
                                SEQUENCE LISTING

<110> DOPHEN BIOMEDICAL
      HU, Sean
      ALLEN, Lisha

<120> HOMOGENOUS ANTIBODY DRUG CONJUGATES VIA
  ENZYMATIC METHODS

<130> 720692000140

<140> PCT/US2015/035375   
<141> 2015-06-11  

<150> US 62/011,534       
<151> 2014-06-12  

<160> 43

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 7, 11
<223> Xaa = Y or F

<400> 1
Lys Pro Arg Glu Glu Gln Xaa Asn Ser Thr Xaa Arg
 1               5                  10          


<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
 1               5                  10          


<210> 3
<211> 110
<212> PRT
<213> Homo sapiens

<400> 3
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 4
<211> 109
<212> PRT
<213> Homo sapiens

<400> 4
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
 1               5                  10                  15      
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
            20                  25                  30          
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
        35                  40                  45              
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
    50                  55                  60                  
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln
65                  70                  75                  80  
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
                85                  90                  95      
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
            100                 105                 


<210> 5
<211> 110
<212> PRT
<213> Homo sapiens

<400> 5
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
            100                 105                 110 


<210> 6
<211> 110
<212> PRT
<213> Homo sapiens

<400> 6
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 7
<211> 107
<212> PRT
<213> Mus musculus

<400> 7
Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp
 1               5                  10                  15      
Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp
            20                  25                  30          
Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp
        35                  40                  45              
Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn
    50                  55                  60                  
Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp
65                  70                  75                  80  
Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro
                85                  90                  95      
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
            100                 105         


<210> 8
<211> 110
<212> PRT
<213> Mus musculus

<400> 8
Ala Pro Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
 1               5                  10                  15      
Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
        35                  40                  45              
Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
    50                  55                  60                  
Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
65                  70                  75                  80  
Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg
                85                  90                  95      
Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg
            100                 105                 110 


<210> 9
<211> 110
<212> PRT
<213> Mus musculus

<400> 9
Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
 1               5                  10                  15      
Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
        35                  40                  45              
Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
    50                  55                  60                  
Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His
65                  70                  75                  80  
Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
                85                  90                  95      
Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys
            100                 105                 110 


<210> 10
<211> 110
<212> PRT
<213> Mus musculus

<400> 10
Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn
 1               5                  10                  15      
Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe
        35                  40                  45              
Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu
    50                  55                  60                  
Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His
65                  70                  75                  80  
Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
                85                  90                  95      
Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys
            100                 105                 110 


<210> 11
<211> 110
<212> PRT
<213> Mus musculus

<400> 11
Ala Gly Asn Ile Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Ala Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val His Val Ser Trp Phe
        35                  40                  45              
Val Asp Asn Lys Glu Val His Thr Ala Trp Thr Gln Pro Arg Glu Ala
    50                  55                  60                  
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln His
65                  70                  75                  80  
Gln Asp Trp Met Arg Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys
            100                 105                 110 


<210> 12
<211> 107
<212> PRT
<213> Rattus norvegicus

<400> 12
Gly Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp
 1               5                  10                  15      
Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp
            20                  25                  30          
Ile Ser Gln Asn Asp Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp
        35                  40                  45              
Val Glu Val His Thr Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn
    50                  55                  60                  
Ser Thr Leu Arg Ser Val Ser Glu Leu Pro Ile Val His Arg Asp Trp
65                  70                  75                  80  
Leu Asn Gly Lys Thr Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro
                85                  90                  95      
Ala Pro Ile Glu Lys Ser Ile Ser Lys Pro Glu
            100                 105         


<210> 13
<211> 107
<212> PRT
<213> Rattus norvegicus

<400> 13
Gly Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp
 1               5                  10                  15      
Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp
            20                  25                  30          
Ile Ser Gln Asp Asp Pro Glu Val His Phe Ser Trp Phe Val Asp Asp
        35                  40                  45              
Val Glu Val His Thr Ala Gln Thr Arg Pro Pro Glu Glu Gln Phe Asn
    50                  55                  60                  
Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Leu His Gln Asp Trp
65                  70                  75                  80  
Leu Asn Gly Arg Thr Phe Arg Cys Lys Val Thr Ser Ala Ala Phe Pro
                85                  90                  95      
Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Glu
            100                 105         


