
                                SEQUENCE LISTING

<110> Icahn School of Medicine at Mount Sinai

<120> Small Molecule Transcription Modulators
  of Bromodomains

<130> 27527-0100WO1

<150> 62/005,645          
<151> 2014-05-30  

<160> 38

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 1
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu
 1               5                  10                  15      
Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val
            20                  25                  30          
Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn
        35                  40                  45              
Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr
    50                  55                  60                  
Gln Glu Pro Trp Gln Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn
65                  70                  75                  80  
Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser
                85                  90                  95      
Lys Leu Ala Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser
            100                 105                 110         
Leu Gly
        


<210> 2
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 2
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu
 1               5                  10                  15      
Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val
            20                  25                  30          
Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser
        35                  40                  45              
Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr
    50                  55                  60                  
Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn
65                  70                  75                  80  
Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser
                85                  90                  95      
Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser
            100                 105                 110         
Leu Gly
        


<210> 3
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 3
Gly Arg Val Thr Asn Gln Leu Gln Tyr Leu His Lys Val Val Met Lys
 1               5                  10                  15      
Ala Leu Trp Lys His Gln Phe Ala Trp Pro Phe Arg Gln Pro Val Asp
            20                  25                  30          
Ala Val Lys Leu Gly Leu Pro Asp Tyr His Lys Ile Ile Lys Gln Pro
        35                  40                  45              
Met Asp Met Gly Thr Ile Lys Arg Arg Leu Glu Asn Asn Tyr Tyr Trp
    50                  55                  60                  
Ala Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys
65                  70                  75                  80  
Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Thr
                85                  90                  95      
Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Ser Met Pro Gln Glu Glu
            100                 105                 110         
Gln
    


<210> 4
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 4
Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys
 1               5                  10                  15      
Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp
            20                  25                  30          
Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro
        35                  40                  45              
Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp
    50                  55                  60                  
Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys
65                  70                  75                  80  
Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala
                85                  90                  95      
Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu
            100                 105                 110         
Val
    


<210> 5
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 5
Lys Arg Gln Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val Val Leu Lys
 1               5                  10                  15      
Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp
            20                  25                  30          
Ala Val Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro
        35                  40                  45              
Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp
    50                  55                  60                  
Asn Ala Gln Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys
65                  70                  75                  80  
Tyr Ile Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Glu Ala
                85                  90                  95      
Leu Glu Lys Leu Phe Leu Gln Lys Ile Asn Glu Leu Pro Thr Glu Glu
            100                 105                 110         
Thr
    


<210> 6
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 6
Gly Arg Leu Thr Asn Gln Leu Gln Tyr Leu Gln Lys Val Val Leu Lys
 1               5                  10                  15      
Asp Leu Trp Lys His Ser Phe Ser Trp Pro Phe Gln Arg Pro Val Asp
            20                  25                  30          
Ala Val Lys Leu Gln Leu Pro Asp Tyr Tyr Thr Ile Ile Lys Asn Pro
        35                  40                  45              
Met Asp Leu Asn Thr Ile Lys Lys Arg Leu Glu Asn Lys Tyr Tyr Ala
    50                  55                  60                  
Lys Ala Ser Glu Cys Ile Glu Asp Phe Asn Thr Met Phe Ser Asn Cys
65                  70                  75                  80  
Tyr Leu Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Gln Ala
                85                  90                  95      
Leu Glu Lys Leu Phe Met Gln Lys Leu Ser Gln Met Pro Gln Glu Glu
            100                 105                 110         
Gln
    


<210> 7
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 7
Gly Lys Leu Ser Glu Gln Leu Lys His Cys Asn Gly Ile Leu Lys Glu
 1               5                  10                  15      
Leu Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro
            20                  25                  30          
Val Asp Ala Ser Ala Leu Gly Leu His Asp Tyr His Asp Ile Ile Lys
        35                  40                  45              
His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Glu Asn Arg Asp
    50                  55                  60                  
Tyr Arg Asp Ala Gln Glu Phe Ala Ala Asp Val Arg Leu Met Phe Ser
65                  70                  75                  80  
Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Asp Val Val Ala Met Ala
                85                  90                  95      
Arg Lys Leu Gln Asp Val Phe Glu Phe Arg Tyr Ala Lys Met Pro Asp
            100                 105                 110         
Glu Pro Leu
        115 


