                         SEQUENCE LISTING

<110>  BASF SE
 
<120>  GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND 
       HYDROXYCORNEXISTIN

<130>  0000077174

<150>  EP14169318.4
<151>  2014-05-21

<150>  EP14169323.4
<151>  2014-05-21

<160>  350   

<170>  PatentIn version 3.5

<210>  1
<211>  8222
<212>  DNA
<213>  Talaromyces stipitatus

<400>  1
atgtcacctc ttattcacga tgaccaaccc tactcatgga acgcggctat gccaattgcc       60

gttgtgggta ttggcttccg cggtcctgga gacgcaacga atgttgagaa tctcttcaga      120

atgattgccg aaggcaggga aagtcgaatt gatataccta aggagaaatg gaaccatgaa      180

gccttttatc atcctgaccc cagtcggttt ggaactgtaa gttgatcaca ttcaacataa      240

ccaattgata tgagaaagcg aggttaattg aaacagcaca atgtcaccgg aggacattac      300

ttccaacaag atgtctcgcg ttttgacgct ccattcttta atatgacagc agccgaggct      360

gccgcccttg atcctcagca gagaatgctt ctagaatgca catacgaagc catggagaac      420

tcaggcacca agatgcatga cttcgttggc agcaatacat ccgtctttgt cggctcgttc      480

tgcgcagatt atgctgatgt cctctggcga gaccctgaaa cggtgcccat gtatcaatgc      540

accaatgctg gtcattctcg cgcaaatacg gcgaaccgtg tctcatatat ttatgatctg      600

aaagggccaa gtgtgactgt ggatactgcc tgttcggcaa gtttggtggc tctgcactta      660

ggatgtcaga gtttgaggac cggtgatgct aagcaggctc tcgttgccgg ttgcagtgcc      720

attctaagcc atgaaggaat ggttacaatg agtatgatga ggtatgctat cctttgtgta      780

acatctaact ttcgatgtga gaccccttga actttgtgga aattaaccta atatacctcc      840

agacttctct ctcccgaagg gcgctgttac acattcgacg agcgcgcagg aggttatgcc      900

cgaggcgatg gtgtcggtgc gatccttttg aaacctctac aagacgccct ggatgcggga      960

gacacaattc gggcagtcat tcgcggcact ggatcaaatc aagatggcaa aacgcccgga     1020

atcaccatgc cgagtggcac agcccaagaa gctcttgttc gtagtgttta tgagaagatt     1080

ggtctcgatc ctcttgacac aagctacgtt gagtgtcacg gaactgggac tcaagctggt     1140

gaggtcaata tctcttgtca cggtggaagt atgctaaatt cgtttaaata ggcgatgtca     1200

ctgagactag cgcccttgct cgtgtctttg aacccggtcg accgaaggat gagccactgg     1260

taattggctc tgtgaagacc aatatcggcc atttggaggg tgcaagtggt gttgctggag     1320

tcataaagac cattctcatg ttagagaacg gccttattct tcccaacagg aatttccaga     1380

aaggaaatcc aaagatcttg tttgacgaat ggaaattacg agtatgactt gactccatct     1440

tgctgttttt agacatatac tgaattcctt gcaggttccc ttgggagtcg agaattggga     1500

aatatccaag cctcgccgag cctctgtgaa cagttttgga tacggaggtg ccaatgcgca     1560

tgtcgtcctt gagaatgcac aagactactt gcgaaaccac aactgggaat tccgatccca     1620

tacgaggaaa tctgccactg gtgctgtttt atccaacagc aagctgacca gtgctgtagc     1680

tgctcttgag accggatcta cgactaccga aatcataaat actcctagcg aagagtcatc     1740

cgggaccagc actccttcaa accctggtcc tcacggccgc ctcttcgttt tctcttcatt     1800

cgacgaggcc actggaaaga agtacctcca gagtttcgag aagtatatag aagatagatt     1860

gcaaatcgcg gactcagaag agttcctcga tgacctcgca tatactctgg gagagcgaag     1920

gacaaatcat acttggcgta cagccgttcc agcgcagtca gcagaggagc ttttgagcaa     1980

tttgcgtgaa ggtataaact tgggcaatgc tagccagact aagaatcgca agattggctt     2040

cgtgttcact ggccagggtg cgcagtggtg tggaatgggt aaagagttaa ttgatcagta     2100

tcctgtcttt aaggagacca tcgagaaggc tggaattgcg tgtcaaaaag ccggcgcaac     2160

atttgatctt gaaagtaaga tgctactctg caaattttgg tttcgattta tactgatggt     2220

atgacagccg agcttcgcaa ggaccccaaa gagtccgcaa tcaaccgtgc aatctattct     2280

caaccacttt caacggctgt tcagctgggt ctgattgatc tgctggcttc gtggggcgtg     2340

aagcctacct ctgttactgg tcactccagt ggcgaaattg cttctgccta tgctgctggg     2400

gctctcagcc ttgaggacgc catgttggta tcctattctc gtggtgttgt ttccagcaag     2460

atggccgagc gtgccaccgt ccctggatgc atgatggcaa ttggtatgtc gaaggaggaa     2520

gtgcttccta ttgtttcaac cctcacgaag ggcaaagttg tcgtagcatg ctccaacagt     2580

ccttccagcg tgaccgcctc tggtgaccta ccggccattg atgagttgca tactgtcctt     2640

gatgaaaagg gtgtctttaa ccgcaagctg gttgtggagg ttgcctatca ttctcaccac     2700

atggagctcg ttaaagaaga gtacaggaac gccatttcct ctattaaggt ccaacccggc     2760

aatgacgttg agttcttctc ttctgttact ggagaacgtg cttcaatctc gggtcttggt     2820

cccgattact gggtatccaa catgattgga gaagtcaagt tcaatgattc acttggtcgc     2880

ctgtgcttag agaccgaagg tccatcagca accaccaaga agagtgctca acgtcgcaaa     2940

gcgaaggtct ctccggtcag cactctgatt gagattggcc ctcattcggc acttgctggg     3000

cccatcaaac agatcatcca agcaaatgag accctcaaca aggcgtctat caagtactac     3060

tctgctctgg tcagaaacaa gaacgccgcc actactgtcc ttaatctagt cggtcagctc     3120

ttcgttgctg gacacgagcc aagccttgaa aaggtcaaca gacctacagg tcttgaaagt     3180

cactctgttc ttattgacct gcctccatat gcttggaatc acgcaaactc atactgggca     3240

gagtcgcgca ttagcaagtt ctaccgtgag cgacgcttcc cacgaactga cctccttggt     3300

gttctggaga ggaactccag ctctatagaa cctcgctggc gcaaccatat ccgactgtca     3360

gaaatcccct gggttcgcga tcacaagatt caaggtaaca ttgtttaccc ggcagctgga     3420

tatctcgcca tggctattga agcagcttgt cagcatgcta ttaccgttaa gtccattccc     3480

acaattacgg gttataagct tcgcgaggtt gtaattgact ctgctctcat tattccggag     3540

aatcccggtg aggtcgaagt tgccatcaca ttgaagtcat tcacggacag tatccgcaat     3600

ccttcagata tgtgggacga atttgtcatt tcatcagtca acgccgacag tcgctggact     3660

gaacattgtc gtggtcttgt ctctgttgtg gctccacaaa aggtcgtcaa tgtcattgat     3720

ggacaggccc agagtattgc tgaaaagcaa gggtatgccg aactcgttgc cagctatgaa     3780

accaaatgcc gccgaaacat caatgttcct caattctatg agcagcttat cgagcttggt     3840

cttgagtatg gaccaacatt tgccaacctc aagcgagcaa aggcagctcc caatgcgtgc     3900

attggtgatt tagagattcc ggataccgcc gctgttatgc catataactt ccagttccca     3960

tttgtcattc acccagctac gttggatgcc ttgttccata ctatctttgc agccctagct     4020

actgccaacg gcggcaccct caaggatcct gccgttcctg tctcggccag cgaaatcttt     4080

gtttcggcca atattacctc taagcccggt gacaagctcg ccacttacac atcaactgag     4140

cagaaggact accgtttcat gtctgcttct atgactgtgt tccatgagag ccaaaagcaa     4200

cagggcgctt ttgagcccgt tattgagatc aaggacttga catgtgccac acttgctcgt     4260

gaaggggctg atccttcgac ggacggccag gtaaccaaag cctataacct agcgtggaag     4320

ccaagcattg acttgctgtc ccaatctgaa atcttggaac tatgcgctaa gacaagttct     4380

ccagaaggca acaccaatgc cacaaatgcg agagagttgc tcgaacgtgc tgcctactac     4440

atgctcaaga gggccgttgc aggctatgcg cctcctgaga ctaattccgc ttatgcgcaa     4500

caactgtggt cattcctcaa gtcacagagt agagttgctt cgtggaaaca tgcttacgac     4560

ggctgggacc agctattcaa agctgatgtt gacgcattca ttgacaaggt cgtgtcttca     4620

tcaagcgtcg gcaagtttct ggttgaagtt ggcgacaaac tacctaacct tgtaaaagga     4680

gagaattctt ctgctgaatt tatcaaggaa ctagacctca aggtgttcgt ggacaatact     4740

cagttattcc aaaataccca gtcagcagcg cggtactttg acctacttca acacaaaacg     4800

ccgagtttgt ctgtccttgc tgttgggcca ggatcaggag ttgcatctct gggattcctc     4860

gctttgctta ataaaaagtc atccgctcca tttgagcggt atgagcacaa cgacgtcgag     4920

tttgacatca gggacgtcgt caaagagaag ttcccacagt gggctcaact catcggaacg     4980

aagcaagttg acatcagccg cgaaattcaa ggtcaggaag atattgagcc caattcgtac     5040

gatgtcctag ttgccttcca tgtcctcggg gacgcaactg gaatgaataa tgtgcttgct     5100

caatccaagc agcttctcaa gccagatggc aaggtgttgt ttattgggcg gcccctgaaa     5160

tcgcttgtcg catccgtgct tttcggatac gtgccctctg ttttggcaga gactggatcc     5220

acgtctgacc gtagcaatct gtcgccagcg gaaattgacg acatggtctc cgcaagcggg     5280

tactcaaagg ttacggccat tgctacttcc attaacagca ataactacag catgatggtt     5340

gtttccgcaa gtgcttccca ggatacaagt gcaaaacctc agaaggtcca tgtcatcgcc     5400

gaggatgaga gtactagtca gccgtctctc ctggctggtc taaaagagga aggcattgag     5460

gtaacagtct cttcgctttc ggaagctagt ccaactccag accacatgtg catagtgctc     5520

agcgatctgt cgaacaagac ggtcttgtcg gacccatctg ttcaagaatg ggaagcactg     5580

aagaagatca tgctcgaagc caagggtgta ctatgggtaa cgcgtggtag tgccgttacc     5640

acatcaaacc ctaatggtag catggctact ggtctgagcc gtacaattcg ctctgaaaga     5700

ggagacgtcc ctgttgtcac ccttgatctt gatgctgaaa gaacactcga tgacgcagtg     5760

tcgaccgata ttattttgaa agtcttccgc aagagtttct atcccgcttt cactgcttcc     5820

gaagtcgagc aagagtacgc agagcgaaaa ggtcgacttt tggtgccccg tttgatcgag     5880

gacgaagaat tgaccaagac cctcgctatc gcaacagagg gtgctaaggg tcaactcgag     5940

ccccttcatc aacccggacg tcctctgcgc atgtttgtcg gcacaccagg tctcctcgac     6000

agcattttct ggacggatga tgatcgcgtc gagactcctt tgccggatga ctgggttgag     6060

atggaagtca aggcatccgg cttcaacttc aaggacgtca tgatggccat gggccagatc     6120

aaagtcgaga acctaggctg ggaatgcagt ggtatactaa ctaaggttgg tccagcagtc     6180

accggacttg ctgtaggtga tcgagtggta tgccatgcct ccggaacttt ctgtaccaat     6240

gcccgagtgc atgtggacaa tgtacgaaag atccccgaca ctatgtcctt tgagattgca     6300

gcatcgcttc cagtcactta cgtgactgca taccactcca tctacaatat cgctcgcctc     6360

caaaagggtg agacaatcct agtccacgct gcaaccggtg gtctcggcca agccattatc     6420

gaattgtgcc aactcatagg cgccgaaatc ttcgctacag tgggcacctt agacaagaag     6480

aaattcctca tagaccactt ccacattccg gaagatcata tcttcttcag tcgtgatcag     6540

agcttcgccg cgggtataaa gcgcatgact aggggtaagg gtgttgatgc agtcatgaac     6600

tctcttgccg gtgaaggact tcgtctttct tgggaatgta ttgcacccta tggccgattt     6660

gttgagcttg gccagcgcga tattggcatt aattcgcgac ttgaaatggg tcaatttatc     6720

aagaacactt cattcacggc attcaacttg gcttacatgg ttcaatataa tcccaaggtg     6780

gccaatgaag tgtttacgag cgttttaaat ctgttctgga aagatgctat caagggtcct     6840

tcgccagttg aggtgtacag tttctcggac gttgaaaagg catttagaag aatgcagaca     6900

ggtggccata tgggtaagct agttggaacg gctgacacag atgcgatggt gaaggtgaat     6960

tgtctcttct tggttgttgc actatatcat ggtctaatgc tatttttagg ttattccact     7020

tgacagaagc aagtccctgc tccggtcaga tgcctcttac gttcttattg gtggtctcgg     7080

tggtattgga cgagccactg ctctctggat ggttgaacac ggtgctcgga atgttatctt     7140

cgttaaccgc agtggtgtca aggtcgatga ggctcgagag accattcgtg tattggagga     7200

gatggagtgc aagactgcaa tattcccctg cgatatcact aatgaaaacc aagttgaaac     7260

atttgttggg gatgctgcta aagctatgcc acctattaaa ggtgtcatcc agggtgctat     7320

gctactcagg gtatgttgtc gacccctatc cattaatagg tgtattgaac tctaacgaga     7380

cataaaaaca ggacacacta tttgagaaga tgtctcttga agactacatt acggtcctcc     7440

gtcccaaggt tcaaggaaca tttaatctgc acaagtacct gccaaaagat atggatttct     7500

tcatcatgga atcttccgtc agtggcatcg taggcaatgc ctctcaagct gcctacgccg     7560

ccggaaacac attcctcgat gcatttgcaa gctaccgcgt atctcagggt ctgcctgcca     7620

ctaccatcga cctgggcgct atctccggag tgggatatct ctccactaac tcagaactca     7680

aacaagccat ggaacgtcag ggattcgaat tcaccaaccc taagcgtcta atggcgctca     7740

tcgagtcagc aattcgtaat cctgcacgtc ctggtcaaca agctcacatc attactgggc     7800

ttggaacctg gaacgaagac agttcgctcg gagcattaac tctaccaatg ttctcgcact     7860

ttcggcactt aagtgccggt aacgcagact ggggcaaatc aggtagtggt aacaatctca     7920

aatcggcact caaagccgca aagactcttg acgatgcaag cgagttaatc ctcggtgcat     7980

tgatcgataa gattgcttct agatccggca ttggtccaga aaatattaac acttccaagt     8040

cgatgcctga ctatggtatt gactcgctcg ttgcggtaga gatgaggaac tggatcacca     8100

aggatatgga tagtacgttg ccagtgctgg aattattagc tagtgacccc ttgacgcact     8160

tggccaccaa gatcgcgcag agatcacgct cagtgcaggt tgcagagcaa acgcatgagt     8220

ag                                                                    8222


<210>  2
<211>  2570
<212>  PRT
<213>  Talaromyces stipitatus

<400>  2

Met Ser Pro Leu Ile His Asp Asp Gln Pro Tyr Ser Trp Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Met Ile Ala Glu Gly Arg Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Lys Glu Lys Trp Asn His Glu Ala Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Asp Val Leu Trp Arg Asp Pro Glu Thr Val Pro Met Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Ile Leu Ser His 
    210                 215                 220                 


Glu Gly Met Val Thr Met Ser Met Met Arg Leu Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Lys Thr Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Ala Arg Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Glu Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Leu Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Asp Glu Trp Lys Leu Arg Val Pro Leu Gly Val Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Lys Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Tyr Leu 
        435                 440                 445             


Arg Asn His Asn Trp Glu Phe Arg Ser His Thr Arg Lys Ser Ala Thr 
    450                 455                 460                 


Glu Ser Ser Gly Thr Ser Thr Pro Ser Asn Pro Gly Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Lys Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Ile Ala Asp Ser 
            500                 505                 510         


Glu Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Gly Glu Arg Arg Thr 
        515                 520                 525             


Asn His Thr Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Leu Ser Asn Leu Arg Glu Gly Ile Asn Leu Gly Asn Ala Ser Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Asp Gln Tyr Pro Val Phe Lys Glu 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Thr Phe 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Ile Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Lys Met Ala Glu Arg Ala Thr Val Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Glu Val Leu Pro Ile Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Thr Val Leu Asp Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Lys Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Lys Glu Glu Tyr Arg Asn Ala Ile Ser Ser Ile 
    770                 775                 780                 


Lys Val Gln Pro Gly Asn Asp Val Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Ser Ile Ser Gly Leu Gly Pro Asp Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Asp Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Lys Val Ser Pro Val Ser Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Lys Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Ile Lys Tyr Tyr Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Ala Ala Thr Thr Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Glu Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Gly Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Ile Ser Lys Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Glu Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Lys Ile Gln  Gly Asn Ile Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Val  Lys Ser Ile Pro Thr  Ile Thr Gly Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Ser Ala Leu  Ile Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Thr Leu  Lys Ser Phe Thr Asp  Ser Ile Arg 
    1055                 1060                 1065             


Asn Pro  Ser Asp Met Trp Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Arg Trp Thr Glu  His Cys Arg Gly Leu  Val Ser Val 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Val  Asn Val Ile Asp Gly  Gln Ala Gln 
    1100                 1105                 1110             


Ser Ile  Ala Glu Lys Gln Gly  Tyr Ala Glu Leu Val  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Thr  Lys Cys Arg Arg Asn  Ile Asn Val Pro Gln  Phe Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Ile Glu Leu Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Ala  Pro Asn Ala Cys Ile  Gly Asp Leu 
    1160                 1165                 1170             


Glu Ile  Pro Asp Thr Ala Ala  Val Met Pro Tyr Asn  Phe Gln Phe 
    1175                 1180                 1185             


Pro Phe  Val Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Ile Phe  Ala Ala Leu Ala Thr  Ala Asn Gly Gly Thr  Leu Lys Asp 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Ser Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Ile Thr  Ser Lys Pro Gly Asp  Lys Leu Ala Thr Tyr  Thr Ser Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Met Ser Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Ala Phe Glu Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Thr Cys Ala  Thr Leu Ala Arg Glu  Gly Ala Asp 
    1280                 1285                 1290             


Pro Ser  Thr Asp Gly Gln Val  Thr Lys Ala Tyr Asn  Leu Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Ile Asp Leu Leu  Ser Gln Ser Glu Ile  Leu Glu Leu 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Gly Asn Thr Asn  Ala Thr Asn 
    1325                 1330                 1335             


Ala Arg  Glu Leu Leu Glu Arg  Ala Ala Tyr Tyr Met  Leu Lys Arg 
    1340                 1345                 1350             


Ala Val  Ala Gly Tyr Ala Pro  Pro Glu Thr Asn Ser  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Leu  Lys Ser Gln Ser Arg  Val Ala Ser 
    1370                 1375                 1380             


Trp Lys  His Ala Tyr Asp Gly  Trp Asp Gln Leu Phe  Lys Ala Asp 
    1385                 1390                 1395             


Val Asp  Ala Phe Ile Asp Lys  Val Val Ser Ser Ser  Ser Val Gly 
    1400                 1405                 1410             


Lys Phe  Leu Val Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Asn Thr Gln  Leu Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Asp Leu Leu  Gln His Lys Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Ser Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Asn Lys Lys  Ser Ser Ala Pro Phe  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Val Glu Phe  Asp Ile Arg Asp Val  Val Lys Glu 
    1505                 1510                 1515             


Lys Phe  Pro Gln Trp Ala Gln  Leu Ile Gly Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Arg Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Asn Ser 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Met Asn  Asn Val Leu Ala Gln  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Val Ala 
    1580                 1585                 1590             


Ser Val  Leu Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Ser Asp Arg Ser Asn  Leu Ser Pro Ala Glu  Ile Asp Asp 
    1610                 1615                 1620             


Met Val  Ser Ala Ser Gly Tyr  Ser Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Ser Asn Asn Tyr  Ser Met Met Val Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Asp Thr Ser Ala  Lys Pro Gln Lys Val  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Glu Ser Thr Ser  Gln Pro Ser Leu Leu  Ala Gly Leu 
    1670                 1675                 1680             


Lys Glu  Glu Gly Ile Glu Val  Thr Val Ser Ser Leu  Ser Glu Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Met  Cys Ile Val Leu Ser  Asp Leu Ser 
    1700                 1705                 1710             


Asn Lys  Thr Val Leu Ser Asp  Pro Ser Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Lys Ile Met Leu Glu  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Val Thr Thr  Ser Asn Pro Asn Gly  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Val Pro 
    1760                 1765                 1770             


Val Val  Thr Leu Asp Leu Asp  Ala Glu Arg Thr Leu  Asp Asp Ala 
    1775                 1780                 1785             


Val Ser  Thr Asp Ile Ile Leu  Lys Val Phe Arg Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Arg Leu Leu Val Pro  Arg Leu Ile Glu Asp  Glu Glu Leu 
    1820                 1825                 1830             


Thr Lys  Thr Leu Ala Ile Ala  Thr Glu Gly Ala Lys  Gly Gln Leu 
    1835                 1840                 1845             


Glu Pro  Leu His Gln Pro Gly  Arg Pro Leu Arg Met  Phe Val Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Ser  Ile Phe Trp Thr Asp  Asp Asp Arg 
    1865                 1870                 1875             


Val Glu  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Met Ala  Met Gly Gln 
    1895                 1900                 1905             


Ile Lys  Val Glu Asn Leu Gly  Trp Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Val Cys  His Ala Ser Gly Thr  Phe Cys Thr Asn Ala  Arg Val His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Lys Ile  Pro Asp Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Val Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Ile  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Asp Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Ile Asp His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Gly Ile  Lys Arg Met 
    2045                 2050                 2055             


Thr Arg  Gly Lys Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Ile Gly Ile Asn  Ser Arg Leu 
    2090                 2095                 2100             


Glu Met  Gly Gln Phe Ile Lys  Asn Thr Ser Phe Thr  Ala Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Asn Pro Lys Val Ala  Asn Glu Val 
    2120                 2125                 2130             


Phe Thr  Ser Val Leu Asn Leu  Phe Trp Lys Asp Ala  Ile Lys Gly 
    2135                 2140                 2145             


Pro Ser  Pro Val Glu Val Tyr  Ser Phe Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Met Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Thr Asp Ala Met  Val Lys Val Ile Pro  Leu Asp Arg 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Ser  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Gly Val Lys 
    2225                 2230                 2235             


Val Asp  Glu Ala Arg Glu Thr  Ile Arg Val Leu Glu  Glu Met Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Ile Phe Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Glu  Thr Phe Val Gly Asp  Ala Ala Lys Ala Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Phe 
    2285                 2290                 2295             


Glu Lys  Met Ser Leu Glu Asp  Tyr Ile Thr Val Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Phe Asn Leu  His Lys Tyr Leu Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Val Ser Gly Ile  Val Gly Asn 
    2330                 2335                 2340             


Ala Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Leu Ser  Thr Asn Ser 
    2375                 2380                 2385             


Glu Leu  Lys Gln Ala Met Glu  Arg Gln Gly Phe Glu  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Leu Met Ala Leu  Ile Glu Ser Ala Ile  Arg Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Gly Gln Gln Ala  His Ile Ile Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Gly Ala Leu Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Leu Ser  Ala Gly Asn Ala Asp  Trp Gly Lys 
    2450                 2455                 2460             


Ser Gly  Ser Gly Asn Asn Leu  Lys Ser Ala Leu Lys  Ala Ala Lys 
    2465                 2470                 2475             


Thr Leu  Asp Asp Ala Ser Glu  Leu Ile Leu Gly Ala  Leu Ile Asp 
    2480                 2485                 2490             


Lys Ile  Ala Ser Arg Ser Gly  Ile Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Asp Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Asp Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Glu Leu Leu Ala Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Arg  Ser Val Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  3
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  3

Met Ser Pro Leu Ile His Glu Asp Gln Pro Tyr Ser Trp Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Val Ile Ala Glu Gly Lys Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Lys Glu Lys Trp Asn His Glu Ala Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Thr His Asn Leu Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Asp Val Leu Tyr Arg Asp Pro Glu Thr Ile Pro Met Phe Gln Cys 
145                 150                 155                 160 


Ser Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Ile Leu Ser His 
    210                 215                 220                 


Glu Gly Leu Ile Thr Met Thr Met Met Arg Leu Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Thr Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Gly Arg Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Glu Pro Leu Leu Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Leu Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Asp Glu Trp Lys Leu Arg Val Pro Leu Gly Val Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Lys Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Tyr Leu 
        435                 440                 445             


Arg Asn His Asn Trp Glu Phe Arg Ser His Thr Arg Lys Ser Gly Ser 
    450                 455                 460                 


Glu Ser Ser Gly Thr Ser Thr Pro Ser Asn Pro Gly Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Lys Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Ile Ala Asp Ser 
            500                 505                 510         


Glu Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Gly Glu Arg Arg Thr 
        515                 520                 525             


Asn His Thr Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Leu Ser Asn Leu Lys Glu Gly Ile Asn Leu Gly Asn Ala Ser Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Asp Gln Tyr Pro Val Phe Lys Glu 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Thr Phe 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Gln 
    610                 615                 620                 


Arg Ala Ile Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Arg Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Met Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Lys Met Ala Glu Arg Ala Thr Val Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Glu Val Val Pro Leu Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Thr Val Leu Asp Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Lys Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Lys Glu Glu Tyr Arg Asn Ala Ile Ser Ser Leu 
    770                 775                 780                 


Lys Val Gln Pro Gly Asn Asp Val Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Ser Ile Thr Gly Leu Gly Pro Asp Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Asp Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Lys Val Ser Pro Val Ser Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Lys Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Ile Lys Tyr Tyr Ser Ala Leu Val Arg Asn Arg 
                885                 890                 895     


Gln Ala Ala Ser Thr Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Glu Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Gly Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Ile Ser Lys Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Glu Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Lys Ile Gln  Gly Asn Ile Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Leu  Lys Ser Ile Pro Thr  Ile Thr Gly Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Ser Ala Leu  Ile Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Thr Leu  Lys Ser Phe Thr Asp  Ser Ile Arg 
    1055                 1060                 1065             


Asn Pro  Ser Asp Val Trp Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Gly Asp  Ser Arg Trp Thr Glu  His Cys Arg Gly Leu  Val Ser Val 
    1085                 1090                 1095             


Val Ala  Pro Asn Lys Val Val  Asn Val Val Asp Ala  Gln Ala Gln 
    1100                 1105                 1110             


Ser Ile  Ala Glu Lys Gln Gly  Phe Ala Glu Leu Val  Ala Ser Trp 
    1115                 1120                 1125             


Glu Thr  Lys Cys Arg Lys Asn  Ile Asn Val Pro Gln  Tyr Tyr Glu 
    1130                 1135                 1140             


Asn Leu  Ile Glu Leu Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Ala  Pro Asn Ala Cys Ile  Gly Asp Leu 
    1160                 1165                 1170             


Glu Ile  Pro Asp Thr Ala Ala  Val Ile Pro Tyr Asn  Trp Gln Phe 
    1175                 1180                 1185             


Pro Phe  Val Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Leu Phe  Ala Ala Leu Ala Thr  Ala Asn Gly Gly Thr  Leu Arg Glu 
    1205                 1210                 1215             


Pro Ala  Val Pro Ile Ser Ala  Ser Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Ile Thr  Ser Lys Pro Gly Glu  Lys Leu Ala Thr Tyr  Ser Ser Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Met Thr Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Ala Phe Glu Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Arg  Asp Leu Thr Cys Ala  Ser Val Ala Arg Glu  Gly Ala Asp 
    1280                 1285                 1290             


Pro Ser  Thr Asp Gly Gln Val  Thr Lys Ala Tyr Asn  Ile Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Ile Asp Leu Met  Ser Gln Ser Glu Ile  Leu Glu Leu 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Asp Gly Asn Thr Asn  Ala Thr Asn 
    1325                 1330                 1335             


Ala Arg  Glu Leu Leu Glu Arg  Ala Ala Tyr Trp Val  Met Lys Arg 
    1340                 1345                 1350             


Ala Val  Ala Gly Tyr Ala Pro  Pro Glu Ser Asn Ser  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Ile  Lys Ser Gln Ser Arg  Val Ala Ser 
    1370                 1375                 1380             


Trp Lys  His Ala Tyr Asp Gly  Trp Asp Gln Leu Phe  Lys Ala Asp 
    1385                 1390                 1395             


Val Glu  Ala Phe Val Asp Arg  Leu Val Ser Ser Ser  Ser Val Gly 
    1400                 1405                 1410             


Lys Phe  Leu Val Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Tyr  Val Asp Asn Thr Gln  Leu Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Asp Leu Leu  Gln His Lys Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Thr Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Ala  Ile Leu Asn Lys Lys  Ser Ser Ala Pro Tyr  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Asp Val  Val Lys Glu 
    1505                 1510                 1515             


Lys Phe  Pro Gln Trp Ala Gln  Leu Ile Gly Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Arg Glu Ile Asn Gly  Gln Glu Asp Ile Glu  Pro Asn Ser 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Met Asn  Asn Val Leu Ala Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Arg  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Val Ala 
    1580                 1585                 1590             


Ser Val  Val Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Ser Asp Arg Ser Asn  Leu Ser Pro Ala Glu  Ile Asp Asp 
    1610                 1615                 1620             


Met Val  Ser Ala Ser Gly Tyr  Ser Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Ser Asn Asn Tyr  Ser Met Met Ile Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Asp Thr Ser Ala  Lys Pro Gln Lys Val  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Glu Ser Thr Ser  Gln Pro Ser Leu Leu  Ala Gly Leu 
    1670                 1675                 1680             


Arg Glu  Glu Gly Ile Glu Val  Thr Val Ser Ser Leu  Ser Glu Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Leu  Cys Ile Val Leu Ser  Asp Leu Ser 
    1700                 1705                 1710             


Asn Lys  Thr Val Leu Ser Asp  Pro Thr Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Lys Ile Met Leu Glu  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Gly Val Thr Thr  Ser Asn Pro Asn Gly  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Val Pro 
    1760                 1765                 1770             


Val Val  Thr Leu Asp Leu Asp  Ala Glu Arg Thr Leu  Asp Asp Ala 
    1775                 1780                 1785             


Val Ser  Thr Asp Ile Ile Leu  Lys Val Phe Arg Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Arg Leu Leu Val Pro  Arg Leu Val Glu Asp  Glu Asp Leu 
    1820                 1825                 1830             


Thr Lys  Thr Leu Ala Ile Ala  Ser Glu Gly Ala Lys  Gly Gln Val 
    1835                 1840                 1845             


Glu Pro  Leu His Gln Pro Gly  Arg Pro Leu Arg Met  Phe Val Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Thr  Ile Phe Trp Thr Asp  Glu Asp Arg 
    1865                 1870                 1875             


Val Asp  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Thr  Gly Phe Asn Phe Lys  Asp Val Met Ile Ala  Leu Gly Gln 
    1895                 1900                 1905             


Val Lys  Val Glu Asn Leu Gly  Trp Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Val Cys  His Ala Ser Gly Thr  Trp Cys Thr Asn Ala  Arg Val His 
    1940                 1945                 1950             


Leu Asp  Asn Val Arg Arg Ile  Pro Asp Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Leu Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Leu  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Asp Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Ile Asp His  Phe His Ile Pro Asp  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Gly Ile  Arg Arg Met 
    2045                 2050                 2055             


Thr Arg  Gly Arg Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Ala  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Leu Gly Ile Asn  Ser Arg Leu 
    2090                 2095                 2100             


Glu Met  Gly Gln Phe Ile Arg  Asn Thr Ser Phe Thr  Ala Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Asn Pro Lys Val Gly  Asn Glu Val 
    2120                 2125                 2130             


Phe Thr  Ser Val Leu Asn Leu  Phe Trp Lys Asp Ala  Ile Lys Gly 
    2135                 2140                 2145             


Pro Thr  Pro Val Glu Val Tyr  Ser Tyr Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Met Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Thr Glu Ala Val  Val Lys Val Ile Pro  Ile Asp Arg 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Ser  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Thr  Gly Val Lys 
    2225                 2230                 2235             


Val Asp  Glu Ala Arg Asp Thr  Ile Arg Val Ile Glu  Glu Met Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Ile Phe Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Glu  Thr Phe Val Gly Asp  Ala Ala Lys Ala Ile  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Phe 
    2285                 2290                 2295             


Glu Lys  Met Ser Met Glu Asp  Tyr Ile Thr Ile Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Trp Asn Leu  His Lys Tyr Val Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Val Ser Gly Ile  Met Gly Asn 
    2330                 2335                 2340             


Ala Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Val Ser  Thr Gln Ser 
    2375                 2380                 2385             


Glu Leu  Lys Gln Ala Met Glu  Arg Gln Gly Phe Glu  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Met Met Ala Leu  Ile Glu Ser Ala Ile  Arg Asn Pro 
    2405                 2410                 2415             


