                         SEQUENCE LISTING

<110>  The Schepens Eye Research Institute, Inc.
       Stein-Streilein, Joan
       Gordon, Siamon
 
<120>  COMPOSITIONS AND METHODS FOR TREATING TUMORS AND IMMUNE BASED 
       INFLAMMATORY DISEASES

<130>  36770-546001WO

<150>  US 62/009,124
<151>  2014-06-06

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val 
465                 470                 475                 480 


Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala 
                485                 490                 495     


Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser Thr Ile Cys 
            500                 505                 510         


Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp 
        515                 520                 525             


Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Met Gly Leu 
    530                 535                 540                 


Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu 
545                 550                 555                 560 


Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser 
                565                 570                 575     


Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln 
            580                 585                 590         


Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr Leu His Tyr 
        595                 600                 605             


Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala Leu Tyr Leu 
    610                 615                 620                 


Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn 
625                 630                 635                 640 


Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala 
                645                 650                 655     


Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Thr 
            660                 665                 670         


Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe 
        675                 680                 685             


Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu 
    690                 695                 700                 


Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu 
705                 710                 715                 720 


Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala 
                725                 730                 735     


Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile Leu Gln Val 
            740                 745                 750         


Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser 
        755                 760                 765             


Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln 
    770                 775                 780                 


Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys 
785                 790                 795                 800 


Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys Ala Asp Thr 
                805                 810                 815     


Ser Lys Pro Ser Thr Val Asn 
            820             


<210>  2
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr Val Cys 
1               5                   10                  15      


Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly Trp Lys 
            20                  25                  30          


Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys Glu Asp 
        35                  40                  45              


Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln Thr 
    50                  55                  60                  


Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Tyr Lys 
65                  70                  75                  80  


Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile Leu Gln Ala Leu Asp 
                85                  90                  95      


Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr Leu Pro Arg Leu Gln 
            100                 105                 110         


Gln His Cys Val Ala Ser His Leu Leu Asp Gly Leu Glu Asp Val Leu 
        115                 120                 125             


Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu Leu Asn Phe Ser Tyr 
    130                 135                 140                 


Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln Lys Gln Val Asp Arg 
145                 150                 155                 160 


Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met Gln Leu Asp Trp Asn 
                165                 170                 175     


Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser Val Val Gly Leu Val 
            180                 185                 190         


Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu Ala Pro Leu Val Leu 
        195                 200                 205             


Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr His Gln Gly Leu Leu 
    210                 215                 220                 


Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val Ile Ser Ala Phe Leu 
225                 230                 235                 240 


Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro Val Thr Phe Thr Phe 
                245                 250                 255     


Ser His Arg Ser Val Ile Pro Arg Gln Lys Val 
            260                 265         


<210>  3
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Met Gly 
385                 390                 395                 400 


Lys Leu Leu Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met 
                405                 410                 415     


Leu Leu His Glu Thr His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile 
            420                 425                 430         


Leu Leu Ser Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln 
        435                 440                 445             


Asn Leu Ser Ser Pro Val Thr Phe Thr Phe Ser His Arg Ser Val Ile 
    450                 455                 460                 


Pro Arg Gln Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly 
465                 470                 475                 480 


Cys Gly His Trp Ala Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp 
                485                 490                 495     


Thr Ser Thr Ile Cys Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu 
            500                 505                 510         


Met Ala His Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile 
        515                 520                 525             


Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala 
    530                 535                 540                 


Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu 
545                 550                 555                 560 


His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu 
                565                 570                 575     


Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala 
            580                 585                 590         


Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu 
        595                 600                 605             


Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn 
    610                 615                 620                 


Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly 
625                 630                 635                 640 


Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro 
                645                 650                 655     


His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly 
            660                 665                 670         


Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn 
        675                 680                 685             


Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser 
    690                 695                 700                 


Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala 
705                 710                 715                 720 


Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu 
                725                 730                 735     


Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe 
            740                 745                 750         


Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys 
        755                 760                 765             


Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly 
    770                 775                 780                 


Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser 
785                 790                 795                 800 


Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
                805                 810         


<210>  4
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser 
                165                 170                 175     


Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr 
        195                 200                 205             


Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val 
    210                 215                 220                 


His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly 
225                 230                 235                 240 


Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile Leu 
                245                 250                 255     


Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr Leu 
            260                 265                 270         


Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly Leu 
        275                 280                 285             


Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu Leu 
    290                 295                 300                 


Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln Lys 
305                 310                 315                 320 


Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met Gln 
                325                 330                 335     


Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser Val 
            340                 345                 350         


Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu Ala 
        355                 360                 365             


Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr His 
    370                 375                 380                 


Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val Ile 
385                 390                 395                 400 


Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro Val 
                405                 410                 415     


Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val Leu 
            420                 425                 430         


Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala Thr 
        435                 440                 445             


Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser Thr Ile Cys Arg 
    450                 455                 460                 


Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp Val 
465                 470                 475                 480 


Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Met Gly Leu Ser 
                485                 490                 495     


Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu Cys 
            500                 505                 510         


Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser Leu 
        515                 520                 525             


Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln Thr 
    530                 535                 540                 


Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr Leu His Tyr Leu 
545                 550                 555                 560 


Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala Leu Tyr Leu Phe 
                565                 570                 575     


Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn Arg 
            580                 585                 590         


Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala Val 
        595                 600                 605             


Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Thr Pro 
    610                 615                 620                 


Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe Leu 
625                 630                 635                 640 


Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu Val 
                645                 650                 655     


Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu Val 
            660                 665                 670         


Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala Gln 
        675                 680                 685             


Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile Leu Gln Val Gly 
    690                 695                 700                 


Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu 
705                 710                 715                 720 


Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln Val 
                725                 730                 735     


Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys Thr 
            740                 745                 750         


Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys Ala Asp Thr Ser 
        755                 760                 765             


Lys Pro Ser Thr Val Asn 
    770                 


<210>  5
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Ser Ser Gly Gln His 
        115                 120                 125             


Gln Cys Asp Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser 
    130                 135                 140                 


Cys Arg Cys Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn 
145                 150                 155                 160 


Gln Lys Asp Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro 
                165                 170                 175     


Pro Pro Gly Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val 
            180                 185                 190         


Gln Asp Leu Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile 
        195                 200                 205             


Gln Ser Ile Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp 
    210                 215                 220                 


Leu Glu Thr Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu 
225                 230                 235                 240 


Leu Asp Gly Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser 
                245                 250                 255     


Asn Gly Leu Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu 
            260                 265                 270         


Glu Val Gln Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln 
        275                 280                 285             


Ala Val Met Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro 
    290                 295                 300                 


Gly Pro Ser Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu 
305                 310                 315                 320 


Leu Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu 
                325                 330                 335     


His Glu Thr His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu 
            340                 345                 350         


Ser Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu 
        355                 360                 365             


Ser Ser Pro Val Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg 
    370                 375                 380                 


Gln Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly 
385                 390                 395                 400 


His Trp Ala Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser 
                405                 410                 415     


Thr Ile Cys Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala 
            420                 425                 430         


His Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr 
        435                 440                 445             


Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr 
    450                 455                 460                 


Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu 
465                 470                 475                 480 


Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala 
                485                 490                 495     


Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr 
            500                 505                 510         


Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala 
        515                 520                 525             


Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser 
    530                 535                 540                 


Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly 
545                 550                 555                 560 


Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu 
                565                 570                 575     


Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile 
            580                 585                 590         


Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val 
        595                 600                 605             


Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu 
    610                 615                 620                 


Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys 
625                 630                 635                 640 


Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile 
                645                 650                 655     


Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile 
            660                 665                 670         


Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu 
        675                 680                 685             


Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg 
    690                 695                 700                 


Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys 
705                 710                 715                 720 


Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
                725                 730 


<210>  6
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Met Thr Phe Ser Thr Trp Thr Pro Pro 
        115                 120                 125             


Pro Gly Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln 
    130                 135                 140                 


Asp Leu Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln 
145                 150                 155                 160 


Ser Ile Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu 
                165                 170                 175     


Glu Thr Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu 
            180                 185                 190         


Asp Gly Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn 
        195                 200                 205             


Gly Leu Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu 
    210                 215                 220                 


Val Gln Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala 
225                 230                 235                 240 


Val Met Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly 
                245                 250                 255     


Pro Ser Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu 
            260                 265                 270         


Ala Glu Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His 
        275                 280                 285             


Glu Thr His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser 
    290                 295                 300                 


Asp Val Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser 
305                 310                 315                 320 


Ser Pro Val Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg Gln 
                325                 330                 335     


Lys Val Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His 
            340                 345                 350         


Trp Ala Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser Thr 
        355                 360                 365             


Ile Cys Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala His 
    370                 375                 380                 


Tyr Asp Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Met 
385                 390                 395                 400 


Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe 
                405                 410                 415     


Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu Gln 
            420                 425                 430         


Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile 
        435                 440                 445             


Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr Leu 
    450                 455                 460                 


His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser 
                485                 490                 495     


Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val 
            500                 505                 510         


Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr 
        515                 520                 525             


Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp 
    530                 535                 540                 


Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu 
545                 550                 555                 560 


Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn 
                565                 570                 575     


Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys Ala 
            580                 585                 590         


Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile Leu 
        595                 600                 605             


Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile Ile 
    610                 615                 620                 


Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser 
625                 630                 635                 640 


Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys 
                645                 650                 655     


Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys Ala 
            660                 665                 670         


Asp Thr Ser Lys Pro Ser Thr Val Asn 
        675                 680     


<210>  7
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  8
<211>  6024
<212>  DNA
<213>  Homo sapiens

<400>  8
ctgcaccgcc agttccgggg agggccctgg gccagcggct gtccgccccc cctcctttat       60

aaagtcctgg cctcgggaca gcccgcacag ctgcccagcc tgcggagacg ggacagccct      120

gtcccactca ctctttcccc tgctgctcct gccggcagct cagctggaac catgggaggc      180

cgcgtctttc tcgtctttct cgcattctgt gtctggctga ctctgccggg agctgaaacc      240

caggactcca ggggctgtgc ccggtggtgc cctcaggact cctcgtgtgt caatgccacc      300

gcctgtcgct gcaatccagg gttcagctct ttttctgaga tcatcaccac ccccatggag      360

acttgtgacg acatcaacga gtgtgcaaca ctgtcgaaag tgtcatgcgg aaaattctcg      420

gactgctgga acacagaggg gagctacgac tgcgtgtgca gcccaggata tgagcctgtt      480

tctggggcaa aaacattcaa gaatgagagc gagaacacgt gtcaagatgt ggacgaatgt      540

cagcagaacc caaggctctg taaaagctac ggcacctgcg tcaacaccct cggcagctac      600

acgtgccagt gcctgcctgg cttcaagctc aaacctgagg acccgaagct ctgcacagat      660

gtgaatgaat gcacctccgg acaaaaccca tgccacagct ccacccactg cctcaacaac      720

gtgggcagct atcagtgccg ctgccgcccg ggctggcaac cgattccggg gtcccccaat      780

ggcccaaaca ataccgtctg tgaagatgtg gacgagtgca gctccgggca gcatcagtgt      840

gacagctcca ccgtctgctt caacaccgtg ggttcataca gctgccgctg ccgcccaggc      900

tggaagccca gacacggaat cccgaataac caaaaggaca ctgtctgtga agatatgact      960

ttctccacct ggaccccgcc ccctggagtc cacagccaga cgctttcccg attcttcgac     1020

aaagtccagg acctgggcag agactacaag ccaggcttgg ccaataacac catccagagc     1080

atcttacagg cgctggatga gctgctggag gcccctgggg acctggagac cctgccccgc     1140

ttacagcagc actgtgtggc cagtcacctg ctggatggcc tagaggatgt cctcagaggc     1200

ctgagcaaga acctttccaa tgggctgttg aacttcagtt atcctgcagg cacagaattg     1260

tccctggagg tgcagaagca agtagacagg agtgtcacct tgagacagaa tcaggcagtg     1320

