                               SEQUENCE LISTING	

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> INTERPENETRATING NETWORK HYDROGELS WITH INDEPENDENTLY TUNABLE STIFFNESS

<130> 117823-09420

<140>
<141>

<150> 62/011,517
<151> 2014-06-12

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 1629
<212> DNA
<213> Homo sapiens

<400> 1
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210> 2
<211> 178
<212> PRT
<213> Homo sapiens

<400> 2
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 3
<211> 4507
<212> DNA
<213> Homo sapiens

<400> 3
gaccaattgt catacgactt gcagtgagcg tcaggagcac gtccaggaac tcctcagcag       60

cgcctccttc agctccacag ccagacgccc tcagacagca aagcctaccc ccgcgccgcg      120

ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct gtgcgcggtc ctggcgctca      180

gccatacagc aaatccttgc tgttcccacc catgtcaaaa ccgaggtgta tgtatgagtg      240

tgggatttga ccagtataag tgcgattgta cccggacagg attctatgga gaaaactgct      300

caacaccgga atttttgaca agaataaaat tatttctgaa acccactcca aacacagtgc      360

actacatact tacccacttc aagggatttt ggaacgttgt gaataacatt cccttccttc      420

gaaatgcaat tatgagttat gtgttgacat ccagatcaca tttgattgac agtccaccaa      480

cttacaatgc tgactatggc tacaaaagct gggaagcctt ctctaacctc tcctattata      540

ctagagccct tcctcctgtg cctgatgatt gcccgactcc cttgggtgtc aaaggtaaaa      600

agcagcttcc tgattcaaat gagattgtgg aaaaattgct tctaagaaga aagttcatcc      660

ctgatcccca gggctcaaac atgatgtttg cattctttgc ccagcacttc acgcatcagt      720

ttttcaagac agatcataag cgagggccag ctttcaccaa cgggctgggc catggggtgg      780

acttaaatca tatttacggt gaaactctgg ctagacagcg taaactgcgc cttttcaagg      840

atggaaaaat gaaatatcag ataattgatg gagagatgta tcctcccaca gtcaaagata      900

ctcaggcaga gatgatctac cctcctcaag tccctgagca tctacggttt gctgtggggc      960

aggaggtctt tggtctggtg cctggtctga tgatgtatgc cacaatctgg ctgcgggaac     1020

acaacagagt atgcgatgtg cttaaacagg agcatcctga atggggtgat gagcagttgt     1080

tccagacaag caggctaata ctgataggag agactattaa gattgtgatt gaagattatg     1140

tgcaacactt gagtggctat cacttcaaac tgaaatttga cccagaacta cttttcaaca     1200

aacaattcca gtaccaaaat cgtattgctg ctgaatttaa caccctctat cactggcatc     1260

cccttctgcc tgacaccttt caaattcatg accagaaata caactatcaa cagtttatct     1320

acaacaactc tatattgctg gaacatggaa ttacccagtt tgttgaatca ttcaccaggc     1380

aaattgctgg cagggttgct ggtggtagga atgttccacc cgcagtacag aaagtatcac     1440

aggcttccat tgaccagagc aggcagatga aataccagtc ttttaatgag taccgcaaac     1500

gctttatgct gaagccctat gaatcatttg aagaacttac aggagaaaag gaaatgtctg     1560

cagagttgga agcactctat ggtgacatcg atgctgtgga gctgtatcct gcccttctgg     1620

tagaaaagcc tcggccagat gccatctttg gtgaaaccat ggtagaagtt ggagcaccat     1680

tctccttgaa aggacttatg ggtaatgtta tatgttctcc tgcctactgg aagccaagca     1740

cttttggtgg agaagtgggt tttcaaatca tcaacactgc ctcaattcag tctctcatct     1800

gcaataacgt gaagggctgt ccctttactt cattcagtgt tccagatcca gagctcatta     1860

aaacagtcac catcaatgca agttcttccc gctccggact agatgatatc aatcccacag     1920

tactactaaa agaacgttcg actgaactgt agaagtctaa tgatcatatt tatttattta     1980

tatgaaccat gtctattaat ttaattattt aataatattt atattaaact ccttatgtta     2040

cttaacatct tctgtaacag aagtcagtac tcctgttgcg gagaaaggag tcatacttgt     2100

gaagactttt atgtcactac tctaaagatt ttgctgttgc tgttaagttt ggaaaacagt     2160

ttttattctg ttttataaac cagagagaaa tgagttttga cgtcttttta cttgaatttc     2220

aacttatatt ataagaacga aagtaaagat gtttgaatac ttaaacactg tcacaagatg     2280

gcaaaatgct gaaagttttt acactgtcga tgtttccaat gcatcttcca tgatgcatta     2340

gaagtaacta atgtttgaaa ttttaaagta cttttggtta tttttctgtc atcaaacaaa     2400

aacaggtatc agtgcattat taaatgaata tttaaattag acattaccag taatttcatg     2460

tctacttttt aaaatcagca atgaaacaat aatttgaaat ttctaaattc atagggtaga     2520

atcacctgta aaagcttgtt tgatttctta aagttattaa acttgtacat ataccaaaaa     2580

gaagctgtct tggatttaaa tctgtaaaat cagtagaaat tttactacaa ttgcttgtta     2640

aaatatttta taagtgatgt tcctttttca ccaagagtat aaaccttttt agtgtgactg     2700

ttaaaacttc cttttaaatc aaaatgccaa atttattaag gtggtggagc cactgcagtg     2760

ttatcttaaa ataagaatat tttgttgaga tattccagaa tttgtttata tggctggtaa     2820

catgtaaaat ctatatcagc aaaagggtct acctttaaaa taagcaataa caaagaagaa     2880

aaccaaatta ttgttcaaat ttaggtttaa acttttgaag caaacttttt tttatccttg     2940

tgcactgcag gcctggtact cagattttgc tatgaggtta atgaagtacc aagctgtgct     3000

tgaataatga tatgttttct cagattttct gttgtacagt ttaatttagc agtccatatc     3060

acattgcaaa agtagcaatg acctcataaa atacctcttc aaaatgctta aattcatttc     3120

acacattaat tttatctcag tcttgaagcc aattcagtag gtgcattgga atcaagcctg     3180

gctacctgca tgctgttcct tttcttttct tcttttagcc attttgctaa gagacacagt     3240

cttctcatca cttcgtttct cctattttgt tttactagtt ttaagatcag agttcacttt     3300

ctttggactc tgcctatatt ttcttacctg aacttttgca agttttcagg taaacctcag     3360

ctcaggactg ctatttagct cctcttaaga agattaaaag agaaaaaaaa aggccctttt     3420

aaaaatagta tacacttatt ttaagtgaaa agcagagaat tttatttata gctaatttta     3480

gctatctgta accaagatgg atgcaaagag gctagtgcct cagagagaac tgtacggggt     3540

ttgtgactgg aaaaagttac gttcccattc taattaatgc cctttcttat ttaaaaacaa     3600

aaccaaatga tatctaagta gttctcagca ataataataa tgacgataat acttcttttc     3660

cacatctcat tgtcactgac atttaatggt actgtatatt acttaattta ttgaagatta     3720

ttatttatgt cttattagga cactatggtt ataaactgtg tttaagccta caatcattga     3780

tttttttttg ttatgtcaca atcagtatat tttctttggg gttacctctc tgaatattat     3840

gtaaacaatc caaagaaatg attgtattaa gatttgtgaa taaattttta gaaatctgat     3900

tggcatattg agatatttaa ggttgaatgt ttgtccttag gataggccta tgtgctagcc     3960

cacaaagaat attgtctcat tagcctgaat gtgccataag actgaccttt taaaatgttt     4020

tgagggatct gtggatgctt cgttaatttg ttcagccaca atttattgag aaaatattct     4080

gtgtcaagca ctgtgggttt taatattttt aaatcaaacg ctgattacag ataatagtat     4140

ttatataaat aattgaaaaa aattttcttt tgggaagagg gagaaaatga aataaatatc     4200

attaaagata actcaggaga atcttcttta caattttacg tttagaatgt ttaaggttaa     4260

gaaagaaata gtcaatatgc ttgtataaaa cactgttcac tgtttttttt aaaaaaaaaa     4320

cttgatttgt tattaacatt gatctgctga caaaacctgg gaatttgggt tgtgtatgcg     4380

aatgtttcag tgcctcagac aaatgtgtat ttaacttatg taaaagataa gtctggaaat     4440

aaatgtctgt ttatttttgt actatttaaa aattgacaga tcttttctga agaaaaaaaa     4500

aaaaaaa                                                               4507


<210> 4
<211> 604
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210> 5
<211> 6082
<212> DNA
<213> Homo sapiens

<400> 5
ataacgtctt tgtcactaaa atgttcccca ggggccttcg gcgagtcttt ttgtttggtt       60

ttttgttttt aatctgtggc tcttgataat ttatctagtg gttgcctaca cctgaaaaac      120

aagacacagt gtttaactat caacgaaaga actggacggc tccccgccgc agtcccactc      180

cccgagtttg tggctggcat ttgggccacg ccgggctggg cggtcacagc gaggggcgcg      240

cagtttgggg tcacacagct ccgcttctag gccccaacca ccgttaaaag gggaagcccg      300

tgccccatca ggtccgctct tgctgagccc agagccatcc cgcgctctgc gggctgggag      360

gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc cagcgccccc tgcagccgcg      420

cgtaggcaga gacggagccc ggccctgcgc ctccgcacca cgcccgggac cccacccagc      480

ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc cggctggcgg cagaaaccgg      540

gagtggggcc gggcgagtgc gcggcatccc aggccggccc gaacgctccg cccgcggtgg      600

gccgacttcc cctcctcttc cctctctcct tcctttagcc cgctggcgcc ggacacgctg      660

cgcctcatct cttggggcgt tcttccccgt tggccaaccg tcgcatcccg tgcaactttg      720

gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag cgcatggctt gggaagcgag      780

gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg gtgatgctgt tgctgtgcct      840

gggggtcccg accggccgcc cctacaacgt ggacactgag agcgcgctgc tttaccaggg      900

cccccacaac acgctgttcg gctactcggt cgtgctgcac agccacgggg cgaaccgatg      960

gctcctagtg ggtgcgccca ctgccaactg gctcgccaac gcttcagtga tcaatcccgg     1020

ggcgatttac agatgcagga tcggaaagaa tcccggccag acgtgcgaac agctccagct     1080

gggtagccct aatggagaac cttgtggaaa gacttgtttg gaagagagag acaatcagtg     1140

gttgggggtc acactttcca gacagccagg agaaaatgga tccatcgtga cttgtgggca     1200

tagatggaaa aatatatttt acataaagaa tgaaaataag ctccccactg gtggttgcta     1260

tggagtgccc cctgatttac gaacagaact gagtaaaaga atagctccgt gttatcaaga     1320

ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa gctggaatat ccagttttta     1380

cacaaaggat ttaattgtga tgggggcccc aggatcatct tactggactg gctctctttt     1440

tgtctacaat ataactacaa ataaatacaa ggctttttta gacaaacaaa atcaagtaaa     1500

atttggaagt tatttaggat attcagtcgg agctggtcat tttcggagcc agcatactac     1560

cgaagtagtc ggaggagctc ctcaacatga gcagattggt aaggcatata tattcagcat     1620

tgatgaaaaa gaactaaata tcttacatga aatgaaaggt aaaaagcttg gatcgtactt     1680

tggagcttct gtctgtgctg tggacctcaa tgcagatggc ttctcagatc tgctcgtggg     1740

agcacccatg cagagcacca tcagagagga aggaagagtg tttgtgtaca tcaactctgg     1800

ctcgggagca gtaatgaatg caatggaaac aaacctcgtt ggaagtgaca aatatgctgc     1860

aagatttggg gaatctatag ttaatcttgg cgacattgac aatgatggct ttgaagatgt     1920

tgctatcgga gctccacaag aagatgactt gcaaggtgct atttatattt acaatggccg     1980

tgcagatggg atctcgtcaa ccttctcaca gagaattgaa ggacttcaga tcagcaaatc     2040

gttaagtatg tttggacagt ctatatcagg acaaattgat gcagataata atggctatgt     2100

agatgtagca gttggtgctt ttcggtctga ttctgctgtc ttgctaagga caagacctgt     2160

agtaattgtt gacgcttctt taagccaccc tgagtcagta aatagaacga aatttgactg     2220

tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca ctttgtttct catataaggg     2280

caaggaagtt ccaggttaca ttgttttgtt ttataacatg agtttggatg tgaacagaaa     2340

ggcagagtct ccaccaagat tctatttctc ttctaatgga acttctgacg tgattacagg     2400

aagcatacag gtgtccagca gagaagctaa ctgtagaaca catcaagcat ttatgcggaa     2460

agatgtgcgg gacatcctca ccccaattca gattgaagct gcttaccacc ttggtcctca     2520

tgtcatcagt aaacgaagta cagaggaatt cccaccactt cagccaattc ttcagcagaa     2580

gaaagaaaaa gacataatga aaaaaacaat aaactttgca aggttttgtg cccatgaaaa     2640

ttgttctgct gatttacagg tttctgcaaa gattgggttt ttgaagcccc atgaaaataa     2700

aacatatctt gctgttggga gtatgaagac attgatgttg aatgtgtcct tgtttaatgc     2760

tggagatgat gcatatgaaa cgactctaca tgtcaaacta cccgtgggtc tttatttcat     2820

taagatttta gagctggaag agaagcaaat aaactgtgaa gtcacagata actctggcgt     2880

ggtacaactt gactgcagta ttggctatat atatgtagat catctctcaa ggatagatat     2940

tagctttctc ctggatgtga gctcactcag cagagcggaa gaggacctca gtatcacagt     3000

gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta aagcacagca gagtgactgt     3060

agcaatacct ttaaaatatg aggttaagct gactgttcat gggtttgtaa acccaacttc     3120

atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg tgcatggtgg agaaaatgaa     3180