Ala Lys  Pro Ala Gln Gln Ala  His Ile Ile Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Gly Ala Leu Ser Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Leu Ser  Ala Ala Asn Gly Asp  Trp Gly Lys 
    2450                 2455                 2460             


Thr Ala  Thr Gly Asn Asn Leu  Lys Ser Ala Leu Arg  Ala Ala Lys 
    2465                 2470                 2475             


Thr Leu  Asp Asp Ala Ser Glu  Leu Ile Leu Gly Ala  Leu Ile Asp 
    2480                 2485                 2490             


Arg Ile  Ala Ser Arg Ser Gly  Ile Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Asp Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Glu Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Glu Leu Leu Ala Thr  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Arg  Ser Leu Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  4
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  4

Met Ser Pro Leu Ile His Asp Asp Gln Pro Tyr Ser Trp Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Met Ile Ala Glu Gly Arg Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Arg Glu Lys Trp Asn His Glu Ala Trp Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Lys Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Asp Met Leu Trp Arg Asp Pro Glu Thr Val Pro Met Phe Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Ile Leu Ser His 
    210                 215                 220                 


Asp Ala Met Val Thr Met Ser Met Leu Arg Leu Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Val Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Lys Thr Pro Gly Ile Thr Met Pro Ser Ala Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Ala Arg Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Glu Pro Leu Leu Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Leu Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Glu Glu Trp Lys Leu Arg Val Pro Leu Gly Val Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Lys Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Tyr Leu 
        435                 440                 445             


Lys Gln His Asn Phe Glu Phe Arg Ser His Thr Arg Lys Ser Ala Thr 
    450                 455                 460                 


Glu Ser Ser Gly Thr Ser Thr Pro Ser Asn Pro Gly Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Leu Phe Ser Ser Phe Asp Glu Ala Thr Gly Arg Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Trp Ile Glu Asp Arg Leu Gln Leu Ala Asp Ser 
            500                 505                 510         


Glu Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Ala Glu Arg Arg Thr 
        515                 520                 525             


Asn His Thr Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Ile Ser Asn Leu Arg Glu Ala Ile Asn Leu Gly Asn Ala Ser Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Asp Gln Tyr Pro Leu Phe Lys Glu 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Thr Tyr 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Ile Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Lys Met Ala Glu Arg Ala Ser Val Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Glu Val Leu Pro Ile Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Thr Val Leu Asp Asp Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Arg Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Lys Glu Glu Tyr Arg Asn Ala Ile Ser Thr Ile 
    770                 775                 780                 


Lys Ile Gln Pro Ala Asn Asp Val Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Ser Leu Ser Gly Leu Gly Pro Asp Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Asp Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Lys Val Ser Pro Ile Thr Ser Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Lys Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Ile Lys Tyr Tyr Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Ala Ala Ser Thr Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Glu Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Gly Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Ile Ser Arg Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Glu Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Lys Ile Asn  Gly Asn Ile Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Leu  Lys Ser Ile Pro Ser  Ile Thr Ala Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Ser Ala Leu  Ile Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Ser Leu  Lys Ser Phe Thr Asp  Thr Ile Arg 
    1055                 1060                 1065             


Asn Pro  Ser Asp Ile Tyr Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Arg Trp Thr Glu  His Cys Arg Gly Leu  Val Ser Val 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Val  Asn Ile Val Asp Gly  Gln Ala Gln 
    1100                 1105                 1110             


Ser Ile  Ala Glu Lys Gln Gly  Tyr Ala Glu Leu Val  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Thr  Lys Cys Arg Arg Asn  Ile Asn Val Pro Gln  Trp Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Ile Glu Leu Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Gly  Pro Asn Ala Cys Ile  Gly Glu Leu 
    1160                 1165                 1170             


Glu Ile  Pro Asp Thr Ala Ala  Val Met Pro Tyr Asn  Phe Asn Phe 
    1175                 1180                 1185             


Pro Phe  Val Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Ile Phe  Ala Ala Leu Ala Thr  Gly Asn Gly Gly Ser  Leu Lys Asp 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Ser Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Val Thr  Ser Lys Pro Gly Asp  Arg Val Ala Thr Tyr  Thr Ser Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Met Ser Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Ala Phe Glu Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Thr Cys Ala  Thr Leu Ala Arg Glu  Gly Ala Glu 
    1280                 1285                 1290             


Pro Ser  Thr Asp Gly Asn Val  Thr Lys Ala Tyr Asn  Leu Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Ile Asp Leu Leu  Ser Gln Ser Glu Leu  Leu Glu Leu 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Gly Asn Thr Asn  Ala Thr Gln 
    1325                 1330                 1335             


Ala Arg  Glu Ile Leu Glu Lys  Ala Ala Tyr Tyr Met  Ile Arg Arg 
    1340                 1345                 1350             


Ala Val  Ala Gly Tyr Ala Pro  Pro Glu Thr Asn Ser  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Leu  Lys Ser Gln Ser Arg  Val Ala Ser 
    1370                 1375                 1380             


Trp Lys  His Ala Phe Asp Gly  Trp Asp Gln Leu Phe  Lys Ala Asp 
    1385                 1390                 1395             


Val Glu  Ala Phe Ile Asp Lys  Val Val Ser Ser Ser  Ser Leu Gly 
    1400                 1405                 1410             


Lys Phe  Leu Ile Glu Val Gly  Asp Arg Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Gln Thr Gln  Leu Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Asp Leu Leu  Gln His Arg Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Thr Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Asn Lys Lys  Ser Ser Gly Pro Phe  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Val Glu Phe  Asp Ile Arg Glu Val  Val Lys Glu 
    1505                 1510                 1515             


Arg Phe  Pro Gln Trp Ala Gln  Leu Ile Gly Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Lys Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Asn Thr 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Leu Asn  Asn Val Leu Ala Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Val Ala 
    1580                 1585                 1590             


Ser Val  Val Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Ser Asp Arg Ser Asn  Leu Ser Pro Ala Glu  Ile Asp Asp 
    1610                 1615                 1620             


Met Val  Ser Ala Thr Gly Tyr  Thr Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Ser Asn Asn Tyr  Ser Leu Met Val Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Thr  Gln Glu Thr Thr Ala  Lys Pro Gln Lys Ile  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Glu Ser Thr Ser  Gln Pro Ser Leu Leu  Ala Gly Leu 
    1670                 1675                 1680             


Lys Glu  Asp Gly Ile Glu Leu  Thr Ile Ser Ser Leu  Ser Glu Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Val  Cys Ile Val Leu Ser  Asp Ile Ser 
    1700                 1705                 1710             


Asn Arg  Thr Val Leu Ser Asp  Pro Ser Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Lys Ile Val Leu Glu  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Val Thr Thr  Ser Asn Pro Asn Ala  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Val Pro 
    1760                 1765                 1770             


Val Val  Thr Leu Asp Leu Asp  Gly Glu Arg Ser Val  Asp Asp Ala 
    1775                 1780                 1785             


Val Ser  Thr Asp Ile Ile Leu  Lys Val Phe Arg Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Ala Ser Glu  Ile Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Lys Leu Leu Val Pro  Arg Leu Ile Glu Asp  Glu Glu Leu 
    1820                 1825                 1830             


Thr Lys  Thr Leu Ala Ile Ala  Thr Glu Gly Ala Arg  Gly Gln Leu 
    1835                 1840                 1845             


Asp Pro  Leu His Gln Pro Gly  Arg Pro Leu Arg Met  Phe Met Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Ser  Ile Phe Trp Thr Asp  Asp Asp Arg 
    1865                 1870                 1875             


Val Glu  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Met Ala  Leu Gly Gln 
    1895                 1900                 1905             


Met Lys  Val Glu Asn Leu Gly  Trp Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Leu Cys  His Ala Ser Gly Thr  Phe Cys Thr Asn Ala  Arg Val His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Lys Ile  Pro Asp Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Val Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Ile  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Glu Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Ile Asp His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Glu Gln Ser  Phe Ala Ala Gly Ile  Arg Arg Met 
    2045                 2050                 2055             


Thr Arg  Gly Lys Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Ala  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Phe Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Ile Gly Leu Asn  Ser Arg Leu 
    2090                 2095                 2100             


Glu Met  Gly Gln Phe Ile Lys  Asn Thr Ser Phe Thr  Ala Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Asn Pro Lys Val Ala  Asn Glu Met 
    2120                 2125                 2130             


Phe Thr  Ser Val Leu Asn Leu  Phe Trp Lys Asp Ala  Ile Lys Gly 
    2135                 2140                 2145             


Pro Thr  Pro Val Glu Val Tyr  Ser Phe Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Val Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Thr Asp Ala Ile  Val Lys Val Ile Pro  Leu Asp Arg 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Ser  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Lys  Ala Thr Ala Leu Tyr  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Gly Val Lys 
    2225                 2230                 2235             


Val Asp  Glu Ala Arg Glu Thr  Ile Arg Val Leu Glu  Glu Leu Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Ile Phe Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Glu  Thr Phe Val Gly Asp  Ala Ala Lys Ala Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Phe 
    2285                 2290                 2295             


Glu Lys  Met Ser Ile Glu Asp  Tyr Ile Thr Val Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Phe Asn Leu  His Lys Tyr Leu Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Val Ser Gly Ile  Val Gly Asn 
    2330                 2335                 2340             


Gly Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Leu Ser  Thr Asn Ser 
    2375                 2380                 2385             


Glu Leu  Lys Gln Ala Leu Glu  Arg Gln Gly Phe Glu  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Leu Leu Ala Leu  Ile Glu Ser Ala Ile  Arg Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Gly Gln Gln Ala  His Ile Ile Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Gly Ala Leu Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Thr His  Phe Arg His Leu Ser  Ala Gly Asn Ala Asp  Trp Gly Lys 
    2450                 2455                 2460             


Ser Gly  Ser Gly Asn Asn Leu  Lys Ser Ala Leu Lys  Ala Ala Arg 
    2465                 2470                 2475             


Thr Leu  Asp Asp Ala Ser Glu  Leu Ile Leu Gly Ala  Leu Ile Glu 
    2480                 2485                 2490             


Lys Ile  Ala Thr Arg Ser Gly  Ile Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Asp Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Glu Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Glu Leu Leu Gly Ser  Asp Pro Leu Thr His  Leu Ala Ser 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Arg  Ser Val Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  5
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  5

Met Ser Pro Leu Ile His Asp Asp Asn Pro Tyr Thr Trp Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Leu Ile Ala Glu Gly Arg Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Lys Glu Lys Trp Asn His Glu Ala Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Thr Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Glu Leu Leu Phe Arg Asp Pro Glu Thr Leu Pro Met Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Met Leu Ser His 
    210                 215                 220                 


Glu Ala Met Ile Thr Met Ser Met Met Arg Val Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Lys Ser Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Asp Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Ala Arg Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Glu Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Leu Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Glu Glu Trp Arg Leu Arg Val Pro Leu Gly Val Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Lys Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Tyr Leu 
        435                 440                 445             


Arg Asn His Asn Trp Glu Phe Lys Thr His Ser Arg Lys Ser Ala Thr 
    450                 455                 460                 


Glu Ser Ser Gly Thr Ser Thr Pro Ser Asn Pro Gly Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Arg Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Ile Ala Asp Ser 
            500                 505                 510         


Asp Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Gly Glu Arg Arg Thr 
        515                 520                 525             


Asn His Ser Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Leu Ser Asn Leu Arg Glu Ala Ile Asn Leu Gly Asn Ala Ser Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Asp Gln Tyr Pro Val Phe Lys Glu 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Thr Phe 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Ile Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Arg Leu Ala Glu Arg Gly Ser Val Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Glu Val Leu Pro Ile Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Ser Val Leu Asp Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Arg Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Arg Glu Glu Tyr Arg Asn Ala Ile Ser Ser Ile 
    770                 775                 780                 


Lys Val Gln Pro Gly Asn Asp Val Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Ser Ile Ser Gly Leu Gly Pro Asp Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Asp Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Ser Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Arg Leu Ser Pro Ile Ser Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Lys Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Ile Lys Tyr Tyr Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Ala Ala Thr Thr Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Asp Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Ala Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Met Thr Lys Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Lys Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Val Ser Glu Val Pro 
            980                 985                 990         


Trp Val Arg Asp His Arg Ile Gln  Gly Asn Ile Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Val  Lys Ser Ile Pro Thr  Val Thr Gly Tyr Arg  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Ser Ala Leu  Ile Ile Pro Glu Asn  Pro Ala Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Thr Leu  Lys Ser Phe Thr Glu  Ser Ile Lys 
    1055                 1060                 1065             


Asn Pro  Ser Glu Val Trp Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Arg Trp Thr Asp  His Cys Arg Gly Val  Val Ser Val 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Val  Gln Ile Ile Asp Gly  Gln Ala Gln 
    1100                 1105                 1110             


Ser Ile  Ala Glu Lys Gln Gly  Tyr Ala Glu Leu Val  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Thr  Lys Cys Arg Lys Asn  Met Asn Val Pro Gln  Phe Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Leu Glu Val Gly Leu  Glu Tyr Gly Pro Ser  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Gly  Pro Asn Ala Cys Leu  Gly Glu Leu 
    1160                 1165                 1170             


Glu Ile  Pro Asp Thr Ala Gly  Val Met Pro Tyr Asn  Trp Gln Phe 
    1175                 1180                 1185             


Pro Phe  Leu Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Val Phe  Ala Ala Leu Ala Thr  Ala Asn Ala Gly Thr  Ile Lys Glu 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Thr Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Ile Thr  Ser Lys Pro Gly Asp  Lys Leu Ala Thr Tyr  Thr Ser Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Ile Ser Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Ala Phe Glu Pro  Met Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Thr Cys Ala  Thr Leu Gly Arg Glu  Gly Ala Asp 
    1280                 1285                 1290             


Pro Ser  Thr Asp Gly Gln Val  Thr Lys Ala Phe Asn  Ile Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Leu Glu Leu Leu  Ser Asn Ser Glu Ile  Leu Glu Leu 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Gly Asn Thr Asn  Ala Thr Gln 
    1325                 1330                 1335             


Ala Arg  Glu Leu Leu Glu Arg  Ala Ala Tyr Tyr Met  Val Lys Arg 
    1340                 1345                 1350             


Ala Val  Ala Gly Tyr Ala Pro  Pro Glu Thr Asn Thr  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Leu  Arg Ser Gln Ser Lys  Leu Ala Ser 
    1370                 1375                 1380             


Trp Arg  His Ala Tyr Asp Gly  Trp Asp Asn Leu Phe  Lys Ala Asp 
    1385                 1390                 1395             


Val Asp  Ala Phe Ile Asp Lys  Val Val Ser Ser Ser  Ser Val Gly 
    1400                 1405                 1410             


Lys Phe  Leu Val Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Arg Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Asn Thr Gln  Leu Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Asp Leu Leu  Gln His Lys Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Ser Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Ala  Ile Leu Asn Lys Lys  Ser Ser Ala Pro Phe  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Asp Val  Val Lys Glu 
    1505                 1510                 1515             


Arg Phe  Pro Gln Trp Ala Gln  Met Ile Gly Thr Arg  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Arg Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Asn Thr 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Met Asn  Asn Val Leu Ala Gln  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Val Ala 
    1580                 1585                 1590             


Ser Val  Leu Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Ser Gly 
    1595                 1600                 1605             


Ser Thr  Ser Asp Arg Ser Asn  Leu Ser Pro Ala Glu  Ile Asp Asp 
    1610                 1615                 1620             


Met Val  Ser Ala Ser Gly Tyr  Ser Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Ser Asn Asn Tyr  Ser Met Met Val Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Thr  Gln Asp Thr Ser Ala  Lys Pro Gln Arg Val  His Val Ile 
    1655                 1660                 1665             


Gly Glu  Asp Glu Thr Thr Ser  Gln Pro Ser Leu Met  Ala Gly Leu 
    1670                 1675                 1680             


Arg Glu  Glu Gly Ile Glu Val  Thr Val Ser Ser Leu  Ser Glu Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Met  Cys Ile Val Leu Ser  Asp Val Ser 
    1700                 1705                 1710             


Asn Lys  Thr Val Leu Ser Asp  Pro Ser Val Gln Glu  Trp Glu Gly 
    1715                 1720                 1725             


Leu Lys  Lys Ile Ile Leu Glu  Ala Arg Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Met Ser Ser  Thr Asn Pro Asn Ala  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Val Pro 
    1760                 1765                 1770             


Val Val  Thr Leu Asp Leu Asp  Ala Glu Arg Thr Leu  Asp Asp Ala 
    1775                 1780                 1785             


Val Ser  Thr Asp Val Ile Leu  Arg Val Phe Lys Lys  Ser Phe Phe 
    1790                 1795                 1800             


Pro Ala  Phe Thr Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Arg Leu Leu Val Pro  Arg Leu Ile Glu Asp  Glu Glu Ile 
    1820                 1825                 1830             


Thr Arg  Thr Leu Ala Ile Ala  Thr Glu Gly Ala Lys  Gly Gln Met 
    1835                 1840                 1845             


Glu Pro  Ile His Gln Pro Gly  Arg Pro Leu Arg Met  Phe Ile Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Ser  Ile Phe Trp Thr Asp  Asp Asp Arg 
    1865                 1870                 1875             


Val Glu  Ser Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Val Ala  Leu Gly Gln 
    1895                 1900                 1905             


Ile Arg  Val Glu Asn Met Gly  Tyr Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Val Cys  His Ala Ser Gly Thr  Phe Cys Thr Asn Ala  Lys Val His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Lys Ile  Pro Asp Ser Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Leu Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Arg Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Met  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Asp Lys 
    2015                 2020                 2025             


Arg Lys  Phe Leu Ile Glu His  Phe His Ile Pro Glu  Glu His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Gly Ile  Lys Arg Ile 
    2045                 2050                 2055             


Thr Arg  Gly Lys Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Leu Gly Val Asn  Ser Arg Leu 
    2090                 2095                 2100             


Glu Met  Gly Gln Phe Leu Lys  Asn Thr Ser Phe Thr  Gly Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Asn Pro Lys Val Ala  Asn Glu Val 
    2120                 2125                 2130             


Phe Thr  Ser Val Leu Asn Leu  Phe Phe Arg Asp Ala  Ile Lys Gly 
    2135                 2140                 2145             


Pro Ser  Pro Ile Glu Val Tyr  Ser Tyr Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Ser Gly  Gly His Ile Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Ser Ala  Asp Thr Asp Ala Met  Val Lys Val Ile Pro  Leu Asp Arg 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Thr  Asp Ala Thr Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Tyr  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Gly Leu Lys 
    2225                 2230                 2235             


Val Asp  Glu Ala Arg Glu Thr  Ile Lys Leu Leu Glu  Glu Leu Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Ile Phe Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Asp  Thr Phe Val Ala Glu  Ala Ala Lys Ala Leu  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Phe 
    2285                 2290                 2295             


Glu Arg  Leu Ser Leu Glu Asp  Phe Leu Thr Val Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Phe Asn Leu  His Lys Tyr Leu Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Val Ser Gly Leu  Ile Gly Asn 
    2330                 2335                 2340             


Ala Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Leu Gly Phe Leu Thr  Thr Asn Ser 
    2375                 2380                 2385             


Glu Val  Lys Gln Ala Met Glu  Arg Gln Gly Phe Asp  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Leu Met Ala Leu  Ile Glu Ser Ala Ile  Arg Gln Pro 
    2405                 2410                 2415             


Ala Arg  Pro Gly Asn Gln Ala  His Val Ile Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Phe Asn  Glu Asp Ser Ser Leu  Gly Ala Leu Thr Leu  Pro Val Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Leu Ser  Ala Gly Asn Ala Asp  Trp Ala Lys 
    2450                 2455                 2460             


Ser Gly  Ser Ala Asn Asn Leu  Lys Ser Ala Leu Lys  Ala Ala Lys 
    2465                 2470                 2475             


Thr Ile  Glu Asp Ala Ser Glu  Ile Ile Val Gly Ala  Leu Ile Asp 
    2480                 2485                 2490             


Lys Ile  Ala Ser Arg Ser Gly  Leu Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Asp Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Glu Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Asp Leu Leu Ala Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Lys Ser Arg  Ser Val Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  6
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  6

Met Ser Pro Leu Ile His Asp Glu Gln Pro Tyr Ser Trp Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Val Ile Ala Glu Gly Arg Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Arg Glu Lys Trp Asn His Glu Ala Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Lys Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Asp Met Leu Trp Arg Asp Pro Glu Ser Val Pro Met Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Val Leu Ser His 
    210                 215                 220                 


Glu Gly Met Val Thr Met Ser Met Met Arg Leu Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Lys Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Ile Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Thr Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Ala Arg Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Glu Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Ile Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Asp Glu Trp Lys Leu Arg Val Pro Leu Gly Val Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Arg Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Gln Ala Gln Asp Tyr Leu 
        435                 440                 445             


Lys Asn His Asn Trp Glu Phe Arg Ser His Ser Arg Lys Ser Ala Thr 
    450                 455                 460                 


Asp Ser Ser Gly Ser Ser Thr Pro Ser Asn Pro Gly Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Asp Ala Thr Gly Lys Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Ile Ala Asp Ser 
            500                 505                 510         


Asp Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Gly Glu Arg Arg Ser 
        515                 520                 525             


Asn His Thr Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Val Ser Gln Leu Arg Glu Gly Ile Asn Leu Gly Asn Ala Thr Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Asp Gln Tyr Pro Val Phe Lys Asp 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Ser Phe 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Ile Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Asp Asp Ala Met Val Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Lys Met Ala Glu Arg Ala Thr Val Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Asp Val Leu Pro Leu Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Thr Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Glu Glu Leu His Thr Val Leu Asp Asp Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Lys Leu Val Val Asp Met Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Lys Asp Glu Tyr Arg Asn Ala Ile Ser Ser Leu 
    770                 775                 780                 


Lys Val Gln Pro Gly Asn Asp Val Glu Phe Trp Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Thr Ile Ser Gly Leu Gly Pro Asp Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Asp Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Lys Val Ser Pro Val Ser Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Arg Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Ile Lys Tyr Tyr Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Ala Ala Thr Thr Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Asp Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Gly Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Val Asp Leu Pro Pro Tyr Ala Trp Asn His Gly 
    930                 935                 940                 


Gln Ser Tyr Trp Ala Glu Ser Arg Ile Ser Lys Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Glu Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Lys Ile Gln  Gly Gln Met Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Val  Lys Ser Ile Pro Ser  Ile Thr Gly Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Ser Ala Leu  Val Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Thr Leu  Lys Ser Phe Thr Asp  Ser Ile Arg 
    1055                 1060                 1065             


Asn Pro  Ser Asp Met Trp Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Arg Trp Thr Glu  His Cys Arg Gly Leu  Val Ser Val 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Val  Gln Leu Ile Glu Gly  Gln Ala Gln 
    1100                 1105                 1110             


Ser Ile  Ala Glu Lys Gln Gly  Phe Ala Glu Leu Leu  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Ser  Lys Cys Arg Arg Gln  Ile Asn Val Pro Gln  Phe Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Ile Glu Leu Gly Leu  Glu Tyr Gly Pro Ser  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Gly  Pro Asn Ala Cys Val  Gly Asp Leu 
    1160                 1165                 1170             


Glu Leu  Pro Asp Thr Ala Ala  Val Met Pro Tyr Asn  Trp Gln Phe 
    1175                 1180                 1185             


Pro Phe  Leu Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Ile Trp  Ala Ala Ile Ala Ser  Ala Asn Gly Gly Thr  Val Lys Asp 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Ser Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Ile Ser  Thr Lys Pro Gly Asp  Lys Leu Ala Thr Tyr  Ser Ser Ser 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Met Ser Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Arg Gln Gln  Gly Ala Tyr Glu Pro  Met Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Thr Cys Ala  Thr Leu Ala Arg Glu  Gly Ala Asp 
    1280                 1285                 1290             


Pro Ser  Thr Asp Ala Gln Val  Thr Lys Ala Tyr Asn  Leu Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Val Asp Leu Leu  Ser Asn Ser Glu Ile  Val Asp Leu 
    1310                 1315                 1320             


Cys Ala  Lys Thr Thr Ser Pro  Glu Gly Asn Thr Asn  Ala Ser Asn 
    1325                 1330                 1335             


Ala Arg  Glu Ile Leu Glu Arg  Ala Ala Tyr Trp Met  Leu Arg Arg 
    1340                 1345                 1350             


Ala Leu  Ala Ala Tyr Ala Pro  Pro Glu Thr Asn Ser  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Met  Arg Ser Gln Ser Arg  Val Ala Ser 
    1370                 1375                 1380             


Trp Lys  His Ala Tyr Asp Gly  Trp Asp Gln Leu Phe  Arg Ala Asp 
    1385                 1390                 1395             


Ile Glu  Ala Phe Val Asp Lys  Val Val Thr Ser Ser  Ser Val Gly 
    1400                 1405                 1410             


Lys Phe  Leu Val Glu Val Gly  Glu Lys Leu Pro Asn  Leu Val Arg 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Tyr  Val Asp Asn Thr Gln  Leu Phe Gln Asn Thr  Asn Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Asp Leu Leu  Gln His Lys Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Ser Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Asn Arg Lys  Ser Ser Ala Pro Phe  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Glu Ile Arg Asp Val  Val Lys Glu 
    1505                 1510                 1515             


Lys Phe  Pro Gln Trp Gly Asn  Leu Ile Gly Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Arg Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Asn Ser 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Met Asn  Asn Val Leu Ala Gln  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Val Ala 
    1580                 1585                 1590             


Ser Val  Ile Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Thr Asp Arg Ser Asn  Met Ser Pro Ala Asp  Ile Glu Asp 
    1610                 1615                 1620             


Met Val  Ser Ala Ser Gly Tyr  Thr Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Thr Asn Asn Tyr  Ser Met Met Val Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Asp Thr Ser Ala  Arg Pro Gln Lys Ile  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Glu Ser Thr Ser  Gln Pro Ser Leu Leu  Gly Gly Leu 
    1670                 1675                 1680             


Lys Glu  Glu Gly Ile Glu Val  Thr Val Thr Ser Leu  Ser Asp Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Met  Cys Ile Val Leu Ser  Asp Leu Ser 
    1700                 1705                 1710             


Asn Lys  Thr Val Leu Ser Asp  Pro Ser Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Arg Ile Ile Leu Glu  Ala Arg Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Leu Thr Thr  Ser Asn Pro Asn Gly  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Thr Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Leu Pro 
    1760                 1765                 1770             


Ile Val  Thr Leu Asp Leu Asp  Ala Asp Arg Thr Leu  Asp Asp Ala 
    1775                 1780                 1785             


Val Ser  Thr Asp Leu Ile Val  Arg Val Phe Arg Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Gly Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Arg Leu Leu Val Pro  Arg Leu Ile Glu Asp  Glu Glu Val 
    1820                 1825                 1830             


Thr Lys  Thr Leu Ala Val Ala  Ser Glu Gly Ala Lys  Ala Asn Val 
    1835                 1840                 1845             


Glu Pro  Leu His Gln Pro Gly  Arg Pro Leu Arg Met  Phe Val Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Ser  Ile Phe Trp Thr Asp  Asp Asp Arg 
    1865                 1870                 1875             


Leu Asp  Thr Pro Leu Pro Glu  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Met Ala  Leu Gly Gln 
    1895                 1900                 1905             


Leu Lys  Val Glu Asn Leu Gly  Tyr Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Val Cys  His Ala Ser Gly Thr  Phe Cys Thr Asn Ala  Arg Val His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Lys Ile  Pro Asp Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Ile Thr  Tyr Val Thr Ala Trp  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Ile  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Glu Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Ile Asp His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Gly Ile  Arg Arg Val 
    2045                 2050                 2055             


Thr Arg  Gly Arg Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Val Gly Ile Asn  Ser Arg Leu 
    2090                 2095                 2100             


Glu Met  Gly Gln Phe Ile Lys  Asn Thr Ser Phe Thr  Gly Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Asn Pro Lys Val Ala  Asn Asp Val 
    2120                 2125                 2130             


Phe Thr  Ser Val Met Asn Leu  Tyr Trp Arg Asp Ala  Ile Lys Gly 
    2135                 2140                 2145             


Pro Thr  Pro Val Glu Val Tyr  Ser Phe Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Ile Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Thr Glu Ala Leu  Leu Lys Val Val Pro  Leu Asp Lys 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Ser  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Gly Val Lys 
    2225                 2230                 2235             


Val Asp  Glu Ala Arg Glu Thr  Leu Arg Val Ile Glu  Glu Met Glu 
    2240                 2245                 2250             


Cys Arg  Thr Ala Ile Tyr Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Asp  Thr Phe Val Gly Asp  Ala Ala Lys Ala Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Phe 
    2285                 2290                 2295             


Glu Lys  Met Ser Leu Glu Asp  Tyr Met Thr Ile Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Trp Asn Leu  His Lys Tyr Leu Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Leu Glu Ser  Ser Val Ser Gly Ile  Val Gly Asn 
    2330                 2335                 2340             


Ala Ser  Asn Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Val Ser  Thr Asn Ser 
    2375                 2380                 2385             


Glu Val  Lys Gln Ala Leu Glu  Arg Asn Gly Phe Glu  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Leu Met Ala Leu  Ile Glu Ser Gly Ile  Lys Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Gly Gln Gln Gly  His Val Ile Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Ala Ala Leu Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Leu Ser  Ala Gly Asn Ala Asp  Trp Gly Lys 
    2450                 2455                 2460             


Ser Gly  Ser Gly Asn Asn Leu  Arg Ser Ala Leu Lys  Ala Ala Lys 
    2465                 2470                 2475             


Thr Leu  Glu Asp Ala Ser Asp  Leu Ile Leu Gly Ala  Leu Ile Asp 
    2480                 2485                 2490             


Lys Ile  Ala Ser Arg Ser Gly  Leu Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Thr Lys  Ser Met Pro Glu Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Asp Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Glu Leu Leu Ala Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Arg Ile  Ala Gln Arg Ser Arg  Ser Val Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  7
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  7

Met Ser Pro Leu Ile His Asp Asp Gln Pro Tyr Ser Trp Asn Gly Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Met Ile Ala Glu Gly Arg Glu Thr 
        35                  40                  45              


Arg Ile Asp Ile Pro Lys Glu Lys Trp Asn His Glu Ala Phe Phe His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Ser His Asn Met Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Ile His Asp Phe 
        115                 120                 125             


Val Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Glu Val Leu Trp Lys Asp Pro Glu Thr Val Pro Leu Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Arg Gly Pro Ser Ile Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Ile Leu Ser His 
    210                 215                 220                 


Asp Gly Met Val Ser Met Ser Met Met Arg Leu Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Ser Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Thr Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Ala Arg Val Phe Glu Pro Ala Arg Pro Arg Asp 
            340                 345                 350         


Glu Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Leu Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Asp Glu Trp Lys Leu Lys Val Pro Leu Gly Leu Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Lys Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Gln Ala Gln Glu Tyr Leu 
        435                 440                 445             


Arg Asn His Asn Trp Glu Phe Arg Ser His Thr Arg Lys Ser Gly Thr 
    450                 455                 460                 


Glu Thr Ser Ala Thr Thr Thr Pro Ser Asn Pro Ala Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Lys Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Ile Ala Asp Thr 
            500                 505                 510         


Glu Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Gly Glu Arg Arg Ser 
        515                 520                 525             


Asn His Thr Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Ile Ser Asn Leu Arg Glu Gly Ile Asn Leu Ala Asn Ala Ser Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Asp Leu Ile Asp Asn Tyr Pro Val Phe Lys Glu 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Thr Trp 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Gln 
    610                 615                 620                 


Arg Ala Ile Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Arg Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Met Val Ser Ser 
        675                 680                 685             


Arg Met Ala Glu Arg Gly Ser Val Pro Gly Cys Met Met Ala Ile Ala 
    690                 695                 700                 


Met Ser Arg Glu Glu Val Leu Pro Ile Val Ser Thr Leu Ser Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Glu Asp Leu His Thr Val Leu Asp Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Lys Leu Val Val Asp Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Asp Leu Val Arg Asp Glu Tyr Arg Asn Ala Ile Ser Ser Ile 
    770                 775                 780                 


Lys Val Gln Pro Gly Asn Glu Val Glu Phe Tyr Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Thr Ile Ser Gly Leu Gly Pro Glu Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Glu Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Lys Arg 
        835                 840                 845             


Lys Ala Lys Val Ser Pro Val Ser Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Arg Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Ile Lys Tyr Tyr Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Ala Ala Thr Ser Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Asp Pro Ser Leu Glu Lys Val Asn Arg Pro Ser Gly Leu Asp 
        915                 920                 925             


Ser His Ser Leu Leu Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Leu Ser Arg Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Glu Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Arg Ile Gln  Gly Asn Val Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Ile  Lys Ser Ile Pro Ser  Leu Thr Gly Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Glu Thr Ala Leu  Leu Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Ile Asp  Val Ala Ile Ser Leu  Lys Ser Phe Ser Asp  Ser Ile Arg 
    1055                 1060                 1065             


Asn Pro  Thr Glu Ile Trp Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Arg Trp Thr Glu  His Cys Arg Gly Leu  Val Ser Val 
    1085                 1090                 1095             


Leu Ala  Pro Gln Lys Leu Val  Asn Val Leu Asp Gly  Gln Ala Gln 
    1100                 1105                 1110             


Ser Val  Ala Glu Lys Gln Ala  Tyr Ala Asp Leu Val  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Ser  Lys Cys Arg Arg Asn  Ile Asn Leu Pro Gln  Trp Tyr Glu 
    1130                 1135                 1140             


