glu Gly Ala Pro Ser Gln Gln Ser Pro Thr Thr Glu 
        755                 760                 765 


<210>  28
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Gly Ser Asp Asn Glu Ile Val Ala Gly Ile Met Arg Asp His Ile 
1               5                   10                  15      


Ile Asn Leu Leu Lys Glu Gly Lys Arg Ile Asp Asp Arg Gly Phe Glu 
            20                  25                  30          


Asp Tyr Arg Pro Ile Glu Ile Glu Val Gly Val Ile Glu Lys Ala Glu 
        35                  40                  45              


Gly Ser Ala Leu Val Lys Leu Gly Ser Thr Gln Val Leu Val Gly Ile 
    50                  55                  60                  


Lys Thr Ser Leu Gly Glu Pro Phe Pro Asp Thr Pro Asn Met Gly Val 
65                  70                  75                  80  


Met Thr Thr Asn Val Glu Leu Val Pro Leu Ala Ser Pro Thr Phe Glu 
                85                  90                  95      


Pro Gly Pro Pro Asp Glu Arg Ala Ile Glu Leu Ala Arg Val Ile Asp 
            100                 105                 110         


Arg Gly Ile Arg Glu Ser Lys Ala Leu Asn Leu Glu Lys Met Val Ile 
        115                 120                 125             


Val Pro Gly Lys Ile Val Arg Val Val Phe Ile Asp Val His Val Leu 
    130                 135                 140                 


Asp His Asp Gly Asn Leu Met Asp Ala Ile Gly Ile Ala Ala Ile Ala 
145                 150                 155                 160 


Ala Leu Leu Asn Ala Arg Val Pro Lys Val Arg Tyr Asn Glu Glu Thr 
                165                 170                 175     


Gly Glu Val Glu Thr Leu Asp Glu Thr Glu Pro Leu Pro Val Glu Lys 
            180                 185                 190         


Ile Pro Val Pro Val Thr Phe Ala Lys Ile Gly Asn Ile Leu Val Val 
        195                 200                 205             


Asp Pro Ser Leu Asp Glu Glu Leu Val Met Asp Gly Lys Ile Thr Ile 
    210                 215                 220                 


Thr Thr Asp Glu Thr Gly His Ile Ser Ala Val Gln Lys Ser Glu Gly 
225                 230                 235                 240 


Gly Ala Phe Lys Leu Glu Glu Val Met Tyr Ala Val Glu Thr Ala Phe 
                245                 250                 255     


Lys Lys Ala Glu Glu Ile Arg Lys Leu Ile Leu Glu Ala Val Glu Lys 
            260                 265                 270         


Ala Lys Gln Leu Glu Gly Gln Lys Lys Ala Val Arg Lys Glu Glu Glu 
        275                 280                 285             


Leu Glu Thr Tyr Asn Pro Lys Asp Glu Phe Asn Ile Leu Asn Pro Gly 
    290                 295                 300                 


Glu Ile Ser Asp Val Leu Leu Leu Asp Val Thr Pro Leu Thr Leu Gly 
305                 310                 315                 320 


Ile Glu Thr Leu Gly Gly Ile Ala Thr Pro Leu Ile Pro Arg Asn Thr 
                325                 330                 335     


Thr Ile Pro Val Thr Lys Ser Gln Ile Phe Ser Thr Ala Glu Asp Asn 
            340                 345                 350         


Gln Thr Glu Val Thr Ile Ser Val Val Gln Gly Glu Arg Gln Leu Ala 
        355                 360                 365             


Ala Asp Asn Lys Met Leu Gly Arg Phe Asn Leu Ser Gly Ile Glu Ala 
    370                 375                 380                 


Ala Pro Arg Gly Leu Pro Gln Ile Glu Val Ser Phe Ser Ile Asp Val 
385                 390                 395                 400 


Asn Gly Ile Thr Thr Val Ser Ala Lys Asp Lys Lys Thr Gly Lys Glu 
                405                 410                 415     


Gln Thr Ile Thr Ile Lys Asn Thr Ser Thr Leu Ser Glu Glu Glu Ile 
            420                 425                 430         


Asn Lys Met Ile Gln Glu Ala Glu Glu Asn Arg Glu Ala Asp Ala Leu 
        435                 440                 445             


Lys Lys Asp Lys Ile Glu Thr Thr Val Arg Ala Glu Gly Leu Ile Asn 
    450                 455                 460                 


Gln Leu Glu Lys Ser Ile Thr Asp Gln Gly Glu Lys Ile Asp Pro Lys 
465                 470                 475                 480 


Gln Lys Glu Leu Leu Glu Lys Gln Ile Gln Glu Leu Lys Asp Leu Leu 
                485                 490                 495     


Lys Glu Asp Lys Thr Asp Glu Leu Lys Leu Lys Leu Asp Gln Ile Glu 
            500                 505                 510         


Ala Ala Ala Gln Ser Phe Ala Gln Ala Thr Ala Gln Gln Ala Asn Thr 
        515                 520                 525             


Ser Glu Ser Asp Pro Lys Ala Asp Asp Ser Asn Thr Ile Asp Ala Glu 
    530                 535                 540                 


Ile Lys Gln Asp Gly Ser Gly Lys Gln Asp Glu Ile Lys Lys Phe Thr 
545                 550                 555                 560 


Phe Asp Leu Leu Tyr Lys Leu Ile Glu Leu Glu Lys Asp Tyr Leu Tyr 
                565                 570                 575     


Asp Leu Tyr Ser Glu Val Gly Leu Ala Glu Ser Ala Ile Lys Phe Ser 
            580                 585                 590         


Ile Tyr Asn Ala Gly Lys Phe Leu Gln Asn Leu Gly Tyr Asp Ser Pro 
        595                 600                 605             


Phe Ser Lys Glu Glu Thr Glu Ile Glu Pro Glu Ile Phe Ser Gln Leu 
    610                 615                 620                 


Ser Ala Arg Ala Asp Glu Asn His Asp Phe Phe Ser Gly Asn Gly Ser 
625                 630                 635                 640 


Ser Tyr Val Met Ala Leu Ala Glu Glu Thr Glu Asp Glu Asp Trp Glu 
                645                 650                 655     


Phe 
    


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer inverso para sequenciamento de insertos em vetor T7

<400>  29
tgtggtctcc ctatagtgag tcg                                               23


<210>  30
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer inverso para amplificacao do antigeno P36

<400>  30
ggctgcagtt aaatgttttt aatcgcatcc tg                                     32


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer forward para amplificacao do antigeno MHP271

<400>  31
ccagatctcc gaaatcccaa aaatctg                                           27


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer forward para amplificacao da proteina Rrp41

<400>  32
agcatatggc agagaaaccg gaagg                                             25


<210>  33
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer inverso para amplificacao do antigeno P46

<400>  33
ccgaattctt aagggttgtc cacattcgct ttgg                                   34


<210>  34
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer forward para amplificacao do antigeno P97R1R2

<400>  34
aaggatccgc gaaaccggag gcagcgaaac c                                      31


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer inverso para amplificacao do antigeno HSP

<400>  35
ccaagcttaa tcttgtttaa tctccgcgtc g                                      31


<210>  36
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer forward para amplificacao do antigeno NrdF

<400>  36
ggctcgaggg gaaacaggat gaaatcaaaa aattcac                                37


