                               SEQUENCE LISTING

<110> BERG LLC
 
<120> METHODS OF TREATING A METABOLIC SYNDROME BY MODULATING HEAT SHOCK
      PROTEIN (HSP) 90-BETA

<130> 119992-14720

<140>
<141>

<150> 62/108,530
<151> 2015-01-27   

<150> 62/096,649
<151> 2014-12-24

<150> 62/009,116
<151> 2014-06-06

<160> 107    

<170> PatentIn version 3.5

<210> 1
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 1
aggccgacaa gaaugauaag gcagt                                          25


<210> 2
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
acugccuuau cauucuuguc ggccuca                                           27


<210> 3
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
caacgaugau gaacaguaug cuugg                                             25


<210> 4
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ccaagcauac uguucaucau cguugug                                           27


<210> 5
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
cguugcucac uauuacguau aaucc                                             25


<210> 6
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ggauuauacg uaauagugag caacgua                                           27


<210> 7
<211> 2565
<212> DNA
<213> Homo sapiens

<400> 7
atgcccccgt gttcgggcgg ggacggctcc acccctcctg ggccctccct tcgggacagg       60

gactgtcccg cccagagtgc tgaatacccg cgcgaccgtc tggatccccg cccaggaagc      120

ccctctgaag cctcctcgcc gccgtttctg agaagcaggg cacctgttaa ctggtaccaa      180

gaaaaggccc aagtgtttct ctggcatctg ttggtgtctg gatccaccac tctactctgt      240

ctctggaaac agcccttcca cgtctctgca ttccctgtca ctgcgtcact ggccttcaga      300

cagagccaag gtgcagggca acacctctac aaggatctgc agccatttat attgcttagg      360

ctactgatgc ctgaggaaac ccagacccaa gaccaaccga tggaggagga ggaggttgag      420

acgttcgcct ttcaggcaga aattgcccag ttgatgtcat tgatcatcaa tactttctac      480

tcgaacaaag agatctttct gagagagctc atttcaaatt catcagatgc attggacaaa      540

atccggtatg aaagcttgac agatcccagt aaattagact ctgggaaaga gctgcatatt      600

aaccttatac cgaacaaaca agatcgaact ctcactattg tggatactgg aattggaatg      660

accaaggctg acttgatcaa taaccttggt actatcgcca agtctgggac caaagcgttc      720

atggaagctt tgcaggctgg tgcagatatc tctatgattg gccagttcgg tgttggtttt      780

tattctgctt atttggttgc tgagaaagta actgtgatca ccaaacataa cgatgatgag      840

cagtacgctt gggagtcctc agcaggggga tcattcacag tgaggacaga cacaggtgaa      900

cctatgggtc gtggaacaaa agttatccta cacctgaaag aagaccaaac tgagtacttg      960

gaggaacgaa gaataaagga gattgtgaag aaacattctc agtttattgg atatcccatt     1020

actctttttg tggagaagga acgtgataaa gaagtaagcg atgatgaggc tgaagaaaag     1080

gaagacaaag aagaagaaaa agaaaaagaa gagaaagagt cggaagacaa acctgaaatt     1140

gaagatgttg gttctgatga ggaagaagaa aagaaggatg gtgacaagaa gaagaagaag     1200

aagattaagg aaaagtacat cgatcaagaa gagctcaaca aaacaaagcc catctggacc     1260

agaaatcccg acgatattac taatgaggag tacggagaat tctataagag cttgaccaat     1320

gactgggaag atcacttggc agtgaagcat ttttcagttg aaggacagtt ggaattcaga     1380

gcccttctat ttgtcccacg acgtgctcct tttgatctgt ttgaaaacag aaagaaaaag     1440

aacaatatca aattgtatgt acgcagagtt ttcatcatgg ataactgtga ggagctaatc     1500

cctgaatatc tgaacttcat tagaggggtg gtagactcgg aggatctccc tctaaacata     1560

tcccgtgaga tgttgcaaca aagcaaaatt ttgaaagtta tcaggaagaa tttggtcaaa     1620

aaatgcttag aactctttac tgaactggcg gaagataaag agaactacaa gaaattctat     1680

gagcagttct ctaaaaacat aaagcttgga atacacgaag actctcaaaa tcggaagaag     1740

ctttcagagc tgttaaggta ctacacatct gcctctggtg atgagatggt ttctctcaag     1800

gactactgca ccagaatgaa ggagaaccag aaacatatct attatatcac aggtgagacc     1860

aaggaccagg tagctaactc agcctttgtg gaacgtcttc ggaaacatgg cttagaagtg     1920

atctatatga ttgagcccat tgatgagtac tgtgtccaac agctgaagga atttgagggg     1980

aagactttag tgtcagtcac caaagaaggc ctggaacttc cagaggatga agaagagaaa     2040

aagaagcagg aagagaaaaa aacaaagttt gagaacctct gcaaaatcat gaaagacata     2100

ttggagaaaa aagttgaaaa ggtggttgtg tcaaaccgat tggtgacatc tccatgctgt     2160

