                         SEQUENCE LISTING

<110>  Kaplitt, Michael
       Andersen, Dan
      
 
<120>  OPTOGENETIC THERAPIES FOR MOVEMENT DISORDERS

<130>  9511-20041.00 US

<150>  US 62/010967
<151>  2014-06-11

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  1

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  2
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  2

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ala 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  3
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  3

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ser 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  4
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  4

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Thr 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  5
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  5

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Ala Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  6
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  6

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ser 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Ala Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  7
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  7

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Cys Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  8
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  8

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Cys Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  9
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  9

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Thr Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Cys Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  10
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  10

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  11
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  11

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Ala Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  12
<211>  310
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  12

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Thr Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  13
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  14
<211>  285
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys 
1               5                   10                  15      


Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala 
            20                  25                  30          


Asn Ile Leu Gln Trp Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met 
        35                  40                  45              


Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly Trp Glu Thr Ile 
    50                  55                  60                  


Tyr Val Ala Thr Ile Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His 
65                  70                  75                  80  


Glu Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr 
                85                  90                  95      


Val Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Leu Leu 
            100                 105                 110         


Ile His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg 
        115                 120                 125             


Thr Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala 
    130                 135                 140                 


Thr Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile 
145                 150                 155                 160 


Ser Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr 
                165                 170                 175     


Ile Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val 
            180                 185                 190         


Arg Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val 
        195                 200                 205             


Leu Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly 
    210                 215                 220                 


Ser Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp 
225                 230                 235                 240 


Gly Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu 
                245                 250                 255     


Leu Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln 
            260                 265                 270         


Glu Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
        275                 280                 285 


<210>  15
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Thr Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  16
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Thr Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Thr Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  17
<211>  357
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg Tyr 
145                 150                 155                 160 


Gly Thr Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Ala Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp Asp Thr Val Lys Gln Ser Thr Ala 
            340                 345                 350         


Lys Tyr Ala Ser Arg 
        355         


<210>  18
<211>  361
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Thr Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg Tyr 
145                 150                 155                 160 


Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Ala Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp Asp Thr Val Lys Gln Ser Asn Pro 
            340                 345                 350         


His Arg Thr Ala Lys Tyr Ala Ser Arg 
        355                 360     


<210>  19
<211>  357
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Thr Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg Tyr 
145                 150                 155                 160 


Gly Thr Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Ala Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp Asp Thr Val Lys Gln Ser Thr Ala 
            340                 345                 350         


Lys Tyr Ala Ser Arg 
        355         


<210>  20
<211>  300
<212>  PRT
<213>  Volvox carteri

<400>  20

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  21
<211>  300
<212>  PRT
<213>  Volvox carteri

<400>  21

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Ser Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  22
<211>  300
<212>  PRT
<213>  Volvox carteri

<400>  22

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Ser Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Ala Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  23
<211>  350
<212>  PRT
<213>  Chlamydomonas rheinhardtii

<400>  23

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp Tyr Ala Tyr 
            100                 105                 110         


Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Ala Leu 
        115                 120                 125             


Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu Phe Asp Ser 
    130                 135                 140                 


Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg 
145                 150                 155                 160 


Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
        195                 200                 205             


Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr 
    210                 215                 220                 


Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg Ala Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly 
        275                 280                 285             


His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly 
    290                 295                 300                 


Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val 
                325                 330                 335     


Glu Thr Leu Val Ala Glu Glu Glu Asp Lys Tyr Glu Ser Ser 
            340                 345                 350 


<210>  24
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp Tyr Ala Tyr 
            100                 105                 110         


Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Ala Leu 
        115                 120                 125             


Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu Phe Asp Ser 
    130                 135                 140                 


Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg 
145                 150                 155                 160 


Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
        195                 200                 205             


Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr 
    210                 215                 220                 


Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg Ala Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly 
        275                 280                 285             


His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly 
    290                 295                 300                 


Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val 
                325                 330                 335     


Glu Thr Leu Val Ala Glu Glu Glu Asp Lys Tyr Glu Ser Ser 
            340                 345                 350 


<210>  25
<211>  258
<212>  PRT
<213>  Halorubrum sodomense

<400>  25

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp 
        


<210>  26
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Ile Val Lys Gly Trp Gly Val Thr Asp Lys Glu 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ser Ile Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Ala Gly Glu Val Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Ser Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Pro Leu Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ala Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro 
                245             


<210>  27
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp Arg Pro Val Val Ala Val Ser Lys Ala Ala Ala Lys Ser Arg 
            260                 265                 270         


Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn 
        275                 280                 285             


Val Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    290                 295                 300                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
305                 310                 315                 320 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                325                 330                 335     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            340                 345                 350         


Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
        355                 360                 365             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
    370                 375                 380                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
385                 390                 395                 400 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                405                 410                 415     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            420                 425                 430         


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
        435                 440                 445             


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
    450                 455                 460                 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
465                 470                 475                 480 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
                485                 490                 495     


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
            500                 505                 510         


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Phe 
        515                 520                 525             


Cys Tyr Glu Asn Glu Val 
    530                 


<210>  28
<211>  313
<212>  PRT
<213>  Leptosphaeria maculans

<400>  28

Met Ile Val Asp Gln Phe Glu Glu Val Leu Met Lys Thr Ser Gln Leu 
1               5                   10                  15      


Phe Pro Leu Pro Thr Ala Thr Gln Ser Ala Gln Pro Thr His Val Ala 
            20                  25                  30          


Pro Val Pro Thr Val Leu Pro Asp Thr Pro Ile Tyr Glu Thr Val Gly 
        35                  40                  45              


Asp Ser Gly Ser Lys Thr Leu Trp Val Val Phe Val Leu Met Leu Ile 
    50                  55                  60                  


Ala Ser Ala Ala Phe Thr Ala Leu Ser Trp Lys Ile Pro Val Asn Arg 
65                  70                  75                  80  