atgcagctcg actggaatca ggcacagaaa tctggtgacc caggcccttc tgtggtgggc     1380

cttgtctcca ttccagggat gggcaagttg ctggctgagg cccctctggt cctggaacct     1440

gagaagcaga tgcttctgca tgagacacac cagggcttgc tgcaggacgg ctcccccatc     1500

ctgctctcag atgtgatctc tgcctttctg agcaacaacg acacccaaaa cctcagctcc     1560

ccagttacct tcaccttctc ccaccgtgag gaggatcccg tgctgactgt catcacctac     1620

atggggctga gcgtctctct gctgtgcctc ctcctggcgg ccctcacttt tctcctgtgt     1680

aaagccatcc agaacaccag cacctcactg catctgcagc tctcgctctg cctcttcctg     1740

gcccacctcc tcttcctcgt ggcaattgat caaaccggac acaaggtgct gtgctccatc     1800

atcgccggta ccttgcacta tctctacctg gccaccttga cctggatgct gctggaggcc     1860

ctgtacctct tcctcactgc acggaacctg acggtggtca actactcaag catcaacaga     1920

ttcatgaaga agctcatgtt ccctgtgggc tacggagtcc cagctgtgac agtggccatt     1980

tctgcagcct ccaggcctca cctttatgga acaccttccc gctgctggct ccaaccagaa     2040

aagggattta tatggggctt ccttggacct gtctgcgcca tcttctctgt gaatttagtt     2100

ctctttctgg tgactctctg gattttgaaa aacagactct cctccctcaa tagtgaagtg     2160

tccaccctcc ggaacacaag gatgctggca tttaaagcga cagctcagct gttcatcctg     2220

ggctgcacgt ggtgtctggg catcttgcag gtgggtccgg ctgcccgggt catggcctac     2280

ctcttcacca tcatcaacag cctgcagggt gtcttcatct tcctggtgta ctgcctcctc     2340

agccagcagg tccgggagca atatgggaaa tggtccaaag ggatcaggaa attgaaaact     2400

gagtctgaga tgcacacact ctccagcagt gctaaggctg acacctccaa acccagcacg     2460

gttaactaga aaaatcttct gaataagatc ttccctcttt gcccgtggaa aatctgaaca     2520

atctttgagc catctagagg ggaaagaaaa gactttgttc tgtgtgtttc aagaaattca     2580

ccatgtcagc aatatgaagg atgttatgga aggcgtgcta ggcattcaat tcctgcagaa     2640

accggaaatc ttccatgccc tgcaatgtgc tcatcaaact ctcagcatat ggacggccag     2700

ctgtggccca tatcttggtc actctgaagc acaatattta tgaagctata gaacgttaag     2760

acctctttca cagcctctcc ttcctacaaa gactcctcca aatcttaaaa tgaagcagga     2820

aaacgagcct aagaggactt tcataccgac aacatctgaa aggactagaa tgttcacacc     2880

acgatctgga tttcttaatt ttttgttttt gtttttgttg ttctctagtt ctacgggttt     2940

gattatttag tcatgtgaaa aatattgatt actcacacat agatcaagag agacacggct     3000

cctgccttca tggagctttt aggggaaaat gaagtggctc ttgcagctag agttgactca     3060

gaagccgaaa ttcctagaaa tcaggtttct actgctaggc aattgaagta taaactattt     3120

tataaacact gtcttctttc gtcttcacac caacatgcag aaaagtttct aatctcagat     3180

cggggatgtg caacaaattc catttcaaag gaatgacctg caaaactcct aaatattcca     3240

agcaaatgcc cttaaccctg tctgttatct gctttccttg aacagaaatt ctacatgacc     3300

ataaaacctc gaagatgggt atggcacagt tcatgccctg taatcctagc actttgggag     3360

ggtgaggcag gaggatggct caagcccagg agtttgagac cagtgtgggc aacagagtga     3420

gaaccatctc tacccaaaaa aaaaattaaa aattagccaa gcatggtgat gatataggag     3480

ttaaggagaa atcatttagg caaatagcaa gggtaggaag tcctcagtaa ggttttccat     3540

ttaatgaaaa gcagccccca aaatcatttt cttttctaac aaagaacagc ctgtaaaatc     3600

gagctgcaga catagacaag caagctggaa gcttccacgg gtgaatgccg gcagctgtgc     3660

caataggaaa aagctaccta gactaggcat gtccaaaatg gcggctccaa gttcccttct     3720

ctttgccagc catgtgtaca gtaaaaagca ggcaacatag tgtcagccaa agctcatttg     3780