<210> 8
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 8
Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg Glu
 1               5                  10                  15      
Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro
            20                  25                  30          
Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile Lys
        35                  40                  45              
His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg Glu
    50                  55                  60                  
Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe Ser
65                  70                  75                  80  
Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala
                85                  90                  95      
Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp
            100                 105                 110         
Glu Pro Val
        115 


<210> 9
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 9
Ser Lys Val Ser Glu Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu
 1               5                  10                  15      
Met Phe Ala Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro
            20                  25                  30          
Val Asp Val Glu Ala Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys
        35                  40                  45              
His Pro Met Asp Met Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu
    50                  55                  60                  
Tyr Arg Asp Ala Gln Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser
65                  70                  75                  80  
Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met Ala
                85                  90                  95      
Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp
            100                 105                 110         
Glu Pro Glu
        115 


<210> 10
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 10
Thr Phe Arg Glu Leu Arg Ile Phe Leu Arg Asn Val Thr His Arg Leu
 1               5                  10                  15      
Ala Ile Asp Lys Arg Phe Arg Val Phe Thr Lys Pro Val Asp Pro Asp
            20                  25                  30          
Glu Val Pro Asp Tyr Val Thr Val Ile Lys Gln Pro Met Asp Leu Ser
        35                  40                  45              
Ser Val Ile Ser Lys Ile Asp Leu His Lys Tyr Leu Thr Val Lys Asp
    50                  55                  60                  
Tyr Leu Arg Asp Ile Asp Leu Ile Cys Ser Asn Ala Leu Glu Tyr Asn
65                  70                  75                  80  
Pro Asp Arg Asp Pro Gly Asp Arg Leu Ile Arg His Arg Ala Cys Ala
                85                  90                  95      
Leu Arg Asp Thr Ala Tyr Ala Ile Ile Lys Glu Glu Leu Asp Glu Asp
            100                 105                 110         
Phe
    


<210> 11
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 11
Asn Thr Leu Arg Glu Leu Arg Leu Phe Leu Arg Asp Val Thr Lys Arg
 1               5                  10                  15      
Leu Ala Thr Asp Lys Arg Phe Asn Ile Phe Ser Lys Pro Val Ser Val
            20                  25                  30          
Asp Ile Glu Glu Asp Tyr Leu Glu Val Ile Lys Glu Pro Met Asp Leu
        35                  40                  45              
Ser Thr Val Ile Thr Lys Ile Asp Lys His Asn Tyr Leu Thr Ala Lys
    50                  55                  60                  
Asp Phe Leu Lys Asp Ile Asp Leu Ile Cys Ser Asn Ala Leu Glu Tyr
65                  70                  75                  80  
Asn Pro Asp Lys Asp Pro Gly Asp Lys Ile Ile Arg His Arg Ala Cys
                85                  90                  95      
Thr Leu Lys Asp Thr Ala His Ala Ile Ile Ala Ala Glu Leu Asp Pro
            100                 105                 110         
Glu Phe
        


<210> 12
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 12
Val Glu Gln Thr Pro Leu Gln Glu Ala Leu Asn Gln Leu Met Arg Gln
 1               5                  10                  15      
Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val Thr Asp
            20                  25                  30          
Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe
        35                  40                  45              
Ser Thr Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser Ile Glu
    50                  55                  60                  
Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Thr Asn Ala Met Ile Tyr
65                  70                  75                  80  
Asn Lys Pro Glu Thr Ile Tyr Tyr Lys Ala Ala Lys Lys Leu Leu His
                85                  90                  95      
Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu
            100                 105                 110 