<210> 14
<211> 110
<212> PRT
<213> Rattus norvegicus

<400> 14
Val Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Ile Leu Leu Ile Ser Gln Asn Ala Lys Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Glu Glu Glu Pro Asp Val Gln Phe Ser Trp Phe
        35                  40                  45              
Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln His
65                  70                  75                  80  
Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
                85                  90                  95      
Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Lys
            100                 105                 110 


<210> 15
<211> 109
<212> PRT
<213> Rattus norvegicus

<400> 15
Asp Asp Asn Leu Gly Arg Pro Ser Val Phe Ile Phe Pro Pro Lys Pro
 1               5                  10                  15      
Lys Asp Ile Leu Met Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val
            20                  25                  30          
Val Asp Val Ser Glu Glu Glu Pro Asp Val Gln Phe Ser Trp Phe Val
        35                  40                  45              
Asp Asn Val Arg Val Phe Thr Ala Gln Thr Gln Pro His Glu Glu Gln
    50                  55                  60                  
Leu Asn Gly Thr Phe Arg Val Val Ser Thr Leu His Ile Gln His Gln
65                  70                  75                  80  
Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp
                85                  90                  95      
Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg
            100                 105                 


<210> 16
<211> 331
<212> PRT
<213> Strep Ladakanum

<400> 16
Asp Ser Asp Glu Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met
 1               5                  10                  15      
Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn
            20                  25                  30          
Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg
        35                  40                  45              
Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys
    50                  55                  60                  
Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu
65                  70                  75                  80  
Ala Phe Ala Phe Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn
                85                  90                  95      
Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val
            100                 105                 110         
Ala Lys Asp Ser Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp
        115                 120                 125             
Val Ala Ser Val Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly
    130                 135                 140                 
Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala
145                 150                 155                 160 
Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn
                165                 170                 175     
Thr Pro Ser Phe Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys
            180                 185                 190         
Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg
        195                 200                 205             
Ser Gly Ser Ser Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg
    210                 215                 220                 
Pro Asp Arg Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile
225                 230                 235                 240 
Pro Arg Ser Pro Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp Tyr
                245                 250                 255     
Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp
            260                 265                 270         
Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met
        275                 280                 285             
His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr Ser Asp
    290                 295                 300                 
Phe Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro Lys Ser Trp Asn
305                 310                 315                 320 
Thr Ala Pro Asp Lys Val Thr Gln Gly Trp Pro
                325                 330     


<210> 17
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Pro Asp Ser Asp Glu Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg
 1               5                  10                  15      
Met Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val
            20                  25                  30          
Asn Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly
        35                  40                  45              
Arg Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly
    50                  55                  60                  
Cys Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg
65                  70                  75                  80  
Leu Ala Phe Ala Phe Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys
                85                  90                  95      
Asn Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg
            100                 105                 110         
Val Ala Lys Asp Ser Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg
        115                 120                 125             
Asp Val Ala Ser Val Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu
    130                 135                 140                 
Gly Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp
145                 150                 155                 160 
Ala Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg
                165                 170                 175     
Asn Thr Pro Ser Phe Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser
            180                 185                 190         
Lys Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp
        195                 200                 205             
Arg Ser Gly Ser Ser Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe
    210                 215                 220                 
Arg Pro Asp Arg Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn
225                 230                 235                 240 
Ile Pro Arg Ser Pro Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp
                245                 250                 255     
Tyr Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val
            260                 265                 270         
Trp Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala
        275                 280                 285             
Met His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr Ser
    290                 295                 300                 
Asp Phe Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro Lys Ser Trp
305                 310                 315                 320 
Asn Thr Ala Pro Asp Lys Val Thr Gln Gly Trp Pro Leu Glu His His
                325                 330                 335     
His His His His His His
            340         