cataataaga ttagggtggg gtggccagct cacatagggg taggccctag gtaaatcaga     3840

caccgccttc tcaagcctgt ctataaaatc tggtacacta tgacgagggt cagatttccc     3900

attcagacgc ccctctccca tgcaagagaa agagctgttc tcctttctct ttcttttgcc     3960

tattaaacct ctgctcctgg ccaggcacag tggctcacgc ctataatccc agcactttgg     4020

gaggctgagg tggtcagatc acctaaggtc aggagttcaa gaccagcctg gtcaacatgg     4080

tgaaatcttg tctctagtaa aaatacaaaa atatatgaaa tctcacatag atgataatat     4140

taagttccaa aagcaactca acctggtaga ttctaatttt ttttgaggca gggtcttgct     4200

ttgtcaccca tgctggagta caatggcaca aacactgctc actgcagcct cgacctccca     4260

aggcctaagc aatcctcctg cctcagtccc cctccaggta tttgaaacta caggtgtgta     4320

ccaccacacc gggctaattt ttgtattttt tgtagagacg tgggtctcac tatgctgccc     4380

aggctcaggt cttaatctcc tgagctcagg caatccgcag gcctcagcct ccctaagtgc     4440

ggggattaca ggcttgagcc actgcaccta gcctctattt gttttacaaa agagaaattg     4500

agatcctgaa tgttaagtga cttgcctgag gccatcccac taacaggagc cagggttagg     4560

attcaaaccc catccaactg gtcccagagc tggagcttct tgcactgccc tacactacct     4620

accatctcca tcctctgggc acctttttat aagaaccaaa acattacaga gcattgcttt     4680

gtcaactcag ctgggaacat ttcccagtgc aactcacatt tttcactgct ctgtgcctgt     4740

ccgtataagc tcaatgagta ttgatttagg ggctttggag aactttgaat gctacccccc     4800

aagtaaccat tgttggcaac ctggtacctc tacttttagc catttctcct tctctataaa     4860

tagtgcagaa gtaacccact tggtaacagg catccttgcc aagcctccac cactaggtca     4920

gtgtaagaat taaagaaaga ggaaagaaac acaaaaagtg gcttgatggt taagacaggt     4980

ttattttaga gaaaacacac ctgagagggg ctgctggctg aattaggtta gagtcttttc     5040

tacagactaa gagtgtttaa ggatttaggg tgggagagtt tcttagaggc ttggactgct     5100

tctgtgtttt ttttgttgtg cttatatggg agggagagtg gtgtgtttgc ttttatacat     5160

ttttctgcag ctgtaggcat accccccaag tctgctttta gcttccctat tttagtgcac     5220

ctggagggaa aggaatgtgc ttattaaggc ccactgtttt actggggccc attgtatgag     5280

ggtgaagttt ggcagttacc caagagactt ttcctccacc ttcctctgtg cccgagctgt     5340

tttatctgca ttttactgtc tgcttttttt ggctgcttat agtttttaaa aaagtaattt     5400

ccttaaatcc agaaggctaa aaatgaagct gaaacttaaa gtggcggtgt ttgtccaaaa     5460

taacggggct cctgctctgc cagtcagtac cctcaagtca ctcctgatcc tcaacctcca     5520

tgcctaaggc tggttcaaga gaccacataa tatctgcctt ttattacata catgatgggt     5580

gcatgggatt ctgcgtgccc tttgcttgat atagactgct aaggtgagat ggggaatatc     5640

agagtcagct gctgcttgag gaagcagaac acacagctgg aggcttggaa catgtgggtc     5700

cctatgagtg tagagcccat atccccatag agtctaccta gagcaggggt cgccaaatgt     5760

tttcttaaag agcctgatag tgtatatgtt aggctttgtg agccaggtat ttacagcaac     5820

tcaattctac cactgtggta tgaaaacagc tatagacaat cataaatgaa tgatcatggc     5880

tatgttttaa taaaacttta cagacactga acttgaactt ccattgtgat atgaaaacag     5940

ctatagacaa tcataaatga atgatcatgg ctatgtttta ataaaacttt atggacactg     6000

agcttgaaaa aaaaaaaaaa aaaa                                            6024


<210>  9
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  10
<211>  6483
<212>  DNA
<213>  Homo sapiens

<400>  10
ggggggtctg ctctgtgcgg tgaagcttct cttcttggca cctgcctggc atcggaagag       60

