                         SEQUENCE LISTING

<110>  4-Antibody AG
       Ludwig Institute for Cancer Research Ltd.
       Memorial Sloan-Kettering Cancer Center
       Gonzalez, Ana M
       Underwood, Dennis J
       Wilson, Nicholas S
       Zappasodi, Roberta
       Wolchok, Jedd David
       Merghoub, Taha
       Leger, Olivier
       Seibert, Volker
       van Dijk, Marc
       Schaer, David
       Ritter, Gerd
       Tsuji, Takemasa
 
<120>  ANTI-GITR ANTIBODIES AND METHODS OF USE THEREOF

<130>  3617.009TW02/EKS/CLD

<140>  To Be Assigned
<141>  Herewith

<150>  62/004,071
<151>  2014-05-28

<150>  62/161,250
<151>  2015-05-13

<160>  1118  

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 library consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be Aspartic Acid, Glutamic Acid, Glycine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Alanine, Valine, Leucine, Isoleucine, Proline, 
       Phenylalanine, Methionine, or Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be Tyrosine, Glycine, Asparagine, Glutamine, Serine, 
       Threonine, Cysteine, Tryptophan, Phenylalanine, or Histidine

<400>  1

Xaa Tyr Xaa Met Xaa 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 library consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be Valine, Alanine, Leucine, Isoleucine, Proline, 
       Phenylalanine, Methionine, or Threonine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Arginine, Lysine, Histidine, Glutamine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  can be Threonine, Glycine, Asparagine, Glutamine, Serine, 
       Cysteine, Tryptophan, Tyrosine, Valine, Isoleucine or Proline

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be Tyrosine, Glycine, Asparagine, Glutamine, Serine, 
       Threonine, Cysteine, Tryptophan, Phenylalanine, Histidine or 
       Alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  can be Aspartic Acid, Glutamic Acid, Glycine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  can be Valine, Alanine, Leucine, Isoleucine, Proline, 
       Phenylalanine, Methionine, Threonine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  can be Threonine, Glycine, Asparagine, Glutamine, Serine, 
       Cysteine, Tryptophan, Tyrosine, Valine, Isoleucine, Proline, or 
       Alanine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  can be Asparagine, Glycine, Glutamine, Serine, Threonine, 
       Cysteine, Tryptophan, Tyrosine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  can be Lysine, Arginine, Histidine, Glutamine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  can be Aspartic Acid, Glutamic Acid, Glycine, or Alanine

<400>  2

Xaa Ile Xaa Xaa Xaa Ser Gly Xaa Xaa Xaa Tyr Xaa Gln Lys Phe Xaa 
1               5                   10                  15      


Xaa 
    


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 library consensus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  can be Phenylalanine, Alanine, Valine, Leucine, Isoleucine, 
       Proline, Methionine, Tyrosine, Tryptophan, Histidine or Serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  can be Alanine or Aspartic Acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  can be Tyrosine, Glycine, Asparagine, Glutamine, Serine, 
       Threonine, Cysteine, Tryptophan, Phenylalanine, Histidine, or 
       Valine

<400>  3

Ser Gly Thr Val Arg Gly Xaa Xaa Xaa 
1               5                   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 library consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  can be Leucine, Alanine, Valine, Isoleucine, Proline, 
       Phenylalanine or Methionine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  can be Leucine, Alanine, Valine, Isoleucine, Proline, 
       Phenylalanine, Methionine, or Serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  can be Asparagine, Glycine, Glutamine, Serine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  can be Serine, Glycine, Asparagine, Glutamine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  can be Glycine, Asparagine, Glutamine, Serine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  can be Asparagine, Glycine, Glutamine, Serine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  can be Glutamine, Glycine, Asparagine, Serine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  can be Asparagine, Glycine, Glutamine, Serine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  can be Threonine, Glycine, Asparagine, Glutamine, Serine, 
       Cysteine, Tryptophan, Tyrosine, Valine, Isoleucine or Alanine

<400>  4

Lys Ser Ser Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Tyr Leu 
1               5                   10                  15      


Xaa 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 library consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be Tryptophan, Glycine, Asparagine, Glutamine, Serine, 
       Threonine, Cysteine, Tyrosine, Phenylalanine, Histidine, or 
       Alanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  can be Glutamic Acid, Aspartic Acid, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  can be Serine, Glycine, Asparagine, Glutamine, Threonine, 
       Cysteine, Tryptophan, Tyrosine or Alanine

<400>  5

Xaa Ala Ser Thr Arg Xaa Xaa 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 library consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can be Asparagine, Glycine, Glutamine, Serine, Threonine, 
       Cysteine, Tryptophan, or Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Aspartic Acid, Glutamic Acid, or Tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be Serine, Glycine, Asparagine, Glutamine, Threonine, 
       Cysteine, Tryptophan, Tyrosine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  can be Tyrosine, Glycine, Asparagine, Glutamine, Serine, 
       Threonine, Cysteine, Tryptophan, Phenylalanine, Histidine, 
       Leucine, or Alanaine

<400>  6

Gln Xaa Xaa Tyr Xaa Xaa Pro Tyr Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 library consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be Aspartic Acid, Glutamic Acid, or Glycine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Alanine or Valine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be Tyrosine or Histidine

<400>  7

Xaa Tyr Xaa Met Xaa 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 library consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be Valine or Leucine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Arginine, Lysine, or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be Tyrosine or Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  can be Aspartic Acid, Glutamic Acid, or Glycine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  can be Valine or Leucine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  can be Threonine or Serine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  can be Lysine, Arginine, or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  can be Aspartic Acid, Glutamic Acid, or Glycine

<400>  8

Xaa Ile Xaa Thr Xaa Ser Gly Xaa Xaa Xaa Tyr Asn Gln Lys Phe Xaa 
1               5                   10                  15      


Xaa 
    


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 library consensus

<400>  9

Ser Gly Thr Val Arg Gly Phe Ala Tyr 
1               5                   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 library consensus


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  can be Glycine or Serine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  can be Threonine or Serine

<400>  10

Lys Ser Ser Gln Ser Leu Leu Asn Ser Xaa Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Xaa 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 library consensus

<400>  11

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 library consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  can be Tyrosine, Phenylalanine or Serine

<400>  12

Gln Asn Xaa Tyr Ser Xaa Pro Tyr Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  13

Asp Tyr Ala Met Tyr 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  14

Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  15

Ser Gly Thr Val Arg Gly Phe Ala Tyr 
1               5                   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  16

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  17

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  18

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 from GL variants

<400>  19

Gly Tyr Ala Met Tyr 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 from GL variants

<400>  20

Gly Tyr Ala Met His 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 from GL variants

<400>  21

Asp Tyr Ala Met Tyr 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 from GL variants

<400>  22

Glu Tyr Ala Met His 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 from GL variants

<400>  23

Glu Tyr Ala Met Tyr 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  24

Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  25

Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  26

Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  27

Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  28

Val Ile Arg Thr Phe Ser Gly Asp Leu Thr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  29

Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  30

Val Ile Arg Thr Tyr Ser Gly Asp Val Asp Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  31

Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  32

Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 from GL variants

<400>  33

Val Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 from GL variants

<400>  34

Ser Gly Thr Val Arg Gly Phe Ala Tyr 
1               5                   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 from GL variants

<400>  35

Asp Tyr Val Met Tyr 
1               5   


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis tag

<400>  36

His His His His His His 
1               5       


<210>  37
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hum231-32-15VH

<400>  37

Ala Gly Asp Tyr Ala Met Tyr Leu Ile Val Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Asp Val Thr Tyr Asn Gln Lys Phe Lys Asp Ala Lys 
            20                  25              


<210>  38
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Design of ML38


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can be Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be Asp, Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  can be Tyr or His

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  can be Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  can be Ile or Met

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  can be Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  can be Arg, Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  can be Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  can be Asp, Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  can be Val or Leu

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  can be Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  can be Lys, Arg or Gln

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  can be Asp, Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  can be Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  can be Lys or Thr

<400>  38

Xaa Xaa Xaa Tyr Xaa Met Xaa Xaa Xaa Xaa Ile Xaa Thr Xaa Ser Gly 
1               5                   10                  15      


Xaa Xaa Xaa Tyr Asn Gln Lys Phe Xaa Xaa Xaa Xaa 
            20                  25              


<210>  39
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D03

<400>  39

Ala Ala Gly Tyr Ala Met Tyr Met Ile Leu Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Thr Tyr Asn Gln Lys Phe Gln Gly Val Thr 
            20                  25              


<210>  40
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D05

<400>  40

Ala Gly Gly Tyr Ala Met Tyr Met Ile Val Ile Arg Thr Phe Ser Gly 
1               5                   10                  15      


