                         SEQUENCE LISTING

<110>  Crawley, Suzanne C
       Hsu, Jer-Yuan
       Tian, Hui
 
<120>  Compositions and Methods for Targeting a Pathway

<130>  NGMB-141WO

<150>  US 62/007,795
<151>  2014-06-04

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  2
<211>  1093
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Pro Val Arg Gly Gly Leu Gly Ala Pro Arg Arg Ser Pro 
1               5                   10                  15      


Cys Leu Leu Leu Leu Trp Leu Leu Leu Leu Arg Leu Glu Pro Val Thr 
            20                  25                  30          


Ala Ala Ala Gly Pro Arg Ala Pro Cys Ala Ala Ala Cys Thr Cys Ala 
        35                  40                  45              


Gly Asp Ser Leu Asp Cys Gly Gly Arg Gly Leu Ala Ala Leu Pro Gly 
    50                  55                  60                  


Asp Leu Pro Ser Trp Thr Arg Ser Leu Asn Leu Ser Tyr Asn Lys Leu 
65                  70                  75                  80  


Ser Glu Ile Asp Pro Ala Gly Phe Glu Asp Leu Pro Asn Leu Gln Glu 
                85                  90                  95      


Val Tyr Leu Asn Asn Asn Glu Leu Thr Ala Val Pro Ser Leu Gly Ala 
            100                 105                 110         


Ala Ser Ser His Val Val Ser Leu Phe Leu Gln His Asn Lys Ile Arg 
        115                 120                 125             


Ser Val Glu Gly Ser Gln Leu Lys Ala Tyr Leu Ser Leu Glu Val Leu 
    130                 135                 140                 


Asp Leu Ser Leu Asn Asn Ile Thr Glu Val Arg Asn Thr Cys Phe Pro 
145                 150                 155                 160 


His Gly Pro Pro Ile Lys Glu Leu Asn Leu Ala Gly Asn Arg Ile Gly 
                165                 170                 175     


Thr Leu Glu Leu Gly Ala Phe Asp Gly Leu Ser Arg Ser Leu Leu Thr 
            180                 185                 190         


Leu Arg Leu Ser Lys Asn Arg Ile Thr Gln Leu Pro Val Arg Ala Phe 
        195                 200                 205             


Lys Leu Pro Arg Leu Thr Gln Leu Asp Leu Asn Arg Asn Arg Ile Arg 
    210                 215                 220                 


Leu Ile Glu Gly Leu Thr Phe Gln Gly Leu Asn Ser Leu Glu Val Leu 
225                 230                 235                 240 


Lys Leu Gln Arg Asn Asn Ile Ser Lys Leu Thr Asp Gly Ala Phe Trp 
                245                 250                 255     


Gly Leu Ser Lys Met His Val Leu His Leu Glu Tyr Asn Ser Leu Val 
            260                 265                 270         


Glu Val Asn Ser Gly Ser Leu Tyr Gly Leu Thr Ala Leu His Gln Leu 
        275                 280                 285             


His Leu Ser Asn Asn Ser Ile Ala Arg Ile His Arg Lys Gly Trp Ser 
    290                 295                 300                 


Phe Cys Gln Lys Leu His Glu Leu Val Leu Ser Phe Asn Asn Leu Thr 
305                 310                 315                 320 


Arg Leu Asp Glu Glu Ser Leu Ala Glu Leu Ser Ser Leu Ser Val Leu 
                325                 330                 335     


Arg Leu Ser His Asn Ser Ile Ser His Ile Ala Glu Gly Ala Phe Lys 
            340                 345                 350         


Gly Leu Arg Ser Leu Arg Val Leu Asp Leu Asp His Asn Glu Ile Ser 
        355                 360                 365             


Gly Thr Ile Glu Asp Thr Ser Gly Ala Phe Ser Gly Leu Asp Ser Leu 
    370                 375                 380                 


Ser Lys Leu Thr Leu Phe Gly Asn Lys Ile Lys Ser Val Ala Lys Arg 
385                 390                 395                 400 


Ala Phe Ser Gly Leu Glu Gly Leu Glu His Leu Asn Leu Gly Gly Asn 
                405                 410                 415     


Ala Ile Arg Ser Val Gln Phe Asp Ala Phe Val Lys Met Lys Asn Leu 
            420                 425                 430         


Lys Glu Leu His Ile Ser Ser Asp Ser Phe Leu Cys Asp Cys Gln Leu 
        435                 440                 445             