<210> 13
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 13
Asn Glu Ser Thr Pro Ile Gln Gln Leu Leu Glu His Phe Leu Arg Gln
 1               5                  10                  15      
Leu Gln Arg Lys Asp Pro His Gly Phe Phe Ala Phe Pro Val Thr Asp
            20                  25                  30          
Ala Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe
        35                  40                  45              
Gly Thr Met Lys Asp Lys Ile Val Ala Asn Glu Tyr Lys Ser Val Thr
    50                  55                  60                  
Glu Phe Lys Ala Asp Phe Lys Leu Met Cys Asp Asn Ala Met Thr Tyr
65                  70                  75                  80  
Asn Arg Pro Asp Thr Val Tyr Tyr Lys Leu Ala Lys Lys Ile Leu His
                85                  90                  95      
Ala Gly Phe Lys Met Met Ser Lys Glu Arg Leu Leu Ala Leu
            100                 105                 110 


<210> 14
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 14
Met Gln Leu Thr Pro Phe Leu Ile Leu Leu Arg Lys Thr Leu Glu Gln
 1               5                  10                  15      
Leu Gln Glu Lys Asp Thr Gly Asn Ile Phe Ser Glu Pro Val Pro Leu
            20                  25                  30          
Ser Glu Val Pro Asp Tyr Leu Asp His Ile Lys Lys Pro Met Asp Phe
        35                  40                  45              
Phe Thr Met Lys Gln Asn Leu Glu Ala Tyr Arg Tyr Leu Asn Phe Asp
    50                  55                  60                  
Asp Phe Glu Glu Asp Phe Asn Leu Ile Val Ser Asn Cys Leu Lys Tyr
65                  70                  75                  80  
Asn Ala Lys Asp Thr Ile Phe Tyr Arg Ala Ala Val Arg Leu Arg Glu
                85                  90                  95      
Gln Gly Gly Ala Val Leu Arg Gln Ala Arg Arg Gln Ala Glu
            100                 105                 110 


<210> 15
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 15
Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe
 1               5                  10                  15      
Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu
            20                  25                  30          
Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser
        35                  40                  45              
Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro
    50                  55                  60                  
Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu
65                  70                  75                  80  
Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu
                85                  90                  95      
Asn Tyr Phe Glu Glu Leu Leu Lys Asn Leu Tyr Pro Glu Lys Arg
            100                 105                 110     


<210> 16
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 16
Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys Glu Arg Val Leu Leu Ala
 1               5                  10                  15      
Leu Phe Cys His Glu Pro Cys Arg Pro Leu His Gln Leu Ala Thr Asp
            20                  25                  30          
Ser Thr Phe Ser Leu Asp Gln Pro Gly Gly Thr Leu Asp Leu Thr Leu
        35                  40                  45              
Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser Pro Pro Tyr Ser Ser Pro
    50                  55                  60                  
Gln Glu Phe Ala Gln Asp Val Gly Arg Met Phe Lys Gln Phe Asn Lys
65                  70                  75                  80  
Leu Thr Glu Asp Lys Ala Asp Val Gln Ser Ile Ile Gly Leu Gln Arg
                85                  90                  95      
Phe Phe Glu Thr Arg Met Asn Glu Ala Phe Gly Asp Thr Lys
            100                 105                 110 


<210> 17
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 17
Arg Asp Asp Ser Lys Asp Leu Ala Leu Cys Ser Met Ile Leu Thr Glu
 1               5                  10                  15      
Met Glu Thr His Glu Asp Ala Trp Pro Phe Leu Leu Pro Val Asn Leu
            20                  25                  30          
Lys Leu Val Pro Gly Tyr Lys Lys Val Ile Lys Lys Pro Met Asp Phe
        35                  40                  45              
Ser Thr Ile Arg Glu Lys Leu Ser Ser Gly Gln Tyr Pro Asn Leu Glu
    50                  55                  60                  
Thr Phe Ala Leu Asp Val Arg Leu Val Phe Asp Asn Cys Glu Thr Phe
65                  70                  75                  80  
Asn Glu Asp Asp Ser Asp Ile Gly Arg Ala Gly His Asn Met Arg Lys
                85                  90                  95      
Tyr Phe Glu Lys Lys Trp Thr Asp Thr Phe Lys Val Ser
            100                 105                 