Asp Val Thr Tyr Asn Gln Lys Phe Arg Gly Val Thr 
            20                  25              


<210>  41
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D07

<400>  41

Thr Gly Glu Tyr Ala Met Tyr Met Ile Leu Ile Arg Thr Phe Ser Gly 
1               5                   10                  15      


Glu Val Thr Tyr Asn Gln Lys Phe Lys Asp Val Thr 
            20                  25              


<210>  42
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D08

<400>  42

Thr Gly Gly Tyr Ala Met Tyr Leu Ile Val Ile Lys Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Thr Tyr Asn Gln Lys Phe Arg Gly Val Lys 
            20                  25              


<210>  43
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D09

<400>  43

Ala Gly Gly Tyr Ala Met His Leu Met Leu Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Ser Tyr Asn Gln Lys Phe Arg Glu Ala Thr 
            20                  25              


<210>  44
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E01

<400>  44

Thr Ala Asp Tyr Ala Met Tyr Leu Ile Val Ile Arg Thr Phe Ser Gly 
1               5                   10                  15      


Asp Leu Thr Tyr Asn Gln Lys Phe Gln Asp Val Thr 
            20                  25              


<210>  45
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F09

<400>  45

Ala Ala Glu Tyr Ala Met His Leu Met Leu Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Ser Tyr Asn Gln Lys Phe Gln Gly Ala Thr 
            20                  25              


<210>  46
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10

<400>  46

Thr Ala Asp Tyr Ala Met Tyr Leu Ile Leu Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Thr Tyr Asn Gln Lys Phe Gln Gly Val Thr 
            20                  25              


<210>  47
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G01

<400>  47

Thr Gly Asp Tyr Ala Met Tyr Met Met Val Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Asp Val Ser Tyr Asn Gln Lys Phe Arg Gly Val Thr 
            20                  25              


<210>  48
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G05

<400>  48

Ala Ala Glu Tyr Ala Met Tyr Leu Met Leu Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Ser Tyr Asn Gln Lys Phe Arg Asp Val Lys 
            20                  25              


<210>  49
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B07

<400>  49

Ala Ala Gly Tyr Ala Met Tyr Met Met Val Ile Arg Thr Phe Ser Gly 
1               5                   10                  15      


Gly Val Thr Tyr Asn Gln Lys Phe Arg Gly Ala Thr 
            20                  25              


<210>  50
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C03

<400>  50

Thr Gly Asp Tyr Ala Met Tyr Met Ile Val Ile Lys Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Thr Tyr Asn Gln Lys Phe Lys Asp Ala Thr 
            20                  25              


<210>  51
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F07

<400>  51

Thr Gly Asp Tyr Ala Met Tyr Leu Ile Val Ile Arg Thr Phe Ser Gly 
1               5                   10                  15      


Glu Val Thr Tyr Asn Gln Lys Phe Gln Glu Val Ala 
            20                  25              


<210>  52
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D11

<400>  52

Thr Ala Glu Tyr Ala Met Tyr Met Ile Val Ile Arg Thr Phe Ser Gly 
1               5                   10                  15      


Gly Val Thr Tyr Asn Gln Lys Phe Gln Glu Val Lys 
            20                  25              


<210>  53
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant F08

<400>  53

Ala Ala Glu Tyr Ala Met His Leu Met Val Ile Arg Thr Tyr Ser Gly 
1               5                   10                  15      


Gly Val Ser Tyr Asn Gln Lys Phe Gln Glu Val Thr 
            20                  25              


<210>  54
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hum231-32-15VK

<400>  54

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Leu Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  55
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Design of ML39


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Gly or Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Gln or His

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  His or Tyr

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Tyr, Phe or Ser

<400>  55

Lys Ser Ser Gln Ser Leu Leu Asn Ser Xaa Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Xaa Trp Xaa Gln Xaa Trp Ala Ser Thr Arg Glu Ser Xaa Gly Xaa Gln 
            20                  25                  30          


Xaa Gln Asn Xaa Tyr Ser Xaa Pro Tyr Thr 
        35                  40          


<210>  56
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D03

<400>  56

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser Trp His Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Val Gln 
            20                  25                  30          


His Gln Asn Glu Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  57
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D05

<400>  57

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp His Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Val Gln 
            20                  25                  30          


Tyr Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  58
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D07

<400>  58

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Leu Gln 
            20                  25                  30          


His Gln Asn Glu Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  59
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D08

<400>  59

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Leu Gln 
            20                  25                  30          


Tyr Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  60
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D09

<400>  60

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Val Gln 
            20                  25                  30          


His Gln Asn Glu Tyr Ser Phe Pro Tyr Thr 
        35                  40          


<210>  61
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E01

<400>  61

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Leu Gln 
            20                  25                  30          


Tyr Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  62
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F09

<400>  62

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Val Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Phe Pro Tyr Thr 
        35                  40          


<210>  63
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10

<400>  63

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Val Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Phe Pro Tyr Thr 
        35                  40          


<210>  64
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G05

<400>  64

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser Trp His Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Val Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  65
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n/a

<400>  65

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Val Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  66
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G09

<400>  66

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser Trp His Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Val Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  67
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11

<400>  67

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Leu Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  68
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F02

<400>  68

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Leu Gln 
            20                  25                  30          


Tyr Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  69
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F03

<400>  69

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Met Trp Ala Ser Thr Arg Glu Ser Ser Gly Leu Gln 
            20                  25                  30          


Tyr Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
        35                  40          


<210>  70
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D07

<400>  70

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Thr Gly Leu Gln 
            20                  25                  30          


Tyr Gln Asn Asp Tyr Ser Phe Pro Tyr Thr 
        35                  40          


<210>  71
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant F05

<400>  71

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr Trp Gln Gln Leu Trp Ala Ser Thr Arg Glu Ser Ser Gly Leu Gln 
            20                  25                  30          


His Gln Asn Asp Tyr Ser Phe Pro Tyr Thr 
        35                  40          


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope

<400>  72

Asp Tyr Pro Gly 
1               


<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 from GL variants

<400>  101

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser 
    


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 from GL variants

<400>  102

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 from GL variants

<400>  103

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 from GL variants

<400>  104

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ser 
    


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 from GL variants

<400>  105

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 from GL variants

<400>  106

Gln Asn Glu Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 from GL variants

<400>  107

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 from GL variants

<400>  108

Gln Asn Glu Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 from GL variants

<400>  109

Gln Asn Asp Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  114

Val Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  115

Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  116

Gly Tyr Val Met Tyr 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  117

Asp Tyr Ala Met His 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  118

Glu Tyr Val Met His 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  119

Gly Tyr Val Met His 
1               5   


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  120

Ile Ile Lys Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  121

Leu Ile Gln Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  122

Leu Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  123

Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  124

Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  125

Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  126

Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  127

Leu Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  128

Leu Ile Arg Thr Phe Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  129

Leu Ile Arg Thr Phe Ser Gly Glu Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  130

Leu Ile Arg Thr Phe Ser Gly Glu Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  131

Leu Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  132

Leu Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  133
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  133

Leu Ile Arg Thr Phe Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  134

Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Glu 
    


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  135

Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  136

Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  137
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  137

Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  138

Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  139

Leu Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  140

Leu Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  141
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  141

Leu Ile Arg Thr Tyr Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Glu 
    


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  142

Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  143

Leu Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  144

Leu Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  145

Leu Ile Arg Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  146
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  146

Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  147
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  147

Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  148
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  148

Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  149
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  149

Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Glu 
    


<210>  150
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  150

Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  151
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  151

Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  152

Val Ile Lys Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  153
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  153

Val Ile Lys Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  154

Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  155
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  155

Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  156
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  156

Val Ile Gln Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  157

Val Ile Gln Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  158
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  158

Val Ile Gln Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  159

Val Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  160
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  160

Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  161
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  161

Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  162
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  162

Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  163

Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  164
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  164

Val Ile Arg Thr Phe Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  165
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  165

Val Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  166

Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  167
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  167

Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  168

Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  169
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  169

Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  170
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  170

Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  171

Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  172
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  172

Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  173

Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  174

Val Ile Arg Thr Tyr Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  175

Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  176
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  176

Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  177
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  177

Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  178
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  178

Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  179
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  179

Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Glu 
    


<210>  180
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  180

Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  181
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  181

Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Glu 
    


<210>  182
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  182

Val Ile Arg Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  183

Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  184

Val Ile Arg Thr Tyr Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  185
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  185

Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  186
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  186

Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  187
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  187

Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  188

Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  189

Ser Gly Thr Val Arg Gly Phe Ala Asp 
1               5                   


<210>  190

<400>  190
000

<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  191

Gln Asn Asp His Ser Phe Pro Tyr Thr 
1               5                   


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  192

Gln Asn Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  193

Gln Asn Glu Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  194
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  194

Val Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse VH

<400>  201

Gln Val Gln Leu Leu Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Ser Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  202
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse VL