Arg Leu Tyr His Val Ile Thr Thr Ile Ile Thr Leu Thr Ala Ala Leu 
                85                  90                  95      


Ser Tyr Phe Ala Met Ala Thr Gly His Gly Val Ala Leu Asn Lys Ile 
            100                 105                 110         


Val Ile Arg Thr Gln His Asp His Val Pro Asp Thr Tyr Glu Thr Val 
        115                 120                 125             


Tyr Arg Gln Val Tyr Tyr Ala Arg Tyr Ile Asp Trp Ala Ile Thr Thr 
    130                 135                 140                 


Pro Leu Leu Leu Leu Asp Leu Gly Leu Leu Ala Gly Met Ser Gly Ala 
145                 150                 155                 160 


His Ile Phe Met Ala Ile Val Ala Asp Leu Ile Met Val Leu Thr Gly 
                165                 170                 175     


Leu Phe Ala Ala Phe Gly Ser Glu Gly Thr Pro Gln Lys Trp Gly Trp 
            180                 185                 190         


Tyr Thr Ile Ala Cys Ile Ala Tyr Ile Phe Val Val Trp His Leu Val 
        195                 200                 205             


Leu Asn Gly Gly Ala Asn Ala Arg Val Lys Gly Glu Lys Leu Arg Ser 
    210                 215                 220                 


Phe Phe Val Ala Ile Gly Ala Tyr Thr Leu Ile Leu Trp Thr Ala Tyr 
225                 230                 235                 240 


Pro Ile Val Trp Gly Leu Ala Asp Gly Ala Arg Lys Ile Gly Val Asp 
                245                 250                 255     


Gly Glu Ile Ile Ala Tyr Ala Val Leu Asp Val Leu Ala Lys Gly Val 
            260                 265                 270         


Phe Gly Ala Trp Leu Leu Val Thr His Ala Asn Leu Arg Glu Ser Asp 
        275                 280                 285             


Val Glu Leu Asn Gly Phe Trp Ala Asn Gly Leu Asn Arg Glu Gly Ala 
    290                 295                 300                 


Ile Arg Ile Gly Glu Asp Asp Gly Ala 
305                 310             


<210>  29
<211>  262
<212>  PRT
<213>  Halobacterium salinarum

<400>  29

Met Leu Glu Leu Leu Pro Thr Ala Val Glu Gly Val Ser Gln Ala Gln 
1               5                   10                  15      


Ile Thr Gly Arg Pro Glu Trp Ile Trp Leu Ala Leu Gly Thr Ala Leu 
            20                  25                  30          


Met Gly Leu Gly Thr Leu Tyr Phe Leu Val Lys Gly Met Gly Val Ser 
        35                  40                  45              


Asp Pro Asp Ala Lys Lys Phe Tyr Ala Ile Thr Thr Leu Val Pro Ala 
    50                  55                  60                  


Ile Ala Phe Thr Met Tyr Leu Ser Met Leu Leu Gly Tyr Gly Leu Thr 
65                  70                  75                  80  


Met Val Pro Phe Gly Gly Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr 
                85                  90                  95      


Ala Asp Trp Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu 
            100                 105                 110         


Leu Val Asp Ala Asp Gln Gly Thr Ile Leu Ala Leu Val Gly Ala Asp 
        115                 120                 125             


Gly Ile Met Ile Gly Thr Gly Leu Val Gly Ala Leu Thr Lys Val Tyr 
    130                 135                 140                 


Ser Tyr Arg Phe Val Trp Trp Ala Ile Ser Thr Ala Ala Met Leu Tyr 
145                 150                 155                 160 


Ile Leu Tyr Val Leu Phe Phe Gly Phe Thr Ser Lys Ala Glu Ser Met 
                165                 170                 175     


Arg Pro Glu Val Ala Ser Thr Phe Lys Val Leu Arg Asn Val Thr Val 
            180                 185                 190         


Val Leu Trp Ser Ala Tyr Pro Val Val Trp Leu Ile Gly Ser Glu Gly 
        195                 200                 205             


Ala Gly Ile Val Pro Leu Asn Ile Glu Thr Leu Leu Phe Met Val Leu 
    210                 215                 220                 


Asp Val Ser Ala Lys Val Gly Phe Gly Leu Ile Leu Leu Arg Ser Arg 
225                 230                 235                 240 


Ala Ile Phe Gly Glu Ala Glu Ala Pro Glu Pro Ser Ala Gly Asp Gly 
                245                 250                 255     


Ala Ala Ala Thr Ser Asp 
            260         


<210>  30
<211>  365
<212>  PRT
<213>  Dunaliella salina

<400>  30

Met Arg Arg Arg Glu Ser Gln Leu Ala Tyr Leu Cys Leu Phe Val Leu 
1               5                   10                  15      


Ile Ala Gly Trp Ala Pro Arg Leu Thr Glu Ser Ala Pro Asp Leu Ala 
            20                  25                  30          


Glu Arg Arg Pro Pro Ser Glu Arg Asn Thr Pro Tyr Ala Asn Ile Lys 
        35                  40                  45              


Lys Val Pro Asn Ile Thr Glu Pro Asn Ala Asn Val Gln Leu Asp Gly 
    50                  55                  60                  


Trp Ala Leu Tyr Gln Asp Phe Tyr Tyr Leu Ala Gly Ser Asp Lys Glu 
65                  70                  75                  80  


Trp Val Val Gly Pro Ser Asp Gln Cys Tyr Cys Arg Ala Trp Ser Lys 
                85                  90                  95      


Ser His Gly Thr Asp Arg Glu Gly Glu Ala Ala Val Val Trp Ala Tyr 
            100                 105                 110         


Ile Val Phe Ala Ile Cys Ile Val Gln Leu Val Tyr Phe Met Phe Ala 
        115                 120                 125             


Ala Trp Lys Ala Thr Val Gly Trp Glu Glu Val Tyr Val Asn Ile Ile 
    130                 135                 140                 


