                         SEQUENCE LISTING

<110>  Vasculox, Inc.
       Frazier, William
       Manning, Pamela
       Frey, Gerhard
       Chang, Hwai Wen
 
<120>  Therapeutic CD47 Antibodies

<130>  VLX0001-402-PC

<150>  14/302,348
<151>  2014-06-11

<160>  124    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain complementarity determining region

<400>  1

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain complementarity determining region

<400>  2

Lys Val Ser Tyr Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain complementarity determining region

<400>  3

Ser Gln Asn Thr His Val Pro Arg Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain complementarity determining region

<400>  4

Gly Tyr Thr Phe Thr Asn Tyr Tyr Val Phe 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain complementarity determining region

<400>  5

Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain complementarity determining region

<400>  6

Gly Gly Tyr Thr Met Asp Tyr 
1               5           


<210>  7
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  7

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  8

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  9

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  10
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  10

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  11
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  12
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  12

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Ile Pro 
    50                  55                  60                  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  14
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  14

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  15
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  15

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  16
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  16

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  17

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  18
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  19

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  20
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  20

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  21
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  21

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  22

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  23
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  23

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  24
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  24

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  26
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  26

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  27
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  27

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  28

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  29
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  30
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  30

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  31
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  31

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly 
            100                 105     


<210>  32
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  32
gatgttgtta tgacccaaac tccactctcc ctgtctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaaatac acatgttcct      300

cggacgttcg gccaaggag                                                   319


<210>  33
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  33
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  34
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  34
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc catcaaggtt cagcggcagt ggatctggga cagaattcac tctcaccatc      240

agcagcctgc agcctgatga ttttgcaact tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  35
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  35
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  36
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  36
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc ctaccgattt      180

tctgggatcc cagccaggtt cagtggcagt gggtctggga cagagttcac tctcaccatc      240

agcagcctgc agtctgaaga ttttgcagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  37
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  37
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  38
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  38
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc ctaccgattt      180

tctgggatcc cagccaggtt cagtggcagt gggtctggga cagagttcac tctcaccatc      240

agcagcctgc agtctgaaga ttttgcagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  39
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  39
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  40
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  40
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  41
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  41
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  42
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  42
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  43
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  43
gaaattgtgt tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc cctcgaggtt cagtggcagt ggatctggga cagatttcac ctttaccatc      240

agtagcctgg aagctgaaga tgctgcaaca tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  44
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  44
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  45
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  45
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  46
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  46
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  47
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  47
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc catcaaggtt cagcggcagt ggatctggga cagaattcac tctcaccatc      240

agcagcctgc agcctgatga ttttgcaact tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  48
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  48
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  49
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  49
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  50
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  50
gaaattgtgt tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc cctcgaggtt cagtggcagt ggatctggga cagatttcac ctttaccatc      240

agtagcctgg aagctgaaga tgctgcaaca tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  51
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  51
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  52
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  52
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  53
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  53
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  54
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  54
gaaattgtgt tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc cctcgaggtt cagtggcagt ggatctggga cagatttcac ctttaccatc      240

agtagcctgg aagctgaaga tgctgcaaca tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  55
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  55
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tatcagcaga aaccagggaa agctcctaag ctcctgatct ataaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  56
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  56
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccagcaga aacctggcca ggctcccagg ctcctcatct ataaagtttc ctaccgattt      180

tctggggtcc catcaaggtt cagcggcagt ggatctggga cagaattcac tctcaccatc      240

agcagcctgc agcctgatga ttttgcaact tattactgtt ctcaaaatac acatgttcct      300

cggacgttcg gccaaggg                                                    318


<210>  57
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  57

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  58
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  59
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  59

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  60
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  60

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  61
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  62
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  63
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  63

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  64
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  64

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  65
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  65

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  66
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  66

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  67
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  67

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  68
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  68

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  69
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  69

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  70
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  70

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  71
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  72
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  73
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  74
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  75
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  75

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  76
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  77
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  77

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  78
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  78

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  79
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  79

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  80
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  80

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  81
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  82
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  82
gaggtccagc tgcagcagtt tggggctgaa ctggtgaagc ctggggcttc aatgaagttg       60

tcctgcaagg cttctggcta caccttcacc aactactatg tattctgggt gaaacagagg      120

cctggacaag gccttgagtg gattggagac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacaa ggccacactg actgtagaca agtcctccac cacaacatac      240

ttgcaactca gcagcctgac atctgaggac tctgcggtct attactgtac aagagggggt      300

tatactatgg actactgggg tcaagga                                          327


<210>  83
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable sequence

<400>  83
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  84
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable sequence

<400>  84
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  85
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable sequence

<400>  85
gaagtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  86
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  86
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcagtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggctgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  87
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  87
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcagtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggctgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  88
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  88
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  89
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  89
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  90
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  90
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctggcta caccttcacc aactactatg tattctggat caggcagtcc      120

ccatcgagag gccttgagtg gctgggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  91
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  91
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  92
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  92
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  93
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  93
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  94
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  94
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  95
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  95
gaagtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggcta caccttcacc aactactatg tattctggat caggcagtcc      120

ccatcgagag gccttgagtg gctgggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  96
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  96
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  97
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  97
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  98
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  98
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  99
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  99
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggcta caccttcacc aactactatg tattctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  100
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  100
gaagtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggcta caccttcacc aactactatg tattctggat caggcagtcc      120

ccatcgagag gccttgagtg gctgggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  101
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  101
gaagtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggcta caccttcacc aactactatg tattctggat caggcagtcc      120

ccatcgagag gccttgagtg gctgggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  102
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  102
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctggcta caccttcacc aactactatg tattctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  103
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  103
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  104
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  104
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  105
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  105
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag actcaccatc tccaaggaca cctccaaaaa ccaggtggtc      240