Asn Leu  Ile Glu Leu Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Ala  Pro Asn Ala Cys Ile  Gly Glu Leu 
    1160                 1165                 1170             


Glu Ile  Pro Asp Thr Ala Ala  Leu Met Pro Tyr Asn  Tyr Gln Phe 
    1175                 1180                 1185             


Pro Phe  Val Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Leu Phe  Ala Ala Leu Ala Thr  Ala Asn Ala Gly Thr  Leu Lys Asp 
    1205                 1210                 1215             


Pro Gly  Val Pro Val Ser Ala  Ser Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Val Thr  Thr Lys Pro Gly Asp  Lys Leu Ala Thr Tyr  Thr Ser Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Val Ser Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Ala Phe Asp Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Thr Cys Ala  Thr Leu Ala Arg Asp  Ala Ala Asp 
    1280                 1285                 1290             


Pro Ser  Ser Glu Gly Gln Leu  Thr Lys Gly Tyr Gln  Leu Ala Trp 
    1295                 1300                 1305             


Lys Pro  Thr Ile Asp Leu Leu  Thr Gln Ser Glu Ile  Val Asp Met 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Gly Asn Thr Asn  Ala Thr Asn 
    1325                 1330                 1335             


Ala Arg  Glu Leu Leu Glu Arg  Ala Ala Phe Tyr Met  Leu Lys Arg 
    1340                 1345                 1350             


Ala Met  Ala Gly Tyr Ala Pro  Pro Glu Thr Asn Ser  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Met  Arg Thr Gln Ser Lys  Val Ala Ser 
    1370                 1375                 1380             


Trp Lys  His Ala Tyr Asp Gly  Trp Asp Gln Leu Phe  Arg Ala Asp 
    1385                 1390                 1395             


Leu Asp  Ala Phe Ile Asp Lys  Val Val Ser Ser Ser  Ser Val Ala 
    1400                 1405                 1410             


Lys Phe  Leu Val Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Thr Thr Ala Asp  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Asn Thr Gln  Leu Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Phe Phe Asp Leu Leu  Gln His Arg Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Ser Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Asn Lys Lys  Ser Ser Ala Pro Phe  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Glu Ile Arg Glu Val  Val Lys Glu 
    1505                 1510                 1515             


Lys Phe  Pro Gln Trp Ala Gln  Leu Ile Gly Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Lys Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Asn Ser 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Ser Gly 
    1550                 1555                 1560             


Leu Asn  Gln Val Leu Ala Gln  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Arg  Val Leu Phe Leu Gly  Arg Pro Leu Lys Ser  Ile Leu Ala 
    1580                 1585                 1590             


Ser Val  Met Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Thr Asp Arg Ser Asn  Ile Ser Pro Ala Glu  Ile Glu Asp 
    1610                 1615                 1620             


Leu Val  Thr Ala Ser Gly Tyr  Ser Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Val  Asn Ser Asn Asn Tyr  Ser Met Val Leu Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Asp Thr Ser Ala  Lys Pro Gln Arg Ile  His Val Ile 
    1655                 1660                 1665             


Ala Asp  Asp Glu Ser Thr Ser  Gln Pro Ser Leu Leu  Ala Gly Leu 
    1670                 1675                 1680             


Lys Glu  Glu Gly Ile Asp Ile  Ser Val Ser Ser Leu  Ser Glu Ala 
    1685                 1690                 1695             


Thr Pro  Thr Pro Asp His Val  Cys Ile Val Leu Thr  Asp Leu Ser 
    1700                 1705                 1710             


Gln Lys  Thr Leu Leu Ser Asp  Pro Ser Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Arg Ile Met Leu Glu  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Ile Thr Thr  Thr Asn Pro Asn Gly  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Val Pro 
    1760                 1765                 1770             


Ile Val  Thr Leu Asp Leu Asp  Ala Asp Arg Ser Leu  Asp Asp Ala 
    1775                 1780                 1785             


Leu Ser  Thr Glu Ile Ile Val  Lys Ile Phe Arg Lys  Thr Trp Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Lys Ile Leu Val Pro  Arg Leu Val Glu Asp  Glu Asp Leu 
    1820                 1825                 1830             


Thr Lys  Thr Leu Ala Val Gly  Thr Glu Gly Ala Lys  Ala Gln Leu 
    1835                 1840                 1845             


Glu Pro  Leu His Asn Pro Gly  Arg Pro Leu Lys Met  Phe Ile Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Ser  Ile Phe Trp Thr Asp  Asp Asp Arg 
    1865                 1870                 1875             


Leu Glu  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Thr  Gly Phe Asn Phe Lys  Asp Val Met Val Ala  Leu Gly Gln 
    1895                 1900                 1905             


Met Lys  Val Glu Asn Leu Gly  Trp Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Val Cys  His Gly Ser Gly Thr  Phe Cys Thr Asn Ala  Arg Leu His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Arg Ile  Pro Asp Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Val Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Phe Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Ile  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Val Asp Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Ile Glu His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Gly Ile  Lys Arg Leu 
    2045                 2050                 2055             


Thr Arg  Gly Arg Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Ala  Leu Arg Leu Ser Trp  Asp Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Ile Gly Ile Asn  Ser Lys Leu 
    2090                 2095                 2100             


Glu Leu  Gly Gln Phe Leu Lys  Asn Thr Ser Phe Thr  Ala Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Asn Tyr  Asn Pro Arg Val Ala  Asn Glu Val 
    2120                 2125                 2130             


Phe Thr  Thr Val Val Asn Leu  Phe Trp Lys Asp Ala  Ile Arg Gly 
    2135                 2140                 2145             


Pro Ser  Pro Val Glu Leu Tyr  Ser Phe Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Ile Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Ser Ala  Asp Thr Glu Ala Val  Val Lys Val Val Pro  Ile Asp Arg 
    2180                 2185                 2190             


Thr Lys  Ser Leu Leu Arg Ser  Asp Ala Thr Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Ile Asn Arg Ser  Gly Leu Lys 
    2225                 2230                 2235             


Val Asp  Asp Ala Lys Glu Thr  Ile Arg Val Leu Glu  Glu Met Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Leu Phe Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Glu  Thr Phe Leu Ala Glu  Ala Ala Lys Ala Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Asp Lys  Ile Ser Leu Glu Asp  Tyr Ile Thr Ile Met  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Ser Phe Asn Leu  His Arg Tyr Leu Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Val Ser Gly Val  Val Gly Asn 
    2330                 2335                 2340             


Gly Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Phe Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Thr Gly  Val Gly Tyr Val Ser  Thr Asn Thr 
    2375                 2380                 2385             


Glu Ile  Arg Gln Ala Val Asp  Arg Asn Gly Phe Glu  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Val Leu Ala Leu  Ile Glu Ser Ala Ile  Arg Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Gly Gln Gln Ala  His Met Val Ser Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Ala Ala Ile Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Leu Ser  Gly Gly Asn Ala Asp  Trp Gly Arg 
    2450                 2455                 2460             


Thr Ala  Ser Gly Asn Asn Val  Lys Ser Ala Leu Lys  Gly Ala Arg 
    2465                 2470                 2475             


Ser Val  Glu Asp Ala Ser Glu  Ile Ile Leu Gly Ala  Leu Ile Glu 
    2480                 2485                 2490             


Lys Ile  Ala Thr Arg Ser Gly  Ile Ala Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Asp Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Asp Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Glu Leu Leu Gly Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Lys  Ser Val Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  8
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  8

Met Ser Pro Leu Leu His Glu Glu Gln Pro Tyr Ser Trp Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Asp Asn Leu Phe Lys Leu Ile Ala Asp Gly Lys Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Lys Glu Lys Trp Asn His Asp Gly Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Lys Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Glu Ile Leu Trp Arg Asp Pro Glu Thr Leu Pro Met Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Ile Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Ile Leu Ser His 
    210                 215                 220                 


Asp Gly Met Val Thr Met Ser Met Leu Arg Leu Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Thr Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Thr Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Gly Lys Val Phe Glu Pro Gly Arg Pro Lys Glu 
            340                 345                 350         


Asp Pro Leu Met Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Val Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Glu Glu Trp Lys Leu Arg Val Pro Leu Gly Val Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Arg Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Tyr Leu 
        435                 440                 445             


Arg Asn His Asn Trp Glu Phe Arg Ser His Thr Arg Lys Ser Ala Thr 
    450                 455                 460                 


Glu Ser Ser Gly Thr Thr Thr Pro Ser Asn Pro Gly Pro His Gly Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Arg Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Glu Arg Leu Asn Ile Ala Asp Ser 
            500                 505                 510         


Glu Glu Phe Leu Glu Asp Leu Ala Tyr Thr Leu Ala Glu Arg Arg Thr 
        515                 520                 525             


Asn His Thr Trp Arg Thr Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Leu Ser Gln Leu Lys Glu Gly Ile Asn Leu Gly Gln Gly Ser Gln Thr 
545                 550                 555                 560 


Arg Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Asp Gln Tyr Pro Val Phe Lys Glu 
            580                 585                 590         


Ser Ile Glu Arg Ala Gly Val Ala Cys Gln Lys Ala Gly Ala Ser Phe 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Asp Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Ile Phe Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Arg Met Ala Glu Arg Gly Thr Val Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Glu Val Leu Pro Ile Val Ser Ser Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Thr Leu Leu Asp Glu Lys 
            740                 745                 750         


Gly Val Tyr Asn Arg Arg Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Lys Asp Glu Tyr Arg Asn Ala Ile Ser Ser Leu 
    770                 775                 780                 


Lys Leu Gln Pro Ala Asn Asp Ile Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Ser Ile Ser Gly Leu Gly Pro Glu Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Glu Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Lys Ile Ser Pro Val Ser Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Lys Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Ser Val Lys Tyr Phe Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Ala Ala Thr Thr Val Leu Gln Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Glu Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Ala Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Thr Arg Val Ser Lys Phe Trp Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Leu Glu Pro Arg Trp Arg Gln His Ile Arg Leu Ser Asp Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Arg Ile Gln  Gly Gln Val Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Val  Lys Ser Ile Pro Ser  Val Ser Gly Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Met  Ile Asp Ser Ala Leu  Ile Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Ser Leu  Lys Ser Phe Thr Glu  Ser Ile Arg 
    1055                 1060                 1065             


Asn Pro  Thr Asp Leu Trp Asp  Glu Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Arg Trp Ser Glu  His Cys Arg Gly Leu  Val Ser Val 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Leu Val  Asn Val Val Asp Gly  Gln Ala Asn 
    1100                 1105                 1110             


Ser Ile  Ala Glu Arg Gln Gly  Trp Ala Glu Leu Val  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Ser  Lys Cys Arg Arg Asn  Ile Asn Val Pro Gln  Phe Tyr Asp 
    1130                 1135                 1140             


Gln Leu  Ile Glu Leu Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Lys Ala Lys Ala Gly  Pro Asn Ala Cys Val  Gly Glu Leu 
    1160                 1165                 1170             


Glu Val  Pro Asp Thr Ala Ala  Val Met Pro Tyr Gln  Phe Asn Phe 
    1175                 1180                 1185             


Pro Phe  Val Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Leu Phe  Ala Ala Leu Ala Ser  Gly Asn Gly Gly Ser  Leu Lys Asp 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Thr Ala  Ser Glu Ile Phe Val  Ser Ala Asn 
    1220                 1225                 1230             


Ile Thr  Ser Arg Pro Ala Asp  Arg Leu Ala Thr Tyr  Ser Thr Thr 
    1235                 1240                 1245             


Glu Gln  Arg Asp Tyr Arg Phe  Val Thr Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Ala Phe Glu Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Arg  Asp Leu Thr Cys Ala  Thr Val Ala Arg Glu  Gly Ala Asp 
    1280                 1285                 1290             


Pro Ser  Thr Glu Ala Gln Val  Thr Lys Ala Phe Asn  Val Ala Trp 
    1295                 1300                 1305             


Lys Pro  Thr Ile Asp Leu Leu  Ser Gln Ser Glu Ile  Leu Glu Val 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Ala Asn Ser Asn  Ala Thr Asn 
    1325                 1330                 1335             


Ala Arg  Glu Val Ile Glu Arg  Ala Ala Tyr Tyr Met  Leu Lys Arg 
    1340                 1345                 1350             


Ala Val  Ala Ala Tyr Ala Pro  Pro Glu Ser Asn Thr  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Thr Phe Leu  Lys Ser Asn Ser Lys  Val Ala Thr 
    1370                 1375                 1380             


Tyr Lys  His Ala Tyr Asp Gly  Trp Asp Gln Leu Phe  Lys Ala Asp 
    1385                 1390                 1395             


Val Asp  Ala Phe Leu Asp Lys  Val Val Ser Ser Ser  Ser Leu Gly 
    1400                 1405                 1410             


Lys Phe  Leu Val Glu Val Gly  Glu Lys Leu Pro Gln  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Arg Glu Leu  Asp Ile Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Gln Ser Gln  Leu Phe Gln Asn Thr  Asn Ser Ala 
    1445                 1450                 1455             


Ala Arg  Trp Phe Asp Leu Leu  Gln His Arg Ser Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Thr Gly Val Ala Ser  Leu Ala Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Gln Lys Lys  Ser Ser Ala Pro Phe  Glu Lys Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Glu Val  Val Lys Glu 
    1505                 1510                 1515             


Lys Phe  Pro Gln Tyr Ala Asn  Leu Ile Gly Thr Arg  Gln Val Asp 
    1520                 1525                 1530             


Leu Ser  Lys Glu Ile Gln Ala  Gln Glu Asp Ile Glu  Pro Asn Thr 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Leu Gln  Gln Val Leu Gly Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Ile Ala 
    1580                 1585                 1590             


Ser Val  Val Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Thr Asp Arg Ser Asn  Ile Ser Pro Ala Glu  Ile Asp Asp 
    1610                 1615                 1620             


Met Val  Ser Ala Ser Gly Tyr  Ser Lys Leu Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Ser Asn Asn Tyr  Ser Ile Met Val Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Asp Thr Ser Ala  Lys Pro Gln Lys Leu  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Glu Glu Ser Ser Ser  Gln Pro Ser Leu Leu  Ala Gly Leu 
    1670                 1675                 1680             


Arg Glu  Glu Gly Ile Glu Val  Thr Ile Ser Ser Leu  Ser Glu Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Val  Cys Ile Val Leu Ser  Asp Val Ser 
    1700                 1705                 1710             


Asn Lys  Thr Val Leu Ser Asp  Pro Thr Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Lys Ile Leu Leu Glu  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Val Ser Thr  Ser Asn Pro Gln Ala  Ser Leu Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Glu Leu Pro 
    1760                 1765                 1770             


Leu Val  Thr Leu Asp Leu Asp  Ala Glu Arg Thr Leu  Asp Asp Ala 
    1775                 1780                 1785             


Ile Ser  Thr Asp Ile Ile Leu  Arg Met Phe Arg Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Lys 
    1805                 1810                 1815             


Lys Gly  Arg Leu Leu Val Pro  Arg Leu Val Glu Asp  Glu Glu Ile 
    1820                 1825                 1830             


Thr Lys  Thr Ile Ala Ile Ala  Thr Glu Gly Ala Arg  Gly Gln Leu 
    1835                 1840                 1845             


Glu Pro  Leu His Gln Pro Gly  Arg Pro Ile Lys Met  Phe Leu Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Asp Ser  Ile Phe Trp Thr Asp  Glu Asp Arg 
    1865                 1870                 1875             


Met Glu  Thr Pro Leu Pro Glu  Asp Trp Val Glu Met  Asp Val Arg 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Met Ala  Met Gly Gln 
    1895                 1900                 1905             


Val Lys  Val Glu Asn Leu Gly  Tyr Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Ser  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Leu Cys  His Ala Ser Gly Thr  Phe Cys Thr Asn Ala  Arg Ile His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Arg Ile  Pro Glu Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Val Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Ile  Gly Ala Asp Ile Phe  Ala Thr Val Gly Thr  Leu Glu Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Ile Glu His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Ala Ile  Lys Arg Met 
    2045                 2050                 2055             


Thr Arg  Gly Lys Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Leu Gly Ile Asn  Thr Lys Leu 
    2090                 2095                 2100             


Asp Met  Gly Gln Phe Leu Lys  Asn Thr Ser Phe Thr  Ala Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Asn Pro Lys Val Gly  Asn Glu Leu 
    2120                 2125                 2130             


Phe Thr  Ser Val Leu Asn Leu  Phe Trp Lys Asp Ala  Ile Arg Gly 
    2135                 2140                 2145             


Pro Ser  Pro Val Glu Val Tyr  Ser Phe Thr Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Met Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Thr Asp Ala Met  Val Lys Val Leu Pro  Leu Asp Lys 
    2180                 2185                 2190             


Ser Lys  Thr Leu Leu Arg Ser  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Ile Asn Arg Ser  Gly Val Lys 
    2225                 2230                 2235             


Val Asp  Glu Ala Arg Glu Thr  Ile Lys Ile Leu Glu  Glu Met Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Leu Tyr Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Glu  Thr Phe Met Gly Glu  Ala Ala Lys Ala Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Leu Leu Arg Asp  Thr Leu Phe 
    2285                 2290                 2295             


Glu Lys  Met Ser Val Glu Asp  Phe Ile Thr Val Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Phe Asn Leu  His Lys Tyr Val Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Val Ser Gly Ile  Val Gly Asn 
    2330                 2335                 2340             


Ala Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Thr Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Ser Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Leu Ser  Thr Asn Ser 
    2375                 2380                 2385             


Glu Ile  Lys Gln Ala Met Glu  Arg Gln Gly Phe Glu  Trp Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Leu Leu Gly Met  Ile Glu Ser Ala Ile  Arg Gln Pro 
    2405                 2410                 2415             


Gly Arg  Pro Gly Asn Gln Ala  His Leu Ile Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Ile  Gly Ala Met Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Ile Ser  Ala Gly Gln Gly Asp  Trp Gly Lys 
    2450                 2455                 2460             


Ser Gly  Thr Gly Asn Asn Met  Arg Ser Ala Leu Arg  Ala Ala Lys 
    2465                 2470                 2475             


Thr Ile  Asp Asp Ala Ser Glu  Ile Ile Leu Gly Ala  Leu Ile Asp 
    2480                 2485                 2490             


Lys Ile  Ala Ser Arg Ser Gly  Leu Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Glu Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Glu Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Met Leu  Glu Leu Leu Gly Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Lys  Ser Val Gln Val Gly  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  9
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  9

Met Ser Pro Val Leu His Glu Asp Gln Pro Phe Thr Trp Asn Ala Ala 
1               5                   10                  15      


Ile Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Ser Asn Val Glu Asn Leu Phe Arg Met Ile Ala Glu Gly Arg Glu Ser 
        35                  40                  45              


Arg Ile Asp Ile Pro Lys Glu Lys Trp Asn His Asp Gly Phe Phe His 
    50                  55                  60                  


Pro Glu Pro Thr Arg Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Thr Asn Thr Ser Val Phe Val Gly Thr Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Ala Asp Val Leu Trp Arg Asp Pro Glu Thr Ile Pro Val Tyr Gln Cys 
145                 150                 155                 160 


Thr Gln Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Leu Tyr Asp Leu Arg Gly Pro Ser Met Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Asn Ser Leu Arg Ser Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Met Val Ser His 
    210                 215                 220                 


Glu Gly Met Met Ser Met Ser Met Met Arg Ile Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Lys Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Thr Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Gly Lys Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Asp Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Leu Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Asp Glu Trp Lys Leu Lys Val Pro Leu Gly Leu Glu Asn 
                405                 410                 415     


Trp Glu Val Ser Arg Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Phe Leu 
        435                 440                 445             


Arg Gln His Gln Trp Asp Phe Lys Thr His Thr Arg Lys Ser Ala Ser 
    450                 455                 460                 


Glu Ser Ser Ala Ser Ser Ser Pro Ser Asn Pro Gly Pro His Ala Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Lys Arg Tyr Leu 
                485                 490                 495     


Gln Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Leu Ala Glu Ser 
            500                 505                 510         


Glu Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Ala Glu Arg Arg Thr 
        515                 520                 525             


Asn His Thr Tyr Arg Thr Ala Val Pro Ala Asn Ser Ala Asp Asp Leu 
    530                 535                 540                 


Leu Ser Gln Leu Arg Glu Gly Ile Asn Leu Gly Asn Gly Ser Gln Thr 
545                 550                 555                 560 


Lys Gln Lys Arg Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Glu Gln Tyr Pro Ile Phe Lys Glu 
            580                 585                 590         


Thr Ile Asp Lys Ala Gly Ile Gly Cys Gln Lys Ala Gly Ala Ser Phe 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Glu Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Leu Phe Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Val Val Ser Ser 
        675                 680                 685             


Lys Met Gly Glu Arg Gly Thr Ile Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Glu Val Leu Pro Ile Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Arg Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Asp Leu His Ser Ile Leu Glu Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Arg Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Asp Leu Val Arg Glu Glu Tyr Arg Gln Ala Ile Ser Ser Ile 
    770                 775                 780                 


Arg Ile Asn Pro Gly Asn Asp Leu Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Glu Arg Ala Ser Met Ser Gly Val Gly Pro Glu Tyr Trp Leu Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Gln Glu Ser Leu Gly Arg Leu Cys Leu 
            820                 825                 830         


Asp Thr Glu Gly Pro Ser Ala Thr Ser Lys Arg Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Gly Lys Ile Ser Pro Val Thr Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Arg Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Arg Ala Ser Leu Arg Trp Tyr Ser Ala Leu Val Arg Asn Arg 
                885                 890                 895     


Asn Gly Ala Thr Thr Val Leu Asn Leu Val Gly Gln Leu Phe Val Ala 
            900                 905                 910         


Gly His Glu Pro Ser Leu Glu Lys Val Asn Arg Pro Ser Gly Leu Glu 
        915                 920                 925             


Ser His Ser Val Leu Leu Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Gly Glu Ser Arg Ile Ser Lys Phe Tyr Arg Glu Arg 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Ile Leu Glu Lys Asn Ser Ser 
                965                 970                 975     


Ser Leu Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Asp Ile Pro 
            980                 985                 990         


Trp Val Arg Asp His Lys Ile Gln  Gly Gln Ile Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Gly Ile 
    1010                 1015                 1020             


Ser Ile  Lys Ser Leu Pro Ser  Met Thr Gly Tyr Lys  Leu Lys Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Thr Ala Leu  Ile Ile Pro Glu Gln  Pro Ala Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Ser Leu  Arg Ser Tyr Ser Asp  Ser Leu Arg 
    1055                 1060                 1065             


Asn Pro  Ser Glu Ile Trp Asp  Asp Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Lys Trp Thr Glu  His Cys Arg Gly Met  Val Ser Ile 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Val  Asn Leu Val Asp Gly  Gln Ala Asn 
    1100                 1105                 1110             


Thr Leu  Ala Glu Lys Gln Ala  Tyr Ala Glu Leu Leu  Gly Ser Tyr 
    1115                 1120                 1125             


Asp Thr  Lys Cys Lys Arg Gln  Ile Asn Met Pro Gln  Trp Tyr Asp 
    1130                 1135                 1140             


Asn Leu  Ile Glu Val Gly Leu  Glu Tyr Gly Pro Ser  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Lys Ala Arg Ala Gly  Pro Asn Ala Cys Ile  Gly Asp Leu 
    1160                 1165                 1170             


Glu Ile  Pro Asp Thr Ala Gly  Met Met Pro Tyr Asn  Phe Gln Phe 
    1175                 1180                 1185             


Pro Phe  Leu Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Val Phe  Ala Ala Leu Gly Ser  Ala Asn Gly Gly Thr  Leu Lys Glu 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Ser Glu Ile Trp Val  Ser Ala Asn 
    1220                 1225                 1230             


Ile Ser  Ser Lys Pro Gly Asp  Arg Leu Ala Thr Trp  Thr Thr Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Arg Phe  Met Thr Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Glu  Thr Gln Arg Gln Gln  Gly Ala Phe Asp Pro  Leu Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Thr Cys Ala  Ser Ile Ala Arg Asp  Ala Ala Asp 
    1280                 1285                 1290             


Pro Ser  Ser Asp Ala Gln Leu  Thr Lys Ala Phe Asn  Leu Ala Trp 
    1295                 1300                 1305             


Arg Pro  Ser Val Asp Val Leu  Ser Gln Ser Asp Val  Leu Glu Val 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Gly Asn Ser Asn  Ala Thr Asn 
    1325                 1330                 1335             


Ala Arg  Glu Leu Leu Glu Arg  Ala Ala Phe Tyr Val  Met Arg Lys 
    1340                 1345                 1350             


Ala Ile  Gly Gly Phe Gly Pro  Pro Glu Ser Asn Ser  Gly Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Val Tyr Thr Phe Leu  Lys Ser Gln Ser Arg  Val Ala Ser 
    1370                 1375                 1380             


Trp Lys  His Ala Tyr Asp Gly  Trp Asp Gln Leu Phe  Lys Ala Glu 
    1385                 1390                 1395             


Val Glu  Ala Phe Met Glu Arg  Val Val Ser Thr Ser  Thr Val Gly 
    1400                 1405                 1410             


Lys Phe  Ile Val Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Glu  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Gln Thr Gln  Met Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Asp Leu Leu  Gln His Lys Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Ser Gly Val Ala Ser  Leu Ala Phe 
    1475                 1480                 1485             


Leu Ala  Val Leu Asn Lys Lys  Ser Ser Ala Pro Tyr  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Glu Val  Val Arg Glu 
    1505                 1510                 1515             


Arg Phe  Pro Asn Tyr Ala Gln  Ile Ile Ala Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Leu Ser  Lys Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Gln Thr 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Tyr  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Met Gln  Gln Val Leu Ala Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Ile Gly  Arg Pro Leu Lys Ser  Leu Leu Ala 
    1580                 1585                 1590             


Ser Leu  Val Phe Gly Tyr Val  Pro Ser Val Leu Ala  Asp Thr Gly 
    1595                 1600                 1605             


Ser Thr  Ser Asp Arg Ser Asn  Leu Ser Pro Ala Asp  Ile Asp Asp 
    1610                 1615                 1620             


Leu Val  Ser Ala Ser Gly Tyr  Thr Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Met  Asn Ser Asn Asn Tyr  Ser Ile Met Ile Val  Ser Ala Thr 
    1640                 1645                 1650             


Ala Thr  Gln Glu Thr Thr Ala  Lys Pro Gln Lys Ile  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Glu Thr Thr Ser  Gln Pro Ser Leu Ile  Ala Gly Leu 
    1670                 1675                 1680             


Lys Glu  Glu Gly Leu Glu Leu  Thr Val Ser Thr Leu  Ser Glu Ala 
    1685                 1690                 1695             


Ser Pro  Thr Pro Asp His Met  Cys Ile Met Leu Thr  Asp Leu Thr 
    1700                 1705                 1710             


Asn Arg  Thr Val Leu Ser Asp  Pro Ser Val Gln Glu  Trp Asp Ala 
    1715                 1720                 1725             


Leu Lys  Lys Ile Met Leu Glu  Ala Arg Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Gly Val Thr Thr  Ser Asn Pro Asn Gly  Ser Leu Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Leu Pro 
    1760                 1765                 1770             


Leu Val  Thr Leu Asp Leu Asp  Ala Glu Lys Ser Ile  Asp Glu Gly 
    1775                 1780                 1785             


Val Ser  Thr Glu Ile Ile Leu  Arg Ile Phe Lys Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Ser Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Lys Leu Leu Val Pro  Arg Leu Val Glu Asp  Asp Asp Met 
    1820                 1825                 1830             


Thr Lys  Thr Val Ala Ile Ala  Thr Glu Gly Ala Lys  Gly Gln Leu 
    1835                 1840                 1845             


Glu Pro  Leu His Gln Pro Ala  Arg Pro Leu Lys Met  Phe Met Gly 
    1850                 1855                 1860             


Ser Pro  Gly Leu Leu Asp Thr  Ile Phe Trp Thr Asp  Asp Glu Lys 
    1865                 1870                 1875             


Val Asp  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Leu Ala  Met Gly Gln 
    1895                 1900                 1905             


Leu Lys  Val Glu Gln Leu Gly  Phe Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Thr  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Ile Cys  His Ala Ser Gly Ser  Phe Cys Thr Asn Ala  Arg Leu His 
    1940                 1945                 1950             


Val Asp  Asn Val Lys Arg Ile  Pro Glu Thr Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Val Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Leu  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Asp Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Met Asp His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Gly Ile  Lys Lys Ile 
    2045                 2050                 2055             


Thr Lys  Gly Arg Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Asp Cys Ile Ala Pro  Tyr Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Ile Gly Leu Asn  Thr Arg Leu 
    2090                 2095                 2100             


Glu Met  Ala Gln Phe Ile Arg  Asn Thr Ser Phe Ser  Gly Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Leu Gln Tyr  Asn Pro Lys Leu Ala  Asn Glu Leu 
    2120                 2125                 2130             


Phe Thr  Ser Val Met Asn Leu  Phe Trp Lys Asp Ala  Ile Lys Gly 
    2135                 2140                 2145             


Pro Ser  Pro Leu Glu Val Tyr  Ser Phe Ser Glu Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Met Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Thr Glu Ala Met  Ile Lys Val Leu Pro  Leu Glu Lys 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Ser  Asp Ala Thr Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Lys  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Leu Asn Arg Ser  Ala Val Arg 
    2225                 2230                 2235             


Val Glu  Glu Ala Arg Asp Thr  Ile Arg Val Leu Glu  Asp Leu Glu 
    2240                 2245                 2250             


Cys Arg  Ser Ala Met Phe Pro  Cys Asp Ile Thr Asn  Asp Asn Gln 
    2255                 2260                 2265             


Val Glu  Thr Phe Val Gly Glu  Ala Ala Lys Ala Leu  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Val Met Arg Asp  Ser Leu Phe 
    2285                 2290                 2295             


Glu Lys  Met Ser Leu Glu Asp  Trp Ile Thr Val Leu  Lys Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Tyr Asn Leu  His Arg Tyr Leu Pro  Lys Asp Met 
    2315                 2320                 2325             


Asp Trp  Phe Ile Met Glu Ser  Ser Val Ser Gly Leu  Ile Gly Asn 
    2330                 2335                 2340             


Ala Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Gly 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Thr Gly  Val Gly Phe Val Ser  Thr Asn Ser 
    2375                 2380                 2385             


Glu Val  Arg Gln Ala Leu Glu  Arg Gln Gly Phe Asp  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Ile Leu Ala Leu  Ile Glu Ser Ala Ile  Arg Asn Pro 
    2405                 2410                 2415             


Gly Arg  Pro Gly Gln Gln Gly  His Val Val Ser Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Ala Ala Ile Ser Val  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Ile Ser  Ala Gly Gln Ala Asp  Trp Ala Lys 
    2450                 2455                 2460             


Ser Gly  Thr Ala Asn Asn Val  Arg Ser Ala Leu Arg  Ala Ala Lys 
    2465                 2470                 2475             


Thr Leu  Glu Asp Gly Ser Glu  Val Ile Leu Ala Ala  Leu Ile Asp 
    2480                 2485                 2490             


Lys Ile  Ala Ser Arg Ser Ala  Val Ala Pro Asp Asn  Ile Asn Thr 
    2495                 2500                 2505             


Thr Lys  Ser Met Pro Glu Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Arg Glu Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Met  Asp Leu Leu Gly Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Lys  Ser Ile Asn Val Gly  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  10
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  10

Met Ser Pro Leu Met His Asp Asp Gln Pro Tyr Ser Trp Gln Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Asn Leu Phe Arg Met Ile Ala Glu Gly Arg Glu Thr 
        35                  40                  45              


Arg Val Glu Ile Pro Lys Glu Lys Trp Asn His Asp Gly Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Ser Arg Phe Gly Thr His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Gly Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Glu Phe 
        115                 120                 125             


Val Gly Ser Gln Thr Ser Val Phe Val Gly Ser Tyr Cys Ala Asp Tyr 
    130                 135                 140                 


Gly Asp Ile Ile Phe Lys Glu Pro Asp Ser Leu Pro Met Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Lys Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Met Tyr Asp Leu Lys Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Ser Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Ile Ile Ser His 
    210                 215                 220                 


Asp Gly Ile Ile Ser Met Thr Met Leu Arg Met Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Arg Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Ile Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Ser Pro Gly Ile Thr Val Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Thr Val Tyr Glu Lys Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Thr Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Ser Ala Leu Ala Lys Val Phe Glu Pro Gly Arg Pro Arg Asp 
            340                 345                 350         


Glu Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Val Ile Leu Pro Asn Arg Asn Phe Gln Arg Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Asp Glu Trp Lys Leu Arg Val Pro Val Gly Leu Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Arg Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Asp Tyr Ile 
        435                 440                 445             


Arg Asn His Asn Trp Glu Phe Arg Thr His Thr Arg Arg Ser Ala Thr 
    450                 455                 460                 


Glu Ser Ser Gly Ser Ser Thr Pro Ser Asn Pro Gly Pro His Ala Lys 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Arg Lys Tyr Leu 
                485                 490                 495     


Asn Ser Phe Glu Lys Tyr Ile Glu Asp Arg Leu Gln Leu Ala Asp Ser 
            500                 505                 510         


Glu Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Ala Glu Arg Arg Ser 
        515                 520                 525             


Asn His Thr Trp Arg Ser Ala Val Pro Ala Gln Ser Ala Glu Glu Leu 
    530                 535                 540                 


Ile Thr Asn Leu Lys Glu Gly Leu Asn Val Gly Asn Gly Ser Gln Thr 
545                 550                 555                 560 


