                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> INHIBITORS OF FIBROPROLIFERATIVE DISORDERS AND CANCER

<130> 701586-081802-PCT

<140> PCT/US2015/032658
<141> 2015-05-27

<150> 62/051,503
<151> 2014-09-17

<150> 62/003,288
<151> 2014-05-27

<160> 62    

<170> PatentIn version 3.5

<210> 1
<211> 1158
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu 
        35                  40                  45              


Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro 
    50                  55                  60                  


Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly 
65                  70                  75                  80  


Thr Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys 
                85                  90                  95      


Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 
            100                 105                 110         


Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr 
        115                 120                 125             


Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu 
    130                 135                 140                 


Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser 
                165                 170                 175     


Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 
            180                 185                 190         


Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn 
        195                 200                 205             


Pro Gly Glu Glu Thr His Val Glu Ala Arg Glu His Gln Pro Glu Pro 
    210                 215                 220                 


Glu Glu Glu Thr Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu 
225                 230                 235                 240 


Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 
                245                 250                 255     


Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 
            260                 265                 270         


Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu 
        275                 280                 285             


Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp 
    290                 295                 300                 


Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro 
305                 310                 315                 320 


Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys 
                325                 330                 335     


Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu 
            340                 345                 350         


Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg 
        355                 360                 365             


Lys Gly Glu Glu Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Lys 
    370                 375                 380                 


Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
385                 390                 395                 400 


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
                405                 410                 415     


Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
            420                 425                 430         


Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 
        435                 440                 445             


Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 
    450                 455                 460                 


Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 
465                 470                 475                 480 


Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr 
                485                 490                 495     


Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro 
            500                 505                 510         


Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn 
        515                 520                 525             


Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro 
    530                 535                 540                 


Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp Asp Leu 
545                 550                 555                 560 


Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
                565                 570                 575     


Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys 
            580                 585                 590         


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        595                 600                 605             


Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala Gly Ile 
    610                 615                 620                 


His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln 
625                 630                 635                 640 


Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu 
                645                 650                 655     


Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly 
            660                 665                 670         


Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu 
        675                 680                 685             


Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp 
    690                 695                 700                 


Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr 
705                 710                 715                 720 


Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro 
                725                 730                 735     


Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp Met Glu 
            740                 745                 750         


Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu 
        755                 760                 765             


Val Ser Tyr Pro Tyr Asp Met Ala Arg Thr Pro Thr Gln Glu Gln Leu 
    770                 775                 780                 


Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val 
785                 790                 795                 800 


Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp Leu Ala 
                805                 810                 815     


Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr Arg Gly 
            820                 825                 830         


Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val Asn Gly 
        835                 840                 845             


Ala Lys Trp Asn Pro Arg Thr Gly Thr Ile Asn Asp Phe Ser Tyr Leu 
    850                 855                 860                 


His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe 
865                 870                 875                 880 


Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala 
                885                 890                 895     


Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val 
            900                 905                 910         


Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser Val Ser 
        915                 920                 925             


Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr Trp Arg 
    930                 935                 940                 


Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu Gly Tyr 
945                 950                 955                 960 


Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly Ala Thr 
                965                 970                 975     


Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu 
            980                 985                 990         


Ile Met Ala Met Asn Gly Asn Arg  Pro Ile Pro His Ile  Asp Pro Ser 
        995                 1000                 1005             


Arg Pro  Met Thr Pro Gln Gln  Arg Arg Leu Gln Gln  Arg Arg Leu 
    1010                 1015                 1020             


Gln His  Arg Leu Arg Leu Arg  Ala Gln Met Arg Leu  Arg Arg Leu 
    1025                 1030                 1035             


Asn Ala  Thr Thr Thr Leu Gly  Pro His Thr Val Pro  Pro Thr Leu 
    1040                 1045                 1050             


Pro Pro  Ala Pro Ala Thr Thr  Leu Ser Thr Thr Ile  Glu Pro Trp 
    1055                 1060                 1065             


Gly Leu  Ile Pro Pro Thr Thr  Ala Gly Trp Glu Glu  Ser Glu Thr 
    1070                 1075                 1080             


Glu Thr  Tyr Thr Glu Val Val  Thr Glu Phe Gly Thr  Glu Val Glu 
    1085                 1090                 1095             


Pro Glu  Phe Gly Thr Lys Val  Glu Pro Glu Phe Glu  Thr Gln Leu 
    1100                 1105                 1110             


Glu Pro  Glu Phe Glu Thr Gln  Leu Glu Pro Glu Phe  Glu Glu Glu 
    1115                 1120                 1125             


Glu Glu  Glu Glu Lys Glu Glu  Glu Ile Ala Thr Gly  Gln Ala Phe 
    1130                 1135                 1140             


Pro Phe  Thr Thr Val Glu Thr  Tyr Thr Val Asn Phe  Gly Asp Phe 
    1145                 1150                 1155             


<210> 2
<211> 4102
<212> DNA
<213> Homo sapiens

<400> 2
cggctatccg cgcgggagtg cgccacgcgg ggccggagcg cctattagcc gccaggacct       60