<210> 18
<211> 331
<212> PRT
<213> Strep Mobaraensis

<400> 18
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met
 1               5                  10                  15      
Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn
            20                  25                  30          
Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg
        35                  40                  45              
Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys
    50                  55                  60                  
Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu
65                  70                  75                  80  
Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn
                85                  90                  95      
Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val
            100                 105                 110         
Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu
        115                 120                 125             
Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser
    130                 135                 140                 
Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala
145                 150                 155                 160 
Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn
                165                 170                 175     
Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg
            180                 185                 190         
Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg
        195                 200                 205             
Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg
    210                 215                 220                 
Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile
225                 230                 235                 240 
Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr
                245                 250                 255     
Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp
            260                 265                 270         
Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met
        275                 280                 285             
His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Glu Gly Tyr Ser Asp
    290                 295                 300                 
Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn
305                 310                 315                 320 
Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro
                325                 330     


<210> 19
<211> 331
<212> PRT
<213> Artificial Sequence

<220> 
<223> Consensus Sequence

<220> 
<221> VARIANT        
<222> 4, 30, 84, 89, 90, 115, 120, 128, 135, 144, 182, 192, 210,
212, 221, 226, 227, 250, 300, 312, 315, 327
<223> Xaa = Any Amino Acid

<400> 19
Asp Ser Asp Xaa Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met
 1               5                  10                  15      
Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Xaa Val Asn
            20                  25                  30          
Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg
        35                  40                  45              
Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys
    50                  55                  60                  
Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu
65                  70                  75                  80  
Ala Phe Ala Xaa Phe Asp Glu Asp Xaa Xaa Lys Asn Glu Leu Lys Asn
                85                  90                  95      
Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val
            100                 105                 110         
Ala Lys Xaa Ser Phe Asp Glu Xaa Lys Gly Phe Gln Arg Ala Arg Xaa
        115                 120                 125             
Val Ala Ser Val Met Asn Xaa Ala Leu Glu Asn Ala His Asp Glu Xaa
    130                 135                 140                 
Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala
145                 150                 155                 160 
Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn
                165                 170                 175     
Thr Pro Ser Phe Lys Xaa Arg Asn Gly Gly Asn His Asp Pro Ser Xaa
            180                 185                 190         
Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg
        195                 200                 205             
Ser Xaa Ser Xaa Asp Lys Arg Lys Tyr Gly Asp Pro Xaa Ala Phe Arg
    210                 215                 220                 
Pro Xaa Xaa Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile
225                 230                 235                 240 
Pro Arg Ser Pro Thr Ser Pro Gly Glu Xaa Phe Val Asn Phe Asp Tyr
                245                 250                 255     
Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp
            260                 265                 270         
Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met
        275                 280                 285             
His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Xaa Gly Tyr Ser Asp
    290                 295                 300                 
Phe Asp Arg Gly Ala Tyr Val Xaa Thr Phe Xaa Pro Lys Ser Trp Asn
305                 310                 315                 320 
Thr Ala Pro Asp Lys Val Xaa Gln Gly Trp Pro
                325                 330     


<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg
            


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Val Glu Ser Gly Gly Gly Leu Gln Pro Gly Gly Ser Leu
 1               5                  10              


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg
 1               5                  10          


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
 1               5                  10      


<210> 24
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
 1               5                  10                  15      
Leu Val Thr Val Ser Ser Ala Ser Thr Lys
            20                  25      


<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
 1               5                  10                  15      


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Gly Thr Gln Thr Tyr
 1               5  


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Glu Glu Gln Tyr Asp Ser Thr Tyr Arg
 1               5                  


<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
 1               5                  10      


<210> 29
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg
            


<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
 1               5                  10                  15  


<210> 31
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
 1               5                  10      


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
 1               5                  10      


<210> 33
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
 1               5                  10                  15      
Pro Glu Asn Asn Tyr Lys
            20          


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
 1               5                  10              