Glu Leu Val His Ile Ala Leu Val Ile Trp Val Glu Phe Asp Lys Pro 
145                 150                 155                 160 


Ala Met Leu Tyr Leu Asn Asp Gly Gln Met Val Pro Trp Leu Arg Tyr 
                165                 170                 175     


Ser Ala Trp Leu Leu Ser Cys Pro Val Ile Leu Ile His Leu Ser Asn 
            180                 185                 190         


Leu Thr Gly Leu Lys Gly Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
        195                 200                 205             


Val Ser Asp Ile Gly Thr Ile Val Phe Gly Thr Ser Ala Ala Leu Ala 
    210                 215                 220                 


Pro Pro Asn His Val Lys Val Ile Leu Phe Thr Ile Gly Leu Leu Tyr 
225                 230                 235                 240 


Gly Leu Phe Thr Phe Phe Thr Ala Ala Lys Val Tyr Ile Glu Ala Tyr 
                245                 250                 255     


His Thr Val Pro Lys Gly Gln Cys Arg Asn Leu Val Arg Ala Met Ala 
            260                 265                 270         


Trp Thr Tyr Phe Val Ser Trp Ala Met Phe Pro Ile Leu Phe Ile Leu 
        275                 280                 285             


Gly Arg Glu Gly Phe Gly His Ile Thr Tyr Phe Gly Ser Ser Ile Gly 
    290                 295                 300                 


His Phe Ile Leu Glu Ile Phe Ser Lys Asn Leu Trp Ser Leu Leu Gly 
305                 310                 315                 320 


His Gly Leu Arg Tyr Arg Ile Arg Gln His Ile Ile Ile His Gly Asn 
                325                 330                 335     


Leu Thr Lys Lys Asn Lys Ile Asn Ile Ala Gly Asp Asn Val Glu Val 
            340                 345                 350         


Glu Glu Tyr Val Asp Ser Asn Asp Lys Asp Ser Asp Val 
        355                 360                 365 


<210>  31
<211>  270
<212>  PRT
<213>  Guillardia theta

<400>  31

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Ser Ser Phe Gly Lys Ala Leu Leu Glu Phe Val Phe Ile Val Phe Ala 
    50                  55                  60                  


Cys Ile Thr Leu Leu Leu Gly Ile Asn Ala Ala Lys Ser Lys Ala Ala 
65                  70                  75                  80  


Ser Arg Val Leu Phe Pro Ala Thr Phe Val Thr Gly Ile Ala Ser Ile 
                85                  90                  95      


Ala Tyr Phe Ser Met Ala Ser Gly Gly Gly Trp Val Ile Ala Pro Asp 
            100                 105                 110         


Cys Arg Gln Leu Phe Val Ala Arg Tyr Leu Asp Trp Leu Ile Thr Thr 
        115                 120                 125             


Pro Leu Leu Leu Ile Asp Leu Gly Leu Val Ala Gly Val Ser Arg Trp 
    130                 135                 140                 


Asp Ile Met Ala Leu Cys Leu Ser Asp Val Leu Met Ile Ala Thr Gly 
145                 150                 155                 160 


Ala Phe Gly Ser Leu Thr Val Gly Asn Val Lys Trp Val Trp Trp Phe 
                165                 170                 175     


Phe Gly Met Cys Trp Phe Leu His Ile Ile Phe Ala Leu Gly Lys Ser 
            180                 185                 190         


Trp Ala Glu Ala Ala Lys Ala Lys Gly Gly Asp Ser Ala Ser Val Tyr 
        195                 200                 205             


Ser Lys Ile Ala Gly Ile Thr Val Ile Thr Trp Phe Cys Tyr Pro Val 
    210                 215                 220                 


Val Trp Val Phe Ala Glu Gly Phe Gly Asn Phe Ser Val Thr Phe Glu 
225                 230                 235                 240 


Val Leu Ile Tyr Gly Val Leu Asp Val Ile Ser Lys Ala Val Phe Gly 
                245                 250                 255     


Leu Ile Leu Met Ser Gly Ala Ala Thr Gly Tyr Glu Ser Ile 
            260                 265                 270 


<210>  32
<211>  291
<212>  PRT
<213>  Natromonas pharaonis

<400>  32

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro 
            20                  25                  30          


Leu Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser 
        35                  40                  45              


Ile Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala 
    50                  55                  60                  


Lys Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala 
65                  70                  75                  80  


Ser Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met 
                85                  90                  95      


Pro Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu 
            100                 105                 110         


Glu Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala 
        115                 120                 125             


Leu Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser 
    130                 135                 140                 


Asn Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys 
145                 150                 155                 160 


Val Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg 
                165                 170                 175     


Trp Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr 
            180                 185                 190         


Ile Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala 
        195                 200                 205             


Asp Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly 
    210                 215                 220                 


Tyr Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro 
225                 230                 235                 240 


Val Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys 
                245                 250                 255     


Tyr Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser 
            260                 265                 270         


Val Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro 
        275                 280                 285             


Ala Asp Asp 
    290     


<210>  33
<211>  559
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro 
            20                  25                  30          


Leu Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser 
        35                  40                  45              


Ile Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala 
    50                  55                  60                  


Lys Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala 
65                  70                  75                  80  


Ser Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met 
                85                  90                  95      


Pro Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu 
            100                 105                 110         


Glu Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala 
        115                 120                 125             


Leu Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser 
    130                 135                 140                 


Asn Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys 
145                 150                 155                 160 


Val Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg 
                165                 170                 175     


Trp Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr 
            180                 185                 190         


Ile Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala 
        195                 200                 205             


Asp Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly 
    210                 215                 220                 


Tyr Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro 
225                 230                 235                 240 


Val Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys 
                245                 250                 255     


Tyr Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser 
            260                 265                 270         


Val Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro 
        275                 280                 285             