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc aagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  106
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  106
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctggggctac agtgaaaatc       60

tcctgcaagg tttctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccaggga                                          327


<210>  107
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete light chain

<400>  107

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  108
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  complete light chain

<400>  108
gatgttgtta tgacccaaac tccactctcc ctgtctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc ctaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaaatac acatgttcct      300

cggacgttcg gccaagggac caaggtggaa atcaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttga      660


<210>  109
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  109

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  110
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  110

Gly Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Thr Thr Thr Gly Gly Gly Gly Cys Thr Gly Ala Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr 
        35                  40                  45              


Thr Cys Ala Ala Thr Gly Ala Ala Gly Thr Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Ala Cys Thr Ala Cys 
                85                  90                  95      


Thr Ala Thr Gly Thr Ala Thr Thr Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Ala Ala Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Ala Gly Ala Cys Ala Thr Thr Ala Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Thr Cys Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Ala Ala 
                165                 170                 175     


Cys Thr Thr Cys Ala Ala Thr Gly Ala Gly Ala Ala Ala Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Ala Ala Cys Ala Ala Gly Gly Cys Cys Ala Cys Ala Cys 
        195                 200                 205             


Thr Gly Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Ala Gly Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Cys Cys Ala Cys Ala Ala Cys Ala Thr Ala Cys 
225                 230                 235                 240 


Thr Thr Gly Cys Ala Ala Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Thr Cys 
            260                 265                 270         


Thr Gly Cys Gly Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Ala Cys Ala Ala Gly Ala Gly Gly Gly Gly Gly Thr Thr Ala Thr Ala 
    290                 295                 300                 


Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
305                 310                 315                 320 


Cys Cys Ala Gly Gly Gly Ala Ala Cys Gly Cys Thr Gly Gly Thr Cys 
                325                 330                 335     


Ala Cys Cys Gly Thr Cys Ala Gly Cys Thr Cys Ala Gly Cys Cys Thr 
            340                 345                 350         


Cys Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Ala Thr Cys 
        355                 360                 365             


Gly Gly Thr Cys Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly Cys Ala 
    370                 375                 380                 


Cys Cys Cys Thr Cys Cys Thr Cys Cys Ala Ala Gly Ala Gly Cys Ala 
385                 390                 395                 400 


Cys Cys Thr Cys Thr Gly Gly Gly Gly Gly Cys Ala Cys Ala Gly Cys 
                405                 410                 415     


Gly Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr Gly 
            420                 425                 430         


Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys 
        435                 440                 445             


Cys Cys Gly Ala Ala Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr 
    450                 455                 460                 


Gly Thr Cys Gly Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys 
465                 470                 475                 480 


Gly Cys Cys Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys 
            500                 505                 510         


Thr Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala 
        515                 520                 525             


Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys Ala 
    530                 535                 540                 


Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr 
545                 550                 555                 560 


Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys Thr Thr Gly 
                565                 570                 575     


Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala 
            580                 585                 590         


Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Thr Cys Ala 
        595                 600                 605             


Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala Cys Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala Ala Gly 
625                 630                 635                 640 


Thr Thr Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys Thr Thr Gly 
                645                 650                 655     


Thr Gly Ala Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys Ala Cys Ala 
            660                 665                 670         


Thr Gly Cys Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly 
        675                 680                 685             


Cys Ala Cys Cys Thr Gly Ala Ala Cys Thr Cys Cys Thr Gly Gly Gly 
    690                 695                 700                 


Gly Gly Gly Ala Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys 
705                 710                 715                 720 


Cys Thr Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys 
                725                 730                 735     


Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr 
            740                 745                 750         


Gly Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr 
        755                 760                 765             


Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr Gly Gly 
    770                 775                 780                 


Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys Cys Ala 
785                 790                 795                 800 


Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys 
                805                 810                 815     


Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly 
            820                 825                 830         


Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr 
        835                 840                 845             


Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Cys Ala 
    850                 855                 860                 


Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys 
865                 870                 875                 880 


Ala Gly Thr Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys Gly Thr Ala 
                885                 890                 895     


Cys Cys Gly Thr Gly Thr Gly Gly Thr Cys Ala Gly Cys Gly Thr Cys 
            900                 905                 910         


Cys Thr Cys Ala Cys Cys Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys 
        915                 920                 925             


Ala Gly Gly Ala Cys Thr Gly Gly Cys Thr Gly Ala Ala Thr Gly Gly 
    930                 935                 940                 


Cys Ala Ala Gly Gly Ala Gly Thr Ala Cys Ala Ala Gly Thr Gly Cys 
945                 950                 955                 960 


Ala Ala Gly Gly Thr Cys Ala Gly Cys Ala Ala Cys Ala Ala Ala Gly 
                965                 970                 975     


