                         SEQUENCE LISTING

<110>  PolyBioCept AB
 
<120>  EXPANSION OF LYMPHOCYTES WITH A CYTOKINE COMPOSITION FOR ACTIVE 
       CELLULAR IMMUNOTHERAPY

<130>  7027/P/1003-WO

<150>  DE 10 2014 211 167.6
<151>  2014-06-11

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  2
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  3
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe Leu Gly Thr Leu 
1               5                   10                  15      


Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg Met 
            20                  25                  30          


Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn Asp 
        35                  40                  45              


Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn Cys 
    50                  55                  60                  


Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala 
65                  70                  75                  80  


Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys Leu 
                85                  90                  95      


Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His Arg 
            100                 105                 110         


Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser 
145                 150                 155 


<210>  4
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  5
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  6
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  7
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  8
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly 
1               5                   10                  15      


Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr 
            20                  25                  30          


Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val 
        35                  40                  45              


Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp 
    50                  55                  60                  


Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr 
65                  70                  75                  80  


Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn 
                85                  90                  95      


Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr 
            100                 105                 110         


Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val 
        115                 120                 125             


His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val 
    130                 135                 140                 


Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg 
145                 150                 155                 160 


Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys 
                165                 170                 175     


Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp 
            180                 185                 190         


Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met 
        195                 200                 205             


Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val 
    210                 215                 220                 


Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu 
225                 230                 235                 240 


Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met 
                245                 250                 255     


Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe 
            260                 265                 270         


Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser 
        275                 280                 285             


His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu 
    290                 295                 300                 


Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu 
305                 310                 315                 320 


Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr 
                325                 330                 335     


Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp 
            340                 345                 350         


Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr 
        355                 360                 365             


Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr 
    370                 375                 380                 


Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp 
385                 390                 395                 400 


Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Arg Lys 
                405                 410                 415     


Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser 
            420                 425                 430         


Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser 
        435                 440                 445             


Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro 
    450                 455                 460                 


Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala 
465                 470                 475                 480 


Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu 
                485                 490                 495     


Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr 
            500                 505                 510 


<210>  9
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Lys Asp Arg Pro Gly Pro Pro Ala Leu Asp Asp Asn Met Glu 
1               5                   10                  15      


Glu Glu Val Pro Ser Thr Ser Val Val Gln Glu Gln Val Ser Ala Gly 
            20                  25                  30          


Asp Trp Glu Asn Val Leu Ile Glu Leu Ser Asp Ser Ser Ser Glu Lys 
        35                  40                  45              


Glu Ala Glu Asp Ala His Leu Glu Pro Ala Gln Lys Gly Thr Lys Arg 
    50                  55                  60                  


Lys Arg Val Asp His Asp Ala Gly Gly Ser Ala Pro Ala Arg Pro Met 
65                  70                  75                  80  


Leu Pro Pro Gln Pro Asp Leu Pro Gly Arg Glu Ala Ile Leu Arg Arg 
                85                  90                  95      


Phe Pro Leu Asp Leu Arg Thr Leu Leu Gln Ala Ile Gly Ala Ala Ala 
            100                 105                 110         


Thr Arg Ile Asp Thr Arg Ala Ile Asp Gln Phe Phe Gly Ser Gln Ile 
        115                 120                 125             


Ser Asn Thr Glu Met Tyr Ile Met Tyr Ala Met Ala Ile Arg Gln Ala 
    130                 135                 140                 


Ile Arg Asp Arg Arg Arg Asn Pro Ala Ser Arg Arg Asp Gln Ala Lys 
145                 150                 155                 160 


Trp Arg Leu Gln Thr Leu Ala Ala Gly Trp Pro Met Gly Tyr Gln Ala 
                165                 170                 175     


Tyr Ser Ser Trp Met Tyr Ser Tyr Thr Asp His Gln Thr Thr Pro Thr 
            180                 185                 190         


Phe Val His Leu Gln Ala Thr Leu Gly Cys Thr Gly Gly Arg Arg Cys 
        195                 200                 205             


His Val Thr Phe Ser Ala Gly Thr Phe Lys Leu Pro Arg Cys Thr Pro 
    210                 215                 220                 


Gly Asp Arg Gln Trp Leu Tyr Val Gln Ser Ser Val Gly Asn Ile Val 
225                 230                 235                 240 


Gln Ser Cys Asn Pro Arg Tyr Ser Ile Phe Phe Asp Tyr Met Ala Ile 
                245                 250                 255     


His Arg Ser Leu Thr Lys Ile Trp Glu Glu Val Leu Thr Pro Asp Gln 
            260                 265                 270         


Arg Val Ser Phe Met Glu Phe Leu Gly Phe Leu Gln Arg Thr Asp Leu 
        275                 280                 285             


Ser Tyr Ile Lys Ser Phe Val Ser Asp Ala Leu Gly Thr Thr Ser Ile 
    290                 295                 300                 


Gln Thr Pro Trp Ile Asp Asp Asn Pro Ser Thr Glu Thr Ala Gln Ala 
305                 310                 315                 320 


Trp Asn Ala Gly Phe Leu Arg Gly Arg Ala Tyr Gly Ile Asp Leu Leu 
                325                 330                 335     