cggagcgccc cgaccacccc tgagcccctc tggcttcgga gccccccagc accccttccc      120

gggtcccctc gcccacccta atccactctc cctccctttc ccggattccc tcgctcaccc      180

catcctctct cccgcccctt cctggattcc ctcacccgtc tcgatcccct ctccgccctt      240

tcccagagac ccagagcccc tgaccccccg cgccctcccc ggagcccccc gcgcgtgccg      300

cggccatggc ggccgtgcgc ggggcgcccc tgctcagctg cctcctggcg ttgctggccc      360

tgtgccctgg agggcgcccg cagacggtgc tgaccgacga cgagatcgag gagttcctcg      420

agggcttcct gtcagagcta gaacctgagc cccgggagga cgacgtggag gccccgccgc      480

ctcccgagcc caccccgcgg gtccgaaaag cccaggcggg gggcaagcca gggaagcggc      540

cagggacggc cgcagaagtg cctccggaaa agaccaaaga caaagggaag aaaggcaaga      600

aagacaaagg ccccaaggtg cccaaggagt ccttggaggg gtcccccagg ccgcccaaga      660

aggggaagga gaagccaccc aaggccacca agaagcccaa ggagaagcca cctaaggcca      720

ccaagaagcc caaggagaag ccacccaagg ccaccaagaa gcccaaagag aagccaccca      780

aggccaccaa gaagcccccg tcagggaaga ggccccccat tctggctccc tcagaaaccc      840

tggagtggcc actgccccca ccccccagcc ctggccccga ggagctaccc caggagggag      900

gggcgcccct ctcaaataac tggcagaatc caggagagga gacccatgtg gaggcacggg      960

agcaccagcc tgagccggag gaggagaccg agcaacccac actggactac aatgaccaga     1020

tcgagaggga ggactatgag gactttgagt acattcggcg ccagaagcaa cccaggccac     1080

ccccaagcag aaggaggagg cccgagcggg tctggccaga gccccctgag gagaaggccc     1140

cggccccagc cccggaggag aggattgagc ctcctgtgaa gcctctgctg cccccgctgc     1200

cccctgacta tggtgatggt tacgtgatcc ccaactacga tgacatggac tattactttg     1260

ggcctcctcc gccccagaag cccgatgctg agcgccagac agacgaagag aaggaggagc     1320

tgaagaaacc caaaaaggag gacagcagcc ccaaggagga gaccgacaag tgggcagtgg     1380

agaagggcaa ggaccacaaa gagccccgaa agggcgagga gttggaggag gagtggacgc     1440

ctacggagaa agtcaagtgt ccccccattg ggatggagtc acaccgtatt gaggacaacc     1500

agatccgagc ctcctccatg ctgcgccacg gcctgggggc acagcgcggc cggctcaaca     1560

tgcagaccgg tgccactgag gacgactact atgatggtgc gtggtgtgcc gaggacgatg     1620

ccaggaccca gtggatagag gtggacacca ggaggactac ccggttcaca ggcgtcatca     1680

cccagggcag agactccagc atccatgacg attttgtgac caccttcttc gtgggcttca     1740

gcaatgacag ccagacatgg gtgatgtaca ccaacggcta tgaggaaatg acctttcatg     1800

ggaacgtgga caaggacaca cccgtgctga gtgagctccc agagccggtg gtggctcgtt     1860

tcatccgcat ctacccactc acctggaatg gcagcctgtg catgcgcctg gaggtgctgg     1920

ggtgctctgt ggcccctgtc tacagctact acgcacagaa tgaggtggtg gccaccgatg     1980

acctggattt ccggcaccac agctacaagg acatgcgcca gctcatgaag gtggtgaacg     2040

aggagtgccc caccatcacc cgcacttaca gcctgggcaa gagctcacga ggcctcaaga     2100

tctatgccat ggagatctca gacaaccctg gggagcatga actgggggag cccgagttcc     2160

gctacactgc tgggatccat ggcaacgagg tgctgggccg agagctgttg ctgctgctca     2220

tgcagtacct gtgccgagag taccgcgatg ggaacccacg tgtgcgcagc ctggtgcagg     2280

acacacgcat ccacctggtg ccctcactga accctgatgg ctacgaggtg gcagcgcaga     2340

tgggctcaga gtttgggaac tgggcgctgg gactgtggac tgaggagggc tttgacatct     2400

ttgaagattt cccggatctc aactctgtgc tctggggagc tgaggagagg aaatgggtcc     2460

cctaccgggt ccccaacaat aacttgccca tccctgaacg ctacctttcg ccagatgcca     2520

cggtatccac ggaggtccgg gccatcattg cctggatgga gaagaacccc ttcgtgctgg     2580

gagcaaatct gaacggcggc gagcggctag tatcctaccc ctacgatatg gcccgcacgc     2640

ctacccagga gcagctgctg gccgcagcca tggcagcagc ccggggggag gatgaggacg     2700

aggtctccga ggcccaggag actccagacc acgccatctt ccggtggctt gccatctcct     2760

tcgcctccgc acacctcacc ttgaccgagc cctaccgcgg aggctgccaa gcccaggact     2820

acaccggcgg catgggcatc gtcaacgggg ccaagtggaa cccccggacc gggactatca     2880

atgacttcag ttacctgcat accaactgcc tggagctctc cttctacctg ggctgtgaca     2940

agttccctca tgagagtgag ctgccccgcg agtgggagaa caacaaggag gcgctgctca     3000

ccttcatgga gcaggtgcac cgcggcatta agggggtggt gacggacgag caaggcatcc     3060

ccattgccaa cgccaccatc tctgtgagtg gcattaatca cggcgtgaag acagccagtg     3120

gtggtgatta ctggcgaatc ttgaacccgg gtgagtaccg cgtgacagcc cacgcggagg     3180

gctacacccc gagcgccaag acctgcaatg ttgactatga catcggggcc actcagtgca     3240

acttcatcct ggctcgctcc aactggaagc gcatccggga gatcatggcc atgaacggga     3300

accggcctat cccacacata gacccatcgc gccctatgac cccccaacag cgacgcctgc     3360

agcagcgacg cctacaacac cgcctgcggc ttcgggcaca gatgcggctg cggcgcctca     3420

acgccaccac caccctaggc ccccacactg tgcctcccac gctgccccct gcccctgcca     3480

ccaccctgag cactaccata gagccctggg gcctcatacc gccaaccacc gctggctggg     3540

aggagtcgga gactgagacc tacacagagg tggtgacaga gtttgggacc gaggtggagc     3600

ccgagtttgg gaccaaggtg gagcccgagt ttgagaccca gttggagcct gagtttgaga     3660

cccagctgga acccgagttt gaggaagagg aggaggagga gaaagaggag gagatagcca     3720

ctggccaggc attccccttc acaacagtag agacctacac agtgaacttt ggggacttct     3780

gagatcagcg tcctaccaag accccagccc aactcaagct acagcagcag cacttcccaa     3840

gcctgctgac cacagtcaca tcacccatca gcacatggaa ggcccctggt atggacactg     3900

aaaggaaggg ctggtcctgc ccctttgagg gggtgcaaac atgactggga cctaagagcc     3960

agaggctgtg tagaggctcc tgctccacct gccagtctcg taagagatgg ggttgctgca     4020

gtgttggagt aggggcagag ggagggagcc aaggtcactc caataaaaca agctcatggc     4080

acggacaaaa aaaaaaaaaa aa                                              4102


<210> 3
<211> 11
<212> PRT
<213> Homo sapiens

<400> 3
Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro 
1               5                   10      


