                         SEQUENCE LISTING

<110>  IDT Biologika GmbH
 
<120>  Vaccine composition against Streptococcus suis infection

<130>  P37819-WO

<150>  EP14170637.4
<151>  2014-05-30

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1141
<212>  PRT
<213>  Streptococcus suis

<400>  1

Met Asn Ile Gln Glu Arg Phe Ser Leu Arg Lys Ser Ala Val Gly Leu 
1               5                   10                  15      


Val Ser Val Ser Leu Leu Cys Ala Ile Tyr Thr Ser Thr Val Ala Ala 
            20                  25                  30          


Asp Thr Val Val Thr Gly Val Asn Glu Ile Ile Glu Glu Ser Gln Val 
        35                  40                  45              


Lys Asp Glu Val Ser Ile Glu Ser Glu Lys Asn Glu Ser Leu Asp Gly 
    50                  55                  60                  


Ser Asn Ile Glu Ile Val Glu Glu Ile Ala Asp Asn Ile Pro Ser Pro 
65                  70                  75                  80  


Val Ile Ala Glu Gly Glu Val Ala Val Glu Met Lys Val Asp Arg Gly 
                85                  90                  95      


Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu Val Thr Thr Ser Glu 
            100                 105                 110         


Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu Ile Leu Asn Gln Thr 
        115                 120                 125             


Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln Ile Ile Trp Ala His 
    130                 135                 140                 


Gly Ile Thr Pro Pro Ala Met Glu Gln Ser Gly Gly Phe Val Lys Glu 
145                 150                 155                 160 


Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro Phe Glu Ala Gly Lys 
                165                 170                 175     


Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala Ser Phe Ile Asp Leu 
            180                 185                 190         


Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met Val His Trp Trp Leu 
        195                 200                 205             


Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu Lys Glu Lys Lys Gly 
    210                 215                 220                 


Thr Val Asn Val Glu Glu Asn Tyr Ala Ile Thr Asp Leu Arg Arg Tyr 
225                 230                 235                 240 


Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser Arg Val Phe Asp Met Phe 
                245                 250                 255     


Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe Val Ser Asp Ala Leu 
            260                 265                 270         


Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys Ala Gln Gly Gly Val 
        275                 280                 285             


Asn Leu Glu Asp Ser Gln Leu Val Pro Asp Ser Arg Gly Gly Phe Phe 
    290                 295                 300                 


Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn Arg Ile Phe Ser Gly 
305                 310                 315                 320 


Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr Val Leu Glu Ser Lys 
                325                 330                 335     


Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly Tyr Ala Thr His Ile 
            340                 345                 350         


Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln Gly Lys Ile Lys Ala 
        355                 360                 365             


Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu Gln Ile Gly Leu Lys 
    370                 375                 380                 


Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn Pro Arg Leu Asn Asn 
385                 390                 395                 400 


His Met Lys Asn Asn Ser Ala Gly Ala Leu Leu Asp Tyr Val His Thr 
                405                 410                 415     


Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr Phe Asn Pro Leu Ala 
            420                 425                 430         


Lys Ala Lys Glu Thr Ala Ser Gln Thr Leu Ala Asp Thr Lys Lys Ala 
        435                 440                 445             


Leu Asp Leu Ser Ile Gln Gly Gln Ser Glu Leu Pro Glu Ser Met Arg 
    450                 455                 460                 


Leu Ile Tyr Leu Glu Lys Leu Asn Asn Leu Tyr Asn Gln Gly Ile Leu 
465                 470                 475                 480 


Ser Ile Gln Lys Ala Glu Ser Ser Glu Met Leu Ser Gly Ala Leu Glu 
                485                 490                 495     


Asn Gly Leu Asn Ser Leu Lys Ser Leu Asp Phe Pro Ile Ser Glu Val 
            500                 505                 510         


Gly Asn Ala Leu Ala Pro Asp Leu Pro Val Gly Asp Arg Ser Thr Val 
        515                 520                 525             


Ser Asp Val Asp Ser Leu Ser Ser Gln Glu Thr Ser Ser Thr Asn Leu 
    530                 535                 540                 


Glu Ala Asp Thr Glu Asn Ala Gly Ile Ile Ala Asp Gly Thr Asn Gln 
545                 550                 555                 560 


Leu His Phe Pro Val Glu Ala Gln Thr Thr Ser Ser Val Glu Ala Glu 
                565                 570                 575     


Gly Asp Asn Val Phe Glu Gln Glu Ala Asp Thr Leu Pro Ile Ile Ile 
            580                 585                 590         


Glu Asn Lys Asp Glu Phe Gly Ser Glu Leu Ser Arg Asn Met Gln Thr 
        595                 600                 605             


Ser Glu Thr Asp Ser Leu Val Val Ala Val Glu Glu Asp Val Lys Asn 
    610                 615                 620                 


Asp Glu Val Ala Gln Val Glu Glu Leu Leu Glu Ser Glu Lys Val Glu 
625                 630                 635                 640 


Asn Gln Ser Ser Glu Leu Leu Ser Asp Thr Leu Ile Val Glu Ser Ala 
                645                 650                 655     


Asn Asp Lys Glu Glu Asp Arg Val Glu Ala Val Val Ser Glu Gln Pro 
            660                 665                 670         


Asp Ser Ile Pro His Gln Asn Val Glu Ile Ser Leu Val Glu Pro Thr 
        675                 680                 685             


Asn Val Glu Thr Glu Thr Val Val Thr Pro Ile Asn Asp Ala Ala Thr 
    690                 695                 700                 


Pro His Gly Ser Pro Thr Tyr Ile Asp Asn Ser Val Thr Glu Ser Val 
705                 710                 715                 720 


Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr Glu Ile 
                725                 730                 735     


Ala Glu Pro Thr Ser Ser Glu Ser Thr Asn Val Glu Thr Glu Thr Val 
            740                 745                 750         


Val Thr Pro Val Asn Asp Val Ala Thr Pro His Gly Ser Pro Thr Tyr 
        755                 760                 765             


Ile Asp Asn Ser Val Thr Glu Ser Val Ala Thr Pro Leu Glu Lys Asp 
    770                 775                 780                 


Ser Ile Gln Ala Gly Glu Thr Glu Ile Ala Glu Pro Thr Ser Ser Glu 
785                 790                 795                 800 


Ser Thr Asn Val Glu Thr Glu Thr Val Val Thr Pro Val Asn Asp Val 
                805                 810                 815     


Ala Thr Pro His Gly Ser Pro Thr Tyr Ile Asp Asn Ser Val Thr Glu 
            820                 825                 830         


Ser Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr 
        835                 840                 845             


Glu Ile Ala Glu Pro Thr Ser Ser Glu Ser Thr Ser Val Glu Ala Glu 
    850                 855                 860                 


Leu Val Asp Asn Ser Glu Ile His Ala Ala Thr Ser Ser Val Thr Pro 
865                 870                 875                 880 


Cys Gly Ser Ser Ala Tyr Ala Asp Gly Ser Thr Thr Glu Ser Val Ala 
                885                 890                 895     


Thr Pro Leu Glu Lys Asp Ser Ile Gln Thr Gly Asn Thr Glu Ile Ala 
            900                 905                 910         