Ala Asp Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr 
    290                 295                 300                 


Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Val Ser Lys Gly Glu Glu 
305                 310                 315                 320 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
                325                 330                 335     


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
            340                 345                 350         


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
        355                 360                 365             


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys 
    370                 375                 380                 


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
385                 390                 395                 400 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
                405                 410                 415     


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
            420                 425                 430         


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
        435                 440                 445             


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
    450                 455                 460                 


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
465                 470                 475                 480 


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
                485                 490                 495     


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
            500                 505                 510         


His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
        515                 520                 525             


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
    530                 535                 540                 


Leu Gly Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
545                 550                 555                 


<210>  34
<211>  542
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro Leu 
1               5                   10                  15      


Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser Ile 
            20                  25                  30          


Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala Lys 
        35                  40                  45              


Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala Ser 
    50                  55                  60                  


Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met Pro 
65                  70                  75                  80  


Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu Glu 
                85                  90                  95      


Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala Leu 
            100                 105                 110         


Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser Asn 
        115                 120                 125             


Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys Val 
    130                 135                 140                 


Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg Trp 
145                 150                 155                 160 


Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr Ile 
                165                 170                 175     


Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala Asp 
            180                 185                 190         


Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly Tyr 
        195                 200                 205             


Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro Val 
    210                 215                 220                 


Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys Tyr 
225                 230                 235                 240 


Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser Val 
                245                 250                 255     


Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro Ala 
            260                 265                 270         


Asp Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile 
        275                 280                 285             


Pro Leu Asp Gln Ile Asp Ile Asn Val Val Ser Lys Gly Glu Glu Leu 
    290                 295                 300                 


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
305                 310                 315                 320 


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
                325                 330                 335     


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
            340                 345                 350         


Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe 
        355                 360                 365             


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
    370                 375                 380                 


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
385                 390                 395                 400 


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                405                 410                 415     


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
            420                 425                 430         


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
        435                 440                 445             


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
    450                 455                 460                 


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
465                 470                 475                 480 


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
                485                 490                 495     


Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
            500                 505                 510         


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
        515                 520                 525             


Gly Met Asp Glu Leu Tyr Lys Phe Cys Tyr Glu Asn Glu Val 
    530                 535                 540         


<210>  35
<211>  434
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Lys 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Ala Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Met Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Ile Ala Lys 
    50                  55                  60                  


Phe Glu Arg Leu Gln Thr Val Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Phe Gly Gly Phe Thr Thr Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Thr Ser Pro Phe Lys 
    130                 135                 140                 


Tyr Gln Ser Leu Leu Thr Lys Asn Lys Ala Ile Met Gly Val Ala Phe 
145                 150                 155                 160 


Thr Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Val Gly Trp 
                165                 170                 175     


Ser Arg Tyr Ile Pro Glu Gly Met Gln Cys Ser Cys Gly Ile Asp Tyr 
            180                 185                 190         


Tyr Thr Pro His Glu Glu Thr Asn Asn Glu Ser Phe Val Ile Tyr Met 
        195                 200                 205             


Phe Val Val His Phe Ile Ile Pro Leu Ile Val Ile Phe Phe Cys Tyr 
    210                 215                 220                 


Gly Arg Val Phe Gln Val Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys 
225                 230                 235                 240 


Ser Glu Gly Arg Phe His Ser Pro Asn Leu Gly Gln Val Glu Gln Asp 
                245                 250                 255     


Gly Arg Ser Gly His Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys 
            260                 265                 270         


Glu His Lys Ala Leu Arg Met Val Ile Ile Met Val Ile Ala Phe Leu 
        275                 280                 285             


Ile Cys Trp Leu Pro Tyr Ala Gly Val Ala Phe Tyr Ile Phe Thr His 
    290                 295                 300                 


Gln Gly Ser Asp Phe Gly Pro Ile Phe Met Thr Ile Pro Ala Phe Phe 
305                 310                 315                 320 


Ala Lys Thr Ser Ala Val Tyr Asn Pro Val Ile Tyr Ile Met Met Asn 
                325                 330                 335     


Lys Gln Phe Arg Ile Ala Phe Gln Glu Leu Leu Cys Leu Arg Arg Ser 
            340                 345                 350         


Ser Ser Lys Ala Tyr Gly Asn Gly Tyr Ser Ser Asn Ser Asn Gly Lys 
        355                 360                 365             


Thr Asp Tyr Met Gly Glu Ala Ser Gly Cys Gln Leu Gly Gln Glu Lys 
    370                 375                 380                 


Glu Ser Glu Arg Leu Cys Glu Asp Pro Pro Gly Thr Glu Ser Phe Val 
385                 390                 395                 400 


Asn Cys Gln Gly Thr Val Pro Ser Leu Ser Leu Asp Ser Gln Gly Arg 
                405                 410                 415     


Asn Cys Ser Thr Asn Asp Ser Pro Leu Thr Glu Thr Ser Gln Val Ala 
            420                 425                 430         


Pro Ala 
        


<210>  36
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Lys 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Ala Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Met Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Val Ala Cys 
    50                  55                  60                  


His Arg His Leu His Ser Val Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Phe Gly Gly Phe Thr Thr Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Ser Tyr Pro Leu Arg 
    130                 135                 140                 


Tyr Pro Thr Ile Val Thr Gln Arg Arg Ala Ile Met Gly Val Ala Phe 
145                 150                 155                 160 


Thr Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Val Gly Trp 
                165                 170                 175     


Ser Arg Tyr Ile Pro Glu Gly Met Gln Cys Ser Cys Gly Ile Asp Tyr 
            180                 185                 190         


Tyr Thr Pro His Glu Glu Thr Asn Asn Glu Ser Phe Val Ile Tyr Met 
        195                 200                 205             


Phe Val Val His Phe Ile Ile Pro Leu Ile Val Ile Phe Phe Cys Tyr 
    210                 215                 220                 


