                         SEQUENCE LISTING

<110>  THERANYX
 
<120>  Single-domain antibodies directed against a Cys-loop receptor and
        methods for obtaining them

<130>  B1816PC00

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH4

<400>  1

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Leu Phe Ser Ile Leu 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Arg Asp Thr Thr Gly Tyr Ala Asp Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys 
65                  70                  75                  80  


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Asn Ala Asp Ile Arg Thr Ile Thr Gly Arg Ala Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
        115                 120                 125     


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH5

<400>  2

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Asp Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Asp Tyr Gly Gly Arg Ala Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Arg Thr Val His Val Ile Gln Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Arg 
        115             


<210>  3
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH7

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Ile Val Val His Asn 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Ser Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Gly Gly Gly Met Val Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Ala Asp Ile Pro Arg Asp Trp Gly Val Gln Arg Asp Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg Tyr Pro Tyr Asp Val 
        115                 120                 125             


Pro Asp Tyr Gly Ser Gly Arg Ala 
    130                 135     


<210>  4
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH15

<400>  4

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Tyr Ser Gly Ser Leu Phe Ser Ile Ile 
            20                  25                  30          


Val Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Arg Asp Thr Thr Gly Tyr Ala Asp Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys 
65                  70                  75                  80  


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Asn Ala Asp Ala Arg Thr Ile Thr Gly Arg Ala Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
        115                 120                 125     


<210>  5
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH15s

<400>  5

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Tyr Ser Gly Ser Leu Phe Ser Ile Leu 
            20                  25                  30          


Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Arg Asp Ala Ala Gly Tyr Ala Asp Ser Thr Asn Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys 
65                  70                  75                  80  


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Asn Ala Asp Ala Arg Thr Ile Thr Gly Arg Ala Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
        115                 120                 125     


<210>  6
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH16

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Val Arg Gly Ile Thr Ala Tyr Ser Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Gly Ser Leu Glu Val Leu Arg Thr Glu Arg Tyr Ile Arg 
            100                 105                 110         


Trp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
        115                 120                 125     


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  7

Ala Ser Gly Ser Leu Phe Ser Ile 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  8

Thr Arg Asp Thr Thr Gly Tyr Ala Asp 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  9

Arg Thr Ile Thr Gly Arg Ala Asp Tyr 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  10

Ala Ser Gly Phe Ser Phe Ser Asp 
1               5               


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  11

Ala Asp Tyr Gly Gly Arg 
1               5       


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  12

Gly Gly Arg Thr Val His Val Ile 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  13

Ala Ser Arg Thr Ile Val Val His 
1               5               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  14

Thr Gly Gly Gly 
1               


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  15

Pro Arg Asp Trp Gly Val Gln Arg Asp Val Tyr 
1               5                   10      


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  16

Tyr Ser Gly Ser Leu Phe Ser Ile 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  17

Thr Arg Asp Thr Thr Gly Tyr Ala Asp 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  18

Arg Thr Ile Thr Gly Arg Ala Asp Tyr 
1               5                   


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  19

Tyr Ser Gly Ser Leu Phe Ser Ile 
1               5               


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  20

Thr Arg Asp Ala Ala Gly Tyr Ala Asp 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  21

Arg Thr Ile Thr Gly Arg Ala Asp Tyr 
1               5                   


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  22

Ala Ser Gly Arg Ala Phe Ser Ser 
1               5               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  23

Ser Val Arg Gly Ile 
1               5   


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  24

Ser Leu Glu Val Leu Arg Thr Glu Arg Tyr Ile Arg Trp 
1               5                   10              


<210>  25
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  25

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala 
            20              


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  26

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val 
            20              


<210>  27
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala 
            20              


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  28

Leu Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
1               5                   10                  15      


Val Ala Gly Ile 
            20  


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  29

Ser Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
1               5                   10                  15      


Val Ser 
        


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  30

Asn Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Ser Arg Arg Glu Leu 
1               5                   10                  15      


Val Ala Thr Ile 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  31

Ile Val Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu 
1               5                   10                  15      


Val Ala Gly Ile 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  32

Leu Arg Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu 
1               5                   10                  15      


Val Ala Gly Ile 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  33

Tyr Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
1               5                   10                  15      


Val Ala Ala Ile 
            20  


<210>  34
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  34

Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   10                  15      


Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp Ile 
        35                  40                  


<210>  35
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  35

Ala Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   10                  15      


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
        35                  40          


<210>  36
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  36

Met Val Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys 
1               5                   10                  15      


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala Asp Ile 
        35                  40                  


<210>  37
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  37

Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   10                  15      


Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp Ala 
        35                  40                  


<210>  38
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  38

Thr Ala Tyr Ser Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   10                  15      


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Gly Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Gly 
        35                  40                  


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  39

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  40

Gln Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
1               5                   10              


<210>  41
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  41

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg Tyr Pro Tyr 
1               5                   10                  15      


Asp Val Pro Asp Tyr Gly Ser Gly Arg Ala 
            20                  25      


<210>  42
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHHAB-5

<400>  42

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Tyr Ala Phe Ser 
            20                  25                  30          


Ser Arg Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ala Ala Ile Tyr Thr Gly Thr Ser Ser Thr Ser Tyr Ile Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Met Lys Tyr Gly Trp Gly Gly Ser Trp Ser Arg Ser Asp 
            100                 105                 110         


Glu Tyr Arg Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Arg 
    


<210>  43
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHHAB-13

<400>  43

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Gly Arg Asn Asn Tyr 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Met Glu Arg Glu Gly Val Ala 
        35                  40                  45              


Ala Ile His Thr Gly Gly Val Trp Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Gly Ile Tyr Ala Thr Gly Arg Ile Leu Asp Pro Arg Arg Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
        115                 120                 125         