Glu Pro Thr Ser Ser Lys Ser Thr Asn Val Glu Ala Ala Ser Val Asp 
        915                 920                 925             


Asn Ser Glu Ile His Ala Asp Ala Ser Leu Thr Ala Val Ser Ser Val 
    930                 935                 940                 


Asn Leu Asp Asn Pro Val Ile Glu Pro Val Ala Ile Ser Leu Ile Gly 
945                 950                 955                 960 


Ser Lys Arg Asp Thr Asn Ala Glu Val Glu Val Ser Ser Leu Ser Lys 
                965                 970                 975     


Arg Glu Val Arg Lys Thr Asn Thr Asp Gly Leu Ile Ser Val Gln Ser 
            980                 985                 990         


Lys Val Ile Lys Lys Glu Leu Leu  Glu Ser Ser Leu Ala  Glu Ala Gly 
        995                 1000                 1005             


Ser Pro  Leu Leu Glu Ala Thr  Ile Ala Gln Ser Ser  Asn Ser Asn 
    1010                 1015                 1020             


Ser Thr  Glu Ile Gly Met Ser  Tyr Gln Asn Thr Val  Leu Leu Glu 
    1025                 1030                 1035             


Ser Asn  Asn Thr Glu Arg Gln  Val Ser Lys Ala Glu  Ile Val Met 
    1040                 1045                 1050             


Glu His  Lys Glu Thr Glu Leu  Val Glu Thr Val Ser  Ser Ala Ser 
    1055                 1060                 1065             


Glu Pro  Val Val Leu Val Glu  Asn Ile Ser Gln Thr  Ser Asn Asn 
    1070                 1075                 1080             


Thr Ile  Glu Ser Gly Lys Asn  Met Gly Val Gln Ser  Gln Ala Gly 
    1085                 1090                 1095             


Ala Lys  Gln Ile Leu Gly Val  Glu Gln Ser Ser Lys  Val Ser Thr 
    1100                 1105                 1110             


Pro Thr  Ser Arg Gln Ile Met  Gly Val Gly Leu Leu  Thr Leu Val 
    1115                 1120                 1125             


Leu Gly  Ser Ala Leu Gly Leu  Leu Lys Lys Arg Arg  Lys 
    1130                 1135                 1140     


<210>  2
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  rIdeSsuis

<400>  2

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Val Val Thr Gly Val Asn Glu Ile Ile 
            20                  25                  30          


Glu Glu Ser Gln Val Lys Asp Glu Val Ser Ile Glu Ser Glu Lys Asn 
        35                  40                  45              


Glu Ser Leu Asp Gly Ser Asn Ile Glu Ile Val Glu Glu Ile Ala Asp 
    50                  55                  60                  


Asn Ile Pro Ser Pro Val Ile Ala Glu Gly Glu Val Ala Val Glu Met 
65                  70                  75                  80  


Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu 
                85                  90                  95      


Val Thr Thr Ser Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu 
            100                 105                 110         


Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln 
        115                 120                 125             


Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser Gly 
    130                 135                 140                 


Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro 
145                 150                 155                 160 


Phe Glu Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala 
                165                 170                 175     


Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met 
            180                 185                 190         


Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu 
        195                 200                 205             


Lys Glu Lys Lys Gly Thr Val Asn Val Glu Glu Asn Tyr Ala Ile Thr 
    210                 215                 220                 


Asp Leu Arg Arg Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser Arg 
225                 230                 235                 240 


Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe 
                245                 250                 255     


Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys 
            260                 265                 270         


Ala Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp Ser 
        275                 280                 285             


Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn 
    290                 295                 300                 


Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr 
305                 310                 315                 320 


Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly 
                325                 330                 335     


Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln 
            340                 345                 350         


Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu 
        355                 360                 365             


Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn 
    370                 375                 380                 


Pro Arg Leu Asn Asn His Met Lys Asn Asn Ser Ala Gly Ala Leu Leu 
385                 390                 395                 400 


Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr 
                405                 410                 415     


Phe Asn Pro Leu Ala Lys Ala Lys Glu Thr Ala Ser Gln Thr Leu Ala 
            420                 425                 430         


Asp Thr Lys Lys Ala Leu Asp Leu Ser Ile Gln Gly Gln Ser Glu Leu 
        435                 440                 445             


Pro Glu Ser Met Arg Leu Ile Tyr Leu Glu Lys Leu Asn Asn Leu Tyr 
    450                 455                 460                 


Asn Gln Gly Ile Leu Ser Ile Gln Lys Ala Glu Ser Ser Glu Met Leu 
465                 470                 475                 480 


Ser Gly Ala Leu Glu Asn Gly Leu Asn Ser Leu Lys Ser Leu Asp Phe 
                485                 490                 495     


Pro Ile Ser Glu Val Gly Asn Ala Leu Ala Pro Asp Leu Pro Val Gly 
            500                 505                 510         


Asp Arg Ser Thr Val Ser Asp Val Asp Ser Leu Ser Ser Gln Glu Thr 
        515                 520                 525             


Ser Ser Thr Asn Leu Glu Ala Asp Thr Glu Asn Ala Gly Ile Ile Ala 
    530                 535                 540                 


Asp Gly Thr Asn Gln Leu His Phe Pro Val Glu Ala Gln Thr Thr Ser 
545                 550                 555                 560 


Ser Val Glu Ala Glu Gly Asp Asn Val Phe Glu Gln Glu Ala Asp Thr 
                565                 570                 575     


Leu Pro Ile Ile Ile Glu Asn Lys Asp Glu Phe Gly Ser Glu Leu Ser 
            580                 585                 590         


Arg Asn Met Gln Thr Ser Glu Thr Asp Ser Leu Val Val Ala Val Glu 
        595                 600                 605             


Glu Asp Val Lys Asn Asp Glu Val Ala Gln Val Glu Glu Leu Leu Glu 
    610                 615                 620                 


Ser Glu Lys Val Glu Asn Gln Ser Ser Glu Leu Leu Ser Asp Thr Leu 
625                 630                 635                 640 


Ile Val Glu Ser Ala Asn Asp Lys Glu Glu Asp Arg Val Glu Ala Val 
                645                 650                 655     


Val Ser Glu Gln Pro Asp Ser Ile Pro His Gln Asn Val Glu Ile Ser 
            660                 665                 670         


Leu Val Glu Pro Thr Asn Val Glu Thr Glu Thr Val Val Thr Pro Ile 
        675                 680                 685             


Asn Asp Ala Ala Thr Pro His Gly Ser Pro Thr Tyr Ile Asp Asn Ser 
    690                 695                 700                 


Val Thr Glu Ser Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala 
705                 710                 715                 720 


Gly Glu Thr Glu Ile Ala Glu Pro Thr Ser Ser Glu Ser Thr Asn Val 
                725                 730                 735     


Glu Thr Glu Thr Val Val Thr Pro Val Asn Asp Val Ala Thr Pro His 
            740                 745                 750         


Gly Ser Pro Thr Tyr Ile Asp Asn Ser Val Thr Glu Ser Val Ala Thr 
        755                 760                 765             


Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr Glu Ile Ala Glu 
    770                 775                 780                 


Pro Thr Ser Ser Glu Ser Thr Asn Val Glu Thr Glu Thr Val Val Thr 
785                 790                 795                 800 


Pro Val Asn Asp Val Ala Thr Pro His Gly Ser Pro Thr Tyr Ile Asp 
                805                 810                 815     


Asn Ser Val Thr Glu Ser Val Ala Thr Pro Leu Glu Lys Asp Ser Ile 
            820                 825                 830         


Gln Ala Gly Glu Thr Glu Ile Ala Glu Pro Thr Ser Ser Glu Ser Thr 
        835                 840                 845             


Ser Val Glu Ala Glu Leu Val Asp Asn Ser Glu Ile His Ala Ala Thr 
    850                 855                 860                 


Ser Ser Val Thr Pro Cys Gly Ser Ser Ala Tyr Ala Asp Gly Ser Thr 
865                 870                 875                 880 


Thr Glu Ser Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Thr Gly 
                885                 890                 895     


Asn Thr Glu Ile Ala Glu Pro Thr Ser Ser Lys Ser Thr Asn Val Glu 
            900                 905                 910         


Ala Ala Ser Val Asp Asn Ser Glu Ile His Ala Asp Ala Ser Leu Thr 
        915                 920                 925             


Ala Val Ser Ser Val Asn Leu Asp Asn Pro Val Ile Glu Pro Val Ala 
    930                 935                 940                 


Ile Ser Leu Ile Gly Ser Lys Arg Asp Thr Asn Ala Glu Val Glu Val 
945                 950                 955                 960 


Ser Ser Leu Ser Lys Arg Glu Val Arg Lys Thr Asn Thr Asp Gly Leu 
                965                 970                 975     


Ile Ser Val Gln Ser Lys Val Ile Lys Lys Glu Leu Leu Glu Ser Ser 
            980                 985                 990         


Leu Ala Glu Ala Gly Ser Pro Leu  Leu Glu Ala Thr Ile  Ala Gln Ser 
        995                 1000                 1005             


Ser Asn  Ser Asn Ser Thr Glu  Ile Gly Met Ser Tyr  Gln Asn Thr 
    1010                 1015                 1020             


Val Leu  Leu Glu Ser Asn Asn  Thr Glu Arg Gln Val  Ser Lys Ala 
    1025                 1030                 1035             


Glu Ile  Val Met Glu His Lys  Glu Thr Glu Leu Val  Glu Thr Val 
    1040                 1045                 1050             


Ser Ser  Ala Ser Glu Pro Val  Val Leu Val Glu Asn  Ile Ser Gln 
    1055                 1060                 1065             


Thr Ser  Asn Asn Thr Ile Glu  Ser Gly Lys Asn Met  Gly Val Gln 
    1070                 1075                 1080             


Ser Gln  Ala Gly Ala Lys Gln  Ile Leu Gly Val Glu  Gln Ser Ser 
    1085                 1090                 1095             


Lys Val  Ser Thr Pro Thr Ser  Arg Gln Ile Met Gly  Val Gly Leu 
    1100                 1105                 1110             


Leu Thr  Leu Val Leu Gly Ser  Ala Leu Gly Leu Leu  Lys Lys Arg 
    1115                 1120                 1125             


Arg Lys  
    1130 


<210>  3
<211>  3426
<212>  DNA
<213>  Streptococcus suis

<400>  3
atgaacattc aagaacgatt ttctttgaga aaatccgcgg ttggcttggt ctcagtctct       60