Arg Thr Glu Gly Glu His Val Glu Gly Ala Thr Gly Glu Thr Arg Glu 
            340                 345                 350         


Glu Ser Glu Asp Thr Glu Ser Asp Gly Asp Asp Glu Asp Leu Pro Cys 
        355                 360                 365             


Ile Val Ser Arg Gly Gly Pro Lys Val Lys Arg Pro Pro Ile Phe Ile 
    370                 375                 380                 


Arg Arg Leu His Arg Leu Leu Leu Met Arg Ala Gly Lys Arg Thr Glu 
385                 390                 395                 400 


Gln Gly Lys Glu Val Leu Glu Lys Ala Arg Gly Ser Thr Tyr Gly Thr 
                405                 410                 415     


Pro Arg Pro Pro Val Pro Lys Pro Arg Pro Glu Val Pro Gln Ser Asp 
            420                 425                 430         


Glu Thr Ala Thr Ser His Gly Ser Ala Gln Val Pro Glu Pro Pro Thr 
        435                 440                 445             


Ile His Leu Ala Ala Gln Gly Met Ala Tyr Pro Leu His Glu Gln His 
    450                 455                 460                 


Gly Met Ala Pro Cys Pro Val Ala Gln Ala Pro Pro Thr Pro Leu Pro 
465                 470                 475                 480 


Pro Val Ser Pro Gly Asp Gln Leu Pro Gly Val Phe Ser Asp Gly Arg 
                485                 490                 495     


Val Ala Cys Ala Pro Val Pro Ala Pro Ala Gly Pro Ile Val Arg Pro 
            500                 505                 510         


Trp Glu Pro Ser Leu Thr Gln Ala Ala Gly Gln Ala Phe Ala Pro Val 
        515                 520                 525             


Arg Pro Gln His Met Pro Val Glu Pro Val Pro Val Pro Thr Val Ala 
    530                 535                 540                 


Leu Glu Arg Pro Val Tyr Pro Lys Pro Val Arg Pro Ala Pro Pro Lys 
545                 550                 555                 560 


Ile Ala Met Gln Gly Pro Gly Glu Thr Ser Gly Ile Arg Arg Ala Arg 
                565                 570                 575     


Glu Arg Trp Arg Pro Ala Pro Trp Thr Pro Asn Pro Pro Arg Ser Pro 
            580                 585                 590         


Ser Gln Met Ser Val Arg Asp Arg Leu Ala Arg Leu Arg Ala Glu Ala 
        595                 600                 605             


Gln Val Lys Gln Ala Ser Val Glu Val Gln Pro Pro Gln Leu Thr Gln 
    610                 615                 620                 


Val Ser Pro Gln Gln Pro Met Glu Gly Pro Leu Val Pro Glu Gln Gln 
625                 630                 635                 640 


Met Phe Pro Gly Ala Pro Phe Ser Gln Val Ala Asp Val Val Arg Ala 
                645                 650                 655     


Pro Gly Val Pro Ala Met Gln Pro Gln Tyr Phe Asp Leu Pro Leu Ile 
            660                 665                 670         


Gln Pro Ile Ser Gln Gly Ala Pro Val Ala Pro Leu Arg Ala Ser Met 
        675                 680                 685             


Gly Pro Val Pro Pro Val Pro Ala Thr Gln Pro Gln Tyr Phe Asp Ile 
    690                 695                 700                 


Pro Leu Thr Glu Pro Ile Asn Gln Gly Ala Ser Ala Ala His Phe Leu 
705                 710                 715                 720 


Pro Gln Gln Pro Met Glu Gly Pro Leu Val Pro Glu Gln Trp Met Phe 
                725                 730                 735     


Pro Gly Ala Ala Leu Ser Gln Ser Val Arg Pro Gly Val Ala Gln Ser 
            740                 745                 750         


Gln Tyr Phe Asp Leu Pro Leu Thr Gln Pro Ile Asn His Gly Ala Pro 
        755                 760                 765             


Ala Ala His Phe Leu His Gln Pro Pro Met Glu Gly Pro Trp Val Pro 
    770                 775                 780                 


Glu Gln Trp Met Phe Gln Gly Ala Pro Pro Ser Gln Gly Thr Asp Val 
785                 790                 795                 800 


Val Gln His Gln Leu Asp Ala Leu Gly Tyr Thr Leu His Gly Leu Asn 
                805                 810                 815     


His Pro Gly Val Pro Val Ser Pro Ala Val Asn Gln Tyr His Leu Ser 
            820                 825                 830         


Gln Ala Ala Phe Gly Leu Pro Ile Asp Glu Asp Glu Ser Gly Glu Gly 
        835                 840                 845             


Ser Asp Thr Ser Glu Pro Cys Glu Ala Leu Asp Leu Ser Ile His Gly 
    850                 855                 860                 


Arg Pro Cys Pro Gln Ala Pro Glu Trp Pro Val Gln Glu Glu Gly Gly 
865                 870                 875                 880 


Gln Asp Ala Thr Glu Val Leu Asp Leu Ser Ile His Gly Arg Pro Arg 
                885                 890                 895     


Pro Arg Thr Pro Glu Trp Pro Val Gln Gly Glu Gly Gly Gln Asn Val 
            900                 905                 910         


