                               SEQUENCE LISTING

<110> ABBVIE INC.
 
<120> SYK-DEPENDENT HS1 TYROSINE PHOSPHORYLATION AND USES THEREOF

<130> 117813-71320

<140> PCT/US2015/033890
<141> 2015-06-03

<150> 62/007,969
<151> 2014-06-05

<160> 1     

<170> PatentIn version 3.5

<210> 1
<211> 486
<212> PRT
<213> Homo sapiens

<400> 1
Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15      


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30          


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45              


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60                  


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80  


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95      


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110         


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125             


Asp Arg Ala Asp Lys Ser Ala Val Gly Phe Asp Tyr Lys Gly Glu Val 
    130                 135                 140                 


Glu Lys His Thr Ser Gln Lys Asp Tyr Ser Arg Gly Phe Gly Gly Arg 
145                 150                 155                 160 


Tyr Gly Val Glu Lys Asp Lys Trp Asp Lys Ala Ala Leu Gly Tyr Asp 
                165                 170                 175     


Tyr Lys Gly Glu Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ala Lys 
            180                 185                 190         


Gly Phe Gly Gly Gln Tyr Gly Ile Gln Lys Asp Arg Val Asp Lys Ser 
        195                 200                 205             


Ala Val Gly Phe Asn Glu Met Glu Ala Pro Thr Thr Ala Tyr Lys Lys 
    210                 215                 220                 


Thr Thr Pro Ile Glu Ala Ala Ser Ser Gly Thr Arg Gly Leu Lys Ala 
225                 230                 235                 240 


Lys Phe Glu Ser Met Ala Glu Glu Lys Arg Lys Arg Glu Glu Glu Glu 
                245                 250                 255     


Lys Ala Gln Gln Val Ala Arg Arg Gln Gln Glu Arg Lys Ala Val Thr 
            260                 265                 270         


Lys Arg Ser Pro Glu Ala Pro Gln Pro Val Ile Ala Met Glu Glu Pro 
        275                 280                 285             


Ala Val Pro Ala Pro Leu Pro Lys Lys Ile Ser Ser Glu Ala Trp Pro 
    290                 295                 300                 


Pro Val Gly Thr Pro Pro Ser Ser Glu Ser Glu Pro Val Arg Thr Ser 
305                 310                 315                 320 


Arg Glu His Pro Val Pro Leu Leu Pro Ile Arg Gln Thr Leu Pro Glu 
                325                 330                 335     


Asp Asn Glu Glu Pro Pro Ala Leu Pro Pro Arg Thr Leu Glu Gly Leu 
            340                 345                 350         


Gln Val Glu Glu Glu Pro Val Tyr Glu Ala Glu Pro Glu Pro Glu Pro 
        355                 360                 365             


Glu Pro Glu Pro Glu Pro Glu Asn Asp Tyr Glu Asp Val Glu Glu Met 
    370                 375                 380                 


Asp Arg His Glu Gln Glu Asp Glu Pro Glu Gly Asp Tyr Glu Glu Val 
385                 390                 395                 400 


Leu Glu Pro Glu Asp Ser Ser Phe Ser Ser Ala Leu Ala Gly Ser Ser 
                405                 410                 415     


Gly Cys Pro Ala Gly Ala Gly Ala Gly Ala Val Ala Leu Gly Ile Ser 
            420                 425                 430         


Ala Val Ala Leu Tyr Asp Tyr Gln Gly Glu Gly Ser Asp Glu Leu Ser 
        435                 440                 445             


Phe Asp Pro Asp Asp Val Ile Thr Asp Ile Glu Met Val Asp Glu Gly 
    450                 455                 460                 


Trp Trp Arg Gly Arg Cys His Gly His Phe Gly Leu Phe Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Lys Leu Leu Glu 
                485     