ttgctatgtg ctatttatac atccactgtt gctgccgata cagttgttac aggagtgaat      120

gaaataattg aagaatcaca agtcaaggat gaggtatcta ttgaatcaga aaaaaatgaa      180

tccctagatg gttctaatat tgaaattgta gaggaaatag cagacaacat cccatcacct      240

gttatcgctg aaggggaagt agcggtagag atgaaagttg acagagggac cgagaatgta      300

gtttctagaa atgatacaga agttacgacg agcgagcaaa atcagataga ggttactgag      360

acaaaagaaa ttttgaatca gaccagttat caaacggaga gtggcgagca acgacaaatt      420

atatgggccc atggaattac tcctcctgca atggaacaaa gcggtggttt tgtaaaggaa      480

aagtatggag actatttaaa ctatacagcg ccatttgagg ctggaaaagg ctactatgat      540

accaataaga gtctgaatgc ttcatttatt gaccttaatc tttgttttgc agctgtgtct      600

tcaaacatgg tacattggtg gttggaacag aatagttcct atgttgagcg atatctcaaa      660

gaaaaaaagg gtacagtaaa tgttgaagaa aactacgcaa taacggactt acggcgctat      720

attaattcat tccaaaatca acaaaatagt cgagtttttg atatgttcaa aacttactat      780

ggttatcgta caaatggttt tgtatcagat gccttggttg acttgtttat taacggatat      840

aaacctaagg cacagggcgg tgtcaatctg gaagatagcc agttagtacc agatagtagg      900

ggtggctttt tctacgacgt tttcaaagag aaaaaactga caaatcgaat ttttagtggt      960

agttatgagc ggtttggtga ggatgttcga actgttttgg aaagcaaagg attactcggc     1020

ttaacttata gaacattagg ttatgcaacg catattgtga cggtatgggg tgctgagtac     1080

gacaatcaag gtaagattaa ggctgtctat atcacagatt ctgatgatca acaagaacaa     1140

attggtttga agcgtatggg aatcactcgt gatgcttccg gaaatccacg tttgaataat     1200

catatgaaaa ataattcagc tggagcgctt ttggattatg tccatacaat ccgtctgggt     1260

caagacttat gggaagaata tttcaatccg cttgcaaaag ccaaagaaac agctagtcag     1320

acattagccg atacaaagaa ggcgttggat ttgtctattc aaggacaatc tgaattgcca     1380

gaatcaatgc gactgattta tcttgaaaaa ctaaataatc tctataatca aggaattcta     1440

tctattcaaa aggcagaaag ttctgagatg ctaagtggtg cattggaaaa tggtttaaat     1500

agtttaaaga gtttagattt tcctatttca gaagttggaa atgctttggc accagattta     1560

ccagtaggtg atcgctcaac ggtttcagat gttgattctc tatcatctca agaaacaagt     1620

tccacaaatt tggaagcaga cacagagaat gcaggtatta ttgcagatgg taccaatcaa     1680

ttgcattttc cagtggaggc ccaaacgaca tcttcagtag aggctgaggg agataatgtt     1740

tttgaacaag aggcagatac attaccaata attattgaaa acaaggatga atttggttca     1800

gaactatcaa gaaacatgca aacgtcagaa acggattcgc tagtagtagc tgttgaagaa     1860

gatgtgaaaa atgatgaggt agcccaagtt gaagagcttc ttgaatcaga aaaagttgaa     1920

aatcagagtt cggaacttct gtcagacacc ctaatcgtag agagtgcaaa tgacaaagaa     1980

gaagatagag tggaggcggt tgtttctgaa caaccagact caataccaca tcaaaatgta     2040

gaaatctctc ttgtagaacc aacgaatgtc gaaactgaaa ctgtggtcac tcctattaat     2100

gatgcagcta ctcctcatgg ttccccgacg tatatagata attccgtaac tgaatctgta     2160

gctactccac ttgaaaaaga ctccattcaa gccggggaga cagagattgc agaaccaacc     2220

tcgagcgaat caacgaatgt cgaaactgaa actgtggtca ctcctgttaa tgatgtagct     2280

actcctcatg gttccccgac gtatatagat aattccgtaa ctgaatctgt agctactcca     2340

cttgaaaaag actccattca agccggagag acagaaattg cagaaccaac ctcgagcgaa     2400

tcaacgaatg tcgaaactga aactgtggtc actcctgtta atgatgtagc tactcctcat     2460

ggttccccga cgtatataga taattccgta actgaatctg tagctactcc acttgaaaaa     2520

gactccattc aagccgggga gacagagatt gcagaaccaa cctcgagcga atcaactagt     2580

gttgaagctg aacttgtcga caattctgaa attcatgcag ctacctcttc agttactccc     2640

tgtggctcct cggcatatgc agatggttcc acaactgaat ctgtagccac tccgcttgaa     2700

aaagactcca ttcagactgg aaatacagaa attgcagaac caacctcgag caaatcaact     2760

aatgtagaag ctgcatctgt cgacaattct gaaattcatg cagatgcctc tctaactgct     2820

gtttcatcag ttaatctgga taatccagtg attgaaccag tagctatctc ccttatcggt     2880

tctaagaggg acacgaatgc agaagtagaa gtttcttcat tatcgaaaag agaggttaga     2940

aaaacaaata ctgacgggct aatctctgtt caatcaaaag ttattaagaa agaattgcta     3000

gaatcaagct tagcagaagc agggtctcca ttgctagaag ccaccattgc tcagtcttca     3060

aactcaaata gtactgagat aggtatgagc tatcagaata ctgtgttatt agagtctaat     3120

aatacagagc gtcaggtgtc taaagcagaa attgttatgg aacacaagga gacagagtta     3180

gttgaaacgg tttcatctgc ttctgagcct gtagtgctcg tagaaaatat ctcacaaacc     3240

tcaaataata ctattgaatc tggtaagaat atgggagttc aatctcaagc aggtgcaaaa     3300

caaattttag gcgtagaaca atcttcgaaa gtaagtacac ctacttcaag acagattatg     3360

ggagtcggtc tattgactct tgttcttggt agtgctttag gtttgttaaa gaaaagacgt     3420

aagtaa                                                                3426


<210>  4
<211>  3393
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding rIdeSsuis

<400>  4
atggcacatc accaccacca tcacgtgggt accggttcga atgatgacga cgacaagagt       60