attgtcacaa gcacatatgg ctggacagca aacatggaga gaatcatgaa agctcaagcc     2220

ctaagagaca actcaacaat gggttacatg gcagcaaaga aacacctgga gataaaccct     2280

gaccattcca ttattgagac cttaaggcaa aaggcagagg ctgataagaa cgacaagtct     2340

gtgaaggatc tggtcatctt gctttatgaa actgcgctcc tgtcttctgg cttcagtctg     2400

gaagatcccc agacacatgc taacaggatc tacaggatga tcaaacttgg tctgggtatt     2460

gatgaagatg accctactgc tgatgatacc agtgctgctg taactgaaga aatgccaccc     2520

cttgaaggag atgacgacac atcacgcatg gaagaagtag actaa                     2565


<210> 8
<211> 854
<212> PRT
<213> Homo sapiens

<400> 8
Met Pro Pro Cys Ser Gly Gly Asp Gly Ser Thr Pro Pro Gly Pro Ser 
1               5                   10                  15      


Leu Arg Asp Arg Asp Cys Pro Ala Gln Ser Ala Glu Tyr Pro Arg Asp 
            20                  25                  30          


Arg Leu Asp Pro Arg Pro Gly Ser Pro Ser Glu Ala Ser Ser Pro Pro 
        35                  40                  45              


Phe Leu Arg Ser Arg Ala Pro Val Asn Trp Tyr Gln Glu Lys Ala Gln 
    50                  55                  60                  


Val Phe Leu Trp His Leu Leu Val Ser Gly Ser Thr Thr Leu Leu Cys 
65                  70                  75                  80  


Leu Trp Lys Gln Pro Phe His Val Ser Ala Phe Pro Val Thr Ala Ser 
                85                  90                  95      


Leu Ala Phe Arg Gln Ser Gln Gly Ala Gly Gln His Leu Tyr Lys Asp 
            100                 105                 110         


Leu Gln Pro Phe Ile Leu Leu Arg Leu Leu Met Pro Glu Glu Thr Gln 
        115                 120                 125             


Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val Glu Thr Phe Ala Phe 
    130                 135                 140                 


Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr 
145                 150                 155                 160 


Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ser Ser Asp 
                165                 170                 175     


Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu 
            180                 185                 190         


Asp Ser Gly Lys Glu Leu His Ile Asn Leu Ile Pro Asn Lys Gln Asp 
        195                 200                 205             


Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly Met Thr Lys Ala Asp 
    210                 215                 220                 


Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe 
225                 230                 235                 240 


Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln Phe 
                245                 250                 255     


Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Thr Val 
            260                 265                 270         


Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala 
        275                 280                 285             


Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly Glu Pro Met Gly Arg 
    290                 295                 300                 


Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr Leu 
305                 310                 315                 320 


Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys His Ser Gln Phe Ile 
                325                 330                 335     


Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu Arg Asp Lys Glu Val 
            340                 345                 350         


Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu 
        355                 360                 365             


Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly 
    370                 375                 380                 


Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys 
385                 390                 395                 400 


Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys 
                405                 410                 415     


Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly 
            420                 425                 430         


Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val 
        435                 440                 445             


Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe 
    450                 455                 460                 


Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Arg Lys Lys Lys 
465                 470                 475                 480 


Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Asn Cys 
                485                 490                 495     


Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp 
            500                 505                 510         


Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser 
        515                 520                 525             


Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys Lys Cys Leu Glu 
    530                 535                 540                 


Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr 
545                 550                 555                 560 


Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile His Glu Asp Ser Gln 
                565                 570                 575     


Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr Thr Ser Ala Ser 
            580                 585                 590         


Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr Arg Met Lys Glu 
        595                 600                 605             


Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr Lys Asp Gln Val 
    610                 615                 620                 


Ala Asn Ser Ala Phe Val Glu Arg Leu Arg Lys His Gly Leu Glu Val 
625                 630                 635                 640 


Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys 
                645                 650                 655     


Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr Lys Glu Gly Leu Glu 
            660                 665                 670         


Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln Glu Glu Lys Lys Thr 
        675                 680                 685             


Lys Phe Glu Asn Leu Cys Lys Ile Met Lys Asp Ile Leu Glu Lys Lys 
    690                 695                 700                 


Val Glu Lys Val Val Val Ser Asn Arg Leu Val Thr Ser Pro Cys Cys 
705                 710                 715                 720 


Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met 
                725                 730                 735     


Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Ala Ala 
            740                 745                 750         


Lys Lys His Leu Glu Ile Asn Pro Asp His Ser Ile Ile Glu Thr Leu 
        755                 760                 765             


Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp Lys Ser Val Lys Asp Leu 
    770                 775                 780                 


Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu 
785                 790                 795                 800 


Glu Asp Pro Gln Thr His Ala Asn Arg Ile Tyr Arg Met Ile Lys Leu 
                805                 810                 815     


Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala Asp Asp Thr Ser Ala 
            820                 825                 830         


Ala Val Thr Glu Glu Met Pro Pro Leu Glu Gly Asp Asp Asp Thr Ser 
        835                 840                 845             


Arg Met Glu Glu Val Asp 
    850                 


<210> 9
<211> 2567
<212> DNA
<213> Homo sapiens

<400> 9
ctccggcgca gtgttgggac tgtctgggta tcggaaagca agcctacgtt gctcactatt       60

