                         SEQUENCE LISTING

<110>  Morris, Kevin
       Saayman, Sheena
 
<120>  SPECIFIC TARGETED ACTIVATION OF CYSTIC FIBROSIS TRANSMEMBRANE 
       CONDUCTANCE REGULATOR (CFTR)

<130>  1647.1PC

<140>  PCT/US2015/031995
<141>  2015-05-21

<150>  US62/002,462
<151>  2014-05-23

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  208
<212>  DNA
<213>  Homo sapiens

<400>  1
gtaatatatc taaaaaacac atcaactttg gcagtcaaaa tgaaaatata ctgaatcatg       60

aatgtttgca tttggtgatc ggggcttcat agagaacata ttgagggatt cttgtgctgg      120

caccagctgc ttaaccatca aggattctgt tatgaaatac tattcctgga agaaggcctt      180

ttgaggaatg aagtatatcc tctttgag                                         208


<210>  2
<211>  421
<212>  DNA
<213>  Homo sapiens

<400>  2
tcggagaaaa gaaccaagct ttattagttt caggtttagg tgagtgaact ccaagggtgg       60

cacagaaatc ttaggacacg tactgaaaga gaaaaaaaaa tctgcaagga ggtaagagga      120

gataatgctt tgcgtaatta ccggcccagg atgtgttcct tgtctatcct ttttagccca      180

gtgcgcattt ttaaggaagg ctttggagtg ttttagcgat aatgacaagg aacaatgtaa      240

actaacccgc cctcctatag atttcctagt ctcagtcagc aaaacatctt gactaatcca      300

ccgaaaggaa gccaagcagt ctttgaagcg aaggtaatgt gttaactttg acctgactca      360

gagaaacgcc atcttcaact ctctgagggg catctgggca ttcccaggcg taggcgcctt      420

c                                                                      421


<210>  3
<211>  658
<212>  DNA
<213>  Homo sapiens

<400>  3
cttttctccg acacgcaaag gaagcgctaa ggtaaatgca tcagacccac actgccgcgg       60

aacttttcgg ctctctaagg ctgtattttg atatacgaaa ggcacatttt ccttcccttt      120

tcaaaatgca ccttgcaaac gtaacaggaa cccgactagg atcatcggga aaaggaggag      180

gaggaggaag gcaggctccg gggaagctgg tggcagcggg tcctgggtct ggcggaccct      240

gacgcgaagg agggtctagg aagctctccg gggagccggt tctcccgccg gtggcttctt      300

ctgtcctcca gcgttgccaa ctggacctaa agagaggccg cgactgtcgc ccacctgcgg      360

gatgggcctg gtgctgggcg gtaaggacac ggacctggaa ggagcgcgcg cgagggaggg      420

aggctgggag tcagaatcgg gaaagggagg tgcggggcgg cgagggagcg aaggaggaga      480

ggaggaagga gcgggagggg tgctggcggg ggtgcgtagt gggtggagaa agccgctaga      540

gcaaatttgg ggccggacca ggcagcactc ggcttttaac ctgggcagtg aaggcggggg      600

aaagagcaaa aggaaggggt ggtgtgcgga gtaggggtgg gtggggggaa ttggaagc        658


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4
gccagcacaa gaatccctca                                                   20


<210>  5
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  5
ccaaatgcaa acattcatga ttc                                               23


<210>  6
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6
gcggctagcc ttttctccga cacgcaaagg aagcgctaag gt                          42


<210>  7
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7
gcgggtaccg cttccaattc cccccaccca cccctactcc gcaca                       45


<210>  8
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8
tgcaaacgta acaggaaccc gact                                              24


<210>  9
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9
tctttaggtc cagttggcaa cgct                                              24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10
ggaagcaaat gacatcacag cagg                                              24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11
tgggctcaag ctcctaatgc caaa                                              24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12
aagactgctt ggcttccttt cggt                                              24


<210>  13
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13
aatgctttgc gtaattaccg gccc                                              24


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14
gtggaggaaa gcctttggag t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15
acagatctga gcccaacctc a                                                 21


<210>  16
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16
agcctttaga gagaaggctg tcct                                              24


<210>  17
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17
gtgtggatgc tgttgtcttt cggt                                              24


<210>  18
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18
ctcatgggat gtgattcttt cgacc                                             25


<210>  19
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  19
tttctgtcca ggagacagga gcat                                              24