<210> 18
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 18
Lys Asp Pro Asp Gln Leu Tyr Thr Thr Leu Lys Asn Leu Leu Ala Gln
 1               5                  10                  15      
Ile Lys Ser His Pro Ser Ala Trp Pro Phe Met Glu Pro Val Lys Lys
            20                  25                  30          
Ser Glu Ala Pro Asp Tyr Tyr Glu Val Ile Arg Phe Pro Ile Asp Leu
        35                  40                  45              
Lys Thr Met Thr Glu Arg Leu Arg Ser Arg Tyr Tyr Val Thr Arg Lys
    50                  55                  60                  
Leu Phe Val Ala Asp Leu Gln Arg Val Ile Ala Asn Cys Arg Glu Tyr
65                  70                  75                  80  
Asn Pro Pro Asp Ser Glu Tyr Cys Arg Cys Ala Ser Ala Leu Glu Lys
                85                  90                  95      
Phe Phe Tyr Phe Lys Leu Lys Glu Gly Gly Leu Ile Asp Lys
            100                 105                 110 


<210> 19
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 19
Arg Asp Pro Asp Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu Gln Gln
 1               5                  10                  15      
Val Lys Ser His Gln Ser Ala Trp Pro Phe Met Glu Pro Val Lys Arg
            20                  25                  30          
Thr Glu Ala Pro Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met Asp Leu
        35                  40                  45              
Lys Thr Met Ser Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser Lys Lys
    50                  55                  60                  
Leu Phe Met Ala Asp Leu Gln Arg Val Phe Thr Asn Cys Lys Glu Tyr
65                  70                  75                  80  
Asn Pro Pro Glu Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu Glu Lys
                85                  90                  95      
Phe Phe Phe Ser Lys Ile Lys Glu Ala Gly Leu Ile Asp Lys
            100                 105                 110 


<210> 20
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 20
Pro Leu Thr Glu Lys Asp Tyr Glu Gly Leu Lys Arg Val Leu Arg Ser
 1               5                  10                  15      
Leu Gln Ala His Lys Met Ala Trp Pro Phe Leu Glu Pro Val Asp Pro
            20                  25                  30          
Asn Asp Ala Pro Asp Tyr Tyr Gly Val Ile Lys Glu Pro Met Asp Leu
        35                  40                  45              
Ala Thr Met Glu Glu Arg Val Gln Arg Arg Tyr Tyr Glu Lys Leu Thr
    50                  55                  60                  
Glu Phe Val Ala Asp Met Thr Lys Ile Phe Asp Asn Cys Arg Tyr Tyr
65                  70                  75                  80  
Asn Pro Ser Asp Ser Pro Phe Tyr Gln Cys Ala Glu Val Leu Glu Ser
                85                  90                  95      
Phe Phe Val Gln Lys Leu Lys Gly Phe Lys Ala Ser Arg Ser
            100                 105                 110 


<210> 21
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 21
Asp Asp Gln Val Ala Phe Ser Phe Ile Leu Asp Asn Ile Val Thr Gln
 1               5                  10                  15      
Lys Met Met Ala Val Pro Asp Ser Trp Pro Phe His His Pro Val Asn
            20                  25                  30          
Lys Lys Phe Val Pro Asp Tyr Tyr Lys Val Ile Val Asn Pro Met Asp
        35                  40                  45              
Leu Glu Thr Ile Arg Lys Asn Ile Ser Lys His Lys Tyr Gln Ser Arg
    50                  55                  60                  
Glu Ser Phe Leu Asp Asp Val Asn Leu Ile Leu Ala Asn Ser Val Lys
65                  70                  75                  80  
Tyr Asn Gly Pro Glu Ser Gln Tyr Thr Lys Thr Ala Gln Glu Ile Val
                85                  90                  95      
Asn Val Cys Tyr Gln Thr Leu Thr Glu Tyr Asp Glu His Leu Thr
            100                 105                 110     