Thr Gly Pro Glu Thr Arg Arg Val Val Val Ser Ala Val Val His Met 
        915                 920                 925             


Cys Gln Asp Asp Glu Phe Pro Asp Leu Gln Asp Pro Pro Asp Glu Ala 
    930                 935                 940                 


<210>  10
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Asp Glu Gly Pro Gly Thr Gly Pro Gly Asn Gly Leu Gly Glu 
1               5                   10                  15      


Lys Gly Asp Thr Ser Gly Pro Glu Gly Ser Gly Gly Ser Gly Pro Gln 
            20                  25                  30          


Arg Arg Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly 
        35                  40                  45              


Arg Gly Gly Gly Arg Pro Gly Ala Pro Gly Gly Ser Gly Ser Gly Pro 
    50                  55                  60                  


Arg His Arg Asp Gly Val Arg Arg Pro Gln Lys Arg Pro Ser Cys Ile 
65                  70                  75                  80  


Gly Cys Lys Gly Thr His Gly Gly Thr Gly Ala Gly Ala Gly Ala Gly 
                85                  90                  95      


Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Ala Gly 
            100                 105                 110         


Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly 
        115                 120                 125             


Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala 
    130                 135                 140                 


Gly Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly 
145                 150                 155                 160 


Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly 
                165                 170                 175     


Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly 
            180                 185                 190         


Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly 
        195                 200                 205             


Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala 
    210                 215                 220                 


Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly 
                245                 250                 255     


Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly 
            260                 265                 270         


Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly 
        275                 280                 285             


Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Gly Ala Gly 
    290                 295                 300                 


Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Ala Gly 
305                 310                 315                 320 


Gly Ala Gly Ala Gly Gly Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly 
                325                 330                 335     


Arg Gly Arg Gly Gly Ser Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly 
            340                 345                 350         


Arg Arg Gly Arg Gly Arg Glu Arg Ala Arg Gly Gly Ser Arg Glu Arg 
        355                 360                 365             


Ala Arg Gly Arg Gly Arg Gly Arg Gly Glu Lys Arg Pro Arg Ser Pro 
    370                 375                 380                 


Ser Ser Gln Ser Ser Ser Ser Gly Ser Pro Pro Arg Arg Pro Pro Pro 
385                 390                 395                 400 


Gly Arg Arg Pro Phe Phe His Pro Val Gly Glu Ala Asp Tyr Phe Glu 
                405                 410                 415     


Tyr His Gln Glu Gly Gly Pro Asp Gly Glu Pro Asp Val Pro Pro Gly 
            420                 425                 430         


Ala Ile Glu Gln Gly Pro Ala Asp Asp Pro Gly Glu Gly Pro Ser Thr 
        435                 440                 445             


Gly Pro Arg Gly Gln Gly Asp Gly Gly Arg Arg Lys Lys Gly Gly Trp 
    450                 455                 460                 


Phe Gly Lys His Arg Gly Gln Gly Gly Ser Asn Pro Lys Phe Glu Asn 
465                 470                 475                 480 


Ile Ala Glu Gly Leu Arg Ala Leu Leu Ala Arg Ser His Val Glu Arg 
                485                 490                 495     


Thr Thr Asp Glu Gly Thr Trp Val Ala Gly Val Phe Val Tyr Gly Gly 
            500                 505                 510         


Ser Lys Thr Ser Leu Tyr Asn Leu Arg Arg Gly Thr Ala Leu Ala Ile 
        515                 520                 525             


Pro Gln Cys Arg Leu Thr Pro Leu Ser Arg Leu Pro Phe Gly Met Ala 
    530                 535                 540                 


Pro Gly Pro Gly Pro Gln Pro Gly Pro Leu Arg Glu Ser Ile Val Cys 
545                 550                 555                 560 


Tyr Phe Met Val Phe Leu Gln Thr His Ile Phe Ala Glu Val Leu Lys 
                565                 570                 575     


Asp Ala Ile Lys Asp Leu Val Met Thr Lys Pro Ala Pro Thr Cys Asn 
            580                 585                 590         


Ile Arg Val Thr Val Cys Ser Phe Asp Asp Gly Val Asp Leu Pro Pro 
        595                 600                 605             


Trp Phe Pro Pro Met Val Glu Gly Ala Ala Ala Glu Gly Asp Asp Gly 
    610                 615                 620                 


Asp Asp Gly Asp Glu Gly Gly Asp Gly Asp Glu Gly Glu Glu Gly Gln 
625                 630                 635                 640 


Glu 
    


<210>  11
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Leu Trp Leu Pro Ser Glu Ala Thr Val Tyr Leu Pro Pro Val 
1               5                   10                  15      


Pro Val Ser Lys Val Val Ser Thr Asp Glu Tyr Val Ala Arg Thr Asn 
            20                  25                  30          


Ile Tyr Tyr His Ala Gly Thr Ser Arg Leu Leu Ala Val Gly His Pro 
        35                  40                  45              


Tyr Phe Pro Ile Lys Lys Pro Asn Asn Asn Lys Ile Leu Val Pro Lys 
    50                  55                  60                  