<400>  202

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Ile Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  203
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VH consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  can be Aspartic Acid, Glutamic Acid, or Glycine

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  can be Alanine or Valine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  can be Tyrosine or Histidine

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  can be Valine or Leucine

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  can be Arginine, Lysine, or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  can be Tyrosine or Phenylalanine

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  can be Aspartic Acid, Glutamic Acid, or Glycine

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  can be Valine or Leucine

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  can be Threonine or Serine

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  can be Lysine, Arginine or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  can be Aspartic Acid, Glutamic Acid, or Glycine

<400>  203

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Xaa Tyr 
            20                  25                  30          


Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Ile Xaa Thr Xaa Ser Gly Xaa Xaa Xaa Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Xaa Xaa Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  204
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VK A1 consensus seq


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  can be Leucine or Valine

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  can be Leucine, Isoleucine, Serine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  can be Asparagine, Glutamine, Serine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  can be Serine, Threonine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  can be Asparagine or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  can be Asparagine or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  can be Threonine, Serine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  can be Tryptophan, Tyrosine, Phenylalanine, Glycine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  can be Glutamic Acid or Alanine

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  can be Serine, Threonine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  can be Asparagine or Glutamine

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  can be Serine, Threonine, or Alanine

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  can be Tyrosine, Phenylalanine, Leucine, or Alanine

<400>  204

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Xaa Xaa Xaa Xaa 
            20                  25                  30          


Gly Xaa Gln Lys Xaa Tyr Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Xaa Xaa Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys Gln Xaa 
                85                  90                  95      


Asp Tyr Xaa Xaa Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  205
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VK A2 consensus seq


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  can be Glycine or Serine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  can be Threonine or Serine

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  can be Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  can be Tyrosine, Phenylalanine, or Serine

<400>  205

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Xaa Asn Gln Lys Asn Tyr Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Xaa Tyr Ser Xaa Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  206
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Version VH

<400>  206

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  207
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Version VK A1

<400>  207

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  208
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Version VK A2

<400>  208

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  209
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Version VH A

<400>  209
atggattgga cctggcggat cctgttcctg gtggccgctg ctacaggcgc ccattctcag       60

gtgcagctgg tgcagtctgg cgccgaagtg aagaaaccag gcgccagcgt gaaggtgtcc      120

tgcaagggca gcggctacac attcaccgac tacgccatgt actgggtgcg acaggctcct      180

ggacagggcc tggaatggat cggcgtgatc agaacctaca gcggcgacgt gacctacaac      240

cagaagttca aggacagagc caccatgacc gtggacaaga gcatcagcac cgcctacatg      300

gaactgagca gactgagaag cgacgacacc gccgtgtact actgcgccaa gtctggcaca      360

gtgcggggct tcgcttactg gggccagggc acactcgtga ccgtgtcgag c               411


<210>  210
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Version VK A1

<400>  210
atggaaaccc ctgcccagct gctgttcctg ctgctgctgt ggctgcctga caccaccggc       60

gacatcgtga tgacccagag ccctcctacc ctgagcctga gccctggcga gagagtgacc      120

ctgagctgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctgacc      180

tggtatcagc agaagcccgg ccaggccccc agactgctga tctactgggc cagcacaaga      240

gagagcggca tccccgccag attcagcgga tctggcagcg gcaccgactt caccctgacc      300

atctctagcc tgcagcccga ggacttcgcc gtgtaccact gccagaacga ctacagctac      360

ccctacacct tcggccaggg caccaagctg gaaatcaag                             399


<210>  211
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Version VK A2

<400>  211
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatcagcgg cgcctacggc       60

gacatcgtga tgacccagag ccctgacagc ctggccgtgt ctctgggcga gagagccacc      120

atcaactgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctgacc      180

tggtatcagc agaagcccgg ccagcccccc aagctgctga tctactgggc cagcaccaga      240

gaaagcggcg tgcccgacag attcagcggc agcggctctg gaaccgactt caccctgacc      300

atcagctccc tgcaggccga ggatgtggcc gtgtaccact gccagaacga ctacagctac      360

ccctacacct tcggccaggg caccaagctg gaaatcaag                             399


<210>  212

<400>  212
000

<210>  213

<400>  213
000

<210>  214

<400>  214
000

<210>  215
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH regions from germlined variants

<400>  215

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  216
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH regions from germlined variants

<400>  216

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Leu Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  217
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 2

<400>  217

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  218
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 3

<400>  218

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  219
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 4

<400>  219

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  220
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 5

<400>  220

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  221
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 6

<400>  221

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  222
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 7

<400>  222

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  223
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 8

<400>  223

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Lys Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  224
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 9

<400>  224

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  225
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 10

<400>  225

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  226
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 11

<400>  226

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  227
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 12

<400>  227

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  228
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 13

<400>  228

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  229
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 14

<400>  229

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  230
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 15

<400>  230

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  231
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 16

<400>  231

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  232
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 17

<400>  232

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Gln Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  233
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 18

<400>  233

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Glu Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  234
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 19

<400>  234

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  235
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  235

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  236
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 20

<400>  236

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  237
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 21

<400>  237

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  238
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 22

<400>  238

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  239
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 23

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  240
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 24

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ala Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  241
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 25

<400>  241

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  242
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 26

<400>  242

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  243
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 27

<400>  243

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  244
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 28

<400>  244

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  245
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 29

<400>  245

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  246
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 30

<400>  246

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  247
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 31

<400>  247

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Pro Val Thr Val Ser Ser 
        115             


<210>  248
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 32

<400>  248

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  249
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 33

<400>  249

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  250
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 34

<400>  250

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  251
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 35

<400>  251

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ala Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  252
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 36

<400>  252

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  253
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 37

<400>  253

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Glu Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  254
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 38

<400>  254

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  255
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 39

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Ile Thr Val Ser Ser 
        115             


<210>  256
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 40

<400>  256

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  257
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  257

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  258
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 41

<400>  258

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  259
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 42

<400>  259

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Leu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  260
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  260

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  261
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 43

<400>  261

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  262
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 44

<400>  262

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  263
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 45

<400>  263

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Phe Val Thr Val Ser Ser 
        115             


<210>  264
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 46

<400>  264

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  265
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 47

<400>  265

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  266
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  266

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  267
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 48

<400>  267

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  268
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 49

<400>  268

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  269
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  269

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  270
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 50

<400>  270

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  271
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 51

<400>  271

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  272
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 52

<400>  272

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  273
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 53

<400>  273

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  274
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  274

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Glu Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Ala Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  275
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  275

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  276
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 54

<400>  276

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  277
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 55

<400>  277

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  278
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  278

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  279
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  279

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  280
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 56

<400>  280

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  281
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 57

<400>  281

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  282
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  282

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  283
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 58

<400>  283

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  284
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 59

<400>  284

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  285
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 60

<400>  285

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Lys Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  286
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  286

Gln Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Pro Gly Arg Gly Ser Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  287
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 61

<400>  287

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  288
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 62

<400>  288

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  289
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  289

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  290
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 63

<400>  290

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  291
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 64

<400>  291

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  292
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  292

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  293
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  293

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  294
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  294

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  295
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  295

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  296
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 66

<400>  296

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  297
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 67

<400>  297

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Gln Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  298
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 68

<400>  298

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  299
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 69

<400>  299

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  300
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  300

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  301
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 70

<400>  301

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  302
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  302

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Gln Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  303
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  303

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  304
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 71

<400>  304

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  305
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 72

<400>  305

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  306
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 73

<400>  306

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Lys Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  307
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  307

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  308
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 74

<400>  308

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  309
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  309

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  310
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  310

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  311
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  311

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  312
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  312

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Gln Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  313
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 75

<400>  313

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  314
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 76

<400>  314

Gln Val Gln Leu Val Gln Ser Gly Ala Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  315
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 77

<400>  315

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Gln Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  316
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 78

<400>  316

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Lys Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  317
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  317

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  318
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  318

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  319
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 79

<400>  319

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  320
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 80

<400>  320

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  321
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  321

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  322
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 81

<400>  322

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  323
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 82

<400>  323

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  324
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 83

<400>  324

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  325
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 84

<400>  325

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  326
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  326

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  327
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 85

<400>  327

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  328
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vh Antibody 86

<400>  328

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  329
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  329

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  330
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  330

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  331
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  331

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  332
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  332

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Phe Val Thr Val Ser Ser 
        115             


<210>  333
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 87

<400>  333

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  334
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  334

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  335
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  335

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  336
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 88

<400>  336

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  337
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  337

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Glu Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  338
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 89

<400>  338

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  339
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 90

<400>  339

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  340
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 91

<400>  340

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  341
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  341

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  342
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 92