cttaactttc catgttatca acactggcaa tagtatggct cccaatgtta gtgtggaaat     3240

aatggtacca aattctttta gcccccaaac tgataagctg ttcaacattt tggatgtcca     3300

gactactact ggagaatgcc actttgaaaa ttatcaaaga gtgtgtgcat tagagcagca     3360

aaagagtgca atgcagacct tgaaaggcat agtccggttc ttgtccaaga ctgataagag     3420

gctattgtac tgcataaaag ctgatccaca ttgtttaaat ttcttgtgta attttgggaa     3480

aatggaaagt ggaaaagaag ccagtgttca tatccaactg gaaggccggc catccatttt     3540

agaaatggat gagacttcag cactcaagtt tgaaataaga gcaacaggtt ttccagagcc     3600

aaatccaaga gtaattgaac taaacaagga tgagaatgtt gcgcatgttc tactggaagg     3660

actacatcat caaagaccca aacgttattt caccatagtg attatttcaa gtagcttgct     3720

acttggactt attgtacttc tgttgatctc atatgttatg tggaaggctg gcttctttaa     3780

aagacaatac aaatctatcc tacaagaaga aaacagaaga gacagttgga gttatatcaa     3840

cagtaaaagc aatgatgatt aaggacttct ttcaaattga gagaatggaa aacagactca     3900

ggttgtagta aagaaattta aaagacactg tttacaagaa aaaatgaatt ttgtttggac     3960

ttcttttact catgatcttg tgacatatta tgtcttcatg caaggggaaa atctcagcaa     4020

tgattactct ttgagataga agaactgcaa aggtaataat acagccaaag ataatctctc     4080

agcttttaaa tgggtagaga aacactaaag cattcaattt attcaagaaa agtaagccct     4140

tgaagatatc ttgaaatgaa agtataactg agttaaatta tactggagaa gtcttagact     4200

tgaaatacta cttaccatat gtgcttgcct cagtaaaatg aaccccactg ggtgggcaga     4260

ggttcatttc aaatacatct ttgatacttg ttcaaaatat gttctttaaa aatataattt     4320

tttagagagc tgttcccaaa ttttctaacg agtggaccat tatcacttta aagcccttta     4380

tttataatac atttcctacg ggctgtgttc caacaaccat tttttttcag cagactatga     4440

atattatagt attataggcc aaactggcaa acttcagact gaacatgtac actggtttga     4500

gcttagtgaa attacttctg gataattatt tttttataat tatggatttc accatctttc     4560

tttctgtata tatacatgtg tttttatgta ggtatatatt taccattctt cctatctatt     4620

cttcctataa cacaccttta tcaagcatac ccaggagtaa tcttcaaatc ttttgttata     4680

ttctgaaaca aaagattgtg agtgttgcac tttacctgat acacgctgat ttagaaaata     4740

cagaaaccat acctcactaa taactttaaa atcaaagctg tgcaaagact agggggccta     4800

tacttcatat gtattatgta ctatgtaaaa tattgactat cacacaacta tttccttgga     4860

tgtaattctt tgttaccctt tacaagtata agtgttacct tacatggaaa cgaagaaaca     4920

aaattcataa atttaaattc ataaatttag ctgaaagata ctgattcaat ttgtatacag     4980

tgaatataaa tgagacgaca gcaaaatttt catgaaatgt aaaatatttt tatagtttgt     5040

tcatactata tgaggttcta ttttaaatga ctttctggat tttaaaaaat ttctttaaat     5100

acaatcattt ttgtaatatt tattttatgc ttatgatcta gataattgca gaatatcatt     5160

ttatctgact ctgccttcat aagagagctg tggccgaatt ttgaacatct gttataggga     5220

gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg aaagatttct ttatatgaag     5280

tccctgccac tagccagcca tcctaattga tgaaagttat ctgttcacag gcctgcagtg     5340

atggtgagga atgttctgag atttgcgaag gcatttgagt agtgaaatgt aagcacaaaa     5400

cctcctgaac ccagagtgtg tatacacagg aataaacttt atgacattta tgtattttta     5460

aaaaactttg tatcgttata aaaaggctag tcattctttc aggagaacat ctaggatcat     5520

agatgaaaaa tcaagccccg atttagaact gtcttctcca ggatggtctc taaggaaatt     5580

tacatttggt tctttcctac tcagaactac tcagaaacaa ctatatattt caggttatct     5640

gagcacagtg aaagcagagt actatggttg tccaacacag gcctctcaga tacaagggga     5700

acacaattac atattgggct agattttgcc cagttcaaaa tagtatttgt tatcaactta     5760

ctttgttact tgtatcatga attttaaaac cctaccactt taagaagaca gggatgggtt     5820

attctttttt ggcaggtagg ctatataact atgtgatttt gaaatttaac tgctctggat     5880

tagggagcag tgaatcaagg cagacttatg aaatctgtat tatatttgta acagaatata     5940

ggaaatttaa cataattgat gagctcaaat cctgaaaaat gaaagaatcc aaattatttc     6000

agaattatct aggttaaata ttgatgtatt atgatggttg caaagttttt ttgtgtgtcc     6060

aataaacaca ttgtaaaaaa aa                                              6082


<210> 6
<211> 1032
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210> 7
<211> 2081
<212> DNA
<213> Homo sapiens

<400> 7
agcatgagtc agacagcctc tggctttctg gaagggcaag gactctatat atacagaggg       60

agcttcctag ctgggatatt ggagcagcaa gaggctggga agccatcact taccttgcac      120

tgagaaagaa gacaaaggcc agtatgcaca gctttcctcc actgctgctg ctgctgttct      180

ggggtgtggt gtctcacagc ttcccagcga ctctagaaac acaagagcaa gatgtggact      240

tagtccagaa atacctggaa aaatactaca acctgaagaa tgatgggagg caagttgaaa      300

agcggagaaa tagtggccca gtggttgaaa aattgaagca aatgcaggaa ttctttgggc      360

tgaaagtgac tgggaaacca gatgctgaaa ccctgaaggt gatgaagcag cccagatgtg      420

gagtgcctga tgtggctcag tttgtcctca ctgaggggaa ccctcgctgg gagcaaacac      480

atctgaccta caggattgaa aattacacgc cagatttgcc aagagcagat gtggaccatg      540

ccattgagaa agccttccaa ctctggagta atgtcacacc tctgacattc accaaggtct      600

ctgagggtca agcagacatc atgatatctt ttgtcagggg agatcatcgg gacaactctc      660

cttttgatgg acctggagga aatcttgctc atgcttttca accaggccca ggtattggag      720

gggatgctca ttttgatgaa gatgaaaggt ggaccaacaa tttcagagag tacaacttac      780

atcgtgttgc agctcatgaa ctcggccatt ctcttggact ctcccattct actgatatcg      840

gggctttgat gtaccctagc tacaccttca gtggtgatgt tcagctagct caggatgaca      900

ttgatggcat ccaagccata tatggacgtt cccaaaatcc tgtccagccc atcggcccac      960

aaaccccaaa agcgtgtgac agtaagctaa cctttgatgc tataactacg attcggggag     1020

aagtgatgtt ctttaaagac agattctaca tgcgcacaaa tcccttctac ccggaagttg     1080

agctcaattt catttctgtt ttctggccac aactgccaaa tgggcttgaa gctgcttacg     1140

aatttgccga cagagatgaa gtccggtttt tcaaagggaa taagtactgg gctgttcagg     1200

gacagaatgt gctacacgga taccccaagg acatctacag ctcctttggc ttccctagaa     1260

ctgtgaagca tatcgatgct gctctttctg aggaaaacac tggaaaaacc tacttctttg     1320

ttgctaacaa atactggagg tatgatgaat ataaacgatc tatggatcca ggttatccca     1380

aaatgatagc acatgacttt cctggaattg gccacaaagt tgatgcagtt ttcatgaaag     1440

atggattttt ctatttcttt catggaacaa gacaatacaa atttgatcct aaaacgaaga     1500

gaattttgac tctccagaaa gctaatagct ggttcaactg caggaaaaat tgaacattac     1560

taatttgaat ggaaaacaca tggtgtgagt ccaaagaagg tgttttcctg aagaactgtc     1620

tattttctca gtcattttta acctctagag tcactgatac acagaatata atcttattta     1680

tacctcagtt tgcatatttt tttactattt agaatgtagc cctttttgta ctgatataat     1740

ttagttccac aaatggtggg tacaaaaagt caagtttgtg gcttatggat tcatataggc     1800

cagagttgca aagatctttt ccagagtatg caactctgac gttgatccca gagagcagct     1860

tcagtgacaa acatatcctt tcaagacaga aagagacagg agacatgagt ctttgccgga     1920

ggaaaagcag ctcaagaaca catgtgcagt cactggtgtc accctggata ggcaagggat     1980

aactcttcta acacaaaata agtgttttat gtttggaata aagtcaacct tgtttctact     2040

gttttataca ctttcaaaaa aaaaaaaaaa aaaaaaaaaa a                         2081


<210> 8
<211> 469
<212> PRT
<213> Homo sapiens

<400> 8
Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210> 9
<211> 1678
<212> DNA
<213> Homo sapiens

<400> 9
gagcaaacag agcagcagaa aaggcagttc ctcttctcca gtgccctcct tccctgtctc       60

tgcctctccc tcccttcctc aggcatcaga gcggagactt cagggagacc agagcccagc      120

ttgccaggca ctgagctaga agccctgcca tggcacccct gagacccctt ctcatactgg      180

ccctgctggc atgggttgct ctggctgacc aagagtcatg caagggccgc tgcactgagg      240

gcttcaacgt ggacaagaag tgccagtgtg acgagctctg ctcttactac cagagctgct      300

gcacagacta tacggctgag tgcaagcccc aagtgactcg cggggatgtg ttcactatgc      360

cggaggatga gtacacggtc tatgacgatg gcgaggagaa aaacaatgcc actgtccatg      420

aacaggtggg gggcccctcc ctgacctctg acctccaggc ccagtccaaa gggaatcctg      480

agcagacacc tgttctgaaa cctgaggaag aggcccctgc gcctgaggtg ggcgcctcta      540

agcctgaggg gatagactca aggcctgaga cccttcatcc agggagacct cagcccccag      600

cagaggagga gctgtgcagt gggaagccct tcgacgcctt caccgacctc aagaacggtt      660

ccctctttgc cttccgaggg cagtactgct atgaactgga cgaaaaggca gtgaggcctg      720

ggtaccccaa gctcatccga gatgtctggg gcatcgaggg ccccatcgat gccgccttca      780

cccgcatcaa ctgtcagggg aagacctacc tcttcaaggg tagtcagtac tggcgctttg      840

aggatggtgt cctggaccct gattaccccc gaaatatctc tgacggcttc gatggcatcc      900

cggacaacgt ggatgcagcc ttggccctcc ctgcccatag ctacagtggc cgggagcggg      960

tctacttctt caaggggaaa cagtactggg agtaccagtt ccagcaccag cccagtcagg     1020

aggagtgtga aggcagctcc ctgtcggctg tgtttgaaca ctttgccatg atgcagcggg     1080

acagctggga ggacatcttc gagcttctct tctggggcag aacctctgct ggtaccagac     1140

agccccagtt cattagccgg gactggcacg gtgtgccagg gcaagtggac gcagccatgg     1200

ctggccgcat ctacatctca ggcatggcac cccgcccctc cttggccaag aaacaaaggt     1260

ttaggcatcg caaccgcaaa ggctaccgtt cacaacgagg ccacagccgt ggccgcaacc     1320

agaactcccg ccggccatcc cgcgccacgt ggctgtcctt gttctccagt gaggagagca     1380

acttgggagc caacaactat gatgactaca ggatggactg gcttgtgcct gccacctgtg     1440

aacccatcca gagtgtcttc ttcttctctg gagacaagta ctaccgagtc aatcttcgca     1500

cacggcgagt ggacactgtg gaccctccct acccacgctc catcgctcag tactggctgg     1560

gctgcccagc tcctggccat ctgtaggagt cagagcccac atggccgggc cctctgtagc     1620

tccctcctcc catctccttc ccccagccca ataaaggtcc cttagccccg agtttaaa       1678


<210> 10
<211> 478
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210> 11
<211> 6549
<212> DNA
<213> Homo sapiens