Lys Asn Arg Lys Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Asp Leu Ile Glu Gln Phe Pro Ile Phe Lys Glu 
            580                 585                 590         


Ser Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Ser Tyr 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Val Phe Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Glu Leu Leu Ala Ser Trp Gly Val Arg Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Asp Asp Ala Met Val Val Ser Tyr Ser Arg Gly Leu Val Ser Ser 
        675                 680                 685             


Arg Met Ala Glu Arg Gly Thr Leu Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Arg Glu Asp Val Leu Pro Leu Val Ser Thr Leu Thr Lys Gly 
705                 710                 715                 720 


Arg Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Thr Leu Leu Glu Asp Arg 
            740                 745                 750         


Gly Val Phe Asn Arg Arg Leu Val Val Glu Val Ala Tyr His Ser His 
        755                 760                 765             


His Met Asp Leu Val Lys Glu Asp Tyr Arg Asn Ala Ile Ser Ser Val 
    770                 775                 780                 


Lys Val Gln Pro Gly Asn Asp Ile Glu Phe Phe Ser Ser Val Thr Gly 
785                 790                 795                 800 


Asp Arg Ala Thr Ile Thr Ala Val Gly Pro Asp Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Asn Asp Ser Leu Ala Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Ala Thr Thr Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Lys Ala Arg Val Ser Pro Val Thr Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Gly Gly Pro Ile Lys Gln Ile Ile Gln Ala Asn Glu Thr 
865                 870                 875                 880 


Leu Asn Lys Ala Thr Val Lys Tyr Tyr Ser Ala Leu Val Arg Asn Arg 
                885                 890                 895     


Asn Ala Ala Ser Thr Val Leu Asn Leu Val Gly Gln Leu Phe Leu Ala 
            900                 905                 910         


Gly His Glu Pro Ser Leu Glu Lys Val Asn Arg Pro Thr Gly Leu Asp 
        915                 920                 925             


Ser His Thr Leu Leu Val Asp Leu Pro Pro Tyr Ala Trp Asn His Gly 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Leu Ser Arg Phe Tyr Arg Glu Lys 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Val Val Glu Arg Asn Thr Ser 
                965                 970                 975     


Ser Leu Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Asp Leu Pro 
            980                 985                 990         


Trp Val Arg Asp His Arg Ile Gln  Gly Asn Val Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Asn  His Gly Leu 
    1010                 1015                 1020             


Thr Val  Lys Ser Ile Pro Ser  Ile Thr Gly Tyr Arg  Leu Arg Glu 
    1025                 1030                 1035             


Val Val  Ile Asp Thr Ala Leu  Ile Ile Pro Asp Asn  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Thr Leu  Arg Thr Phe Ser Glu  Ser Leu Arg 
    1055                 1060                 1065             


Asn Pro  Ser Asp Met Trp Asp  Glu Phe Ile Ile Ser  Ser Leu Asn 
    1070                 1075                 1080             


Gly Asp  Ser Lys Trp Thr Asp  His Cys Arg Gly Leu  Val Ser Leu 
    1085                 1090                 1095             


Val Gly  Pro Gln Lys Val Val  Asn Val Val Asp Gly  Gln Ala Gln 
    1100                 1105                 1110             


Ser Leu  Ala Glu Lys Gln Gly  Tyr Ala Asp Leu Val  Ala Ser Tyr 
    1115                 1120                 1125             


Glu Thr  Lys Cys Arg Arg Asn  Leu Asn Val Pro Gln  Phe Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Ile Asp Ile Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Ala  Pro Asn Ala Cys Val  Gly Asp Leu 
    1160                 1165                 1170             


Asp Ile  Pro Glu Ser Ala Ala  Leu Met Pro Phe Asn  Trp Gln Phe 
    1175                 1180                 1185             


Pro Phe  Ile Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Ile Phe  Ala Ala Leu Ala Thr  Ala Gln Gly Ala Thr  Val Arg Asp 
    1205                 1210                 1215             


Pro Gly  Val Pro Val Ser Ala  Ser Glu Ile Phe Val  Ser Gly Asn 
    1220                 1225                 1230             


Ile Thr  Thr Arg Pro Ala Glu  Lys Val Ala Thr Tyr  Ser Thr Ser 
    1235                 1240                 1245             


Glu Asn  Lys Asp Tyr Arg Phe  Leu Thr Ala Ser Met  Ser Val Tyr 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Asn  Gly Ala Phe Glu Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Ser Cys Ala  Thr Ile Ala Arg Asp  Ala Ala Glu 
    1280                 1285                 1290             


Pro Ser  Thr Glu Ala Asn Val  Ser Lys Ala Tyr Asn  Leu Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Ile Asp Leu Leu  Ser Gln Ser Glu Leu  Val Asp Leu 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Gly Gln Thr Gln  Ala Thr Asn 
    1325                 1330                 1335             


Ala Arg  Glu Ile Leu Glu Arg  Ala Ala Tyr Phe Met  Ile Lys Arg 
    1340                 1345                 1350             


Ala Leu  Ala Gly Tyr Ala Pro  Pro Glu Ser Asn Ser  Ala Tyr Ala 
    1355                 1360                 1365             


Gln Gln  Leu Trp Ser Phe Leu  Lys Ser Gln Ser Arg  Leu Ala Thr 
    1370                 1375                 1380             


Trp Lys  His Ala Tyr Asp Gly  Trp Glu Gln Val Phe  Lys Ala Asp 
    1385                 1390                 1395             


Ile Glu  Ala Phe Ile Asp Arg  Val Leu Thr Ser Ser  Ser Val Gly 
    1400                 1405                 1410             


Arg Phe  Ile Val Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Arg 
    1415                 1420                 1425             


Gly Glu  Asn Ser Ser Ala Asp  Phe Ile Arg Asp Leu  Asp Met Lys 
    1430                 1435                 1440             


Val Tyr  Val Glu Asn Ser Gln  Leu Phe Asn Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Trp Phe Asp Leu Leu  Gln His Lys Thr Pro  Thr Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Ser Gly Val Ala Ser  Leu Gly Phe 
    1475                 1480                 1485             


Leu Gly  Met Leu Asn Arg Arg  Ser Ser Ala Pro Phe  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Asp Leu  Val Lys Glu 
    1505                 1510                 1515             


Lys Phe  Pro Gln Phe Ala Asn  Leu Ile Ala Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Met Ser  Lys Glu Ile Asn Gly  Gln Glu Asp Ile Glu  Pro Asn Ser 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Leu Gln  Asn Val Leu Ala Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Leu Gly  Arg Pro Leu Lys Ser  Leu Val Ala 
    1580                 1585                 1590             


Ser Leu  Leu Phe Gly Tyr Val  Pro Ser Val Leu Ala  Asp Thr Gly 
    1595                 1600                 1605             


Ser Thr  Ser Asp Arg Ser Asn  Met Ser Pro Ala Glu  Ile Asp Glu 
    1610                 1615                 1620             


Met Val  Ser Ala Thr Gly Tyr  Ser Lys Ile Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Ile  Asn Ser Asn Gln Tyr  Ser Met Met Leu Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Glu Thr Thr Ala  Arg Pro Gln Lys Ile  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Asp Thr Ser Ser  Gln Pro Ser Leu Leu  Ala Gly Leu 
    1670                 1675                 1680             


Lys Asp  Glu Gly Val Glu Leu  Thr Ile Ser Ser Leu  Thr Asp Ala 
    1685                 1690                 1695             


Ser Pro  Ser Pro Asp His Met  Cys Ile Val Leu Ser  Asp Leu Ser 
    1700                 1705                 1710             


Asn Arg  Thr Leu Leu Ser Asp  Pro Ser Val Gln Glu  Trp Glu Ala 
    1715                 1720                 1725             


Leu Lys  Arg Ile Leu Leu Asp  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Leu Thr Thr  Thr Asn Pro Asn Ala  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Asp Val Pro 
    1760                 1765                 1770             


Val Val  Ser Leu Asp Leu Asp  Gly Asp Arg Thr Leu  Asp Asp Ala 
    1775                 1780                 1785             


Leu Ser  Thr Glu Leu Ile Val  Lys Leu Phe Arg Lys  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Gly  Tyr Ser Ala Ser Glu  Val Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Lys Leu Leu Val Pro  Arg Leu Val Asp Asp  Asp Asp Met 
    1820                 1825                 1830             


Thr Arg  Thr Val Ala Ile Ala  Thr Glu Gly Gly Arg  Gly Gln Leu 
    1835                 1840                 1845             


Glu Pro  Leu His Gln Pro Gly  Arg Pro Leu Arg Met  Phe Ile Gly 
    1850                 1855                 1860             


Ser Pro  Gly Leu Leu Asp Ser  Ile Tyr Trp Thr Asp  Glu Glu Arg 
    1865                 1870                 1875             


Val Glu  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Thr  Gly Phe Asn Phe Lys  Asp Val Met Ile Ala  Val Gly Gln 
    1895                 1900                 1905             


Ile Lys  Val Glu Asn Leu Gly  Phe Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Ser  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Met Cys  His Ala Ser Gly Thr  Phe Cys Thr Asn Ala  Lys Val His 
    1940                 1945                 1950             


Val Asp  Asn Val Lys Lys Ile  Pro Glu Thr Met Ser  Trp Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Leu Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Phe Gln  Ile Ala Arg Leu Gln  Arg Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Ile  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Ile Asp Lys 
    2015                 2020                 2025             


Arg Lys  Phe Leu Met Asp His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Ala Ile  Lys Arg Ile 
    2045                 2050                 2055             


Thr Lys  Gly Lys Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Val Ser Trp  Glu Cys Ile Ala Pro  Phe Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Lys  Asp Ile Gly Ile Asn  Ser Arg Leu 
    2090                 2095                 2100             


Asp Leu  Ala Gln Phe Leu Lys  Asn Thr Ser Phe Thr  Ala Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Val Gln Tyr  Gln Pro Arg Leu Ala  Asn Glu Met 
    2120                 2125                 2130             


Phe Thr  Thr Val Leu Asn Leu  Tyr Trp Lys Asp Ala  Ile Arg Gly 
    2135                 2140                 2145             


Pro Ser  Pro Val Glu Val Tyr  Ser Phe Thr Asp Val  Asp Lys Ala 
    2150                 2155                 2160             


Phe Arg  Lys Met Gln Ser Gly  Gly His Ile Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Glu Thr Glu Ala Ile  Ile Lys Val Val Pro  Met Asp Arg 
    2180                 2185                 2190             


Ser Lys  Ser Leu Leu Arg Thr  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Gly Val Lys 
    2225                 2230                 2235             


Val Glu  Glu Ala Arg Glu Thr  Val Lys Val Leu Glu  Asp Ile Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Val Phe Pro  Cys Asp Ile Thr Asn  Glu Gln Gln 
    2255                 2260                 2265             


Val Glu  Thr Trp Val Ala Asp  Ala Ala Lys Gly Leu  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Val Leu Arg Glu  Thr Leu Trp 
    2285                 2290                 2295             


Glu Lys  Leu Ser Leu Glu Glu  Trp Ile Ser Val Leu  Lys Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Thr Trp Asn Leu  His Arg Tyr Ile Pro  Lys Glu Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Val Glu Ser  Ser Val Ser Gly Leu  Val Gly Asn 
    2330                 2335                 2340             


Ala Thr  Gln Ala Ala Tyr Ala  Ala Gly Asn Ser Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Leu Ser  Thr Asn Ser 
    2375                 2380                 2385             


Asp Ile  Lys Gln Ala Ile Glu  Arg Asn Gly Phe Glu  Tyr Thr Asn 
    2390                 2395                 2400             


Pro Lys  Lys Leu Met Ala Val  Ile Glu Thr Ala Ile  Lys Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Ala Gln Gln Ala  His Leu Leu Thr Gly  Leu Gly Thr 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Met  Ala Ala Leu Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Phe Arg His Val Thr  Ala Ala Asn Ala Asp  Trp Gly Lys 
    2450                 2455                 2460             


Ser Gly  Thr Gly Asn Asn Leu  Arg Ser Ala Leu Lys  Ala Ala Lys 
    2465                 2470                 2475             


Thr Leu  Asp Asp Ala Ser Glu  Val Ile Val Gly Gly  Leu Val Asp 
    2480                 2485                 2490             


Lys Ile  Ala Ser Arg Ser Gly  Val Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Glu Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Asp Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Glu Leu Leu Ala Thr  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Ala Gln Arg Ser Arg  Ser Val Gln Val Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  11
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  11

Met Ser Pro Leu Val His Asp Asp Gln Pro Tyr Ser Tyr Asn Ala Ala 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Glu Gln Leu Phe Arg Leu Ile Ala Glu Gly Lys Glu Thr 
        35                  40                  45              


Arg Ile Glu Ile Pro Lys Glu Lys Trp Asn His Asp Gly Phe Tyr His 
    50                  55                  60                  


Pro Asp Pro Thr Arg Phe Gly Ser His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Lys Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Ala Glu Ala Ala Gly Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Lys Met His Asp Phe 
        115                 120                 125             


Val Gly Thr Asn Thr Ser Val Phe Val Gly Thr Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Gly Glu Leu Leu Trp Arg Asp Pro Asp Ser Leu Pro Ile Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Ala Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Leu Tyr Asp Leu Arg Gly Pro Ser Met Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Leu Gly Cys Gln Ser Leu Arg Thr Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Met Leu Thr His 
    210                 215                 220                 


Asp Gly Met Ile Thr Leu Thr Met Leu Arg Val Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Lys Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Ile Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Lys Ser Pro Gly Ile Thr Met Pro Ser Gly Thr Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Arg Ile Gly Leu Glu Pro Leu Asp Thr 
305                 310                 315                 320 


Ser Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Thr Ala Leu Ala Arg Val Phe Glu Pro Ala Lys Pro Arg Asp 
            340                 345                 350         


Glu Pro Leu Val Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Val Ile Leu Pro Asn Arg Asn Phe Gln Lys Gly Asn Pro Lys 
385                 390                 395                 400 


Ile Leu Phe Glu Glu Trp Arg Leu Arg Val Pro Ile Gly Leu Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Arg Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Asn Ala Gln Glu Tyr Leu 
        435                 440                 445             


Lys Gln His Asn Trp Asp Phe Arg Ser His Ser Arg Arg Ser Ala Thr 
    450                 455                 460                 


Glu Ser Ser Gly Thr Ser Thr Pro Ser Asn Pro Ala Pro His Ala Lys 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Arg Lys Tyr Leu 
                485                 490                 495     


Gln Thr Phe Glu Lys Tyr Ile Asp Glu Arg Leu Gln Val Gly Asp Ser 
            500                 505                 510         


Asp Glu Phe Leu Asp Asp Leu Ala Tyr Thr Leu Gly Glu Arg Arg Thr 
        515                 520                 525             


Asn His Thr Tyr Arg Thr Ala Val Pro Ala Gln Ser Ala Asp Asp Leu 
    530                 535                 540                 


Ile Ser Asn Leu Lys Glu Ala Ile Asn Ile Gly Asn Ala Thr Gln Thr 
545                 550                 555                 560 


Lys Gln Arg Arg Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Asp Leu Ile Glu Gln Tyr Pro Val Phe Lys Asp 
            580                 585                 590         


Ser Ile Asp Arg Ala Gly Ile Ala Cys Gln Lys Ala Gly Gly Ser Trp 
        595                 600                 605             


Asp Leu Glu Thr Glu Leu Arg Lys Asp Pro Lys Glu Ser Ala Ile Gln 
    610                 615                 620                 


Arg Ala Val Phe Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Lys Pro Thr Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Glu Asp Ala Met Leu Val Ser Tyr Thr Arg Gly Leu Val Thr Ser 
        675                 680                 685             


Lys Leu Ala Asp Arg Ala Thr Leu Pro Gly Cys Met Met Ala Ile Ala 
    690                 695                 700                 


Met Ser Arg Glu Glu Val Leu Pro Leu Val Ser Thr Val Ser Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Thr Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Val Pro Ala Ile Glu Glu Leu His Thr Ile Leu Glu Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Arg Leu Val Val Asp Leu Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Arg Asp Glu Tyr Arg Asn Ala Ile Ser Ser Leu 
    770                 775                 780                 


Arg Val Asn Pro Gly Asn Glu Val Glu Phe Tyr Ser Ser Val Thr Gly 
785                 790                 795                 800 


Asp Arg Ala Thr Val Ser Gly Met Gly Pro Glu Tyr Trp Val Ser Asn 
                805                 810                 815     


Met Ile Ala Glu Val Lys Phe Gln Asp Ser Leu Ala Arg Leu Cys Leu 
            820                 825                 830         


Asp Ser Glu Gly Pro Thr Ala Thr Thr Lys Lys Ser Ala Asn Arg Arg 
        835                 840                 845             


Lys Ala Lys Ile Ser Pro Leu Thr Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Arg Gln Ile Ile Gln Gly Asn Glu Ser 
865                 870                 875                 880 


Leu Asn Lys Ala Thr Val Lys Tyr Tyr Ser Ala Leu Val Arg Asn Lys 
                885                 890                 895     


Asn Gly Ala Ser Thr Val Leu Gln Leu Val Gly Gln Leu Phe Leu Gly 
            900                 905                 910         


Gly His Glu Pro Ser Leu Asp Lys Leu Asn Arg Pro Thr Gly Leu Glu 
        915                 920                 925             


Ser His Ser Met Val Leu Glu Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Val Thr Lys Phe Trp Arg Glu Arg 
945                 950                 955                 960 


Lys Tyr Pro Arg Thr Asp Leu Leu Gly Val Leu Glu Lys Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Leu Ser Asp Leu Pro 
            980                 985                 990         


Trp Val Arg Asp His Arg Ile Asn  Gly Asn Val Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Gly Ile 
    1010                 1015                 1020             


Ser Ile  Lys Thr Leu Pro Thr  Val Ser Gly Phe Arg  Leu Lys Glu 
    1025                 1030                 1035             


Val Leu  Ile Asp Ser Ala Leu  Val Ile Pro Asp Gln  Pro Gly Glu 
    1040                 1045                 1050             


Val Glu  Val Ala Ile Ser Leu  Arg Ser Phe Thr Glu  Thr Ile Arg 
    1055                 1060                 1065             


Asn Pro  Ser Asp Leu Trp Asp  Asp Phe Val Ile Ser  Ser Val Asn 
    1070                 1075                 1080             


Ala Asp  Ser Lys Trp Ser Glu  His Cys Arg Gly Val  Val Ser Leu 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Leu  Gln Val Val Glu Ala  Gln Ala Asn 
    1100                 1105                 1110             


Ser Ile  Ala Glu Lys Asn Gly  Phe Ala Glu Ile Leu  Ala Thr Tyr 
    1115                 1120                 1125             


Asp Thr  Arg Cys Arg Lys Asn  Val Asn Ile Pro Gln  Phe Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Leu Glu Val Gly Leu  Glu Tyr Gly Pro Thr  Phe Ala Asn 
    1145                 1150                 1155             


Leu Lys  Arg Ala Lys Ala Gly  Pro Asn Gly Cys Ile  Gly Asp Leu 
    1160                 1165                 1170             


Glu Val  Pro Asp Thr Ala Gly  Leu Leu Pro Tyr Gln  Tyr Gln Phe 
    1175                 1180                 1185             


Pro Tyr  Ile Ile His Pro Ala  Thr Leu Asp Ala Leu  Phe His Thr 
    1190                 1195                 1200             


Val Tyr  Gly Gly Ile Gly Thr  Gly Asn Gly Gly Thr  Val Arg Asp 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Ser Glu Ile Tyr Val  Ser Ala Asn 
    1220                 1225                 1230             


Leu Thr  Ser Lys Pro Ala Asp  Arg Met Ala Thr Tyr  Thr Thr Ser 
    1235                 1240                 1245             


Glu Gln  Arg Asp Tyr Lys Phe  Ile Thr Ala Ser Met  Thr Val Phe 
    1250                 1255                 1260             


His Asp  Thr Gln Arg Gln Gln  Gly Ala Phe Glu Pro  Val Ile Glu 
    1265                 1270                 1275             


Ile Arg  Asp Leu Thr Cys Ala  Ser Val Ala Arg Glu  Gly Ala Asp 
    1280                 1285                 1290             


Pro Ser  Thr Glu Ala Gln Leu  Ser Lys Ala Trp Gln  Val Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Val Asp Leu Met  Thr Asn Ser Glu Leu  Leu Asp Ile 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Ala Asn Ser Asn  Ala Thr Asn 
    1325                 1330                 1335             


Ala Lys  Glu Leu Val Glu Arg  Gly Ala Tyr Phe Met  Ile Arg Lys 
    1340                 1345                 1350             


Ala Ile  Ala Ala Phe Ala Pro  Pro Asp Thr Asn Ser  Gly Phe Ala 
    1355                 1360                 1365             


Gln Gln  Val Trp Ser Phe Met  Arg Ser Gln Ser Arg  Leu Ala Ser 
    1370                 1375                 1380             


Tyr Lys  His Gly Phe Glu Ala  Trp Asp Gln Ile Phe  Lys Gly Asp 
    1385                 1390                 1395             


Val Asp  Ala Phe Met Asp Lys  Ile Val Ser Thr Ser  Ser Val Ala 
    1400                 1405                 1410             


Arg Phe  Leu Leu Glu Val Gly  Asp Lys Leu Pro Asn  Leu Val Arg 
    1415                 1420                 1425             


Gly Glu  Asn Thr Ser Ala Glu  Phe Ile Lys Asp Leu  Asp Met Lys 
    1430                 1435                 1440             


Val Phe  Val Asp Asn Ser Gln  Ile Phe Gln Asn Thr  Gln Thr Ala 
    1445                 1450                 1455             


Ala Lys  Phe Phe Glu Leu Leu  Asn His Arg Thr Pro  Thr Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Thr Gly Val Ala Ser  Leu Ala Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Asn Arg Lys  Ser Thr Ala Pro Phe  Glu Lys Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Glu Val  Val Lys Asp 
    1505                 1510                 1515             


Arg Phe  Pro Gln Tyr Ala Gln  Val Ile Gly Thr Lys  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Lys Glu Ile Gln Ala  Gln Glu Asp Ile Glu  Pro Asn Thr 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Leu Asn  Asn Val Leu Ala Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Arg  Val Leu Phe Leu Gly  Arg Pro Val Lys Ser  Val Ile Ala 
    1580                 1585                 1590             


Ser Leu  Ile Phe Gly Phe Val  Pro Ser Val Leu Ala  Glu Thr Ala 
    1595                 1600                 1605             


Ser Thr  Ser Asp Lys Ser Asn  Ile Thr Pro Ala Glu  Ile Asp Glu 
    1610                 1615                 1620             


Leu Val  Ser Ala Thr Gly Tyr  Ser Lys Val Thr Ala  Ile Ala Thr 
    1625                 1630                 1635             


Ser Val  Asn Thr Asn Gln Phe  Ser Met Ile Ile Val  Ser Ala Ser 
    1640                 1645                 1650             


Ala Ser  Gln Asp Thr Ser Ala  Lys Pro Gln Lys Leu  His Val Ile 
    1655                 1660                 1665             


Ala Glu  Asp Asp Ser Ser Ser  Gln Pro Ser Leu Ile  Ala Gly Leu 
    1670                 1675                 1680             


Arg Glu  Glu Gly Leu Glu Val  Ser Leu Ser Ser Leu  Thr Asp Ala 
    1685                 1690                 1695             


Ser Pro  Ser Pro Asp His Val  Cys Ile Val Leu Ser  Asp Val Ser 
    1700                 1705                 1710             


Asn Lys  Thr Ile Leu Ser Asp  Pro Thr Val Gln Glu  Trp Glu Gly 
    1715                 1720                 1725             


Leu Lys  Lys Ile Val Met Asp  Ala Lys Ala Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Lys Gly  Ser Ala Met Ser Thr  Ser Asn Pro Asn Ala  Ser Met Ala 
    1745                 1750                 1755             


Ser Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Glu Leu Pro 
    1760                 1765                 1770             


Leu Leu  Thr Leu Asp Leu Asp  Ala Glu Arg Ser Leu  Asp Glu Ala 
    1775                 1780                 1785             


Val Ser  Ser Glu Leu Ile Met  Lys Val Phe Arg Lys  Thr Phe Tyr 
    1790                 1795                 1800             


Pro Ala  Phe Thr Gly Ser Asp  Ile Glu Gln Glu Tyr  Ala Glu Arg 
    1805                 1810                 1815             


Lys Gly  Arg Ile Leu Val Pro  Arg Leu Ile Glu Asp  Asp Asp Leu 
    1820                 1825                 1830             


Thr Lys  Ser Met Ala Ile Ala  Ser Glu Gly Gly Arg  Gly Gln Val 
    1835                 1840                 1845             


Asp Pro  Val His Gln Pro Ala  Arg Pro Leu Lys Met  Phe Leu Gly 
    1850                 1855                 1860             


Thr Pro  Gly Leu Leu Glu Thr  Ile Tyr Trp Thr Asp  Asp Glu Lys 
    1865                 1870                 1875             


Val Glu  Ser Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Arg 
    1880                 1885                 1890             


Ala Ser  Gly Phe Asn Phe Lys  Asp Val Met Ile Ala  Met Gly Gln 
    1895                 1900                 1905             


Ile Lys  Val Asp Asn Met Gly  Phe Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Gly Val Thr  Ala Leu Gly Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Val Cys  His Gly Ser Gly Ser  Phe Cys Thr Asn Ala  Arg Leu His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Lys Ile  Pro Asp Ser Met Ser  Phe Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Leu Thr  Tyr Leu Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Lys Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Leu  Gly Ala Asp Ile Phe  Ala Thr Val Gly Thr  Leu Glu Lys 
    2015                 2020                 2025             


Lys Lys  Phe Leu Val Asp His  Phe His Ile Pro Glu  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Thr  Phe Ala Ala Gly Ile  Lys Arg Ile 
    2045                 2050                 2055             


Thr Arg  Gly Arg Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Glu Cys Ile Ala Pro  Phe Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Arg  Asp Ile Gly Val Asn  Thr Arg Leu 
    2090                 2095                 2100             


Glu Leu  Ala Gln Phe Leu Arg  Asn Thr Ser Phe Thr  Gly Phe Asn 
    2105                 2110                 2115             


Leu Ala  Phe Met Ile Gln Tyr  Asn Pro Lys Val Ala  Gln Glu Leu 
    2120                 2125                 2130             


Phe Thr  Ser Val Val Asn Leu  Tyr Trp Lys Asp Gly  Ile Arg Gly 
    2135                 2140                 2145             


Pro Thr  Pro Leu Glu Val Tyr  Ser Phe Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Ser Gly  Ala His Leu Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Ser Ala  Glu Thr Glu Gly Leu  Val Arg Leu Leu Pro  Ile Glu Lys 
    2180                 2185                 2190             


Ser Arg  Ser Ile Leu Arg Ser  Asp Ala Ser Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Lys  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Ala Leu Lys 
    2225                 2230                 2235             


Val Glu  Asp Ala Lys Glu Thr  Val Arg Leu Leu Glu  Glu Leu Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Val Tyr Pro  Cys Asp Ile Thr Asn  Asp Asn Asn 
    2255                 2260                 2265             


Val Asp  Thr Phe Val Ala Asp  Ala Ala Lys Ala Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Val Leu Arg Asp  Thr Ile Phe 
    2285                 2290                 2295             


Asp Lys  Leu Ser Met Glu Asp  Trp Ile Thr Met Leu  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Ser Trp Asn Leu  His Arg Tyr Val Pro  Lys Glu Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Met Glu Ser  Ser Ile Ser Gly Val  Leu Gly Gln 
    2330                 2335                 2340             


Ala Ser  Gln Ala Gly Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Ala 
    2345                 2350                 2355             


Phe Ala  Ser Tyr Arg Val Ser  Gln Gly Leu Pro Ala  Ser Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Val Gly Tyr Ile Thr  Thr Asn Thr 
    2375                 2380                 2385             


Asp Leu  Arg Gln Ala Leu Glu  Arg Gln Gly Phe Asp  Phe Thr Asn 
    2390                 2395                 2400             


Pro Lys  Lys Leu Met Ala Met  Ile Asp Ser Ala Ile  Lys Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Gly Gln Gln Gly  His Val Val Thr Gly  Leu Gly Ser 
    2420                 2425                 2430             


Trp Asn  Glu Asp Ser Ser Leu  Ala Ala Met Thr Leu  Pro Met Phe 
    2435                 2440                 2445             


Ser His  Tyr Arg His Leu Ser  Ala Gly Gln Ala Asp  Trp Ala Lys 
    2450                 2455                 2460             


Ser Gly  Ser Gly Asn Asn Leu  Lys Ser Ala Leu Lys  Gly Ala Lys 
    2465                 2470                 2475             


Ser Met  Asp Asp Ala Ser Asp  Val Ile Leu Gly Ala  Leu Val Asp 
    2480                 2485                 2490             


Arg Ile  Ala Ser Arg Ser Gly  Met Ala Pro Asp Asn  Ile Asn Ser 
    2495                 2500                 2505             


Thr Lys  Ser Met Pro Glu Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Thr  Lys Asp Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Val Leu  Asp Leu Leu Ala Thr  Asp Pro Leu Thr His  Leu Ala Ser 
    2540                 2545                 2550             


Lys Ile  Ala Gln Lys Ser Arg  Ser Val Asn Ile Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  12
<211>  2570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 2

<400>  12

Met Ser Pro Leu Leu His Glu Asp Gln Pro Tyr Thr Trp Asn Ala Gly 
1               5                   10                  15      


Met Pro Ile Ala Val Val Gly Ile Gly Phe Arg Gly Pro Gly Asp Ala 
            20                  25                  30          


Thr Asn Val Asp Asn Leu Phe Arg Met Ile Ala Glu Gly Arg Glu Ser 
        35                  40                  45              


Arg Ile Glu Ile Pro Lys Glu Lys Trp Asn His Glu Gly Tyr Phe His 
    50                  55                  60                  


Pro Glu Pro Ser Lys Phe Gly Ser His Asn Val Thr Gly Gly His Tyr 
65                  70                  75                  80  


Phe Gln Gln Asp Val Ser Arg Phe Asp Ala Pro Phe Phe Asn Met Thr 
                85                  90                  95      


Ala Gly Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Met Leu Leu Glu 
            100                 105                 110         


Cys Thr Tyr Glu Ala Met Glu Asn Ser Gly Thr Arg Met His Glu Phe 
        115                 120                 125             


Leu Gly Ser Asn Thr Ser Val Phe Val Gly Ser Phe Cys Ala Asp Tyr 
    130                 135                 140                 


Gly Asp Met Val Phe Arg Asp Pro Asp Thr Leu Pro Met Tyr Gln Cys 
145                 150                 155                 160 


Thr Asn Gly Gly His Ser Arg Ala Asn Thr Ala Asn Arg Val Ser Tyr 
                165                 170                 175     


Val Tyr Asp Leu Arg Gly Pro Ser Ile Thr Val Asp Thr Ala Cys Ser 
            180                 185                 190         


Ala Ser Leu Val Ala Leu His Ile Gly Cys Gln Ser Leu Arg Ser Gly 
        195                 200                 205             


Asp Ala Lys Gln Ala Leu Val Ala Gly Cys Ser Ala Leu Leu Thr His 
    210                 215                 220                 


Asp Gly Met Ile Ser Leu Ser Leu Met Arg Met Leu Ser Pro Glu Gly 
225                 230                 235                 240 


Lys Cys Tyr Thr Phe Asp Glu Arg Ala Gly Gly Tyr Ala Arg Gly Asp 
                245                 250                 255     


Gly Val Gly Ala Ile Leu Leu Lys Pro Leu Gln Asp Ala Leu Asp Ala 
            260                 265                 270         


Gly Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn Gln Asp 
        275                 280                 285             


Gly Arg Thr Pro Gly Ile Thr Met Pro Ser Ala Ser Ala Gln Glu Ala 
    290                 295                 300                 


Leu Val Arg Ser Val Tyr Glu Arg Ile Gly Leu Asp Pro Leu Asp Thr 
305                 310                 315                 320 


Thr Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp Val Thr 
                325                 330                 335     


Glu Thr Thr Ala Leu Gly Arg Val Phe Glu Pro Gly Arg Pro Lys Asp 
            340                 345                 350         


Asp Pro Leu Leu Ile Gly Ser Val Lys Thr Asn Ile Gly His Leu Glu 
        355                 360                 365             


Gly Ala Ser Gly Val Ala Gly Val Ile Lys Thr Ile Leu Met Leu Glu 
    370                 375                 380                 


Asn Gly Val Ile Leu Pro Asn Arg Asn Phe Gln Arg Gly Asn Pro Arg 
385                 390                 395                 400 


Ile Leu Phe Glu Glu Trp Lys Leu Lys Val Pro Ile Ala Leu Glu Asn 
                405                 410                 415     


Trp Glu Ile Ser Arg Pro Arg Arg Ala Ser Val Asn Ser Phe Gly Tyr 
            420                 425                 430         


Gly Gly Ala Asn Ala His Val Val Leu Glu Gln Ala Gln Asp Tyr Leu 
        435                 440                 445             


Arg Gln His Asn Trp Asp Phe Arg Ser His Ser Arg Lys Ser Ala Ser 
    450                 455                 460                 