<400>  342

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Gln Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  343
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 93

<400>  343

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Gln Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  344
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  344

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  345
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pab1979, VH; pab1980, VH; pab1981, VH

<400>  345

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  346
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  346

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Lys Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Val Thr Met Thr Val Asp Lys Asn Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  347
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  347

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  348
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  348

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  349
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  349

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  350
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 94

<400>  350

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Phe Val Thr Val Ser Ser 
        115             


<210>  351
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  351

Gln Val Arg Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  352
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  352

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  353
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  353

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Gly Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  354
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 95

<400>  354

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Phe Val Thr Val Ser Ser 
        115             


<210>  355
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 96

<400>  355

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  356
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 97

<400>  356

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  357
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  357

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  358
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 98

<400>  358

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  359
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 99

<400>  359

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  360
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 100

<400>  360

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  361
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  361

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  362
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 101

<400>  362

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  363
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 102

<400>  363

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  364
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 103

<400>  364

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  365
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 104

<400>  365

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  366
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 105

<400>  366

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  367
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 106

<400>  367

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  368
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Antibody 107

<400>  368

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  369
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  369

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Glu Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  370
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  370

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  371
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  371

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  372
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  372

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  373
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  373

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  374
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  374

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Lys Thr Phe Ser Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  375
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  375

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Glu Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  376
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  376

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  377
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  377

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  378
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  378

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Lys Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  379
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  379

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  380
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  380

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  381
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  381

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Gln Thr Phe Ser Gly Gly Leu Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  382
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  382

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Lys Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  383
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  383

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Arg Thr Phe Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  384
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  384

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  385
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  385

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Phe Ser Gly Gly Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Ile Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  386
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  386

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  387
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  387

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Glu Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  388
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  388

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asn Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  389
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  389

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  390

<400>  390
000

<210>  391

<400>  391
000

<210>  392

<400>  392
000

<210>  393

<400>  393
000

<210>  394

<400>  394
000

<210>  395

<400>  395
000

<210>  396

<400>  396
000

<210>  397

<400>  397
000

<210>  398

<400>  398
000

<210>  399

<400>  399
000

<210>  400
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 1

<400>  400

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  401
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 2

<400>  401

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  402
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 3

<400>  402

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  403
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 4

<400>  403

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  404
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 5

<400>  404

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Ala Pro Gly Glu 
1               5                   10                  15      


Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser 
            20                  25                  30          


Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn Glu 
                85                  90                  95      


Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  405
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 6

<400>  405

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  406
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 7

<400>  406

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  407
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8

<400>  407

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  408
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 9

<400>  408

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  409
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 10

<400>  409

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  410
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 11

<400>  410

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  411
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 12

<400>  411

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  412
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  412

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  413
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 13

<400>  413

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  414
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 14

<400>  414

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  415
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 15

<400>  415

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  416
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 16

<400>  416

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  417
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  417

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  418
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 17

<400>  418

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  419
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 18

<400>  419

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  420
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 19

<400>  420

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  421
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 20

<400>  421

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Leu Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  422
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  422

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  423
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 21

<400>  423

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  424
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 22

<400>  424

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp His Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  425
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 23

<400>  425

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  426
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 24

<400>  426

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  427
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 25

<400>  427

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  428
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 26

<400>  428

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  429
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 27

<400>  429

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  430
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 28

<400>  430

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  431
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 29

<400>  431

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  432
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 30

<400>  432

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  433
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 31

<400>  433

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  434
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 32

<400>  434

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  435
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 33

<400>  435

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  436
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 34

<400>  436

Asp Ile Val Met Thr Gln Ser Thr Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  437
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 35

<400>  437

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  438
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 36

<400>  438

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Glu Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  439
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 37

<400>  439

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  440
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 38

<400>  440

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  441
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 39

<400>  441

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  442
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 40

<400>  442

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  443
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 41

<400>  443

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  444
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 42

<400>  444

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  445
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 43

<400>  445

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  446
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 44

<400>  446

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  447
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 45

<400>  447

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  448
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 46

<400>  448

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  449
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  449

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  450
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 47

<400>  450

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  451
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 48

<400>  451

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  452
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 49

<400>  452

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  453
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  453

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  454
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 50

<400>  454

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  455
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 51

<400>  455

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  456
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 52

<400>  456

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  457
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 53

<400>  457

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  458
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 54

<400>  458

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  459
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 55

<400>  459

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  460
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 56

<400>  460

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  461
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 57

<400>  461

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  462
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 58

<400>  462

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  463
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 59

<400>  463

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  464
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 60

<400>  464

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  465
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  465

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  466
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  466

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  467
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 61

<400>  467

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  468
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 62

<400>  468

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  469
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 63

<400>  469

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  470
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 64

<400>  470

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  471
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 65

<400>  471

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Phe Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  472
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 66

<400>  472

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  473
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 67

<400>  473

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  474
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 68

<400>  474

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  475
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 69

<400>  475

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  476
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 70

<400>  476

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  477
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 71

<400>  477

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  478
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  478

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Thr Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  479
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  479

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  480
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  480

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Pro Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  481
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 72

<400>  481

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  482
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 73

<400>  482

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  483
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 74

<400>  483

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  484
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 75

<400>  484

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  485
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 76

<400>  485

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  486
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 77

<400>  486

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  487
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  487

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  488
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 78

<400>  488

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  489
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 79

<400>  489

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  490
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 80

<400>  490

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  491
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 81

<400>  491

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  492

<400>  492
000

<210>  493
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 83

<400>  493

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  494
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 84

<400>  494

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  495
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 85

<400>  495

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  496
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 86

<400>  496

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  497
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 87

<400>  497

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  498
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 88

<400>  498

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  499
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 89

<400>  499

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  500
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 90

<400>  500

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  501
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 91

<400>  501

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  502
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 92

<400>  502

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  503
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 93

<400>  503

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  504
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 94

<400>  504

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  505
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 95

<400>  505

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  506
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 96

<400>  506

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  507
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 97

<400>  507

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  508
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 98

<400>  508

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  509
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 99

<400>  509

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  510
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 100

<400>  510

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  511
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 101

<400>  511

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  512
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 102

<400>  512

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  513
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 103

<400>  513

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  514
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  514

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  515
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 104

<400>  515

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Glu Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  516
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 105

<400>  516

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  517
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 106

<400>  517

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Ser Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  518
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Antibody 107

<400>  518

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ser Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  519
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pab1973, VL

<400>  519

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527

<400>  527
000

<210>  528

<400>  528
000

<210>  529

<400>  529
000

<210>  530

<400>  530
000

<210>  531

<400>  531
000

<210>  532

<400>  532
000

<210>  533

<400>  533
000

<210>  534

<400>  534
000

<210>  535

<400>  535
000

<210>  536

<400>  536
000

<210>  537

<400>  537
000

<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544

<400>  544
000

<210>  545

<400>  545
000

<210>  546

<400>  546
000

<210>  547

<400>  547
000

<210>  548

<400>  548
000

<210>  549

<400>  549
000

<210>  550

<400>  550
000

<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain


<220>
<221>  MISC_FEATURE
<222>  (215)..(215)
<223>  can be Lysine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  can be Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (359)..(359)
<223>  can be Leucine or Methionine

<220>
<221>  MISC_FEATURE
<222>  (432)..(432)
<223>  can be Glycine or Alanine

<400>  553

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Xaa Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Xaa Glu Xaa Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Xaa 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  554
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain

<400>  554

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  555
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain


<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  can be Valine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  can be Leucine or Valine

<400>  555

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Xaa Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Xaa Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  556
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(220)
<223>  Full-length humanized light chain

<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  can be Valine or Alanine

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  can be Leucine or Valine

<400>  556

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Xaa Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Xaa Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  557
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 constant region consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  can be Lysine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (239)..(239)
<223>  can be Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (241)..(241)
<223>  can be Leucine or Methionine

<220>
<221>  MISC_FEATURE
<222>  (314)..(314)
<223>  can be Glycine or Alanine

<400>  557

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Xaa Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Xaa Glu 
225                 230                 235                 240 


Xaa Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Xaa Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  558
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 G1m3 allotype

<400>  558

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  559
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 G1m17,1 allotype

<400>  559

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  560
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1, G1m17,1,2 allotype

<400>  560

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  561
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 wt constant regions

<400>  561

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Ser Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  562
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 constant regions S228P modification

<400>  562

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  563
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  can be V or A

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  can be L or V

<400>  563

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Xaa Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Xaa Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  564
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region IGKC*06 Km1 allotype

<400>  564

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Val Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  565
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region IGKC*04 Km1,2 allotype

<400>  565

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  566
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region IGKC*01 Km3 allotype

<400>  566

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  567
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain

<400>  567

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  568
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain

<400>  568

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  569
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain

<400>  569

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Gly 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  570
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain

<400>  570

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Ser Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  571
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain

<400>  571

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Val Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  572
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain

<400>  572

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  573
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain

<400>  573

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  574
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain

<400>  574

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Val Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  575
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain

<400>  575

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  576
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain

<400>  576

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  577
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntheic peptide

<400>  577

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Leu Gln Ser Gly Thr Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ala Met Tyr Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Ile Ala Tyr Met Glu Leu Ala Arg Leu Ser Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Lys Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Tyr Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  578
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  578

Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Ile Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


His Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ser Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  579
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length heavy chain

<400>  579

Gln Val Gln Leu Leu Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr 
 65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Ser Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
 145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  580
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length light chain

<400>  580

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Ile Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  581
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanzied heavy chain

<400>  581

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  582
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized heavy chain

<400>  582

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Arg Thr Tyr Ser Gly Asp Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Gly Thr Val Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  583
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 constant regions

<400>  583

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  584
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2 constant regions C127S modification

<400>  584

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  585
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m6C8 full-length heavy chain

<400>  585

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Ala Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Arg Arg Tyr Phe Pro Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  586
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m6C8 full-length light chain

<400>  586

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Asp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ser Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  587
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length humanized light chain containing T to S mutation

<400>  587

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  588
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Consensus sequence

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  can be valine or alanine

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  can be valine or leucine

<400>  588

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Xaa Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Xaa Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  589
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region IGKC*06 Km1 allotype

<400>  589

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Val Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  590
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region IGKC*04 Km1,2 allotype

<400>  590

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  591
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa light chain constant region IGKC*01 Km3 allotype

<400>  591

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594

<400>  594
000

<210>  595

<400>  595
000

<210>  596

<400>  596
000

<210>  597

<400>  597
000

<210>  598

<400>  598
000

<210>  599

<400>  599
000

<210>  600

<400>  600
000

<210>  601
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGHV1-2*02 (DP75)

<400>  601

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  602
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGHGV1-3*01

<400>  602

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  603
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGHV1-46*01

<400>  603

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  604
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGHV1-18*01

<400>  604

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  605
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGHV1-69*01

<400>  605

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  606
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGHV7-4-1*02

<400>  606

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  607
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGKV4-1*01

<400>  607

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr 
            100 


<210>  608
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germline sequence: IGKV3-7*02

<400>  608

Glu Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu 
                85                  90                  95  


<210>  609

<400>  609
000

<210>  610
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  610

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Ala Pro Gly Glu 
1               5                   10                  15      


Arg Ala Thr Ile Asn Cys 
            20          


<210>  611
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  611

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  612
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  612

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  613
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  613

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  614

<400>  614
000

<210>  615
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  615

Asp Ile Val Met Thr Gln Ser Pro Pro Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys 
            20              


<210>  616
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  616

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Ile Met Ser Cys 
            20              


<210>  617
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR2

<400>  617

Asp Ile Val Met Thr Gln Ser Thr Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  618
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR2

<400>  618

Trp Tyr His Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  619
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  619

Val Leu Phe Arg 
1               


<210>  620
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR1

<400>  620

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  621

<400>  621
000

<210>  622
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR2

<400>  622

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  623
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR2

<400>  623

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  624
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR2

<400>  624

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Met Leu Ile Tyr 
1               5                   10                  15  


<210>  625
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR2

<400>  625

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Ser Leu Ile Tyr 
1               5                   10                  15  


<210>  626
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  626

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr His Cys 
            20                  25                  30          


<210>  627
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  627

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Asp Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  628
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  628

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Phe Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  629
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  629

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Phe Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  630
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  630

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  631
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  631

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  632
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  632

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  633
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  633

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  634
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  634

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Glu Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  635
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  635

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  636
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  636

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  637
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  637

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr His Cys 
            20                  25                  30          


<210>  638
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  638

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr His Cys 
            20                  25                  30          


<210>  639
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  639

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  640

<400>  640
000

<210>  641
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR4

<400>  641

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  642
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR3

<400>  642

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  643
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL FR4

<400>  643

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  644
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  644

Gln Val Gln Leu Val Gln Ser Gly Ala Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  645
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  645

Gln Val Gln Leu Leu Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  646
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  646

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ala Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  647
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  647

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ala Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  648
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  648

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  649
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  649

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  650
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  650

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  651
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR1

<400>  651

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  652
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  652

Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  653
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  653

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  654
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  654

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  655
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  655

Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Ile Gly 
1               5                   10                  


<210>  656
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  656

Trp Val Arg Gln Ala Pro Gly Gln Gly Met Glu Trp Met Gly 
1               5                   10                  


<210>  657
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR2

<400>  657

Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  658
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  658

Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ala Arg Leu Ser Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  659
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  659

Arg Ala Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  660
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  660

Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Gln Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  661
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  661

Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Gly Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  662
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  662

Arg Val Thr Met Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  663
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  663

Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  664
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  664

Trp Gly Gln Gly Ile Pro Val Thr Val Ser Ser 
1               5                   10      


<210>  665
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  665

Trp Gly Gln Gly Thr Phe Val Thr Val Ser Ser 
1               5                   10      


<210>  666
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  666

Trp Gly Gln Gly Thr Phe Val Thr Val Ser Ser 
1               5                   10      


<210>  667
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  667

Trp Gly Gln Gly Thr Leu Ile Thr Val Ser Ser 
1               5                   10      


<210>  668
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  668

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  669
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR4

<400>  669

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  670
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH FR3

<400>  670

Arg Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678

<400>  678
000

<210>  679

<400>  679
000

<210>  680

<400>  680
000

<210>  681

<400>  681
000

<210>  682

<400>  682
000

<210>  683

<400>  683
000

<210>  684

<400>  684
000

<210>  685

<400>  685
000

<210>  686

<400>  686
000

<210>  687

<400>  687
000

<210>  688

<400>  688
000

<210>  689

<400>  689
000

<210>  690

<400>  690
000

<210>  691

<400>  691
000

<210>  692

<400>  692
000

<210>  693

<400>  693
000

<210>  694

<400>  694
000

<210>  695

<400>  695
000

<210>  696

<400>  696
000

<210>  697

<400>  697
000

<210>  698
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V1M cynomolgus GITR immature protein

<400>  698

Met Ala Arg His Gly Ala Met Cys Ala Cys Gly Thr Leu Cys Cys Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Ala Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Lys Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Pro Thr Arg Cys Cys Arg Asp Tyr Gln Ser Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Val Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asn Pro Cys Cys Thr Thr Cys Gln His His Pro Cys Pro Ser 
                85                  90                  95      


Gly Gln Gly Val Gln Pro Gln Gly Lys Phe Ser Phe Gly Phe Arg Cys 
            100                 105                 110         


Val Asp Cys Ala Leu Gly Thr Phe Ser Arg Gly His Asp Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Pro Gly Trp Leu Thr Ile Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Gly Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Ser Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Leu Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  699
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V1M/Q62P/S63G cynomolgus GITR immature protein

<400>  699

Met Ala Arg His Gly Ala Met Cys Ala Cys Gly Thr Leu Cys Cys Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Ala Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Lys Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Pro Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Val Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asn Pro Cys Cys Thr Thr Cys Gln His His Pro Cys Pro Ser 
                85                  90                  95      


Gly Gln Gly Val Gln Pro Gln Gly Lys Phe Ser Phe Gly Phe Arg Cys 
            100                 105                 110         


Val Asp Cys Ala Leu Gly Thr Phe Ser Arg Gly His Asp Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Pro Gly Trp Leu Thr Ile Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Gly Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Ser Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Leu Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  700
<211>  216
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(216)
<223>  human GITR mature protein

<400>  700

Gln Arg Pro Thr Gly Gly Pro Gly Cys Gly Pro Gly Arg Leu Leu Leu 
1               5                   10                  15      


Gly Thr Gly Thr Asp Ala Arg Cys Cys Arg Val His Thr Thr Arg Cys 
            20                  25                  30          


Cys Arg Asp Tyr Pro Gly Glu Glu Cys Cys Ser Glu Trp Asp Cys Met 
        35                  40                  45              


Cys Val Gln Pro Glu Phe His Cys Gly Asp Pro Cys Cys Thr Thr Cys 
    50                  55                  60                  


Arg His His Pro Cys Pro Pro Gly Gln Gly Val Gln Ser Gln Gly Lys 
65                  70                  75                  80  


Phe Ser Phe Gly Phe Gln Cys Ile Asp Cys Ala Ser Gly Thr Phe Ser 
                85                  90                  95      


Gly Gly His Glu Gly His Cys Lys Pro Trp Thr Asp Cys Thr Gln Phe 
            100                 105                 110         


Gly Phe Leu Thr Val Phe Pro Gly Asn Lys Thr His Asn Ala Val Cys 
        115                 120                 125             