Lys Trp Leu Pro Pro Trp Leu Ile Gly Arg Met Leu Gln Ala Phe Val 
    450                 455                 460                 


Thr Ala Thr Cys Ala His Pro Glu Ser Leu Lys Gly Gln Ser Ile Phe 
465                 470                 475                 480 


Ser Val Pro Pro Glu Ser Phe Val Cys Asp Asp Phe Leu Lys Pro Gln 
                485                 490                 495     


Ile Ile Thr Gln Pro Glu Thr Thr Met Ala Met Val Gly Lys Asp Ile 
            500                 505                 510         


Arg Phe Thr Cys Ser Ala Ala Ser Ser Ser Ser Ser Pro Met Thr Phe 
        515                 520                 525             


Ala Trp Lys Lys Asp Asn Glu Val Leu Thr Asn Ala Asp Met Glu Asn 
    530                 535                 540                 


Phe Val His Val His Ala Gln Asp Gly Glu Val Met Glu Tyr Thr Thr 
545                 550                 555                 560 


Ile Leu His Leu Arg Gln Val Thr Phe Gly His Glu Gly Arg Tyr Gln 
                565                 570                 575     


Cys Val Ile Thr Asn His Phe Gly Ser Thr Tyr Ser His Lys Ala Arg 
            580                 585                 590         


Leu Thr Val Asn Val Leu Pro Ser Phe Thr Lys Thr Pro His Asp Ile 
        595                 600                 605             


Thr Ile Arg Thr Thr Thr Met Ala Arg Leu Glu Cys Ala Ala Thr Gly 
    610                 615                 620                 


His Pro Asn Pro Gln Ile Ala Trp Gln Lys Asp Gly Gly Thr Asp Phe 
625                 630                 635                 640 


Pro Ala Ala Arg Glu Arg Arg Met His Val Met Pro Asp Asp Asp Val 
                645                 650                 655     


Phe Phe Ile Thr Asp Val Lys Ile Asp Asp Ala Gly Val Tyr Ser Cys 
            660                 665                 670         


Thr Ala Gln Asn Ser Ala Gly Ser Ile Ser Ala Asn Ala Thr Leu Thr 
        675                 680                 685             


Val Leu Glu Thr Pro Ser Leu Val Val Pro Leu Glu Asp Arg Val Val 
    690                 695                 700                 


Ser Val Gly Glu Thr Val Ala Leu Gln Cys Lys Ala Thr Gly Asn Pro 
705                 710                 715                 720 


Pro Pro Arg Ile Thr Trp Phe Lys Gly Asp Arg Pro Leu Ser Leu Thr 
                725                 730                 735     


Glu Arg His His Leu Thr Pro Asp Asn Gln Leu Leu Val Val Gln Asn 
            740                 745                 750         


Val Val Ala Glu Asp Ala Gly Arg Tyr Thr Cys Glu Met Ser Asn Thr 
        755                 760                 765             


Leu Gly Thr Glu Arg Ala His Ser Gln Leu Ser Val Leu Pro Ala Ala 
    770                 775                 780                 


Gly Cys Arg Lys Asp Gly Thr Thr Val Gly Ile Phe Thr Ile Ala Val 
785                 790                 795                 800 


Val Ser Ser Ile Val Leu Thr Ser Leu Val Trp Val Cys Ile Ile Tyr 
                805                 810                 815     


Gln Thr Arg Lys Lys Ser Glu Glu Tyr Ser Val Thr Asn Thr Asp Glu 
            820                 825                 830         


Thr Val Val Pro Pro Asp Val Pro Ser Tyr Leu Ser Ser Gln Gly Thr 
        835                 840                 845             


Leu Ser Asp Arg Gln Glu Thr Val Val Arg Thr Glu Gly Gly Pro Gln 
    850                 855                 860                 


Ala Asn Gly His Ile Glu Ser Asn Gly Val Cys Pro Arg Asp Ala Ser 
865                 870                 875                 880 


His Phe Pro Glu Pro Asp Thr His Ser Val Ala Cys Arg Gln Pro Lys 
                885                 890                 895     


Leu Cys Ala Gly Ser Ala Tyr His Lys Glu Pro Trp Lys Ala Met Glu 
            900                 905                 910         


Lys Ala Glu Gly Thr Pro Gly Pro His Lys Met Glu His Gly Gly Arg 
        915                 920                 925             