<400> 11
gcttggagcc gccgcacccg ggacggtgcg tagcgctgga agtccggcct tccgagagct       60

agctgtccgc cgcggccccc gcacgccggg cagccgtccc tcgccgcctc gggcgcgcca      120

ccatggggcc ccggctcagc gtctggctgc tgctgctgcc cgccgccctt ctgctccacg      180

aggagcacag ccgggccgct gcgaagggtg gctgtgctgg ctctggctgt ggcaaatgtg      240

actgccatgg agtgaaggga caaaagggtg aaagaggcct cccggggtta caaggtgtca      300

ttgggtttcc tggaatgcaa ggacctgagg ggccacaggg accaccagga caaaagggtg      360

atactggaga accaggacta cctggaacaa aagggacaag aggacctccg ggagcatctg      420

gctaccctgg aaacccagga cttcccggaa ttcctggcca agacggcccg ccaggccccc      480

caggtattcc aggatgcaat ggcacaaagg gggagagagg gccgctcggg cctcctggct      540

tgcctggttt cgctggaaat cccggaccac caggcttacc agggatgaag ggtgatccag      600

gtgagatact tggccatgtg cccgggatgc tgttgaaagg tgaaagagga tttcccggaa      660

tcccagggac tccaggccca ccaggactgc cagggcttca aggtcctgtt gggcctccag      720

gatttaccgg accaccaggt cccccaggcc ctcccggccc tccaggtgaa aagggacaaa      780

tgggcttaag ttttcaagga ccaaaaggtg acaagggtga ccaaggggtc agtgggcctc      840

caggagtacc aggacaagct caagttcaag aaaaaggaga cttcgccacc aagggagaaa      900

agggccaaaa aggtgaacct ggatttcagg ggatgccagg ggtcggagag aaaggtgaac      960

ccggaaaacc aggacccaga ggcaaacccg gaaaagatgg tgacaaaggg gaaaaaggga     1020

gtcccggttt tcctggtgaa cccgggtacc caggactcat aggccgccag ggcccgcagg     1080

gagaaaaggg tgaagcaggt cctcctggcc cacctggaat tgttataggc acaggacctt     1140

tgggagaaaa aggagagagg ggctaccctg gaactccggg gccaagagga gagccaggcc     1200

caaaaggttt cccaggacta ccaggccaac ccggacctcc aggcctccct gtacctgggc     1260

aggctggtgc ccctggcttc cctggtgaaa gaggagaaaa aggtgaccga ggatttcctg     1320

gtacatctct gccaggacca agtggaagag atgggctccc gggtcctcct ggttcccctg     1380

ggccccctgg gcagcctggc tacacaaatg gaattgtgga atgtcagccc ggacctccag     1440

gtgaccaggg tcctcctgga attccagggc agccaggatt tataggcgaa attggagaga     1500

aaggtcaaaa aggagagagt tgcctcatct gtgatataga cggatatcgg gggcctcccg     1560

ggccacaggg acccccggga gaaataggtt tcccagggca gccaggggcc aagggcgaca     1620

gaggtttgcc tggcagagat ggtgttgcag gagtgccagg ccctcaaggt acaccagggc     1680

tgataggcca gccaggagcc aagggggagc ctggtgagtt ttatttcgac ttgcggctca     1740

aaggtgacaa aggagaccca ggctttccag gacagcccgg catgacaggg agagcgggtt     1800

ctcctggaag agatggccat ccgggtcttc ctggccccaa gggctcgccg ggttctgtag     1860

gattgaaagg agagcgtggc ccccctggag gagttggatt cccaggcagt cgtggtgaca     1920

ccggcccccc tgggcctcca ggatatggtc ctgctggtcc cattggtgac aaaggacaag     1980

caggctttcc tggaggccct ggatccccag gcctgccagg tccaaagggt gaaccaggaa     2040

aaattgttcc tttaccaggc ccccctggag cagaaggact gccggggtcc ccaggcttcc     2100

caggtcccca aggagaccga ggctttcccg gaaccccagg aaggccaggc ctgccaggag     2160

agaagggcgc tgtgggccag ccaggcattg gatttccagg gccccccggc cccaaaggtg     2220

ttgacggctt acctggagac atggggccac cggggactcc aggtcgcccg ggatttaatg     2280

gcttacctgg gaacccaggt gtgcagggcc agaagggaga gcctggagtt ggtctaccgg     2340

gactcaaagg tttgccaggt cttcccggca ttcctggcac acccggggag aaggggagca     2400

ttggggtacc aggcgttcct ggagaacatg gagcgatcgg accccctggg cttcagggga     2460

tcagaggtga accgggacct cctggattgc caggctccgt ggggtctcca ggagttccag     2520

gaataggccc ccctggagct aggggtcccc ctggaggaca gggaccaccg gggttgtcag     2580

gccctcctgg aataaaagga gagaagggtt tccccggatt ccctggactg gacatgccgg     2640

gccctaaagg agataaaggg gctcaaggac tccctggcat aacgggacag tcggggctcc     2700

ctggccttcc tggacagcag ggggctcctg ggattcctgg gtttccaggt tccaagggag     2760

aaatgggcgt catggggacc cccgggcagc cgggctcacc aggaccagtg ggtgctcctg     2820

gattaccggg tgaaaaaggg gaccatggct ttccgggctc ctcaggaccc aggggagacc     2880

ctggcttgaa aggtgataag ggggatgtcg gtctccctgg caagcctggc tccatggata     2940

aggtggacat gggcagcatg aagggccaga aaggagacca aggagagaaa ggacaaattg     3000

gaccaattgg tgagaaggga tcccgaggag accctgggac cccaggagtg cctggaaagg     3060

acgggcaggc aggacagcct gggcagccag gacctaaagg tgatccaggt ataagtggaa     3120

ccccaggtgc tccaggactt ccgggaccaa aaggatctgt tggtggaatg ggcttgccag     3180

gaacacctgg agagaaaggt gtgcctggca tccctggccc acaaggttca cctggcttac     3240

ctggagacaa aggtgcaaaa ggagagaaag ggcaggcagg cccacctggc ataggcatcc     3300

cagggctgcg aggtgaaaag ggagatcaag ggatagcggg tttcccagga agccctggag     3360

agaagggaga aaaaggaagc attgggatcc caggaatgcc agggtcccca ggccttaaag     3420

ggtctcccgg gagtgttggc tatccaggaa gtcctgggct acctggagaa aaaggtgaca     3480

aaggcctccc aggattggat ggcatccctg gtgtcaaagg agaagcaggt cttcctggga     3540

ctcctggccc cacaggccca gctggccaga aaggggagcc aggcagtgat ggaatcccgg     3600

ggtcagcagg agagaagggt gaaccaggtc taccaggaag aggattccca gggtttccag     3660

gggccaaagg agacaaaggt tcaaagggtg aggtgggttt cccaggatta gccgggagcc     3720

caggaattcc tggatccaaa ggagagcaag gattcatggg tcctccgggg ccccagggac     3780

agccggggtt accgggatcc ccaggccatg ccacggaggg gcccaaagga gaccgcggac     3840

ctcagggcca gcctggcctg ccaggacttc cgggacccat ggggcctcca gggcttcctg     3900

ggattgatgg agttaaaggt gacaaaggaa atccaggctg gccaggagca cccggtgtcc     3960

cagggcccaa gggagaccct ggattccagg gcatgcctgg tattggtggc tctccaggaa     4020

tcacaggctc taagggtgat atggggcctc caggagttcc aggatttcaa ggtccaaaag     4080

gtcttcctgg cctccaggga attaaaggtg atcaaggcga tcaaggcgtc ccgggagcta     4140

aaggtctccc gggtcctcct ggccccccag gtccttacga catcatcaaa ggggagcccg     4200

ggctccctgg tcctgagggc cccccagggc tgaaagggct tcagggactg ccaggcccga     4260

aaggccagca aggtgttaca ggattggtgg gtatacctgg acctccaggt attcctgggt     4320

ttgacggtgc ccctggccag aaaggagaga tgggacctgc cgggcctact ggtccaagag     4380

gatttccagg tccaccaggc cccgatgggt tgccaggatc catggggccc ccaggcaccc     4440

catctgttga tcacggcttc cttgtgacca ggcatagtca aacaatagat gacccacagt     4500

gtccttctgg gaccaaaatt ctttaccacg ggtactcttt gctctacgtg caaggcaatg     4560

aacgggccca tggccaggac ttgggcacgg ccggcagctg cctgcgcaag ttcagcacaa     4620

tgcccttcct gttctgcaat attaacaacg tgtgcaactt tgcatcacga aatgactact     4680

cgtactggct gtccacccct gagcccatgc ccatgtcaat ggcacccatc acgggggaaa     4740

acataagacc atttattagt aggtgtgctg tgtgtgaggc gcctgccatg gtgatggccg     4800

tgcacagcca gaccattcag atcccaccgt gccccagcgg gtggtcctcg ctgtggatcg     4860

gctactcttt tgtgatgcac accagcgctg gtgcagaagg ctctggccaa gccctggcgt     4920

cccccggctc ctgcctggag gagtttagaa gtgcgccatt catcgagtgt cacggccgtg     4980

ggacctgcaa ttactacgca aacgcttaca gcttttggct cgccaccata gagaggagcg     5040

agatgttcaa gaagcctacg ccgtccacct tgaaggcagg ggagctgcgc acgcacgtca     5100

gccgctgcca agtctgtatg agaagaacat aatgaagcct gactcagcta atgtcacaac     5160

atggtgctac ttcttcttct ttttgttaac agcaacgaac cctagaaata tatcctgtgt     5220

acctcactgt ccaatatgaa aaccgtaaag tgccttatag gaatttgcgt aactaacaca     5280

ccctgcttca ttgacctcta cttgctgaag gagaaaaaga cagcgataag ctttcaatag     5340

tggcatacca aatggcactt ttgatgaaat aaaatatcaa tattttctgc aatccaatgc     5400

actgatgtgt gaagtgagaa ctccatcaga aaaccaaagg gtgctaggag gtgtgggtgc     5460

cttccatact gtttgcccat tttcattctt gtattataat taattttcta cccccagaga     5520

taaatgtttg tttatatcac tgtctagctg tttcaaaatt taggtccctt ggtctgtaca     5580

aataatagca atgtaaaaat ggttttttga acctccaaat ggaattacag actcagtagc     5640

catatcttcc aaccccccag tataaatttc tgtctttctg ctatgtgtgg tactttgcag     5700

ctgcttttgc agaaatcaca attttcctgt ggaataaaga tggtccaaaa atagtcaaaa     5760

attaaatata tatatatatt agtaatttat atagatgtca gcaattaggc agatcaaggt     5820

ttagtttaac ttccactgtt aaaataaagc ttacatagtt ttcttccttt gaaagactgt     5880

gctgtccttt aacataggtt tttaaagact aggatattga atgtgaaaca tccgttttca     5940

ttgttcactt ctaaaccaaa aattatgtgt tgccaaaacc aaacccaggt tcatgaatat     6000

ggtgtctatt atagtgaaac atgtactttg agcttattgt ttttattctg tattaaatat     6060

tttcagggtt ttaaacacta atcacaaact gaatgacttg acttcaaaag caacaacctt     6120

aaaggccgtc atttcattag tattcctcat tctgcatcct ggcttgaaaa acagctctgt     6180

tgaatcacag tatcagtatt ttcacacgta agcacattcg ggccatttcc gtggtttctc     6240

atgagctgtg ttcacagacc tcagcagggc atcgcatgga ccgcaggagg gcagattcgg     6300

accactaggc ctgaaatgac atttcactaa aagtctccaa aacatttcta agactactaa     6360

ggccttttat gtaatttctt taaatgtgta tttcttaaga attcaaattt gtaataaaac     6420

tatttgtata aaaattaagc ttttattaat ttgttgctag tattgccaca gacgcattaa     6480

aagaaactta ctgcacaagc tgctaataaa tttgtaagct ttgcatacct taaaaaaaaa     6540

aaaaaaaaa                                                             6549


<210> 12
<211> 1669
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly 
        515                 520                 525             


Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly 
    530                 535                 540                 


Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Thr Gly Arg Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro 
                565                 570                 575     


Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly 
            580                 585                 590         


Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr 
        595                 600                 605             


Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly 
    610                 615                 620                 


Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys 
625                 630                 635                 640 


Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser 
                645                 650                 655     


Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly 
        675                 680                 685             


Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro 
    690                 695                 700                 


Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly 
705                 710                 715                 720 


Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val 
                725                 730                 735     


Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly 
            740                 745                 750         


Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu 
        755                 760                 765             


His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro 
    770                 775                 780                 


Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly 
785                 790                 795                 800 


Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro 
                805                 810                 815     


Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly 
            820                 825                 830         


Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln 
        835                 840                 845             


Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly 
    850                 855                 860                 


Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu 
865                 870                 875                 880 


Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val 
                885                 890                 895     


Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly 
            900                 905                 910         


Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp 
        915                 920                 925             


Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly 
    930                 935                 940                 


Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly 
945                 950                 955                 960 


Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val 
                965                 970                 975     


Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys 
            980                 985                 990         


Gly Asp Pro Gly Ile Ser Gly Thr  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Pro Lys  Gly Ser Val Gly Gly  Met Gly Leu Pro Gly  Thr Pro Gly 
    1010                 1015                 1020             


Glu Lys  Gly Val Pro Gly Ile  Pro Gly Pro Gln Gly  Ser Pro Gly 
    1025                 1030                 1035             


Leu Pro  Gly Asp Lys Gly Ala  Lys Gly Glu Lys Gly  Gln Ala Gly 
    1040                 1045                 1050             


Pro Pro  Gly Ile Gly Ile Pro  Gly Leu Arg Gly Glu  Lys Gly Asp 
    1055                 1060                 1065             


Gln Gly  Ile Ala Gly Phe Pro  Gly Ser Pro Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Lys Gly  Ser Ile Gly Ile Pro  Gly Met Pro Gly Ser  Pro Gly Leu 
    1085                 1090                 1095             


Lys Gly  Ser Pro Gly Ser Val  Gly Tyr Pro Gly Ser  Pro Gly Leu 
    1100                 1105                 1110             


Pro Gly  Glu Lys Gly Asp Lys  Gly Leu Pro Gly Leu  Asp Gly Ile 
    1115                 1120                 1125             


Pro Gly  Val Lys Gly Glu Ala  Gly Leu Pro Gly Thr  Pro Gly Pro 
    1130                 1135                 1140             


Thr Gly  Pro Ala Gly Gln Lys  Gly Glu Pro Gly Ser  Asp Gly Ile 
    1145                 1150                 1155             


Pro Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Leu  Pro Gly Arg 
    1160                 1165                 1170             


Gly Phe  Pro Gly Phe Pro Gly  Ala Lys Gly Asp Lys  Gly Ser Lys 
    1175                 1180                 1185             


Gly Glu  Val Gly Phe Pro Gly  Leu Ala Gly Ser Pro  Gly Ile Pro 
    1190                 1195                 1200             


Gly Ser  Lys Gly Glu Gln Gly  Phe Met Gly Pro Pro  Gly Pro Gln 
    1205                 1210                 1215             


Gly Gln  Pro Gly Leu Pro Gly  Ser Pro Gly His Ala  Thr Glu Gly 
    1220                 1225                 1230             


Pro Lys  Gly Asp Arg Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1235                 1240                 1245             


Leu Pro  Gly Pro Met Gly Pro  Pro Gly Leu Pro Gly  Ile Asp Gly 
    1250                 1255                 1260             