Val Ser Gly Leu Gln Tyr Arg Val Phe Arg Ile His Leu Pro Asp Pro 
65                  70                  75                  80  


Asn Lys Phe Gly Phe Pro Asp Thr Ser Phe Tyr Asn Pro Asp Thr Gln 
                85                  90                  95      


Arg Leu Val Trp Ala Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro 
            100                 105                 110         


Leu Gly Val Gly Ile Ser Gly His Pro Leu Leu Asn Lys Leu Asp Asp 
        115                 120                 125             


Thr Glu Asn Ala Ser Ala Tyr Ala Ala Asn Ala Gly Val Asp Asn Arg 
    130                 135                 140                 


Glu Cys Ile Ser Met Asp Tyr Lys Gln Thr Gln Leu Cys Leu Ile Gly 
145                 150                 155                 160 


Cys Lys Pro Pro Ile Gly Glu His Trp Gly Lys Gly Ser Pro Cys Thr 
                165                 170                 175     


Asn Val Ala Val Asn Pro Gly Asp Cys Pro Pro Leu Glu Leu Ile Asn 
            180                 185                 190         


Thr Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
        195                 200                 205             


Asp Phe Thr Thr Leu Gln Ala Asn Lys Ser Glu Val Pro Leu Asp Ile 
    210                 215                 220                 


Cys Thr Ser Ile Cys Lys Tyr Pro Asp Tyr Ile Lys Met Val Ser Glu 
225                 230                 235                 240 


Pro Tyr Gly Asp Ser Leu Phe Phe Tyr Leu Arg Arg Glu Gln Met Phe 
                245                 250                 255     


Val Arg His Leu Phe Asn Arg Ala Gly Ala Val Gly Glu Asn Val Pro 
            260                 265                 270         


Asp Asp Leu Tyr Ile Lys Gly Ser Gly Ser Thr Ala Asn Leu Ala Ser 
        275                 280                 285             


Ser Asn Tyr Phe Pro Thr Pro Ser Gly Ser Met Val Thr Ser Asp Ala 
    290                 295                 300                 


Gln Ile Phe Asn Lys Pro Tyr Trp Leu Gln Arg Ala Gln Gly His Asn 
305                 310                 315                 320 


Asn Gly Ile Cys Trp Gly Asn Gln Leu Phe Val Thr Val Val Asp Thr 
                325                 330                 335     


Thr Arg Ser Thr Asn Met Ser Leu Cys Ala Ala Ile Ser Thr Ser Glu 
            340                 345                 350         


Thr Thr Tyr Lys Asn Thr Asn Phe Lys Glu Tyr Leu Arg His Gly Glu 
        355                 360                 365             


Glu Tyr Asp Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 


Ala Asp Val Met Thr Tyr Ile His Ser Met Asn Ser Thr Ile Leu Glu 
385                 390                 395                 400 


Asp Trp Asn Phe Gly Leu Gln Pro Pro Pro Gly Gly Thr Leu Glu Asp 
                405                 410                 415     


Thr Tyr Arg Phe Val Thr Ser Gln Ala Ile Ala Cys Gln Lys His Thr 
            420                 425                 430         


Pro Pro Ala Pro Lys Glu Asp Pro Leu Lys Lys Tyr Thr Phe Trp Glu 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Phe Ser Ala Asp Leu Asp Gln Phe Pro Leu 
    450                 455                 460                 


Gly Arg Lys Phe Leu Leu Gln Ala Gly Leu Lys Ala Lys Pro Lys Phe 
465                 470                 475                 480 


Thr Leu Gly Lys Arg Lys Ala Thr Pro Thr Thr Ser Ser Thr Ser Thr 
                485                 490                 495     


Thr Ala Lys Arg Lys Lys Arg Lys Leu 
            500                 505 


<210>  12
<211>  1718
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Gln Asn Thr Thr Glu Pro Val Ala Ala Thr Glu Thr Leu Ala 
1               5                   10                  15      


Glu Val Pro Glu His Val Leu Arg Gly Leu Pro Glu Glu Val Arg Leu 
            20                  25                  30          


Phe Pro Ser Ala Val Asp Lys Thr Arg Ile Gly Val Trp Ala Thr Lys 
        35                  40                  45              


Pro Ile Leu Lys Gly Lys Lys Phe Gly Pro Phe Val Gly Asp Lys Lys 
    50                  55                  60                  


Lys Arg Ser Gln Val Lys Asn Asn Val Tyr Met Trp Glu Val Tyr Tyr 
65                  70                  75                  80  


Pro Asn Leu Gly Trp Met Cys Ile Asp Ala Thr Asp Pro Glu Lys Gly 
                85                  90                  95      


Asn Trp Leu Arg Tyr Val Asn Trp Ala Cys Ser Gly Glu Glu Gln Asn 
            100                 105                 110         


Leu Phe Pro Leu Glu Ile Asn Arg Ala Ile Tyr Tyr Lys Thr Leu Lys 
        115                 120                 125             


Pro Ile Ala Pro Gly Glu Glu Leu Leu Val Trp Tyr Asn Gly Glu Asp 
    130                 135                 140                 


Asn Pro Glu Ile Ala Ala Ala Ile Glu Glu Glu Arg Ala Ser Ala Arg 
145                 150                 155                 160 