Cys Cys Cys Thr Cys Cys Cys Ala Gly Cys Cys Cys Cys Cys Ala Thr 
            980                 985                 990         


Cys Gly Ala Gly Ala Ala Ala Ala  Cys Cys Ala Thr Cys  Thr Cys Cys 
        995                 1000                 1005             


Ala Ala  Ala Gly Cys Cys Ala  Ala Ala Gly Gly Gly  Cys Ala Gly 
    1010                 1015                 1020             


Cys Cys  Cys Cys Gly Ala Gly  Ala Ala Cys Cys Ala  Cys Ala Gly 
    1025                 1030                 1035             


Gly Thr  Gly Thr Ala Cys Ala  Cys Cys Cys Thr Gly  Cys Cys Cys 
    1040                 1045                 1050             


Cys Cys  Ala Thr Cys Cys Cys  Gly Gly Gly Ala Thr  Gly Ala Gly 
    1055                 1060                 1065             


Cys Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Cys  Cys Ala Gly 
    1070                 1075                 1080             


Gly Thr  Cys Ala Gly Cys Cys  Thr Gly Ala Cys Cys  Thr Gly Cys 
    1085                 1090                 1095             


Cys Thr  Gly Gly Thr Cys Ala  Ala Ala Gly Gly Cys  Thr Thr Cys 
    1100                 1105                 1110             


Thr Ala  Thr Cys Cys Cys Ala  Gly Cys Gly Ala Cys  Ala Thr Cys 
    1115                 1120                 1125             


Gly Cys  Cys Gly Thr Gly Gly  Ala Gly Thr Gly Gly  Gly Ala Gly 
    1130                 1135                 1140             


Ala Gly  Cys Ala Ala Thr Gly  Gly Gly Cys Ala Gly  Cys Cys Gly 
    1145                 1150                 1155             


Gly Ala  Gly Ala Ala Cys Ala  Ala Cys Thr Ala Cys  Ala Ala Gly 
    1160                 1165                 1170             


Ala Cys  Cys Ala Cys Gly Cys  Cys Thr Cys Cys Cys  Gly Thr Gly 
    1175                 1180                 1185             


Cys Thr  Gly Gly Ala Cys Thr  Cys Cys Gly Ala Cys  Gly Gly Cys 
    1190                 1195                 1200             


Thr Cys  Cys Thr Thr Cys Thr  Thr Cys Cys Thr Cys  Thr Ala Cys 
    1205                 1210                 1215             


Ala Gly  Cys Ala Ala Gly Cys  Thr Cys Ala Cys Cys  Gly Thr Gly 
    1220                 1225                 1230             


Gly Ala  Cys Ala Ala Gly Ala  Gly Cys Ala Gly Gly  Thr Gly Gly 
    1235                 1240                 1245             


Cys Ala  Gly Cys Ala Gly Gly  Gly Gly Ala Ala Cys  Gly Thr Cys 
    1250                 1255                 1260             


Thr Thr  Cys Thr Cys Ala Thr  Gly Cys Thr Cys Cys  Gly Thr Gly 
    1265                 1270                 1275             


Ala Thr  Gly Cys Ala Thr Gly  Ala Gly Gly Cys Thr  Cys Thr Gly 
    1280                 1285                 1290             


Cys Ala  Cys Ala Ala Cys Cys  Ala Cys Thr Ala Cys  Ala Cys Gly 
    1295                 1300                 1305             


Cys Ala  Gly Ala Ala Gly Ala  Gly Cys Cys Thr Cys  Thr Cys Cys 
    1310                 1315                 1320             


Cys Thr  Gly Thr Cys Thr Cys  Cys Gly Gly Gly Thr  Ala Ala Ala 
    1325                 1330                 1335             


Thr Gly  Ala 
    1340     


<210>  111
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  111

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg 
        


<210>  112
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  113
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  113

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  114
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  114

Gly Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Thr Thr Thr Gly Gly Gly Gly Cys Thr Gly Ala Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr 
        35                  40                  45              


Thr Cys Ala Ala Thr Gly Ala Ala Gly Thr Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Ala Cys Thr Ala Cys 
                85                  90                  95      


Thr Ala Thr Gly Thr Ala Thr Thr Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Ala Ala Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Ala Gly Ala Cys Ala Thr Thr Ala Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Thr Cys Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Ala Ala 
                165                 170                 175     


Cys Thr Thr Cys Ala Ala Thr Gly Ala Gly Ala Ala Ala Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Ala Ala Cys Ala Ala Gly Gly Cys Cys Ala Cys Ala Cys 
        195                 200                 205             


Thr Gly Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Ala Gly Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Cys Cys Ala Cys Ala Ala Cys Ala Thr Ala Cys 
225                 230                 235                 240 


Thr Thr Gly Cys Ala Ala Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Thr Cys 
            260                 265                 270         


Thr Gly Cys Gly Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Ala Cys Ala Ala Gly Ala Gly Gly Gly Gly Gly Thr Thr Ala Thr Ala 
    290                 295                 300                 


Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
305                 310                 315                 320 


Cys Cys Ala Gly Gly Gly Ala Ala Cys Gly Cys Thr Gly Gly Thr Cys 
                325                 330                 335     


Ala Cys Cys Gly Thr Cys Ala Gly Cys Thr Cys Ala Gly Cys Cys Thr 
            340                 345                 350         