Glu Thr Ser Gly Ser Ser Ser Pro Thr Asn Pro Ala Pro His Ala Arg 
465                 470                 475                 480 


Leu Phe Val Phe Ser Ser Phe Asp Glu Ala Thr Gly Lys Lys Tyr Leu 
                485                 490                 495     


Gln Ser Phe Asp Lys Tyr Ile Glu Glu Arg Leu Gln Ile Gly Glu Ser 
            500                 505                 510         


Asp Asp Phe Leu Asp Asp Leu Ala Phe Thr Leu Ala Glu Arg Arg Ser 
        515                 520                 525             


Asn His Thr Tyr Arg Thr Ala Val Pro Ala Gln Ser Ala Asp Asp Leu 
    530                 535                 540                 


Val Ser Asn Leu Arg Glu Gly Leu Asn Leu Ala Asn Gly Ser Gln Thr 
545                 550                 555                 560 


Arg Asn Lys Arg Ile Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp 
                565                 570                 575     


Cys Gly Met Gly Lys Glu Leu Ile Glu Gln Tyr Pro Val Phe Lys Asp 
            580                 585                 590         


Thr Ile Glu Lys Ala Gly Ile Ala Cys Gln Lys Ala Gly Ala Thr Trp 
        595                 600                 605             


Asp Leu Glu Thr Asp Leu Arg Arg Glu Pro Lys Glu Ser Ala Ile Asn 
    610                 615                 620                 


Arg Ala Val Tyr Ser Gln Pro Leu Ser Thr Ala Val Gln Leu Gly Leu 
625                 630                 635                 640 


Ile Asp Leu Leu Ala Ser Trp Gly Val Arg Pro Ser Ser Val Thr Gly 
                645                 650                 655     


His Ser Ser Gly Glu Ile Ala Ser Ala Tyr Ala Ala Gly Ala Leu Ser 
            660                 665                 670         


Leu Asp Asp Ala Met Leu Val Ser Tyr Ser Arg Gly Leu Val Ser Thr 
        675                 680                 685             


Arg Leu Ala Glu Arg Gly Thr Ile Pro Gly Cys Met Met Ala Ile Gly 
    690                 695                 700                 


Met Ser Lys Glu Asp Val Leu Pro Leu Val Ser Ser Leu Thr Lys Gly 
705                 710                 715                 720 


Lys Val Val Val Ala Cys Ser Asn Ser Pro Ser Ser Val Thr Ala Ser 
                725                 730                 735     


Gly Asp Leu Pro Ala Ile Asp Glu Leu His Thr Val Leu Glu Glu Lys 
            740                 745                 750         


Gly Val Phe Asn Arg Arg Leu Val Val Glu Met Ala Tyr His Ser His 
        755                 760                 765             


His Met Glu Leu Val Lys Asp Glu Tyr Arg Gln Ala Ile Ser Ser Ile 
    770                 775                 780                 


Arg Val Gln Pro Gly Asn Asp Val Glu Trp Tyr Ser Ser Val Thr Gly 
785                 790                 795                 800 


Asp Arg Ala Thr Ile Thr Ala Met Gly Pro Glu Tyr Trp Val Thr Asn 
                805                 810                 815     


Met Ile Gly Glu Val Lys Phe Gln Glu Ser Leu Ala Arg Leu Cys Leu 
            820                 825                 830         


Glu Thr Glu Gly Pro Ser Gly Ser Ser Lys Lys Ser Ala Gln Arg Arg 
        835                 840                 845             


Arg Ala Arg Ile Ser Pro Val Thr Thr Leu Ile Glu Ile Gly Pro His 
    850                 855                 860                 


Ser Ala Leu Ala Gly Pro Ile Arg Gln Leu Ile Gln Gly Asn Asp Thr 
865                 870                 875                 880 


Val Asn Lys Ala Thr Val Arg Tyr Tyr Ser Ala Leu Val Arg Asn Arg 
                885                 890                 895     


Asn Ala Ala Ser Ser Val Leu Gln Leu Val Gly Asn Leu Phe Val Gly 
            900                 905                 910         


Gly His Glu Pro Ser Leu Asp Arg Leu Asn Arg Pro Ser Gly Leu Glu 
        915                 920                 925             


Thr His Ser Leu Val Ile Asp Leu Pro Pro Tyr Ala Trp Asn His Ala 
    930                 935                 940                 


Asn Ser Tyr Trp Ala Glu Ser Arg Leu Ser Lys Tyr Phe Arg Glu Lys 
945                 950                 955                 960 


Arg Phe Pro Arg Thr Asp Leu Leu Gly Ile Leu Glu Arg Asn Ser Ser 
                965                 970                 975     


Ser Ile Glu Pro Arg Trp Arg Asn His Ile Arg Val Ser Glu Met Pro 
            980                 985                 990         


Trp Val Arg Asp His Lys Ile Asn  Gly Asn Ile Val Tyr  Pro Ala Ala 
        995                 1000                 1005             


Gly Tyr  Leu Ala Met Ala Ile  Glu Ala Ala Cys Gln  His Ala Ile 
    1010                 1015                 1020             


Thr Val  Lys Thr Val Pro Ser  Leu Ser Gly Tyr Lys  Leu Arg Glu 
    1025                 1030                 1035             


Val Leu  Ile Glu Ser Ala Leu  Val Ile Pro Glu Asn  Pro Gly Glu 
    1040                 1045                 1050             


Ile Glu  Val Ala Ile Thr Leu  Lys Ser Tyr Thr Asp  Ser Ile Arg 
    1055                 1060                 1065             


Gln Pro  Thr Asp Ile Trp Asp  Glu Phe Val Ile Thr  Ser Val Gln 
    1070                 1075                 1080             


Gly Glu  Ser Arg Trp Thr Glu  His Cys Arg Gly Leu  Val Ser Ile 
    1085                 1090                 1095             


Val Ala  Pro Gln Lys Val Val  Asn Val Val Asp Gly  Gln Ala Gln 
    1100                 1105                 1110             


Thr Leu  Ala Asp Arg Asn Ala  Tyr Gly Glu Leu Leu  Gly Ser Phe 
    1115                 1120                 1125             


Asp Ser  Lys Cys Arg Arg Asn  Val Asn Val Pro Gln  Phe Tyr Glu 
    1130                 1135                 1140             


Gln Leu  Ile Glu Ile Gly Leu  Asp Tyr Gly Pro Ser  Phe Ala Asn 
    1145                 1150                 1155             


Leu Arg  Lys Ala Arg Ala Ala  Pro Asn Gly Cys Val  Gly Glu Leu 
    1160                 1165                 1170             


Glu Leu  Pro Asp Thr Ala Ala  Val Met Pro Tyr Gln  Trp Gln Tyr 
    1175                 1180                 1185             


Pro Phe  Leu Ile His Pro Ala  Thr Leu Asp Ala Met  Phe His Ser 
    1190                 1195                 1200             


Leu Phe  Ala Ala Met Ala Ser  Ala Asn Gly Gly Ser  Leu Lys Asp 
    1205                 1210                 1215             


Pro Ala  Val Pro Val Ser Ala  Ser Glu Ile Phe Val  Ser Gly Gln 
    1220                 1225                 1230             


Leu Ser  Thr Arg Pro Ala Glu  Arg Val Ala Thr Tyr  Thr Ser Thr 
    1235                 1240                 1245             


Glu Gln  Lys Asp Tyr Lys Phe  Val Thr Ala Ser Met  Thr Val Trp 
    1250                 1255                 1260             


His Glu  Ser Gln Lys Gln Gln  Gly Gly Phe Glu Pro  Leu Ile Glu 
    1265                 1270                 1275             


Ile Lys  Asp Leu Ser Cys Ala  Ser Ile Gly Arg Glu  Gly Ala Glu 
    1280                 1285                 1290             


Pro Ser  Thr Glu Ala Gln Ile  Ser Arg Ala Trp Asn  Leu Ala Trp 
    1295                 1300                 1305             


Lys Pro  Ser Val Asp Leu Met  Thr Gln Thr Glu Met  Leu Asp Ile 
    1310                 1315                 1320             


Cys Ala  Lys Thr Ser Ser Pro  Glu Ala Gln Thr Gln  Ala Ser Asn 
    1325                 1330                 1335             


Ala Arg  Glu Val Ile Glu Arg  Gly Ala Tyr Phe Met  Ile Arg Lys 
    1340                 1345                 1350             


Ala Val  Ala Ala Tyr Gly Pro  Pro Asp Thr Asn Ser  Gly Phe Ala 
    1355                 1360                 1365             


Gln Gln  Leu Phe Ser Phe Leu  Arg Thr Gln Thr Arg  Ile Ala Thr 
    1370                 1375                 1380             


Phe Lys  His Gly Tyr Asp Gly  Trp Asp Gln Leu Phe  Lys Ala Asp 
    1385                 1390                 1395             


Ile Asp  Gly Phe Val Glu Arg  Leu Val Ser Thr Ser  Ser Ile Ala 
    1400                 1405                 1410             


Arg Phe  Met Val Glu Val Gly  Glu Arg Leu Pro Asn  Leu Val Lys 
    1415                 1420                 1425             


Gly Glu  Asn Thr Ser Ala Glu  Phe Ile Lys Glu Leu  Asp Leu Lys 
    1430                 1435                 1440             


Val Tyr  Val Glu Asn Thr Gln  Leu Phe Gln Asn Thr  Gln Ser Ala 
    1445                 1450                 1455             


Ala Arg  Tyr Phe Glu Leu Leu  Gln His Arg Thr Pro  Ser Leu Ser 
    1460                 1465                 1470             


Val Leu  Ala Val Gly Pro Gly  Thr Gly Val Ala Ser  Val Ala Phe 
    1475                 1480                 1485             


Leu Ala  Leu Leu Gln Lys Arg  Thr Ser Ala Pro Tyr  Glu Arg Tyr 
    1490                 1495                 1500             


Glu His  Asn Asp Ile Glu Phe  Asp Ile Arg Glu Val  Val Lys Glu 
    1505                 1510                 1515             


Arg Phe  Pro Gln Tyr Ala Gln  Val Ile Gly Thr Arg  Gln Val Asp 
    1520                 1525                 1530             


Ile Ser  Arg Glu Ile Gln Gly  Gln Glu Asp Ile Glu  Pro Asn Ser 
    1535                 1540                 1545             


Tyr Asp  Val Leu Val Ala Phe  His Val Leu Gly Asp  Ala Thr Gly 
    1550                 1555                 1560             


Leu Asn  Asn Val Leu Ala Asn  Ser Lys Gln Leu Leu  Lys Pro Asp 
    1565                 1570                 1575             


Gly Lys  Val Leu Phe Leu Gly  Arg Pro Leu Lys Ser  Met Leu Ala 
    1580                 1585                 1590             


Ser Val  Val Phe Gly Tyr Val  Pro Ser Val Leu Ala  Glu Thr Gly 
    1595                 1600                 1605             


Ser Thr  Thr Asp Arg Ser Asn  Leu Ser Pro Gly Glu  Ile Asp Asp 
    1610                 1615                 1620             


Leu Val  Ser Ala Ser Gly Tyr  Ser Lys Val Thr Ala  Val Ala Ser 
    1625                 1630                 1635             


Ser Leu  Asn Thr Gln Asn Tyr  Thr Leu Ile Ile Val  Ser Ala Thr 
    1640                 1645                 1650             


Gly Ser  Asn Glu Thr Ser Ala  Lys Pro Gln Arg Leu  His Val Ile 
    1655                 1660                 1665             


Ala Asp  Asp Glu Thr Thr Thr  Gln Pro Ser Leu Leu  Gly Gly Leu 
    1670                 1675                 1680             


Lys Asp  Glu Gly Val Glu Ile  Ser Val Ser Thr Leu  Ser Asp Ala 
    1685                 1690                 1695             


Ser Pro  Ser Pro Asp His Val  Cys Ile Val Leu Ser  Asp Val Ser 
    1700                 1705                 1710             


Gln Arg  Thr Val Leu Ser Asp  Pro Ser Val Gln Glu  Trp Asp Gly 
    1715                 1720                 1725             


Leu Lys  Lys Ile Ile Leu Glu  Ala Lys Gly Val Leu  Trp Val Thr 
    1730                 1735                 1740             


Arg Gly  Ser Ala Leu Thr Ser  Thr Asn Pro Asn Gly  Ser Met Ala 
    1745                 1750                 1755             


Thr Gly  Leu Ser Arg Thr Ile  Arg Ser Glu Arg Gly  Glu Val Pro 
    1760                 1765                 1770             


Ile Val  Ser Leu Asp Leu Asp  Ala Glu Lys Ser Leu  Glu Asp Ala 
    1775                 1780                 1785             


Val Thr  Ser Asp Ile Ile Leu  Lys Met Phe Arg Arg  Ser Phe Tyr 
    1790                 1795                 1800             


Pro Gly  Phe Ser Ala Thr Glu  Ile Glu Gln Glu Tyr  Ala Glu Lys 
    1805                 1810                 1815             


Lys Gly  Lys Val Leu Val Pro  Arg Leu Val Glu Asp  Glu Glu Met 
    1820                 1825                 1830             


Thr Lys  Ser Val Ala Ile Ala  Thr Glu Ala Ala Lys  Ala Gln Leu 
    1835                 1840                 1845             


Glu Pro  Val His Asn Pro Gly  Arg Pro Leu Arg Met  Phe Leu Ala 
    1850                 1855                 1860             


Ser Pro  Gly Val Leu Asp Ser  Ile Phe Trp Thr Asp  Asp Glu Arg 
    1865                 1870                 1875             


Val Asp  Thr Pro Leu Pro Asp  Asp Trp Val Glu Met  Glu Val Lys 
    1880                 1885                 1890             


Ala Thr  Gly Phe Asn Phe Lys  Asp Val Met Leu Ala  Leu Gly Gln 
    1895                 1900                 1905             


Leu Lys  Val Glu Asn Leu Gly  Trp Glu Cys Ser Gly  Ile Leu Thr 
    1910                 1915                 1920             


Lys Val  Gly Pro Ala Val Ser  Gly Leu Ala Val Gly  Asp Arg Val 
    1925                 1930                 1935             


Ile Cys  His Ala Thr Gly Ser  Phe Cys Thr Asn Ala  Arg Val His 
    1940                 1945                 1950             


Val Asp  Asn Val Arg Arg Ile  Pro Asp Ser Met Ser  Tyr Glu Ile 
    1955                 1960                 1965             


Ala Ala  Ser Leu Pro Val Thr  Tyr Val Thr Ala Tyr  His Ser Ile 
    1970                 1975                 1980             


Tyr Asn  Ile Ala Arg Leu Gln  Arg Gly Glu Thr Ile  Leu Val His 
    1985                 1990                 1995             


Ala Ala  Thr Gly Gly Leu Gly  Gln Ala Ile Ile Glu  Leu Cys Gln 
    2000                 2005                 2010             


Leu Leu  Gly Ala Glu Ile Phe  Ala Thr Val Gly Thr  Leu Asp Lys 
    2015                 2020                 2025             


Arg Lys  Phe Leu Met Glu His  Phe His Ile Pro Asp  Asp His Ile 
    2030                 2035                 2040             


Phe Phe  Ser Arg Asp Gln Ser  Phe Ala Ala Ala Ile  Arg Lys Ile 
    2045                 2050                 2055             


Thr Arg  Gly Arg Gly Val Asp  Ala Val Met Asn Ser  Leu Ala Gly 
    2060                 2065                 2070             


Glu Gly  Leu Arg Leu Ser Trp  Asp Cys Ile Ala Pro  Phe Gly Arg 
    2075                 2080                 2085             


Phe Val  Glu Leu Gly Gln Lys  Asp Ile Gly Ile Asn  Thr Lys Leu 
    2090                 2095                 2100             


Glu Leu  Gly Gln Phe Leu Arg  Asn Ser Ser Phe Thr  Gly Phe Asn 
    2105                 2110                 2115             


Leu Ala  Tyr Met Leu Gln Tyr  Gln Pro Lys Leu Ala  Gln Glu Ile 
    2120                 2125                 2130             


Phe Thr  Ser Val Met Gln Leu  Tyr Trp Lys Asp Ala  Ile Arg Gly 
    2135                 2140                 2145             


Pro Ser  Pro Leu Glu Val Tyr  Ser Phe Ser Asp Val  Glu Lys Ala 
    2150                 2155                 2160             


Phe Arg  Arg Met Gln Thr Gly  Gly His Ile Gly Lys  Leu Val Gly 
    2165                 2170                 2175             


Thr Ala  Asp Ser Asp Ala Leu  Ile Lys Val Ile Pro  Val Glu Lys 
    2180                 2185                 2190             


Thr Lys  Thr Val Leu Arg Ser  Glu Ala Thr Tyr Val  Leu Ile Gly 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ile Gly Arg  Ala Thr Ala Leu Trp  Met Val Glu 
    2210                 2215                 2220             


His Gly  Ala Arg Asn Val Ile  Phe Val Asn Arg Ser  Ala Val Arg 
    2225                 2230                 2235             


Val Glu  Asp Ala Lys Asp Thr  Ile Lys Leu Leu Glu  Glu Met Glu 
    2240                 2245                 2250             


Cys Lys  Thr Ala Ile Phe Pro  Cys Asp Ile Thr Asn  Glu Asn Gln 
    2255                 2260                 2265             


Val Asp  Thr Phe Val Ala Glu  Ala Ala Lys Gly Met  Pro Pro Ile 
    2270                 2275                 2280             


Lys Gly  Val Ile Gln Gly Ala  Met Val Leu Lys Asp  Ser Ile Phe 
    2285                 2290                 2295             


Glu Lys  Ile Ser Ile Glu Glu  Tyr Ile Thr Met Ile  Arg Pro Lys 
    2300                 2305                 2310             


Val Gln  Gly Ser Phe Asn Leu  His Arg Tyr Met Pro  Arg Asp Met 
    2315                 2320                 2325             


Asp Phe  Phe Ile Leu Glu Ser  Ser Met Thr Gly Val  Val Gly Gln 
    2330                 2335                 2340             


Gly Ser  Gln Ala Ala Tyr Ala  Ala Gly Asn Thr Phe  Leu Asp Gly 
    2345                 2350                 2355             


Phe Ala  Ser Phe Arg Val Ser  Gln Gly Leu Pro Ala  Thr Thr Ile 
    2360                 2365                 2370             


Asp Leu  Gly Ala Ile Ser Gly  Ile Gly Phe Met Ser  Thr Gln Thr 
    2375                 2380                 2385             


Glu Val  Lys Gln Ala Leu Glu  Lys Gln Gly Phe Glu  Tyr Thr Asn 
    2390                 2395                 2400             


Pro Lys  Arg Met Val Ala Leu  Ile Asp Ser Ala Ile  Arg Asn Pro 
    2405                 2410                 2415             


Ala Arg  Pro Ala Gln Gln Ala  His Leu Met Thr Gly  Leu Gly Ser 
    2420                 2425                 2430             


Trp Asn  Glu Glu Ser Ser Leu  Gly Gly Leu Thr Leu  Pro Ile Phe 
    2435                 2440                 2445             


Thr His  Tyr Lys His Leu Thr  Ala Gly Asn Gly Glu  Trp Ala Lys 
    2450                 2455                 2460             


Ser Ala  Thr Gly Asn Asn Val  Arg Thr Ala Leu Arg  Gly Ala Lys 
    2465                 2470                 2475             


Ser Met  Glu Asp Ala Ser Glu  Val Ile Val Gly Ala  Leu Leu Glu 
    2480                 2485                 2490             


Arg Ile  Ala Ser Arg Ser Ala  Ile Gly Pro Glu Asn  Ile Asn Thr 
    2495                 2500                 2505             


Ser Lys  Ser Met Pro Asp Tyr  Gly Ile Asp Ser Leu  Val Ala Val 
    2510                 2515                 2520             


Glu Met  Arg Asn Trp Ile Ser  Lys Asp Met Asp Ser  Thr Leu Pro 
    2525                 2530                 2535             


Ile Met  Asp Leu Leu Gly Ser  Asp Pro Leu Thr His  Leu Ala Thr 
    2540                 2545                 2550             


Lys Ile  Gly Gln Lys Ser Lys  Ser Ile Gln Leu Ala  Glu Gln Thr 
    2555                 2560                 2565             


His Glu  
    2570 


<210>  13
<211>  7783
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  13
atggttgaga atgtctcctc tccttcgtcg ccacggactt cgagtccgag tggctcctgt       60

acgcccacca gcgccaccag cgtgggatcc gacgacaaga gtatgcccat tgctgtcgtc      120

gggatgagct ttcggggccc cagggatgcc atcagcgtgg agagtctctg gaggatgatc      180

tccgagggcc gcgagggatg gagtaaaatc cccaagtcac gatggaataa tgacgccttc      240

taccatccgg atcatagtcg gcatggaacg gtgagggctt ccttttcttt gaaagctgaa      300

cgcgaagcga gatcaaatgg aaagttaaat tcctaataaa aattacgagt ggctaatgga      360

aacgcttaga tcaatgttga aggagggcat ttcttggaag aagatctcgc tcgcttcgat      420

gctccctttt tcaatatgac caacgcagaa gcagccgtga gtattaagag atttctgaca      480

tgcaactatc gtggctgaaa cccgtcaggc actggatccc caacaacgac tgctactcga      540

aagcaccttc gaggctgtcg aaaatggtga gttgttggtc tttgtttccc agaccaaaat      600

gaatccctga cgatcgtagc gggaataccc ctggacaaga tgcttgggtc caagacctcc      660

tgcttcgtgg gctccttctg cggcgactac accgacatgc ttgtgcgaga ccccgaggcc      720

atccccatgt accaatgcac caacgccggt cagtcgcggg ccatcacggc caaccgggtc      780

tcctacttct tcgatctgcg tgggcccagc gtcaccgttg atacggcttg ctccgggagt      840

ctagttgccc tccacctggc ctgtcagagc ttacgaacgg gggatgcgaa aatggccatt      900

gtctccgggg tcaataccat tctgagccat gagtttatga gcactatgag catgatgcgg      960

taagagtcgt acccctatcg ttttgcggat ccagtctctc acaatgtcag gttcctgtcc     1020

cccgatggac gatgttacac gtttgatgag cgggccaatg gctacgcccg aggcgaagga     1080

gtcggctgtc tacttctgaa acccctgtcg gatgccctac gggacaatga tacgatccgc     1140

gccgtcattc gagggacggg ctccaaccag gacggtaaaa cgtcgggcat caccttacca     1200

aacgccaatg cccagcagga attgatccgc gacgtctacg cggctgcggg gctggatcct     1260

ctggaaaccg agtatgtcga gtgccacggt accggcactc aggccggcga tcctctcgag     1320

accggcgccg tggccaaggt cttttctcct ggccggccgg acgatcggcc gctgcgcatc     1380

ggctctatca agacgaatgt cggccacttg gaaggggcga gcggcattgc aggcgtgatc     1440

aaagcggtcc tgacgctgga gaaccaatgt ttcctcccaa atcgaaactt caagagcatt     1500

aacccgcgca ttccgctcaa ggagtggaaa ttgaaggtgc gtgagttgtc gtcgtctgct     1560

accatcgtcg tctgctacca acaagaaact gacatcgtca gatccaactg gagaatgaac     1620

gatgggaaac agtaggcccc catcgggtct ccgtcaacag tttcgggtac gggggaagca     1680

atgcacacgc cgttcttgaa gacaccaagg gttaccttga acagagatcc ctaacaggct     1740

ccttccgccg cgtacgagcg cttccccatg ccgccactga cctcgagcca gtctcggacc     1800

cgggttctgg cccagagcgt acccgacttt ttgtcctgtc cagttttgat caggcgtctg     1860

gtcagcaaca gatcgaccaa ctgcgggaat acttggagca gaactcctct cgaatagatg     1920

atcaatacct ggcagatctc gcttacactc tcggcgagcg ccgctcgccc tttctctgga     1980

agacggcgat gccggcatcg tccgtgtcca gtctcgtcga agggttgaag actcgcgcca     2040

aggtctctcg ggccgagaag aagaagccga cgctgggctt catcttcacg ggtcaaggcg     2100

ctcaatggtg cggcatgggt cgcgagcttc tggcagcgta tcccgtcttt gcttcgagcg     2160

tggacgctat cgccacctat ctgaaaagcc ttggggctcc cttcgacgtc cgggaggagc     2220

tcgtccggga tcccaaggac tccaagatca atcaaccgtt gtacagccag ccgatatgca     2280

ccgccgtcca gattgccctg gtagatctgc tcaccttctg gggaatccgg cctgcctctg     2340

tgaccggcca ctccagcggc gagcttgcgg gggcatacac ggcaggggcc ctgagcatgg     2400

aacacagtat ggccgctgcg tattatcgag gcgttgcgtc cagtgatctt ccccgagacc     2460

acacgcaacg aggcgccatg atggcggtgg gagccagtaa agacgccatc cagccccgat     2520

tgtcctcgct gacgacgggc accgccgtgg tcgcgtgcgt caacagcccc tccagcgtca     2580

ccatctcggg cgatgcatcc gctgtggacg agctgcatgg tttgctcgag aaggaccagg     2640

tgttcgcgcg gaagttggcc gtcgacgtcg cctatcactc gcaccatatg aaagccgtgg     2700

ccgaccaata tcgcaccgcc atggccgccg ccggcgtcac cgcggttcag cctgagtcca     2760

cggagcccga agtggaattc ttctcgtccg tgacgggcga gaaagccagc ctcaccgacc     2820

tgggaatcga atactgggtc gccaacctgc tcagccaggt caagtttgcc gattccgtgc     2880

atcgcctgtg catggagacg tcggcttccg gacgggctcg caagaccaaa accaaggcac     2940

cgaaacgctc aggggccaac aacaaggcca aggtcgacat gctcgtcgag attggcccgc     3000

attcaacgct ggcagggcca attcgccaga tcctcggggc cgaccagacg ctggagcagg     3060

cgtcgatccg ctatgccagt gccctgctgc gcaagtcgag tgcggtcgat accacgctga     3120

ccctggcgtc gaccttactg atggccgggt atccgatcga catggctgcc atcaatcgac     3180

cgtcggatca ccaccgagtg ggcgtcctcg tcgatctccc tccctatccg tggaaccact     3240

cgggatcata ctgggcagag ccgcggttga gcaaagccta tcgcaaccgc gctcatcccc     3300

ggaacgacct tctgggagtg ttggatacgc attccagccc gcgggagccc cggtggcgca     3360

attatctccg gacgagcgag atcccttgga tcaaagacca tatgatccag tcgaacgtgg     3420

tgtatccggc ggccggctac ctcaccatgg cggtcgaagc catcgggcaa cggattgggg     3480

acaacttccc gggccaccgc atctcgggat accgactacg agatgtcgcg atcgaggcgg     3540

ctttggtgat tagcgacgac tcggagccgg aggtcatgct ctccttgcgt ccgtctggcg     3600

acagtggcct ggttccggcc gaacggtggc atgaattcca cgtcctttca gtgacccccg     3660

acaaccggtg gacggagcat tgtcgcgggc tcatctgcgc cgaggtcgcg gccatggacg     3720

gggacgaaga tgaccgtggc gcagaggcag ggttgaccgc cgagacagag cgctggatcg     3780

aggaagcgga gcagctctgc cagaaagacg tcgatatccc ccggttctac gcagagttga     3840

ccggtctggg tctggaatac ggggagacct ttgccaacat gacgcgagca cgttcggcct     3900

cccatgtctg cctcgcggag atcgaagtcg cggacactgc ggctgtcatg cctctgggat     3960

tccagtctcc gttcgtggtc catccctcca ccctggacag tctcttccat cctctcttcg     4020

tcgctctgtc ctccgacgag tcactgcaag atcctgccgt gccggtggcc atcgaggaga     4080

tatggatccg ccacggcatg gccaaggagg ccggacacaa gttccaggtc tgcgcgtcga     4140

cccaggagac gggtcgagac cgcattcagg cagctatctc ggtggttgat gctcagaggg     4200

ctcgcagcgg accggcgttg acggtccgcg gcctgacgtg ccagttcctg gaccgcgcat     4260

cgggagatgt cgagggcgac gagcagccta cacggcttgc atacgagctt cactgggagg     4320

cagatgtaga cctgctgtcg tcgagcgacc tggccacgct gtgtgcggtt ggccgtcccc     4380

gtgatgtagg ggagaaggtc gctcgatatg tgaagcttct cggacacaag aaccctcatc     4440

ttgccatcct ggaggtcgga gccggtcagg gagagctgtg tattccggtg tttcgagccc     4500

tggcagggga ggccaacagc acgccctcgt tccagtcata tacactcgcc gacaccgagc     4560

cgggactgtc ggagaccatt gccacaattg ccgaccagtt tgacgaacgc gccgatctga     4620

ttcaatataa ggagctcgac atctcgtcgg acccgctgca gcagggcttc aacgctcact     4680

ctttggacct catccttctt ccttcccggg gagtgtcggc cacgctccga tcgaagatcc     4740

tcaaacatgc gcaccaattg ctcacgcccg aagggagact gattgtggtc gacacgaggg     4800

acctgcagga atggtggcaa gctcttcgtg agagcaactt tactgatccg gaagtgattc     4860

acgacagtcc gagcgagacg gaggccgaca tctcggtgct ggtgtcgaaa ccacaaccac     4920

aacctcggga tcagacccca tcagaccctc cggatgtcct ggttatcgcc gagaaccaag     4980

actccggcgt gtccattgag catctccagc gtctgctggc ggacgctcat gtgccggcga     5040

ccgtcacgga tttcgctcat gcagacccgg agggcaagac gtgcattgtt ctcagcgagt     5100

tgacgacctc tctgctgagc catcccgacc agcattcgtt tgaaacgctc aaaaggatcc     5160

tcgtcgccgg gggtcgcggc gttctctggg tcgttcgggg agcaaccggc ccagcgccca     5220

ccagcagtct ggccaccggt ctgctgcgca cgattcgctc cgagaccgac gatgatcgac     5280

cgattgtgag cctggatctg gatgcctccc atcccctgtc ggcggaatcc gcagcgcaat     5340

cgatcttctc cgcgttccgc caccgattcg tctcccccgg agggagtcac gaggtcgaat     5400

acgccgaacg cgatgggatc ctgcgcatcc ctcgcgtcgt cgagagttcc ctcgtcaacc     5460

acgagattgt ctcgtccttg cggccggcgg tggccgagga ccagccattc ttccagcccg     5520

gacgtccgct ggaactcacc gtcggcaccc cgggacgtct cgacagtctc tactatgtcg     5580

accgctcctg catctcggag ctacccagtg actacgtcga gatcgaagtc aaagccatcg     5640

ggctcgggaa cggcgatgtc aagaccgctc tgggacatga cgatgccgca acccgtctcg     5700

gagcggaatg cagcggtgtg gtgactgctc tcggggacgc cgtttcgggc ttcaagatcg     5760

gagaccgtgt cgctggcttt ggcgcaggaa ccgtcgccac tttataccga gaccaggcgg     5820

cgcggttcca gctcatcccc gacgacatga gctttgcgcg tgcggccgct ctccccgtgg     5880

catatatcac tgctttcttc gcggtccacg cgctgggcca ggtgagccga ggggaccgag     5940

tcctcatcca ggacgccggc acggccgcgg gccaggctct cctggagctc tgtgccctcg     6000

ccggggggga tatcatcgcc gtggtggatt cgccctcgca aagagccttc ctcgttggcg     6060

agtacgacct cccggcgagc agaatcctgg tcggtctccg cggacgacgt ctagcaacca     6120

gcgtcatgac gctgactagg ggctgcggag tcgatgccat cttcaatttc cgcggaggcg     6180

aggagagacg cctgtgctgg agctgcgtgg caccatatgg ccggttcatt gacctgggcg     6240

gcggaccgtc cgacctgacg gatatgccgc agctcgagat ggccagcttc ttttccaaga     6300

atgcttcctt cacggctctg gacttccact acctggtcac gcaaaagcca caggcggtgc     6360

accggatctg gtccgacgtg atggccctgg tgcgagcaaa ggccatccgg ggcccgccca     6420

ggcttcaact tcattccgtc tccgaggtcg agaccgcgtt gaaacagagt caggacggat     6480

gtgatgtcga gaaagtggtg atccgtgccg aacgggatac aatcgtccag gtctgttgcc     6540

actctgcccc ttatgatatc ctccctcgtg ctaatatgtt ctcttgcagg ccattcctcc     6600

tccgaagggc gacctgctga gggccgacgc gtcatatgtg ctagtcggcg gcctcggagg     6660

cattggacga gcgatggcat cgtggatgat tgccaacgga gcccgacact taatctttgt     6720

caaccgcagt ggcctcgccc gcaacgaagc ccgggagacg gtcgagtctc tcgagggtca     6780

cggtgcccac gtggcggtct attcttgcga tgtcagcgat cgcgaccaag tcgctcagat     6840

ggttgctcag agctccaaag agatgccgcc cattcgaggc gtgattcagg cggccatgat     6900

tctccgggta tgtctgcctt ctcgaaatta gtaggtcgag gactgactgt agtaggatat     6960

gctgtttgag aaaatgagcg tcgacgactt caacaccgtc ctacagccca aatggcaggg     7020

cacatggaat cttcatggcc tcctaccccg agacatggac ttctttatca tgctgtcctc     7080

catcagcggg gtcatcggca acgccactca ggctgcctat gccgctggat cgacgttctt     7140

gggcgcgttc gcccagtatc gcagctccct gggactaccg gccgtgacgc tggatctcgg     7200

cgttatcact ggaatcgggt acctgtccga gcacgaggag ctgctccagg gcatgcagcg     7260

acaaggcttt gaaggcacca acgagcagac gctgatggcc ctcatccgat cagccattgt     7320

cagccctcgt cggacggggt cacaagccga gatcgtcacc gggctgggga cctggcgaga     7380

gggcgtctcg ctgggcaact tcgaccagcc cttgttcgcg cacttccgcc gtcaagccct     7440

gggactccga gatgccacgg cagagggccc gggcaccagc gtccgggaga gtctccgggg     7500

atgcaagacc ctcgacgatg cggtggctct ggtctgtgcg gctctgatcg accgcctggc     7560

ctcgagattg aacaccccgg tggacaatat cgactcccag cgggcgatgt cggagtacgg     7620

ggtggactcg ctggtggcgg tggagatgcg caactggatc ggcaaggaga tggagagcac     7680

gatgcccatt ctggagctgc tggcgaatca atccatctcg cagttgtcgg agaagatagc     7740

tcagcggtca aaggtggtgg cagtgagtgg aagtgaagag tag                       7783


<210>  14
<211>  2451
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  14

Met Val Glu Asn Val Ser Ser Pro Ser Ser Pro Arg Thr Ser Ser Pro 
1               5                   10                  15      