Ser Lys Arg Ser Ser Pro Lys Ser Arg Lys Gly Lys Lys Lys Ser Gln 
                165                 170                 175     


Glu Asn Lys Asn Lys Gly Asn Lys Ile Gln Asp Ile Gln Leu Lys Thr 
            180                 185                 190         


Ser Glu Pro Asp Phe Thr Ser Ala Asn Met Arg Asp Ser Ala Glu Gly 
        195                 200                 205             


Pro Lys Glu Asp Glu Glu Lys Pro Ser Ala Ser Ala Leu Glu Gln Pro 
    210                 215                 220                 


Ala Thr Leu Gln Glu Val Ala Ser Gln Glu Val Pro Pro Glu Leu Ala 
225                 230                 235                 240 


Thr Pro Ala Pro Ala Trp Glu Pro Gln Pro Glu Pro Asp Glu Arg Leu 
                245                 250                 255     


Glu Ala Ala Ala Cys Glu Val Asn Asp Leu Gly Glu Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp Glu 
        275                 280                 285             


Leu Glu Asp Glu Gly Glu Glu Glu Ala Ser Met Pro Asn Glu Asn Ser 
    290                 295                 300                 


Val Lys Glu Pro Glu Ile Arg Cys Asp Glu Lys Pro Glu Asp Leu Leu 
305                 310                 315                 320 


Glu Glu Pro Lys Thr Thr Ser Glu Glu Thr Leu Glu Asp Cys Ser Glu 
                325                 330                 335     


Val Thr Pro Ala Met Gln Ile Pro Arg Thr Lys Glu Glu Ala Asn Gly 
            340                 345                 350         


Asp Val Phe Glu Thr Phe Met Phe Pro Cys Gln His Cys Glu Arg Lys 
        355                 360                 365             


Phe Thr Thr Lys Gln Gly Leu Glu Arg His Met His Ile His Ile Ser 
    370                 375                 380                 


Thr Val Asn His Ala Phe Lys Cys Lys Tyr Cys Gly Lys Ala Phe Gly 
385                 390                 395                 400 


Thr Gln Ile Asn Arg Arg Arg His Glu Arg Arg His Glu Ala Gly Leu 
                405                 410                 415     


Lys Arg Lys Pro Ser Gln Thr Leu Gln Pro Ser Glu Asp Leu Ala Asp 
            420                 425                 430         


Gly Lys Ala Ser Gly Glu Asn Val Ala Ser Lys Asp Asp Ser Ser Pro 
        435                 440                 445             


Pro Ser Leu Gly Pro Asp Cys Leu Ile Met Asn Ser Glu Lys Ala Ser 
    450                 455                 460                 


Gln Asp Thr Ile Asn Ser Ser Val Val Glu Glu Asn Gly Glu Val Lys 
465                 470                 475                 480 


Glu Leu His Pro Cys Lys Tyr Cys Lys Lys Val Phe Gly Thr His Thr 
                485                 490                 495     


Asn Met Arg Arg His Gln Arg Arg Val His Glu Arg His Leu Ile Pro 
            500                 505                 510         


Lys Gly Val Arg Arg Lys Gly Gly Leu Glu Glu Pro Gln Pro Pro Ala 
        515                 520                 525             


Glu Gln Ala Gln Ala Thr Gln Asn Val Tyr Val Pro Ser Thr Glu Pro 
    530                 535                 540                 


Glu Glu Glu Gly Glu Ala Asp Asp Val Tyr Ile Met Asp Ile Ser Ser 
545                 550                 555                 560 


Asn Ile Ser Glu Asn Leu Asn Tyr Tyr Ile Asp Gly Lys Ile Gln Thr 
                565                 570                 575     


Asn Asn Asn Thr Ser Asn Cys Asp Val Ile Glu Met Glu Ser Ala Ser 
            580                 585                 590         


Ala Asp Leu Tyr Gly Ile Asn Cys Leu Leu Thr Pro Val Thr Val Glu 
        595                 600                 605             


Ile Thr Gln Asn Ile Lys Thr Thr Gln Val Pro Val Thr Glu Asp Leu 
    610                 615                 620                 


Pro Lys Glu Pro Leu Gly Ser Thr Asn Ser Glu Ala Lys Lys Arg Arg 
625                 630                 635                 640 


Thr Ala Ser Pro Pro Ala Leu Pro Lys Ile Lys Ala Glu Thr Asp Ser 
                645                 650                 655     


Asp Pro Met Val Pro Ser Cys Ser Leu Ser Leu Pro Leu Ser Ile Ser 
            660                 665                 670         


Thr Thr Glu Ala Val Ser Phe His Lys Glu Lys Ser Val Tyr Leu Ser 
        675                 680                 685             


Ser Lys Leu Lys Gln Leu Leu Gln Thr Gln Asp Lys Leu Thr Pro Ala 
    690                 695                 700                 


Gly Ile Ser Ala Thr Glu Ile Ala Lys Leu Gly Pro Val Cys Val Ser 
705                 710                 715                 720 


Ala Pro Ala Ser Met Leu Pro Val Thr Ser Ser Arg Phe Lys Arg Arg 
                725                 730                 735     