Cys Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Ala Thr Cys 
        355                 360                 365             


Gly Gly Thr Cys Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly Cys Ala 
    370                 375                 380                 


Cys Cys Cys Thr Cys Cys Thr Cys Cys Ala Ala Gly Ala Gly Cys Ala 
385                 390                 395                 400 


Cys Cys Thr Cys Thr Gly Gly Gly Gly Gly Cys Ala Cys Ala Gly Cys 
                405                 410                 415     


Gly Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr Gly 
            420                 425                 430         


Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys 
        435                 440                 445             


Cys Cys Gly Ala Ala Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr 
    450                 455                 460                 


Gly Thr Cys Gly Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys 
465                 470                 475                 480 


Gly Cys Cys Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys 
            500                 505                 510         


Thr Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala 
        515                 520                 525             


Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys Ala 
    530                 535                 540                 


Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr 
545                 550                 555                 560 


Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys Thr Thr Gly 
                565                 570                 575     


Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala 
            580                 585                 590         


Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Thr Cys Ala 
        595                 600                 605             


Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala Cys Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala Ala Gly 
625                 630                 635                 640 


Thr Thr Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys Thr Thr Gly 
                645                 650                 655     


Thr Gly Ala Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys Ala Cys Ala 
            660                 665                 670         


Thr Gly Cys Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly 
        675                 680                 685             


Cys Ala Cys Cys Thr Gly Ala Ala Cys Thr Cys Cys Thr Gly Gly Gly 
    690                 695                 700                 


Gly Gly Gly Ala Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys 
705                 710                 715                 720 


Cys Thr Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys 
                725                 730                 735     


Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr 
            740                 745                 750         


Gly Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr 
        755                 760                 765             


Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr Gly Gly 
    770                 775                 780                 


Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys Cys Ala 
785                 790                 795                 800 


Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys 
                805                 810                 815     


Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly 
            820                 825                 830         


Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr 
        835                 840                 845             


Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Cys Ala 
    850                 855                 860                 


Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys 
865                 870                 875                 880 


Ala Gly Thr Ala Cys Cys Ala Gly Ala Gly Cys Ala Cys Gly Thr Ala 
                885                 890                 895     


Cys Cys Gly Thr Gly Thr Gly Gly Thr Cys Ala Gly Cys Gly Thr Cys 
            900                 905                 910         


Cys Thr Cys Ala Cys Cys Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys 
        915                 920                 925             


Ala Gly Gly Ala Cys Thr Gly Gly Cys Thr Gly Ala Ala Thr Gly Gly 
    930                 935                 940                 


Cys Ala Ala Gly Gly Ala Gly Thr Ala Cys Ala Ala Gly Thr Gly Cys 
945                 950                 955                 960 


Ala Ala Gly Gly Thr Cys Ala Gly Cys Ala Ala Cys Ala Ala Ala Gly 
                965                 970                 975     


Cys Cys Cys Thr Cys Cys Cys Ala Gly Cys Cys Cys Cys Cys Ala Thr 
            980                 985                 990         


Cys Gly Ala Gly Ala Ala Ala Ala  Cys Cys Ala Thr Cys  Thr Cys Cys 
        995                 1000                 1005             


Ala Ala  Ala Gly Cys Cys Ala  Ala Ala Gly Gly Gly  Cys Ala Gly 
    1010                 1015                 1020             


Cys Cys  Cys Cys Gly Ala Gly  Ala Ala Cys Cys Ala  Cys Ala Gly 
    1025                 1030                 1035             


Gly Thr  Gly Thr Ala Cys Ala  Cys Cys Cys Thr Gly  Cys Cys Cys 
    1040                 1045                 1050             


Cys Cys  Ala Thr Cys Cys Cys  Gly Gly Gly Ala Thr  Gly Ala Gly 
    1055                 1060                 1065             


Cys Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Cys  Cys Ala Gly 
    1070                 1075                 1080             


Gly Thr  Cys Ala Gly Cys Cys  Thr Gly Ala Cys Cys  Thr Gly Cys 
    1085                 1090                 1095             


Cys Thr  Gly Gly Thr Cys Ala  Ala Ala Gly Gly Cys  Thr Thr Cys 
    1100                 1105                 1110             


Thr Ala  Thr Cys Cys Cys Ala  Gly Cys Gly Ala Cys  Ala Thr Cys 
    1115                 1120                 1125             


Gly Cys  Cys Gly Thr Gly Gly  Ala Gly Thr Gly Gly  Gly Ala Gly 
    1130                 1135                 1140             


Ala Gly  Cys Ala Ala Thr Gly  Gly Gly Cys Ala Gly  Cys Cys Gly 
    1145                 1150                 1155             


Gly Ala  Gly Ala Ala Cys Ala  Ala Cys Thr Ala Cys  Ala Ala Gly 
    1160                 1165                 1170             


Ala Cys  Cys Ala Cys Gly Cys  Cys Thr Cys Cys Cys  Gly Thr Gly 
    1175                 1180                 1185             


Cys Thr  Gly Gly Ala Cys Thr  Cys Cys Gly Ala Cys  Gly Gly Cys 
    1190                 1195                 1200             


Thr Cys  Cys Thr Thr Cys Thr  Thr Cys Cys Thr Cys  Thr Ala Cys 
    1205                 1210                 1215             