<210> 4
<211> 44
<212> PRT
<213> Homo sapiens

<400> 4
Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro 
1               5                   10                  15      


Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys 
            20                  25                  30          


Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro 
        35                  40                  


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Lys Glu Lys Pro Pro Lys Ala Thr Lys Arg Pro 
1               5                   10      


<210> 6
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys 
1               5                   10                  15      


Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys 
            20                  25                  30          


Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
        35                  40                  


<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ggcucaagau cuacgcaau                                                    19


<210> 8
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys 
1               5                   10                  15      


Glu Lys Pro Pro Lys Ala 
            20          


<210> 9
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro 
1               5                   10                  15      


Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys 
            20                  25                  30          


Pro Lys Glu Lys Pro Pro Lys Ala Ser Lys Lys 
        35                  40              


<210> 10
<211> 357
<212> PRT
<213> Homo sapiens

<400> 10
Pro Gln Thr Val Leu Thr Asp Asp Glu Ile Glu Glu Phe Leu Glu Gly 
1               5                   10                  15      


Phe Leu Ser Glu Leu Glu Pro Glu Pro Arg Glu Asp Asp Val Glu Ala 
            20                  25                  30          


Pro Pro Pro Pro Glu Pro Thr Pro Arg Val Arg Lys Ala Gln Gly Gly 
        35                  40                  45              


Lys Pro Gly Lys Arg Pro Gly Thr Ala Ala Glu Val Pro Pro Glu Lys 
    50                  55                  60                  


Thr Lys Asp Lys Gly Lys Lys Gly Lys Lys Asp Lys Gly Pro Lys Val 
65                  70                  75                  80  


Pro Lys Glu Ser Leu Glu Gly Ser Pro Arg Pro Pro Lys Lys Gly Lys 
                85                  90                  95      


Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys 
            100                 105                 110         


Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro 
        115                 120                 125             


Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Pro Ser Gly Lys Arg 
    130                 135                 140                 


Pro Pro Ile Leu Ala Pro Ser Glu Thr Leu Glu Trp Pro Leu Pro Pro 
145                 150                 155                 160 


Pro Pro Ser Pro Gly Pro Glu Glu Leu Pro Gln Glu Gly Gly Ala Pro 
                165                 170                 175     


Leu Ser Asn Asn Trp Gln Asn Pro Gly Glu Glu Thr His Val Glu Ala 
            180                 185                 190         


Arg Glu His Gln Pro Glu Pro Glu Glu Glu Thr Glu Gln Pro Thr Leu 
        195                 200                 205             


Asp Tyr Asn Asp Gln Ile Glu Arg Glu Asp Tyr Glu Asp Phe Glu Tyr 
    210                 215                 220                 


Ile Arg Arg Gln Lys Gln Pro Arg Pro Pro Pro Ser Arg Arg Arg Arg 
225                 230                 235                 240 


Pro Glu Arg Val Trp Pro Glu Pro Pro Glu Glu Lys Ala Pro Ala Pro 
                245                 250                 255     


Ala Pro Glu Glu Arg Ile Glu Pro Pro Val Lys Pro Leu Leu Pro Pro 
            260                 265                 270         


Leu Pro Pro Asp Tyr Gly Asp Gly Tyr Val Ile Pro Asn Tyr Asp Asp 
        275                 280                 285             


Met Asp Tyr Tyr Phe Gly Pro Pro Pro Pro Gln Lys Pro Asp Ala Glu 
    290                 295                 300                 


Arg Gln Thr Asp Glu Glu Lys Glu Glu Leu Lys Lys Pro Lys Lys Glu 
305                 310                 315                 320 


Asp Ser Ser Pro Lys Glu Glu Thr Asp Lys Trp Ala Val Glu Lys Gly 
                325                 330                 335     


Lys Asp His Lys Glu Pro Arg Lys Gly Glu Glu Leu Glu Glu Glu Trp 
            340                 345                 350         


Thr Pro Thr Glu Lys 
        355         


<210> 11
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
1               5                   10                  15      


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
            20                  25                  30          


Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
        35                  40                  45              


Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 
    50                  55                  60                  


Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 
65                  70                  75                  80  


Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 
                85                  90                  95      


Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr 
            100                 105                 110         


Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro 
        115                 120                 125             


Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn 
    130                 135                 140                 


Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys 
145                 150                 155     


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Met Leu Arg His Gly Leu Gly 
1               5           


<210> 13
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
1               5                   10              


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asp Ala Arg Thr Gln 
1               5   


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Arg Asp Ser Ser Ile His Asp Asp 
1               5               


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Met Leu Arg His Gly Leu Gly Ala 
1               5               


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Met Leu Arg His Gly Leu Gly Ala Gln 
1               5                   


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ser Met Leu Arg His Gly Leu Gly 
1               5               


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ser Ser Met Leu Arg His Gly Leu Gly 
1               5               


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Met Leu Arg His Gly Leu Gly Ala 
1               5                   


<210> 21
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ser Met Leu Arg His Gly Leu Gly Ala Gln 
1               5                   10  


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ser Ser Met Leu Arg His Gly Leu Gly Ala 
1               5                   10  


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln 
1               5                   10      


<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala Trp 
1               5                   10                  


<210> 25
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala Trp Cys 
1               5                   10                  15  


<210> 26
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
1               5                   10                  


<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
1               5                   10                  15  


<210> 28
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala Trp 
1               5                   10                  15  


<210> 29
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala Trp Cys 
1               5                   10                  15      


<210> 30
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala Trp 
1               5                   10                  15      


<210> 31
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala Trp 
1               5                   10                  15      