ccggatccag ttgttacagg agtgaatgaa ataattgaag aatcacaagt caaggatgag      120

gtatctattg aatcagaaaa aaatgaatcc ctagatggtt ctaatattga aattgtagag      180

gaaatagcag acaacatccc atcacctgtt atcgctgaag gggaagtagc ggtagagatg      240

aaagttgaca gagggaccga gaatgtagtt tctagaaatg atacagaagt tacgacgagc      300

gagcaaaatc agatagaggt tactgagaca aaagaaattt tgaatcagac cagttatcaa      360

acggagagtg gcgagcaacg acaaattata tgggcccatg gaattactcc tcctgcaatg      420

gaacaaagcg gtggttttgt aaaggaaaag tatggagact atttaaacta tacagcgcca      480

tttgaggctg gaaaaggcta ctatgatacc aataagagtc tgaatgcttc atttattgac      540

cttaatcttt gttttgcagc tgtgtcttca aacatggtac attggtggtt ggaacagaat      600

agttcctatg ttgagcgata tctcaaagaa aaaaagggta cagtaaatgt tgaagaaaac      660

tacgcaataa cggacttacg gcgctatatt aattcattcc aaaatcaaca aaatagtcga      720

gtttttgata tgttcaaaac ttactatggt tatcgtacaa atggttttgt atcagatgcc      780

ttggttgact tgtttattaa cggatataaa cctaaggcac agggcggtgt caatctggaa      840

gatagccagt tagtaccaga tagtaggggt ggctttttct acgacgtttt caaagagaaa      900

aaactgacaa atcgaatttt tagtggtagt tatgagcggt ttggtgagga tgttcgaact      960

gttttggaaa gcaaaggatt actcggctta acttatagaa cattaggtta tgcaacgcat     1020

attgtgacgg tatggggtgc tgagtacgac aatcaaggta agattaaggc tgtctatatc     1080

acagattctg atgatcaaca agaacaaatt ggtttgaagc gtatgggaat cactcgtgat     1140

gcttccggaa atccacgttt gaataatcat atgaaaaata attcagctgg agcgcttttg     1200

gattatgtcc atacaatccg tctgggtcaa gacttatggg aagaatattt caatccgctt     1260

gcaaaagcca aagaaacagc tagtcagaca ttagccgata caaagaaggc gttggatttg     1320

tctattcaag gacaatctga attgccagaa tcaatgcgac tgatttatct tgaaaaacta     1380

aataatctct ataatcaagg aattctatct attcaaaagg cagaaagttc tgagatgcta     1440

agtggtgcat tggaaaatgg tttaaatagt ttaaagagtt tagattttcc tatttcagaa     1500

gttggaaatg ctttggcacc agatttacca gtaggtgatc gctcaacggt ttcagatgtt     1560

gattctctat catctcaaga aacaagttcc acaaatttgg aagcagacac agagaatgca     1620

ggtattattg cagatggtac caatcaattg cattttccag tggaggccca aacgacatct     1680

tcagtagagg ctgagggaga taatgttttt gaacaagagg cagatacatt accaataatt     1740

attgaaaaca aggatgaatt tggttcagaa ctatcaagaa acatgcaaac gtcagaaacg     1800

gattcgctag tagtagctgt tgaagaagat gtgaaaaatg atgaggtagc ccaagttgaa     1860

gagcttcttg aatcagaaaa agttgaaaat cagagttcgg aacttctgtc agacacccta     1920

atcgtagaga gtgcaaatga caaagaagaa gatagagtgg aggcggttgt ttctgaacaa     1980

ccagactcaa taccacatca aaatgtagaa atctctcttg tagaaccaac gaatgtcgaa     2040

actgaaactg tggtcactcc tattaatgat gcagctactc ctcatggttc cccgacgtat     2100

atagataatt ccgtaactga atctgtagct actccacttg aaaaagactc cattcaagcc     2160

ggggagacag agattgcaga accaacctcg agcgaatcaa cgaatgtcga aactgaaact     2220

gtggtcactc ctgttaatga tgtagctact cctcatggtt ccccgacgta tatagataat     2280

tccgtaactg aatctgtagc tactccactt gaaaaagact ccattcaagc cggagagaca     2340

gaaattgcag aaccaacctc gagcgaatca acgaatgtcg aaactgaaac tgtggtcact     2400

cctgttaatg atgtagctac tcctcatggt tccccgacgt atatagataa ttccgtaact     2460

gaatctgtag ctactccact tgaaaaagac tccattcaag ccggggagac agagattgca     2520

gaaccaacct cgagcgaatc aactagtgtt gaagctgaac ttgtcgacaa ttctgaaatt     2580

catgcagcta cctcttcagt tactccctgt ggctcctcgg catatgcaga tggttccaca     2640

actgaatctg tagccactcc gcttgaaaaa gactccattc agactggaaa tacagaaatt     2700

gcagaaccaa cctcgagcaa atcaactaat gtagaagctg catctgtcga caattctgaa     2760

attcatgcag atgcctctct aactgctgtt tcatcagtta atctggataa tccagtgatt     2820

gaaccagtag ctatctccct tatcggttct aagagggaca cgaatgcaga agtagaagtt     2880

tcttcattat cgaaaagaga ggttagaaaa acaaatactg acgggctaat ctctgttcaa     2940

tcaaaagtta ttaagaaaga attgctagaa tcaagcttag cagaagcagg gtctccattg     3000

ctagaagcca ccattgctca gtcttcaaac tcaaatagta ctgagatagg tatgagctat     3060

cagaatactg tgttattaga gtctaataat acagagcgtc aggtgtctaa agcagaaatt     3120

gttatggaac acaaggagac agagttagtt gaaacggttt catctgcttc tgagcctgta     3180

gtgctcgtag aaaatatctc acaaacctca aataatacta ttgaatctgg taagaatatg     3240

ggagttcaat ctcaagcagg tgcaaaacaa attttaggcg tagaacaatc ttcgaaagta     3300

agtacaccta cttcaagaca gattatggga gtcggtctat tgactcttgt tcttggtagt     3360

gctttaggtt tgttaaagaa aagacgtaag taa                                  3393


<210>  5
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  Partial sequence of Mac-1 domain

<400>  5

Met Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr 
1               5                   10                  15      


Glu Val Thr Thr Ser Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys 
            20                  25                  30          


Glu Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg 
        35                  40                  45              


Gln Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser 
    50                  55                  60                  


Gly Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala 
65                  70                  75                  80  


Pro Phe Glu Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn 
                85                  90                  95      


Ala Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn 
            100                 105                 110         


Met Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr 
        115                 120                 125             


Leu Lys Glu Lys Lys Gly Thr Val Asn Val Glu Glu Asn Tyr Ala Ile 
    130                 135                 140                 


Thr Asp Leu Arg Arg Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser 
145                 150                 155                 160 


Arg Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly 
                165                 170                 175     


Phe Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro 
            180                 185                 190         


Lys Ala Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp 
        195                 200                 205             


Ser Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr 
    210                 215                 220                 


Asn Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg 
225                 230                 235                 240 


Thr Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu 
                245                 250                 255     


Gly Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn 
            260                 265                 270         


Gln Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln 
        275                 280                 285             


Glu Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly 
    290                 295                 300                 


Asn Pro Arg Leu Asn Asn His Met Lys Asn Asn Ser Ala Gly Ala Leu 
305                 310                 315                 320 


Leu Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu 
                325                 330                 335 


<210>  6
<211>  457
<212>  PRT
<213>  Artificial

<220>
<223>  rIdeSsuis_homologue

<400>  6

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Val Val Thr Gly Val Asn Glu Ile Ile 
            20                  25                  30          


Glu Glu Ser Gln Val Lys Asp Glu Val Ser Ile Glu Ser Glu Lys Asn 
        35                  40                  45              


Glu Ser Leu Asp Gly Ser Asn Ile Glu Ile Val Glu Glu Ile Ala Asp 
    50                  55                  60                  


Asn Ile Pro Ser Pro Val Ile Ala Glu Gly Glu Val Ala Val Glu Met 
65                  70                  75                  80  


Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu 
                85                  90                  95      


Val Thr Thr Ser Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu 
            100                 105                 110         


Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln 
        115                 120                 125             


Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser Gly 
    130                 135                 140                 


Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro 
145                 150                 155                 160 


Phe Glu Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala 
                165                 170                 175     


Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met 
            180                 185                 190         


Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu 
        195                 200                 205             


Lys Glu Lys Lys Gly Thr Val Asn Val Glu Glu Asn Tyr Ala Ile Thr 
    210                 215                 220                 


Asp Leu Arg Arg Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser Arg 
225                 230                 235                 240 


Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe 
                245                 250                 255     


Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys 
            260                 265                 270         


Ala Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp Ser 
        275                 280                 285             


Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn 
    290                 295                 300                 


Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr 
305                 310                 315                 320 


Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly 
                325                 330                 335     


Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln 
            340                 345                 350         


Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu 
        355                 360                 365             


Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn 
    370                 375                 380                 


Pro Arg Leu Asn Asn His Met Lys Asn Asn Ser Ala Gly Ala Leu Leu 
385                 390                 395                 400 


Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr 
                405                 410                 415     


Phe Asn Pro Leu Ala Lys Ala Cys Arg Ser Thr Ser Leu Arg Pro His 
            420                 425                 430         


Ser Ser Leu Val Lys Lys Pro Leu Leu Arg Asn Leu Asn Ala Ser Thr 
        435                 440                 445             


Trp Thr Arg Leu Leu Ala Gln Leu Asn 
    450                 455         


<210>  7
<211>  1016
<212>  PRT
<213>  Artificial

<220>
<223>  rIdeSsuisB2

<400>  7

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Val Val Thr Gly Val Asn Glu Ile Ile 
            20                  25                  30          


Glu Glu Ser Gln Val Lys Asp Glu Val Ser Ile Glu Ser Glu Lys Asn 
        35                  40                  45              


Glu Ser Leu Asp Gly Ser Asn Ile Glu Ile Val Glu Glu Ile Ala Asp 
    50                  55                  60                  


Asn Ile Pro Ser Pro Val Ile Ala Glu Gly Glu Val Ala Val Glu Met 
65                  70                  75                  80  


Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu 
                85                  90                  95      


Val Thr Thr Ser Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu 
            100                 105                 110         


Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln 
        115                 120                 125             


Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser Gly 
    130                 135                 140                 


Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro 
145                 150                 155                 160 


Phe Lys Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala 
                165                 170                 175     


Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met 
            180                 185                 190         


Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu 
        195                 200                 205             


Lys Glu Lys Lys Gly Thr Val Asn Val Gly Glu Asn Tyr Ala Ile Thr 
    210                 215                 220                 


Asp Leu Arg Arg Tyr Ile Asp Ser Phe Gln Asp Gln Gln Asn Ser Arg 
225                 230                 235                 240 


Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe 
                245                 250                 255     


Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys 
            260                 265                 270         


Val Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp Ser 
        275                 280                 285             


Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn 
    290                 295                 300                 


Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr 
305                 310                 315                 320 


Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly 
                325                 330                 335     


Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln 
            340                 345                 350         


Gly Lys Ile Arg Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu 
        355                 360                 365             


Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn 
    370                 375                 380                 


Pro Arg Leu Asn Asn His Val Lys Asn Asn Ser Ala Gly Ala Leu Leu 
385                 390                 395                 400 


Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr 
                405                 410                 415     