Ser Gly Ser Cys Thr Pro Thr Ser Ala Thr Ser Val Gly Ser Asp Asp 
            20                  25                  30          


Lys Ser Met Pro Ile Ala Val Val Gly Met Ser Phe Arg Gly Pro Arg 
        35                  40                  45              


Asp Ala Ile Ser Val Glu Ser Leu Trp Arg Met Ile Ser Glu Gly Arg 
    50                  55                  60                  


Glu Gly Trp Ser Lys Ile Pro Lys Ser Arg Trp Asn Asn Asp Ala Phe 
65                  70                  75                  80  


Tyr His Pro Asp His Ser Arg His Gly Thr Ile Asn Val Glu Gly Gly 
                85                  90                  95      


His Phe Leu Glu Glu Asp Leu Ala Arg Phe Asp Ala Pro Phe Phe Asn 
            100                 105                 110         


Met Thr Asn Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Leu Leu 
        115                 120                 125             


Leu Glu Ser Thr Phe Glu Ala Val Glu Asn Ala Gly Ile Pro Leu Asp 
    130                 135                 140                 


Lys Met Leu Gly Ser Lys Thr Ser Cys Phe Val Gly Ser Phe Cys Gly 
145                 150                 155                 160 


Asp Tyr Thr Asp Met Leu Val Arg Asp Pro Glu Ala Ile Pro Met Tyr 
                165                 170                 175     


Gln Cys Thr Asn Ala Gly Gln Ser Arg Ala Ile Thr Ala Asn Arg Val 
            180                 185                 190         


Ser Tyr Phe Phe Asp Leu Arg Gly Pro Ser Val Thr Val Asp Thr Ala 
        195                 200                 205             


Cys Ser Gly Ser Leu Val Ala Leu His Leu Ala Cys Gln Ser Leu Arg 
    210                 215                 220                 


Thr Gly Asp Ala Lys Met Ala Ile Val Ser Gly Val Asn Thr Ile Leu 
225                 230                 235                 240 


Ser His Glu Phe Met Ser Thr Met Ser Met Met Arg Phe Leu Ser Pro 
                245                 250                 255     


Asp Gly Arg Cys Tyr Thr Phe Asp Glu Arg Ala Asn Gly Tyr Ala Arg 
            260                 265                 270         


Gly Glu Gly Val Gly Cys Leu Leu Leu Lys Pro Leu Ser Asp Ala Leu 
        275                 280                 285             


Arg Asp Asn Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn 
    290                 295                 300                 


Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu Pro Asn Ala Asn Ala Gln 
305                 310                 315                 320 


Gln Glu Leu Ile Arg Asp Val Tyr Ala Ala Ala Gly Leu Asp Pro Leu 
                325                 330                 335     


Glu Thr Glu Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp 
            340                 345                 350         


Pro Leu Glu Thr Gly Ala Val Ala Lys Val Phe Ser Pro Gly Arg Pro 
        355                 360                 365             


Asp Asp Arg Pro Leu Arg Ile Gly Ser Ile Lys Thr Asn Val Gly His 
    370                 375                 380                 


Leu Glu Gly Ala Ser Gly Ile Ala Gly Val Ile Lys Ala Val Leu Thr 
385                 390                 395                 400 


Leu Glu Asn Gln Cys Phe Leu Pro Asn Arg Asn Phe Lys Ser Ile Asn 
                405                 410                 415     


Pro Arg Ile Pro Leu Lys Glu Trp Lys Leu Lys Ile Gln Leu Glu Asn 
            420                 425                 430         


Glu Arg Trp Glu Thr Val Gly Pro His Arg Val Ser Val Asn Ser Phe 
        435                 440                 445             


Gly Tyr Gly Gly Ser Asn Ala His Ala Val Leu Glu Asp Thr Lys Gly 
    450                 455                 460                 


Tyr Leu Glu Gln Arg Ser Leu Thr Gly Ser Phe Arg Arg Val Arg Ala 
465                 470                 475                 480 


Leu Pro His Ala Ala Thr Asp Leu Glu Pro Val Ser Asp Pro Gly Ser 
                485                 490                 495     


Gly Pro Glu Arg Thr Arg Leu Phe Val Leu Ser Ser Phe Asp Gln Ala 
            500                 505                 510         


Ser Gly Gln Gln Gln Ile Asp Gln Leu Arg Glu Tyr Leu Glu Gln Asn 
        515                 520                 525             


Ser Ser Arg Ile Asp Asp Gln Tyr Leu Ala Asp Leu Ala Tyr Thr Leu 
    530                 535                 540                 


Gly Glu Arg Arg Ser Pro Phe Leu Trp Lys Thr Ala Met Pro Ala Ser 
545                 550                 555                 560 


Ser Val Ser Ser Leu Val Glu Gly Leu Lys Thr Arg Ala Lys Val Ser 
                565                 570                 575     


Arg Ala Glu Lys Lys Lys Pro Thr Leu Gly Phe Ile Phe Thr Gly Gln 
            580                 585                 590         


Gly Ala Gln Trp Cys Gly Met Gly Arg Glu Leu Leu Ala Ala Tyr Pro 
        595                 600                 605             


Val Phe Ala Ser Ser Val Asp Ala Ile Ala Thr Tyr Leu Lys Ser Leu 
    610                 615                 620                 


Gly Ala Pro Phe Asp Val Arg Glu Glu Leu Val Arg Asp Pro Lys Asp 
625                 630                 635                 640 


Ser Lys Ile Asn Gln Pro Leu Tyr Ser Gln Pro Ile Cys Thr Ala Val 
                645                 650                 655     


Gln Ile Ala Leu Val Asp Leu Leu Thr Phe Trp Gly Ile Arg Pro Ala 
            660                 665                 670         


Ser Val Thr Gly His Ser Ser Gly Glu Leu Ala Gly Ala Tyr Thr Ala 
        675                 680                 685             


Gly Ala Leu Ser Met Glu His Ser Met Ala Ala Ala Tyr Tyr Arg Gly 
    690                 695                 700                 


Val Ala Ser Ser Asp Leu Pro Arg Asp His Thr Gln Arg Gly Ala Met 
705                 710                 715                 720 


Met Ala Val Gly Ala Ser Lys Asp Ala Ile Gln Pro Arg Leu Ser Ser 
                725                 730                 735     


Leu Thr Thr Gly Thr Ala Val Val Ala Cys Val Asn Ser Pro Ser Ser 
            740                 745                 750         


Val Thr Ile Ser Gly Asp Ala Ser Ala Val Asp Glu Leu His Gly Leu 
        755                 760                 765             


Leu Glu Lys Asp Gln Val Phe Ala Arg Lys Leu Ala Val Asp Val Ala 
    770                 775                 780                 


Tyr His Ser His His Met Lys Ala Val Ala Asp Gln Tyr Arg Thr Ala 
785                 790                 795                 800 


Met Ala Ala Ala Gly Val Thr Ala Val Gln Pro Glu Ser Thr Glu Pro 
                805                 810                 815     


Glu Val Glu Phe Phe Ser Ser Val Thr Gly Glu Lys Ala Ser Leu Thr 
            820                 825                 830         


Asp Leu Gly Ile Glu Tyr Trp Val Ala Asn Leu Leu Ser Gln Val Lys 
        835                 840                 845             


Phe Ala Asp Ser Val His Arg Leu Cys Met Glu Thr Ser Ala Ser Gly 
    850                 855                 860                 


Arg Ala Arg Lys Thr Lys Thr Lys Ala Pro Lys Arg Ser Gly Ala Asn 
865                 870                 875                 880 


Asn Lys Ala Lys Val Asp Met Leu Val Glu Ile Gly Pro His Ser Thr 
                885                 890                 895     


Leu Ala Gly Pro Ile Arg Gln Ile Leu Gly Ala Asp Gln Thr Leu Glu 
            900                 905                 910         


Gln Ala Ser Ile Arg Tyr Ala Ser Ala Leu Leu Arg Lys Ser Ser Ala 
        915                 920                 925             


Val Asp Thr Thr Leu Thr Leu Ala Ser Thr Leu Leu Met Ala Gly Tyr 
    930                 935                 940                 


Pro Ile Asp Met Ala Ala Ile Asn Arg Pro Ser Asp His His Arg Val 
945                 950                 955                 960 


Gly Val Leu Val Asp Leu Pro Pro Tyr Pro Trp Asn His Ser Gly Ser 
                965                 970                 975     


Tyr Trp Ala Glu Pro Arg Leu Ser Lys Ala Tyr Arg Asn Arg Ala His 
            980                 985                 990         


Pro Arg Asn Asp Leu Leu Gly Val  Leu Asp Thr His Ser  Ser Pro Arg 
        995                 1000                 1005             


Glu Pro  Arg Trp Arg Asn Tyr  Leu Arg Thr Ser Glu  Ile Pro Trp 
    1010                 1015                 1020             


Ile Lys  Asp His Met Ile Gln  Ser Asn Val Val Tyr  Pro Ala Ala 
    1025                 1030                 1035             


Gly Tyr  Leu Thr Met Ala Val  Glu Ala Ile Gly Gln  Arg Ile Gly 
    1040                 1045                 1050             


Asp Asn  Phe Pro Gly His Arg  Ile Ser Gly Tyr Arg  Leu Arg Asp 
    1055                 1060                 1065             


Val Ala  Ile Glu Ala Ala Leu  Val Ile Ser Asp Asp  Ser Glu Pro 
    1070                 1075                 1080             


Glu Val  Met Leu Ser Leu Arg  Pro Ser Gly Asp Ser  Gly Leu Val 
    1085                 1090                 1095             


Pro Ala  Glu Arg Trp His Glu  Phe His Val Leu Ser  Val Thr Pro 
    1100                 1105                 1110             


Asp Asn  Arg Trp Thr Glu His  Cys Arg Gly Leu Ile  Cys Ala Glu 
    1115                 1120                 1125             


Val Ala  Ala Met Asp Gly Asp  Glu Asp Asp Arg Gly  Ala Glu Ala 
    1130                 1135                 1140             


Gly Leu  Thr Ala Glu Thr Glu  Arg Trp Ile Glu Glu  Ala Glu Gln 
    1145                 1150                 1155             


Leu Cys  Gln Lys Asp Val Asp  Ile Pro Arg Phe Tyr  Ala Glu Leu 
    1160                 1165                 1170             


Thr Gly  Leu Gly Leu Glu Tyr  Gly Glu Thr Phe Ala  Asn Met Thr 
    1175                 1180                 1185             


Arg Ala  Arg Ser Ala Ser His  Val Cys Leu Ala Glu  Ile Glu Val 
    1190                 1195                 1200             


Ala Asp  Thr Ala Ala Val Met  Pro Leu Gly Phe Gln  Ser Pro Phe 
    1205                 1210                 1215             


Val Val  His Pro Ser Thr Leu  Asp Ser Leu Phe His  Pro Leu Phe 
    1220                 1225                 1230             


Val Ala  Leu Ser Ser Asp Glu  Ser Leu Gln Asp Pro  Ala Val Pro 
    1235                 1240                 1245             


Val Ala  Ile Glu Glu Ile Trp  Ile Arg His Gly Met  Ala Lys Glu 
    1250                 1255                 1260             


Ala Gly  His Lys Phe Gln Val  Cys Ala Ser Thr Gln  Glu Thr Gly 
    1265                 1270                 1275             


Arg Asp  Arg Ile Gln Ala Ala  Ile Ser Val Val Asp  Ala Gln Arg 
    1280                 1285                 1290             


Ala Arg  Ser Gly Pro Ala Leu  Thr Val Arg Gly Leu  Thr Cys Gln 
    1295                 1300                 1305             


Phe Leu  Asp Arg Ala Ser Gly  Asp Val Glu Gly Asp  Glu Gln Pro 
    1310                 1315                 1320             


Thr Arg  Leu Ala Tyr Glu Leu  His Trp Glu Ala Asp  Val Asp Leu 
    1325                 1330                 1335             


Leu Ser  Ser Ser Asp Leu Ala  Thr Leu Cys Ala Val  Gly Arg Pro 
    1340                 1345                 1350             


Arg Asp  Val Gly Glu Lys Val  Ala Arg Tyr Val Lys  Leu Leu Gly 
    1355                 1360                 1365             


His Lys  Asn Pro His Leu Ala  Ile Leu Glu Val Gly  Ala Gly Gln 
    1370                 1375                 1380             


Gly Glu  Leu Cys Ile Pro Val  Phe Arg Ala Leu Ala  Gly Glu Ala 
    1385                 1390                 1395             


Asn Ser  Thr Pro Ser Phe Gln  Ser Tyr Thr Leu Ala  Asp Thr Glu 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Thr Ile  Ala Thr Ile Ala Asp  Gln Phe Asp 
    1415                 1420                 1425             


Glu Arg  Ala Asp Leu Ile Gln  Tyr Lys Glu Leu Asp  Ile Ser Ser 
    1430                 1435                 1440             


Asp Pro  Leu Gln Gln Gly Phe  Asn Ala His Ser Leu  Asp Leu Ile 
    1445                 1450                 1455             


Leu Leu  Pro Ser Arg Gly Val  Ser Ala Thr Leu Arg  Ser Lys Ile 
    1460                 1465                 1470             


Leu Lys  His Ala His Gln Leu  Leu Thr Pro Glu Gly  Arg Leu Ile 
    1475                 1480                 1485             


Val Val  Asp Thr Arg Asp Leu  Gln Glu Trp Trp Gln  Ala Leu Arg 
    1490                 1495                 1500             


Glu Ser  Asn Phe Thr Asp Pro  Glu Val Ile His Asp  Ser Pro Ser 
    1505                 1510                 1515             


Glu Thr  Glu Ala Asp Ile Ser  Val Leu Val Ser Lys  Pro Gln Pro 
    1520                 1525                 1530             


Gln Pro  Arg Asp Gln Thr Pro  Ser Asp Pro Pro Asp  Val Leu Val 
    1535                 1540                 1545             


Ile Ala  Glu Asn Gln Asp Ser  Gly Val Ser Ile Glu  His Leu Gln 
    1550                 1555                 1560             


Arg Leu  Leu Ala Asp Ala His  Val Pro Ala Thr Val  Thr Asp Phe 
    1565                 1570                 1575             


Ala His  Ala Asp Pro Glu Gly  Lys Thr Cys Ile Val  Leu Ser Glu 
    1580                 1585                 1590             


Leu Thr  Thr Ser Leu Leu Ser  His Pro Asp Gln His  Ser Phe Glu 
    1595                 1600                 1605             


Thr Leu  Lys Arg Ile Leu Val  Ala Gly Gly Arg Gly  Val Leu Trp 
    1610                 1615                 1620             


Val Val  Arg Gly Ala Thr Gly  Pro Ala Pro Thr Ser  Ser Leu Ala 
    1625                 1630                 1635             


Thr Gly  Leu Leu Arg Thr Ile  Arg Ser Glu Thr Asp  Asp Asp Arg 
    1640                 1645                 1650             


Pro Ile  Val Ser Leu Asp Leu  Asp Ala Ser His Pro  Leu Ser Ala 
    1655                 1660                 1665             


Glu Ser  Ala Ala Gln Ser Ile  Phe Ser Ala Phe Arg  His Arg Phe 
    1670                 1675                 1680             


Val Ser  Pro Gly Gly Ser His  Glu Val Glu Tyr Ala  Glu Arg Asp 
    1685                 1690                 1695             


Gly Ile  Leu Arg Ile Pro Arg  Val Val Glu Ser Ser  Leu Val Asn 
    1700                 1705                 1710             


His Glu  Ile Val Ser Ser Leu  Arg Pro Ala Val Ala  Glu Asp Gln 
    1715                 1720                 1725             


Pro Phe  Phe Gln Pro Gly Arg  Pro Leu Glu Leu Thr  Val Gly Thr 
    1730                 1735                 1740             


Pro Gly  Arg Leu Asp Ser Leu  Tyr Tyr Val Asp Arg  Ser Cys Ile 
    1745                 1750                 1755             


Ser Glu  Leu Pro Ser Asp Tyr  Val Glu Ile Glu Val  Lys Ala Ile 
    1760                 1765                 1770             


Gly Leu  Gly Asn Gly Asp Val  Lys Thr Ala Leu Gly  His Asp Asp 
    1775                 1780                 1785             


Ala Ala  Thr Arg Leu Gly Ala  Glu Cys Ser Gly Val  Val Thr Ala 
    1790                 1795                 1800             


Leu Gly  Asp Ala Val Ser Gly  Phe Lys Ile Gly Asp  Arg Val Ala 
    1805                 1810                 1815             


Gly Phe  Gly Ala Gly Thr Val  Ala Thr Leu Tyr Arg  Asp Gln Ala 
    1820                 1825                 1830             


Ala Arg  Phe Gln Leu Ile Pro  Asp Asp Met Ser Phe  Ala Arg Ala 
    1835                 1840                 1845             


Ala Ala  Leu Pro Val Ala Tyr  Ile Thr Ala Phe Phe  Ala Val His 
    1850                 1855                 1860             


Ala Leu  Gly Gln Val Ser Arg  Gly Asp Arg Val Leu  Ile Gln Asp 
    1865                 1870                 1875             


Ala Gly  Thr Ala Ala Gly Gln  Ala Leu Leu Glu Leu  Cys Ala Leu 
    1880                 1885                 1890             


Ala Gly  Gly Asp Ile Ile Ala  Val Val Asp Ser Pro  Ser Gln Arg 
    1895                 1900                 1905             


Ala Phe  Leu Val Gly Glu Tyr  Asp Leu Pro Ala Ser  Arg Ile Leu 
    1910                 1915                 1920             


Val Gly  Leu Arg Gly Arg Arg  Leu Ala Thr Ser Val  Met Thr Leu 
    1925                 1930                 1935             


Thr Arg  Gly Cys Gly Val Asp  Ala Ile Phe Asn Phe  Arg Gly Gly 
    1940                 1945                 1950             


Glu Glu  Arg Arg Leu Cys Trp  Ser Cys Val Ala Pro  Tyr Gly Arg 
    1955                 1960                 1965             


Phe Ile  Asp Leu Gly Gly Gly  Pro Ser Asp Leu Thr  Asp Met Pro 
    1970                 1975                 1980             


Gln Leu  Glu Met Ala Ser Phe  Phe Ser Lys Asn Ala  Ser Phe Thr 
    1985                 1990                 1995             


Ala Leu  Asp Phe His Tyr Leu  Val Thr Gln Lys Pro  Gln Ala Val 
    2000                 2005                 2010             


His Arg  Ile Trp Ser Asp Val  Met Ala Leu Val Arg  Ala Lys Ala 
    2015                 2020                 2025             


Ile Arg  Gly Pro Pro Arg Leu  Gln Leu His Ser Val  Ser Glu Val 
    2030                 2035                 2040             


Glu Thr  Ala Leu Lys Gln Ser  Gln Asp Gly Cys Asp  Val Glu Lys 
    2045                 2050                 2055             


Val Val  Ile Arg Ala Glu Arg  Asp Thr Ile Val Gln  Ala Ile Pro 
    2060                 2065                 2070             


Pro Pro  Lys Gly Asp Leu Leu  Arg Ala Asp Ala Ser  Tyr Val Leu 
    2075                 2080                 2085             


Val Gly  Gly Leu Gly Gly Ile  Gly Arg Ala Met Ala  Ser Trp Met 
    2090                 2095                 2100             


Ile Ala  Asn Gly Ala Arg His  Leu Ile Phe Val Asn  Arg Ser Gly 
    2105                 2110                 2115             


Leu Ala  Arg Asn Glu Ala Arg  Glu Thr Val Glu Ser  Leu Glu Gly 
    2120                 2125                 2130             


His Gly  Ala His Val Ala Val  Tyr Ser Cys Asp Val  Ser Asp Arg 
    2135                 2140                 2145             


Asp Gln  Val Ala Gln Met Val  Ala Gln Ser Ser Lys  Glu Met Pro 
    2150                 2155                 2160             


Pro Ile  Arg Gly Val Ile Gln  Ala Ala Met Ile Leu  Arg Asp Met 
    2165                 2170                 2175             


Leu Phe  Glu Lys Met Ser Val  Asp Asp Phe Asn Thr  Val Leu Gln 
    2180                 2185                 2190             


Pro Lys  Trp Gln Gly Thr Trp  Asn Leu His Gly Leu  Leu Pro Arg 
    2195                 2200                 2205             


Asp Met  Asp Phe Phe Ile Met  Leu Ser Ser Ile Ser  Gly Val Ile 
    2210                 2215                 2220             


Gly Asn  Ala Thr Gln Ala Ala  Tyr Ala Ala Gly Ser  Thr Phe Leu 
    2225                 2230                 2235             


Gly Ala  Phe Ala Gln Tyr Arg  Ser Ser Leu Gly Leu  Pro Ala Val 
    2240                 2245                 2250             


Thr Leu  Asp Leu Gly Val Ile  Thr Gly Ile Gly Tyr  Leu Ser Glu 
    2255                 2260                 2265             


His Glu  Glu Leu Leu Gln Gly  Met Gln Arg Gln Gly  Phe Glu Gly 
    2270                 2275                 2280             


Thr Asn  Glu Gln Thr Leu Met  Ala Leu Ile Arg Ser  Ala Ile Val 
    2285                 2290                 2295             


Ser Pro  Arg Arg Thr Gly Ser  Gln Ala Glu Ile Val  Thr Gly Leu 
    2300                 2305                 2310             


Gly Thr  Trp Arg Glu Gly Val  Ser Leu Gly Asn Phe  Asp Gln Pro 
    2315                 2320                 2325             


Leu Phe  Ala His Phe Arg Arg  Gln Ala Leu Gly Leu  Arg Asp Ala 
    2330                 2335                 2340             


Thr Ala  Glu Gly Pro Gly Thr  Ser Val Arg Glu Ser  Leu Arg Gly 
    2345                 2350                 2355             


Cys Lys  Thr Leu Asp Asp Ala  Val Ala Leu Val Cys  Ala Ala Leu 
    2360                 2365                 2370             


Ile Asp  Arg Leu Ala Ser Arg  Leu Asn Thr Pro Val  Asp Asn Ile 
    2375                 2380                 2385             


Asp Ser  Gln Arg Ala Met Ser  Glu Tyr Gly Val Asp  Ser Leu Val 
    2390                 2395                 2400             


Ala Val  Glu Met Arg Asn Trp  Ile Gly Lys Glu Met  Glu Ser Thr 
    2405                 2410                 2415             


Met Pro  Ile Leu Glu Leu Leu  Ala Asn Gln Ser Ile  Ser Gln Leu 
    2420                 2425                 2430             


Ser Glu  Lys Ile Ala Gln Arg  Ser Lys Val Val Ala  Val Ser Gly 
    2435                 2440                 2445             


Ser Glu  Glu 
    2450     


<210>  15
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 14

<400>  15

Met Val Glu Asn Val Ser Ser Pro Ser Ser Pro Arg Thr Ser Ser Pro 
1               5                   10                  15      


Ser Gly Ser Cys Thr Pro Thr Ser Ala Thr Ser Val Gly Ser Asp Asp 
            20                  25                  30          


Lys Ser Met Pro Ile Ala Val Val Gly Met Ser Phe Arg Gly Pro Arg 
        35                  40                  45              


Asp Ala Ile Ser Val Glu Ser Leu Trp Arg Met Ile Ser Glu Gly Arg 
    50                  55                  60                  


Glu Gly Trp Ser Lys Ile Pro Asp Ser Arg Trp Asn Asn Asp Ala Phe 
65                  70                  75                  80  


Tyr His Pro Asp His Ser Arg His Gly Thr Ile Gln Val Glu Gly Gly 
                85                  90                  95      


His Phe Leu Glu Glu Asp Leu Ala Arg Phe Asp Ala Pro Phe Phe Asn 
            100                 105                 110         


Met Thr Asn Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Leu Leu 
        115                 120                 125             


Leu Glu Ser Thr Phe Glu Ala Val Glu Asn Ala Gly Ile Pro Leu Asp 
    130                 135                 140                 


Lys Met Thr Gly Ser Lys Thr Ser Cys Phe Val Gly Ser Phe Cys Gly 
145                 150                 155                 160 


Asp Tyr Thr Asp Met Leu Val Arg Asp Val Glu Ala Ile Pro Met Tyr 
                165                 170                 175     


Gln Cys Thr Asn Ala Gly Gln Ser Arg Ala Ile Thr Ala Asn Arg Val 
            180                 185                 190         


Ser Tyr Phe Phe Asp Leu Arg Gly Pro Ser Val Thr Val Asp Thr Ala 
        195                 200                 205             


Cys Ser Gly Ser Leu Val Ala Leu His Leu Ala Cys Gln Ser Leu Arg 
    210                 215                 220                 


Thr Gly Asp Ala Lys Met Ala Ile Val Ser Gly Val Asn Thr Ile Leu 
225                 230                 235                 240 


Ser His Glu Phe Met Ser Thr Met Ser Met Met Arg Phe Leu Ser Pro 
                245                 250                 255     


Asp Gly Arg Cys Tyr Thr Phe Asp Glu Arg Ala Asn Gly Tyr Ala Arg 
            260                 265                 270         


Gly Glu Gly Val Gly Cys Leu Leu Leu Lys Pro Leu Ser Asp Ala Leu 
        275                 280                 285             


Arg Asp Asn Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn 
    290                 295                 300                 


Gln Asp Gly Lys Thr Asp Gly Ile Thr Leu Pro Asn Ala Asn Ala Gln 
305                 310                 315                 320 


Gln Glu Leu Ile Arg Asp Val Tyr Ala Ala Ala Gly Leu Asp Pro Leu 
                325                 330                 335     


Glu Thr Glu Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp 
            340                 345                 350         


Pro Leu Glu Thr Gly Ala Val Ala Lys Val Phe Ser Pro Gly Arg Pro 
        355                 360                 365             


Asp Asp Arg Pro Leu Arg Ile Gly Ser Ile Lys Thr Asn Val Gly His 
    370                 375                 380                 


Leu Glu Gly Ala Ser Gly Ile Ala Gly Val Ile Lys Ala Val Leu Thr 
385                 390                 395                 400 


Leu Glu Asn Gln Cys Phe Leu Pro Asn Arg Asn Phe Lys Ser Ile Asn 
                405                 410                 415     


Pro Arg Ile Pro Leu Lys Glu Trp Lys Leu Lys Ile Gln Leu Glu Asn 
            420                 425                 430         


Glu Arg Trp Glu Thr Val Gly Pro His Arg Val Ser Val Asn Ser Phe 
        435                 440                 445             


Gly Tyr Gly Gly Ser Asn Ala His Ala Val Leu Glu Asp Thr Lys Gly 
    450                 455                 460                 


Glu Leu Met Gln Arg Glu Val Thr Gly Ser Phe Arg Arg Val Arg Ala 
465                 470                 475                 480 


Leu Pro Arg Ala Ala Thr Asp Leu Glu Pro Val Ser Arg Pro Gly Ala 
                485                 490                 495     


Phe Pro Asp Gly Thr Arg Leu Phe Val Leu Ser Ser Phe Asp Gln Ala 
            500                 505                 510         


Ser Gly Gln Gln Gln Ile Asp Gln Leu Arg Glu Tyr Leu Glu Gln Asn 
        515                 520                 525             


Ser Gly Arg Ile Asp Asp Gln Tyr Leu Ala Asp Leu Ala Tyr Thr Leu 
    530                 535                 540                 


Gly Glu Arg Arg Ser Pro Phe Leu Trp Lys Thr Ala Met Pro Ala Ser 
545                 550                 555                 560 


Ser Gln Ser Ser Leu Val Glu Gly Leu Lys Thr Arg Ala Lys Val Ser 
                565                 570                 575     


Arg Ala Lys Lys Lys Lys Pro Thr Leu Gly Phe Ile Phe Thr Gly Gln 
            580                 585                 590         


Gly Ala Gln Trp Cys Gly Met Gly Arg Glu Leu Leu Ala Ala Tyr Pro 
        595                 600                 605             


Val Phe Ala Ser Ser Val Asp Ala Ile Ala Thr Tyr Leu Lys Ser Leu 
    610                 615                 620                 


Gly Pro Pro Phe Asp Val Arg Glu Glu Leu Val Arg Asp Pro Lys Asp 
625                 630                 635                 640 


Ser Lys Ile Asn Gln Pro Leu Tyr Ser Gln Pro Ile Cys Thr Ala Val 
                645                 650                 655     


Gln Ile Ala Leu Val Asp Leu Leu Thr Phe Trp Gly Ile Arg Pro Ala 
            660                 665                 670         


Ser Val Thr Gly His Ser Ser Gly Glu Leu Ala Gly Ala Tyr Thr Ala 
        675                 680                 685             


Gly Ala Leu Ser Met Glu His Ser Met Ala Ala Ala Tyr Tyr Arg Gly 
    690                 695                 700                 


Val Ala Ser Ser Asp Leu Pro Arg Asp Leu Thr Gln Ala Gly Ala Met 
705                 710                 715                 720 


Met Ala Val Gly Ala Ser Lys Asp Ala Ile Gln Pro Arg Leu Ser Ser 
                725                 730                 735     


Leu Thr Ser Gly Thr Ala Val Val Ala Cys Val Asn Ser Pro Ala Ser 
            740                 745                 750         


Val Thr Ile Ser Gly Asp Ala Ser Ala Val Asp Glu Leu His Gly Leu 
        755                 760                 765             


Leu Glu Lys Asp Gln Val Phe Ala Arg Lys Leu Ala Val Asp Val Ala 
    770                 775                 780                 


Tyr His Ser His His Met Lys Ala Val Ala Asp Gln Tyr Arg Thr Ala 
785                 790                 795                 800 


Met Ala Ala Ala Gly Val Thr Ala Val Ser Pro Glu Ser Arg Glu Pro 
                805                 810                 815     


Glu Val Glu Phe Phe Ser Ser Val Thr Gly Glu Lys Ala Ser Leu Thr 
            820                 825                 830         


Asp Leu Gly Ile Glu Tyr Trp Val Ala Asn Leu Leu Ser Gln Val Lys 
        835                 840                 845             


Phe Ala Asp Ser Val His Arg Leu Cys Met Thr Thr Ser Ala Ser Gly 
    850                 855                 860                 


Arg Ala Arg Lys Thr Lys Thr Lys Ala Pro Lys Arg Ser Gly Ala Thr 
865                 870                 875                 880 


Asn Lys Ala Lys Val Asp Met Leu Val Glu Ile Gly Pro His Ser Thr 
                885                 890                 895     


Leu Ala Gly Pro Ile Arg Gln Ile Leu Gly Ser Asp Gln Thr Leu Glu 
            900                 905                 910         


Gln Ala Lys Ile Arg Tyr Ala Ser Ala Leu Leu Arg Lys Ser Ser Ala 
        915                 920                 925             


Val Asp Thr Thr Leu Thr Leu Ala Ser Thr Leu Leu Met Ala Gly Tyr 
    930                 935                 940                 


Pro Ile Asp Met Ala Ala Ile Asn Arg Pro Ser Asp His His Gly Val 
945                 950                 955                 960 


Gly Val Leu Val Asp Leu Pro Pro Tyr Pro Trp Asn His Ser Gly Ser 
                965                 970                 975     


Tyr Trp Leu Glu Pro Arg Leu Ser Lys Ala Tyr Arg Asn Arg Lys His 
            980                 985                 990         


