                         SEQUENCE LISTING

<110>  Centro de Investigacion y de Estudios Avanzados del 
       Instituto Politecnico Nacional
 
<120>  Nanoparticle gene system with apoptotic effect with tumor 
       specificity for cancer therapy

<130>  Cinvestav27

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  1
atggtggccg cgctgctggg cggcggcggc gaggcccgcg gggggacagt gccgggcgcc       60

tggctgtgcc tgatggcgct gctgcagctg ctgggctcgg cgccgcgggg atcggggctg      120

gcgcacggcc gccgcctcat ctgctggcag gcgctgctgc agtgccaggg ggagccggag      180

tgcagctacg cctacaacca gtacgccgag gcgtgcgcgc cggtgctggc gcagcacggc      240

gggggcgacg cgcccggggc cgccgccgcc gctttcccgg cctcggccgc ctctttctcg      300

tcgcgctggc gctgcccgag tcactgcatc tcggccctca ttcagctcaa ccacacgcgc      360

cgcgggcccg ccctggagga ctgtgactgc gcgcaggacg agaactgcaa gtccaccaag      420

cgcgccattg agccgtgcct gccccggacg agcggcggcg gcgcgggcgg ccccggcgcg      480

ggcggggtca tgggctgcac cgaggcccgg cggcgctgcg accgcgacag ccgctgcaac      540

ctggcgctga gccgctacct gacctactgc ggcaaagtct tcaacgggct gcgctgcacg      600

gacgaatgcc gcaccgtcat tgaggacatg ctggctatgc ccaaggcggc gctgctcaac      660

gactgcgtgt gcgacggcct cgagcggccc atctgcgagt cggtcaagga gaacatggcc      720

cgcctgtgct tcggcgccga gctgggcaac ggccccggca gcagcggctc ggacgggggc      780

ctggacgact actacgatga ggactacgat gacgagcagc gcaccggggg cgcgggtggt      840

gagcagccgc tggacgacga cgacggcgtc ccgcacccac cgcgcccggg cagcggcgct      900

gctgcatcgg gcggccgcgg ggacctgccc tatgggcctg ggcgcaggag cagcggcggc      960

ggcggccgct tggcgccccg gggcgcctgg accccactcg cctccatctt gctgctgctg     1020

cttgggccgc tcttttag                                                   1038


<210>  2
<211>  948
<212>  DNA
<213>  Homo sapiens

<400>  2
atggtggccg cgctgctggg cggcggcggc gaggcccgcg gggggacagt gccgggcgcc       60

tggctgtgcc tgatggcgct gctgcagctg ctgggctcgg cgccgcgggg atcggggctg      120

gcgcacggcc gccgcctcat ctgctggcag gcgctgctgc agtgccaggg ggagccggag      180

tgcagctacg cctacaacca gtacgccgag gcgtgcgcgc cggtgctggc gcagcacggc      240

gggggcgacg cgcccggggc cgccgccgcc gctttcccgg cctcggccgc ctctttctcg      300

tcgcgctggc gctgcccgag tcactgcatc tcggccctca ttcagctcaa ccacacgcgc      360

cgcgggcccg ccctggagga ctgtgactgc gcgcaggacg agaactgcaa gtccaccaag      420

cgcgccattg agccgtgcct gccccggacg agcggcggcg gcgcgggcgg ccccggcgcg      480

ggcggggtca tgggctgcac cgaggcccgg cggcgctgcg accgcgacag ccgctgcaac      540

ctggcgctga gccgctacct gacctactgc ggcaaagtct tcaacgggct gcgctgcacg      600

gacgaatgcc gcaccgtcat tgaggacatg ctggctatgc ccaaggcggc gctgctcaac      660

gactgcgtgt gcgacggcct cgagcggccc atctgcgagt cggtcaagga gaacatggcc      720

cgcctgtgct tcggcgccga gctgggcaac ggccccggca gcagcggctc ggacgggggc      780

ctggacgact actacgatga ggactacgat gacgagcagc gcaccggggg cgcgggtggt      840

gagcagccgc tggacgacga cgacggcgtc ccgcacccac cgcgcccggg cagcggcgct      900

gctgcatcgg gcggccgcgg ggacctgccc tatgggcctg ggcgcagg                   948


<210>  3
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  3
atggtggccg cgctgctggg cggcggcggc gaggcccgcg gggggacagt gccgggcgcc       60

tggctgtgcc tgatggcgct gctgcagctg ctgggctcgg cgccgcgggg atcggggctg      120

gcgcacggcc gccgcctcat ctgctggcag gcgctgctgc agtgccaggg ggagccggag      180

tgcagctacg cctacaacca gtacgccgag gcgtgcgcgc cggtgctggc gcagcacggc      240

gggggcgacg cgcccggggc cgccgccgcc gctttcccgg cctcggccgc ctctttctcg      300

tcgcgctggc gctgcccgag tcactgcatc tcggccctca ttcagctcaa ccacacgcgc      360

cgcgggcccg ccctggagga ctgtgactgc gcgcaggacg agaactgcaa gtccaccaag      420

cgcgccattg agccgtgcct gccccggacg agcggcggcg gcgcgggcgg ccccggcgcg      480

ggcggggtca tgggctgcac cgaggcccgg cggcgctgcg accgcgacag ccgctgcaac      540

ctggcgctga gccgctacct gacctactgc ggcaaagtct tcaacgggct gcgctgcacg      600

gacgaatgcc gcaccgtcat tgaggacatg ctggctatgc ccaaggcggc gctgctcaac      660

gactgcgtgt gcgacggcct cgagcggccc atctgcgagt cggtcaagga gaacatggcc      720

cgcctgtgct tcggcgcc                                                    738


<210>  4
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  4
atggtggccg cgctgctggg cggcggcggc gaggcccgcg gggggacagt gccgggcgcc       60