Val Pro Gly Ser Pro Pro Ala Glu Pro Leu Gly Trp Leu Thr Val Val 
    130                 135                 140                 


Leu Leu Ala Val Ala Ala Cys Val Leu Leu Leu Thr Ser Ala Gln Leu 
145                 150                 155                 160 


Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu 
                165                 170                 175     


Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser 
            180                 185                 190         


Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys 
        195                 200                 205             


Gly Arg Leu Gly Asp Leu Trp Val 
    210                 215     


<210>  701
<211>  241
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(241)
<223>  Human GITR (Isoform 1)

<400>  701

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  702
<211>  255
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(255)
<223>  Human GITR (Isoform 2)

<400>  702

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Cys Trp Arg Cys Arg Arg Arg Pro Lys Thr 
    130                 135                 140                 


Pro Glu Ala Ala Ser Ser Pro Arg Lys Ser Gly Ala Ser Asp Arg Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Gly Trp Glu Thr Cys Gly Cys Glu Pro Gly Arg Pro 
                165                 170                 175     


Pro Gly Pro Pro Thr Ala Ala Ser Pro Ser Pro Gly Ala Pro Gln Ala 
            180                 185                 190         


Ala Gly Ala Leu Arg Ser Ala Leu Gly Arg Ala Leu Leu Pro Trp Gln 
        195                 200                 205             


Gln Lys Trp Val Gln Glu Gly Gly Ser Asp Gln Arg Pro Gly Pro Cys 
    210                 215                 220                 


Ser Ser Ala Ala Ala Ala Gly Pro Cys Arg Arg Glu Arg Glu Thr Gln 
225                 230                 235                 240 


Ser Trp Pro Pro Ser Ser Leu Ala Gly Pro Asp Gly Val Gly Ser 
                245                 250                 255 


<210>  703
<211>  234
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(234)
<223>  Human GITR (Isoform 3)

<400>  703

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  704
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus GITR immature protein

<400>  704

Val Ala Arg His Gly Ala Met Cys Ala Cys Gly Thr Leu Cys Cys Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Ala Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Lys Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Pro Thr Arg Cys Cys Arg Asp Tyr Gln Ser Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Val Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asn Pro Cys Cys Thr Thr Cys Gln His His Pro Cys Pro Ser 
                85                  90                  95      


Gly Gln Gly Val Gln Pro Gln Gly Lys Phe Ser Phe Gly Phe Arg Cys 
            100                 105                 110         


Val Asp Cys Ala Leu Gly Thr Phe Ser Arg Gly His Asp Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Pro Gly Trp Leu Thr Ile Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Gly Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Ser Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Leu Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  705
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 892-Je

<400>  705
gaccaataga aactgggctt gtc                                               23


<210>  706
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 327-Je

<400>  706
ctcgatcctc cctttatcca g                                                 21


<210>  707
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 89-AL

<400>  707
gcctccgcct cctcttcctc catcc                                             25


<210>  708
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1192-Je

<400>  708
tctgctcttc taccatggat tggacttggc gcattctgtt c                           41


<210>  709
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1193-Je

<400>  709
cttgctcttc tatggtgtta cagactcagg tgttc                                  35


<210>  710
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1060-Je

<400>  710
tacgctcttc aagctgctgg agggcacgg                                         29


<210>  711
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1065-Je

<400>  711
cttgctcttc gctcagcgtc agggtgct                                          28


<210>  712
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1152-Je

<400>  712
gagctcctcg aggccaccat g                                                 21


<210>  713
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1204-Je

<400>  713
cgcggccgcg aattctta                                                     18


<210>  714
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1155-Je

<400>  714
ccttgaacct cctcgttcg                                                    19


<210>  715
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  715

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys Met 
65                  70                  75                  80  


Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu 
                85                  90                  95      


Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln 
            100                 105                 110         


Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr 
        115                 120                 125             


Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met 
    130                 135                 140                 


Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr 
145                 150                 155                 160 


Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu 
                165                 170                 175     


His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala 
            180                 185                 190         


Asn Pro Gln Phe Ile Ser 
        195             


<210>  716
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(199)
<223>  human GITRL protein sequence

<400>  716

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  717

<400>  717
000

<210>  718

<400>  718
000

<210>  719

<400>  719
000

<210>  720

<400>  720
000

<210>  721

<400>  721
000

<210>  722

<400>  722
000

<210>  723

<400>  723
000

<210>  724

<400>  724
000

<210>  725

<400>  725
000

<210>  726

<400>  726
000

<210>  727

<400>  727
000

<210>  728

<400>  728
000

<210>  729

<400>  729
000

<210>  730

<400>  730
000

<210>  731

<400>  731
000

<210>  732

<400>  732
000

<210>  733

<400>  733
000

<210>  734

<400>  734
000

<210>  735

<400>  735
000

<210>  736

<400>  736
000

<210>  737

<400>  737
000

<210>  738

<400>  738
000

<210>  739

<400>  739
000

<210>  740

<400>  740
000

<210>  741

<400>  741
000

<210>  742

<400>  742
000

<210>  743

<400>  743
000

<210>  744

<400>  744
000

<210>  745

<400>  745
000

<210>  746

<400>  746
000

<210>  747

<400>  747
000

<210>  748

<400>  748
000

<210>  749

<400>  749
000

<210>  750

<400>  750
000

<210>  751

<400>  751
000

<210>  752

<400>  752
000

<210>  753

<400>  753
000

<210>  754

<400>  754
000

<210>  755

<400>  755
000

<210>  756

<400>  756
000

<210>  757

<400>  757
000

<210>  758

<400>  758
000

<210>  759

<400>  759
000

<210>  760

<400>  760
000

<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  800
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaacctata gtgggggtgt tacttacaac      240

cagaagttcc agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  801
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  801
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaaccttta gtggggaagt ttcttacaac      240

cagaagttcc agggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggcc ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  802
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  802
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttcc ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  803
<211>  412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  803
satggattgg acttggcgca ttctgttcct tgttgctgcc gctactggcg cccattctca       60

ggtgcagttg gtccagtctg gggctgaggt gaagaaaccc ggtgcttcgg tgaaagtgtc      120

ctgcaaaggt tcagggtaca cctttaccgg atatgttatg cattgggtga gacaagcacc      180

tggacaaggc atggagtgga tgggagttat ccgaacctat agtggggaag tttcttacaa      240

ccagaagttc caggaaaggg ttaccatgac ggtggacaag agcatctcca ctgcctacat      300

ggaactgagt cggctacgaa gcgacgatac agcggtatac tactgtgcca aaagcggcac      360

tgtacgtggc tttgcctatt ggggtcaggg aacactcgtc acagtttcga gc              412


<210>  804
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  804
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaagct tggagtggat gggacttatc cgaaccttta gtggggatgt ttcttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  805
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  805
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  806
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  806
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttca agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  807
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  807
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaaccttta gtgggggact ttcttacaac      240

cagaagttcc gggaaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  808
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  808
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgtcatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc aaaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc aggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcatattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  809
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  809
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggaagt ttcttacaac      240

cagaagttca ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  810
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  810
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggagt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  811
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  811
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggtgt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  812
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  812
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaaccttta gtggggaagt ttcttacaac      240

cagaagttca agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  813
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  813
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaaccttta gtggggatgt tacttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  814
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  814
atggattgga cttggcgcat tttgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgtcatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc gggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  815
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  815
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  816
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  816
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc agaaccttta gtgggggtgt tacttacaac      240

cagaagttcc gggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  817
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  817
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc caaaccttta gtgggggtgt tacttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  818
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  818
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaaccttta gtggggaagt tacttacaac      240

cagaagttca ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  819
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  819
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggact ttcttacaac      240

cagaagttcc aggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  820
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  820
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc agaaccttta gtgggggtct tacttacaac      240

cagaagttca agggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  821
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  821
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaaccttta gtggggatct ttcttacaac      240

cagaagttca ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcagggg acactcgtca cagtttcgag c               411


<210>  822
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  822
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgttatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttca gggaaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  823
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  823
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaaccttta gtggggatgt tacttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  824
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  824
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaaccttta gtggggatgt tacttacaac      240

cagaagttcc ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  825
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  825
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagcgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaacctata gtgggggagt tacttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  826
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  826
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtgggggagt ttcttacaac      240

cagaagttcc ggggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  827
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  827
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttca agggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  828
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  828
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  829
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  829
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtgggggagt tacttacaac      240

cagaagttcc ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  830
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  830
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt taaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaaccttta gtgggggtgt tacttacaac      240

cagaagttca agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  831
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  831
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgttatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaaccttta gtgggggtct ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  832
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  832
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtgggggtct tacttacaac      240

cagaagttca aggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga atacccgtca cagtttcgag c               411