Val Lys  Gly Asp Lys Gly Asn  Pro Gly Trp Pro Gly  Ala Pro Gly 
    1265                 1270                 1275             


Val Pro  Gly Pro Lys Gly Asp  Pro Gly Phe Gln Gly  Met Pro Gly 
    1280                 1285                 1290             


Ile Gly  Gly Ser Pro Gly Ile  Thr Gly Ser Lys Gly  Asp Met Gly 
    1295                 1300                 1305             


Pro Pro  Gly Val Pro Gly Phe  Gln Gly Pro Lys Gly  Leu Pro Gly 
    1310                 1315                 1320             


Leu Gln  Gly Ile Lys Gly Asp  Gln Gly Asp Gln Gly  Val Pro Gly 
    1325                 1330                 1335             


Ala Lys  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Tyr Asp 
    1340                 1345                 1350             


Ile Ile  Lys Gly Glu Pro Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1355                 1360                 1365             


Gly Leu  Lys Gly Leu Gln Gly  Leu Pro Gly Pro Lys  Gly Gln Gln 
    1370                 1375                 1380             


Gly Val  Thr Gly Leu Val Gly  Ile Pro Gly Pro Pro  Gly Ile Pro 
    1385                 1390                 1395             


Gly Phe  Asp Gly Ala Pro Gly  Gln Lys Gly Glu Met  Gly Pro Ala 
    1400                 1405                 1410             


Gly Pro  Thr Gly Pro Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Asp 
    1415                 1420                 1425             


Gly Leu  Pro Gly Ser Met Gly  Pro Pro Gly Thr Pro  Ser Val Asp 
    1430                 1435                 1440             


His Gly  Phe Leu Val Thr Arg  His Ser Gln Thr Ile  Asp Asp Pro 
    1445                 1450                 1455             


Gln Cys  Pro Ser Gly Thr Lys  Ile Leu Tyr His Gly  Tyr Ser Leu 
    1460                 1465                 1470             


Leu Tyr  Val Gln Gly Asn Glu  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Ala  Gly Ser Cys Leu Arg  Lys Phe Ser Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Ile Asn Asn Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Glu Pro Met Pro  Met Ser Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Glu Asn  Ile Arg Pro Phe Ile  Ser Arg Cys 
    1535                 1540                 1545             


Ala Val  Cys Glu Ala Pro Ala  Met Val Met Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Ile  Gln Ile Pro Pro Cys  Pro Ser Gly Trp Ser  Ser Leu Trp 
    1565                 1570                 1575             


Ile Gly  Tyr Ser Phe Val Met  His Thr Ser Ala Gly  Ala Glu Gly 
    1580                 1585                 1590             


Ser Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ser  Ala Pro Phe Ile Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ala Asn Ala Tyr Ser  Phe Trp Leu Ala Thr  Ile Glu Arg 
    1625                 1630                 1635             


Ser Glu  Met Phe Lys Lys Pro  Thr Pro Ser Thr Leu  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Arg Thr His Val Ser  Arg Cys Gln Val Cys  Met Arg Arg 
    1655                 1660                 1665             


Thr 
    


<210> 13
<211> 8114
<212> DNA
<213> Homo sapiens

<400> 13
gggagggacg aaccgcgcga ccgagcccta caaaacccgc cccggccgag tggcgaggcg       60

