                         SEQUENCE LISTING

<110>  The Arizona Board of Regents on Behalf of The University of
        Arizona
 
<120>  NOVEL MODULATORS OF MELANOCORTIN RECEPTORS

<130>  UNIA 14.05 PCT

<140>  PCT/US15/35180
<141>  2015-06-10

<150>  62/017,137
<151>  2014-06-25

<150>  14/300,991
<151>  2014-06-10

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic SHU-9119 peptide, an agonist for the hMC1R and hMC5R 
       and an antagonist for the hMC3R and hMC4R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<400>  1

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  2

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  nal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  3

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<400>  4

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<400>  5

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<400>  6

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  7

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  8

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  9

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  10

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  11

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  12

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  13

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<400>  14

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<400>  15

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<400>  16

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  17

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  18

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  19

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  20

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  21

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  22

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  23

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  24

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  25

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<400>  26

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  27

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  28

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  29

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  30

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<400>  31

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modifed derivative of SHU9119


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-Nal(2')

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  N-methylation

<400>  32

Leu Asp His Xaa Arg Trp Lys 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic MT-II peptide, a universal agonist for all the hMCR


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  cyclic

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D amino acid

<400>  33

Leu Asp His Phe Arg Trp Lys 
1               5           


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified hMCR peptide ligand

<400>  34

His Phe Arg Trp 
1               


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified peptide ligand


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  hex-5-ynoyl

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  DNal(2')

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  D amino acid

<400>  35

Lys Tyr Val Leu Gly His Xaa Arg Trp Asp Arg Phe Gly 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified peptide ligand


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  hex-5-ynoyl

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  DNal(2')

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  D amino acid

<400>  36

Lys Tyr Val Leu Gly His Xaa Arg Phe Asp Arg Phe Gly 
1               5                   10              


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified peptide ligand


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  DNal(2')

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  D amino acid

<400>  37

Tyr Val Leu Gly His Xaa Arg Trp Asp Arg Phe Gly 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified peptide ligand


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Norleucine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  DNal(2')

<400>  38

Tyr Val Leu Gly His Phe Arg Xaa Asp Arg Phe Gly 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified peptide ligand


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  DNal(2')

<400>  39

Tyr Val Leu Gly His Phe Arg Xaa Asp Arg Phe Gly 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified peptide ligand


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  DNal(2')

<400>  40

Tyr Val Ile Gly His Phe Arg Xaa Asp Arg Phe Gly 
1               5                   10          