ggccccttct ccctccctgg gcttttatgt ggacactgta atgcctcagt tttctttctt      120

tctttttgtt tttgacacag ggtctcactc tatcacccaa gctggagtgc agtggcacca      180

tcttagctca ccgcagcctc aaactcccca gctcgggtga ttcttcctgc ctcagcctcc      240

tgagtagtag cagctgggac cacagacgtc tgccaccaag cccagctgca ccgccagttc      300

cggggagggc cctgggccag cggctgtccg ccccccctcc tttataaagt cctggcctcg      360

ggacagcccg cacagctgcc cagcctgcgg agacgggaca gccctgtccc actcactctt      420

tcccctgctg ctcctgccgg cagctcagct ggaaccatgg gaggccgcgt ctttctcgtc      480

tttctcgcat tctgtgtctg gctgactctg ccgggagctg aaacccagga ctccaggggc      540

tgtgcccggt ggtgccctca ggactcctcg tgtgtcaatg ccaccgcctg tcgctgcaat      600

ccagggttca gctctttttc tgagatcatc accaccccca tggagacttg tgacgacatc      660

aacgagtgtg caacactgtc gaaagtgtca tgcggaaaat tctcggactg ctggaacaca      720

gaggggagct acgactgcgt gtgcagccca ggatatgagc ctgtttctgg ggcaaaaaca      780

ttcaagaatg agagcgagaa cacgtgtcaa gatgtggacg aatgtcagca gaacccaagg      840

ctctgtaaaa gctacggcac ctgcgtcaac accctcggca gctacacgtg ccagtgcctg      900

cctggcttca agctcaaacc tgaggacccg aagctctgca cagatgtgaa tgaatgcacc      960

tccggacaaa acccatgcca cagctccacc cactgcctca acaacgtggg cagctatcag     1020

tgccgctgcc gcccgggctg gcaaccgatt ccggggtccc ccaatggccc aaacaatacc     1080

gtctgtgaag atgtggacga gtgcagctcc gggcagcatc agtgtgacag ctccaccgtc     1140

tgcttcaaca ccgtgggttc atacagctgc cgctgccgcc caggctggaa gcccagacac     1200

ggaatcccga ataaccaaaa ggacactgtc tgtgaagata tgactttctc cacctggacc     1260

ccgccccctg gagtccacag ccagacgctt tcccgattct tcgacaaagt ccaggacctg     1320

ggcagagact acaagccagg cttggccaat aacaccatcc agagcatctt acaggcgctg     1380

gatgagctgc tggaggcccc tggggacctg gagaccctgc cccgcttaca gcagcactgt     1440

gtggccagtc acctgctgga tggcctagag gatgtcctca gaggcctgag caagaacctt     1500

tccaatgggc tgttgaactt cagttatcct gcaggcacag aattgtccct ggaggtgcag     1560

aagcaagtag acaggagtgt caccttgaga cagaatcagg cagtgatgca gctcgactgg     1620

aatcaggcac agaaatctgg tgacccaggc ccttctgtgg tgggccttgt ctccattcca     1680

gggatgggca agttgctggc tgaggcccct ctggtcctgg aacctgagaa gcagatgctt     1740

ctgcatgaga cacaccaggg cttgctgcag gacggctccc ccatcctgct ctcagatgtg     1800

atctctgcct ttctgagcaa caacgacacc caaaacctca gctccccagt taccttcacc     1860

ttctcccacc gttcagtgat cccgagacag aaggtgctct gtgtcttctg ggagcatggc     1920

cagaatggat gtggtcactg ggccaccaca ggctgcagca caataggcac cagagacacc     1980

agcaccatct gccgttgcac ccacctgagc agctttgccg tcctcatggc ccactacgat     2040

gtgcaggagg aggatcccgt gctgactgtc atcacctaca tggggctgag cgtctctctg     2100

ctgtgcctcc tcctggcggc cctcactttt ctcctgtgta aagccatcca gaacaccagc     2160

acctcactgc atctgcagct ctcgctctgc ctcttcctgg cccacctcct cttcctcgtg     2220

gcaattgatc aaaccggaca caaggtgctg tgctccatca tcgccggtac cttgcactat     2280

ctctacctgg ccaccttgac ctggatgctg ctggaggccc tgtacctctt cctcactgca     2340

cggaacctga cggtggtcaa ctactcaagc atcaacagat tcatgaagaa gctcatgttc     2400

cctgtgggct acggagtccc agctgtgaca gtggccattt ctgcagcctc caggcctcac     2460

ctttatggaa caccttcccg ctgctggctc caaccagaaa agggatttat atggggcttc     2520

cttggacctg tctgcgccat cttctctgtg aatttagttc tctttctggt gactctctgg     2580

attttgaaaa acagactctc ctccctcaat agtgaagtgt ccaccctccg gaacacaagg     2640

atgctggcat ttaaagcgac agctcagctg ttcatcctgg gctgcacgtg gtgtctgggc     2700

atcttgcagg tgggtccggc tgcccgggtc atggcctacc tcttcaccat catcaacagc     2760

ctgcagggtg tcttcatctt cctggtgtac tgcctcctca gccagcaggt ccgggagcaa     2820

tatgggaaat ggtccaaagg gatcaggaaa ttgaaaactg agtctgagat gcacacactc     2880

tccagcagtg ctaaggctga cacctccaaa cccagcacgg ttaactagaa aaatcttctg     2940

aataagatct tccctctttg cccgtggaaa atctgaacaa tctttgagcc atctagaggg     3000

gaaagaaaag actttgttct gtgtgtttca agaaattcac catgtcagca atatgaagga     3060

tgttatggaa ggcgtgctag gcattcaatt cctgcagaaa ccggaaatct tccatgccct     3120