Cys 
    


<210> 32
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Asp Ala Arg Thr Gln Trp 
1               5       


<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Asp Ala Arg Thr Gln Trp Ile 
1               5           


<210> 34
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Asp Asp Ala Arg Thr Gln 
1               5       


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Glu Asp Asp Ala Arg Thr Gln 
1               5           


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Asp Asp Ala Arg Thr Gln Trp 
1               5           


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Asp Asp Ala Arg Thr Gln Trp Ile 
1               5               


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Glu Asp Asp Ala Arg Thr Gln Trp 
1               5               


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Glu Asp Asp Ala Arg Thr Gln Trp Ile 
1               5                   


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Arg Asp Ser Ser Ile His Asp Asp Phe 
1               5                   


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Arg Asp Ser Ser Ile His Asp Asp Phe Val 
1               5                   10  


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Arg Asp Ser Ser Ile His Asp Asp 
1               5                   


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gln Gly Arg Asp Ser Ser Ile His Asp Asp 
1               5                   10  


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Arg Asp Ser Ser Ile His Asp Asp Phe 
1               5                   10  


<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gly Arg Asp Ser Ser Ile His Asp Asp Phe Val 
1               5                   10      


<210> 46
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gln Gly Arg Asp Ser Ser Ile His Asp Asp Phe 
1               5                   10      


<210> 47
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gln Gly Arg Asp Ser Ser Ile His Asp Asp Phe Val 
1               5                   10          


<210> 48
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Leu Glu Leu Val Pro Arg Gly Ser Gly Asp Pro Ile Glu Gly Arg Gly 
1               5                   10                  15      


Gly Gly Gly Gly Asp Pro Lys Ser Cys Asp Lys Pro His Thr Cys Pro 
            20                  25                  30          


Leu Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210> 49
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
1               5                   10      


<210> 50
<211> 1170
<212> PRT
<213> Macaca fascicularis 

<400> 50
Met Ala Ala Val Arg Gly Ala Pro Leu Leu Gly Cys Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Gly Pro Glu 
        35                  40                  45              


Pro Arg Glu Asp Asp Met Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro 
    50                  55                  60                  


Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys 
                85                  90                  95      


Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 
            100                 105                 110         


Ser Pro Lys Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr 
        115                 120                 125             


Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu 
    130                 135                 140                 


Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Thr Leu Ala Pro Ser 
                165                 170                 175     


Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 
            180                 185                 190         


Glu Leu Pro Gln Glu Gly Gly Gly Pro Leu Pro Asn Asn Trp Gln Asn 
        195                 200                 205             


Pro Gly Glu Glu Thr Arg Val Glu Ala Arg Glu His Gln Pro Glu Pro 
    210                 215                 220                 


Glu Glu Glu Thr Glu Leu Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu 
225                 230                 235                 240 


Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 
                245                 250                 255     


Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 
            260                 265                 270         


Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Ala Pro Glu Glu Arg 
        275                 280                 285             


Ile Glu Pro Pro Val Lys Pro Leu Leu Pro Leu Leu Pro Pro Asp Tyr 
    290                 295                 300                 


Gly Asp Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe 
305                 310                 315                 320 


Gly Pro Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu 
                325                 330                 335     


Glu Lys Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Gly Arg Pro Lys 
            340                 345                 350         


Glu Glu Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu 
        355                 360                 365             


Pro Arg Lys Gly Glu Glu Val Glu Glu Glu Trp Thr Pro Thr Glu Lys 
    370                 375                 380                 


Val Lys Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn 
385                 390                 395                 400 


Gln Ile Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg 
                405                 410                 415     


Gly Arg Leu Asn Met Gln Ala Gly Ala Thr Glu Asp Asp Tyr Tyr Asp 
            420                 425                 430         


Gly Ala Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val 
        435                 440                 445             


Asp Thr Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg 
    450                 455                 460                 


Asp Ser Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe 
465                 470                 475                 480 


Ser Asn Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu 
                485                 490                 495     


Met Thr Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu 
            500                 505                 510         


Leu Pro Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr 
        515                 520                 525             


Trp Asn Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Pro Val 
    530                 535                 540                 


Ala Pro Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp 
545                 550                 555                 560 


Asp Leu Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met 
                565                 570                 575     


Lys Val Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu 
            580                 585                 590         


Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp 
        595                 600                 605             


Asn Pro Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala 
    610                 615                 620                 


Gly Ile His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu 
625                 630                 635                 640 


Met Gln Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg 
                645                 650                 655     


Ser Leu Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro 
            660                 665                 670         


Asp Gly Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp 
        675                 680                 685             


Ala Leu Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe 
    690                 695                 700                 


Pro Asp Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val 
705                 710                 715                 720 


Pro Tyr Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu 
                725                 730                 735     


Ser Pro Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp 
            740                 745                 750         


Met Glu Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu 
        755                 760                 765             


Arg Leu Val Ser Tyr Pro Tyr Asp Met Thr Arg Thr Pro Thr Gln Glu 
    770                 775                 780                 


Gln Leu Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp 
785                 790                 795                 800 


Glu Val Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp 
                805                 810                 815     


Leu Ala Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr 
            820                 825                 830         


Arg Gly Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val 
        835                 840                 845             


Asn Gly Ala Lys Trp Asn Pro Arg Ser Gly Thr Ile Asn Asp Phe Ser 
    850                 855                 860                 


Tyr Leu His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp 
865                 870                 875                 880 


Lys Phe Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys 
                885                 890                 895     


Glu Ala Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly 
            900                 905                 910         


Val Val Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser 
        915                 920                 925             


Val Ser Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr 
    930                 935                 940                 


Trp Arg Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu 
945                 950                 955                 960 


Gly Tyr Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly 
                965                 970                 975     


Ala Thr Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile 
            980                 985                 990         


Arg Glu Ile Met Ala Met Asn Gly  Asn Arg Pro Ile Pro  His Ile Asp 
        995                 1000                 1005             


Pro Ser  Arg Pro Met Thr Pro  Gln Gln Arg Arg Leu  Gln Gln Arg 
    1010                 1015                 1020             