Thr Ser Ser Pro Pro Ser Ser Pro Gln His Ser Pro Ala Leu Arg Asp 
            740                 745                 750         


Phe Gly Lys Pro Ser Asp Gly Lys Ala Ala Trp Thr Asp Ala Gly Leu 
        755                 760                 765             


Thr Ser Lys Lys Ser Lys Leu Glu Ser His Ser Asp Ser Pro Ala Trp 
    770                 775                 780                 


Ser Leu Ser Gly Arg Asp Glu Arg Glu Thr Val Ser Pro Pro Cys Phe 
785                 790                 795                 800 


Asp Glu Tyr Lys Met Ser Lys Glu Trp Thr Ala Ser Ser Ala Phe Ser 
                805                 810                 815     


Ser Val Cys Asn Gln Gln Pro Leu Asp Leu Ser Ser Gly Val Lys Gln 
            820                 825                 830         


Lys Ala Glu Gly Thr Gly Lys Thr Pro Val Gln Trp Glu Ser Val Leu 
        835                 840                 845             


Asp Leu Ser Val His Lys Lys His Cys Ser Asp Ser Glu Gly Lys Glu 
    850                 855                 860                 


Phe Lys Glu Ser His Ser Val Gln Pro Thr Cys Ser Ala Val Lys Lys 
865                 870                 875                 880 


Arg Lys Pro Thr Thr Cys Met Leu Gln Lys Val Leu Leu Asn Glu Tyr 
                885                 890                 895     


Asn Gly Ile Asp Leu Pro Val Glu Asn Pro Ala Asp Gly Thr Arg Ser 
            900                 905                 910         


Pro Ser Pro Cys Lys Ser Leu Glu Ala Gln Pro Asp Pro Asp Leu Gly 
        915                 920                 925             


Pro Gly Ser Gly Phe Pro Ala Pro Thr Val Glu Ser Thr Pro Asp Val 
    930                 935                 940                 


Cys Pro Ser Ser Pro Ala Leu Gln Thr Pro Ser Leu Ser Ser Gly Gln 
945                 950                 955                 960 


Leu Pro Pro Leu Leu Ile Pro Thr Asp Pro Ser Ser Pro Pro Pro Cys 
                965                 970                 975     


Pro Pro Val Leu Thr Val Ala Thr Pro Pro Pro Pro Leu Leu Pro Thr 
            980                 985                 990         


Val Pro Leu Pro Ala Pro Ser Ser  Ser Ala Ser Pro His  Pro Cys Pro 
        995                 1000                 1005             


Ser Pro  Leu Ser Asn Ala Thr  Ala Gln Ser Pro Leu  Pro Ile Leu 
    1010                 1015                 1020             


Ser Pro  Thr Val Ser Pro Ser  Pro Ser Pro Ile Pro  Pro Val Glu 
    1025                 1030                 1035             


Pro Leu  Met Ser Ala Ala Ser  Pro Gly Pro Pro Thr  Leu Ser Ser 
    1040                 1045                 1050             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Phe Ser  Ser Ser Ser 
    1055                 1060                 1065             


Ser Ser  Ser Ser Pro Ser Pro  Pro Pro Leu Ser Ala  Ile Ser Ser 
    1070                 1075                 1080             


Val Val  Ser Ser Gly Asp Asn  Leu Glu Ala Ser Leu  Pro Met Ile 
    1085                 1090                 1095             


Ser Phe  Lys Gln Glu Glu Leu  Glu Asn Glu Gly Leu  Lys Pro Arg 
    1100                 1105                 1110             


Glu Glu  Pro Gln Ser Ala Ala  Glu Gln Asp Val Val  Val Gln Glu 
    1115                 1120                 1125             


Thr Phe  Asn Lys Asn Phe Val  Cys Asn Val Cys Glu  Ser Pro Phe 
    1130                 1135                 1140             


Leu Ser  Ile Lys Asp Leu Thr  Lys His Leu Ser Ile  His Ala Glu 
    1145                 1150                 1155             


Glu Trp  Pro Phe Lys Cys Glu  Phe Cys Val Gln Leu  Phe Lys Asp 
    1160                 1165                 1170             


Lys Thr  Asp Leu Ser Glu His  Arg Phe Leu Leu His  Gly Val Gly 
    1175                 1180                 1185             


Asn Ile  Phe Val Cys Ser Val  Cys Lys Lys Glu Phe  Ala Phe Leu 
    1190                 1195                 1200             


Cys Asn  Leu Gln Gln His Gln  Arg Asp Leu His Pro  Asp Lys Val 
    1205                 1210                 1215             


Cys Thr  His His Glu Phe Glu  Ser Gly Thr Leu Arg  Pro Gln Asn 
    1220                 1225                 1230             


Phe Thr  Asp Pro Ser Lys Ala  His Val Glu His Met  Gln Ser Leu 
    1235                 1240                 1245             


Pro Glu  Asp Pro Leu Glu Thr  Ser Lys Glu Glu Glu  Glu Leu Asn 
    1250                 1255                 1260             


Asp Ser  Ser Glu Glu Leu Tyr  Thr Thr Ile Lys Ile  Met Ala Ser 
    1265                 1270                 1275             