Pro Arg Asn Asp Leu Leu Gly Val  Ala Asp Thr His Ser  Ser Phe Arg 
        995                 1000                 1005             


Glu Pro  Arg Trp Arg Asn Tyr  Leu Arg Thr Ser Glu  Ile Pro Trp 
    1010                 1015                 1020             


Ile Lys  Asp His Met Ile Gln  Ser Asn Val Val Tyr  Pro Ala Ala 
    1025                 1030                 1035             


Gly Tyr  Leu Thr Met Ala Val  Glu Ala Ile Gly Gln  Arg Ile Gly 
    1040                 1045                 1050             


Asp Asn  Phe Arg Gly His Arg  Ile Ser Gly Tyr Arg  Leu Arg Asp 
    1055                 1060                 1065             


Val Glu  Ile Glu Ala Ala Leu  Val Ile Ser Asp Gly  Ser Glu Pro 
    1070                 1075                 1080             


Glu Val  Met Leu Ser Leu Arg  Pro Ala Gly Asp Ser  Gly Leu Val 
    1085                 1090                 1095             


Gly Ala  Glu Arg Trp His Glu  Phe His Val Ser Ser  Val Thr Pro 
    1100                 1105                 1110             


Asp Asn  Arg Trp Thr Glu His  Cys Arg Gly Leu Ile  Cys Ala Glu 
    1115                 1120                 1125             


Gln Ala  Ala Met Asp Ser Asp  Glu Asp Asp Arg Gly  Ala Glu Ala 
    1130                 1135                 1140             


Gly Leu  Thr Ala Glu Thr Glu  Arg Trp Ile Glu Glu  Ala Asn Gln 
    1145                 1150                 1155             


Leu Cys  Gln Lys Asp Val Asp  Ile Pro Arg Phe Tyr  Ala Ser Leu 
    1160                 1165                 1170             


Thr Gly  Leu Gly Leu Glu Tyr  Gly Glu Thr Phe Ala  Asn Met Thr 
    1175                 1180                 1185             


Arg Ala  Arg Ser Ala Ser His  Ala Cys Leu Ala Glu  Ile Glu Val 
    1190                 1195                 1200             


Ala Asp  Thr Ser Ala Val Met  Pro Leu Gly Phe Gln  Ser Pro Phe 
    1205                 1210                 1215             


Val Val  His Pro Ser Thr Leu  Asp Ser Leu Phe His  Pro Leu Phe 
    1220                 1225                 1230             


Val Ala  Leu Ser Ser Asp Glu  Ser Gly Gln Thr Pro  Ala Val Pro 
    1235                 1240                 1245             


Val Ala  Ile Glu Glu Ile Trp  Ile His His Gly Gly  Ala Lys Glu 
    1250                 1255                 1260             


Ala Gly  His Ala Phe Glu Val  Cys Ala Ser Thr Gln  Glu Thr Gly 
    1265                 1270                 1275             


Arg Asp  Arg Ile Gln Ala Ala  Ile Ser Val Val Asp  Ala Gln Arg 
    1280                 1285                 1290             


Asn Arg  Ser Gly Pro Ala Leu  Thr Val Arg Gly Leu  Thr Cys Gln 
    1295                 1300                 1305             


Phe Leu  Asp Arg Ala Ser Gly  Asp Val Glu Gly Asp  Glu Ser Pro 
    1310                 1315                 1320             


Thr Arg  Trp Ala Tyr Glu Leu  His Trp Glu Ala Asp  Ile Asp Leu 
    1325                 1330                 1335             


Leu Ser  Ser Ser Asp Leu Ala  Arg Leu Cys Ala Val  Gly Arg Pro 
    1340                 1345                 1350             


Arg Asp  Val Tyr Glu Lys Val  Ala Glu Tyr Val Lys  Leu Leu Gly 
    1355                 1360                 1365             


His Lys  Asn Pro Leu Leu Ala  Ile Leu Glu Val Gly  Ala Gly Gln 
    1370                 1375                 1380             


Gly Glu  Leu Cys Asn Arg Val  Phe Arg Ala Leu Ala  Gly Glu Ala 
    1385                 1390                 1395             


Gly Ser  Thr Pro Ser Phe Gln  Asn Tyr Thr Leu Ala  Asp Thr Glu 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Asn Ile  Ala Thr Ile Ala Asp  Gln Phe Asp 
    1415                 1420                 1425             


Gly Arg  Ala Asp Leu Ile Gln  Tyr Lys Glu Leu Asp  Ile Ser Lys 
    1430                 1435                 1440             


Asp Pro  Leu Gln Gln Gly Phe  Asn Ala His Ser Leu  Asp Leu Ile 
    1445                 1450                 1455             


Leu Leu  Pro Ser Arg Gly Val  Ser Ala Thr Lys Arg  Glu Lys Ile 
    1460                 1465                 1470             


Leu Lys  His Ala His Gln Leu  Leu Thr Pro Glu Gly  Arg Leu Ile 
    1475                 1480                 1485             


Val Val  Asp Thr Arg Asp Leu  Gln Gly Trp Trp Glu  Ala Leu Arg 
    1490                 1495                 1500             


Glu Ser  Asn Phe Thr Asp Pro  Glu Val Ile Phe Asp  Ser Pro Asp 
    1505                 1510                 1515             


Glu Thr  Leu Ala Asp His Ser  Val Leu Val Ser Lys  Pro Gln Pro 
    1520                 1525                 1530             


Gln Pro  Arg Asp Leu Thr Pro  Ser Asp Pro Pro Asp  Val Leu Val 
    1535                 1540                 1545             


Ile Ala  Glu Asn Gly Asp Pro  Gly Glu Arg Ile Glu  His Leu Lys 
    1550                 1555                 1560             


Arg Ser  Leu Ala Asp Ala His  Val Lys Ala Thr Val  Thr Asp Phe 
    1565                 1570                 1575             


Ala His  Ala Asp Pro Glu Gly  Lys Ile Cys Ile Val  Leu Ser Glu 
    1580                 1585                 1590             


Leu Thr  Thr Ser Leu Leu Ser  His Pro Asp Gln His  Ser Phe Glu 
    1595                 1600                 1605             


Thr Leu  Lys Arg Ile Leu Val  Ala Gly Gly Ser Arg  Val Leu Trp 
    1610                 1615                 1620             


Val Val  Arg Gly Ala Thr Cys  Pro Ala Pro Thr Ser  Ser Leu Ala 
    1625                 1630                 1635             


Thr Gly  Leu Leu Arg Thr Ile  Arg Thr Glu Thr Asp  Asp Asp Arg 
    1640                 1645                 1650             


Pro Ile  Val Ser Leu Asp Leu  Asp Glu Ser His Asp  Leu Ser Ala 
    1655                 1660                 1665             


Glu Ser  Ala Ala Gln Ser Ile  Phe Ser Ala Phe Arg  Gln Arg Phe 
    1670                 1675                 1680             


Val Ser  Pro Gly Ala Ser His  Glu Val Glu Tyr Ala  Glu Arg Asp 
    1685                 1690                 1695             


Gly Ile  Leu Arg Ile Pro Arg  Val Val Glu Ser Ser  Glu Val Asn 
    1700                 1705                 1710             


Glu Gly  Ile Val Ser Ser Leu  Arg Pro Ala Val Ala  Glu Asp Gln 
    1715                 1720                 1725             


Pro Phe  Phe Gln Pro Gly Thr  Pro Leu Glu Leu Ala  Val Gly Ala 
    1730                 1735                 1740             


Pro Gly  Leu Leu Asp Ser Leu  Tyr Tyr Val Asp Arg  Ser Cys Ile 
    1745                 1750                 1755             


Ser Glu  Leu Pro Ser Asp Tyr  Val Glu Ile Glu Val  Lys Ala Ile 
    1760                 1765                 1770             


Gly Leu  Gly Asn Gly Asp Val  Lys Thr Ala Leu Gly  Lys Asp Asp 
    1775                 1780                 1785             


Ala Ala  Thr Arg Leu Gly Ala  Glu Cys Ser Gly Val  Val Thr Ala 
    1790                 1795                 1800             


Leu Gly  Asp Ala Val Ser Gly  Phe Lys Ile Gly Asp  Arg Val Ala 
    1805                 1810                 1815             


Gly Phe  Gly Ala Gly Thr Val  Ala Thr Leu Tyr Arg  Asp Gln Ala 
    1820                 1825                 1830             


Ala Arg  Phe Gln Leu Ile Pro  Asp Asp Met Ser Phe  Ala Arg Ala 
    1835                 1840                 1845             


Ala Ala  Leu Pro Val Ala Tyr  Ile Thr Ala Phe Phe  Ala Val His 
    1850                 1855                 1860             


Ala Leu  Gly Gln Val Ser Arg  Gly Asp Arg Val Leu  Ile Gln Asp 
    1865                 1870                 1875             


Ala Gly  Thr Ala Ala Gly Gln  Ala Leu Leu Glu Leu  Cys Ala Leu 
    1880                 1885                 1890             


Ala Gly  Gly Asp Ile Ile Ala  Val Val Asp Ser Pro  Ser Gln Arg 
    1895                 1900                 1905             


Ala Phe  Leu Val Gly Glu Tyr  Asp Leu Pro Ala Ser  Arg Ile Leu 
    1910                 1915                 1920             


Val Gly  Leu Arg Gly Arg Arg  Leu Ala Thr Ser Val  Met Thr Leu 
    1925                 1930                 1935             


Thr Arg  Gly Cys Gly Val Asp  Ala Ile Phe Asn Phe  Arg Gly Gly 
    1940                 1945                 1950             


Glu Glu  Arg Arg Leu Cys Trp  Ser Cys Val Ala Pro  Tyr Gly Arg 
    1955                 1960                 1965             


Phe Ile  Asp Leu Gly Gly Gly  Pro Ser Asp Leu Thr  Asp Met Thr 
    1970                 1975                 1980             


Gln Leu  Glu Met Ala Ser Phe  Phe Ser Lys Asn Ala  Ser Phe Thr 
    1985                 1990                 1995             


Ala Leu  Asp Phe His Tyr Leu  Val Thr Arg Lys Pro  Asn Ala Val 
    2000                 2005                 2010             


Glu Arg  Ile Trp Ser Asp Val  Met Ala Leu Val Arg  Ala Lys Ala 
    2015                 2020                 2025             


Ile Arg  Gly Pro Pro Arg Leu  Gln Leu His Ser Val  Ser Glu Val 
    2030                 2035                 2040             


Glu Thr  Ala Leu Lys Gln Ser  Gln Asp Gly Cys Asp  Val Glu Lys 
    2045                 2050                 2055             


Val Val  Ile Arg Ala Glu Arg  Asp Thr Ile Val Gln  Ala Ile Pro 
    2060                 2065                 2070             


Pro Pro  Lys Gly Asp Leu Leu  Arg Ala Asp Ala Ser  Tyr Val Leu 
    2075                 2080                 2085             


Val Gly  Gly Leu Gly Gly Ile  Gly Arg Ala Met Ala  Ser Trp Met 
    2090                 2095                 2100             


Ile Ala  Asn Gly Ala Arg His  Leu Ile Phe Val Asn  Arg Ser Gly 
    2105                 2110                 2115             


Leu Ala  Arg Asn Ala Ala Arg  Glu Thr Val Glu Ser  Leu Glu Gly 
    2120                 2125                 2130             


His Gly  Ala His Val Ala Val  Tyr Ser Cys Asp Val  Ser Asp Arg 
    2135                 2140                 2145             


Asp Gln  Val Ala Gln Met Val  Ala Gln Ser Ser Lys  Glu Val Pro 
    2150                 2155                 2160             


Pro Ile  Arg Gly Val Ile Gln  Ala Ala Met Ile Leu  Arg Asp Met 
    2165                 2170                 2175             


Leu Phe  Glu Lys Met Ser Val  Asp Asp Phe Asn Thr  Val Leu Gln 
    2180                 2185                 2190             


Pro Lys  Trp Gln Gly Thr Trp  Asn Leu His Gly Leu  Leu Pro Arg 
    2195                 2200                 2205             


Asp Met  Asp Phe Phe Ile Met  Leu Ser Ser Ile Ser  Gly Val Ile 
    2210                 2215                 2220             


Gly Asn  Ala Thr Gln Ala Ala  Tyr Ala Ala Gly Ser  Thr Phe Leu 
    2225                 2230                 2235             


Gly Ala  Phe Ala Gln Tyr Arg  Ser Ser Ala Gly Leu  Pro Ala Val 
    2240                 2245                 2250             


Thr Leu  Asp Leu Gly Val Ile  Thr Gly Ile Gly Tyr  Leu Ser Glu 
    2255                 2260                 2265             


His Glu  Ala Leu Leu Gln Gly  Met Gln Arg Leu Gly  Phe Glu Gly 
    2270                 2275                 2280             


Thr Asn  Glu Gln Thr Leu Met  Ala Leu Ile Arg Ser  Ala Ile Val 
    2285                 2290                 2295             


Ser Pro  Arg Arg Thr Gly Ser  Gln Ala Glu Ile Val  Thr Gly Leu 
    2300                 2305                 2310             


Gly Thr  Trp Lys Glu Gly Val  Ser Asn Gly Asn Ala  Asp Gln Pro 
    2315                 2320                 2325             


Leu Phe  Ala His Phe Cys Arg  Gln Arg Leu Gly Leu  Arg Asp Ala 
    2330                 2335                 2340             


Thr Ala  Glu Gly Thr Gly Gly  Ser Val Arg Glu Ser  Leu Arg Gly 
    2345                 2350                 2355             


Cys Thr  Thr Leu Asp Asp Ala  Thr Arg Leu Val Cys  Ala His Leu 
    2360                 2365                 2370             


Ile Asp  Arg Leu Ala Ala Arg  Leu Asn Thr Pro Val  Asp Asn Ile 
    2375                 2380                 2385             


Asp Ser  Gln Arg Ala Met Ser  Glu Tyr Gly Val Asp  Ser Leu Val 
    2390                 2395                 2400             


Ala Val  Glu Met Arg Asn Trp  Ile Gly Lys Glu Met  Glu Ser Thr 
    2405                 2410                 2415             


Met Pro  Ile Leu Glu Leu Leu  Ala Asn Gln Ser Ile  Ser Gln Leu 
    2420                 2425                 2430             


Ser Arg  Lys Ile Ala Gln Arg  Ser Lys Val Val Ala  Ser Ser Gly 
    2435                 2440                 2445             


Ser Glu  Glu 
    2450     


<210>  16
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 14

<400>  16

Met Val Glu Asn Val Ser Ser Pro Ser Ser Pro Arg Thr Ala Ser Pro 
1               5                   10                  15      


Ser Gly Ser Cys Thr Pro Gly Ser Ala Gln Ser Val Gly Arg Asp Asp 
            20                  25                  30          


Lys Ser Met Pro Ile Ala Val Val Gly Met Ser Phe Arg Gly Pro Arg 
        35                  40                  45              


Asp Ala Ile Ser Val Glu Ser Leu Trp Arg Met Ile Ser Glu Gly Arg 
    50                  55                  60                  


Glu Gly Trp Ser Lys Ile Pro Lys Ser Arg Trp Asn Asp Asp Ala Phe 
65                  70                  75                  80  


Tyr His Pro Asp His Ser Arg Thr Gly Thr Ile Asn Val Glu Arg Gly 
                85                  90                  95      


His Phe Leu Glu Glu Asp Leu Ala Arg Phe Asp Ala Glu Phe Phe Asn 
            100                 105                 110         


Met Thr Asn Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Leu Leu 
        115                 120                 125             


Leu Glu Ser Thr Phe Glu Ala Val Glu Asn Ala Gly Ile Pro Leu Asp 
    130                 135                 140                 


Lys Met Leu Gly Ser Lys Thr Ser Cys Phe Val Gly Ser Phe Cys Gly 
145                 150                 155                 160 


Asp Tyr Thr Asp Met Leu Val Arg Asp Pro Glu Ala Ile Pro Gly Tyr 
                165                 170                 175     


Gln Cys Thr Asn Ala Gly Gln Ser Arg Ala Ile Thr Ala Asn Arg Val 
            180                 185                 190         


Ser Tyr Lys Phe Asp Leu Arg Gly Pro Ser Val Thr Val Asp Thr Ala 
        195                 200                 205             


Cys Ser Gly Ser Leu Val Ala Leu His Leu Ala Cys Gln Ser Leu Arg 
    210                 215                 220                 


Thr Gly Asp Ala Lys Met Ala Ile Val Ser Gly Val Asn Thr Ile Leu 
225                 230                 235                 240 


Ser His Glu Leu Met Ser Thr Met Ser Met Met Arg Phe Leu Ser Pro 
                245                 250                 255     


Asp Gly Arg Cys Tyr Thr Phe Asp Glu Arg Ala Asn Gly Tyr Ala Arg 
            260                 265                 270         


Gly Glu Gly Val Gly Cys Leu Leu Leu Lys Pro Leu Ser Asp Ala Leu 
        275                 280                 285             


Arg Asp Asn Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn 
    290                 295                 300                 


Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu Pro Asn Ala Asn Ala Gln 
305                 310                 315                 320 


Gln Glu Leu Ile Arg Asp Val Tyr Ala Ala Ala Gly Leu Asp Pro Leu 
                325                 330                 335     


Glu Thr Glu Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp 
            340                 345                 350         


Pro Leu Glu Thr Gly Ala Val Ile Lys Val Phe Ser Pro Gly Arg Pro 
        355                 360                 365             


Asp Asp Gln Pro Leu Arg Ile Gly Ser Ile Lys Thr Asn Val Gly His 
    370                 375                 380                 


Leu Glu Gly Ala Ser Gly Ile Ala Gly Val Ile Lys Ala Val Leu Thr 
385                 390                 395                 400 


Leu Glu Asn Gln Cys Phe Leu Pro Asn Arg Asn Phe Lys Ser Ile Asn 
                405                 410                 415     


Pro Arg Ile Pro Leu Lys Glu Trp Lys Leu Lys Ile Gln Leu Glu Asn 
            420                 425                 430         


Glu Arg Trp Glu Thr Val Gly Pro His Arg Val Ser Val Asn Ser Phe 
        435                 440                 445             


Gly Tyr Gly Gly Ser Asn Ala His Ala Val Leu Glu Asp Thr Lys Gly 
    450                 455                 460                 


Tyr Leu Glu Gln Arg Ser Leu Gln Gly Ser Phe Arg Arg Val Arg His 
465                 470                 475                 480 


Leu Pro Pro Ala Ala Thr Asp Leu Glu Pro Val Pro Asp Arg Pro Ser 
                485                 490                 495     


Gly Pro Glu Arg Thr Ala Leu Phe Val Leu Ser Ser Phe Asp Gln Ala 
            500                 505                 510         


Ser Gly Gln Gln Gln Ile Asp Gln Leu Arg Glu Tyr Leu Glu Gln Asn 
        515                 520                 525             


Ser Glu Arg Ile Asp Asp Gln Tyr Leu Ala Asp Leu Ala Tyr Thr Leu 
    530                 535                 540                 


Gly Glu Arg Arg Ser Pro Phe Leu Trp Lys Thr Ala Met Pro Ala Ser 
545                 550                 555                 560 


Ser Val Ser Ser Leu Val Glu Gly Leu Lys Thr Arg Gln Val Val Ser 
                565                 570                 575     


Arg Ala Glu Lys Lys Lys Pro Thr Leu Gly Phe Ile Phe Thr Gly Gln 
            580                 585                 590         


Gly Ala Gln Trp Cys Gly Met Gly Arg Glu Leu Leu Ala Ala Tyr Pro 
        595                 600                 605             


Val Phe Ala Ser Ser Val Asp Ala Ile Ala Thr Tyr Leu Lys Gly Leu 
    610                 615                 620                 


Gly Ala Pro Phe Asp Val Arg Glu Glu Leu Val Arg Asp Pro Lys Asp 
625                 630                 635                 640 


Ser Lys Ile Asn Gln Pro Leu Tyr Ser Gln Pro Ile Cys Thr Ala Val 
                645                 650                 655     


Gln Ile Ala Leu Val Asp Leu Leu Thr Phe Trp Gly Ile Arg Pro Ala 
            660                 665                 670         


Ser Val Thr Gly His Ser Ser Gly Glu Leu Ala Gly Ala Tyr Thr Ala 
        675                 680                 685             


Gly Ala Leu Ser Met Glu His Ser Met Ala Ala Ala Tyr Val Arg Gly 
    690                 695                 700                 


Val Ala Ser Ser Glu Leu Pro Arg Asp His Thr Gln Arg Gly Ala Met 
705                 710                 715                 720 


Met Ala Val Gly Ala Ser Lys Asp Ala Ile Gln Pro Arg Leu Ser Ser 
                725                 730                 735     


Leu Thr Thr Gly Thr Ala Val Val Ala Cys Val Asn Ser Pro Ser Ser 
            740                 745                 750         


Val Thr Ile Ser Gly Asp Ala Ser Ala Val Asp Glu Leu His Gly Val 
        755                 760                 765             


Leu Glu Lys Asp Gln Val Phe Ala Arg Lys Leu Ala Val Asp Val Ala 
    770                 775                 780                 


Tyr His Ser His His Met Lys Ala Val Ala Asp Gln Tyr Arg Thr Ala 
785                 790                 795                 800 


Met Ala Ala Ala Gly Val Thr Ala Ser Gln Pro Glu Ser Arg Glu Pro 
                805                 810                 815     


Glu Val Glu Phe Phe Ser Ser Val Thr Gly Glu Leu Ala Ser Leu Thr 
            820                 825                 830         


Asp Leu Gly Ile Glu Tyr Trp Val Ala Asn Leu Leu Ser Gln Val Lys 
        835                 840                 845             


Phe Ala Asp Ser Val His Arg Leu Cys Met Glu Thr Ser Ala Ser Gly 
    850                 855                 860                 


Arg Gln Arg Lys Thr Lys Thr Lys Ala Pro Lys Arg Ser Gly Ala Asn 
865                 870                 875                 880 


Asn Lys Ala Lys Val Asp Met Leu Val Glu Ile Gly Pro His Ser Thr 
                885                 890                 895     


Leu Ala Gly Pro Ile Arg Gln Ile Leu Gly Ala Asp Gln Thr Leu Glu 
            900                 905                 910         


Gln Ala Ser Ile Arg Tyr Ala Ser Ala Leu Leu Arg Lys Ser Ser Ala 
        915                 920                 925             


Tyr Asp Thr Thr Leu Thr Leu Ala Ser Thr Leu Leu Met Ala Gly Tyr 
    930                 935                 940                 


Pro Ile Asp Met Ala Ala Ile Asn Asn Pro Ser Asp Thr His Arg Val 
945                 950                 955                 960 


Ala Val Leu Val Asp Leu Pro Pro Tyr Pro Trp Asn His Ser Gly Ser 
                965                 970                 975     


Tyr Trp Ala Glu Pro Arg Ile Ser Lys Ala Tyr Arg Asn Arg Ala His 
            980                 985                 990         


Pro Arg Asn Asp Leu Leu Gly Val  Leu Asp Thr His Ser  Ser Gly Arg 
        995                 1000                 1005             


Glu Pro  Arg Trp Arg Asn Tyr  Leu Arg Thr Ser Glu  Ile Pro Trp 
    1010                 1015                 1020             


Ile Lys  Asp His Met Ile Gln  Ser Asn Val Val Tyr  Pro Ala Ala 
    1025                 1030                 1035             


Gly Tyr  Leu Thr Met Ala Val  Glu Ala Ile Gly Gln  Arg Ile Gly 
    1040                 1045                 1050             


Asp Asn  Phe Pro Gly His Arg  Ile Ser Gly Tyr Arg  Leu Arg Asp 
    1055                 1060                 1065             


Val Thr  Ile Glu Ala Ala Leu  Val Ile Ser Asp Asp  Ser Glu Pro 
    1070                 1075                 1080             


Glu Val  Met Leu Val Leu Arg  Pro Ser Leu Ile Ser  Gly Leu Val 
    1085                 1090                 1095             


Pro Ala  Glu Arg Trp His Glu  Phe His Val Leu Ser  Val Thr Pro 
    1100                 1105                 1110             


Asp Asn  Arg Trp Thr Glu His  Cys Arg Gly Leu Ile  Cys Ala Glu 
    1115                 1120                 1125             


Val Pro  Ala Met Asp Ala Arg  Glu Asp Asp Arg Gly  Ala Glu Ala 
    1130                 1135                 1140             


Ala Tyr  Thr Ala Glu Thr Glu  Arg Trp Ile Glu Glu  Ala Glu Gln 
    1145                 1150                 1155             


Leu Cys  Gln Lys Asp Val Asp  Ile Pro Arg Phe Tyr  Ala Glu Leu 
    1160                 1165                 1170             


Thr Gly  Leu Gly Leu Glu Tyr  Gly Glu Thr Phe Ala  Asn Met Thr 
    1175                 1180                 1185             


Arg Ala  Arg Ser Ala Ser His  Val Cys Leu Ala Glu  Ile Glu Val 
    1190                 1195                 1200             


Ala Asp  Thr Arg Ala Val Met  Pro His Gly Phe Gln  Phe Asn Phe 
    1205                 1210                 1215             


Val Val  His Pro Ser Thr Leu  Asp Ser Leu Phe His  Pro Leu Phe 
    1220                 1225                 1230             


Val Ala  Leu Gln Ser Asp Glu  Ser Leu Gln Asp Pro  Ala Val Pro 
    1235                 1240                 1245             


Val Ala  Ile Glu Glu Ile Trp  Ile Arg His Gly Met  Ala Lys Glu 
    1250                 1255                 1260             


Ala Gly  Ser Lys Phe Gln Val  Cys Ala Lys Thr Gln  Glu Asn Gly 
    1265                 1270                 1275             


Arg Asp  Gln Ile Gln Ala Ala  Ile Ala Val Val Asp  Ala Gln Arg 
    1280                 1285                 1290             


Ala Arg  Ser Gly Pro Ala Leu  Thr Val Arg Gly Leu  Thr Cys Gln 
    1295                 1300                 1305             


Phe Leu  Asp Arg Ala Ala Gly  Asp Gln Glu Gly Asp  Glu Gln Thr 
    1310                 1315                 1320             


Thr Arg  Leu Ala Tyr Glu Leu  His Trp Arg Ala Asp  Val Ala Leu 
    1325                 1330                 1335             


Leu Ser  Ser Ser Asp Leu Ala  Thr Leu Cys Ala Val  Gly Arg Pro 
    1340                 1345                 1350             


Arg Asp  Val Glu Glu Ala Val  Ala Arg Tyr Val Lys  Leu Leu Gly 
    1355                 1360                 1365             


His Lys  Asn Pro His Leu Ala  Ile Leu Glu Val Gly  Ala Gly Gln 
    1370                 1375                 1380             


Gly Glu  Leu Cys Ile Pro Val  Phe Arg Ala Leu Ala  Gly Glu Ala 
    1385                 1390                 1395             


Asn Ser  Thr Pro Ser Phe Gln  Thr Tyr Thr Leu Ala  Asp Thr Glu 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Thr Ile  Asp Thr Ile Ala Asp  Gln Phe Asn 
    1415                 1420                 1425             


Glu Arg  Ser Asp Leu Ile His  Tyr Lys Glu Leu Asp  Ile Ser Ser 
    1430                 1435                 1440             


Asp Pro  Val Gln Gln Gly Phe  Asn Ala His Ser Leu  Asp Leu Ile 
    1445                 1450                 1455             


Leu Leu  Pro Ala Arg Gly Val  Ser Ala Thr Val Arg  Ser Lys Ile 
    1460                 1465                 1470             


Leu Lys  His Ala His Gln Leu  Leu Thr Pro Glu Gly  Arg Leu Ile 
    1475                 1480                 1485             


Val Leu  Asp Thr Arg Asp Leu  Gln Glu Trp Asp Gln  Ala Leu Arg 
    1490                 1495                 1500             


Glu Ser  Asn Phe Thr Asp Pro  Glu Val Ile His Asp  Ser Pro Ser 
    1505                 1510                 1515             


Pro Thr  Glu Ala Asp Ile Ser  Val Leu Val Ser Lys  Pro Met Pro 
    1520                 1525                 1530             


Gln Pro  Arg Asp Gln Thr Pro  Ser Asp Pro Pro Asp  Val Leu Val 
    1535                 1540                 1545             


Ile Ala  Glu Val Gln Asp Ser  Gly Val Ser Ile Glu  His Leu Leu 
    1550                 1555                 1560             


Arg His  Leu Ala Asp Ala His  Val Pro Ala Thr Val  Thr Asp Phe 
    1565                 1570                 1575             


Ala His  Leu Ala Pro Glu Met  Met Thr Cys Ile Val  Leu Ser Glu 
    1580                 1585                 1590             


Leu Thr  Gly Ser Leu Leu Ser  His Pro Asp Gln His  Ser Phe Glu 
    1595                 1600                 1605             


Ser Leu  Lys Arg Ile Leu Val  Ala Gly Gly Arg Gly  Val Leu Trp 
    1610                 1615                 1620             


Val Val  Arg Gly Ala Glu Gly  Glu Ala Pro Ser Ser  Ser Leu Ala 
    1625                 1630                 1635             


Thr Gly  Leu Leu Arg Thr Ile  Arg Ser Glu Thr Asp  Asp Asp Arg 
    1640                 1645                 1650             


Pro Ile  Val Ser Leu Asp Leu  Asp Ala Ser Asp Pro  Leu Ala Ala 
    1655                 1660                 1665             


Ala Ser  Ala Ala Gln Ser Ile  Phe Ser Ala Phe Arg  His Gly Phe 
    1670                 1675                 1680             


Met Ser  Pro Gly Gly Ser Ala  Glu Val Glu Tyr Ala  Glu Arg Asp 
    1685                 1690                 1695             


Gly Ile  Leu Arg Ile Pro Arg  Val Val Glu Ser Ser  Leu Val Asn 
    1700                 1705                 1710             


His Glu  Ile Val Ser Ser Leu  Arg Pro Ala Val Ala  Glu Asp Gln 
    1715                 1720                 1725             


Pro Phe  Phe Val Ser Gly Arg  Pro Leu Glu Leu Thr  Val Gly Ala 
    1730                 1735                 1740             


Pro Gly  Arg Leu Asp Ser Leu  Tyr Tyr Val Asp Arg  Ser Asp Ile 
    1745                 1750                 1755             


Ser Glu  Leu Pro Ser Asp Tyr  Val Glu Ile Glu Val  Lys Ala Ile 
    1760                 1765                 1770             


Gly Leu  Gly Asn Gly Asp Val  Lys Thr Ala Leu Gly  His Asp Asp 
    1775                 1780                 1785             


Ala Ala  Thr Pro Leu Gly Ala  Glu Cys Ser Gly Val  Val Thr Ala 
    1790                 1795                 1800             


Leu Gly  Asp Ala Val Ser Gly  Phe Lys Ile Gly Asp  Arg Val Ala 
    1805                 1810                 1815             


Gly Phe  Gly Ala Gly Thr Val  Ala Thr Leu Tyr Arg  Asp Gln Ala 
    1820                 1825                 1830             


Ala Arg  Phe Gln Leu Ile Pro  Asp Asp Met Ser Phe  Ala Arg Ala 
    1835                 1840                 1845             


Ala Ala  Leu Pro Val Ala Tyr  Ile Thr Ala Phe Phe  Ala Val His 
    1850                 1855                 1860             


Ala Leu  Gly Gln Val Ser Arg  Gly Asp Arg Val Leu  Ile Gln Asp 
    1865                 1870                 1875             


Ala Gly  Thr Ala Ala Gly Gln  Ala Leu Leu Glu Leu  Cys Ala Tyr 
    1880                 1885                 1890             


Ala Gly  Gly Asp Ile Ile Ala  Val Val Asp Ser Pro  Ser Gln Arg 
    1895                 1900                 1905             


Ala Phe  Leu Val Gly Glu Tyr  Asp Leu Pro Ala Ser  Arg Ile Leu 
    1910                 1915                 1920             


Val Gly  Leu Arg Gly Arg Arg  Leu Ala Thr Ser Val  Met Thr Leu 
    1925                 1930                 1935             


Thr Arg  Gly Cys Gly Val Asp  Ala Ile Phe Asn Phe  Arg Gly Gly 
    1940                 1945                 1950             


Glu Glu  Arg Gln Leu Cys Trp  Ser Cys Val Ala Pro  Tyr Gly Arg 
    1955                 1960                 1965             


Phe Ile  Asp Leu Gly Gly Gly  Pro Ser Asp Leu Lys  Asp Met Pro 
    1970                 1975                 1980             


Gln Leu  Glu Met Ala Ser Arg  Phe Ser Lys Asn Ala  Ser Phe Thr 
    1985                 1990                 1995             


Ala Leu  Asp Phe His Tyr Leu  Val Thr Gln Lys Pro  Gln Ala Val 
    2000                 2005                 2010             


His Arg  Ile Trp Ser Asp Val  Met Ala Leu Val Arg  Ala Lys Ala 
    2015                 2020                 2025             