Arg Leu  Gln His Arg Leu Arg  Leu Arg Ala Gln Met  Arg Leu Arg 
    1025                 1030                 1035             


Arg Leu  Asn Ala Thr Thr Thr  Leu Gly Pro His Thr  Val Pro Ser 
    1040                 1045                 1050             


Thr Leu  Pro Pro Ala Pro Ala  Thr Thr Leu Ser Thr  Thr Ile Glu 
    1055                 1060                 1065             


Pro Trp  Gly Leu Val Pro Pro  Thr Thr Ala Gly Trp  Glu Glu Ser 
    1070                 1075                 1080             


Glu Thr  Glu Thr Tyr Thr Glu  Val Val Thr Glu Phe  Gly Thr Glu 
    1085                 1090                 1095             


Val Glu  Pro Glu Phe Gly Thr  Lys Val Glu Pro Glu  Phe Glu Thr 
    1100                 1105                 1110             


Gln Leu  Glu Thr Glu Phe Glu  Thr Gln Leu Glu Pro  Glu Phe Glu 
    1115                 1120                 1125             


Thr Gln  Leu Glu Pro Glu Phe  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1130                 1135                 1140             


Glu Glu  Glu Glu Glu Ile Ala  Thr Gly Gln Ala Phe  Pro Phe Thr 
    1145                 1150                 1155             


Thr Val  Glu Thr Tyr Thr Val  Asn Phe Gly Asp Phe  
    1160                 1165                 1170 


<210> 51
<211> 1128
<212> PRT
<213> Rattus norvegicus 

<400> 51
Met Ala Ala Val Arg Thr Ala Ser Leu Leu Cys Gly Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Glu Gly Ser Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Gln Glu Phe Leu Glu Gly Phe Leu Ser Glu Phe Glu Thr Gln 
        35                  40                  45              


Ser Pro Pro Arg Glu Asp Asp Val Glu Ala Gln Pro Leu Pro Glu Pro 
    50                  55                  60                  


Thr Gln Arg Ala Arg Lys Ser Lys Ala Gly Gly Lys Pro Arg Ala Asp 
65                  70                  75                  80  


Ala Glu Ala Pro Pro Glu Lys Asn Lys Asp Lys Glu Lys Lys Gly Lys 
                85                  90                  95      


Lys Asp Lys Gly Pro Lys Ala Ala Lys His Leu Glu Gly Ser Thr Arg 
            100                 105                 110         


Pro Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro 
        115                 120                 125             


Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro 
    130                 135                 140                 


Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Arg 
145                 150                 155                 160 


Pro Ser Ala Gly Lys Arg Phe Ser Thr Val Ala Pro Leu Glu Thr Pro 
                165                 170                 175     


Glu Arg Ser Leu Thr Ser Pro Ser Asn Pro Gly Thr Arg Glu Leu Pro 
            180                 185                 190         


Glu Glu Arg Gly Arg Thr Ser Leu Asn Thr Trp Gln Gly Gln Gly Glu 
        195                 200                 205             


Glu Thr Gln Val Glu Ala Arg Gln His Arg Pro Glu Pro Glu Glu Glu 
    210                 215                 220                 


Thr Glu Met Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu Arg Glu Asp 
225                 230                 235                 240 


Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro Arg Pro Thr 
                245                 250                 255     


Pro Ser Arg Lys Arg Ile Trp Pro Glu Pro Pro Glu Glu Lys Thr Gln 
            260                 265                 270         


Glu Pro Glu Glu Arg Lys Glu Val Asp Pro Pro Leu Lys Pro Leu Leu 
        275                 280                 285             


Pro Pro Asp Tyr Gly Asp Gly Tyr Leu Ile Pro Asn Tyr Asp Asp Leu 
    290                 295                 300                 


Asp Tyr Tyr Phe Pro His Pro Pro Pro Gln Lys Pro Asp Val Gly Gln 
305                 310                 315                 320 


Glu Val Asp Glu Glu Lys Glu Glu Leu Lys Lys Pro Lys Lys Glu Gly 
                325                 330                 335     


Ser Ser Pro Lys Glu Asp Thr Glu Asp Lys Trp Ala Ala Glu Lys Asn 
            340                 345                 350         


Lys Asp His Lys Ala Gly Pro Arg Lys Gly Glu Glu Leu Glu Glu Glu 
        355                 360                 365             


Trp Gly Pro Val Glu Lys Ile Lys Cys Pro Pro Ile Gly Met Glu Ser 
    370                 375                 380                 


His Arg Ile Glu Asp Asn Gln Ile Arg Ala Ser Ser Met Leu Arg His 
385                 390                 395                 400 


Gly Leu Gly Ala Gln Arg Gly Arg Leu Asn Met Gln Ala Gly Ala Asn 
                405                 410                 415     


Glu Asp Asp Tyr Tyr Asp Gly Ala Trp Cys Ala Glu Asp Glu Ser Gln 
            420                 425                 430         


Thr Gln Trp Ile Glu Val Asp Thr Arg Arg Thr Thr Arg Phe Thr Gly 
        435                 440                 445             


Val Ile Thr Gln Gly Arg Asp Ser Ser Ile His Asp Asp Phe Val Thr 
    450                 455                 460                 


Thr Phe Phe Val Gly Phe Ser Asn Asp Ser Gln Thr Trp Val Met Tyr 
465                 470                 475                 480 


Thr Asn Gly Tyr Glu Glu Met Thr Phe His Gly Asn Val Asp Lys Asp 
                485                 490                 495     


Thr Pro Val Leu Ser Glu Leu Pro Glu Pro Val Val Ala Arg Phe Ile 
            500                 505                 510         


Arg Ile Tyr Pro Leu Thr Trp Asn Gly Ser Leu Cys Met Arg Leu Glu 
        515                 520                 525             


Val Leu Gly Cys Pro Val Thr Pro Val Tyr Ser Tyr Tyr Ala Gln Asn 
    530                 535                 540                 


Glu Val Val Thr Thr Asp Ser Leu Asp Phe Arg His His Ser Tyr Lys 
545                 550                 555                 560 