<210> 22
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 22
Asp Asp Gln Val Ala Phe Ser Phe Ile Leu Asp Asn Ile Val Thr Gln
 1               5                  10                  15      
Lys Met Met Ala Val Pro Asp Ser Trp Pro Phe His His Pro Val Asn
            20                  25                  30          
Lys Lys Phe Val Pro Asp Tyr Tyr Lys Met Ile Val Asn Pro Val Asp
        35                  40                  45              
Leu Glu Thr Ile Arg Lys Asn Ile Ser Lys His Lys Tyr Gln Ser Arg
    50                  55                  60                  
Glu Ser Phe Leu Asp Asp Val Asn Leu Ile Leu Ala Asn Ser Val Lys
65                  70                  75                  80  
Tyr Asn Gly Pro Glu Ser Gln Tyr Thr Lys Thr Ala Gln Glu Ile Val
                85                  90                  95      
Asn Ile Cys Tyr Gln Thr Ile Thr Glu Tyr Asp Glu His Leu Thr
            100                 105                 110     


<210> 23
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 23
Asp Pro Met Val Thr Leu Ser Ser Ile Leu Glu Ser Ile Ile Asn Asp
 1               5                  10                  15      
Met Arg Asp Leu Pro Asn Thr Tyr Pro Phe His Thr Pro Val Asn Ala
            20                  25                  30          
Lys Val Val Lys Asp Tyr Tyr Lys Ile Ile Thr Arg Pro Met Asp Leu
        35                  40                  45              
Gln Thr Leu Arg Glu Asn Val Arg Lys Arg Leu Tyr Pro Ser Arg Glu
    50                  55                  60                  
Glu Phe Arg Glu His Leu Glu Leu Ile Val Lys Asn Ser Ala Thr Tyr
65                  70                  75                  80  
Asn Gly Pro Lys His Ser Leu Thr Gln Ile Ser Gln Ser Met Leu Asp
                85                  90                  95      
Leu Cys Asp Glu Lys Leu Lys Glu Lys Glu Asp Lys Leu Ala
            100                 105                 110 


<210> 24
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 24
Asn Leu Thr Lys Lys Met Lys Lys Ile Val Asp Ala Val Ile Lys Tyr
 1               5                  10                  15      
Lys Asp Ser Ser Ser Gly Arg Gln Leu Ser Glu Val Phe Ile Gln Leu
            20                  25                  30          
Pro Ser Arg Lys Glu Leu Pro Glu Tyr Tyr Glu Leu Ile Arg Lys Pro
        35                  40                  45              
Val Asp Phe Lys Lys Ile Lys Glu Arg Ile Arg Asn His Lys Tyr Arg
    50                  55                  60                  
Ser Leu Asn Asp Leu Glu Lys Asp Val Met Leu Leu Cys Gln Asn Ala
65                  70                  75                  80  
Gln Thr Phe Asn Leu Glu Gly Ser Leu Ile Tyr Glu Asp Ser Ile Val
                85                  90                  95      
Leu Gln Ser Val Phe Thr Ser Val Arg Gln Lys Ile Glu Lys Glu Asp
            100                 105                 110         
Asp
    


<210> 25
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 25
Lys Leu Thr Lys Gln Met Asn Ala Ile Ile Asp Thr Val Ile Asn Tyr
 1               5                  10                  15      
Lys Asp Arg Gln Leu Ser Glu Val Phe Ile Gln Leu Pro Ser Arg Lys
            20                  25                  30          
Glu Leu Pro Glu Tyr Tyr Glu Leu Ile Arg Lys Pro Val Asp Phe Lys
        35                  40                  45              
Lys Ile Lys Glu Arg Ile Arg Asn His Lys Tyr Arg Ser Leu Gly Asp
    50                  55                  60                  
Leu Glu Lys Asp Val Met Leu Leu Cys His Asn Ala Gln Thr Phe Asn
65                  70                  75                  80  
Leu Glu Gly Ser Gln Ile Tyr Glu Asp Ser Ile Val Leu Gln Ser Val
                85                  90                  95      
Phe Lys Ser Ala Arg Gln Lys Ile Ala Lys Glu Glu Glu
            100                 105                 


<210> 26
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 26
Pro Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val Lys Asn Tyr
 1               5                  10                  15      
Thr Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu Arg Leu Pro
            20                  25                  30          
Ser Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys Lys Pro Met
        35                  40                  45              
Asp Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys Tyr Gln Asp
    50                  55                  60                  
Ile Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn Asn Ala Cys
65                  70                  75                  80  
Thr Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala Leu Val Leu
                85                  90                  95      
His Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly Asp Glu Asp
            100                 105                 110         