Phe Asn Pro Phe Ala Lys Ala Lys Glu Ile Ala Ser Gln Ile Leu Ala 
            420                 425                 430         


Asp Arg Lys Lys Ala Leu Val Leu Ser Ile Gln Gly Gln Ser Glu Leu 
        435                 440                 445             


Pro Glu Ser Met Arg Leu Ile Tyr Leu Glu Lys Leu Asn Asn Leu Tyr 
    450                 455                 460                 


Asn Gln Gly Ile Leu Ser Ile Gln Lys Thr Glu Ser Ser Glu Met Leu 
465                 470                 475                 480 


Ser Gly Ala Leu Glu Asn Gly Leu Asn Ser Leu Lys Ser Leu Asp Phe 
                485                 490                 495     


Pro Ile Ser Glu Val Gly Asn Ala Leu Ala Pro Asp Leu Ser Val Gly 
            500                 505                 510         


Asp Arg Ser Thr Val Ser Asp Val Asp Ser Leu Ser Ser Gln Glu Thr 
        515                 520                 525             


Ser Ser Thr Asn Leu Glu Ala Asp Thr Glu Asn Ala Gly Ile Ile Ala 
    530                 535                 540                 


Asp Gly Thr Asn Gln Leu His Phe Pro Val Glu Ala Gln Thr Thr Ser 
545                 550                 555                 560 


Ser Val Glu Ala Glu Gly Asp Asn Val Phe Glu Gln Glu Ala Asp Thr 
                565                 570                 575     


Leu Pro Ile Ile Ile Glu Asn Lys Asp Glu Phe Gly Ser Glu Leu Ser 
            580                 585                 590         


Gly Asn Met Gln Thr Ser Glu Thr Asp Ser Leu Val Val Ala Val Glu 
        595                 600                 605             


Glu Asp Val Lys Asn Asp Glu Val Asp Gln Val Glu Lys Leu Leu Glu 
    610                 615                 620                 


Ser Glu Lys Val Glu Asn Gln Ser Ser Glu Leu Leu Ser Asp Thr Leu 
625                 630                 635                 640 


Ile Val Glu Gly Ala Asn Asp Lys Glu Glu Asp Arg Val Glu Ala Val 
                645                 650                 655     


Val Ser Glu Gln Pro Asp Ser Ile Pro His Gln Asn Val Glu Ile Ser 
            660                 665                 670         


Pro Val Glu Pro Met Asn Val Glu Thr Glu Ser Val Val Thr Pro Ile 
        675                 680                 685             


Asn Asp Ala Ala Thr Pro His Gly Phe Pro Met Tyr Ile Asp Asn Ser 
    690                 695                 700                 


Val Thr Glu Ser Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala 
705                 710                 715                 720 


Gly Glu Thr Glu Ile Ala Glu Pro Thr Ser Ser Glu Ser Thr Ser Val 
                725                 730                 735     


Glu Ala Glu Leu Val Asp Asn Ser Glu Ile His Ser Ala Thr Ser Ser 
            740                 745                 750         


Val Thr Pro Arg Gly Ser Ser Ala Tyr Ala Asp Ser Ser Thr Thr Glu 
        755                 760                 765             


Ser Val Ala Thr Leu Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr 
    770                 775                 780                 


Glu Ile Ala Glu Pro Thr Ser Ser Lys Ser Thr Asn Val Glu Ala Ala 
785                 790                 795                 800 


Ser Val Asp Asn Ser Glu Ile His Ala Asp Thr Ser Leu Thr Ala Val 
                805                 810                 815     


Ser Ser Val Asn Leu Asp Asn Pro Val Ile Glu Pro Val Ala Ile Pro 
            820                 825                 830         


Leu Ile Gly Ser Lys Arg Asp Thr Asn Ala Glu Val Glu Val Ser Ser 
        835                 840                 845             


Leu Ser Lys Arg Glu Val Arg Lys Pro Asn Thr Glu Gly Leu Ile Ser 
    850                 855                 860                 


Val Gln Ser Lys Val Ile Lys Lys Glu Leu Leu Glu Ser Ser Leu Val 
865                 870                 875                 880 


Glu Ala Gly Ser Pro Leu Leu Glu Ala Thr Ile Ala Gln Ser Ser Asn 
                885                 890                 895     


Ser Asn Ser Thr Glu Ile Gly Met Ser Tyr Gln Asn Thr Val Leu Leu 
            900                 905                 910         


Glu Ser Asn Asn Thr Glu Arg Gln Val Ser Lys Ala Glu Ile Val Ile 
        915                 920                 925             


Glu His Lys Glu Thr Glu Leu Val Glu Thr Val Ser Ser Ala Ser Glu 
    930                 935                 940                 


Pro Val Val Leu Val Glu Asn Ile Ser Gln Thr Ser Asn Asn Thr Ile 
945                 950                 955                 960 


Glu Ser Gly Lys Asn Met Gly Val Gln Ser Gln Ala Gly Ala Lys Gln 
                965                 970                 975     


Ile Leu Gly Ile Glu Gln Ser Ser Lys Val Ser Thr Pro Thr Ser Arg 
            980                 985                 990         


Gln Ile Met Gly Val Gly Leu Leu  Thr Leu Val Leu Gly  Ser Ala Leu 
        995                 1000                 1005             


Gly Leu  Leu Lys Lys Arg Arg  Lys 
    1010                 1015     


<210>  8
<211>  1374
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding rIdeSsuis_homologue

<400>  8
atggcacatc accaccacca tcacgtgggt accggttcga atgatgacga cgacaagagt       60

ccggatccag ttgttacagg agtgaatgaa ataattgaag aatcacaagt caaggatgag      120

gtatctattg aatcagaaaa aaatgaatcc ctagatggtt ctaatattga aattgtagag      180

gaaatagcag acaacatccc atcacctgtt atcgctgaag gggaagtagc ggtagagatg      240

aaagttgaca gagggaccga gaatgtagtt tctagaaatg atacagaagt tacgacgagc      300

gagcaaaatc agatagaggt tactgagaca aaagaaattt tgaatcagac cagttatcaa      360

acggagagtg gcgagcaacg acaaattata tgggcccatg gaattactcc tcctgcaatg      420

gaacaaagcg gtggttttgt aaaggaaaag tatggagact atttaaacta tacagcgcca      480

tttgaggctg gaaaaggcta ctatgatacc aataagagtc tgaatgcttc atttattgac      540

cttaatcttt gttttgcagc tgtgtcttca aacatggtac attggtggtt ggaacagaat      600

agttcctatg ttgagcgata tctcaaagaa aaaaagggta cagtaaatgt tgaagaaaac      660

tacgcaataa cggacttacg gcgctatatt aattcattcc aaaatcaaca aaatagtcga      720

gtttttgata tgttcaaaac ttactatggt tatcgtacaa atggttttgt atcagatgcc      780

ttggttgact tgtttattaa cggatataaa cctaaggcac agggcggtgt caatctggaa      840

gatagccagt tagtaccaga tagtaggggt ggctttttct acgacgtttt caaagagaaa      900

aaactgacaa atcgaatttt tagtggtagt tatgagcggt ttggtgagga tgttcgaact      960

gttttggaaa gcaaaggatt actcggctta acttatagaa cattaggtta tgcaacgcat     1020

attgtgacgg tatggggtgc tgagtacgac aatcaaggta agattaaggc tgtctatatc     1080

acagattctg atgatcaaca agaacaaatt ggtttgaagc gtatgggaat cactcgtgat     1140

gcttccggaa atccacgttt gaataatcat atgaaaaata attcagctgg agcgcttttg     1200

gattatgtcc atacaatccg tctgggtcaa gacttatggg aagaatattt caatccgctt     1260

gcaaaagcct gcaggtcgac aagcttgcgg ccgcactcga gtctggtaaa gaaaccgctg     1320

ctgcgaaatt tgaacgccag cacatggact cgtctactag cgcagcttaa ttaa           1374


<210>  9
<211>  3051
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleotide sequence encoding rIdeSsuisB2