tggctgtgcc tgatggcgct gctgcagctg ctgggctcgg cgccgcgggg atcggggctg      120

gcgcacggcc gccgcctcat ctgctggcag gcgctgctgc agtgccaggg ggagccggag      180

tgcagctacg cctacaacca gtacgccgag gcgtgcgcgc cggtgctggc gcagcacggc      240

gggggcgacg cgcccggggc cgccgccgcc gctttcccgg cctcggccgc ctctttctcg      300

tcgcgctggc gctgcccgag tcactgcatc tcggccctca ttcagctcaa ccacacgcgc      360

cgcgggcccg ccctggagga ctgtgactgc gcgcaggacg agaactgcaa gtccaccaag      420

cgcgccattg agccgtgcct gccccggacg agcggcggcg gcgcgggcgg ccccggcgcg      480

ggcggggtca tgggctgcac c                                                501


<210>  5
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr 
                165         


<210>  6
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp 
                165                 170                 175     


Ser Arg Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys 
            180                 185                 190         


Val Phe Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu 
        195                 200                 205             


Asp Met Leu Ala Met Pro Lys Ala Ala Leu Leu Asn Asp Cys Val Cys 
    210                 215                 220                 


Asp Gly Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala 
225                 230                 235                 240 


Arg Leu Cys Phe Gly Ala 
                245     


<210>  7
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp 
                165                 170                 175     


Ser Arg Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys 
            180                 185                 190         


Val Phe Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu 
        195                 200                 205             


Asp Met Leu Ala Met Pro Lys Ala Ala Leu Leu Asn Asp Cys Val Cys 
    210                 215                 220                 


Asp Gly Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala 
225                 230                 235                 240 


Arg Leu Cys Phe Gly Ala Glu Leu Gly Asn Gly Pro Gly Ser Ser Gly 
                245                 250                 255     


Ser Asp Gly Gly Leu Asp Asp Tyr Tyr Asp Glu Asp Tyr Asp Asp Glu 
            260                 265                 270         


Gln Arg Thr Gly Gly Ala Gly Gly Glu Gln Pro Leu Asp Asp Asp Asp 
        275                 280                 285             


Gly Val Pro His Pro Pro Arg Pro Gly Ser Gly Ala Ala Ala Ser Gly 
    290                 295                 300                 


Gly Arg Gly Asp Leu Pro Tyr Gly Pro Gly Arg Arg 
305                 310                 315     


<210>  8
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp 
                165                 170                 175     


Ser Arg Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys 
            180                 185                 190         


Val Phe Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu 
        195                 200                 205             


Asp Met Leu Ala Met Pro Lys Ala Ala Leu Leu Asn Asp Cys Val Cys 
    210                 215                 220                 


Asp Gly Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala 
225                 230                 235                 240 


Arg Leu Cys Phe Gly Ala Glu Leu Gly Asn Gly Pro Gly Ser Ser Gly 
                245                 250                 255     


Ser Asp Gly Gly Leu Asp Asp Tyr Tyr Asp Glu Asp Tyr Asp Asp Glu 
            260                 265                 270         


Gln Arg Thr Gly Gly Ala Gly Gly Glu Gln Pro Leu Asp Asp Asp Asp 
        275                 280                 285             


Gly Val Pro His Pro Pro Arg Pro Gly Ser Gly Ala Ala Ala Ser Gly 
    290                 295                 300                 


Gly Arg Gly Asp Leu Pro Tyr Gly Pro Gly Arg Arg Ser Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Arg Leu Ala Pro Arg Gly Ala Trp Thr Pro Leu Ala Ser Ile 
                325                 330                 335     


Leu Leu Leu Leu Leu Gly Pro Leu Phe 
            340                 345 


<210>  9
<211>  29
<212>  DNA
<213>  Homo Sapiens

<400>  9
ccggaattcg cgatggtggc cgcgctgct                                         29


<210>  10
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  10
atgctagcct acctgcgccc aggcccata                                         29


<210>  11
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  11
atgctagcct aggcgccgaa gcacaggcg                                         29


<210>  12
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  12
atgctagcct aggtgcagcc catgacccc                                         29


<210>  13
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  13
gagggacacg tcgactacta                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
ttcactgcat tctagttgtg                                                   20


<210>  15
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  15
gctgacgtag aagag                                                        15


<210>  16
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  16
cgtggagctg tacaacttca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  17
cagccagcag accacaaagg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  18
aggaattgac ggaagggcac                                                   20


<210>  19
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  19
gtgcagcccc ggacatctaa g                                                 21


<210>  20
<211>  13
<212>  PRT
<213>  Sinttico

<400>  20

Glu Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              


<210>  21
<211>  25
<212>  PRT
<213>  Virus influenza

<400>  21

Gly Leu Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ile Glu Gly Cys Ala Lys Lys Lys 
            20                  25  


<210>  22
<211>  19
<212>  PRT
<213>  Sinttico

<400>  22

Met Ala Pro Thr Lys Arg Lys Gly Ser Cys Pro Gly Ala Ala Pro Asn 
1               5                   10                  15      


Lys Pro Lys 
            


<210>  23
<211>  22
<212>  DNA
<213>  Sinttico

<400>  23
tcgagaggga cacgtcgaaa tt                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Sinttico

<400>  24
ttggtggact tgcagttctc gt                                                22


<210>  25
<211>  21
<212>  DNA
<213>  Sinttico

<400>  25
ctggtcgagc tggacggcga c                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Sinttico

<400>  26
agagtgatcc cggcggcggt c                                                 21