Ala Gly  Cys Ala Ala Gly Cys  Thr Cys Ala Cys Cys  Gly Thr Gly 
    1220                 1225                 1230             


Gly Ala  Cys Ala Ala Gly Ala  Gly Cys Ala Gly Gly  Thr Gly Gly 
    1235                 1240                 1245             


Cys Ala  Gly Cys Ala Gly Gly  Gly Gly Ala Ala Cys  Gly Thr Cys 
    1250                 1255                 1260             


Thr Thr  Cys Thr Cys Ala Thr  Gly Cys Thr Cys Cys  Gly Thr Gly 
    1265                 1270                 1275             


Ala Thr  Gly Cys Ala Thr Gly  Ala Gly Gly Cys Thr  Cys Thr Gly 
    1280                 1285                 1290             


Cys Ala  Cys Ala Ala Cys Cys  Ala Cys Thr Ala Cys  Ala Cys Gly 
    1295                 1300                 1305             


Cys Ala  Gly Ala Ala Gly Ala  Gly Cys Cys Thr Cys  Thr Cys Cys 
    1310                 1315                 1320             


Cys Thr  Gly Thr Cys Thr Cys  Cys Gly Gly Gly Thr  Ala Ala Ala 
    1325                 1330                 1335             


Thr Gly  Ala 
    1340     


<210>  115
<211>  1326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  115

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Thr Cys Ala Cys Ala Gly 
        35                  40                  45              


Ala Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Ala Cys Thr Ala Cys 
                85                  90                  95      


Thr Ala Thr Gly Thr Ala Thr Thr Cys Thr Gly Gly Gly Thr Gly Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Thr Cys Gly Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Cys Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Ala 
    130                 135                 140                 


Gly Gly Thr Gly Ala Cys Ala Thr Thr Ala Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Thr Cys Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Ala Ala 
                165                 170                 175     


Cys Thr Thr Cys Ala Ala Thr Gly Ala Gly Ala Ala Ala Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Ala Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Ala Gly Cys Cys Gly Ala Cys Ala Ala Gly Thr Cys 
    210                 215                 220                 


Cys Ala Thr Cys Ala Gly Cys Ala Cys Cys Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Thr Gly Gly Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Ala Gly Gly Cys Cys Thr Cys Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Ala Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Gly Ala Gly Ala Gly Gly Gly Gly Gly Thr Thr Ala Thr Ala 
    290                 295                 300                 


Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
305                 310                 315                 320 


Cys Cys Ala Gly Gly Gly Ala Ala Cys Gly Cys Thr Gly Gly Thr Cys 
                325                 330                 335     


Ala Cys Cys Gly Thr Cys Ala Gly Cys Thr Cys Ala Gly Cys Cys Thr 
            340                 345                 350         


Cys Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Ala Thr Cys 
        355                 360                 365             


Gly Gly Thr Cys Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly Cys Ala 
    370                 375                 380                 


Cys Cys Cys Thr Gly Cys Thr Cys Cys Ala Gly Gly Ala Gly Cys Ala 
385                 390                 395                 400 


Cys Cys Thr Cys Cys Gly Ala Gly Ala Gly Cys Ala Cys Ala Gly Cys 
                405                 410                 415     


Gly Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr Gly 
            420                 425                 430         


Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys 
        435                 440                 445             


Cys Cys Gly Ala Ala Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr 
    450                 455                 460                 


Gly Thr Cys Gly Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys 
465                 470                 475                 480 


Gly Cys Thr Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys 
            500                 505                 510         


Thr Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala 
        515                 520                 525             


Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys Ala 
    530                 535                 540                 


Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr 
545                 550                 555                 560 


Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Ala Cys Thr Thr Cys 
                565                 570                 575     


Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala 
            580                 585                 590         


Cys Cys Thr Gly Cys Ala Ala Cys Gly Thr Ala Gly Ala Thr Cys Ala 
        595                 600                 605             


Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala Cys Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Cys Ala Gly 
625                 630                 635                 640 


Thr Thr Gly Ala Gly Cys Gly Cys Ala Ala Ala Thr Gly Thr Thr Gly 
                645                 650                 655     


Thr Gly Thr Cys Gly Ala Gly Thr Gly Cys Cys Cys Ala Cys Cys Gly 
            660                 665                 670         


Thr Gly Cys Cys Cys Ala Gly Cys Ala Cys Cys Ala Cys Cys Thr Gly 
        675                 680                 685             


Thr Gly Gly Cys Ala Gly Gly Ala Cys Cys Gly Thr Cys Ala Gly Thr 
    690                 695                 700                 


Cys Thr Thr Cys Cys Thr Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala 
705                 710                 715                 720 


Ala Ala Ala Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys 
                725                 730                 735     


Thr Cys Ala Thr Gly Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys 
            740                 745                 750         


Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Cys Gly Thr Gly Cys 
        755                 760                 765             


Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala 
    770                 775                 780                 


Gly Cys Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Cys Gly Ala 
785                 790                 795                 800 


Gly Gly Thr Cys Cys Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly 
                805                 810                 815     


Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly 
            820                 825                 830         


Ala Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala 
        835                 840                 845             


Gly Ala Cys Ala Ala Ala Gly Cys Cys Ala Cys Gly Gly Gly Ala Gly 
    850                 855                 860                 