<400>  9
atggcacatc accaccacca tcacgtgggt accggttcga atgatgacga cgacaagagt       60

ccggatccag ttgttacagg agtgaatgaa ataattgaag aatcacaagt caaggatgag      120

gtatctattg aatcagaaaa aaatgaatcc ctagatggtt ctaatattga aattgtagag      180

gaaatagcag acaacatccc atcacctgtt atcgctgaag gggaagtagc ggtagagatg      240

aaagttgaca gagggaccga gaatgtagtt tctagaaatg atacagaagt tacgacgagc      300

gagcaaaatc agatagaggt tactgagaca aaagaaattt tgaatcagac cagttatcaa      360

acggagagtg gcgagcaacg acaaattata tgggcccatg gaattactcc tcctgcaatg      420

gaacaaagcg gtggttttgt aaaggaaaag tatggagact atttaaacta tacagcgcca      480

tttaaggcag gaaaaggcta ttatgatacc aataaaagtc tcaatgcttc atttattgac      540

cttaacctat gttttgcagc cgtgtcttcc aacatggtac attggtggtt ggaacagaat      600

agttcctatg ttgagcgata tctcaaagaa aaaaagggta cagtaaatgt tggggaaaac      660

tatgcaataa cggacctacg tcgctatatt gattcgttcc aggatcagca aaatagtcga      720

gtctttgata tgttcaaaac ttactacggt tatcgtacaa atggttttgt gtcagatgcc      780

ctagttgact tgtttattaa tggatataaa cctaaggtac agggtggtgt caatctggaa      840

gatagccagt tagtaccaga tagtaggggt ggctttttct acgacgtttt caaagagaaa      900

aaactgacaa atcgtatttt tagtggtagc tatgagcgtt ttggtgagga tgttcgaact      960

gttttggaga gcaaaggatt actcggtcta acttatagaa cattaggcta tgcaacgcat     1020

attgtgacgg tatggggtgc tgagtacgat aatcaaggta agattagggc tgtctatatc     1080

actgattccg atgatcaaca agaacaaatt ggtttgaagc gtatgggaat cactcgtgat     1140

gcttctggaa atccgcgttt gaataatcat gtgaaaaata attcagctgg ggcgcttttg     1200

gattatgtcc atacaatccg tcttggtcaa gacttatggg aagaatattt caatccgttc     1260

gcaaaagcca aagaaatagc tagtcagata ctagctgata gaaagaaggc gttggttctg     1320

tctattcaag gacaatctga attgccagaa tcaatgcggc tgatttatct tgaaaaacta     1380

aataatctct ataatcaagg gattctatct attcaaaaga cagaaagttc tgagatgcta     1440

agtggtgcat tggaaaatgg tttaaatagt ttaaagagtt tagattttcc tatttcagaa     1500

gttggaaatg ctttggcacc agatttatca gtaggtgatc gctcaacggt ttcagatgtt     1560

gattctctat catctcaaga aacaagttcc acaaatttgg aagcagacac agagaatgca     1620

ggtattattg cagatggtac caatcaattg cattttccag tggaggccca aacgacatct     1680

tcagtagagg ctgagggaga taatgttttt gaacaagagg cagatacatt accaataatt     1740

attgaaaaca aggatgaatt tggttcagaa ctatcaggaa acatgcaaac gtcagaaacg     1800

gattcgctag tagtagctgt tgaagaagat gtgaaaaatg atgaggtaga ccaagttgaa     1860

aagcttcttg aatcagaaaa agttgaaaat cagagttcgg aacttctgtc agacacccta     1920

atcgtagagg gtgcaaatga caaagaagaa gatagagtgg aggcggttgt ttctgaacaa     1980

ccagactcaa taccacatca aaatgtagaa atctctcctg tagaaccaat gaatgtcgaa     2040

actgaatctg tggtcactcc tattaatgat gcagctactc ctcatggttt cccgatgtat     2100

atagataatt ccgtaactga atctgtagct actccacttg aaaaagactc cattcaagcc     2160

ggagagacag aaattgcaga accaacctcg agcgaatcaa ctagtgttga agctgaactt     2220

gtcgacaatt ctgaaatcca ttcagctacc tcttcagtta ctccccgtgg ttcctcggca     2280

tatgcagata gttccacaac tgaatctgta gctactctgc ttgaaaaaga ctccattcag     2340

gctggagaga cagaaattgc agaaccaacc tcgagcaaat caactaatgt cgaagctgca     2400

tctgtcgaca attctgaaat tcatgcagat acctctctaa ctgctgtttc atcagtcaat     2460

ctggataatc cagtgattga accagtagct atccccctta tcggttctaa gagggacacg     2520

aatgcagaag tggaagtttc ttcattatcg aaaagagagg ttagaaaacc aaatactgaa     2580

gggctaatct ctgttcaatc aaaagttatt aagaaagaat tgctagaatc aagcttagta     2640

gaagcagggt ctccattgct agaagccacc attgctcagt cttcaaactc aaatagtact     2700

gagataggta tgagctatca gaatactgtg ttattagagt ctaataatac agagcgtcag     2760

gtgtctaaag cagaaattgt tatagaacac aaggagacag agttagttga aacggtttca     2820

tctgcttctg agcctgtagt gctcgtagaa aatatctcac aaacctcaaa taatactatt     2880

gaatctggta agaatatggg agttcaatct caagcaggtg caaaacaaat tttaggcata     2940

gaacaatctt cgaaagtaag tacacctact tcaagacaga ttatgggagt cggtctattg     3000

actcttgttc ttggtagtgc tttaggtttg ttaaagaaaa gacgtaagta a              3051


<210>  10
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  amino acids 91 to 425 of WP_044671938

<400>  10

Met Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr 
1               5                   10                  15      


Glu Val Thr Thr Ser Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys 
            20                  25                  30          


Glu Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg 
        35                  40                  45              


Gln Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser 
    50                  55                  60                  


Gly Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala 
65                  70                  75                  80  


Pro Phe Lys Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn 
                85                  90                  95      


Ala Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn 
            100                 105                 110         


Met Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr 
        115                 120                 125             


Leu Lys Glu Lys Lys Gly Thr Val Asn Val Gly Glu Asn Tyr Ala Ile 
    130                 135                 140                 