<210>  20
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20
gtgccagcac aagaatccct caat                                              24


<210>  21
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21
tgttctcatc tccagttcca agtc                                              24


<210>  22
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22
ttgatggtta agcagctggt gcc                                               23


<210>  23
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23
gaatgtttgc atttggtgat cggg                                              24


<210>  24
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24
ggtgattatg ggagaactgg ag                                                22


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25
tctttaatgg tgccaggcat a                                                 21


<210>  26
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26
tttggactta cctcaaagag gat                                               23


<210>  27
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27
tccaacctcc aggttatgaa at                                                22


<210>  28
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28
tttggactta cctcaaagag gat                                               23


<210>  29
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29
tccaacctcc aggttatgaa at                                                22


<210>  30
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30
cctttccaac aacctgaaca aa                                                22


<210>  31
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31
gcctgtaaca actcccagat ta                                                22


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32
gcttcctatg acccggataa c                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33
ggagcagtgt cctcacaata a                                                 21


<210>  34
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34
caggcaaact tgactgaact gg                                                22


<210>  35
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35
gcattctact caattgcatt ctgtggg                                           27


<210>  36
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36
cgtactgaaa gagaaaaaaa aatc                                              24


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37
tctgcaagga ggtaagagga g                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  38
tggcacagaa atcttaggac a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  39
tcttaggaca cgtactgaaa g                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  40
ctttggagtg ttttagcgat a                                                 21


<210>  41
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  41
gcggctagct cggagaaaag aaccaagctt tattagtttc aggtttagg                   49


<210>  42
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  42
gcgggtaccg aaggcgccta cgcctgggaa tgcccagatg cccctc                      46


<210>  43
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  43
gcggctagcc ttttctccga cacgcaaagg aagcgctaag gt                          42


<210>  44
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  44
gcgggtaccg cttccaattc cccccaccca cccctactcc gcaca                       45


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  45
gaggaagagg agggcatctc g                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  46
tgtccagtcc cagaaggaag c                                                 21


<210>  47
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  47
ctctgatgaa gcaggagaga aag                                               23


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  48
agacagggac cactgataag a                                                 21


<210>  49
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  49
ggcagcagcg aaggataaat                                                   20


<210>  50
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  50
ccgcaggtaa gtcttcttta gtt                                               23


<210>  51
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  51
ggaatgctgc ctctgatctt                                                   20


<210>  52
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  52
atggagtacc tcaaagcaga ac                                                22


<210>  53
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  53
tcataaggct gcttgtcatc t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  54
gctctgagta tcgcccaaaa a                                                 21


<210>  55
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  55
ccacatctct cccagtttct tc                                                22


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  56
gttcggcctt cttcctcttc                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  57
cggagggtga aagaaggata tg                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  58
gggcaactct ggtttactct t                                                 21


<210>  59
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  59
cuggagauga gaacagaaua uu                                                22


<210>  60
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  60
auucaugauu caguatauuu ucaucuug                                          28


<210>  61
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  61
acugccaaag uugaucugu                                                    19


<210>  62
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  62
cauuuuugtg uuuuuguuca a                                                 21


<210>  63
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  63
uaguuuucug auuucaguuu g                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  64
ugcacaacau auuucacaua g                                                 21


<210>  65
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  65
auauuucaca uaguuuucug a                                                 21


<210>  66
<211>  17
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  66
ggccuucuuc caggaau                                                      17


<210>  67
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  67
cucaauaugu ucucuaugaa g                                                 21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  68
gcacaagaau cccucaauau g                                                 21


<210>  69
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  69
uauacuucau uccucaaaag g                                                 21


<210>  70
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  70
cagtgaattg taatacgact cactataggg gtaatatatc ta                          42


<210>  71
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  71
ctcaaagagg atatacttca ttcctcaaaa gg                                     32


<210>  72
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  72
cagtgaattg taatacgact cactataggg cttttctccg ac                          42


<210>  73
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  73
gcttccaatt ccccccacc                                                    19


<210>  74
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  74
cagtgaattg taatacgact cactataggg tcggagaaaa ga                          42


<210>  75
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  75
gaaggcgcct acgcctg                                                      17


<210>  76
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  76
gccagcacaa gaatccctca                                                   20


<210>  77
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  77
ccaaatgcaa acattcatga ttc                                               23