Gly Ala Gly Cys Ala Gly Thr Thr Cys Ala Ala Cys Ala Gly Cys Ala 
865                 870                 875                 880 


Cys Gly Thr Thr Cys Cys Gly Thr Gly Thr Gly Gly Thr Cys Ala Gly 
                885                 890                 895     


Cys Gly Thr Cys Cys Thr Cys Ala Cys Cys Gly Thr Cys Gly Thr Gly 
            900                 905                 910         


Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr Gly Gly Cys Thr Gly Ala 
        915                 920                 925             


Ala Cys Gly Gly Cys Ala Ala Gly Gly Ala Gly Thr Ala Cys Ala Ala 
    930                 935                 940                 


Gly Thr Gly Cys Ala Ala Gly Gly Thr Gly Thr Cys Cys Ala Ala Cys 
945                 950                 955                 960 


Ala Ala Ala Gly Gly Cys Cys Thr Cys Cys Cys Ala Gly Cys Cys Cys 
                965                 970                 975     


Cys Cys Ala Thr Cys Gly Ala Gly Ala Ala Ala Ala Cys Cys Ala Thr 
            980                 985                 990         


Cys Thr Cys Cys Ala Ala Ala Ala  Cys Cys Ala Ala Ala  Gly Gly Gly 
        995                 1000                 1005             


Cys Ala  Gly Cys Cys Cys Cys  Gly Ala Gly Ala Ala  Cys Cys Ala 
    1010                 1015                 1020             


Cys Ala  Gly Gly Thr Gly Thr  Ala Cys Ala Cys Cys  Cys Thr Gly 
    1025                 1030                 1035             


Cys Cys  Cys Cys Cys Ala Thr  Cys Cys Cys Gly Gly  Gly Ala Gly 
    1040                 1045                 1050             


Gly Ala  Gly Ala Thr Gly Ala  Cys Cys Ala Ala Gly  Ala Ala Cys 
    1055                 1060                 1065             


Cys Ala  Gly Gly Thr Cys Ala  Gly Cys Cys Thr Gly  Ala Cys Cys 
    1070                 1075                 1080             


Thr Gly  Cys Cys Thr Gly Gly  Thr Cys Ala Ala Ala  Gly Gly Cys 
    1085                 1090                 1095             


Thr Thr  Cys Thr Ala Cys Cys  Cys Cys Ala Gly Cys  Gly Ala Cys 
    1100                 1105                 1110             


Ala Thr  Cys Gly Cys Cys Gly  Thr Gly Gly Ala Gly  Thr Gly Gly 
    1115                 1120                 1125             


Gly Ala  Gly Ala Gly Cys Ala  Ala Thr Gly Gly Gly  Cys Ala Gly 
    1130                 1135                 1140             


Cys Cys  Gly Gly Ala Gly Ala  Ala Cys Ala Ala Cys  Thr Ala Cys 
    1145                 1150                 1155             


Ala Ala  Cys Ala Cys Cys Ala  Cys Ala Cys Cys Thr  Cys Cys Cys 
    1160                 1165                 1170             


Ala Thr  Gly Cys Thr Gly Gly  Ala Cys Thr Cys Cys  Gly Ala Cys 
    1175                 1180                 1185             


Gly Gly  Cys Thr Cys Cys Thr  Thr Cys Thr Thr Cys  Cys Thr Cys 
    1190                 1195                 1200             


Thr Ala  Cys Ala Gly Cys Ala  Ala Gly Cys Thr Cys  Ala Cys Cys 
    1205                 1210                 1215             


Gly Thr  Gly Gly Ala Cys Ala  Ala Gly Ala Gly Cys  Ala Gly Gly 
    1220                 1225                 1230             


Thr Gly  Gly Cys Ala Gly Cys  Ala Gly Gly Gly Gly  Ala Ala Cys 
    1235                 1240                 1245             


Gly Thr  Cys Thr Thr Cys Thr  Cys Ala Thr Gly Cys  Thr Cys Cys 
    1250                 1255                 1260             


Gly Thr  Gly Ala Thr Gly Cys  Ala Thr Gly Ala Gly  Gly Cys Thr 
    1265                 1270                 1275             


Cys Thr  Gly Cys Ala Cys Ala  Ala Cys Cys Ala Cys  Thr Ala Cys 
    1280                 1285                 1290             


Ala Cys  Gly Cys Ala Gly Ala  Ala Gly Ala Gly Cys  Cys Thr Cys 
    1295                 1300                 1305             


Thr Cys  Cys Cys Thr Gly Thr  Cys Thr Cys Cys Gly  Gly Gly Thr 
    1310                 1315                 1320             


Ala Ala  Ala 
    1325     


<210>  116
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete heavy chain

<400>  116

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Ala Gly Cys Cys Thr Thr Cys Ala Cys Ala Gly 
        35                  40                  45              


Ala Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Ala Cys Thr Ala Cys 
                85                  90                  95      


Thr Ala Thr Gly Thr Ala Thr Thr Cys Thr Gly Gly Gly Thr Gly Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Thr Cys Gly Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Cys Gly Cys Cys Thr Thr Gly Ala Gly Thr Gly Gly Ala Thr Ala 
    130                 135                 140                 


Gly Gly Thr Gly Ala Cys Ala Thr Thr Ala Ala Thr Cys Cys Thr Gly 
145                 150                 155                 160 