Gly Arg Val Tyr Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser 
225                 230                 235                 240 


Gly Leu Lys Thr Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile 
                245                 250                 255     


His Arg Lys Asn Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys 
            260                 265                 270         


Thr Lys Thr His Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys 
        275                 280                 285             


Lys Ala Ala Arg Met Val Ile Ile Met Val Ile Ala Phe Leu Ile Cys 
    290                 295                 300                 


Trp Leu Pro Tyr Ala Gly Val Ala Phe Tyr Ile Phe Thr His Gln Gly 
305                 310                 315                 320 


Ser Asp Phe Gly Pro Ile Phe Met Thr Ile Pro Ala Phe Phe Ala Lys 
                325                 330                 335     


Thr Ser Ala Val Tyr Asn Pro Val Ile Tyr Ile Met Met Asn Lys Gln 
            340                 345                 350         


Phe Arg Lys Ala Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg 
        355                 360                 365             


Lys Gln Ser Ser Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser 
    370                 375                 380                 


Gln Ala Val Glu Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly 
385                 390                 395                 400 


Ser Arg Glu Thr Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu 
                405                 410                 415     


Trp Lys Phe Phe Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val 
            420                 425                 430         


Ser Lys Asp Gln Ser Ser Cys Thr Thr Ala Arg Val Arg Ser Lys Ser 
        435                 440                 445             


Phe Leu Gln Val Cys Cys Cys Val Gly Pro Ser Thr Pro Ser Leu Asp 
    450                 455                 460                 


Lys Asn His Gln Val Pro Thr Ile Lys Val His Thr Ile Ser Leu Ser 
465                 470                 475                 480 


Glu Asn Gly Glu Glu Val Thr Glu Thr Ser Gln Val Ala Pro Ala 
                485                 490                 495 


<210>  37
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
1               5                   10                  15      


Asp Ile Asn Val 
            20  


<210>  38
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser 
            20                  25      


<210>  39
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Ala Gly His Ser Asn Ser Met Ala Leu Phe Ser Phe Ser Leu Leu 
1               5                   10                  15      


Trp Leu Cys Ser Gly Val Leu Gly Thr Glu Phe 
            20                  25          


<210>  40
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly 
            20              


<210>  41
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Arg Gly Thr Pro Leu Leu Leu Val Val Ser Leu Phe Ser Leu Leu 
1               5                   10                  15      


Gln Asp 
        


<210>  42
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Val Xaa Xaa Ser Leu 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Val Lys Glu Ser Leu 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Val Leu Gly Ser Leu 
1               5   


<210>  45
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser Lys 
1               5                   10                  15      


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Phe Xaa Tyr Glu Asn Glu 
1               5       


<210>  47
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Phe Cys Tyr Glu Asn Glu Val 
1               5           


<210>  48
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu 
        


<210>  49
<211>  357
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg Tyr 
145                 150                 155                 160 


Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Ala Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp Asp Thr Val Lys Gln Ser Thr Ala 
            340                 345                 350         


Lys Tyr Ala Ser Arg 
        355         


<210>  50
<211>  7811
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtgtgtc tagactgcag agggccctgc      180