Asp Met Arg Gln Leu Met Lys Val Val Asn Glu Glu Cys Pro Thr Ile 
                565                 570                 575     


Thr Arg Thr Tyr Ser Leu Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr 
            580                 585                 590         


Ala Met Glu Ile Ser Asp Asn Pro Gly Glu His Glu Leu Gly Glu Pro 
        595                 600                 605             


Glu Phe Arg Tyr Thr Ala Gly Met His Gly Asn Glu Val Leu Gly Arg 
    610                 615                 620                 


Glu Leu Leu Leu Leu Leu Met Gln Tyr Leu Cys His Glu Tyr Arg Asp 
625                 630                 635                 640 


Gly Asn Pro Arg Val Arg Asn Leu Val Gln Asp Thr Arg Ile His Leu 
                645                 650                 655     


Val Pro Ser Leu Asn Pro Asp Gly Tyr Glu Val Ala Ala Gln Met Gly 
            660                 665                 670         


Ser Glu Phe Gly Asn Trp Ala Leu Gly Leu Trp Thr Glu Glu Gly Phe 
        675                 680                 685             


Asp Ile Phe Glu Asp Phe Pro Asp Leu Asn Ser Val Leu Trp Ala Ala 
    690                 695                 700                 


Glu Glu Lys Lys Trp Val Pro Tyr Arg Val Pro Asn Asn Asn Leu Pro 
705                 710                 715                 720 


Ile Pro Glu Arg Tyr Leu Ser Pro Asp Ala Thr Val Ser Thr Glu Val 
                725                 730                 735     


Arg Ala Ile Ile Ser Trp Met Glu Lys Asn Pro Phe Val Leu Gly Ala 
            740                 745                 750         


Asn Leu Asn Gly Gly Glu Arg Leu Val Ser Tyr Pro Tyr Asp Met Ala 
        755                 760                 765             


Arg Thr Pro Ser Gln Glu Gln Leu Leu Ala Ala Ala Leu Ala Ala Ala 
    770                 775                 780                 


Arg Gly Glu Asp Glu Asp Glu Val Ser Glu Ala Gln Glu Thr Pro Asp 
785                 790                 795                 800 


His Ala Ile Phe Arg Trp Leu Ala Ile Ser Phe Ala Ser Ala His Leu 
                805                 810                 815     


Thr Met Thr Glu Pro Tyr Arg Gly Gly Cys Gln Ala Gln Asp Tyr Thr 
            820                 825                 830         


Ser Gly Met Gly Ile Val Asn Gly Ala Lys Trp Asn Pro Arg Ser Gly 
        835                 840                 845             


Thr Phe Asn Asp Phe Ser Tyr Leu His Thr Asn Cys Leu Glu Leu Ser 
    850                 855                 860                 


Ile Tyr Leu Gly Cys Asp Lys Phe Pro His Glu Ser Glu Leu Pro Arg 
865                 870                 875                 880 


Glu Trp Glu Asn Asn Lys Glu Ala Leu Leu Thr Phe Met Glu Gln Val 
                885                 890                 895     


His Arg Gly Ile Lys Gly Val Val Thr Asp Glu Gln Gly Ile Pro Ile 
            900                 905                 910         


Ala Asn Ala Thr Ile Ser Val Ser Gly Ile Asn His Gly Val Lys Thr 
        915                 920                 925             


Ala Ser Gly Gly Asp Tyr Trp Arg Ile Leu Asn Pro Gly Glu Tyr Arg 
    930                 935                 940                 


Val Thr Ala His Ala Glu Gly Tyr Thr Ser Ser Ala Lys Ile Cys Asn 
945                 950                 955                 960 


Val Asp Tyr Asp Ile Gly Ala Thr Gln Cys Asn Phe Ile Leu Ala Arg 
                965                 970                 975     


Ser Asn Trp Lys Arg Ile Arg Glu Ile Leu Ala Met Asn Gly Asn Arg 
            980                 985                 990         


Pro Ile Leu Arg Val Asp Pro Ser  Arg Pro Met Thr Pro  Gln Gln Arg 
        995                 1000                 1005             


Arg Leu  Gln Gln Arg Arg Leu  Arg Tyr Arg Leu Arg  Met Arg Glu 
    1010                 1015                 1020             


Gln Met  Arg Leu Arg Arg Leu  Asn Ser Thr Thr Gly  Pro Ala Thr 
    1025                 1030                 1035             


Ser Pro  Thr Pro Ala Leu Thr  Leu Pro Pro Ser Pro  Thr Pro Gly 
    1040                 1045                 1050             


Ser Thr  Ser Arg Leu Trp Glu  Ile Leu Pro Thr Thr  Ala Ala Gly 
    1055                 1060                 1065             


Trp Glu  Glu Ser Glu Thr Glu  Thr Tyr Thr Glu Val  Val Thr Glu 
    1070                 1075                 1080             


Phe Glu  Thr Glu Tyr Gly Pro  Asp Leu Glu Val Glu  Glu Leu Glu 
    1085                 1090                 1095             


Glu Glu  Glu Glu Glu Glu Glu  Glu Met Asp Thr Gly  Leu Thr Phe 
    1100                 1105                 1110             


Pro Val  Thr Thr Val Glu Thr  Tyr Thr Val Asn Phe  Gly Asp Phe 
    1115                 1120                 1125             


<210> 52
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Cys Arg Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp 
1               5                   10                  15      


Ile Ser Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser 
            20                  25                  30          


Arg Leu Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser 
        35                  40                  45              


Val Phe Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu 
    50                  55                  60                  


His Leu Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu 
65                  70                  75                  80  


Gly Lys Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly 
                85                  90                  95      


Arg Arg Trp Met 
            100 


<210> 53
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Cys Arg Tyr Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp 
1               5                   10                  15      


Ile Thr Ala Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly 
            20                  25                  30          


Arg Leu Asp Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro 
        35                  40                  45              


Val Glu Pro Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr 
    50                  55                  60                  


Leu His Phe Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly 
65                  70                  75                  80  


His Gly Ile Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp 
                85                  90                  95      


Gly Thr Arg Trp Ile 
            100     


<210> 54
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
1               5                   10                  15      