<210> 35
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
 1               5                  10                  15      
His Asn His Tyr Thr Gln Lys
            20              


<210> 36
<211> 343
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Met Pro Asp Ser Asp Glu Arg Val Thr Pro Pro Ala Glu Pro Leu Asp
 1               5                  10                  15      
Arg Met Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile
            20                  25                  30          
Val Asn Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp
        35                  40                  45              
Gly Arg Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr
    50                  55                  60                  
Gly Cys Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn
65                  70                  75                  80  
Arg Leu Ala Phe Ala Phe Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu
                85                  90                  95      
Lys Asn Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly
            100                 105                 110         
Arg Val Ala Lys Asp Ser Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala
        115                 120                 125             
Arg Asp Val Ala Ser Val Met Asn Lys Ala Leu Glu Asn Ala His Asp
    130                 135                 140                 
Glu Gly Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn
145                 150                 155                 160 
Asp Ala Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu
                165                 170                 175     
Arg Asn Thr Pro Ser Phe Lys Asp Arg Asn Gly Gly Asn His Asp Pro
            180                 185                 190         
Ser Lys Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln
        195                 200                 205             
Asp Arg Ser Gly Ser Ser Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala
    210                 215                 220                 
Phe Arg Pro Asp Arg Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg
225                 230                 235                 240 
Asn Ile Pro Arg Ser Pro Thr Ser Pro Gly Glu Ser Phe Val Asn Phe
                245                 250                 255     
Asp Tyr Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr
            260                 265                 270         
Val Trp Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly
        275                 280                 285             
Ala Met His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr
    290                 295                 300                 
Ser Asp Phe Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro Lys Ser
305                 310                 315                 320 
Trp Asn Thr Ala Pro Asp Lys Val Thr Gln Gly Trp Pro Leu Glu His
                325                 330                 335     
His His His His His His His
            340             


<210> 37
<211> 337
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr
 1               5                  10                  15      
Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn Asn Tyr Ile Arg
            20                  25                  30          
Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met
        35                  40                  45              
Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr
    50                  55                  60                  
Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Phe
65                  70                  75                  80  
Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg
                85                  90                  95      
Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Asp Ser
            100                 105                 110         
Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp Val Ala Ser Val
        115                 120                 125             
Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly Ala Tyr Leu Asp
    130                 135                 140                 
Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu
145                 150                 155                 160 
Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe
                165                 170                 175     
Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys Met Lys Ala Val
            180                 185                 190         
Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Gly Ser Ser
        195                 200                 205             
Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg Pro Asp Arg Gly
    210                 215                 220                 
Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Pro
225                 230                 235                 240 
Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly
                245                 250                 255     
Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn
            260                 265                 270         
His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met His Val Tyr Glu
        275                 280                 285             
Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr Ser Asp Phe Asp Arg Gly
    290                 295                 300                 
Ala Tyr Val Val Thr Phe Val Pro Lys Ser Trp Asn Thr Ala Pro Asp
305                 310                 315                 320 
Lys Val Thr Gln Gly Trp Pro Leu Glu His His His His His His His
                325                 330                 335     
His
    


<210> 38
<211> 338
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Pro Asp Ser Asp Glu Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg
 1               5                  10                  15      
Met Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val
            20                  25                  30          
Asn Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly
        35                  40                  45              
Arg Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly
    50                  55                  60                  
Cys Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg
65                  70                  75                  80  
Leu Ala Phe Ala Phe Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys
                85                  90                  95      
Asn Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg
            100                 105                 110         
Val Ala Lys Asp Ser Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg
        115                 120                 125             
Asp Val Ala Ser Val Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu
    130                 135                 140                 
Gly Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp
145                 150                 155                 160 
Ala Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg
                165                 170                 175     
Asn Thr Pro Ser Phe Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser
            180                 185                 190         
Lys Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp
        195                 200                 205             
Arg Ser Gly Ser Ser Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe
    210                 215                 220                 
Arg Pro Asp Arg Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn
225                 230                 235                 240 
Ile Pro Arg Ser Gly Glu Ser Phe Val Asn Phe Asp Tyr Gly Trp Phe
                245                 250                 255     
Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly
            260                 265                 270         
Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met His Val Tyr
        275                 280                 285             
Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr Ser Asp Phe Asp Arg
    290                 295                 300                 
Gly Ala Tyr Val Val Thr Phe Val Pro Lys Ser Trp Asn Thr Ala Pro
305                 310                 315                 320 
Asp Lys Val Thr Gln Gly Trp Pro Leu Glu His His His His His His
                325                 330                 335     
His His
        