gtatgagtgc aagtgggttt taggaccagg atgaggcggg gtgggggtgc ctacctgacg      240

accgaccccg acccactgga caagcaccca acccccattc cccaaattgc gcatccccta      300

tcagagaggg ggaggggaaa caggatgcgg cgaggcgcgt gcgcactgcc agcttcagca      360

ccgcggacag tgccttcgcc cccgcctggc ggcgcgcgcc accgccgcct cagcactgaa      420

ggcgcgctga cgtcactcgc cggtcccccg caaactcccc ttcccggcca ccttggtcgc      480

gtccgcgccg ccgccggccc agccggaccg caccacgcga ggcgcgagat aggggggcac      540

gggcgcgacc atctgcgctg cggcgccggc gactcagcgc tgcctcagtc tgcggtgggc      600

agcggaggag tcgtgtcgtg cctgagagcg cagtcgagaa ggtaccggat ccgccaccat      660

ggaccccatc gctctgcagg ctggttacga cctgctgggt gacggcagac ctgaaactct      720

gtggctgggc atcggcactc tgctgatgct gattggaacc ttctactttc tggtccgcgg      780

atggggagtc accgataagg atgcccggga atattacgct gtgactatcc tggtgcccgg      840

aatcgcatcc gccgcatatc tgtctatgtt ctttggtatc gggcttactg aggtgaccgt      900

cgggggcgaa atgttggata tctattatgc caggtacgcc gactggctgt ttaccacccc      960

acttctgctg ctggatctgg cccttctcgc taaggtggat cgggtgacca tcggcaccct     1020

ggtgggtgtg gacgccctga tgatcgtcac tggcctcatc ggagccttga gccacacggc     1080

catagccaga tacagttggt ggttgttctc tacaatttgc atgatagtgg tgctctattt     1140

tctggctaca tccctgcgat ctgctgcaaa ggagcggggc cccgaggtgg catctacctt     1200

taacaccctg acagctctgg tcttggtgct gtggaccgct taccctatcc tgtggatcat     1260

aggcactgag ggcgctggcg tggtgggcct gggcatcgaa actctgctgt ttatggtgtt     1320

ggacgtgact gccaaggtcg gctttggctt tatcctgttg agatcccggg ctattctggg     1380

cgacaccgag gcaccagaac ccagtgccgg tgccgatgtc agtgccgccg acaagagcag     1440

gatcaccagc gagggcgagt acatccccct ggaccagatc gacatcaacg tgggcgcgcc     1500

cggctccgga gccacgaact tctctctgtt aaagcaagca ggagacgtgg aagaaaaccc     1560

cggtcccatg gacctgaagg agtcaccaag cgagggatca ctgcagccat caagcattca     1620

gattttcgct aatacaagca cactgcacgg catccggcat atcttcgtgt acggcccact     1680

gaccattcgg agagtcctgt gggcagtggc ctttgtcgga agcctgggac tgctgctggt     1740

ggagagctcc gaaagagtca gttactattt ctcatatcag cacgtgacta aggtggacga     1800

ggtggtcgct cagtccctgg tgtttcccgc agtcaccctg tgcaacctga atgggttcag     1860

gttttctcgc ctgaccacaa acgacctgta ccacgccgga gagctgctgg ctctgctgga     1920

tgtgaatctg cagatcccag acccccatct ggccgatcca accgtgctgg aagcactgag     1980

gcagaaggcc aacttcaaac actacaagcc caaacagttc agcatgctgg agtttctgca     2040

ccgcgtggga catgacctga aagatatgat gctgtattgc aagttcaaag gccaggagtg     2100

tgggcatcag gacttcacta ccgtgtttac aaagtacggc aaatgttaca tgttcaactc     2160

cggggaagat ggaaaacctc tgctgacaac tgtgaagggc gggacaggga atggactgga     2220

gatcatgctg gacattcagc aggatgagta cctgccaatc tggggagaaa ctgaggaaac     2280

cacattcgag gccggcgtga aggtccagat ccactcacag agcgagcccc ctttcattca     2340

ggaactggga tttggagtgg caccaggatt ccagacattt gtcgctactc aggagcagcg     2400

cctgacctat ctgccacccc cttggggcga gtgccgatct agtgaaatgg ggctggactt     2460

ctttcctgtg tactctatca ccgcctgccg aattgattgt gagacacggt atatcgtgga     2520

aaactgcaat tgtaggatgg tccacatgcc tggcgacgcc ccattctgca ctcccgaaca     2580

gcataaagag tgtgctgaac ctgcactggg gctgctggct gagaaggata gtaactactg     2640

cctgtgtaga acaccctgta acctgactag gtataataag gaactgagca tggtgaagat     2700

cccttccaaa acatctgcaa agtacctgga gaagaagttc aacaagtctg agaagtacat     2760

cagtgaaaac attctggtgc tggacatctt ctttgaagct ctgaattacg agaccattga     2820

acagaagaaa gcatatgagg tggccgctct gctgggggat attggaggcc agatgggact     2880

gttcatcggc gccagcctgc tgacaattct ggagctgttt gactacatct atgagctgat     2940

taaggaaaaa ctgctggatc tgctggggaa ggaggaagag gaaggatcac acgacgaaaa     3000

catgagcact tgcgatacca tgcctaatca cagcgagacc atctcccata cagtgaatgt     3060

cccactgcag actgcactgg gcaccctgga ggaaattgcc tgtgcggccg ccaagagcag     3120

gatcaccagc gagggcgagt acatccccct ggaccagatc gacatcaacg tggtgagcaa     3180

gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa     3240

cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac     3300

cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac     3360

cttcggctac ggcctgcagt gcttcgcccg ctaccccgac cacatgaagc agcacgactt     3420

cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga     3480

cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat     3540

cgagctgaag ggcatcgact tcagggagga cggcaacatc ctggggcaca agctggagta     3600

caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt     3660

gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca     3720

gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcta     3780

ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt     3840

cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagttct gctacgagaa     3900

cgaggtgtaa tgagaattcg atatcaagct tatcgataat caacctctgg attacaaaat     3960

ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc     4020

tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt     4080

gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg     4140

cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg     4200

tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc     4260

cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt     4320

gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca cctggattct     4380

gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg     4440

cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg     4500

gatctccctt tgggccgcct ccccgcatcg ataccgagcg ctgctcgaga gatctacggg     4560

tggcatccct gtgacccctc cccagtgcct ctcctggccc tggaagttgc cactccagtg     4620

cccaccagcc ttgtcctaat aaaattaagt tgcatcattt tgtctgacta ggtgtccttc     4680

tataatatta tggggtggag gggggtggta tggagcaagg ggcaagttgg gaagacaacc     4740

tgtagggcct gcggggtcta ttgggaacca agctggagtg cagtggcaca atcttggctc     4800

actgcaatct ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc cgagttgttg     4860

ggattccagg catgcatgac caggctcagc taatttttgt ttttttggta gagacggggt     4920

ttcaccatat tggccaggct ggtctccaac tcctaatctc aggtgatcta cccaccttgg     4980

cctcccaaat tgctgggatt acaggcgtga accactgctc ccttccctgt ccttctgatt     5040

ttgtaggtaa ccacgtgcgg accgagcggc cgcaggaacc cctagtgatg gagttggcca     5100

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     5160

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc     5220

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata cgtcaaagca     5280

accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     5340

cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt     5400

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     5460

ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg atggttcacg     5520

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     5580

taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg gctattcttt     5640

tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca     5700

aaaatttaac gcgaatttta acaaaatatt aacgtttaca attttatggt gcactctcag     5760

tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga     5820

cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc     5880

cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg     5940

cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc     6000

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca     6060

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa     6120

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt     6180

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca     6240

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag     6300

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc     6360

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca     6420

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt     6480

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct     6540

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt     6600

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga     6660

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact     6720

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc     6780

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga     6840

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt     6900

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga     6960

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     7020

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     7080

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     7140

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     7200

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     7260

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     7320

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     7380

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     7440

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     7500

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     7560

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     7620

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     7680

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     7740

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     7800

tgctcacatg t                                                          7811


<210>  51
<211>  348
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Val Tyr Gly Ser Thr Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val 
            340                 345             


<210>  52
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Ala Glu Leu Ile Ser Ser Ala Thr Arg Ser Leu Phe Ala Ala Gly 
1               5                   10                  15      


Gly Ile Asn Pro Trp Pro Asn Pro Tyr His His Glu Asp Met Gly Cys 
            20                  25                  30          