Val Val Cys Ser Asp Cys Asn Thr Glu Val Asp Cys Tyr Ser Arg Gly 
    930                 935                 940                 


Gln Ala Phe His Pro Gln Pro Val Ser Arg Asp Ser Ala Gln Pro Ser 
945                 950                 955                 960 


Ala Pro Asn Gly Pro Glu Pro Gly Gly Ser Asp Gln Glu His Ser Pro 
                965                 970                 975     


His His Gln Cys Ser Arg Thr Ala Ala Gly Ser Cys Pro Glu Cys Gln 
            980                 985                 990         


Gly Ser Leu Tyr Pro Ser Asn His  Asp Arg Met Leu Thr  Ala Val Lys 
        995                 1000                 1005             


Lys Lys  Pro Met Ala Ser Leu  Asp Gly Lys Gly Asp  Ser Ser Trp 
    1010                 1015                 1020             


Thr Leu  Ala Arg Leu Tyr His  Pro Asp Ser Thr Glu  Leu Gln Pro 
    1025                 1030                 1035             


Ala Ser  Ser Leu Thr Ser Gly  Ser Pro Glu Arg Ala  Glu Ala Gln 
    1040                 1045                 1050             


Tyr Leu  Leu Val Ser Asn Gly  His Leu Pro Lys Ala  Cys Asp Ala 
    1055                 1060                 1065             


Ser Pro  Glu Ser Thr Pro Leu  Thr Gly Gln Leu Pro  Gly Lys Gln 
    1070                 1075                 1080             


Arg Val  Pro Leu Leu Leu Ala  Pro Lys Ser 
    1085                 1090             


<210>  3
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210>  4
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala Pro 
    370                 375                 380                 


Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
385                 390                 395         


<210>  5
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Met Trp Asn Ile Leu Lys Pro Arg Thr His Leu Leu Cys Met 
1               5                   10                  15      


Thr Asn Met Phe Cys Thr Arg His Glu Gly Thr Asp Ser Thr Val Phe 
            20                  25                  30          


Leu Pro His Ser His Asn Ile Ser Glu Trp Ile Ser Arg Arg Val Ser 
        35                  40                  45              


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
    50                  55                  60                  


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
65                  70                  75                  80  


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
                85                  90                  95      


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
            100                 105                 110         


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
        115                 120                 125             


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
    130                 135                 140                 


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
145                 150                 155                 160 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
                165                 170                 175     


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
            180                 185                 190         


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
        195                 200                 205             


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
    210                 215                 220                 


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
225                 230                 235                 240 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
                245                 250                 255     


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
            260                 265                 270         


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
        275                 280                 285             


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
    290                 295                 300                 


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
305                 310                 315                 320 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
                325                 330                 335     


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
            340                 345                 350 


<210>  6
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Glu Gly Pro Trp Pro His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Trp Pro Gly Thr Val Val Ser Glu Gly Gln His Val Thr Leu Gln 
        35                  40                  45              


Cys Arg Ser Arg Leu Gly Phe Asn Glu Phe Ser Leu Ser Lys Glu Asp 
    50                  55                  60                  


Gly Met Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Arg Asn Ser Phe 
65                  70                  75                  80  


Leu Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Cys 
                85                  90                  95      


Ser Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Val His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Val Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Arg Phe Glu Arg Phe Leu Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Thr Glu Asp Pro Leu Arg Leu Val Gly Gln Leu His Asp Ala Gly Ser 
                165                 170                 175     


Gln Val Asn Tyr Ser Met Gly Pro Met Thr Pro Ala Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Val Thr His Leu Pro Tyr Glu Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Val Val Gly Leu Tyr Gly Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Arg Ser Leu Phe Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Ala Glu Ala Gly Glu Leu Arg Leu Thr Ala Val Leu Arg Val 
            260                 265                 270         


Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Val Thr His Gly 
        275                 280                 285             


Gly Asn Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro His Ala Trp 
    290                 295                 300                 


Ser Asp Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Ser Arg 
305                 310                 315                 320 


His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Pro Phe Ala 
                325                 330                 335     


Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ala Asn Lys Lys Asn 
            340                 345                 350         


Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn Arg 
        355                 360                 365             


Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
    370                 375                 380                 


Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg 
385                 390                 395                 400 


Pro Lys Thr Pro Pro Thr Asp Thr Ser Val 
                405                 410 


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

His His His His His 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

His His His His His His 
1               5       


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Arg Tyr Ile Arg Ser 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Phe His His Thr 
1               


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