agctttccag ccgggctccc agagccgcgc tgcgcaggag acgcggtggc ctgagagcct      120

gagggtcccc ggactcgccc aggctctgag cgcgcgccca ccatgagcgc ccggaccgcc      180

cccaggccgc aggtgctcct gctgccgctc ctgctggtgc tcctggcggc ggcgcccgca      240

gccagcaagg gttgtgtctg taaagacaaa ggccagtgct tctgtgacgg ggccaaaggg      300

gagaaggggg agaagggctt tcctggaccc cccggttctc ctggccagaa aggattcaca      360

ggtcctgaag gcttgcctgg accgcaggga cccaagggct ttccaggact tccaggactc      420

acgggttcca aaggtgtaag gggaataagt ggattgccag gattttctgg ttctcctgga      480

cttccaggca ccccaggcaa taccgggcct tacggacttg tcggtgtacc aggatgcagt      540

ggttctaagg gtgagcaggg gtttccagga ctcccaggga cactgggcta cccagggatc      600

ccgggtgctg ctggtttgaa aggacaaaag ggtgctcctg ctaaagaaga agatatagaa      660

cttgatgcaa aaggcgaccc cgggttgcca ggggctccag gaccccaggg tttgccaggc      720

cctccaggtt ttcctgggcc tgttggccca cctggtcctc cgggattctt tggctttcca      780

ggagccatgg gacctagagg acctaagggt cacatgggtg aaagagtgat aggacataaa      840

ggagagcggg gtgtgaaagg gttaacagga cccccgggac caccaggaac agttattgtg      900

accctaactg gcccagataa cagaacggac ctcaaggggg aaaagggaga caagggagca      960

atgggcgagc ctggacctcc tggaccctca ggactgcctg gagaatcata tggatctgaa     1020

aagggtgctc ctggagaccc tggcctgcag ggaaaacccg gaaaagatgg tgttcctggc     1080

ttccctggaa gtgagggagt caagggcaac aggggtttcc ctgggttaat gggtgaagat     1140

ggcattaagg gacagaaagg ggacattggc cctccaggat ttcgtggtcc aacagaatat     1200

tatgacacat accaggaaaa gggagatgaa ggcactccag gcccaccagg gcccagagga     1260

gctcgtggcc cacaaggtcc cagtggtccc cccggagttc ctggaagtcc tggatcatca     1320

aggcctggcc tcagaggagc ccctggatgg ccaggcctga aaggaagtaa aggggaacga     1380

ggccgcccag gaaaggatgc catggggact cctgggtccc caggttgtgc tggttcacca     1440

ggtcttccag gatcaccggg acctccagga ccgccaggtg acatcgtttt tcgcaagggt     1500

ccacctggag atcacggact gccaggctat ctagggtctc caggaatccc aggagttgat     1560

gggcccaaag gagaaccagg cctcctgtgt acacagtgcc cttatatccc agggcctccc     1620

ggtctcccag gattgccagg gttacatggt gtaaaaggaa tcccaggaag acaaggcgca     1680

gctggcttga aaggaagccc agggtcccca ggaaatacag gtcttccagg atttccaggt     1740

ttcccaggtg cccagggtga cccaggactt aaaggagaaa aaggtgaaac acttcagcct     1800

gaggggcaag tgggtgtccc aggtgacccg gggctcagag gccaacctgg gagaaagggc     1860

ttggatggaa ttcctggaac tccgggagtg aaaggattac caggacctaa aggcgaactg     1920

gctctgagtg gtgagaaagg ggaccaaggt cctccagggg atcctggctc ccctgggtcc     1980

ccaggacctg caggaccagc tggaccacct ggctacggac cccaaggaga acctggtctc     2040

cagggcacgc aaggagttcc tggagccccc ggaccacccg gagaagccgg ccctagggga     2100

gagctcagtg tttcaacacc agttccaggc ccaccaggac ctccagggcc ccctggccat     2160

cctggccccc aaggtccacc tggtatccct ggatccctgg ggaaatgtgg agatcctggt     2220

cttccagggc ctgatggtga accaggaatt ccaggaattg gatttcctgg gcctcctgga     2280

cctaagggag accaaggttt tccaggtaca aaaggatcac tgggttgtcc tggaaaaatg     2340

ggagagcctg ggttacctgg aaagccaggc ctcccaggag ccaagggaga accagcagta     2400

gccatgcctg gaggaccagg aacaccaggt tttccaggag aaagaggcaa ttctggggaa     2460

catggagaaa ttggactccc tggacttcca ggtctccctg gaactccagg aaatgaaggg     2520

cttgatggac cacgaggaga tccagggcag cctggaccac ctggagaaca aggaccccca     2580

ggaaggtgca tagagggtcc caggggagcc caaggacttc caggcttaaa tggattgaaa     2640

gggcaacaag gcagaagagg taaaacgggg ccaaagggag acccaggaat tccaggcttg     2700

gatagatcag gatttcctgg agaaactgga tcaccaggaa ttccaggtca tcaaggtgaa     2760

atgggaccac tgggtcaaag aggatatcca ggaaatccgg gaattttagg gccaccaggt     2820

gaagatggag tgattgggat gatgggcttt cctggagcca ttggccctcc agggccccct     2880

gggaacccag gcacaccagg gcagaggggg agccctggaa ttccaggagt aaagggccag     2940

agaggaaccc caggagccaa gggggaacaa ggagataaag gaaatcccgg gccttcagag     3000

atatcccacg taatagggga caaaggagaa ccaggtctca aaggattcgc aggaaatcca     3060

ggtgagaaag gaaacagagg cgttccaggg atgccaggtt taaagggcct caaaggacta     3120

cccggaccag caggaccacc aggccccaga ggagatttgg gcagcactgg gaatcctgga     3180

gaaccaggac tgcgtggtat accaggaagc atggggaaca tgggcatgcc aggttctaaa     3240

ggaaaaaggg gaactttggg attcccaggt cgagcaggaa gaccaggcct cccaggtatt     3300

catggtctcc agggagataa gggagagcca ggttattcag aaggtacaag gccaggacca     3360

ccgggaccaa cgggggatcc aggactgccg ggtgatatgg gaaagaaagg agaaatgggg     3420

caacctggcc cacctggaca tttggggcct gctggacctg agggagcccc tggaagtcct     3480

ggaagtcctg gcctcccagg aaagccaggt cctcatggtg atttgggttt taaaggaatc     3540

aaaggcctcc tgggccctcc aggaatcaga ggccctccag gtcttccagg atttccagga     3600

tctcctggac caatgggtat aagaggtgac caaggacgtg atggaattcc tggtccagcc     3660

ggagaaaagg gagaaacggg tttattgagg gcccctccag gcccaagagg gaaccctggt     3720

gctcaaggag ccaaaggaga caggggagcc ccaggttttc ctggcctccc gggcagaaaa     3780

ggggccatgg gagatgctgg acctcgagga cccacaggca tagaaggatt cccagggcca     3840

ccaggtctgc ccggtgcaat tatccctggc cagacaggaa atcgtggtcc accaggctca     3900

agaggaagcc caggtgcgcc tggtccccct ggacctccag ggagtcatgt aataggcata     3960

aaaggagaca aagggtctat gggccaccct ggcccaaaag gtccacctgg aactgcagga     4020

gacatgggac caccaggtcg tctgggagca ccaggtactc caggtcttcc aggacccaga     4080

ggtgatcctg gattccaggg gtttccaggc gtgaaaggag aaaagggtaa tcctggattt     4140

ctaggatcca ttggacctcc aggaccaatt gggccaaaag gaccacctgg tgtacgtgga     4200

gaccctggca cacttaagat tatctccctt ccaggaagcc cagggccacc tggcacacct     4260

ggagaaccag ggatgcaggg agaacctggg ccaccagggc cacctggaaa cctaggaccc     4320

tgtgggccaa gaggtaagcc aggcaaggat ggaaaaccag gaactcctgg accagctgga     4380

gaaaaaggca acaaaggttc taaaggagag ccaggaccag ctggatcaga tggattgcca     4440

ggtttgaaag gaaaacgtgg agacagtgga tcacctgcaa cctggacaac gagaggcttt     4500

gtcttcaccc gacacagtca aaccacagca attccttcat gtccagaggg gacagtgcca     4560

ctctacagtg ggttttcttt tctttttgta caaggaaatc aacgagccca cggacaagac     4620

cttggaactc ttggcagctg cctgcagcga tttaccacaa tgccattctt attctgcaat     4680

gtcaatgatg tatgtaattt tgcatctcga aatgattatt catactggct gtcaacacca     4740

gctctgatgc caatgaacat ggctcccatt actggcagag cccttgagcc ttatataagc     4800

agatgcactg tttgtgaagg tcctgcgatc gccatagccg ttcacagcca aaccactgac     4860

attcctccat gtcctcacgg ctggatttct ctctggaaag gattttcatt catcatgttc     4920

acaagtgcag gttctgaggg caccgggcaa gcactggcct cccctggctc ctgcctggaa     4980

gaattccgag ccagcccatt tctagaatgt catggaagag gaacgtgcaa ctactattca     5040

aattcctaca gtttctggct ggcttcatta aacccagaaa gaatgttcag aaagcctatt     5100

ccatcaactg tgaaagctgg ggaattagaa aaaataataa gtcgctgtca ggtgtgcatg     5160

aagaaaagac actgaagcta aaaaagacag cagaactgct atttttcatc ctaaagaaca     5220

aagtaatgac agaacatgct gttatttagg tatttttctt taaccaaaca atattgctcc     5280

atgatgactt agtacaaagt ttcaatttgt ttccccacaa aacaaagcaa ttctttcaag     5340

tcagttctgt gatctgggtc tctaatctgt gctgtttcaa agttctctgt ggcaaagcag     5400

caactattca caaaatatca ccaaaaacct attccactta catccaaggc actgtcacta     5460

cggtgattgt atgaagtttg aatgctgcaa gttatgaaat atttggcccg ctggattccc     5520

acatttgtct tctttctgtc tttaagactc agggaggcta aatcagtgtt tgattgcccc     5580

gccaaccctt cctgaaactt cagaccctgg gtaggggaag agaagggggc atgtggtatc     5640

ctggagcatt gtgtatagaa ctggattttc agacctgctg aggaccgtaa ggcctgatgg     5700

aacacagaac tgaactgagg ttcatggatt ttccaggact gtttcaaaca tgcccattac     5760

taacggcaaa agggggattc cctgatggaa ccataatacc cttggaaata ctgtatggtt     5820

ttgttttgtt ttgttggttt ttaaagattt ttgtttgttt attgaattca tttcactgta     5880

gctctaaaat ctgcttgtat tccaagcata taaaattttc ccccttagtg aattagtttt     5940

aaaatgatat tgttatatac atactatgaa atatgtataa ctttaacttc tgttttacca     6000

gcatacccac acaaataaca agaatactac ttatgaaatg tgcactttat cctcattcca     6060

taaatgtcgg tgcatacctt atgtaaggga gcagttcaat aatccatgaa agaacttaag     6120

gcatttgttg gtttatcaga ctcggaatct attttctcat tgctctgaat atgtcatcac     6180

tctaggtttt acagatttat tcctttgtta cttctctaat tcttcctttg taaaaaaaaa     6240

aaaaagcaac actttttatg ttatatgttg ttcttacaaa ccatactgaa agagtccatt     6300

gtttaaaaat cttaatgtat caaactgtat aacttggccg ctgtatgtct taaaacctgc     6360

ttttcaatgt gttgatacat tcccaaggtt acttaattca acttaactat catcttattc     6420

agcaccaagc atgtcccagg cactgtacta acctacagag atgctaagag aaaaaaaaga     6480

cttgtttctg atctaatatc ccagaaaaag taactcattg ctctgttaat aatctcacat     6540

atacaagtag cttccctccc ctctagtttt ttcttccttt tcactgctgt tatatttcat     6600

catgataatt cagcaggccc aagtaaaggt taaaaataag gtctatgcct agggaaactc     6660

agggcttcta gtttctctta gaaaagctaa gagaagataa ggtctgaata atagcagaaa     6720

aaccaacatc tacaaaacat taaactagtg ttatacttga tgataacact atttgatgag     6780

tcttagagtc cagacacaaa gagacaaagc tttgaagatg ctttttgatc tacctaggtg     6840

gagttggtgg tgctgatatt taaattcagg ctactgcttc aatctcaatt gctttgtaag     6900

tgaaaaacat gacccagagg acagcacaga ctatggccat ggctcacatg gtttacatcc     6960

ttcactgctc acgtgtttgc tgtcaagcca tttttacatc taaactaaga tgtgcagcat     7020

ttcacttatt tagattcact taacaaacaa atttttctgc tttaaaaatg tcttattgtc     7080

ccaagtgtac tatagcggca tatagagcta gctaatctct acaaaccctc tgtaggccag     7140

tagttctcaa agtgtggtct ctggaagagc agtatcagca tcatctggga acttgtcaca     7200

gatgcagatt ctagggacca ctccagacct acacaatcag aaactcttgg gggagggccc     7260

gaaatatcta tgttttacca agcccaccac atgattctga tgtactctaa atactgagaa     7320

aacctgttct agacaaatac ccaagcaaca actccgcagg cagttaccaa gtacggctgg     7380

ctacaactgc tccatccgtg cctcttttta aagttcaaac tcacaggtga ctctaaggtt     7440

atctactttt actcataagt aaaagcccta gactggtgct aatgtcaaac cactggcctc     7500

cactcaggcc tccatcttct catgccctct taccagtatt taacttctga ggaagacaag     7560

tgatgctaaa acctgaaatt ccaatgaagc catatgaaca gctgttcagt tgcacttcta     7620

agactttact tagcagtaaa ttatagctca tgtgcattat tttccagata acttagctta     7680

tgagtagctt atacaattat gaagatttaa tattacagat aaaatgtaaa ctgtttcttt     7740

aaaattgggg cttcaacttt ggaatttcac agcgtgctaa aataacagat ttctcagaag     7800

tctttcagca agataaacat tattaagtaa cttatttatg aaagtattaa aatgcttaca     7860

tttgaacttg atggctaact tacaaagatt ctctatgtat caaatgtaac ttactgcgac     7920

taaacttaat ttaatattta ctctataacc aaatgaaata tatttaaaat atattgaata     7980

ttttatattg ttatatcctg acaagattat aatattttaa tgtactaata tttctgtaat     8040

tatatctaaa atattatttt attatattgc ctaagaataa acatttgtta aattggaaaa     8100

aaaaaaaaaa aaaa                                                       8114


<210> 14
<211> 1670
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Thr Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Thr Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Thr Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210> 15
<211> 6192
<212> DNA
<213> Homo sapiens

<400> 15
gcgagtgact gcaccgagcc cgagaagtcg ccgcgccccg cagccgcccc gactggttcc       60

ccgccttgcc cgtgggcccc gccgggatgg ggaaccgccg ggacctgggc cagccgcggg      120

ccggtctctg cctgctcctg gccgcgctgc agcttctgcc ggggacgcag gccgatcctg      180

tggatgtcct gaaggccctg ggtgtgcagg gaggccaggc tggggtcccc gaggggcctg      240

gcttctgtcc ccagaggact ccagagggtg accgggcatt cagaattggc caggccagca      300

cgctcggcat ccccacgtgg gaactctttc cagaaggcca ctttcctgag aacttctcct      360

tgctgatcac cttgcgggga cagccagcca atcagtctgt cctgctgtcc atttatgatg      420

aaaggggtgc ccggcagttg ggcctggcac tggggccagc gctgggtctc ctaggtgacc      480

ccttccgccc cctcccccag caggtcaacc tcacagatgg caggtggcac cgtgtggccg      540

tcagcataga tggtgagatg gtgaccctgg tagctgactg tgaagctcag ccccctgttt      600

tgggccatgg cccccgcttc atcagcatag ctggactcac tgtgctgggg acccaggacc      660

ttggggaaaa gactttcgag ggagacattc aggagctgct gataagccca gatcctcagg      720

ctgccttcca ggcttgtgag cggtacctcc ccgactgtga caacctggca ccggcagcca      780

cagtggctcc ccagggtgaa ccagaaaccc ctcgtcctcg gcggaagggg aagggaaaag      840

ggaggaagaa agggcgaggt cgcaagggga agggcaggaa aaagaacaag gaaatttgga      900

cctcaagtcc acctcctgac tccgcagaga accagacctc cactgacatc cccaagacag      960

agactccagc tccaaatctg cctccgaccc ccacgccttt ggtcgtcacc tccactgtga     1020

ctactggact caatgccacg atcctagaga ggagcttgga ccctgacagt ggaaccgagc     1080

tggggaccct ggagaccaag gcagccaggg aggatgaaga aggagatgat tccaccatgg     1140

gccctgactt ccgggcagca gaatatccat ctcggactca gttccagatc tttcctggtg     1200

ctggagagaa aggagcaaaa ggagagcccg cagtgattga aaaggggcag cagtttgagg     1260

gacctccagg agccccagga ccccaagggg tggttggccc ctcaggccct cccggccccc     1320

caggattccc tggcgaccct ggtccaccgg gccctgctgg cctcccagga atccccggca     1380

ttgatgggat ccgaggccca ccgggcactg tgatcatgat gccgttccag tttgcaggcg     1440

gctcctttaa aggcccccca gtctcattcc agcaggccca ggctcaggca gttctgcagc     1500

agactcagct ctctatgaaa ggcccccctg gtccagtggg gctcactggg cgcccaggcc     1560

ctgtgggtct ccccgggcat ccaggtctga aaggagagga gggagcagaa gggccacagg     1620

gtccccgagg cctgcaggga cctcatggac cccctggccg agtgggcaag atgggccgcc     1680

ctggagcaga tggagctcgg ggcctcccag gggacactgg acctaagggt gatcgtggct     1740

tcgatggcct ccctgggctg cctggtgaga agggccaaag gggtgacttt ggccatgtgg     1800

ggcaacccgg tcccccagga gaggatggtg agaggggagc agagggacct ccagggccca     1860

ctggccaggc tggggagccg ggtccacgag gactgcttgg ccccagaggc tctcctggcc     1920

ccacgggtcg cccgggtgtg actggaattg atggtgctcc tggtgccaaa ggcaatgtgg     1980

gtcctccagg agaaccaggc cctccgggac agcagggaaa ccatgggtcc cagggactcc     2040

ccggtcccca gggactcatt ggcactcctg gggagaaggg tccccctgga aacccaggaa     2100

ttccaggcct cccaggatcc gatggccctc tgggtcaccc aggacatgag ggccccacgg     2160

gagagaaagg ggctcagggt ccaccagggt cggcaggccc tccgggctat cctggacctc     2220

ggggagtgaa gggcacttca ggcaaccggg gcctccaggg ggagaaaggc gagaagggag     2280

aggacggctt cccaggcttc aagggcgatg tggggctcaa aggtgatcag gggaaacccg     2340

gagctccagg tccccgggga gaggatggtc ctgaggggcc gaaggggcag gcggggcagg     2400

ctggcgagga ggggccccca ggctcagctg gggagaaggg caagcttggg gtgccaggcc     2460

tcccaggtta tccaggacgc cctggaccta agggatctat tggatttccc ggtcccctgg     2520

gacccatagg agagaaaggg aagtcgggaa agacagggca gccaggcctg gaaggagagc     2580

ggggaccacc aggttcccgt ggagagaggg ggcaaccggg tgccacaggg caaccaggcc     2640

ccaagggcga tgtgggccag gatggagccc ctgggatccc tggagaaaag ggcctccctg     2700

gtctgcaagg ccctccagga ttccctgggc caaagggccc ccctggtcac caaggtaaag     2760

atgggcgacc agggcaccct ggacagagag gagaactggg cttccaaggt cagacaggcc     2820

cgcctggacc agctggtgtc ttaggccctc agggaaagac aggagaagtg ggacctctag     2880

gtgaaagggg gcctccaggc ccccctggac ctcctggtga acaaggtctt cctggcctgg     2940

aaggcagaga gggggccaag ggggaactgg gaccaccagg accccttggg aaagaagggc     3000

cagctggact caggggcttt cccggcccca aagggggccc tggggacccg ggacctactg     3060

gcttaaaggg tgataagggc cccccagggc ccgtgggggc caatggctcc cctggtgagc     3120

gcggtccttt gggcccagca ggaggcattg gacttcctgg ccaaagtggc agcgaaggcc     3180

ccgttggccc tgcaggcaag aaggggtccc ggggagaacg tggcccccct ggccccactg     3240

gcaaagatgg gatcccaggg cccctggggc ctctgggacc ccctggagct gctgggcctt     3300

ctggcgagga aggggacaag ggggatgtgg gtgcccccgg acacaagggg agtaaaggcg     3360

ataaaggaga cgcgggccca cctggacaac cagggatacg gggtcctgca ggacacccag     3420

gtcccccggg agcagacggg gctcaggggc gccggggacc cccaggcctc tttgggcaga     3480

aaggagatga cggagtcaga ggctttgtgg gggtgattgg ccctcctgga ctgcaggggc     3540

tgccaggccc tccgggagag aaaggggagg tcggagacgt cgggtccatg ggtccccatg     3600

gagctccagg tcctcggggt ccccaaggcc ccactggatc agagggcact ccagggctgc     3660

ctggaggagt tggtcagcca ggcgccgtgg gtgagaaggg tgagcgaggg gacgctggag     3720

acccagggcc tccaggagcc ccaggcatcc cggggcccaa gggagacatt ggtgaaaagg     3780

gggactcagg cccatctgga gctgctggac ccccaggcaa gaaaggtccc cctggagagg     3840

atggagccaa agggagcgtg ggccccacgg ggctgcccgg agatctaggg cccccaggag     3900

accctggagt ttcaggcata gatggttccc caggggagaa gggagaccct ggtgatgttg     3960

ggggaccggg tccgcctgga gcttctgggg agcccggcgc ccccgggccc cccggcaaga     4020

ggggtccttc aggccacatg ggtcgagaag gcagagaagg ggagaaaggt gccaaggggg     4080

agccaggtcc tgatgggccc ccagggagga cgggtccaat gggggctaga gggccccctg     4140

gacgtgtggg gcctgagggt cttcgaggga tccctggccc tgtgggtgaa ccaggcctcc     4200

tgggagcccc tggacagatg ggccctcctg gccccctggg gccctctggc ctcccagggc     4260

tgaagggaga cactggcccc aagggggaaa agggccacat tggattgatc ggtctcattg     4320

gccccccggg agaagctggt gagaaaggag atcaggggtt gccaggcgtg cagggacccc     4380

ctggtcccaa gggagaccct ggtccccctg gtcccattgg ctctctgggc caccctgggc     4440

ccccaggtgt ggcgggccct ctaggacaga aaggctcaaa agggtctccg gggtccatgg     4500

gcccccgtgg agacactgga cctgcaggcc caccaggccc cccgggtgcc cctgccgagc     4560

tgcatgggct gcgcaggcgc cggcgcttcg tcccagtccc gcttccagtc gtggagggcg     4620

gcctggagga ggtgctggcc tcgctcacat cgctgagctt ggagctggag cagctgcggc     4680

gtcctcccgg cactgcggag cgcccgggcc tcgtgtgcca cgagctgcac cgcaaccacc     4740

cgcacctgcc tgatggggaa tactggattg accccaacca gggctgcgcg cgggactcgt     4800

tcagggtttt ttgcaacttc acggcgggag gagagacctg cctctatccc gacaagaagt     4860

ttgagatcgt gaaattggcc tcctggtcca aggaaaagcc tggaggctgg tatagcacat     4920

tccgtcgagg gaagaagttc tcctacgtgg acgccgacgg gtccccagtg aatgtcgtgc     4980

agctgaactt cctgaaactg ctgagtgcca cagctcgcca gaacttcacc tactcctgcc     5040

agaatgcagc tgcctggctg gacgaagcca cgggtgacta cagccactcc gcccgcttcc     5100

ttggcaccaa tggagaggag ctgtctttca accagacgac agcagccact gtcagcgtcc     5160

cccaggatgg ctgccggctc cggaaaggac agacgaagac ccttttcgaa ttcagctctt     5220

ctcgagcggg atttctgccc ctgtgggatg tggcggccac tgactttggc cagacgaacc     5280

aaaagtttgg gtttgaactg ggccccgtct gcttcagcag ctgagagtgt ccggggtggg     5340

agggaccatg agggagcccc agaatggggt gcatttggtg ctgaggcttt gaagccaccg     5400

tatttttcgt tacctgtgac tatggagcca atgggatgtg acttcgctca tcacggacag     5460

tcattccttc tcctttccag ggtgctgggg gctggggttc cctggcccaa gggtccagcc     5520

tcctctcacc ccattccagg tggcatactg cagtctggct ctttctcccc tccctcccca     5580

cccaagcctc acctccccac cccttgaacc cccatgcaat gagcttctaa ctcagagctg     5640

atgaacaaaa gcccccccac ccccaatgcc tgcctcctca ctcctccgtc gctgcccttc     5700

acaccttttg gtgctacccc tccccagagt taagcactgg atgtctcctg atcccaggct     5760

gggaccccta cccccacccc ctttgatcct ttctacttcc acggtgaaag gactgaggtc     5820

ggactacaga gggaagaggg acttcccttg actgggttgt gtttcttttc ctgcctcagc     5880

ccagctctgc aaatcccctc cccctgcccc ccacctcccc aggctcacct tgccatgcca     5940

ggtggtttgg ggaccaagat gttggggggg tgaatcagga tcctaatggt gctgccctat     6000

ttatacctgg gtctgtatta aaagggaaag tcccccctgt tgtagatttc atctgcttcc     6060

tccttaggga aggctgggat atgatgagag attccagccc aagcctggcc ccccaccgcc     6120

aggccatagg gcataatttg catctcaaat ctgagaataa actgatgaac tgtgaaaaaa     6180

aaaaaaaaaa aa                                                         6192


<210> 16
<211> 1745
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Asn Arg Arg Asp Leu Gly Gln Pro Arg Ala Gly Leu Cys Leu 
1               5                   10                  15      