Gly Ile  Lys Thr Lys Asp Pro  Asp Val Arg Leu Gly  Leu Asn Gln 
    1280                 1285                 1290             


His Tyr  Pro Ser Phe Lys Pro  Pro Pro Phe Gln Tyr  His His Arg 
    1295                 1300                 1305             


Asn Pro  Met Gly Ile Gly Val  Thr Ala Thr Asn Phe  Thr Thr His 
    1310                 1315                 1320             


Asn Ile  Pro Gln Thr Phe Thr  Thr Ala Ile Arg Cys  Thr Lys Cys 
    1325                 1330                 1335             


Gly Lys  Gly Val Asp Asn Met  Pro Glu Leu His Lys  His Ile Leu 
    1340                 1345                 1350             


Ala Cys  Ala Ser Ala Ser Asp  Lys Lys Arg Tyr Thr  Pro Lys Lys 
    1355                 1360                 1365             


Asn Pro  Val Pro Leu Lys Gln  Thr Val Gln Pro Lys  Asn Gly Val 
    1370                 1375                 1380             


Val Val  Leu Asp Asn Ser Gly  Lys Asn Ala Phe Arg  Arg Met Gly 
    1385                 1390                 1395             


Gln Pro  Lys Arg Leu Asn Phe  Ser Val Glu Leu Ser  Lys Met Ser 
    1400                 1405                 1410             


Ser Asn  Lys Leu Lys Leu Asn  Ala Leu Lys Lys Lys  Asn Gln Leu 
    1415                 1420                 1425             


Val Gln  Lys Ala Ile Leu Gln  Lys Asn Lys Ser Ala  Lys Gln Lys 
    1430                 1435                 1440             


Ala Asp  Leu Lys Asn Ala Cys  Glu Ser Ser Ser His  Ile Cys Pro 
    1445                 1450                 1455             


Tyr Cys  Asn Arg Glu Phe Thr  Tyr Ile Gly Ser Leu  Asn Lys His 
    1460                 1465                 1470             


Ala Ala  Phe Ser Cys Pro Lys  Lys Pro Leu Ser Pro  Pro Lys Lys 
    1475                 1480                 1485             


Lys Val  Ser His Ser Ser Lys  Lys Gly Gly His Ser  Ser Pro Ala 
    1490                 1495                 1500             


Ser Ser  Asp Lys Asn Ser Asn  Ser Asn His Arg Arg  Arg Thr Ala 
    1505                 1510                 1515             


Asp Ala  Glu Ile Lys Met Gln  Ser Met Gln Thr Pro  Leu Gly Lys 
    1520                 1525                 1530             


Thr Arg  Ala Arg Ser Ser Gly  Pro Thr Gln Val Pro  Leu Pro Ser 
    1535                 1540                 1545             


Ser Ser  Phe Arg Ser Lys Gln  Asn Val Lys Phe Ala  Ala Ser Val 
    1550                 1555                 1560             


Lys Ser  Lys Lys Pro Ser Ser  Ser Ser Leu Arg Asn  Ser Ser Pro 
    1565                 1570                 1575             


Ile Arg  Met Ala Lys Ile Thr  His Val Glu Gly Lys  Lys Pro Lys 
    1580                 1585                 1590             


Ala Val  Ala Lys Asn His Ser  Ala Gln Leu Ser Ser  Lys Thr Ser 
    1595                 1600                 1605             


Arg Ser  Leu His Val Arg Val  Gln Lys Ser Lys Ala  Val Leu Gln 
    1610                 1615                 1620             


Ser Lys  Ser Thr Leu Ala Ser  Lys Lys Arg Thr Asp  Arg Phe Asn 
    1625                 1630                 1635             


Ile Lys  Ser Arg Glu Arg Ser  Gly Gly Pro Val Thr  Arg Ser Leu 
    1640                 1645                 1650             


Gln Leu  Ala Ala Ala Ala Asp  Leu Ser Glu Asn Lys  Arg Glu Asp 
    1655                 1660                 1665             


Gly Ser  Ala Lys Gln Glu Leu  Lys Asp Phe Ser Tyr  Ser Leu Arg 
    1670                 1675                 1680             


Leu Ala  Ser Arg Cys Ser Pro  Pro Ala Ala Pro Tyr  Ile Thr Arg 
    1685                 1690                 1695             


Gln Tyr  Arg Lys Val Lys Ala  Pro Ala Ala Ala Gln  Phe Gln Gly 
    1700                 1705                 1710             


Pro Phe  Phe Lys Glu 
    1715             


<210>  13
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Gly Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr 
1               5                   10                  15      


Asn Gln Phe Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val 
            20                  25                  30          


Asp Val Tyr Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro 
        35                  40                  45              


Val Cys Ala Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val 
    50                  55                  60                  


Phe Arg Thr Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val 
65                  70                  75                  80  


Thr Ser Ser Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly 
                85                  90                  95      


Thr Ile Gly Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His 
            100                 105                 110         


Phe Glu Ser Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser 
        115                 120                 125             


Met Ser Pro Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile 
    130                 135                 140                 


Arg Val Thr His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro 
145                 150                 155                 160 