Thr Asp Leu Arg Arg Tyr Ile Asp Ser Phe Gln Asp Gln Gln Asn Ser 
145                 150                 155                 160 


Arg Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly 
                165                 170                 175     


Phe Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro 
            180                 185                 190         


Lys Val Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp 
        195                 200                 205             


Ser Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr 
    210                 215                 220                 


Asn Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg 
225                 230                 235                 240 


Thr Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu 
                245                 250                 255     


Gly Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn 
            260                 265                 270         


Gln Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln 
        275                 280                 285             


Glu Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly 
    290                 295                 300                 


Asn Pro Arg Leu Asn Asn His Met Lys Asn Asn Ser Ala Gly Ala Leu 
305                 310                 315                 320 


Leu Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu 
                325                 330                 335 


<210>  11
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  amino acids 91 to 425 of WP_002935529

<400>  11

Met Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr 
1               5                   10                  15      


Glu Val Thr Thr Ser Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys 
            20                  25                  30          


Glu Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg 
        35                  40                  45              


Gln Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser 
    50                  55                  60                  


Gly Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala 
65                  70                  75                  80  


Pro Phe Lys Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn 
                85                  90                  95      


Ala Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn 
            100                 105                 110         


Met Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr 
        115                 120                 125             


Leu Lys Glu Lys Lys Gly Thr Val Asn Val Gly Glu Asn Tyr Ala Ile 
    130                 135                 140                 


Thr Asp Leu Arg Arg Tyr Ile Asp Ser Phe Gln Asp Gln Gln Asn Ser 
145                 150                 155                 160 


Arg Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly 
                165                 170                 175     


Phe Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro 
            180                 185                 190         


Lys Val Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp 
        195                 200                 205             


Ser Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr 
    210                 215                 220                 


Asn Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg 
225                 230                 235                 240 


Thr Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu 
                245                 250                 255     


Gly Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn 
            260                 265                 270         


Gln Gly Lys Ile Arg Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln 
        275                 280                 285             


Glu Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly 
    290                 295                 300                 


Asn Pro Arg Leu Asn Asn His Val Lys Asn Asn Ser Ala Gly Ala Leu 
305                 310                 315                 320 


Leu Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu 
                325                 330                 335 


<210>  12
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  amino acids 92 to 426 of WP_015647040

<400>  12

Met Lys Val Asp Arg Gly Thr Glu Asn Val Val Ser Arg Asn Asp Lys 
1               5                   10                  15      


Glu Val Thr Thr Ser Glu Lys Asn Gln Ile Glu Val Thr Glu Thr Lys 
            20                  25                  30          


Glu Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg 
        35                  40                  45              


Gln Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser 
    50                  55                  60                  


Gly Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala 
65                  70                  75                  80  


Pro Phe Glu Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn 
                85                  90                  95      


Ala Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn 
            100                 105                 110         


Met Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr 
        115                 120                 125             


Leu Lys Glu Lys Asn Ser Thr Val Asn Val Gly Glu Asn Tyr Ala Ile 
    130                 135                 140                 


Thr Asp Leu Arg Arg Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser 
145                 150                 155                 160 


Arg Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly 
                165                 170                 175     


Phe Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro 
            180                 185                 190         


Lys Ala Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp 
        195                 200                 205             


Ser Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr 
    210                 215                 220                 


Asn Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg 
225                 230                 235                 240 


Thr Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu 
                245                 250                 255     


Gly Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn 
            260                 265                 270         


Gln Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln 
        275                 280                 285             


Glu Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly 
    290                 295                 300                 


Asn Pro Arg Leu Asn Asn His Val Lys Asn Asn Ser Ala Gly Ala Leu 
305                 310                 315                 320 


Leu Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu 
                325                 330                 335 


<210>  13
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  amino acids 92 to 426 of WP_023370787

<400>  13

Met Lys Ser Asp Asn Gly Asp Glu Asn Ala Val Ser Arg Asp Asp Ser 
1               5                   10                  15      


Glu Val Thr Thr Asn Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys 
            20                  25                  30          


Glu Ile Leu Asn Gln Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg 
        35                  40                  45              


Gln Ile Ile Trp Ala His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser 
    50                  55                  60                  


Gly Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala 
65                  70                  75                  80  


Pro Phe Glu Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn 
                85                  90                  95      


Ala Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn 
            100                 105                 110         


Met Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr 
        115                 120                 125             


Leu Lys Glu Lys Lys Gly Thr Val Asn Val Glu Glu Asn Tyr Ala Ile 
    130                 135                 140                 


Thr Asp Ile Arg Arg Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser 
145                 150                 155                 160 


Arg Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly 
                165                 170                 175     


Phe Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro 
            180                 185                 190         


Lys Ser Gln Gly Gly Val Asn Leu Glu Asp Ser His Leu Val Pro Asp 
        195                 200                 205             


Ser Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr 
    210                 215                 220                 


Asn Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg 
225                 230                 235                 240 


Thr Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu 
                245                 250                 255     


Gly Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn 
            260                 265                 270         


Gln Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln 
        275                 280                 285             


Glu Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly 
    290                 295                 300                 


Asn Pro Arg Leu Asn Asn His Met Lys Asn Asn Ser Ala Gly Ala Leu 
305                 310                 315                 320 


Leu Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu 
                325                 330                 335 


<210>  14
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  amino acids 92 to 426 of WP_044678723

<400>  14

Met Asn Ser Asp Asn Gly Asp Glu Asn Val Val Ser Arg Asp Asp Ser 
1               5                   10                  15      


Glu Val Thr Thr Asn Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys 
            20                  25                  30          


Glu Ile Leu Asn Tyr Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg 
        35                  40                  45              


Gln Ile Val Trp Ala Tyr Gly Ile Thr Pro Pro Val Met Glu Gln Lys 
    50                  55                  60                  


Gly Gly Phe Val Lys Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala 
65                  70                  75                  80  


Pro Phe Glu Ala Gly Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn 
                85                  90                  95      


Ala Ser Phe Ile Asp Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn 
            100                 105                 110         


Met Val His Trp Trp Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr 
        115                 120                 125             


Leu Lys Glu Lys Lys Gly Thr Val Asn Val Glu Glu Asn Tyr Ala Ile 
    130                 135                 140                 


Thr Asp Leu Arg Arg Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser 
145                 150                 155                 160 


Arg Val Phe Asp Met Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly 
                165                 170                 175     


Phe Val Ser Asp Ala Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro 
            180                 185                 190         


Lys Ala Gln Gly Gly Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp 
        195                 200                 205             


Ser Arg Gly Gly Phe Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr 
    210                 215                 220                 


Asn Arg Ile Phe Ser Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg 
225                 230                 235                 240 


Thr Val Leu Glu Ser Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu 
                245                 250                 255     


Gly Tyr Ala Thr His Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn 
            260                 265                 270         


Gln Gly Lys Ile Lys Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln 
        275                 280                 285             


Glu Gln Ile Gly Leu Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly 
    290                 295                 300                 


Asn Pro Arg Leu Asn Asn His Met Lys Asn Asn Ser Ala Gly Ala Leu 
305                 310                 315                 320 


Leu Asp Tyr Val His Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu 
                325                 330                 335 


