                         SEQUENCE LISTING

<110>  Solstice Biologics Ltd.
 
<120>  POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND 
       NON-BIOREVERSIBLE GROUPS

<130>  50925-010WO2

<140>  PCT/US15/034749
<141>  2015-06-08

<150>  US 62/009,123
<151>  2014-06-06

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Val Pro Met Leu Lys Pro Met Leu Lys Glu 
1               5                   10  


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Thr Ser Pro Leu Asn Ile His Asn Gly Gln Lys Leu 
1               5                   10          


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Lys Lys Arg Pro Lys Pro Gly 
1               5           


<210>  16
<211>  86
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  16

Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Lys Thr Ala Cys Thr Asn Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          


His Cys Gln Val Cys Phe Ile Thr Lys Ala Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              


Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala His Gln Asn Ser Gln Thr 
    50                  55                  60                  


His Gln Ala Ser Leu Ser Lys Gln Pro Thr Ser Gln Pro Arg Gly Asp 
65                  70                  75                  80  


Pro Thr Gly Pro Lys Glu 
                85      


<210>  17
<211>  130
<212>  PRT
<213>  Human immunodeficiency virus type 2

<400>  17

Met Glu Thr Pro Leu Lys Glu Pro Glu Ser Ser Leu Glu Ser Tyr Asn 
1               5                   10                  15      


Glu Pro Ser Ser Cys Thr Ser Glu Arg Asp Val Thr Ala Gln Glu Arg 
            20                  25                  30          


Ala Lys Gln Gly Glu Glu Leu Leu Ala Gln Leu His Arg Pro Leu Glu 
        35                  40                  45              


Ala Cys Thr Asn Ser Cys Tyr Cys Lys Gln Cys Ser Tyr His Cys Gln 
    50                  55                  60                  


Leu Cys Phe Leu Lys Lys Gly Leu Gly Ile Trp Tyr Ala Arg Gln Gly 
65                  70                  75                  80  


Arg Arg Arg Arg Thr Pro Arg Lys Thr Lys Thr His Pro Pro Pro Ala 
                85                  90                  95      


Ser Asp Lys Ser Ile Ser Thr Arg Thr Gly Asp Ser Gln Pro Thr Lys 
            100                 105                 110         


Lys Gln Lys Lys Thr Pro Glu Thr Thr Val Val Ser Ala Cys Gly Leu 
        115                 120                 125             


Gly His 
    130 


<210>  18
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 
1               5                   10                  15      


Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 
            20                  25                  30          


Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 
        35                  40                  45              


Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
    50                  55                  60                  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 
65                  70                  75                  80  


Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 
                85                  90                  95      


Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 
        115                 120                 125             


Val Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 
    130                 135                 140                 


Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 
145                 150                 155                 160 


Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 
                165                 170                 175     


His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 
            180                 185                 190         


Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 
        195                 200                 205             


Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 
    210                 215                 220                 


Tyr Tyr Lys Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 
225                 230                 235                 240 


Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 
                245                 250             


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<400>  19

Gly Gly Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa 
1               5                   10                  15      


Arg 
    


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<400>  20

Gly Gly Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa 
1               5                   10                  15      


Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg 
            20                  25  


<210>  21
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<400>  21

Gly Gly Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa 
1               5                   10                  15      


Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa 
            20                  25                  30          


Arg 
    


<210>  22
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Gly Gly Glu Ser Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg 
1               5                   10                  15      


Val Ala Ser Arg Lys Ser Arg Ala Lys Phe Lys Gln Leu Leu Gln His 
            20                  25                  30          


Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser Glu Asn Asp Arg Leu Arg 
        35                  40                  45              


Leu Leu Leu Lys Gln Ser Ser 
    50                  55  


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Gly Gly Ser Arg Arg His His Ser Arg Ser Lys Ala Lys Arg Ser Arg 
1               5                   10                  15      


His His 
        


<210>  24
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Gly Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Leu Arg 
1               5                   10                  15      


Arg Arg Glu Arg Gln Ser Arg 
            20              


<210>  25
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Gly Gly Met Ala Pro Gln Arg Asp Thr Val Gly Gly Arg Thr Thr Pro 
1               5                   10                  15      


Pro Ser Trp Gly Pro Ala Lys Ala Gln Leu Arg Asn Ser Cys Ala 
            20                  25                  30      


<210>  26
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gly Gly Met Ala Pro Gln Arg Asp Thr Val Gly Gly Arg Thr Thr Pro 
1               5                   10                  15      


Pro Ser Trp Gly Pro Ala Lys Ala Gln Leu Arg Asn Ser Ser Ala 
            20                  25                  30      


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Gly Gly Phe Cys Ile Gly Arg Leu 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Gly Gly Gly Val Ile Gly Arg Leu 
1               5               