gcaatgtgct catcaaactc tcagcatatg gacggccagc tgtggcccat atcttggtca     3180

ctctgaagca caatatttat gaagctatag aacgttaaga cctctttcac agcctctcct     3240

tcctacaaag actcctccaa atcttaaaat gaagcaggaa aacgagccta agaggacttt     3300

cataccgaca acatctgaaa ggactagaat gttcacacca cgatctggat ttcttaattt     3360

tttgtttttg tttttgttgt tctctagttc tacgggtttg attatttagt catgtgaaaa     3420

atattgatta ctcacacata gatcaagaga gacacggctc ctgccttcat ggagctttta     3480

ggggaaaatg aagtggctct tgcagctaga gttgactcag aagccgaaat tcctagaaat     3540

caggtttcta ctgctaggca attgaagtat aaactatttt ataaacactg tcttctttcg     3600

tcttcacacc aacatgcaga aaagtttcta atctcagatc ggggatgtgc aacaaattcc     3660

atttcaaagg aatgacctgc aaaactccta aatattccaa gcaaatgccc ttaaccctgt     3720

ctgttatctg ctttccttga acagaaattc tacatgacca taaaacctcg aagatgggta     3780

tggcacagtt catgccctgt aatcctagca ctttgggagg gtgaggcagg aggatggctc     3840

aagcccagga gtttgagacc agtgtgggca acagagtgag aaccatctct acccaaaaaa     3900

aaaattaaaa attagccaag catggtgatg atataggagt taaggagaaa tcatttaggc     3960

aaatagcaag ggtaggaagt cctcagtaag gttttccatt taatgaaaag cagcccccaa     4020

aatcattttc ttttctaaca aagaacagcc tgtaaaatcg agctgcagac atagacaagc     4080

aagctggaag cttccacggg tgaatgccgg cagctgtgcc aataggaaaa agctacctag     4140

actaggcatg tccaaaatgg cggctccaag ttcccttctc tttgccagcc atgtgtacag     4200

taaaaagcag gcaacatagt gtcagccaaa gctcatttgc ataataagat tagggtgggg     4260

tggccagctc acataggggt aggccctagg taaatcagac accgccttct caagcctgtc     4320

tataaaatct ggtacactat gacgagggtc agatttccca ttcagacgcc cctctcccat     4380

gcaagagaaa gagctgttct cctttctctt tcttttgcct attaaacctc tgctcctggc     4440

caggcacagt ggctcacgcc tataatccca gcactttggg aggctgaggt ggtcagatca     4500

cctaaggtca ggagttcaag accagcctgg tcaacatggt gaaatcttgt ctctagtaaa     4560

aatacaaaaa tatatgaaat ctcacataga tgataatatt aagttccaaa agcaactcaa     4620

cctggtagat tctaattttt tttgaggcag ggtcttgctt tgtcacccat gctggagtac     4680

aatggcacaa acactgctca ctgcagcctc gacctcccaa ggcctaagca atcctcctgc     4740

ctcagtcccc ctccaggtat ttgaaactac aggtgtgtac caccacaccg ggctaatttt     4800

tgtatttttt gtagagacgt gggtctcact atgctgccca ggctcaggtc ttaatctcct     4860

gagctcaggc aatccgcagg cctcagcctc cctaagtgcg gggattacag gcttgagcca     4920

ctgcacctag cctctatttg ttttacaaaa gagaaattga gatcctgaat gttaagtgac     4980

ttgcctgagg ccatcccact aacaggagcc agggttagga ttcaaacccc atccaactgg     5040

tcccagagct ggagcttctt gcactgccct acactaccta ccatctccat cctctgggca     5100

cctttttata agaaccaaaa cattacagag cattgctttg tcaactcagc tgggaacatt     5160

tcccagtgca actcacattt ttcactgctc tgtgcctgtc cgtataagct caatgagtat     5220

tgatttaggg gctttggaga actttgaatg ctacccccca agtaaccatt gttggcaacc     5280

tggtacctct acttttagcc atttctcctt ctctataaat agtgcagaag taacccactt     5340

ggtaacaggc atccttgcca agcctccacc actaggtcag tgtaagaatt aaagaaagag     5400

gaaagaaaca caaaaagtgg cttgatggtt aagacaggtt tattttagag aaaacacacc     5460

tgagaggggc tgctggctga attaggttag agtcttttct acagactaag agtgtttaag     5520

gatttagggt gggagagttt cttagaggct tggactgctt ctgtgttttt tttgttgtgc     5580

ttatatggga gggagagtgg tgtgtttgct tttatacatt tttctgcagc tgtaggcata     5640

ccccccaagt ctgcttttag cttccctatt ttagtgcacc tggagggaaa ggaatgtgct     5700

tattaaggcc cactgtttta ctggggccca ttgtatgagg gtgaagtttg gcagttaccc     5760

aagagacttt tcctccacct tcctctgtgc ccgagctgtt ttatctgcat tttactgtct     5820

gctttttttg gctgcttata gtttttaaaa aagtaatttc cttaaatcca gaaggctaaa     5880

aatgaagctg aaacttaaag tggcggtgtt tgtccaaaat aacggggctc ctgctctgcc     5940

agtcagtacc ctcaagtcac tcctgatcct caacctccat gcctaaggct ggttcaagag     6000

accacataat atctgccttt tattacatac atgatgggtg catgggattc tgcgtgccct     6060

ttgcttgata tagactgcta aggtgagatg gggaatatca gagtcagctg ctgcttgagg     6120

aagcagaaca cacagctgga ggcttggaac atgtgggtcc ctatgagtgt agagcccata     6180

tccccataga gtctacctag agcaggggtc gccaaatgtt ttcttaaaga gcctgatagt     6240