Leu Leu Ala Ala Leu Gln Leu Leu Pro Gly Thr Gln Ala Asp Pro Val 
            20                  25                  30          


Asp Val Leu Lys Ala Leu Gly Val Gln Gly Gly Gln Ala Gly Val Pro 
        35                  40                  45              


Glu Gly Pro Gly Phe Cys Pro Gln Arg Thr Pro Glu Gly Asp Arg Ala 
    50                  55                  60                  


Phe Arg Ile Gly Gln Ala Ser Thr Leu Gly Ile Pro Thr Trp Glu Leu 
65                  70                  75                  80  


Phe Pro Glu Gly His Phe Pro Glu Asn Phe Ser Leu Leu Ile Thr Leu 
                85                  90                  95      


Arg Gly Gln Pro Ala Asn Gln Ser Val Leu Leu Ser Ile Tyr Asp Glu 
            100                 105                 110         


Arg Gly Ala Arg Gln Leu Gly Leu Ala Leu Gly Pro Ala Leu Gly Leu 
        115                 120                 125             


Leu Gly Asp Pro Phe Arg Pro Leu Pro Gln Gln Val Asn Leu Thr Asp 
    130                 135                 140                 


Gly Arg Trp His Arg Val Ala Val Ser Ile Asp Gly Glu Met Val Thr 
145                 150                 155                 160 


Leu Val Ala Asp Cys Glu Ala Gln Pro Pro Val Leu Gly His Gly Pro 
                165                 170                 175     


Arg Phe Ile Ser Ile Ala Gly Leu Thr Val Leu Gly Thr Gln Asp Leu 
            180                 185                 190         


Gly Glu Lys Thr Phe Glu Gly Asp Ile Gln Glu Leu Leu Ile Ser Pro 
        195                 200                 205             


Asp Pro Gln Ala Ala Phe Gln Ala Cys Glu Arg Tyr Leu Pro Asp Cys 
    210                 215                 220                 


Asp Asn Leu Ala Pro Ala Ala Thr Val Ala Pro Gln Gly Glu Pro Glu 
225                 230                 235                 240 


Thr Pro Arg Pro Arg Arg Lys Gly Lys Gly Lys Gly Arg Lys Lys Gly 
                245                 250                 255     


Arg Gly Arg Lys Gly Lys Gly Arg Lys Lys Asn Lys Glu Ile Trp Thr 
            260                 265                 270         


Ser Ser Pro Pro Pro Asp Ser Ala Glu Asn Gln Thr Ser Thr Asp Ile 
        275                 280                 285             


Pro Lys Thr Glu Thr Pro Ala Pro Asn Leu Pro Pro Thr Pro Thr Pro 
    290                 295                 300                 


Leu Val Val Thr Ser Thr Val Thr Thr Gly Leu Asn Ala Thr Ile Leu 
305                 310                 315                 320 


Glu Arg Ser Leu Asp Pro Asp Ser Gly Thr Glu Leu Gly Thr Leu Glu 
                325                 330                 335     


Thr Lys Ala Ala Arg Glu Asp Glu Glu Gly Asp Asp Ser Thr Met Gly 
            340                 345                 350         


Pro Asp Phe Arg Ala Ala Glu Tyr Pro Ser Arg Thr Gln Phe Gln Ile 
        355                 360                 365             


Phe Pro Gly Ala Gly Glu Lys Gly Ala Lys Gly Glu Pro Ala Val Ile 
    370                 375                 380                 


Glu Lys Gly Gln Gln Phe Glu Gly Pro Pro Gly Ala Pro Gly Pro Gln 
385                 390                 395                 400 


Gly Val Val Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly 
                405                 410                 415     


Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ile Pro Gly Ile 
            420                 425                 430         


Asp Gly Ile Arg Gly Pro Pro Gly Thr Val Ile Met Met Pro Phe Gln 
        435                 440                 445             


Phe Ala Gly Gly Ser Phe Lys Gly Pro Pro Val Ser Phe Gln Gln Ala 
    450                 455                 460                 


Gln Ala Gln Ala Val Leu Gln Gln Thr Gln Leu Ser Met Lys Gly Pro 
465                 470                 475                 480 


Pro Gly Pro Val Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Leu Pro 
                485                 490                 495     


Gly His Pro Gly Leu Lys Gly Glu Glu Gly Ala Glu Gly Pro Gln Gly 
            500                 505                 510         


Pro Arg Gly Leu Gln Gly Pro His Gly Pro Pro Gly Arg Val Gly Lys 
        515                 520                 525             


Met Gly Arg Pro Gly Ala Asp Gly Ala Arg Gly Leu Pro Gly Asp Thr 
    530                 535                 540                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Glu Lys Gly Gln Arg Gly Asp Phe Gly His Val Gly Gln Pro Gly Pro 
                565                 570                 575     


Pro Gly Glu Asp Gly Glu Arg Gly Ala Glu Gly Pro Pro Gly Pro Thr 
            580                 585                 590         


Gly Gln Ala Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly 
        595                 600                 605             


Ser Pro Gly Pro Thr Gly Arg Pro Gly Val Thr Gly Ile Asp Gly Ala 
    610                 615                 620                 


Pro Gly Ala Lys Gly Asn Val Gly Pro Pro Gly Glu Pro Gly Pro Pro 
625                 630                 635                 640 


Gly Gln Gln Gly Asn His Gly Ser Gln Gly Leu Pro Gly Pro Gln Gly 
                645                 650                 655     


Leu Ile Gly Thr Pro Gly Glu Lys Gly Pro Pro Gly Asn Pro Gly Ile 
            660                 665                 670         


Pro Gly Leu Pro Gly Ser Asp Gly Pro Leu Gly His Pro Gly His Glu 
        675                 680                 685             


Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Pro Pro Gly Ser Ala Gly 
    690                 695                 700                 


Pro Pro Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Thr Ser Gly Asn 
705                 710                 715                 720 


Arg Gly Leu Gln Gly Glu Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                725                 730                 735     


Gly Phe Lys Gly Asp Val Gly Leu Lys Gly Asp Gln Gly Lys Pro Gly 
            740                 745                 750         


Ala Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Gln 
        755                 760                 765             


Ala Gly Gln Ala Gly Glu Glu Gly Pro Pro Gly Ser Ala Gly Glu Lys 
    770                 775                 780                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Pro Gly 
785                 790                 795                 800 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Pro Leu Gly Pro Ile Gly Glu 
                805                 810                 815     


Lys Gly Lys Ser Gly Lys Thr Gly Gln Pro Gly Leu Glu Gly Glu Arg 
            820                 825                 830         


Gly Pro Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ala Thr Gly 
        835                 840                 845             


Gln Pro Gly Pro Lys Gly Asp Val Gly Gln Asp Gly Ala Pro Gly Ile 
    850                 855                 860                 


Pro Gly Glu Lys Gly Leu Pro Gly Leu Gln Gly Pro Pro Gly Phe Pro 
865                 870                 875                 880 


Gly Pro Lys Gly Pro Pro Gly His Gln Gly Lys Asp Gly Arg Pro Gly 
                885                 890                 895     


His Pro Gly Gln Arg Gly Glu Leu Gly Phe Gln Gly Gln Thr Gly Pro 
            900                 905                 910         


Pro Gly Pro Ala Gly Val Leu Gly Pro Gln Gly Lys Thr Gly Glu Val 
        915                 920                 925             


Gly Pro Leu Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940                 


Glu Gln Gly Leu Pro Gly Leu Glu Gly Arg Glu Gly Ala Lys Gly Glu 
945                 950                 955                 960 


Leu Gly Pro Pro Gly Pro Leu Gly Lys Glu Gly Pro Ala Gly Leu Arg 
                965                 970                 975     


Gly Phe Pro Gly Pro Lys Gly Gly Pro Gly Asp Pro Gly Pro Thr Gly 
            980                 985                 990         


Leu Lys Gly Asp Lys Gly Pro Pro  Gly Pro Val Gly Ala  Asn Gly Ser 
        995                 1000                 1005             


Pro Gly  Glu Arg Gly Pro Leu  Gly Pro Ala Gly Gly  Ile Gly Leu 
    1010                 1015                 1020             


Pro Gly  Gln Ser Gly Ser Glu  Gly Pro Val Gly Pro  Ala Gly Lys 
    1025                 1030                 1035             


Lys Gly  Ser Arg Gly Glu Arg  Gly Pro Pro Gly Pro  Thr Gly Lys 
    1040                 1045                 1050             


Asp Gly  Ile Pro Gly Pro Leu  Gly Pro Leu Gly Pro  Pro Gly Ala 
    1055                 1060                 1065             


Ala Gly  Pro Ser Gly Glu Glu  Gly Asp Lys Gly Asp  Val Gly Ala 
    1070                 1075                 1080             


Pro Gly  His Lys Gly Ser Lys  Gly Asp Lys Gly Asp  Ala Gly Pro 
    1085                 1090                 1095             


Pro Gly  Gln Pro Gly Ile Arg  Gly Pro Ala Gly His  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Asp Gly Ala Gln  Gly Arg Arg Gly Pro  Pro Gly Leu 
    1115                 1120                 1125             


Phe Gly  Gln Lys Gly Asp Asp  Gly Val Arg Gly Phe  Val Gly Val 
    1130                 1135                 1140             


Ile Gly  Pro Pro Gly Leu Gln  Gly Leu Pro Gly Pro  Pro Gly Glu 
    1145                 1150                 1155             


Lys Gly  Glu Val Gly Asp Val  Gly Ser Met Gly Pro  His Gly Ala 
    1160                 1165                 1170             


Pro Gly  Pro Arg Gly Pro Gln  Gly Pro Thr Gly Ser  Glu Gly Thr 
    1175                 1180                 1185             


Pro Gly  Leu Pro Gly Gly Val  Gly Gln Pro Gly Ala  Val Gly Glu 
    1190                 1195                 1200             


Lys Gly  Glu Arg Gly Asp Ala  Gly Asp Pro Gly Pro  Pro Gly Ala 
    1205                 1210                 1215             


Pro Gly  Ile Pro Gly Pro Lys  Gly Asp Ile Gly Glu  Lys Gly Asp 
    1220                 1225                 1230             


Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro Gly Lys  Lys Gly Pro 
    1235                 1240                 1245             


Pro Gly  Glu Asp Gly Ala Lys  Gly Ser Val Gly Pro  Thr Gly Leu 
    1250                 1255                 1260             


Pro Gly  Asp Leu Gly Pro Pro  Gly Asp Pro Gly Val  Ser Gly Ile 
    1265                 1270                 1275             


Asp Gly  Ser Pro Gly Glu Lys  Gly Asp Pro Gly Asp  Val Gly Gly 
    1280                 1285                 1290             


Pro Gly  Pro Pro Gly Ala Ser  Gly Glu Pro Gly Ala  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Lys Arg Gly Pro Ser  Gly His Met Gly Arg  Glu Gly Arg 
    1310                 1315                 1320             


Glu Gly  Glu Lys Gly Ala Lys  Gly Glu Pro Gly Pro  Asp Gly Pro 
    1325                 1330                 1335             


Pro Gly  Arg Thr Gly Pro Met  Gly Ala Arg Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Val Gly  Pro Glu Gly Leu Arg  Gly Ile Pro Gly Pro  Val Gly Glu 
    1355                 1360                 1365             


Pro Gly  Leu Leu Gly Ala Pro  Gly Gln Met Gly Pro  Pro Gly Pro 
    1370                 1375                 1380             


Leu Gly  Pro Ser Gly Leu Pro  Gly Leu Lys Gly Asp  Thr Gly Pro 
    1385                 1390                 1395             


Lys Gly  Glu Lys Gly His Ile  Gly Leu Ile Gly Leu  Ile Gly Pro 
    1400                 1405                 1410             


Pro Gly  Glu Ala Gly Glu Lys  Gly Asp Gln Gly Leu  Pro Gly Val 
    1415                 1420                 1425             


Gln Gly  Pro Pro Gly Pro Lys  Gly Asp Pro Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Ile Gly  Ser Leu Gly His Pro  Gly Pro Pro Gly Val  Ala Gly Pro 
    1445                 1450                 1455             


Leu Gly  Gln Lys Gly Ser Lys  Gly Ser Pro Gly Ser  Met Gly Pro 
    1460                 1465                 1470             