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Gly Gly Arg Ala Trp Met Arg Trp Tyr Ser Pro Thr Thr Arg Arg Tyr 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Gly Gly Pro Leu Ile Leu Leu Arg Leu Leu Arg 
1               5                   10      


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Gly Gly Met Ile Ile Tyr Arg Asp Leu Ile Ser His 
1               5                   10          


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Gly Gly Ala Cys Thr Gly Ser Thr Gln His Gln Cys Gly 
1               5                   10              


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Gly Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met 
1               5                   10                  15      


Gly Ala Pro Lys Ser Lys Arg Lys Val 
            20                  25  


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Gly Gly Leu Ile Arg Leu Trp Ser His Leu Ile His Ile Trp Phe Gln 
1               5                   10                  15      


Asn Arg Arg Leu Lys Trp Lys Lys Lys 
            20                  25  


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Gly Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala 
1               5                   10                  15      


Leu Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25          


<210>  36
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Gly Gly Leu His Lys Leu Leu His His Leu Leu His His Leu His Lys 
1               5                   10                  15      


Leu Leu His His Leu His His Leu Leu His Lys Leu 
            20                  25              


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Gly Gly Arg Lys Lys Arg 
1               5       


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gly Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gly Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Arg Lys Lys 
1               5                   10                  15      


Arg 
    


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gly Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gly Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  42
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<400>  42

Gly Gly Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa 
1               5                   10                  15      


Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Cys 
            20                  25      


<210>  43
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Boc-Lys(Fmoc)-OH

<400>  43

Gly Gly Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa 
1               5                   10                  15      


Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Cys 
            20                  25      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Gly Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  45
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Gly Gly Leu His Lys Leu Leu His His Leu Leu His His Leu His Lys 
1               5                   10                  15      


Leu Leu His His Leu His His Leu Leu His Lys Leu 
            20                  25              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gly Gly Ala Cys Thr Gly Ser Thr Gln His Gln Cys Gly 
1               5                   10              


<210>  47
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Gly Gly Leu Ile Arg Leu Trp Ser His Leu Ile His Ile Trp Phe Gln 
1               5                   10                  15      


Asn Arg Arg Leu Lys Trp Lys Lys Lys 
            20                  25  


<210>  48
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gly Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met 
1               5                   10                  15      


Gly Ala Pro Lys Ser Lys Arg Lys Val 
            20                  25  


<210>  49
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Gly Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala 
1               5                   10                  15      


Leu Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25          


<210>  50
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gly Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
1               5                   10                  15      


Gly Met Ile Asp Gly Trp Tyr Gly 
            20                  


<210>  51
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Gly Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu 
1               5                   10                  15      


Gly Met Ile Asp Gly Trp Tyr Gly 
            20                  


<210>  52
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gly Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu 
1               5                   10                  15      


Gly Met Ile Asp Gly Trp Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg 
            20                  25                  30          


Arg 
    


<210>  53
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Gly Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Trp Tyr Gly 
            20                  


<210>  54
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gly Gly Lys Trp Lys Leu Phe Lys Lys Ile Gly Ala Val Leu Lys Val 
1               5                   10                  15      


Leu Thr Thr Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25                  30      


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Ile Leu Ser Ser Leu Thr Val Thr Gln Leu Leu Arg Arg Leu His Gln 
1               5                   10                  15      


Trp Ile 
        


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Phe Ser Ser 
1               5                   10                  15      


Ala Tyr Ser 
            


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  59
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Lys Asp Glu Leu 
1               


<210>  60
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
1               5                   10                  15      


Ile Asp Gly Trp Tyr Gly Lys Asp Glu Leu 
            20                  25      


<210>  61
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
1               5                   10                  15      


Ile Asp Gly Trp Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys 
            20                  25                  30          


Asp Glu Leu 
        35  


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala 
        


<210>  64
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Lys Leu Ala Val Thr Leu Thr Leu Val Thr Leu Ala Leu Ser Ser 
1               5                   10                  15      


Ser Ser Ala Ser Ala 
            20      


<210>  65
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Phe Phe Lys Lys Leu Ala His Ala Leu His Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Ala Leu Lys Lys Ala 
            20                  25      


<210>  66
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Pro Ser Gln Pro Thr Tyr Pro Gly Asp Asp Ala Pro Val Arg Asp Leu 
1               5                   10                  15      


Ile Arg Phe Tyr Arg Asp Leu Arg Arg Tyr Leu Asn Val Val Thr Arg 
            20                  25                  30          


His Arg Tyr 
        35  


<210>  67
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp Lys Asp Glu Leu 
            20          


<210>  68
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Gly Met Ile 
1               5                   10                  15      


Asp Gly Trp Tyr Gly 
            20      


<210>  69
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
1               5                   10                  15      


Ile Asp Gly Trp Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25                  30      