Thr Cys Ala Ala Thr Gly Gly Thr Gly Ala Thr Ala Cys Thr Ala Ala 
                165                 170                 175     


Cys Thr Thr Cys Ala Ala Thr Gly Ala Gly Ala Ala Ala Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Ala Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Ala Gly Cys Cys Gly Ala Cys Ala Ala Gly Thr Cys 
    210                 215                 220                 


Cys Ala Thr Cys Ala Gly Cys Ala Cys Cys Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Thr Gly Gly Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Ala Gly Gly Cys Cys Thr Cys Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Ala Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Gly Ala Gly Ala Gly Gly Gly Gly Gly Thr Thr Ala Thr Ala 
    290                 295                 300                 


Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
305                 310                 315                 320 


Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Cys Cys Gly Thr Gly 
                325                 330                 335     


Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Cys Cys Gly Cys Thr Thr 
            340                 345                 350         


Cys Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Ala Thr Cys 
        355                 360                 365             


Cys Gly Thr Cys Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly Cys Gly 
    370                 375                 380                 


Cys Cys Cys Thr Gly Cys Thr Cys Cys Ala Gly Gly Ala Gly Cys Ala 
385                 390                 395                 400 


Cys Cys Thr Cys Cys Gly Ala Gly Ala Gly Cys Ala Cys Ala Gly Cys 
                405                 410                 415     


Cys Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr Gly 
            420                 425                 430         


Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys 
        435                 440                 445             


Cys Cys Gly Ala Ala Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr 
    450                 455                 460                 


Gly Thr Cys Gly Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys 
465                 470                 475                 480 


Gly Cys Cys Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys 
            500                 505                 510         


Thr Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala 
        515                 520                 525             


Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys Ala 
    530                 535                 540                 


Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr 
545                 550                 555                 560 


Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys Thr Thr Gly 
                565                 570                 575     


Gly Gly Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Thr Ala Cys Ala 
            580                 585                 590         


Cys Cys Thr Gly Cys Ala Ala Cys Gly Thr Ala Gly Ala Thr Cys Ala 
        595                 600                 605             


Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala Cys Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly Ala Gly 
625                 630                 635                 640 


Thr Thr Gly Ala Gly Thr Cys Cys Ala Ala Ala Thr Ala Thr Gly Gly 
                645                 650                 655     


Thr Cys Cys Cys Cys Cys Ala Thr Gly Cys Cys Cys Ala Cys Cys Gly 
            660                 665                 670         


Thr Gly Cys Cys Cys Ala Gly Cys Ala Cys Cys Thr Gly Ala Gly Thr 
        675                 680                 685             


Thr Cys Cys Thr Gly Gly Gly Gly Gly Gly Ala Cys Cys Ala Thr Cys 
    690                 695                 700                 


Ala Gly Thr Cys Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys Cys 
705                 710                 715                 720 


Cys Cys Ala Ala Ala Ala Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala 
                725                 730                 735     


Cys Thr Cys Thr Cys Ala Thr Gly Ala Thr Cys Thr Cys Cys Cys Gly 
            740                 745                 750         


Gly Ala Cys Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Cys Gly 
        755                 760                 765             


Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly 
    770                 775                 780                 


Thr Gly Ala Gly Cys Cys Ala Gly Gly Ala Ala Gly Ala Cys Cys Cys 
785                 790                 795                 800 


Cys Gly Ala Gly Gly Thr Cys Cys Ala Gly Thr Thr Cys Ala Ala Cys 
                805                 810                 815     


Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Thr Gly Gly Cys Gly 
            820                 825                 830         


Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys 
        835                 840                 845             


Cys Ala Ala Gly Ala Cys Ala Ala Ala Gly Cys Cys Gly Cys Gly Gly 
    850                 855                 860                 


Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Thr Cys Ala Ala Cys Ala 
865                 870                 875                 880 


Gly Cys Ala Cys Gly Thr Ala Cys Cys Gly Thr Gly Thr Gly Gly Thr 
                885                 890                 895     


Cys Ala Gly Cys Gly Thr Cys Cys Thr Cys Ala Cys Cys Gly Thr Cys 
            900                 905                 910         


Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr Gly Gly Cys 
        915                 920                 925             


Thr Gly Ala Ala Cys Gly Gly Cys Ala Ala Gly Gly Ala Gly Thr Ala 
    930                 935                 940                 


Cys Ala Ala Gly Thr Gly Cys Ala Ala Gly Gly Thr Gly Thr Cys Cys 
945                 950                 955                 960 


Ala Ala Cys Ala Ala Ala Gly Gly Cys Cys Thr Cys Cys Cys Gly Thr 
                965                 970                 975     


Cys Cys Thr Cys Cys Ala Thr Cys Gly Ala Gly Ala Ala Ala Ala Cys 
            980                 985                 990         


Cys Ala Thr Cys Thr Cys Cys Ala  Ala Ala Gly Cys Cys  Ala Ala Ala 
        995                 1000                 1005             


Gly Gly  Gly Cys Ala Gly Cys  Cys Cys Cys Gly Ala  Gly Ala Gly 
    1010                 1015                 1020             


Cys Cys  Ala Cys Ala Gly Gly  Thr Gly Thr Ala Cys  Ala Cys Cys 
    1025                 1030                 1035             