<210>  833
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  833
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtgggggtgt tacttacaac      240

cagaagttca aggatagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  834
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  834
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  835
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  835
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc agaaccttta gtgggggagt tacttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  836
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  836
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggcg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaaccttta gtggggatgt tacttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  837
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  837
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  838
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  838
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaaccttta gtggggaagt tacttacaac      240

cagaagttca aggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  839
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  839
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc aaaacctata gtgggggagt tacttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  840
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  840
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtgggggagt ttcttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcatca cagtttcgag c               411


<210>  841
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  841
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaacctata gtggggatct ttcttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  842
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  842
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc agaaccttta gtgggggtgt tacttacaac      240

cagaagttcc aggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  843
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  843
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgttatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttca ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  844
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  844
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtggggatct tacttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  845
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  845
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaacctata gtggggaagt ttcttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  846
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  846
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttca agggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  847
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  847
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  848
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  848
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttcc agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acattcgtca cagtttcgag c               411


<210>  849
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  849
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaaccttta gtggggatct ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  850
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  850
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccactctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgccgattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  851
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  851
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaacctata gtgggggagt tacttacaac      240

cagaagttca ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  852
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  852
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggtgt tacttacaac      240

cagaagttca aggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  853
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  853
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaacctata gtggggatgt tacttacaac      240

cagaagttca gggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  854
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  854
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaacctata gtggggaagt ttcttacaac      240

cagaagttcc agggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  855
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  855
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc cgaaccttta gtgggggagt ttcttacaac      240

cagaagttca aggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  856
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  856
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaaccttta gtgggggagt tacttacaac      240

cagaagttca agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  857
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  857
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgcaatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggtgt ttcttacaac      240

cagaagttca gggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  858
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  858
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaacctata gtgggggtct ttcttacaac      240

cagaagttca ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  859
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  859
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtggggaagt tacttacaac      240

cagaagttcc aggaaagggt taccatgacg gtggacgcga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  860
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  860
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaaccttta gtggggatgt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  861
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  861
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggtgt ttcttacaac      240

cagaagttcc agggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgctaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  862
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  862
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc cgaacctata gtgggggtgt tacttacaac      240

cagaagttcc agggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  863
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  863
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaacctata gtggggatgt tacttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgcggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  864
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  864
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc aaaacctata gtgggggtgt tacttacaac      240

cagaagttca agggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  865
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  865
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttca ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  866
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  866
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaacctata gtggggatgt tacttacaac      240

cagaagttca aggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  867
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  867
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc agaacctata gtgggggagt ttcttacaac      240

cagaagttcc gggaaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  868
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  868
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaacctata gtgggggtgt tacttacaac      240

cagaagttca agggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  869
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  869
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtgggggagt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  870
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  870
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc aaaacctata gtgggggtgt ttcttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  871
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  871
atggattgga cttggcgcat tttgttcctt gttgctgccg ctactggcgc ccattttcag       60

gtgcagttgg tccagtctgg gggtgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgc attgggtgag acaagcccct      180

ggacaaggcc tggagtggat tggagttatc cgaaccttta gtgggggtgt tacttacaac      240

cagaagttcc cgggaagggg ttccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  872
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  872
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttcc aggaaagggt taccatgacg gtggacaaga gcatttccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  873
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  873
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgttatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc agggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  874
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  874
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtgggggtgt tacttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  875
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  875
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtggggatgt tacttacaac      240

cagaagttca agggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  876
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  876
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtggggatgt tacttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  877
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  877
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc agaacctata gtgggggtgt tacttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  878
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  878
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaaccttta gtgggggtct ttcttacaac      240

cagaagttca gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  879
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  879
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc aaaacctata gtgggggagt tacttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  880
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  880
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgtaaaggtt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttca gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgacaca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  881
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  881
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgttatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtggggaagt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  882
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  882
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc caaaccttta gtggggatgt ttcttacaac      240

cagaagttca agggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  883
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  883
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc cgaacctata gtgggggagt tacttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  884
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  884
atggattgga cttggcgcat tctgttcctt gctgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgtcatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttca gggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  885
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  885
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggatgt tacttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  886
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  886
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaacctata gtggggatgt tacttacaac      240

cagaagttca aggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  887
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  887
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc caaacctata gtgggggtct ttcttacaac      240

cagaagttcc gggaaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  888
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  888
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgttatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttcc gggatagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  889
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  889
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaaccttta gtgggggtgt tacttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  890
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  890
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc aggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctgcgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggccaggga acactcgtca cagtttcgag c               411


<210>  891
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  891
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgtcatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggaattatc aaaacctata gtgggggagt ttcttacaac      240

cagaagttcc agggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  892
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  892
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaaccttta gtggggatct ttcttacaac      240

cagaagttcc ggggaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  893
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  893
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc aaaacctata gtgggggagt tacttacaac      240

cagaagttca aggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gagctgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  894
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  894
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgttatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc agggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  895
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  895
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaaccttta gtgggggagt tacttacaac      240

cagaagttca agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  896
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  896
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaaccttta gtggggatgt ttcttacaac      240

cagaagttcc gggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  897
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  897
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgttatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc caaacctata gtgggggact ttcttacaac      240

cagaagttca ggggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  898
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  898
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaacctata gtgggggtgt tacttacaac      240

cagaagttcc agggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  899
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  899
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctggggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtggggatgt ttcttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  900
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  900
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc caaacctata gtggggatgt ttcttacaac      240

cagaagttca ggggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  901
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  901
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc aaaacctata gtgggggtgt tacttacaac      240

cagaagttcc gggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgagg cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcgggga acactcgtca cagtttcgag c               411


<210>  902
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  902
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaacctata gtgggggtgt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gtatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  903
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  903
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttca agggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  904
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  904
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc gggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  905
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  905
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gtatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgatgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  906
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  906
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  907
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  907
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtggggaagt ttcttacaac      240

cagaagttcc aggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  908
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  908
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgtcatgc attgggtgag gcaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  909
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  909
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtggggatgt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggttacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  910
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  910
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaaccttta gtggggatgt tacttacaac      240

cagaagttcc ggggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  911
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  911
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaacctata gtggggatgt ttcttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  912
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  912
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggtgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtgggggtgt tacttacaac      240

cagaagttca aggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  913
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  913
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc gggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  914
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  914
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgttatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaacctata gtgggggagt ttcttacaac      240

cagaagttca gggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  915
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  915
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtgggggtct ttcttacaac      240

cagaagttca ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcccattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  916
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  916
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaacctata gtgggggagt tacttacaac      240

cagaagttcc agggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  917
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  917
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc agaacctata gtgggggagt tacttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acattcgtca cagtttcgag c               411


<210>  918
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  918
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggagttatc cgaaccttta gtggggatct ttcttacaac      240

cagaagttca agggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  919
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  919
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaacctata gtggggaagt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  920
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  920
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaaccttta gtggggatgt tacttacaac      240

cagaagttcc aggatagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  921
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  921
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaacctata gtggggatgt ttcttacaac      240

cagaagttca ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  922
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  922
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ctattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt ggaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttca ggggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  923
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  923
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtggggatgt tacttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  924
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  924
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc cgaacctata gtggggatct ttcttacaac      240

cagaagttca aggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  925
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  925
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaacctata gtgggggagt ttcttacaac      240

cagaagttcc aggaaagggc taccatgacg gtggacacga gcatttccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcttattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  926
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  926
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc agaacctata gtggggaagt ttcttacaac      240

cagaagttcc agggtagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  927
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  927
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtgggggtgt tacttacaac      240

cagaagttcc agggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacaaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  928
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  928
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc caaacctata gtggggatgt ttcttacaac      240

cagaagttcc agggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  929
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  929
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaacctata gtggggatct ttcttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  930
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  930
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaacctata gtgggggtgt ttcttacaac      240

cagaagttcc aggaaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  931
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  931
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc aaaacctata gtggggatgt ttcttacaac      240

cagaagttca gggaaagggt taccatgacg gtggacaaga acatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  932
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  932
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttca agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  933
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  933
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat tggagttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc aggatagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  934
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  934
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaaccttta gtgggggact tacttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  935
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  935
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaaccttta gtgggggtgt tacttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acattcgtca cagtttcgag c               411