acgtataatc cttttctttt caagatgcct gaggaagtgc accatggaga ggaggaggtg      120

gagacttttg cctttcaggc agaaattgcc caactcatgt ccctcatcat caataccttc      180

tattccaaca aggagatttt ccttcgggag ttgatctcta atgcttctga tgccttggac      240

aagattcgct atgagagcct gacagaccct tcgaagttgg acagtggtaa agagctgaaa      300

attgacatca tccccaaccc tcaggaacgt accctgactt tggtagacac aggcattggc      360

atgaccaaag ctgatctcat aaataatttg ggaaccattg ccaagtctgg tactaaagca      420

ttcatggagg ctcttcaggc tggtgcagac atctccatga ttgggcagtt tggtgttggc      480

ttttattctg cctacttggt ggcagagaaa gtggttgtga tcacaaagca caacgatgat      540

gaacagtatg cttgggagtc ttctgctgga ggttccttca ctgtgcgtgc tgaccatggt      600

gagcccattg gcaggggtac caaagtgatc ctccatctta aagaagatca gacagagtac      660

ctagaagaga ggcgggtcaa agaagtagtg aagaagcatt ctcagttcat aggctatccc      720

atcacccttt atttggagaa ggaacgagag aaggaaatta gtgatgatga ggcagaggaa      780

gagaaaggtg agaaagaaga ggaagataaa gatgatgaag aaaaacccaa gatcgaagat      840

gtgggttcag atgaggagga tgacagcggt aaggataaga agaagaaaac taagaagatc      900

aaagagaaat acattgatca ggaagaacta aacaagacca agcctatttg gaccagaaac      960

cctgatgaca tcacccaaga ggagtatgga gaattctaca agagcctcac taatgactgg     1020

gaagaccact tggcagtcaa gcacttttct gtagaaggtc agttggaatt cagggcattg     1080

ctatttattc ctcgtcgggc tccctttgac ctttttgaga acaagaagaa aaagaacaac     1140

atcaaactct atgtccgccg tgtgttcatc atggacagct gtgatgagtt gataccagag     1200

tatctcaatt ttatccgtgg tgtggttgac tctgaggatc tgcccctgaa catctcccga     1260

gaaatgctcc agcagagcaa aatcttgaaa gtcattcgca aaaacattgt taagaagtgc     1320

cttgagctct tctctgagct ggcagaagac aaggagaatt acaagaaatt ctatgaggca     1380

ttctctaaaa atctcaagct tggaatccac gaagactcca ctaaccgccg ccgcctgtct     1440

gagctgctgc gctatcatac ctcccagtct ggagatgaga tgacatctct gtcagagtat     1500

gtttctcgca tgaaggagac acagaagtcc atctattaca tcactggtga gagcaaagag     1560

caggtggcca actcagcttt tgtggagcga gtgcggaaac ggggcttcga ggtggtatat     1620

atgaccgagc ccattgacga gtactgtgtg cagcagctca aggaatttga tgggaagagc     1680

ctggtctcag ttaccaagga gggtctggag ctgcctgagg atgaggagga gaagaagaag     1740

atggaagaga gcaaggcaaa gtttgagaac ctctgcaagc tcatgaaaga aatcttagat     1800

aagaaggttg agaaggtgac aatctccaat agacttgtgt cttcaccttg ctgcattgtg     1860

accagcacct acggctggac agccaatatg gagcggatca tgaaagccca ggcacttcgg     1920

gacaactcca ccatgggcta tatgatggcc aaaaagcacc tggagatcaa ccctgaccac     1980

cccattgtgg agacgctgcg gcagaaggct gaggccgaca agaatgataa ggcagttaag     2040

gacctggtgg tgctgctgtt tgaaaccgcc ctgctatctt ctggcttttc ccttgaggat     2100

ccccagaccc actccaaccg catctatcgc atgatcaagc taggtctagg tattgatgaa     2160

gatgaagtgg cagcagagga acccaatgct gcagttcctg atgagatccc ccctctcgag     2220

ggcgatgagg atgcgtctcg catggaagaa gtcgattagg ttaggagttc atagttggaa     2280

aacttgtgcc cttgtatagt gtccccatgg gctcccactg cagcctcgag tgcccctgtc     2340

ccacctggct ccccctgctg gtgtctagtg tttttttccc tctcctgtcc ttgtgttgaa     2400

ggcagtaaac taagggtgtc aagccccatt ccctctctac tcttgacagc aggattggat     2460

gttgtgtatt gtggtttatt ttattttctt cattttgttc tgaaattaaa gtatgcaaaa     2520

taaagaatat gccgttttaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2567


<210> 10
<211> 724
<212> PRT
<213> Homo sapiens

<400> 10
Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                

<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 11
auacgcgtat tatacgcgau uaac                                              24


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 12
ucuccutctc ccgttcctuc ucca                                              24


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 13
aucuccttct cccgttccuu cucc                                              24


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 14
acuuccttga ccctcctcuc cucc                                              24


<210> 15
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 15
cuuccutgac cctcctctcc ucca                                              24


<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 16
ccacuucctt gaccctccuc uccu                                              24


<210> 17
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 17
uccucctctt tctcacctuu cucu                                              24


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 18
accacutcct tgaccctccu cucc                                              24


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 19
cuccuuctcc cgttccttcu ccaa                                              24


<210> 20
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 20
cacuuccttg accctcctcu ccuc                                              24


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(20)
<223> Phosphorothioate linkage

<400> 21
ucuccacctc ctcctcucca                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(20)
<223> Phosphorothioate linkage

<400> 22
gucuccacct cctccucucc                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(20)
<223> Phosphorothioate linkage

<400> 23
cuccacctcc tcctcuccau                                                   20


<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 24
cucuucctct gcctcatcau cacu                                              24