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Lys Asp Glu Leu 
            20  


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Tyr Glu Gln Asp Pro Trp Gly Val Lys Trp Trp Tyr Lys 
1               5                   10              


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Lys 
    


<210>  73
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

Tyr Glu Gln Asp Pro Trp Gly Val Lys Trp Trp Tyr Lys 
1               5                   10              


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Bis-phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is Bis-phenylalanine

<400>  74

Arg Xaa Arg Xaa Arg 
1               5   


<210>  75

<400>  75
000

<210>  76
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Ile Leu Ser Ser Leu Thr Val Thr Gln Leu Leu Arg Arg Leu His Gln 
1               5                   10                  15      


Trp Ile Lys 
            


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77

Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser 
1               5                   10                  15      


Lys Asp Glu Leu 
            20  


<210>  78
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
1               5                   10                  15      


Ile Asp Gly Trp Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys 
            20                  25                  30          


Asp Glu Leu 
        35  


<210>  79
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79

Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu Ile 
1               5                   10                  15      


Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu Ile 
1               5                   10                  15      


Ser Trp Ile Lys Arg Lys Arg Gln Gln Lys Asp Glu Leu 
            20                  25                  


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81

Gly Gly Gly Pro Arg Arg Arg Arg Ser Ser Arg Arg Pro 
1               5                   10              


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Gly Gly Gly Val Arg Arg Arg Arg Arg Pro Arg Val Ser 
1               5                   10              


<210>  83
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83

Gly Gly Gly Pro Arg Arg Arg Arg Ser Ser Arg Arg Pro Val Arg Arg 
1               5                   10                  15      


Arg Arg Arg Pro Arg Val Ser 
            20              


<210>  84
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Gly Gly Gly Pro Arg Arg Arg Arg Ser Ser Arg Arg Pro Val Arg Arg 
1               5                   10                  15      


Arg Arg Arg Pro Arg Val Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg 
            20                  25                  30          


Arg Arg Arg 
        35  


<210>  85
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85

Gly Gly Ser Arg Arg His His Ser Arg Ser Lys Ala Lys Arg Ser Arg 
1               5                   10                  15      


His His 
        


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  87
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87

Gly Gly Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30          


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Gly Gly Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala 
1               5                   10                  15      


Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys Ala Leu Leu 
            20                  25                  30          


Ala 
    


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89

Arg Gly Asp Phe Lys 
1               5   


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Glu Arg Gly Asp Phe Lys Glu Arg Gly Asp Phe Lys 
1               5                   10          


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91

Cys Arg Gly Asp Arg Gly Pro Asp Cys 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92

Cys Arg Gly Asp Lys Gly Pro Asp Cys 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93

Cys Arg Asn Asp Arg Gly Pro Asp Cys 
1               5                   


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94

Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 
            20                  25                  


<210>  95
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95

Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
1               5                   10                  15      


Glu Lys Gln Glu Lys Glu Leu Met Glu Leu Glu Arg Trp Gly Ser Met 
            20                  25                  30          


Leu Lys Cys 
        35  


<210>  96
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96

Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
1               5                   10                  15      


Glu Lys Gln Glu Lys Glu Leu Met Glu Leu Glu Arg Trp Gly Ser Met 
            20                  25                  30          


Leu Gln Leu 
        35  


<210>  97
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97

Gly Gly Pro Ser Gln Pro Thr Tyr Pro Gly Asp Asp Ala Pro Val Arg 
1               5                   10                  15      


Asp Leu Ile Arg Phe Tyr Arg Asp Leu Arg Arg Tyr Leu Asn Val Val 
            20                  25                  30          


Thr Arg His Arg Tyr 
        35          


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98

Ala Ala Lys Asp Glu Leu 
1               5       


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99

Gly Glu Glu Asp Thr Ser Glu Lys Asp Glu Leu 
1               5                   10      


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp Glu Leu 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101

Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu 
1               5                   10          


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102

Gly Arg Gln Ser Asp Ile Asp Thr His Asn Arg Ile Lys Asp Glu Leu 
1               5                   10                  15      


<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105

<400>  105
000

<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106

Gly Gly Gly Gly Ser 
1               5   


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  108
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  108

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  109
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  109

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  110
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  111
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  112
gcuacauucu ggagacauau t                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113
tucgauguaa gaccucugua u                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  114
ucuacauguu ccaguaugau t                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  115
ucauacugga acauguagau t                                                 21


<210>  116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  116
ucaucacacu gaauaccaau t                                                 21


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  117
uugguauuca gugugaugau t                                                 21


<210>  118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  118
aguacugcuu acgauacggu t                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  119
ccguaucgua agcaguacuu t                                                 21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  120
aggaucaucu caagucuuau t                                                 21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  121
uaagacuuga gaugauccuu t                                                 21