Gly Gly Met Thr Pro Thr Gly Glu Cys Phe Ser Thr Glu Trp Trp Cys 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Ser Asp Ala Gly Tyr Gly Tyr Cys Phe Val 
    50                  55                  60                  


Glu Ala Thr Gly Gly Tyr Leu Val Val Gly Val Glu Lys Lys Gln Ala 
65                  70                  75                  80  


Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val 
                85                  90                  95      


Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr 
            100                 105                 110         


Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val 
        115                 120                 125             


Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe 
    130                 135                 140                 


Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys 
145                 150                 155                 160 


Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Arg 
                165                 170                 175     


Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met 
            180                 185                 190         


Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly Met Ala Ala 
        195                 200                 205             


Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys 
    210                 215                 220                 


Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu 
225                 230                 235                 240 


Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val Val Lys Leu 
                245                 250                 255     


Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp 
            260                 265                 270         


Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser 
        275                 280                 285             


Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe 
    290                 295                 300                 


Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile Leu Ile His 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val 
                325                 330                 335     


Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr Val 
            340                 345                 350 


<210>  53
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Thr Pro Val Ile Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Lys Tyr Gly Ser Asn Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Gln Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Ser Ser Glu Asp 
            340                 345                 350         


Leu Tyr Phe Gln 
        355     


<210>  54
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Ala Thr Ile Ser Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Ala 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ala Asn Asp 
    130                 135                 140                 


Tyr Asn Lys Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Thr Thr Ala Ala Leu Ser Lys Gly Tyr Val Arg Val Ile 
                165                 170                 175     


Phe Phe Leu Met Gly Leu Cys Tyr Gly Ile Tyr Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  55
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Asn Ile Tyr Val Ala Thr Ile Gln Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Arg Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Ala 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ala Asn Asp 
    130                 135                 140                 


Tyr Asn Lys Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Thr Thr Ala Ala Leu Ser Lys Gly Tyr Val Arg Val Ile 
                165                 170                 175     


Phe Phe Leu Met Gly Leu Cys Tyr Gly Ile Tyr Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Arg Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Ser His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  56
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Ala Thr Ile Ser Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ala Asn Asp 
    130                 135                 140                 


Tyr Asn Lys Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Thr Thr Ala Ala Leu Ser Lys Gly Tyr Val Arg Val Ile 
                165                 170                 175     


Phe Phe Leu Met Gly Leu Cys Tyr Gly Ile Tyr Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  57
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Asn Ile Tyr Val Ala Thr Ile Gln Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Arg Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ala Asn Asp 
    130                 135                 140                 


Tyr Asn Lys Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Thr Thr Ala Ala Leu Ser Lys Gly Tyr Val Arg Val Ile 
                165                 170                 175     


Phe Phe Leu Met Gly Leu Cys Tyr Gly Ile Tyr Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Arg Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Ser His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  58
<211>  296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp Arg Pro Val Val Ala Val Ser Lys Ala Ala Ala Lys Ser Arg 
            260                 265                 270         


Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn 
        275                 280                 285             


Val Phe Cys Tyr Glu Asn Glu Val 
    290                 295     


<210>  59
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Ile Val Lys Gly Trp Gly Val Thr Asp Lys Glu 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ser Ile Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Ala Gly Glu Val Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Ser Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Pro Leu Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ala Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro 
                245             


<210>  60
<211>  1293
<212>  DNA
<213>  Mus musculus

<400>  60
ttaacattat ggccttaggt cacttcatct ccatggggtt cttcttctga ttttctagaa       60

aatgagatgg gggtgcagag agcttcctca gtgacctgcc cagggtcaca tcagaaatgt      120

cagagctaga acttgaactc agattactaa tcttaaattc catgccttgg gggcatgcaa      180

gtacgatata cagaaggagt gaactcatta gggcagatga ccaatgagtt taggaaagaa      240

gagtccaggg cagggtacat ctacaccacc cgcccagccc tgggtgagtc cagccacgtt      300

cacctcatta tagttgcctc tctccagtcc taccttgacg ggaagcacaa gcagaaactg      360

ggacaggagc cccaggagac caaatcttca tggtccctct gggaggatgg gtggggagag      420

ctgtggcaga ggcctcagga ggggccctgc tgctcagtgg tgacagatag gggtgagaaa      480

gcagacagag tcattccgtc agcattctgg gtctgtttgg tacttcttct cacgctaagg      540

tggcggtgtg atatgcacaa tggctaaaaa gcagggagag ctggaaagaa acaaggacag      600

agacagaggc caagtcaacc agaccaattc ccagaggaag caaagaaacc attacagaga      660

ctacaagggg gaagggaagg agagatgaat tagcttcccc tgtaaacctt agaacccagc      720

tgttgccagg gcaacggggc aatacctgtc tcttcagagg agatgaagtt gccagggtaa      780

ctacatcctg tctttctcaa ggaccatccc agaatgtggc acccactagc cgttaccata      840

gcaactgcct ctttgcccca cttaatccca tcccgtctgt taaaagggcc ctatagttgg      900

aggtggggga ggtaggaaga gcgatgatca cttgtggact aagtttgttc gcatcccctt      960

ctccaacccc ctcagtacat caccctgggg gaacagggtc cacttgctcc tgggcccaca     1020

cagtcctgca gtattgtgta tataaggcca gggcaaagag gagcaggttt taaagtgaaa     1080

ggcaggcagg tgttggggag gcagttaccg gggcaacggg aacagggcgt ttcggaggtg     1140

gttgccatgg ggacctggat gctgacgaag gctcgcgagg ctgtgagcag ccacagtgcc     1200

ctgctcagaa gccccaagct cgtcagtcaa gccggttctc cgtttgcact caggagcacg     1260

ggcaggcgag tggcccctag ttctgggggc agc                                  1293


<210>  61
<211>  359
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr 
            100                 105                 110         