<210> 39
<211> 338
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Pro Asp Ser Asp Glu Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg
 1               5                  10                  15      
Met Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val
            20                  25                  30          
Asn Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly
        35                  40                  45              
Arg Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly
    50                  55                  60                  
Cys Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg
65                  70                  75                  80  
Leu Ala Phe Ala Phe Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys
                85                  90                  95      
Asn Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg
            100                 105                 110         
Val Ala Lys Asp Ser Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg
        115                 120                 125             
Asp Val Ala Ser Val Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu
    130                 135                 140                 
Gly Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp
145                 150                 155                 160 
Ala Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg
                165                 170                 175     
Asn Thr Pro Ser Phe Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser
            180                 185                 190         
Lys Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp
        195                 200                 205             
Arg Ser Gly Ser Ser Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe
    210                 215                 220                 
Arg Pro Asp Arg Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn
225                 230                 235                 240 
Ile Pro Arg Ser Pro Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp
                245                 250                 255     
Tyr Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val
            260                 265                 270         
Trp Thr His Gly Asn His Tyr His Ala Pro Gly Ala Met His Val Tyr
        275                 280                 285             
Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly Tyr Ser Asp Phe Asp Arg
    290                 295                 300                 
Gly Ala Tyr Val Val Thr Phe Val Pro Lys Ser Trp Asn Thr Ala Pro
305                 310                 315                 320 
Asp Lys Val Thr Gln Gly Trp Pro Leu Glu His His His His His His
                325                 330                 335     
His His
        


<210> 40
<211> 333
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr
 1               5                  10                  15      
Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn Asn Tyr Ile Arg
            20                  25                  30          
Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met
        35                  40                  45              
Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr
    50                  55                  60                  
Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Phe
65                  70                  75                  80  
Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg
                85                  90                  95      
Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Asp Ser
            100                 105                 110         
Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp Val Ala Ser Val
        115                 120                 125             
Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly Ala Tyr Leu Asp
    130                 135                 140                 
Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu
145                 150                 155                 160 
Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe
                165                 170                 175     
Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys Met Lys Ala Val
            180                 185                 190         
Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Gly Ser Ser
        195                 200                 205             
Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg Pro Asp Arg Gly
    210                 215                 220                 
Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Pro
225                 230                 235                 240 
Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly
                245                 250                 255     
Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn
            260                 265                 270         
His Tyr His Ala Pro Gly Ala Met His Val Tyr Glu Ser Lys Phe Arg
        275                 280                 285             
Asn Trp Ser Asp Gly Tyr Ser Asp Phe Asp Arg Gly Ala Tyr Val Val
    290                 295                 300                 
Thr Phe Val Pro Lys Ser Trp Asn Thr Ala Pro Asp Lys Val Thr Gln
305                 310                 315                 320 
Gly Trp Pro Leu Glu His His His His His His His His
                325                 330             