Arg Gly  Asp Thr Gly Pro Ala  Gly Pro Pro Gly Pro  Pro Gly Ala 
    1475                 1480                 1485             


Pro Ala  Glu Leu His Gly Leu  Arg Arg Arg Arg Arg  Phe Val Pro 
    1490                 1495                 1500             


Val Pro  Leu Pro Val Val Glu  Gly Gly Leu Glu Glu  Val Leu Ala 
    1505                 1510                 1515             


Ser Leu  Thr Ser Leu Ser Leu  Glu Leu Glu Gln Leu  Arg Arg Pro 
    1520                 1525                 1530             


Pro Gly  Thr Ala Glu Arg Pro  Gly Leu Val Cys His  Glu Leu His 
    1535                 1540                 1545             


Arg Asn  His Pro His Leu Pro  Asp Gly Glu Tyr Trp  Ile Asp Pro 
    1550                 1555                 1560             


Asn Gln  Gly Cys Ala Arg Asp  Ser Phe Arg Val Phe  Cys Asn Phe 
    1565                 1570                 1575             


Thr Ala  Gly Gly Glu Thr Cys  Leu Tyr Pro Asp Lys  Lys Phe Glu 
    1580                 1585                 1590             


Ile Val  Lys Leu Ala Ser Trp  Ser Lys Glu Lys Pro  Gly Gly Trp 
    1595                 1600                 1605             


Tyr Ser  Thr Phe Arg Arg Gly  Lys Lys Phe Ser Tyr  Val Asp Ala 
    1610                 1615                 1620             


Asp Gly  Ser Pro Val Asn Val  Val Gln Leu Asn Phe  Leu Lys Leu 
    1625                 1630                 1635             


Leu Ser  Ala Thr Ala Arg Gln  Asn Phe Thr Tyr Ser  Cys Gln Asn 
    1640                 1645                 1650             


Ala Ala  Ala Trp Leu Asp Glu  Ala Thr Gly Asp Tyr  Ser His Ser 
    1655                 1660                 1665             


Ala Arg  Phe Leu Gly Thr Asn  Gly Glu Glu Leu Ser  Phe Asn Gln 
    1670                 1675                 1680             


Thr Thr  Ala Ala Thr Val Ser  Val Pro Gln Asp Gly  Cys Arg Leu 
    1685                 1690                 1695             


Arg Lys  Gly Gln Thr Lys Thr  Leu Phe Glu Phe Ser  Ser Ser Arg 
    1700                 1705                 1710             


Ala Gly  Phe Leu Pro Leu Trp  Asp Val Ala Ala Thr  Asp Phe Gly 
    1715                 1720                 1725             


Gln Thr  Asn Gln Lys Phe Gly  Phe Glu Leu Gly Pro  Val Cys Phe 
    1730                 1735                 1740             


Ser Ser  
    1745 


<210> 17
<211> 2704
<212> DNA
<213> Homo sapiens

<400> 17
ccgaacagga ttctttcacc caggcatctc ctccagaggg atccgccagc ccgtccagca       60

gcaccatgtg ggtgaccaaa ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc      120

tcctcctgct ccccatcgcc atcccctatg cagagggaca aaggaaaaga agaaatacaa      180

ttcatgaatt caaaaaatca gcaaagacta ccctaatcaa aatagatcca gcactgaaga      240

taaaaaccaa aaaagtgaat actgcagacc aatgtgctaa tagatgtact aggaataaag      300

gacttccatt cacttgcaag gcttttgttt ttgataaagc aagaaaacaa tgcctctggt      360

tccccttcaa tagcatgtca agtggagtga aaaaagaatt tggccatgaa tttgacctct      420

atgaaaacaa agactacatt agaaactgca tcattggtaa aggacgcagc tacaagggaa      480

cagtatctat cactaagagt ggcatcaaat gtcagccctg gagttccatg ataccacacg      540

aacacagctt tttgccttcg agctatcggg gtaaagacct acaggaaaac tactgtcgaa      600

atcctcgagg ggaagaaggg ggaccctggt gtttcacaag caatccagag gtacgctacg      660

aagtctgtga cattcctcag tgttcagaag ttgaatgcat gacctgcaat ggggagagtt      720

atcgaggtct catggatcat acagaatcag gcaagatttg tcagcgctgg gatcatcaga      780

caccacaccg gcacaaattc ttgcctgaaa gatatcccga caagggcttt gatgataatt      840

attgccgcaa tcccgatggc cagccgaggc catggtgcta tactcttgac cctcacaccc      900

gctgggagta ctgtgcaatt aaaacatgcg ctgacaatac tatgaatgac actgatgttc      960

ctttggaaac aactgaatgc atccaaggtc aaggagaagg ctacaggggc actgtcaata     1020

ccatttggaa tggaattcca tgtcagcgtt gggattctca gtatcctcac gagcatgaca     1080

tgactcctga aaatttcaag tgcaaggacc tacgagaaaa ttactgccga aatccagatg     1140

ggtctgaatc accctggtgt tttaccactg atccaaacat ccgagttggc tactgctccc     1200

aaattccaaa ctgtgatatg tcacatggac aagattgtta tcgtgggaat ggcaaaaatt     1260

atatgggcaa cttatcccaa acaagatctg gactaacatg ttcaatgtgg gacaagaaca     1320

tggaagactt acatcgtcat atcttctggg aaccagatgc aagtaagctg aatgagaatt     1380

actgccgaaa tccagatgat gatgctcatg gaccctggtg ctacacggga aatccactca     1440

ttccttggga ttattgccct atttctcgtt gtgaaggtga taccacacct acaatagtca     1500

atttagacca tcccgtaata tcttgtgcca aaacgaaaca attgcgagtt gtaaatggga     1560

ttccaacacg aacaaacata ggatggatgg ttagtttgag atacagaaat aaacatatct     1620

gcggaggatc attgataaag gagagttggg ttcttactgc acgacagtgt ttcccttctc     1680

gagacttgaa agattatgaa gcttggcttg gaattcatga tgtccacgga agaggagatg     1740

agaaatgcaa acaggttctc aatgtttccc agctggtata tggccctgaa ggatcagatc     1800

tggttttaat gaagcttgcc aggcctgctg tcctggatga ttttgttagt acgattgatt     1860

tacctaatta tggatgcaca attcctgaaa agaccagttg cagtgtttat ggctggggct     1920

acactggatt gatcaactat gatggcctat tacgagtggc acatctctat ataatgggaa     1980

atgagaaatg cagccagcat catcgaggga aggtgactct gaatgagtct gaaatatgtg     2040

ctggggctga aaagattgga tcaggaccat gtgaggggga ttatggtggc ccacttgttt     2100

gtgagcaaca taaaatgaga atggttcttg gtgtcattgt tcctggtcgt ggatgtgcca     2160

ttccaaatcg tcctggtatt tttgtccgag tagcatatta tgcaaaatgg atacacaaaa     2220

ttattttaac atataaggta ccacagtcat agctgaagta agtgtgtctg aagcacccac     2280

caatacaact gtcttttaca tgaagatttc agagaatgtg gaatttaaaa tgtcacttac     2340

aacaatccta agacaactac tggagagtca tgtttgttga aattctcatt aatgtttatg     2400

ggtgttttct gttgttttgt ttgtcagtgt tattttgtca atgttgaagt gaattaaggt     2460

acatgcaagt gtaataacat atctcctgaa gatacttgaa tggattaaaa aaacacacag     2520

gtatatttgc tggatgataa agatttcatg ggaaaaaaaa tcaattaatc tgtctaagct     2580

gctttctgat gttggtttct taataatgag taaaccacaa attaaatgtt attttaacct     2640

caccaaaaca atttatacct tgtgtcccta aattgtagcc ctatattaaa ttatattaca     2700

tttc                                                                  2704


<210> 18
<211> 728
<212> PRT
<213> Homo sapiens

<400> 18
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210> 19
<211> 6194
<212> DNA
<213> Homo sapiens

<400> 19
actaactcgc ggctgcagga tcagcgtctg gaagcagacg tttcggctac agacccagag       60