Gln Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr 
        115                 120                 125             


Ile Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu 
    130                 135                 140                 


Pro Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg 
145                 150                 155                 160 


Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu 
        195                 200                 205             


Ser Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr 
    210                 215                 220                 


Gly Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly Val Leu Ser Val Tyr Gly Ser Thr Val Gly 
        275                 280                 285             


His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp Gly Leu Leu Gly 
    290                 295                 300                 


His Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val 
                325                 330                 335     


Glu Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Asn Lys Gly 
            340                 345                 350         


Thr Gly Lys Tyr Glu Ser Ser 
        355                 


<210>  62
<211>  325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Glu Thr Ala Ala Thr Met Thr His Ala Phe Ile Ser Ala Val Pro 
1               5                   10                  15      


Ser Ala Glu Ala Thr Ile Arg Gly Leu Leu Ser Ala Ala Ala Val Val 
            20                  25                  30          


Thr Pro Ala Ala Asp Ala His Gly Glu Thr Ser Asn Ala Thr Thr Ala 
        35                  40                  45              


Gly Ala Asp His Gly Cys Phe Pro His Ile Asn His Gly Thr Glu Leu 
    50                  55                  60                  


Gln His Lys Ile Ala Val Gly Leu Gln Trp Phe Thr Val Ile Val Ala 
65                  70                  75                  80  


Ile Val Gln Leu Ile Phe Tyr Gly Trp His Ser Phe Lys Ala Thr Thr 
                85                  90                  95      


Gly Trp Glu Glu Val Tyr Val Cys Val Ile Glu Leu Val Lys Cys Phe 
            100                 105                 110         


Ile Glu Leu Phe His Glu Val Asp Ser Pro Ala Thr Val Tyr Gln Thr 
        115                 120                 125             


Asn Gly Gly Ala Val Ile Trp Leu Arg Tyr Ser Met Trp Leu Leu Thr 
    130                 135                 140                 


Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu His Glu 
145                 150                 155                 160 


Glu Tyr Ser Lys Arg Thr Met Thr Ile Leu Val Thr Asp Ile Gly Asn 
                165                 170                 175     


Ile Val Trp Gly Ile Thr Ala Ala Phe Thr Lys Gly Pro Leu Lys Ile 
            180                 185                 190         


Leu Phe Phe Met Ile Gly Leu Phe Tyr Gly Val Thr Cys Phe Phe Gln 
        195                 200                 205             


Ile Ala Lys Val Tyr Ile Glu Ser Tyr His Thr Leu Pro Lys Gly Val 
    210                 215                 220                 


Cys Arg Lys Ile Cys Lys Ile Met Ala Tyr Val Phe Phe Cys Ser Trp 
225                 230                 235                 240 


Leu Met Phe Pro Val Met Phe Ile Ala Gly His Glu Gly Leu Gly Leu 
                245                 250                 255     


Ile Thr Pro Tyr Thr Ser Gly Ile Gly His Leu Ile Leu Asp Leu Ile 
            260                 265                 270         


Ser Lys Asn Thr Trp Gly Phe Leu Gly His His Leu Arg Val Lys Ile 
        275                 280                 285             


His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Thr Ile 
    290                 295                 300                 


Asn Val Ala Gly Glu Asn Met Glu Ile Glu Thr Phe Val Asp Glu Glu 
305                 310                 315                 320 


Glu Glu Gly Gly Val 
                325 


<210>  63
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Thr Ala Val Ser Thr Thr Ala Thr Thr Val Leu Gln Ala Thr Gln 
1               5                   10                  15      


Ser Asp Val Leu Gln Glu Ile Gln Ser Asn Phe Leu Leu Asn Ser Ser 
            20                  25                  30          


Ile Trp Val Asn Ile Ala Leu Ala Gly Val Val Ile Leu Leu Phe Val 
        35                  40                  45              


Ala Met Gly Arg Asp Leu Glu Ser Pro Arg Ala Lys Leu Ile Trp Val 
    50                  55                  60                  


Ala Thr Met Leu Val Pro Leu Val Ser Ile Ser Ser Tyr Ala Gly Leu 
65                  70                  75                  80  


Ala Ser Gly Leu Thr Val Gly Phe Leu Gln Met Pro Pro Gly His Ala 
                85                  90                  95      


Leu Ala Gly Gln Glu Val Leu Ser Pro Trp Gly Arg Tyr Leu Thr Trp 
            100                 105                 110         


Thr Phe Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Asp 
        115                 120                 125             


Thr Asp Ile Ala Ser Leu Phe Thr Ala Ile Thr Met Asp Ile Gly Met 
    130                 135                 140                 


Cys Val Thr Gly Leu Ala Ala Ala Leu Ile Thr Ser Ser His Leu Leu 
145                 150                 155                 160 


Arg Trp Val Phe Tyr Gly Ile Ser Cys Ala Phe Phe Val Ala Val Leu 
                165                 170                 175     


Tyr Val Leu Leu Val Gln Trp Pro Ala Asp Ala Glu Ala Ala Gly Thr 
            180                 185                 190         


Ser Glu Ile Phe Gly Thr Leu Arg Ile Leu Thr Val Val Leu Trp Leu 
        195                 200                 205             


Gly Tyr Pro Ile Leu Phe Ala Leu Gly Ser Glu Gly Val Ala Leu Leu 
    210                 215                 220                 


Ser Val Gly Val Thr Ser Trp Gly Tyr Ser Gly Leu Asp Ile Leu Ala 
225                 230                 235                 240 


Lys Tyr Val Phe Ala Phe Leu Leu Leu Arg Trp Val Ala Ala Asn Glu 
                245                 250                 255     


Gly Thr Val Ser Gly Ser Gly Met Gly Ile Gly Ser Gly Gly Ala Ala 
            260                 265                 270         


Pro Ala Asp Asp 
        275     