<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 25
ucucuucctc tgcctcatca ucac                                              24


<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 26
uucucutcct ctgcctcauc auca                                              24


<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 27
uuucucttcc tctgcctcau cauc                                              24


<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 28
cuuucucttc ctctgcctca ucau                                              24


<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 29
augccctgaa ttccaactga ccuu                                              24


<210> 30
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 30
aaugccctga attccaacug accu                                              24


<210> 31
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 31
caaugccctg aattccaacu gacc                                              24


<210> 32
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 32
ugcccugaat tccaactgac cuuc                                              24


<210> 33
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 33
gcaaugccct gaattccaac ugac                                              24


<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 34
acugagacca ggctcttccc auca                                              24


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 35
uuuccutctc tcgttcctuc ucca                                              24


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 36
ucuccutctc tcgttcctuc ucca                                              24


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 37
uuuccutctc ccgttcctuc ucca                                              24


<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 38
auuuccttct ctcgttccuu cucc                                              24


<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 39
aucuccttct ctcgttccuu cucc                                              24


<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 40
auuuccttct cccgttccuu cucc                                              24


<210> 41
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 41
uccucutctt tctcacctuu cucu                                              24


<210> 42
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 42
uuccuuctct cgttccttcu ccaa                                              24


<210> 43
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 43
cuccuuctct cgttccttcu ccaa                                              24


<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (19)..(24)
<223> 2'-O-methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(24)
<223> Phosphorothioate linkage

<400> 44
uuccuuctcc cgttccttcu ccaa                                              24


<210> 45
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
tccttctccc gttccttctc ca                                                22


<210> 46
<211> 22
<212> DNA
<213> Homo sapiens

<400> 46
tccttctctc gttccttctc ca                                                22


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
tccttctccc gttccttctc c                                                 21


<210> 48
<211> 21
<212> DNA
<213> Homo sapiens

<400> 48
tccttctctc gttccttctc c                                                 21


<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
tcctcctctt tctcaccttt ctct                                              24


<210> 50
<211> 24
<212> DNA
<213> Homo sapiens

<400> 50
tcctcttctt tctcaccttt ctct                                              24


<210> 51
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
tccttctccc gttccttctc caa                                               23


<210> 52
<211> 23
<212> DNA
<213> Homo sapiens

<400> 52
tccttctctc gttccttctc caa                                               23


<210> 53
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cell penetrating peptide

<400> 53
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 54
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cell penetrating peptide

<400> 54
Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210> 55
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cell penetrating peptide

<400> 55
Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210> 56
<211> 8
<212> PRT
<213> Artificial sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cell penetrating peptide

<400> 56
Tyr Asp Glu Glu Gly Gly Gly Glu 
1               5               

<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      targeting peptide

<400> 57
Ala Ser Ser Leu Asn Ile Ala 
1               5           


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      targeting peptide

<400> 58
Trp Asp Ala Asn Gly Lys Thr 
1               5           


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      targeting peptide

<400> 59
Gly Glu Thr Arg Ala Pro Leu 
1               5           


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      targeting peptide

<400> 60
Cys Gly His His Pro Val Tyr Ala Cys 
1               5                   


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      targeting peptide

<400> 61
His Ala Ile Tyr Pro Arg His 
1               5           


<210> 62
<211> 48
<212> DNA
<213> Homo sapiens

<400> 62
ttcaagatgc ctgaggaagt gcaccatgga gaggaggagg tggagact                    48


<210> 63
<211> 48
<212> DNA
<213> Macaca nemestrina

<400> 63
ttcaagatgc ctgaggaagt gcaccatgga gaggaggagg tggagact                    48


<210> 64
<211> 48
<212> DNA
<213> Mus musculus

<400> 64
gtcaagatgc ctgaggaagt gcaccatgga gaggaggagg tggagacc                    48


<210> 65
<211> 48
<212> DNA
<213> Homo sapiens

<400> 65
tagtgatgat gaggcagagg aagagaaagg tgagaaagaa gaggaaga                    48