Ser Ile Asp Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val 
                165                 170                 175     


Asp Gly His Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn 
            180                 185                 190         


His Gly Glu Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val 
        195                 200                 205             


Cys Lys Lys Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala 
    210                 215                 220                 


Ile Ala Leu Ser Ala Ala 
225                 230 


<210>  14
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn Gly Pro Ala Asp Gly Glu Val Asp Tyr Lys Lys Lys Tyr Arg 
1               5                   10                  15      


Asn Leu Lys Arg Lys Leu Lys Phe Leu Ile Tyr Glu His Glu Cys Phe 
            20                  25                  30          


Gln Glu Glu Leu Arg Lys Ala Gln Arg Lys Leu Leu Lys Val Ser Arg 
        35                  40                  45              


Asp Lys Ser Phe Leu Leu Asp Arg Leu Leu Gln Tyr Glu Asn Val Asp 
    50                  55                  60                  


Glu Asp Ser Ser Asp Ser Asp Ala Thr Ala Ser Ser Asp Asn Ser Glu 
65                  70                  75                  80  


Thr Glu Gly Thr Pro Lys Leu Ser Asp Thr Pro Ala Pro Lys Arg Lys 
                85                  90                  95      


Arg Ser Pro Pro Leu Gly Gly Ala Pro Ser Pro Ser Ser Leu Ser Leu 
            100                 105                 110         


Pro Pro Ser Thr Gly Phe Pro Leu Gln Ala Ser Gly Val Pro Ser Pro 
        115                 120                 125             


Tyr Leu Ser Ser Leu Ala Ser Ser Arg Tyr Pro Pro Phe Pro Ser Asp 
    130                 135                 140                 


Tyr Leu Ala Leu Gln Leu Pro Glu Pro Ser Pro Leu Arg Pro Lys Arg 
145                 150                 155                 160 


Glu Lys Arg Pro Arg Leu Pro Arg Lys Leu Lys Met Ala Val Gly Pro 
                165                 170                 175     


Pro Asp Cys Pro Val Gly Gly Pro Leu Thr Phe Pro Gly Arg Gly Ser 
            180                 185                 190         


Gly Ala Gly Val Gly Thr Thr Leu Thr Pro Leu Pro Pro Pro Lys Met 
        195                 200                 205             


Pro Pro Pro Thr Ile Leu Ser Thr Val Pro Arg Gln Met Phe Ser Asp 
    210                 215                 220                 


Ala Gly Ser Gly Asp Asp Ala Leu Asp Gly Asp Asp Asp Leu Val Ile 
225                 230                 235                 240 


Asp Ile Pro Glu 
                


<210>  15
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asn Leu Leu Gly Ser Arg Arg Val Phe Ser Lys Lys Cys Arg Leu 
1               5                   10                  15      


Val Lys Phe Ser Met Val Ala Leu Val Ser Ala Thr Met Ala Val Thr 
            20                  25                  30          


Thr Val Thr Leu Glu Asn Thr Ala Leu Ala Arg Gln Thr Gln Val Ser 
        35                  40                  45              


Asn Asp Val Val Leu Asn Asp Gly Ala Ser Lys Tyr Leu Asn Glu Ala 
    50                  55                  60                  


Leu Ala Trp Thr Phe Asn Asp Ser Pro Asn Tyr Tyr Lys Thr Leu Gly 
65                  70                  75                  80  


Thr Ser Gln Ile Thr Pro Ala Leu Phe Pro Lys Ala Gly Asp Ile Leu 
                85                  90                  95      


Tyr Ser Lys Leu Asp Glu Leu Gly Arg Thr Arg Thr Ala Arg Gly Thr 
            100                 105                 110         


Leu Thr Tyr Ala Asn Val Glu Gly Ser Tyr Gly Val Arg Gln Ser Phe 
        115                 120                 125             


Gly Lys Asn Gln Asn Pro Ala Gly Trp Thr Gly Asn Pro Asn His Val 
    130                 135                 140                 


Lys Tyr Lys Ile Glu Trp Leu Asn Gly Leu Ser Tyr Val Gly Asp Phe 
145                 150                 155                 160 


Trp Asn Arg Ser His Leu Ile Ala Asp Ser Leu Gly Gly Asp Ala Leu 
                165                 170                 175     


Arg Val Asn Ala Val Thr Gly Thr Arg Thr Gln Asn Val Gly Gly Arg 
            180                 185                 190         


Asp Gln Lys Gly Gly Met Arg Tyr Thr Glu Gln Arg Ala Gln Glu Trp 
        195                 200                 205             


Leu Glu Ala Asn Arg Asp Gly Tyr Leu Tyr Tyr Glu Val Ala Pro Ile 
    210                 215                 220                 


Tyr Asn Ala Asp Glu Leu Ile Pro Arg Ala Val Val Val Ser Met Gln 
225                 230                 235                 240 


Ser Ser Asp Asn Thr Ile Asn Glu Lys Val Leu Val Tyr Asn Thr Ala 
                245                 250                 255     


Asn Gly Tyr Thr Ile Asn Tyr His Asn Gly Thr Pro Thr Gln Lys 
            260                 265                 270     