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
            20                  25                  30          


Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
        35                  40                  45              


Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 
    50                  55                  60                  


Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 
65                  70                  75                  80  


Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 
                85                  90                  95      


Asp Ser Gln Thr Trp Val 
            100         


<210> 55
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Cys Ser Thr Pro Leu Gly Met Glu Asn Gly Lys Ile Glu Asn Lys Gln 
1               5                   10                  15      


Ile Thr Ala Ser Ser Phe Lys Lys Ser Trp Trp Gly Asp Tyr Trp Glu 
            20                  25                  30          


Pro Phe Arg Ala Arg Leu Asn Ala Gln Gly Arg Val Asn Ala Trp Gln 
        35                  40                  45              


Ala Lys Ala Asn Asn Asn Lys Gln Trp Leu Glu Ile Asp Leu Leu Lys 
    50                  55                  60                  


Ile Lys Lys Ile Thr Ala Ile Ile Thr Gln Gly Cys Lys Ser Leu Ser 
65                  70                  75                  80  


Ser Glu Met Tyr Val Lys Ser Tyr Thr Ile His Tyr Ser Glu Gln Gly 
                85                  90                  95      


Val Glu Trp Lys 
            100 


<210> 56
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (41)..(41)
<223> Thr or Ser

<400> 56
Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro 
1               5                   10                  15      


Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys 
            20                  25                  30          


Pro Lys Glu Lys Pro Pro Lys Ala Xaa Lys Lys 
        35                  40              


<210> 57
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<400> 57
Lys Glu Lys Pro Pro Lys Ala Xaa Lys Lys Pro Xaa Glu Lys Pro Pro 
1               5                   10                  15      


Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys 
            20                  25                  30          


Pro Lys Xaa Lys Pro Pro Lys Ala Xaa Lys Xaa 
        35                  40              


<210> 58
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
ugguuuacau gucgacuaa                                                    19


<210> 59
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
ugguuuacau guuguguga                                                    19


<210> 60
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
ugguuuacau guuuuccua                                                    19


<210> 61
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
ugguuuacau guuuucuga                                                    19


<210> 62
<211> 1128
<212> PRT
<213> Mus musculus

<400> 62
Met Ala Pro Val Arg Thr Ala Ser Leu Leu Cys Gly Leu Leu Ala Leu 
1               5                   10                  15      


Leu Thr Leu Cys Pro Glu Gly Asn Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Thr Gln 
        35                  40                  45              


Ser Pro Pro Arg Glu Asp Asp Val Glu Val Gln Pro Leu Pro Glu Pro 
    50                  55                  60                  


Thr Gln Arg Pro Arg Lys Ser Lys Ala Gly Gly Lys Gln Arg Ala Asp 
65                  70                  75                  80  


Val Glu Val Pro Pro Glu Lys Asn Lys Asp Lys Glu Lys Lys Gly Lys 
                85                  90                  95      


Lys Asp Lys Gly Pro Lys Ala Thr Lys Pro Leu Glu Gly Ser Thr Arg 
            100                 105                 110         


Pro Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro 
        115                 120                 125             


Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro 
    130                 135                 140                 


Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Arg 
145                 150                 155                 160 


Pro Ser Ala Gly Lys Lys Phe Ser Thr Val Ala Pro Leu Glu Thr Leu 
                165                 170                 175     


Asp Arg Leu Leu Pro Ser Pro Ser Asn Pro Ser Ala Gln Glu Leu Pro 
            180                 185                 190         


Gln Lys Arg Asp Thr Pro Phe Pro Asn Ala Trp Gln Gly Gln Gly Glu 
        195                 200                 205             


Glu Thr Gln Val Glu Ala Lys Gln Pro Arg Pro Glu Pro Glu Glu Glu 
    210                 215                 220                 


Thr Glu Met Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu Lys Glu Asp 
225                 230                 235                 240 


Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro Arg Pro Thr 
                245                 250                 255     


Pro Ser Arg Arg Arg Leu Trp Pro Glu Arg Pro Glu Glu Lys Thr Glu 
            260                 265                 270         


Glu Pro Glu Glu Arg Lys Glu Val Glu Pro Pro Leu Lys Pro Leu Leu 
        275                 280                 285             


Pro Pro Asp Tyr Gly Asp Ser Tyr Val Ile Pro Asn Tyr Asp Asp Leu 
    290                 295                 300                 


Asp Tyr Tyr Phe Pro His Pro Pro Pro Gln Lys Pro Asp Val Gly Gln 
305                 310                 315                 320 


Glu Val Asp Glu Glu Lys Glu Glu Met Lys Lys Pro Lys Lys Glu Gly 
                325                 330                 335     


Ser Ser Pro Lys Glu Asp Thr Glu Asp Lys Trp Thr Val Glu Lys Asn 
            340                 345                 350         


Lys Asp His Lys Gly Pro Arg Lys Gly Glu Glu Leu Glu Glu Glu Trp 
        355                 360                 365             


Ala Pro Val Glu Lys Ile Lys Cys Pro Pro Ile Gly Met Glu Ser His 
    370                 375                 380                 


Arg Ile Glu Asp Asn Gln Ile Arg Ala Ser Ser Met Leu Arg His Gly 
385                 390                 395                 400 


Leu Gly Ala Gln Arg Gly Arg Leu Asn Met Gln Ala Gly Ala Asn Glu 
                405                 410                 415     


Asp Asp Tyr Tyr Asp Gly Ala Trp Cys Ala Glu Asp Glu Ser Gln Thr 
            420                 425                 430         


Gln Trp Ile Glu Val Asp Thr Arg Arg Thr Thr Arg Phe Thr Gly Val 
        435                 440                 445             


Ile Thr Gln Gly Arg Asp Ser Ser Ile His Asp Asp Phe Val Thr Thr 
    450                 455                 460                 


Phe Phe Val Gly Phe Ser Asn Asp Ser Gln Thr Trp Val Met Tyr Thr 
465                 470                 475                 480 