Cys Thr  Gly Cys Cys Cys Cys  Cys Ala Thr Cys Cys  Cys Ala Gly 
    1040                 1045                 1050             


Gly Ala  Gly Gly Ala Gly Ala  Thr Gly Ala Cys Cys  Ala Ala Gly 
    1055                 1060                 1065             


Ala Ala  Cys Cys Ala Gly Gly  Thr Cys Ala Gly Cys  Cys Thr Gly 
    1070                 1075                 1080             


Ala Cys  Cys Thr Gly Cys Cys  Thr Gly Gly Thr Cys  Ala Ala Ala 
    1085                 1090                 1095             


Gly Gly  Cys Thr Thr Cys Thr  Ala Cys Cys Cys Cys  Ala Gly Cys 
    1100                 1105                 1110             


Gly Ala  Cys Ala Thr Cys Gly  Cys Cys Gly Thr Gly  Gly Ala Gly 
    1115                 1120                 1125             


Thr Gly  Gly Gly Ala Gly Ala  Gly Cys Ala Ala Thr  Gly Gly Gly 
    1130                 1135                 1140             


Cys Ala  Gly Cys Cys Gly Gly  Ala Gly Ala Ala Cys  Ala Ala Cys 
    1145                 1150                 1155             


Thr Ala  Cys Ala Ala Gly Ala  Cys Cys Ala Cys Gly  Cys Cys Thr 
    1160                 1165                 1170             


Cys Cys  Cys Gly Thr Gly Cys  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1175                 1180                 1185             


Gly Ala  Cys Gly Gly Cys Thr  Cys Cys Thr Thr Cys  Thr Thr Cys 
    1190                 1195                 1200             


Cys Thr  Cys Thr Ala Cys Ala  Gly Cys Ala Gly Gly  Cys Thr Ala 
    1205                 1210                 1215             


Ala Cys  Cys Gly Thr Gly Gly  Ala Cys Ala Ala Gly  Ala Gly Cys 
    1220                 1225                 1230             


Ala Gly  Gly Thr Gly Gly Cys  Ala Gly Gly Ala Gly  Gly Gly Gly 
    1235                 1240                 1245             


Ala Ala  Thr Gly Thr Cys Thr  Thr Cys Thr Cys Ala  Thr Gly Cys 
    1250                 1255                 1260             


Thr Cys  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Thr  Gly Ala Gly 
    1265                 1270                 1275             


Gly Cys  Thr Cys Thr Gly Cys  Ala Cys Ala Ala Cys  Cys Ala Cys 
    1280                 1285                 1290             


Thr Ala  Cys Ala Cys Ala Cys  Ala Gly Ala Ala Gly  Ala Gly Cys 
    1295                 1300                 1305             


Cys Thr  Cys Thr Cys Cys Cys  Thr Gly Thr Cys Thr  Cys Thr Gly 
    1310                 1315                 1320             


Gly Gly  Thr Ala Ala Ala 
    1325                 


<210>  117
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain constant region

<400>  117

Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
1               5                   10                  15      


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            20                  25                  30          


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        35                  40                  45              


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    50                  55                  60                  


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
65                  70                  75                  80  


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                85                  90                  95      


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105                 110         


Cys 
    


<210>  118
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  118

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            20                  25                  30          


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                85                  90                  95      


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            100                 105                 110         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        275                 280                 285             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     


Lys 
    


<210>  119
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  119

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            20                  25                  30          


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                85                  90                  95      


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            100                 105                 110         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg 
                245 


<210>  120
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  120

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
1               5                   10                  15      


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
            20                  25                  30          


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        35                  40                  45              


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    50                  55                  60                  


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
65                  70                  75                  80  


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
                85                  90                  95      


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
            100                 105                 110         


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu 
        275                 280                 285             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     


Lys 
    


<210>  121
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain constant region

<400>  121

Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
            20                  25                  30          


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
                85                  90                  95      


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
            100                 105                 110         


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                165                 170                 175     


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        195                 200                 205             


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    210                 215                 220                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
225                 230                 235                 240 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                245                 250                 255     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            260                 265                 270         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    290                 295                 300                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                325                 330                 


<210>  122
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length heavy chain variable domain and a constant domain 
       amino acid sequence.

<400>  122

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val Phe Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Val Asn Gly Asp Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  123
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 S228P L235E Heavy Chain Nucleic Acid Sequence

<400>  123
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggcta caccttcacc aactactatg tattctgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggtgac attaatcctg tcaatggtga tactaacttc      180

aatgagaaat tcaagaacag agtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagagggggt      300

tatactatgg actactgggg ccagggcacc accgtgaccg tgtcctccgc ttccaccaag      360

ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac      600

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttgagtccaa atatggtccc      660

ccatgcccac cgtgcccagc acctgagttc gaggggggac catcagtctt cctgttcccc      720

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      780

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgtcc      960

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1320

ctgggtaaa                                                             1329


<210>  124
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4 + Heavy Chain Constant IgG4 S228P L235E Domain

<400>  124

Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
            20                  25                  30          


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
                85                  90                  95      


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
            100                 105                 110         


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                165                 170                 175     


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        195                 200                 205             


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    210                 215                 220                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
225                 230                 235                 240 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                245                 250                 255     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            260                 265                 270         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    290                 295                 300                 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                325                 330                 