<210>  936
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  936
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcggttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaaccttta gtggggatgt tacttacaac      240

cagaagttca aggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  937
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  937
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacctg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgccatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaacctata gtgggggagt ttcttacaac      240

cagaagttca gggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  938
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  938
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaacctttg gtggggatgt tacttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  939
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  939
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtgggggtgt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acattcgtca cagtttcgag c               411


<210>  940
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  940
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaacctata gtgggggtct tacttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  941
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  941
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc agaaccttta gtgggggtct ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaagga acactcgtca cagtttcgag c               411


<210>  942
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  942
atggattgga cttggcgcat tctgttcctt gttgctgccg ctaccggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaaccttta gtgggggtct ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  943
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  943
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgga tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaaccttta gtgggggagt ttcttacaac      240

cagaagttcc aggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  944
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  944
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgccatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc cgaaccttta gtggggatct ttcttacaac      240

cagaagttca ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  945
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  945
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgc attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaaccttta gtgggggagt ttcttacaac      240

cagaagttcc agggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  946
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  946
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat cggacttatc cgaacctata gtgggggagt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  947
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  947
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgc attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaaccttta gtgggggagt ttcttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  948
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  948
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaacctata gtgggggagt ttcttacaac      240

cagaagttca gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  949
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  949
atggattgga cttggcgcat tctgttcctt gttgctgccg ttactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaacctata gtggggatgt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  950
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  950
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaaccttta gtgggggagt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  951
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  951
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtgggggagt ttcttacaac      240

cagaagttca agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  952
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  952
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtggggatgt ttcttacaac      240

cagaagttcc aggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  953
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  953
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcac ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccggt tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc gggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgctaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  954
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  954
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggacttatc agaacctata gtggggaagt tacttacaac      240

cagaagttca gggaaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  955
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  955
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaaccttta gtgggggagt tacttacaac      240

cagaagttcc ggggtagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  956
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  956
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggaagt ttcttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  957
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  957
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  958
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  958
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc cgaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  959
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  959
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggtgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc aaaaccttta gtgggggtgt tacttacaac      240

cagaagttcc gggggagggt taccatgaca gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  960
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  960
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgga tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc agaaccttta gtggggatgt tacttacaac      240

cagaagttcc gggaaagggc taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  961
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  961
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaaccttta gtggggatgt ttcttacaac      240

cagaagttca agggaagggc taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcatattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  962
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  962
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  963
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  963
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc aaaaccttta gtgggggagt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcccattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  964
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  964
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  965
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  965
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaacctata gtggggaagt ttcttacaac      240

cagaagttcc ggggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  966
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  966
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc caaaccttta gtgggggtct tacttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactaagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  967
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  967
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc aaaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  968
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  968
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg gactgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggacttatc cgaaccttta gtggggatgt tacttacaac      240

cagaagttcc ggggaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  969
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  969
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggacttatc cgaacctata gtggggatgt ttcttacaac      240

cagaagttca gggatagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  970
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  970
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaaccttta gtgggggtgt ttcttacaac      240

cagaagttcc ggggtagggt tatcatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  971
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  971
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc cgaacctata gtggggatgt tacttacaac      240

cagaagttcc aggaaagggt taccatgacg gtggacaaga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  972
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  972
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgat tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat cggagttatc agaacctata gtggggaagt ttcttacaac      240

cagaagttcc agggtagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  973
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  973
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaagctt cagggtacac ctttaccgaa tatgccatgt attgggtgag acaagcacct      180

ggacaaggca tggagtggat gggagttatc cgaacctata gtgggaatgt ttcttacaac      240

cagaagttca agggaagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcaggga acactcgtca cagtttcgag c               411


<210>  974
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VH regions from germlined variants

<400>  974
atggattgga cttggcgcat tctgttcctt gttgctgccg ctactggcgc ccattctcag       60

gtgcagttgg tccagtctgg ggctgaggtg aagaaacccg gtgcttcggt gaaagtgtcc      120

tgcaaaggtt cagggtacac ctttaccgaa tatgctatgt attgggtgag acaagcacct      180

ggacaaggct tggagtggat gggagttatc agaacctata gtggggatgt ttcttacaac      240

cagaagttcc aggatagggt taccatgacg gtggacacga gcatctccac tgcctacatg      300

gaactgagtc ggctacgaag cgacgataca gcggtatact actgtgccaa aagcggcact      360

gtacgtggct ttgcctattg gggtcgggga acactcgtca cagtttcgag c               411


<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1000
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1001
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1001
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1002
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1002
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1003
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1003
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagtgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1004
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1004
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgctc ctggcgaaag agcgaccatc      120

aactgcaagt cctctcaaag cctgctgaat agtagtaatc agaagaacta cctcacttgg      180

tatcatcaga aaccaggaca acctcccaaa ttgctcatct actgggcttc tacacgggaa      240

tcaggtgtac cggataggtt cactggaagt ggatctggca cagactttac gctgacaatc      300

agttccgttc aggcagagga tgttgccgtc tactattgtc agaacgaata ctcatttccc      360

tatacctttg ggcaagggac caagttggag attaag                                396


<210>  1005
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1005
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1006
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1006
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1007
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1007
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ctctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1008
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1008
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1009
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1009
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1010
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1010
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgacg      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1011
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1011
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1012
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1012
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1013
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1013
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1014
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1014
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1015
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1015
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1016
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1016
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1017
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1017
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgtcgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1018
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1018
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1019
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1019
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1020
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1020
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1021
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1021
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctcc tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1022
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1022
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1023
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1023
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1024
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1024
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga tcactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1025
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1025
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatct      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1026
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1026
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1027
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1027
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1028
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1028
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1029
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1029
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1030
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1030
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1031
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1031
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1032
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1032
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1033
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1033
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1034
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1034
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1035
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1035
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1036
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1036
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag cactgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1037
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1037
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1038
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1038
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggaaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1039
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1039
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1040
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1040
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1041
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1041
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagtgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1042
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1042
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgtctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttctg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1043
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1043
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1044
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1044
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1045
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1045
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gatatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1046
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1046
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1047
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1047
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1048
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1048
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1049
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1049
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1050
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1050
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1051
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1051
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1052
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1052
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1053
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1053
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1054
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1054
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1055
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1055
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatct      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1056
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1056
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1057
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1057
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1058
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1058
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1059
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1059
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1060
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1060
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1061
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1061
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1062
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1062
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgacg      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1063
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1063
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagtgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1064
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1064
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1065
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1065
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1066
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1066
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1067
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1067
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1068
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1068
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1069
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1069
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1070
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1070
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1071
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1071
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttgcctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagtttcg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1072
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1072
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1073
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1073
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1074
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1074
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1075
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1075
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1076
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1076
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggacag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1077
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1077
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1078
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1078
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc acattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1079
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1079
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1080
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1080
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtcc ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1081
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1081
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1082
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1082
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1083
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1083
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1084
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1084
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1085
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1085
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1086
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1086
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1087
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1087
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttctg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1088
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1088
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcacc      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ctctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1089
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1089
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1090
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1090
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1091
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1091
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttgtctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1092
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1092
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1093
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1093
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggtga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1094
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1094
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1095
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1095
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1096
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1096
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acagcctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1097
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1097
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaagccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctccgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1098
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1098
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1099
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1099
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1100
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1100
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatct      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1101
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1101
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1102
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1102
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacaaactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1103
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1103
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1104
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1104
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1105
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1105
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1106
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1106
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1107
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1107
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1108
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1108
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1109
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1109
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgactcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1110
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1110
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaaatgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatct      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1111
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1111
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1112
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1112
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1113
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1113
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatct      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1114
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1114
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccc ttcaggcaga ggatgttgcc gtctactatt gtcagaacga atactcattt      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1115
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1115
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttcct ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga atactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1116
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1116
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcaac agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1117
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1117
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtagta atcagaagaa ctacctcact      180

tggtatcaac agaaaccagg acaacctccc aaatcgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttctctgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctaccatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


<210>  1118
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Additional VK regions from germlined variants

<400>  1118
atggtgttac agactcaggt gttcatctcc cttctgctct ggattagcgg tgcctatggc       60

gacatagtga tgactcagag ccctgattcg ttggctgtct ctcttggcga aagagcgacc      120

atcaactgca agtcctctca aagcctgctg aatagtggta atcagaagaa ctacctctct      180

tggtatcatc agaaaccagg acaacctccc aaattgctca tctactgggc ttctacacgg      240

gaatcaggtg taccggatag gttcactgga agtggatctg gcacagactt tacgctgaca      300

atcagttccg ttcaggcaga ggatgttgcc gtctactatt gtcagaacga ttactcatat      360

ccctatacct ttgggcaagg gaccaagttg gagattaag                             399