<210>  44
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHHAB-9

<400>  44

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Asn 
            20                  25                  30          


Ser Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ala Ala Ile Ser Ser Gly Gly Ile Ser Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Val Asn Thr 
65                  70                  75                  80  


Met Ser Leu Leu Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Cys Arg Pro Gly Arg Ser Tyr Asn Ser Pro Leu Ser 
            100                 105                 110         


Ala Asn Val Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Arg 
    130     


<210>  45
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHHAB-10

<400>  45

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ser Glu 
            20                  25                  30          


Thr Tyr Ser Met Gly Trp His Arg Gln Ala Pro Gly Lys Glu His Glu 
        35                  40                  45              


Leu Val Ser Arg Ile Phe Arg Asp Gly Thr Ala Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Ile 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ser Met Tyr Tyr 
                85                  90                  95      


Cys His Thr Ser Leu Gln Lys Gly Arg Phe Gly Leu Glu Glu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
        115                 120                 


<210>  46
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHHAB-18

<400>  46

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Asp Thr Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Gly Val Ala Ile Ile Asp Arg Tyr Gly Gly Trp Thr Val Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Phe Ala Lys Lys Thr 
65                  70                  75                  80  


Val Tyr Leu Leu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Gly Ser Gly Arg Arg Arg Val Thr Thr Pro Leu His 
            100                 105                 110         


Pro Asp Asn Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Gly Arg 
    130     


<210>  47
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHHAB-21

<400>  47

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Tyr Arg Pro 
            20                  25                  30          


Asn Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
        35                  40                  45              


Val Ala Tyr Thr Ser Pro Tyr Gly Gly Arg Leu Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ile Ser Gln Asp Ile Ala Lys Ser 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Val Ser Pro Gln Leu Cys Gly Arg Ile Gly Pro Ala 
            100                 105                 110         


Thr Glu Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Arg 
    130 


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  48

Gly Ser Gly Tyr Ala Phe Ser Ser 
1               5               


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  49

Tyr Thr Gly Thr Ser 
1               5   


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  50

Lys Tyr Gly Trp Gly Gly Ser Trp Ser Arg Ser Asp Glu Tyr Arg Tyr 
1               5                   10                  15      


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  51

Tyr Thr Gly Arg Asn 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  52

His Thr Gly Gly Val 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  53

Asp Gly Ile Tyr Ala Thr Gly Arg Ile Leu Asp Pro Arg Arg Tyr Asn 
1               5                   10                  15      


Tyr 
    


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  54

Ala Ser Gly Tyr Ser Phe Asn Ser 
1               5               


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  55

Ile Ser Ser Gly Gly Ile 
1               5       


<210>  56
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  56

Cys Arg Pro Gly Arg Ser Tyr Asn Ser Pro Leu Ser Ala Asn Val Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  57

Ala Ser Gly Tyr Thr Ser Glu Thr 
1               5               


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  58

Arg Ile Phe Arg Asp Gly 
1               5       


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  59

Thr Ser Leu Gln Lys Gly Arg Phe Gly Leu Glu Glu Tyr 
1               5                   10              


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  60

Ala Ser Glu Asp Thr Gly Ser Thr 
1               5               


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  61

Ile Asp Arg Tyr Gly Gly 
1               5       


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  62

Gly Ser Gly Arg Arg Arg Val Thr Thr Pro Leu His Pro Asp Asn Tyr 
1               5                   10                  15      


Ala Tyr 
        


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  63

Ala Ser Gly Tyr Tyr Arg Pro 
1               5           


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  64

Thr Ser Pro Tyr Gly Gly 
1               5       


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  65

Ser Pro Gln Leu Cys Gly Arg Ile Gly Pro Ala Thr Glu Phe Asp Leu 
1               5                   10                  15      


<210>  66
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  66

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            20                  25  


<210>  67
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  67

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            20                  25  


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  68

Arg Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
1               5                   10                  15      


Val Ala Ala Ile 
            20  


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  69

Asn Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Met Glu Arg Glu Gly 
1               5                   10                  15      


Val Ala Ala Ile 
            20  


<210>  70
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  70

Tyr Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
1               5                   10                  15      


Val Ala Ala 
            


<210>  71
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  71

Tyr Ser Met Gly Trp His Arg Gln Ala Pro Gly Lys Glu His Glu Leu 
1               5                   10                  15      


Val Ser 
        


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  72

Tyr Tyr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Gly 
1               5                   10                  15      


Val Ala Ile 
            


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  73

Asn Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
1               5                   10                  15      


Val Ala Tyr 
            


<210>  74
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  74

Ser Thr Ser Tyr Ile Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu 
1               5                   10                  15      


Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Met 
        35                  40          


<210>  75
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  75

Trp Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln 
1               5                   10                  15      


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
        35                  40          


<210>  76
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  76

Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   10                  15      


Asp Asn Gly Val Asn Thr Met Ser Leu Leu Met Asn Asn Leu Lys Ser 
            20                  25                  30          


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
        35                  40          


<210>  77
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  77

Thr Ala Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln 
1               5                   10                  15      


Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Asp Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ser Met Tyr Tyr Cys His 
        35                  40      


<210>  78
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  78

Trp Thr Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   10                  15      


Asp Phe Ala Lys Lys Thr Val Tyr Leu Leu Met Asn Ser Leu Lys Pro 
            20                  25                  30          


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
        35                  40          


<210>  79
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  79

Arg Leu Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ile 
1               5                   10                  15      


Ser Gln Asp Ile Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu 
            20                  25                  30          


Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Val 
        35                  40                  


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  80

Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
1               5                   10              


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  81

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
1               5                   10              


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR

<400>  82

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Arg 
1               5                   10              