aggaggagct ggagatcagg aggcgtgagc cgccaagagt ttgcagaatc tgtggtgtga      120

atgaactggg ggcacctggg cgcacagatc gccccccttc ccccgccccg ggccacagtt      180

gagtagtggt acattttttt caccctcttg tgaagaattt ctttttatta ttatttgtcg      240

taaggtcttt tgcacaatca cgcccacatt tggggttgga aagccctaat taccgccgtc      300

gctgatggac gttggaaacg gagcgcctct ccgtggaaca gttgcctgcg cgccctcgcc      360

ggaccggcgg ctccctagtt gcgccccgac caggccctgc ccttgctgcc ggctcgcgcg      420

cgtccgcgcc ccctccattc ctgggcgcat cccagctctg ccccaactcg ggagtccagg      480

cccgggcgcc agtgcccgct tcagctccgg ttcactgcgc ccgccggacg cgcgccggag      540

gactccgcag ccctgctcct gaccgtcccc ccaggcttaa cccggtcgct ccgctcggat      600

tcctcggctg cgctcgctcg ggtggcgact tcctccccgc gccccctccc cctcgccatg      660

aagaagtcca ttggaatatt aagcccagga gttgctttgg ggatggctgg aagtgcaatg      720

tcttccaagt tcttcctagt ggctttggcc atatttttct ccttcgccca ggttgtaatt      780

gaagccaatt cttggtggtc gctaggtatg aataaccctg ttcagatgtc agaagtatat      840

attataggag cacagcctct ctgcagccaa ctggcaggac tttctcaagg acagaagaaa      900

ctgtgccact tgtatcagga ccacatgcag tacatcggag aaggcgcgaa gacaggcatc      960

aaagaatgcc agtatcaatt ccgacatcga aggtggaact gcagcactgt ggataacacc     1020

tctgtttttg gcagggtgat gcagataggc agccgcgaga cggccttcac atacgcggtg     1080

agcgcagcag gggtggtgaa cgccatgagc cgggcgtgcc gcgagggcga gctgtccacc     1140

tgcggctgca gccgcgccgc gcgccccaag gacctgccgc gggactggct ctggggcggc     1200

tgcggcgaca acatcgacta tggctaccgc tttgccaagg agttcgtgga cgcccgcgag     1260

cgggagcgca tccacgccaa gggctcctac gagagtgctc gcatcctcat gaacctgcac     1320

aacaacgagg ccggccgcag gacggtgtac aacctggctg atgtggcctg caagtgccat     1380

ggggtgtccg gctcatgtag cctgaagaca tgctggctgc agctggcaga cttccgcaag     1440

gtgggtgatg ccctgaagga gaagtacgac agcgcggcgg ccatgcggct caacagccgg     1500

ggcaagttgg tacaggtcaa cagccgcttc aactcgccca ccacacaaga cctggtctac     1560

atcgacccca gccctgacta ctgcgtgcgc aatgagagca ccggctcgct gggcacgcag     1620

ggccgcctgt gcaacaagac gtcggagggc atggatggct gcgagctcat gtgctgcggc     1680

cgtggctacg accagttcaa gaccgtgcag acggagcgct gccactgcaa gttccactgg     1740

tgctgctacg tcaagtgcaa gaagtgcacg gagatcgtgg accagtttgt gtgcaagtag     1800

tgggtgccac ccagcactca gccccgctcc caggacccgc ttatttatag aaagtacagt     1860

gattctggtt tttggttttt agaaatattt tttatttttc cccaagaatt gcaaccggaa     1920

ccattttttt tcctgttacc atctaagaac tctgtggttt attattaata ttataattat     1980

tatttggcaa taatgggggt gggaaccaag aaaaatattt attttgtgga tctttgaaaa     2040

ggtaatacaa gacttctttt gatagtatag aatgaagggg aaataacaca taccctaact     2100

tagctgtgtg gacatggtac acatccagaa ggtaaagaaa tacattttct ttttctcaaa     2160

tatgccatca tatgggatgg gtaggttcca gttgaaagag ggtggtagaa atctattcac     2220

aattcagctt ctatgaccaa aatgagttgt aaattctctg gtgcaagata aaaggtcttg     2280

ggaaaacaaa acaaaacaaa acaaacctcc cttccccagc agggctgcta gcttgctttc     2340

tgcattttca aaatgataat ttacaatgga aggacaagaa tgtcatattc tcaaggaaaa     2400

aaggtatatc acatgtctca ttctcctcaa atattccatt tgcagacaga ccgtcatatt     2460

ctaatagctc atgaaatttg ggcagcaggg aggaaagtcc ccagaaatta aaaaatttaa     2520

aactcttatg tcaagatgtt gatttgaagc tgttataaga attaggattc cagattgtaa     2580

aaagatcccc aaatgattct ggacactaga tttttttgtt tggggaggtt ggcttgaaca     2640

taaatgaaaa tatcctgtta ttttcttagg gatacttggt tagtaaatta taatagtaaa     2700

aataatacat gaatcccatt cacaggttct cagcccaagc aacaaggtaa ttgcgtgcca     2760

ttcagcactg caccagagca gacaacctat ttgaggaaaa acagtgaaat ccaccttcct     2820

cttcacactg agccctctct gattcctccg tgttgtgatg tgatgctggc cacgtttcca     2880

aacggcagct ccactgggtc ccctttggtt gtaggacagg aaatgaaaca ttaggagctc     2940

tgcttggaaa acagttcact acttagggat ttttgtttcc taaaactttt attttgagga     3000

gcagtagttt tctatgtttt aatgacagaa cttggctaat ggaattcaca gaggtgttgc     3060

agcgtatcac tgttatgatc ctgtgtttag attatccact catgcttctc ctattgtact     3120

gcaggtgtac cttaaaactg ttcccagtgt acttgaacag ttgcatttat aaggggggaa     3180

atgtggttta atggtgcctg atatctcaaa gtcttttgta cataacatat atatatatat     3240

acatatatat aaatataaat ataaatatat ctcattgcag ccagtgattt agatttacag     3300

tttactctgg ggttatttct ctgtctagag cattgttgtc cttcactgca gtccagttgg     3360

gattattcca aaagtttttt gagtcttgag cttgggctgt ggccctgctg tgatcatacc     3420

ttgagcacga cgaagcaacc ttgtttctga ggaagcttga gttctgactc actgaaatgc     3480

gtgttgggtt gaagatatct tttttctttt ctgcctcacc cctttgtctc caacctccat     3540

ttctgttcac tttgtggaga gggcattact tgttcgttat agacatggac gttaagagat     3600

attcaaaact cagaagcatc agcaatgttt ctcttttctt agttcattct gcagaatgga     3660

aacccatgcc tattagaaat gacagtactt attaattgag tccctaagga atattcagcc     3720

cactacatag atagcttttt tttttttttt tttaataagg acacctcttt ccaaacagtg     3780

ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa agatacacat     3840

ctttcatacc ccccttaggc aggttggctt tcatatcacc tcagccaact gtggctctta     3900

atttattgca taatgatatt cacatcccct cagttgcagt gaattgtgag caaaagatct     3960

tgaaagcaaa aagcactaat tagtttaaaa tgtcactttt ttggttttta ttatacaaaa     4020

accatgaagt acttttttta tttgctaaat cagattgttc ctttttagtg actcatgttt     4080

atgaagagag ttgagtttaa caatcctagc ttttaaaaga aactatttaa tgtaaaatat     4140

tctacatgtc attcagatat tatgtatatc ttctagcctt tattctgtac ttttaatgta     4200

catatttctg tcttgcgtga tttgtatatt tcactggttt aaaaaacaaa catcgaaagg     4260

cttatgccaa atggaagata gaatataaaa taaaacgtta cttgtatatt ggtaagtggt     4320

ttcaattgtc cttcagataa ttcatgtgga gatttttgga gaaaccatga cggatagttt     4380

aggatgacta catgtcaaag taataaaaga gtggtgaatt ttaccaaaac caagctattt     4440

ggaagcttca aaaggtttct atatgtaatg gaacaaaagg ggaattctct tttcctatat     4500

atgttcctta caaaaaaaaa aaaaaaagaa atcaagcaga tggcttaaag ctggttatag     4560

gattgctcac attcttttag cattatgcat gtaacttaat tgttttagag cgtgttgctg     4620

ttgtaacatc ccagagaaga atgaaaaggc acatgctttt atccgtgacc agatttttag     4680

tccaaaaaaa tgtatttttt tgtgtgttta ccactgcaac tattgcacct ctctatttga     4740

atttactgtg gaccatgtgt ggtgtctcta tgccctttga aagcagtttt tataaaaaga     4800

aagcccgggt ctgcagagaa tgaaaactgg ttggaaacta aaggttcatt gtgttaagtg     4860

caattaatac aagttattgt gcttttcaaa aatgtacacg gaaatctgga cagtgctcca     4920

cagattgata cattagcctt tgctttttct ctttccggat aaccttgtaa catattgaaa     4980

ccttttaagg atgccaagaa tgcattattc cacaaaaaaa cagcagacca acatatagag     5040

tgtttaaaat agcatttctg ggcaaattca aactcttgtg gttctaggac tcacatctgt     5100

ttcagttttt cctcagttgt atattgacca gtgttcttta ttgcaaaaac atatacccga     5160

tttagcagtg tcagcgtatt ttttcttctc atcctggagc gtattcaaga tcttcccaat     5220

acaagaaaat taataaaaaa tttatatata ggcagcagca aaagagccat gttcaaaata     5280

gtcattatgg gctcaaatag aaagaagact tttaagtttt aatccagttt atctgttgag     5340

ttctgtgagc tactgacctc ctgagactgg cactgtgtaa gttttagttg cctaccctag     5400

ctcttttctc gtacaatttt gccaatacca agtttcaatt tgtttttaca aaacattatt     5460

caagccacta gaattatcaa atatgacgct atagcagagt aaatactctg aataagagac     5520

cggtactagc taactccaag agatcgttag cagcatcagt ccacaaacac ttagtggccc     5580

acaatatata gagagataga aaaggtagtt ataacttgaa gcatgtattt aatgcaaata     5640

ggcacgaagg cacaggtcta aaatactaca ttgtcactgt aagctatact tttaaaatat     5700

ttattttttt taaagtattt tctagtcttt tctctctctg tggaatggtg aaagagagat     5760

gccgtgtttt gaaagtaaga tgatgaaatg aatttttaat tcaagaaaca ttcagaaaca     5820

taggaattaa aacttagaga aatgatctaa tttccctgtt cacacaaact ttacacttta     5880

atctgatgat tggatatttt attttagtga aacatcatct tgttagctaa ctttaaaaaa     5940

tggatgtaga atgattaaag gttggtatga ttttttttta atgtatcagt ttgaacctag     6000

aatattgaat taaaatgctg tctcagtatt ttaaaagcaa aaaaggaatg gaggaaaatt     6060

gcatcttaga ccatttttat atgcagtgta caatttgctg ggctagaaat gagataaaga     6120

ttatttattt ttgttcatat cttgtacttt tctattaaaa tcattttatg aaatccaaaa     6180

aaaaaaaaaa aaaa                                                       6194


<210> 20
<211> 380
<212> PRT
<213> Homo sapiens

<400> 20
Met Lys Lys Ser Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Met 
1               5                   10                  15      


Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala Ile 
            20                  25                  30          


Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp Ser 
        35                  40                  45              


Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
    50                  55                  60                  


Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
65                  70                  75                  80  


Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                85                  90                  95      


Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
            100                 105                 110         


Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
        115                 120                 125             


Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
    130                 135                 140                 


Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
145                 150                 155                 160 


Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg Asp 
                165                 170                 175     


Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe 
            180                 185                 190         


Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys 
        195                 200                 205             


Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu 
    210                 215                 220                 


Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys 
225                 230                 235                 240 


His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu 
                245                 250                 255     


Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser 
            260                 265                 270         


Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn 
        275                 280                 285             


Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro 
    290                 295                 300                 


Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu 
                325                 330                 335     


Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr 
            340                 345                 350         


Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys 
        355                 360                 365             


Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
    370                 375                 380 


<210> 21
<211> 760
<212> DNA
<213> Homo sapiens

<400> 21
gaggaaccga gaggctgaga ctaacccaga aacatccaat tctcaaactg aagctcgcac       60

tctcgcctcc agcatgaaag tctctgccgc ccttctgtgc ctgctgctca tagcagccac      120

cttcattccc caagggctcg ctcagccaga tgcaatcaat gccccagtca cctgctgtta      180

taacttcacc aataggaaga tctcagtgca gaggctcgcg agctatagaa gaatcaccag      240

cagcaagtgt cccaaagaag ctgtgatctt caagaccatt gtggccaagg agatctgtgc      300

tgaccccaag cagaagtggg ttcaggattc catggaccac ctggacaagc aaacccaaac      360

tccgaagact tgaacactca ctccacaacc caagaatctg cagctaactt attttcccct      420

agctttcccc agacaccctg ttttatttta ttataatgaa ttttgtttgt tgatgtgaaa      480

cattatgcct taagtaatgt taattcttat ttaagttatt gatgttttaa gtttatcttt      540

catggtacta gtgtttttta gatacagaga cttggggaaa ttgcttttcc tcttgaacca      600

cagttctacc cctgggatgt tttgagggtc tttgcaagaa tcattaatac aaagaatttt      660

ttttaacatt ccaatgcatt gctaaaatat tattgtggaa atgaatattt tgtaactatt      720

acaccaaata aatatatttt tgtacaaaaa aaaaaaaaaa                            760


<210> 22
<211> 99
<212> PRT
<213> Homo sapiens

<400> 22
Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210> 23
<211> 800
<212> DNA
<213> Homo sapiens

<400> 23
acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg       60

gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct      120

gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg      180

ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga      240

cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc      300

tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg      360

aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact      420

ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg      480

aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt      540

catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct      600

gggccacact gaccctgata caggcatggc agaagaatgg gaatatttta tactgacaga      660

aatcagtaat atttatatat ttatattttt aaaatattta tttatttatt tatttaagtt      720

catattccat atttattcaa gatgttttac cgtaataatt attattaaaa atatgcttct      780

acttgaaaaa aaaaaaaaaa                                                  800


<210> 24
<211> 144
<212> PRT
<213> Homo sapiens

<400> 24
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 25
<211> 2358
<212> DNA
<213> Homo sapiens

<400> 25
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca       60

gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc      120

ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc      180

cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg      240

ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc      300

cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg      360

acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg      420

acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga      480

tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca      540

gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg      600

gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga      660

ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc      720

aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc      780

caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga      840

cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga      900

agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga      960

agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg     1020

gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat     1080

gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg     1140

tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag     1200

acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc     1260

agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt     1320

ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa     1380

gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac     1440

actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat     1500

gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat     1560

cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat     1620

tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag     1680

ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat     1740

tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt     1800

ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg     1860

tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg     1920

tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct     1980

gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta     2040

tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga     2100

ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa     2160

tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc     2220

tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt     2280

gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta     2340

taaaaaaaaa aaaaaaaa                                                   2358


<210> 26
<211> 349
<212> PRT
<213> Homo sapiens

<400> 26
Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210> 27
<211> 1574
<212> DNA
<213> Homo sapiens

<400> 27
tcaccacggc ggcagccctt taaacccctc acccagccag cgccccatcc tgtctgtccg       60

aacccagaca caagtcttca ctccttcctg cgagccctga ggaagccttg tgagtgcatt      120

ggctggggct tggagggaag ttgggctgga gctggacagg agcagtgggt gcatttcagg      180

caggctctcc tgaggtccca ggcgccagct ccagctccct ggctagggaa acccaccctc      240

tcagtcagca tgggggccca agctccaggc agggtgggct ggatcactag cgtcctggat      300

ctctctcaga ctgggcagcc ccgggctcat tgaaatgccc cggatgactt ggctagtgca      360

gaggaattga tggaaaccac cggggtgaga gggaggctcc ccatctcagc cagccacatc      420

cacaaggtgt gtgtaagggt gcaggcgccg gccggttagg ccaaggctct actgtctgtt      480

gcccctccag gagaacttcc aaggagcttt ccccagacat ggccaacaag ggtccttcct      540

atggcatgag ccgcgaagtg cagtccaaaa tcgagaagaa gtatgacgag gagctggagg      600

agcggctggt ggagtggatc atagtgcagt gtggccctga tgtgggccgc ccagaccgtg      660

ggcgcttggg cttccaggtc tggctgaaga atggcgtgat tctgagcaag ctggtgaaca      720

gcctgtaccc tgatggctcc aagccggtga aggtgcccga gaacccaccc tccatggtct      780

tcaagcagat ggagcaggtg gctcagttcc tgaaggcggc tgaggactat ggggtcatca      840

agactgacat gttccagact gttgacctct ttgaaggcaa agacatggca gcagtgcaga      900

ggaccctgat ggctttgggc agcttggcag tgaccaagaa tgatgggcac taccgtggag      960

atcccaactg gtttatgaag aaagcgcagg agcataagag ggaattcaca gagagccagc     1020

tgcaggaggg aaagcatgtc attggccttc agatgggcag caacagaggg gcctcccagg     1080

ccggcatgac aggctacgga cgacctcggc agatcatcag ttagagcgga gagggctagc     1140

cctgagcccg gccctccccc agctccttgg ctgcagccat cccgcttagc ctgcctcacc     1200

cacacccgtg tggtaccttc agccctggcc aagctttgag gctctgtcac tgagcaatgg     1260

taactgcacc tgggcagctc ctccctgtgc ccccagcctc agcccaactt cttacccgaa     1320

agcatcactg ccttggcccc tccctcccgg ctgcccccat cacctctact gtctcctccc     1380

tgggctaagc aggggagaag cgggctgggg gtagcctgga tgtgggccaa gtccactgtc     1440

ctccttggcg gcaaaagccc attgaagaag aaccagccca gcctgccccc tatcttgtcc     1500

tggaatattt ttggggttgg aactcaaaaa aaaaaaaaaa aaatcaatct tttctcaaaa     1560

aaaaaaaaaa aaaa                                                       1574


<210> 28
<211> 199
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Asn Lys Gly Pro Ser Tyr Gly Met Ser Arg Glu Val Gln Ser 
1               5                   10                  15      


Lys Ile Glu Lys Lys Tyr Asp Glu Glu Leu Glu Glu Arg Leu Val Glu 
            20                  25                  30          


Trp Ile Ile Val Gln Cys Gly Pro Asp Val Gly Arg Pro Asp Arg Gly 
        35                  40                  45              


Arg Leu Gly Phe Gln Val Trp Leu Lys Asn Gly Val Ile Leu Ser Lys 
    50                  55                  60                  


Leu Val Asn Ser Leu Tyr Pro Asp Gly Ser Lys Pro Val Lys Val Pro 
65                  70                  75                  80  


Glu Asn Pro Pro Ser Met Val Phe Lys Gln Met Glu Gln Val Ala Gln 
                85                  90                  95      


Phe Leu Lys Ala Ala Glu Asp Tyr Gly Val Ile Lys Thr Asp Met Phe 
            100                 105                 110         


Gln Thr Val Asp Leu Phe Glu Gly Lys Asp Met Ala Ala Val Gln Arg 
        115                 120                 125             


Thr Leu Met Ala Leu Gly Ser Leu Ala Val Thr Lys Asn Asp Gly His 
    130                 135                 140                 


Tyr Arg Gly Asp Pro Asn Trp Phe Met Lys Lys Ala Gln Glu His Lys 
145                 150                 155                 160 


Arg Glu Phe Thr Glu Ser Gln Leu Gln Glu Gly Lys His Val Ile Gly 
                165                 170                 175     


Leu Gln Met Gly Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr Gly 
            180                 185                 190         


Arg Pro Arg Gln Ile Ile Ser 
        195                 