<210> 41
<211> 329
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr
 1               5                  10                  15      
Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn Asn Tyr Ile Arg
            20                  25                  30          
Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met
        35                  40                  45              
Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr
    50                  55                  60                  
Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Phe
65                  70                  75                  80  
Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg
                85                  90                  95      
Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Asp Ser
            100                 105                 110         
Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp Val Ala Ser Val
        115                 120                 125             
Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly Ala Tyr Leu Asp
    130                 135                 140                 
Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu
145                 150                 155                 160 
Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe
                165                 170                 175     
Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys Met Lys Ala Val
            180                 185                 190         
Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Gly Ser Ser
        195                 200                 205             
Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg Pro Asp Arg Gly
    210                 215                 220                 
Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Gly
225                 230                 235                 240 
Glu Ser Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly Ala Gln Thr Glu
                245                 250                 255     
Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn His Tyr His Ala
            260                 265                 270         
Pro Gly Ala Met His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp
        275                 280                 285             
Gly Tyr Ser Asp Phe Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro
    290                 295                 300                 
Lys Ser Trp Asn Thr Ala Pro Asp Lys Val Thr Gln Gly Trp Pro Leu
305                 310                 315                 320 
Glu His His His His His His His His
                325                 


<210> 42
<211> 329
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr
 1               5                  10                  15      
Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn Asn Tyr Ile Arg
            20                  25                  30          
Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met
        35                  40                  45              
Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr
    50                  55                  60                  
Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Phe
65                  70                  75                  80  
Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg
                85                  90                  95      
Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Asp Ser
            100                 105                 110         
Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp Val Ala Ser Val
        115                 120                 125             
Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly Ala Tyr Leu Asp
    130                 135                 140                 
Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu
145                 150                 155                 160 
Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe
                165                 170                 175     
Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys Met Lys Ala Val
            180                 185                 190         
Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Gly Ser Ser
        195                 200                 205             
Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg Pro Asp Arg Gly
    210                 215                 220                 
Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Pro
225                 230                 235                 240 
Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly
                245                 250                 255     
Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn
            260                 265                 270         
His Tyr Gly Met His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp
        275                 280                 285             
Gly Tyr Ser Asp Phe Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro
    290                 295                 300                 
Lys Ser Trp Asn Thr Ala Pro Asp Lys Val Thr Gln Gly Trp Pro Leu
305                 310                 315                 320 
Glu His His His His His His His His
                325                 


<210> 43
<211> 328
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met Pro Asp Pro Tyr
 1               5                  10                  15      
Arg Pro Ser Tyr Gly Arg Ala Glu Thr Ile Val Asn Asn Tyr Ile Arg
            20                  25                  30          
Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg Lys Gln Gln Met
        35                  40                  45              
Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys Val Gly Val Thr
    50                  55                  60                  
Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu Ala Phe Ala Phe
65                  70                  75                  80  
Phe Asp Glu Asp Lys Tyr Lys Asn Glu Leu Lys Asn Gly Arg Pro Arg
                85                  90                  95      
Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val Ala Lys Asp Ser
            100                 105                 110         
Phe Asp Glu Ala Lys Gly Phe Gln Arg Ala Arg Asp Val Ala Ser Val
        115                 120                 125             
Met Asn Lys Ala Leu Glu Asn Ala His Asp Glu Gly Ala Tyr Leu Asp
    130                 135                 140                 
Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala Leu Arg Asn Glu
145                 150                 155                 160 
Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn Thr Pro Ser Phe
                165                 170                 175     
Lys Asp Arg Asn Gly Gly Asn His Asp Pro Ser Lys Met Lys Ala Val
            180                 185                 190         
Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg Ser Gly Ser Ser
        195                 200                 205             
Asp Lys Arg Lys Tyr Gly Asp Pro Glu Ala Phe Arg Pro Asp Arg Gly
    210                 215                 220                 
Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile Pro Arg Ser Pro
225                 230                 235                 240 
Thr Ser Pro Gly Glu Ser Phe Val Asn Phe Asp Tyr Gly Trp Phe Gly
                245                 250                 255     
Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp Thr His Gly Asn
            260                 265                 270         
His Tyr His Gly Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Asp Gly
        275                 280                 285             
Tyr Ser Asp Phe Asp Arg Gly Ala Tyr Val Val Thr Phe Val Pro Lys
    290                 295                 300                 
Ser Trp Asn Thr Ala Pro Asp Lys Val Thr Gln Gly Trp Pro Leu Glu
305                 310                 315                 320 
His His His His His His His His
                325             