<210> 27
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 27
Tyr Leu Lys Glu Ile Leu Glu Gln Leu Leu Glu Ala Ile Val Val Ala
 1               5                  10                  15      
Thr Asn Pro Ser Gly Arg Leu Ile Ser Glu Leu Phe Gln Lys Leu Pro
            20                  25                  30          
Ser Lys Val Gln Tyr Pro Asp Tyr Tyr Ala Ile Ile Lys Glu Pro Ile
        35                  40                  45              
Asp Leu Lys Thr Ile Ala Gln Arg Ile Gln Asn Gly Ser Tyr Lys Ser
    50                  55                  60                  
Ile His Ala Met Ala Lys Asp Ile Asp Leu Leu Ala Lys Asn Ala Lys
65                  70                  75                  80  
Thr Tyr Asn Glu Pro Gly Ser Gln Val Phe Lys Asp Ala Asn Ser Ile
                85                  90                  95      
Lys Lys Ile Phe Tyr Met Lys Lys Ala Glu Ile Glu His His Glu Met
            100                 105                 110         


<210> 28
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 28
Asp Pro Ile Ala Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr
 1               5                  10                  15      
Lys Asp Glu Gln Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro
            20                  25                  30          
Lys Arg Arg Asn Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile
        35                  40                  45              
Asp Leu Met Lys Ile Gln Gln Lys Leu Lys Met Glu Asp Tyr Asp Asp
    50                  55                  60                  
Val Asn Leu Leu Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys
65                  70                  75                  80  
Ser Tyr Tyr Lys Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu
                85                  90                  95      
Trp Asp Leu Tyr Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu
            100                 105                 110         


<210> 29
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 29
Asp Val Ser Asn Pro Phe Tyr Gln Leu Tyr Asp Thr Val Arg Ser Cys
 1               5                  10                  15      
Arg Asn Asn Gln Gly Gln Leu Ile Ala Glu Pro Phe Tyr His Leu Pro
            20                  25                  30          
Ser Lys Lys Lys Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile
        35                  40                  45              
Ser Leu Gln Gln Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr
    50                  55                  60                  
Leu Asp His Leu Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys
65                  70                  75                  80  
Arg Tyr Asn Val Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu
                85                  90                  95      
Gln Gln Val Met Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp
            100                 105                 110         


<210> 30
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic peptide

<400> 30
Asn Val Thr Leu Leu Ile Gln Glu Leu Ile His Asn Leu Phe Val Ser
 1               5                  10                  15      
Val Met Ser His Gln Asp Asp Glu Gly Arg Cys Tyr Ser Asp Ser Leu
            20                  25                  30          
Ala Glu Ile Pro Ala Val Asp Pro Asn Phe Pro Asn Lys Pro Pro Leu
        35                  40                  45              
Thr Phe Asp Ile Ile Arg Lys Asn Val Glu Asn Asn Arg Tyr Arg Arg
    50                  55                  60                  
Leu Asp Leu Phe Gln Glu His Met Phe Glu Val Leu Glu Arg Ala Arg
65                  70                  75                  80  
Arg Met Asn Arg Thr Asp Ser Glu Ile Tyr Glu Asp Ala Val Glu Leu
                85                  90                  95      
Gln Gln Phe Phe Ile Lys Ile Arg Asp Glu Leu Cys Lys Asn Gly Glu
            100                 105                 110         


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 31
gagggacaga agaacccaca                                             20

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 32
cagttctcga cccttgcttc                                             20

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 33
agacagccgc atcttcttgt                                             20

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 34
cttgccgtgg gtagagtcat                                             20

<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 35
agctcaccgg gctcaaggct                                             20

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 36
agcagcagct ggtcgtgctc                                             20

<210> 37
<211> 20
<212> DNA
<213> uenArtificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 37
cggagggtca gattttgaat                                             20

<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 38
gcccgtagca cttttgtttc                                             20