gtatatgtta ggctttgtga gccaggtatt tacagcaact caattctacc actgtggtat     6300

gaaaacagct atagacaatc ataaatgaat gatcatggct atgttttaat aaaactttac     6360

agacactgaa cttgaacttc cattgtgata tgaaaacagc tatagacaat cataaatgaa     6420

tgatcatggc tatgttttaa taaaacttta tggacactga gcttgaaaaa aaaaaaaaaa     6480

aaa                                                                   6483


<210>  11
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Ser Val Ile Pro Arg Gln Lys Val 
465                 470                 475                 480 


Leu Cys Val Phe Trp Glu His Gly Gln Asn Gly Cys Gly His Trp Ala 
                485                 490                 495     


Thr Thr Gly Cys Ser Thr Ile Gly Thr Arg Asp Thr Ser Thr Ile Cys 
            500                 505                 510         


Arg Cys Thr His Leu Ser Ser Phe Ala Val Leu Met Ala His Tyr Asp 
        515                 520                 525             


Val Gln Glu Glu Asp Pro Val Leu Thr Val Ile Thr Tyr Met Gly Leu 
    530                 535                 540                 


Ser Val Ser Leu Leu Cys Leu Leu Leu Ala Ala Leu Thr Phe Leu Leu 
545                 550                 555                 560 


Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser Leu His Leu Gln Leu Ser 
                565                 570                 575     


Leu Cys Leu Phe Leu Ala His Leu Leu Phe Leu Val Ala Ile Asp Gln 
            580                 585                 590         


Thr Gly His Lys Val Leu Cys Ser Ile Ile Ala Gly Thr Leu His Tyr 
        595                 600                 605             


Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu Leu Glu Ala Leu Tyr Leu 
    610                 615                 620                 


Phe Leu Thr Ala Arg Asn Leu Thr Val Val Asn Tyr Ser Ser Ile Asn 
625                 630                 635                 640 


Arg Phe Met Lys Lys Leu Met Phe Pro Val Gly Tyr Gly Val Pro Ala 
                645                 650                 655     


Val Thr Val Ala Ile Ser Ala Ala Ser Arg Pro His Leu Tyr Gly Thr 
            660                 665                 670         


Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys Gly Phe Ile Trp Gly Phe 
        675                 680                 685             


Leu Gly Pro Val Cys Ala Ile Phe Ser Val Asn Leu Val Leu Phe Leu 
    690                 695                 700                 


Val Thr Leu Trp Ile Leu Lys Asn Arg Leu Ser Ser Leu Asn Ser Glu 
705                 710                 715                 720 


Val Ser Thr Leu Arg Asn Thr Arg Met Leu Ala Phe Lys Ala Thr Ala 
                725                 730                 735     


Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys Leu Gly Ile Leu Gln Val 
            740                 745                 750         


Gly Pro Ala Ala Arg Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser 
        755                 760                 765             


Leu Gln Gly Val Phe Ile Phe Leu Val Tyr Cys Leu Leu Ser Gln Gln 
    770                 775                 780                 


Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys Gly Ile Arg Lys Leu Lys 
785                 790                 795                 800 


Thr Glu Ser Glu Met His Thr Leu Ser Ser Ser Ala Lys Ala Asp Thr 
                805                 810                 815     


Ser Lys Pro Ser Thr Val Asn 
            820             


<210>  12
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
augcugacau auuuacuaga gg                                                22


<210>  13
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
agccgtgtct ctcttgatct atgtgt                                            26


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
ggcatttgct tggaatattt agg                                               23