<210> 66
<211> 48
<212> DNA
<213> Macaca nemestrina

<400> 66
tagtgatgat gaggcagagg aagagaaagg tgagaaagaa gaggaaga                    48


<210> 67
<211> 48
<212> DNA
<213> Mus musculus

<400> 67
cagtgatgat gaggcagagg aagagaaagg tgagaaagag gaggaaga                    48


<210> 68
<211> 50
<212> DNA
<213> Homo sapiens

<400> 68
ttctgtagaa ggtcagttgg aattcagggc attgctattt attcctcgtc                  50


<210> 69
<211> 50
<212> DNA
<213> Macaca nemestrina

<400> 69
ttctgtagaa ggtcagttgg aattcagggc attgctattc attcctcgtc                  50


<210> 70
<211> 50
<212> DNA
<213> Mus musculus

<400> 70
ctctgtagaa ggtcagttgg aattcagggc attgctcttc attccccggc                  50


<210> 71
<211> 46
<212> DNA
<213> Homo sapiens

<400> 71
ggaatttgat gggaagagcc tggtctcagt taccaaggag ggtctg                      46


<210> 72
<211> 46
<212> DNA
<213> Mus musculus

<400> 72
ggagtttgat gggaagagcc tggtctcagt taccaaggag ggtctg                      46


<210> 73
<211> 46
<212> DNA
<213> Mus musculus

<400> 73
ggagtttgat gggaagagcc tggtctcagt gactaaggag ggcctg                      46


<210> 74
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 74
auacgcgtat tatacgcgau uaac                                              24


<210> 75
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 75
ucuccutctc ccgttcctuc ucca                                              24


<210> 76
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 76
aucuccttct cccgttccuu cucc                                              24


<210> 77
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 77
acuuccttga ccctcctcuc cucc                                              24


<210> 78
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 78
cuuccutgac cctcctctcc ucca                                              24


<210> 79
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 79
ccacuucctt gaccctccuc uccu                                              24


<210> 80
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 80
uccucctctt tctcacctuu cucu                                              24


<210> 81
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 81
accacutcct tgaccctccu cucc                                              24


<210> 82
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 82
cuccuuctcc cgttccttcu ccaa                                              24


<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 83
cacuuccttg accctcctcu ccuc                                              24


<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 84
ucuccacctc ctcctcucca                                                   20


<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 85
gucuccacct cctccucucc                                                   20


<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 86
cuccacctcc tcctcuccau                                                   20


<210> 87
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
cucuucctct gcctcatcau cacu                                              24


<210> 88
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 88
ucucuucctc tgcctcatca ucac                                              24


<210> 89
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 89
uucucutcct ctgcctcauc auca                                              24


<210> 90
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 90
uuucucttcc tctgcctcau cauc                                              24


<210> 91
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 91
cuuucucttc ctctgcctca ucau                                              24


<210> 92
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 92
augccctgaa ttccaactga ccuu                                              24


<210> 93
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 93
aaugccctga attccaacug accu                                              24


<210> 94
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 94
caaugccctg aattccaacu gacc                                              24


<210> 95
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 95
ugcccugaat tccaactgac cuuc                                              24


<210> 96
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 96
gcaaugccct gaattccaac ugac                                              24


<210> 97
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 97
acugagacca ggctcttccc auca                                              24


<210> 98
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 98
uuuccutctc tcgttcctuc ucca                                              24


<210> 99
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 99
ucuccutctc tcgttcctuc ucca                                              24


<210> 100
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 100
uuuccutctc ccgttcctuc ucca                                              24


<210> 101
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 101
auuuccttct ctcgttccuu cucc                                              24


<210> 102
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 102
aucuccttct ctcgttccuu cucc                                              24


<210> 103
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 103
auuuccttct cccgttccuu cucc                                              24


<210> 104
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 104
uccucutctt tctcacctuu cucu                                              24


<210> 105
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 105
uuccuuctct cgttccttcu ccaa                                              24


<210> 106
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 106
cuccuuctct cgttccttcu ccaa                                              24


<210> 107
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 107
uuccuuctcc cgttccttcu ccaa                                              24