Asn Gly Tyr Glu Glu Met Thr Phe Tyr Gly Asn Val Asp Lys Asp Thr 
                485                 490                 495     


Pro Val Leu Ser Glu Leu Pro Glu Pro Val Val Ala Arg Phe Ile Arg 
            500                 505                 510         


Ile Tyr Pro Leu Thr Trp Asn Gly Ser Leu Cys Met Arg Leu Glu Val 
        515                 520                 525             


Leu Gly Cys Pro Val Thr Pro Val Tyr Ser Tyr Tyr Ala Gln Asn Glu 
    530                 535                 540                 


Val Val Thr Thr Asp Ser Leu Asp Phe Arg His His Ser Tyr Lys Asp 
545                 550                 555                 560 


Met Arg Gln Leu Met Lys Ala Val Asn Glu Glu Cys Pro Thr Ile Thr 
                565                 570                 575     


Arg Thr Tyr Ser Leu Gly Lys Ser Ser Arg Gly Leu Lys Ile Tyr Ala 
            580                 585                 590         


Met Glu Ile Ser Asp Asn Pro Gly Asp His Glu Leu Gly Glu Pro Glu 
        595                 600                 605             


Phe Arg Tyr Thr Ala Gly Ile His Gly Asn Glu Val Leu Gly Arg Glu 
    610                 615                 620                 


Leu Leu Leu Leu Leu Met Gln Tyr Leu Cys Gln Glu Tyr Arg Asp Gly 
625                 630                 635                 640 


Asn Pro Arg Val Arg Asn Leu Val Gln Asp Thr Arg Ile His Leu Val 
                645                 650                 655     


Pro Ser Leu Asn Pro Asp Gly Tyr Glu Val Ala Ala Gln Met Gly Ser 
            660                 665                 670         


Glu Phe Gly Asn Trp Ala Leu Gly Leu Trp Thr Glu Glu Gly Phe Asp 
        675                 680                 685             


Ile Phe Glu Asp Phe Pro Asp Leu Asn Ser Val Leu Trp Ala Ala Glu 
    690                 695                 700                 


Glu Lys Lys Trp Val Pro Tyr Arg Val Pro Asn Asn Asn Leu Pro Ile 
705                 710                 715                 720 


Pro Glu Arg Tyr Leu Ser Pro Asp Ala Thr Val Ser Thr Glu Val Arg 
                725                 730                 735     


Ala Ile Ile Ser Trp Met Glu Lys Asn Pro Phe Val Leu Gly Ala Asn 
            740                 745                 750         


Leu Asn Gly Gly Glu Arg Leu Val Ser Tyr Pro Tyr Asp Met Ala Arg 
        755                 760                 765             


Thr Pro Ser Gln Glu Gln Leu Leu Ala Glu Ala Leu Ala Ala Ala Arg 
    770                 775                 780                 


Gly Glu Asp Asp Asp Gly Val Ser Glu Ala Gln Glu Thr Pro Asp His 
785                 790                 795                 800 


Ala Ile Phe Arg Trp Leu Ala Ile Ser Phe Ala Ser Ala His Leu Thr 
                805                 810                 815     


Met Thr Glu Pro Tyr Arg Gly Gly Cys Gln Ala Gln Asp Tyr Thr Ser 
            820                 825                 830         


Gly Met Gly Ile Val Asn Gly Ala Lys Trp Asn Pro Arg Ser Gly Thr 
        835                 840                 845             


Phe Asn Asp Phe Ser Tyr Leu His Thr Asn Cys Leu Glu Leu Ser Val 
    850                 855                 860                 


Tyr Leu Gly Cys Asp Lys Phe Pro His Glu Ser Glu Leu Pro Arg Glu 
865                 870                 875                 880 


Trp Glu Asn Asn Lys Glu Ala Leu Leu Thr Phe Met Glu Gln Val His 
                885                 890                 895     


Arg Gly Ile Lys Gly Val Val Thr Asp Glu Gln Gly Ile Pro Ile Ala 
            900                 905                 910         


Asn Ala Thr Ile Ser Val Ser Gly Ile Asn His Gly Val Lys Thr Ala 
        915                 920                 925             


Ser Gly Gly Asp Tyr Trp Arg Ile Leu Asn Pro Gly Glu Tyr Arg Val 
    930                 935                 940                 


Thr Ala His Ala Glu Gly Tyr Thr Ser Ser Ala Lys Ile Cys Asn Val 
945                 950                 955                 960 


Asp Tyr Asp Ile Gly Ala Thr Gln Cys Asn Phe Ile Leu Ala Arg Ser 
                965                 970                 975     


Asn Trp Lys Arg Ile Arg Glu Ile Leu Ala Met Asn Gly Asn Arg Pro 
            980                 985                 990         


Ile Leu Arg Val Asp Pro Ser Arg  Pro Met Thr Pro Gln  Gln Arg Arg 
        995                 1000                 1005             


Met Gln  Gln Arg Arg Leu Gln  Tyr Arg Leu Arg Met  Arg Glu Gln 
    1010                 1015                 1020             


Met Arg  Leu Arg Arg Leu Asn  Ser Thr Ala Gly Pro  Ala Thr Ser 
    1025                 1030                 1035             


Pro Thr  Pro Ala Leu Met Pro  Pro Pro Ser Pro Thr  Pro Ala Ile 
    1040                 1045                 1050             


Thr Leu  Arg Pro Trp Glu Val  Leu Pro Thr Thr Thr  Ala Gly Trp 
    1055                 1060                 1065             


Glu Glu  Ser Glu Thr Glu Thr  Tyr Thr Glu Val Val  Thr Glu Phe 
    1070                 1075                 1080             


Glu Thr  Glu Tyr Gly Thr Asp  Leu Glu Val Glu Glu  Ile Glu Glu 
    1085                 1090                 1095             


Glu Glu  Glu Glu Glu Glu Glu  Glu Met Asp Thr Gly  Leu Thr Phe 
    1100                 1105                 1110             


Pro Leu  Thr Thr Val Glu Thr  Tyr Thr Val Asn Phe  Gly Asp Phe 
    1115                 1120                 1125             