Ile Arg  Gly Pro Pro Arg Leu  Gln Leu His Ser Val  Ser Glu Val 
    2030                 2035                 2040             


Glu Thr  Ala Leu Lys Gln Ser  Gln Asp Gly Cys Asp  Val Glu Lys 
    2045                 2050                 2055             


Val Val  Ile Arg Ala Glu Arg  Asp Thr Lys Val Gln  Ala Leu Pro 
    2060                 2065                 2070             


Pro Pro  Lys Gly Gln Leu Leu  Arg Ala Asp Ala Ser  Tyr Val Leu 
    2075                 2080                 2085             


Val Gly  Gly Leu Gly Gly Ile  Gly Arg Ala Met Ala  Ser Trp Met 
    2090                 2095                 2100             


Ile Ala  Thr Gly Ala Arg His  Leu Ile Phe Val Asn  Arg Ser Gly 
    2105                 2110                 2115             


Leu Arg  Arg Asn Glu Ala Arg  Glu Thr Val Glu Ser  Leu Ile Gly 
    2120                 2125                 2130             


His Gly  Ala His Val Ala Val  Tyr Ser Cys Asp Val  Ser Asp Arg 
    2135                 2140                 2145             


Asp Gln  Val Ala Gln Met Val  Ala Ala Ser Ser Lys  Glu Met Pro 
    2150                 2155                 2160             


Pro Ile  Arg Gly Val Ile Gln  Ala Ala Met Ile Leu  Asp Asp Ala 
    2165                 2170                 2175             


Leu Phe  Glu Lys Met Ser Val  Asp Asp Phe Asn Thr  Val Leu Gln 
    2180                 2185                 2190             


Pro Lys  Trp Gln Gly Thr Trp  Asn Leu His Gly Leu  Leu Pro Arg 
    2195                 2200                 2205             


Tyr Met  Asp Phe Phe Ile Met  Leu Ser Ser Ile Ser  Gly Val Ile 
    2210                 2215                 2220             


Gly Asn  Ala Thr Gln Ala Ala  Tyr Ala Ala Gly Ser  Thr Phe Leu 
    2225                 2230                 2235             


Gly Ala  Phe Ala Gln Tyr Arg  Ser Ser Leu Gly Leu  Pro Ala Val 
    2240                 2245                 2250             


Thr Leu  Asp Leu Gly Val Ile  Thr Gly Ile Gly Ala  Leu Ser Glu 
    2255                 2260                 2265             


His Glu  Glu Leu Leu Gln Gly  Met Gln Arg Gln Gly  Phe Glu Gly 
    2270                 2275                 2280             


Thr Arg  Glu Gln Thr Leu Met  Ala Leu Ile Arg Ser  Ala Ile Val 
    2285                 2290                 2295             


Ser Pro  Arg Arg Thr Gly Asp  Gln Ala Glu Ile Val  Thr Gly Leu 
    2300                 2305                 2310             


Gly Thr  Trp Arg Glu Gly Val  Leu Leu Gly Asn Phe  Asp Gln Pro 
    2315                 2320                 2325             


Leu Phe  Ala His Phe Arg Arg  Gln Ala Leu Gly Leu  Arg Asp Ala 
    2330                 2335                 2340             


Thr Ala  Glu Gly Pro Gly Asp  Ser Val Thr Glu Ser  Leu Arg Gly 
    2345                 2350                 2355             


Cys Lys  Thr Leu Asp Asp Ala  Leu Ala Leu Val Cys  Ala Ala Leu 
    2360                 2365                 2370             


Ile Asp  Arg Leu Ala Ser Arg  Leu Asn Thr Pro Pro  Asp Asn Ile 
    2375                 2380                 2385             


Asp Ser  Gln Arg Ala Met Ser  Glu Tyr Gly Val Asp  Ser Leu Val 
    2390                 2395                 2400             


Ala Val  Glu Met Arg Asn Trp  Ile Gly Lys Glu Met  Glu Ser Thr 
    2405                 2410                 2415             


Met Pro  Ile Leu Glu Leu Leu  Ala Asn Gln Ser Ile  Glu Gln Leu 
    2420                 2425                 2430             


Ser Glu  Glu Ile Ala Gln Arg  Ser Lys Val Val Lys  Val Ser Gly 
    2435                 2440                 2445             


Ser Glu  Glu 
    2450     


<210>  17
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 14

<400>  17

Met Val Glu Asn Val Ser Ser Pro Ser Ser Pro Arg Thr Ser Ser Pro 
1               5                   10                  15      


Ser Gly Ser Cys Thr Pro Thr Ser Ala Thr Ser Val Gly Ser Asp Ala 
            20                  25                  30          


Lys Ser Met Pro Ile Ala Val Val Gly Met Ser Phe Arg Gly Pro Arg 
        35                  40                  45              


Asp Ala Ile Ser Val Glu Ser Leu Trp Arg Met Ile Ala Glu Gly Arg 
    50                  55                  60                  


Glu Gly Trp Ser Lys Ile Pro Lys Ser Arg Trp Asn Asn Asp Ala Phe 
65                  70                  75                  80  


Tyr His Pro Asp His Ser Arg His Gly Thr Ile Asn Val Glu Gly Gly 
                85                  90                  95      


His Phe Leu Glu Glu Asp Leu Ala Arg Phe Asp Ala Pro Phe Phe Asn 
            100                 105                 110         


Met Thr Asn Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Leu Leu 
        115                 120                 125             


Leu Glu Ser Thr Phe Glu Ala Val Glu Asn Ala Gly Ile Pro Leu Asp 
    130                 135                 140                 


Lys Met Leu Gly Ser Lys Thr Ser Cys Phe Val Gly Ser Asn Ala Asn 
145                 150                 155                 160 


Asp Tyr Val Asp Met Leu Phe Arg Asp Pro Glu Ala Ile Pro Met Tyr 
                165                 170                 175     


Gln Cys Thr Asn Ala Gly Gln Ser Gly Ala Ile Thr Ala Asn Arg Val 
            180                 185                 190         


Ser Tyr Phe Phe Asp Leu Arg Gly Pro Ser Val Thr Val Asp Thr Ala 
        195                 200                 205             


Cys Ser Gly Ser Leu Val Ala Leu His Leu Ala Cys Gln Ser Leu Arg 
    210                 215                 220                 


Thr Gly Asp Ala Lys Met Ala Ile Val Ser Gly Val Asn Thr Ile Leu 
225                 230                 235                 240 


Ser His Tyr Phe Met Ser Thr Met Ser Met Met Arg Phe Leu Ser Pro 
                245                 250                 255     


Asp Gly Arg Cys Tyr Thr Phe Asp Glu Arg Ala Asn Gly Tyr Ala Arg 
            260                 265                 270         


Gly Glu Gly Val Gly Cys Leu Leu Leu Lys Pro Leu Ser Asp Ala Leu 
        275                 280                 285             


Arg Asp Asn Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn 
    290                 295                 300                 


Gln Asp Gly Lys Thr Lys Gly Ile Thr Leu Pro Asn Ala Asn Ala Gln 
305                 310                 315                 320 


Gln Glu Leu Ile Arg Asp Val Tyr Ala Ala Ala Gly Leu Asp Pro Leu 
                325                 330                 335     


Glu Thr Glu Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp 
            340                 345                 350         


Pro Leu Glu Thr Gly Ala Val Ala Lys Val Phe Ser Pro Arg Arg Lys 
        355                 360                 365             


Asp Asp Arg Pro Leu Arg Ile Gly Ser Ile Lys Thr Asn Val Gly His 
    370                 375                 380                 


Leu Glu Gly Ala Ser Gly Ile Ala Gly Val Ile Lys Ala Val Leu Thr 
385                 390                 395                 400 


Leu Glu Asn Gln Cys Phe Leu Pro Asn Arg Asn Phe Lys Ser Ile Asn 
                405                 410                 415     


Pro Arg Ile Pro Leu Thr Glu Trp Lys Leu Arg Ile Gln Leu Glu Asn 
            420                 425                 430         


Glu Arg Trp Glu Thr Val Gly Pro His Arg Val Ser Val Asn Ser Phe 
        435                 440                 445             


Gly Tyr Gly Gly Ser Asn Ala His Ala Val Leu Glu Asp Thr Lys Gly 
    450                 455                 460                 


Tyr Leu Lys Gln Arg Ser Leu Thr Gly Ser Gly Arg Glu Val Arg Ala 
465                 470                 475                 480 


Leu Ser His Ala Val Thr Asp Leu Glu Pro Val Ser Thr Pro Gly Ser 
                485                 490                 495     


Gly Pro Glu Arg Thr Arg Leu Phe Val Leu Ser Ser Phe Asp Gln Ala 
            500                 505                 510         


Ser Gly Gln Gln Gln Ile Asp Gln Leu Arg Glu Tyr Leu Glu Gln Asn 
        515                 520                 525             


Ser Gln Arg Glu Asp Asp Gln Tyr Leu Ala Asp Leu Ala Tyr Thr Leu 
    530                 535                 540                 


Gly Glu Arg Arg Ser Pro Phe Leu Trp Lys Thr Ala Met Pro Ala Ser 
545                 550                 555                 560 


Ser Val Ser Ser Leu Val Glu Gly Leu Lys Thr Arg Ala Lys Val Ser 
                565                 570                 575     


Arg Ala Glu Lys Lys Lys Pro Thr Leu Gly Phe Ile Phe Thr Gly Gln 
            580                 585                 590         


Gly Ala Gln Trp Cys Gly Met Gly Arg Glu Leu Leu Ala Thr Tyr Pro 
        595                 600                 605             


Val Phe Ala Ser Ser Val Asp Ala Ile Ala Thr Tyr Leu Lys Ser Leu 
    610                 615                 620                 


Gly Ala Pro Phe Asp Val Leu Glu Glu Leu Val Arg Asp Pro Lys Asp 
625                 630                 635                 640 


Ser Lys Ile Asn Gln Pro Leu Tyr Ser Gln Pro Ile Cys Thr Ala Val 
                645                 650                 655     


Gln Ile Ala Leu Val Asp Leu Leu Thr Phe Trp Gly Ile Arg Pro Ala 
            660                 665                 670         


Ser Val Thr Gly His Ser Ser Gly Glu Leu Ala Gly Ala Tyr Thr Ala 
        675                 680                 685             


Gly Ala Leu Ser Met Glu His Ser Met Ala Ala Ala Tyr Tyr Arg Gly 
    690                 695                 700                 


Val Ala Ser Gln Lys Leu Pro Arg Asp Asn Asp Gln Arg Gly Ala Met 
705                 710                 715                 720 


Met Ala Val Gly Ala Ser Lys Asp Ala Ile Gln Pro Arg Leu Asp Ser 
                725                 730                 735     


Leu Thr Val Gly Thr Ala Val Val Ala Cys Val Asn Ser Pro Ser Ser 
            740                 745                 750         


Val Thr Ile Ser Gly Asp Ala Ser Ala Val Asp Glu Leu Leu Gly Leu 
        755                 760                 765             


Leu Glu Lys Asp Gln Val Phe Ala Arg Lys Leu Ala Val Asp Val Ala 
    770                 775                 780                 


Tyr His Ser His His Met Lys Ala Val Ala Asp Gln Tyr Arg Thr Ala 
785                 790                 795                 800 


Met Ala Ser Ala Gly Val Thr Ala Val Gln Pro Glu Ser Thr Glu Pro 
                805                 810                 815     


Arg Val Glu Phe Phe Ser Ser Val Thr Gly Glu Tyr Ala Ser Pro Ala 
            820                 825                 830         


Asp Leu Gly Ile Glu Tyr Trp Val Ala Asn Leu Leu Ser Gln Val Lys 
        835                 840                 845             


Phe Ala Asp Ser Val His Arg Leu Cys Gly Glu Thr Ser Ala Ser Gly 
    850                 855                 860                 


Arg His Arg Lys Thr Lys Thr Lys Ala Pro Lys Arg Ser Gly Ala Asn 
865                 870                 875                 880 


Asn Lys Ala Lys Val His Met Leu Val Glu Ile Gly Pro His Ser Thr 
                885                 890                 895     


Leu Ala Gly Pro Ile Arg Gln Ile Leu Gly Ala Leu Leu Asn Leu Glu 
            900                 905                 910         


Arg Ala Ser Ile Thr Tyr Ala Ser Ala Leu Leu Arg Lys Ser Ser Ala 
        915                 920                 925             


Val Glu Thr Thr Leu Thr Leu Ala Ser Thr Leu Leu Met Ala Gly Tyr 
    930                 935                 940                 


Pro Ile Asp Met Ala Ala Ile Asn Arg Pro Ser Asp His Lys Arg Glu 
945                 950                 955                 960 


Gly Val Leu Val Asp Leu Pro Pro Tyr Pro Trp Asn His Ser Gly Ser 
                965                 970                 975     


Tyr Trp Ala Glu Pro Arg Lys Ser Lys Asp Tyr Arg Asn Arg Gly His 
            980                 985                 990         


Pro Arg Asn Asp Leu Leu Gly Val  Leu Asp Thr His Ser  Ser Pro Glu 
        995                 1000                 1005             


Glu Pro  Arg Trp Arg Asn Tyr  Leu Arg Thr Ser Glu  Ile Pro Trp 
    1010                 1015                 1020             


Ile Lys  Asp His Met Ile Gln  Ser Asn Val Val Tyr  Pro Ala Ala 
    1025                 1030                 1035             


Gly Tyr  Leu Thr Met Ala Val  Glu Ala Ile Gly Gln  Arg Ile Gly 
    1040                 1045                 1050             


Asp Asn  Phe Lys Leu His Arg  Ile Ser Gly Val Arg  Leu Arg Asp 
    1055                 1060                 1065             


Val Thr  Ile Glu Ala Ala Leu  Val Ile Ser Asp Asp  Ser Glu Pro 
    1070                 1075                 1080             


Glu Val  Met Leu Ser Leu Asp  Pro Gln Gly Arg Ser  Lys Leu Val 
    1085                 1090                 1095             


Gln Ala  Glu Arg Trp His Glu  Phe His Val Leu Ser  His Pro Asn 
    1100                 1105                 1110             


Asp Asn  Arg Trp Thr Glu His  Cys Arg Gly Leu Ile  Cys Ala Ser 
    1115                 1120                 1125             


Val Gly  Thr Met Asp Trp Asp  Glu Gly Asp Arg Gly  Ala Glu Ala 
    1130                 1135                 1140             


Gly Leu  Thr Ala Glu Thr Glu  Arg Trp Ile Glu Glu  Ala Glu Gln 
    1145                 1150                 1155             


Leu Cys  Ser Lys Asp Val Asp  Ile Pro Arg Phe Tyr  Ala Arg Leu 
    1160                 1165                 1170             


Thr Asp  Arg Gly Leu Glu Tyr  Gly Glu Thr Phe Ala  Asn Met Thr 
    1175                 1180                 1185             


Arg Ala  Arg Ser Ala Ser His  Val Cys Val Ala Glu  Ile Glu Val 
    1190                 1195                 1200             


Ala Asp  Thr Ser Ala Val Met  Pro Leu Gly Phe Gln  Ser Pro Phe 
    1205                 1210                 1215             


Met Val  His Pro Ser Thr Leu  Asp Ser Leu Phe His  Pro Leu Phe 
    1220                 1225                 1230             


Val Ala  Leu Ser Ser Asp Glu  Arg Leu Gln Asp Pro  Val Val Pro 
    1235                 1240                 1245             


Val Ala  Ile Glu Glu Ile Thr  Ile Lys His Glu Met  Ala Lys Glu 
    1250                 1255                 1260             


Ala Gly  His Lys Phe Gln Val  Cys Ala Thr Thr Glu  Glu Thr Gly 
    1265                 1270                 1275             


Arg Asp  Arg Ile Leu Ala Ala  Ile Ser Val Val Asp  Ala Gln Arg 
    1280                 1285                 1290             


Ala Arg  Ser Gly Pro Ala Leu  Thr Val Arg Gly Leu  Thr Cys Gln 
    1295                 1300                 1305             


Phe Leu  Asp Arg Ala Ser Gly  Asp Val Glu Gly Ala  Asp Gln Glu 
    1310                 1315                 1320             


Thr Arg  His Ala Tyr Glu Leu  His Trp Glu Ala Asp  Ile Asp Leu 
    1325                 1330                 1335             


Leu Ser  Ser Ser Asp Leu Arg  Thr Leu Cys Ala Val  Gly Arg Pro 
    1340                 1345                 1350             


Arg Asp  Val Gly Glu Lys Val  Ala Ser Tyr Val Lys  Leu Leu Gly 
    1355                 1360                 1365             


His Lys  Phe Pro His Leu Ala  Ile Leu Glu Val Gly  Ala Gly Gln 
    1370                 1375                 1380             


Gly Glu  Leu Cys Ile Ala Val  Phe Arg Ala Leu Ala  Gly Gly Leu 
    1385                 1390                 1395             


Asn Ser  Ile Pro Ser Phe Gln  Ser Tyr Thr Leu Ala  Asp Thr Glu 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Thr Ile  Ala Thr Ile Ala Asp  Gln Phe Asp 
    1415                 1420                 1425             


Gly Arg  Ala Asp Leu Ile Gln  Tyr Lys Glu Leu Asp  Ile Ser Ser 
    1430                 1435                 1440             


Asp Pro  Leu Gln Gln Gly Phe  Thr Ala His Ser Leu  Asp Leu Ile 
    1445                 1450                 1455             


Leu Leu  Pro Ser Arg Gly Val  Ser Ala Thr Leu Arg  Ser Lys Ile 
    1460                 1465                 1470             


Leu Lys  His Ala His Gln Leu  Leu Thr Pro Glu Gly  Met Leu Ile 
    1475                 1480                 1485             


Val Val  Asp Thr Arg Asp Leu  Gln Glu Trp Trp Gln  Ala Leu Arg 
    1490                 1495                 1500             


Glu Ser  Asn Phe Thr Asp Pro  Glu Ile Ala Asn Asp  Ser Gln Ser 
    1505                 1510                 1515             


Glu Val  Gln Ala Asp Ile Ser  Val Leu Val Ser Lys  Pro Gln Pro 
    1520                 1525                 1530             


Gln Arg  Arg Asp Gln Thr Pro  Ser Asp Pro Pro Asp  Val Leu Val 
    1535                 1540                 1545             


Ile Ala  Glu Asn Gln Asp Ser  Gly Val Ser Ile Glu  Gln Leu Gln 
    1550                 1555                 1560             


Arg Asp  Leu Ala Asp Ala His  Val Pro Ala Thr Val  Thr Asp Phe 
    1565                 1570                 1575             


Ala His  Ala Asp Leu Glu Gly  Lys Thr Cys Ile Val  Leu Ser Glu 
    1580                 1585                 1590             


Leu Thr  Thr Ser Leu Leu Ser  His Pro Asp Gln His  Ser Phe Glu 
    1595                 1600                 1605             


Ala Leu  Lys Arg Ile Leu Val  Ala Gly Gly Arg Gly  Val Leu Trp 
    1610                 1615                 1620             


Val Val  Arg Gly Ala Val Gly  Pro Ala Pro Thr Ser  Ser Leu Ala 
    1625                 1630                 1635             


Thr Gly  Leu Leu Arg Thr Ile  Arg Ser Glu Thr Asp  Asp Asp Arg 
    1640                 1645                 1650             


Pro Ile  Ala Ser Leu Asp Leu  Asp Asp Glu His Pro  Leu Ser Pro 
    1655                 1660                 1665             


Glu Ser  Ala Ala Gln Ser Ile  Phe Ser Ala Phe Arg  Asp Arg Phe 
    1670                 1675                 1680             


Val Thr  Pro Gly Gly Ser His  Glu Val Glu Tyr Ala  Glu Arg Asp 
    1685                 1690                 1695             


Gly Gly  Leu Arg Ile Pro Arg  Val Val Glu Ser Ser  Leu Val Asn 
    1700                 1705                 1710             


His Glu  Ile Val Ser Ser Ala  Arg Pro Ala Val Ala  Glu Asp Gln 
    1715                 1720                 1725             


Pro Phe  Phe Gln Thr Gly Gly  Pro Leu Glu Leu Thr  Val Thr Arg 
    1730                 1735                 1740             


Pro Gly  Arg Leu Asp Ser Leu  Tyr Tyr Val Asp Arg  Ser Ser Ile 
    1745                 1750                 1755             


Ser Glu  Leu Pro Ser Asp Tyr  Val Glu Ile Glu Val  Lys Ala Ile 
    1760                 1765                 1770             


Gly Leu  Gly Asn Gly Asp Val  Lys Thr Ala Leu Gly  His Asp Asp 
    1775                 1780                 1785             


Ala Ala  Thr Arg Leu Gly Leu  Glu Cys Ser Gly Val  Val Thr Ala 
    1790                 1795                 1800             


Leu Gly  Asp Ala Val Ser Gly  Phe Lys Ile Gly Asp  Arg Val Ala 
    1805                 1810                 1815             


Gly Phe  Ser Ala Gly Thr Val  Ala Thr Arg Tyr Arg  Asp Gln Ala 
    1820                 1825                 1830             


Asp Phe  Phe Gln Leu Ile Pro  Asp Asp Met Ser Phe  Ala Arg Ala 
    1835                 1840                 1845             


Ala Ala  Leu Pro Val Ala Tyr  Ile Thr Ala Phe Phe  Ala Val His 
    1850                 1855                 1860             


Val Leu  Gly Gln Val Ser Arg  Gly Asp Arg Val Leu  Ile Gln Asp 
    1865                 1870                 1875             


Ala Gly  Thr Ala Ala Gly Gln  Ala Leu Leu Glu Leu  Cys Ala Leu 
    1880                 1885                 1890             


Ala Gly  Gly Asp Ile Ile Ala  Val Val Asp Ser Pro  Ser Gln Arg 
    1895                 1900                 1905             


Ala Phe  Leu Met Gly Glu Tyr  Asp Leu Pro Ala Ser  Arg Ile Leu 
    1910                 1915                 1920             


Val Gly  Leu Arg Gly Arg Arg  Leu Ala Thr Ser Val  Met Thr Lys 
    1925                 1930                 1935             


Thr Arg  Gly Cys Gly Val Asp  Ala Ile Phe Asn Phe  Arg Gly Gly 
    1940                 1945                 1950             


Glu Glu  Arg Arg Leu Cys Trp  Ser Cys Val Ala Pro  Tyr Gly Arg 
    1955                 1960                 1965             


Phe Ile  Asp Leu Gly Gly Gly  Pro Ser Asp Leu Trp  Asp Met Pro 
    1970                 1975                 1980             


Leu Leu  Glu Met Arg Ser Phe  Phe Ser Lys Asn Ala  Ser Phe Thr 
    1985                 1990                 1995             


Ala Leu  Asp Phe His Tyr Leu  Val Thr Gln Lys Pro  Glu Ala Val 
    2000                 2005                 2010             


His Arg  Ile Trp Ser Asp Val  Met Ala Leu Val Arg  Ala Lys Ala 
    2015                 2020                 2025             


Ile Arg  Gly Pro Gly Arg Leu  Gln Leu His Ser Val  Ser Glu Val 
    2030                 2035                 2040             


Gly Thr  Ala Leu Lys Gln Ser  Gln Asp Gly Cys Asp  Val Glu Lys 
    2045                 2050                 2055             


Val Val  Ile Arg Ala Glu Asn  Pro Thr Ile Val Gln  Ala Ala Pro 
    2060                 2065                 2070             


Pro Pro  Gln Gly Asp Leu Leu  Arg Ala Asp Ala Ser  Tyr Val Leu 
    2075                 2080                 2085             


Val Gly  Gly Leu Gly Gly Ile  Gly Arg Ala Met Ala  Ser Trp Met 
    2090                 2095                 2100             


Ile Ala  Asp Gly Ala Arg His  Leu Ile Phe Val Asn  Arg Ser Gly 
    2105                 2110                 2115             


Leu Pro  Arg Asn Pro Ala Arg  Glu Thr Val Glu Ser  Leu Gly Gly 
    2120                 2125                 2130             


His Gly  Ala Gly Val Ala Val  Ala Ser Cys Asp Val  Ser Asp Arg 
    2135                 2140                 2145             


Asp Gln  Val Ala Gln Met Val  Ala Arg Ser Ser Lys  Glu His Pro 
    2150                 2155                 2160             


Pro Ile  Arg Gly Val Ile Gln  Ala Ala Met Ile Leu  Tyr Asp Met 
    2165                 2170                 2175             


Ala Phe  Glu Lys Met Ser Val  Asp Asp Phe Ser Thr  Val Leu Gln 
    2180                 2185                 2190             


Pro Lys  Trp Gln Gly Thr Trp  Asn Leu His Gly Leu  Leu Pro Arg 
    2195                 2200                 2205             


Tyr Met  Asp Phe Phe Ile Met  Leu Ser Ser Ile Ser  Gly Arg Ile 
    2210                 2215                 2220             


Gly Asn  Ala Thr Gln Ala Ala  Tyr Ala Ala Gly Ser  Thr Phe Leu 
    2225                 2230                 2235             


Gly Ala  Phe Ala Gln His Arg  Ser Ser Leu Gly Leu  Pro Ala Val 
    2240                 2245                 2250             


Thr Leu  Asp Leu Gly Val Ile  Asp Gly Ile Gly Tyr  Leu Ser Glu 
    2255                 2260                 2265             


His Thr  Ile Leu Leu Thr Gly  Met Gln Arg Gln Gly  Phe Val Gly 
    2270                 2275                 2280             


Thr Asn  Glu Gln Thr Leu Met  Ala Leu Ile Arg Ser  Ala Ile Val 
    2285                 2290                 2295             


Ser Pro  Arg Arg Thr Gly Ser  Gln Ser Glu Ile Val  Thr Gly Leu 
    2300                 2305                 2310             


Gly Thr  Trp Arg Glu Gly Val  Ser Leu Gly Asn Phe  Ala Gln Pro 
    2315                 2320                 2325             


Leu Phe  Ala His Phe Arg Arg  Gln Ala Glu Gly Leu  Arg Asp Ser 
    2330                 2335                 2340             


Thr Ala  Thr Gly Pro Ile Thr  Ser Val Arg Glu Ser  Leu Arg Asn 
    2345                 2350                 2355             


Cys Met  Thr Arg Asp Asp Ala  Val Ala Leu Val Cys  Ala His Leu 
    2360                 2365                 2370             


Ile Asp  Arg Leu Ala Ala Arg  Leu Asn Thr Pro Val  Asp Asn Ile 
    2375                 2380                 2385             


Asp Ser  Gln Arg Ala Met Ser  Glu Tyr Gly Val Asp  Ser Leu Val 
    2390                 2395                 2400             


Ala Val  Glu Met Arg Asn Trp  Ile Gly Lys Glu Met  Glu Ser Thr 
    2405                 2410                 2415             


Met Pro  Ile Leu Glu Leu Leu  Ala Asn Gln Ser Ile  Ser Gln Leu 
    2420                 2425                 2430             


Ser Glu  Ala Ile Ala Gln Arg  Ser Lys Val Val Ala  Val Ser Gly 
    2435                 2440                 2445             


Ser Glu  Glu 
    2450     


<210>  18
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 14

<400>  18

Met Val Glu Asn Val Ser Ser Pro Ser Ser Pro Arg Thr Pro Ser Pro 
1               5                   10                  15      


Ser Gly Ser Cys Thr Pro Pro Ser Ala Thr Leu Val Thr Ser Asp Asp 
            20                  25                  30          


Lys Ser Met Pro Ile Ala Val Val Gly Met Ser Phe Arg Gly Pro Arg 
        35                  40                  45              


Asp Ala Ile Ser Val Glu Ser Leu Trp Arg Met Ile Ser Glu Gly Arg 
    50                  55                  60                  


Glu Gly Trp Ser Lys Ile Pro Lys Ser Arg Trp Asn Leu Asp Ala Phe 
65                  70                  75                  80  


Tyr His Pro Asp His Ser Arg His Gly Thr Ile Asn Val Glu Gly Gly 
                85                  90                  95      


His Phe Leu Glu Glu Asp Leu Ala Arg Phe Asp Ala Pro Phe Phe Asn 
            100                 105                 110         


Met Thr Asn Ala Glu Ala Ala Ala Leu Asp Pro Gln Gln Arg Leu Leu 
        115                 120                 125             


Leu Glu Ser Thr Phe Glu Ala Val Glu Asn Ala Gly Ile Pro Leu Asp 
    130                 135                 140                 


Lys Met Leu Gly Ser Lys Thr Ser Cys Phe Val Gly Ser Phe Cys Gly 
145                 150                 155                 160 


Asp Tyr Thr Leu Tyr Phe Leu Arg Asp Pro Glu Ala Phe Glu Ser Tyr 
                165                 170                 175     


Gln Gly Thr Asn Ala Gly Gln Ser Leu Ala Ile Thr Ala Asn Arg Val 
            180                 185                 190         


Ser Tyr His Phe Asp Leu Arg Gly Pro Ser Val Thr Val Asp Thr Ala 
        195                 200                 205             


Cys Ser Gly Ser Leu Val Ala Leu His Leu Ala Cys Gln Ser Leu Arg 
    210                 215                 220                 


Thr Gly Asp Ala Lys Met Ala Ile Val Ser Gly Val Asn Thr Ile Leu 
225                 230                 235                 240 


Ser His Tyr Phe Met Ile Thr Met Ser Met Met Arg Phe Leu Ser Pro 
                245                 250                 255     


Asp Gly Arg Cys Tyr Thr Phe Asp Glu Arg Ala Asn Gly Tyr Ala Arg 
            260                 265                 270         


Gly Glu Gly Val Gly Cys Leu Leu Leu Lys Pro Leu Ser Asp Ala Leu 
        275                 280                 285             


Arg Asp Asn Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn 
    290                 295                 300                 


Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu Pro Asn Ala Asn Ala Gln 
305                 310                 315                 320 


Gln Glu Leu Ile Arg Asp Val Tyr Ala Asn Ala Gly Leu Asp Pro Leu 
                325                 330                 335     


Glu Thr Glu Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp 
            340                 345                 350         


Pro Leu Glu Thr Gly Ala Val Ala Lys Val Phe Ser Pro Thr Arg Pro 
        355                 360                 365             


Asp Asp Arg Pro Leu Tyr Ile Gly Ser Ile Lys Thr Asn Val Gly His 
    370                 375                 380                 


Leu Glu Gly Ala Ser Gly Ile Ala Gly Val Ile Lys Ala Val Leu Thr 
385                 390                 395                 400 


Leu Glu Asn Gln Cys Phe Leu Pro Asn Arg Asn Phe Lys Ser Ile Asn 
                405                 410                 415     


Pro Arg Ile Pro Leu Asp Glu Gly Lys Leu Asn Ile Gln Leu Glu Asn 
            420                 425                 430         


Glu Arg Trp Glu Thr Val Gly Pro His Arg Val Ser Val Asn Ser Phe 
        435                 440                 445             


Gly Tyr Gly Gly Ser Asn Ala His Ala Val Leu Glu Asp Thr Lys Gly 
    450                 455                 460                 


Tyr Leu Asp Pro His Ser Leu Thr Gly Ser Phe Asn Arg Val Arg Ala 
465                 470                 475                 480 


Leu Pro His Ala Ala Thr Asp Leu Val Pro Val Ser Asp Pro Gly Ser 
                485                 490                 495     


Gly Pro Glu Arg Thr Arg Leu Phe Val Leu Ser Ser Phe Asp Gln Ala 
            500                 505                 510         


Ser Gly Gln Gln Gln Ile Asp Gln Leu Arg Glu Tyr Leu His Gln Asn 
        515                 520                 525             


Ser Arg Arg Pro Asp Leu Gln Tyr Leu Ala Asp Leu Ala Tyr Thr Leu 
    530                 535                 540                 


Gly Glu Arg Arg Ser Pro Phe Ser Trp Lys Thr Ala Met Pro Ala Thr 
545                 550                 555                 560 


Ser His Ser Ser Leu Val Glu Gln Leu Arg Thr Arg Ala Lys Val Ser 
                565                 570                 575     


Ala Ala Ser Asp Asn Lys Pro Thr Leu Gly Phe Ile Phe Thr Gly Gln 
            580                 585                 590         


Gly Ala Gln Trp Cys Gly Met Gly Arg Glu Leu Leu Ala Ala Tyr Pro 
        595                 600                 605             


Val Phe Ala Ser Ser Val Asp Ala Ile Ala Thr Tyr Leu Lys Ser Leu 
    610                 615                 620                 


Gly Ala Pro Phe Asp Val Val Glu Glu Leu Val Arg Asp Asp Lys Asp 
625                 630                 635                 640 


Ser Lys Ile Asn Gln Pro Val Tyr Ser Gln Pro Ile Cys Thr Ala Val 
                645                 650                 655     


Gln Ile Ala Leu Val Asp Leu Leu Thr Phe Trp Gly Ile Arg Pro Ala 
            660                 665                 670         


Ser Val Thr Gly His Ser Ser Gly Glu Leu Ala Gly Ala Tyr Thr Ala 
        675                 680                 685             


Gly Ala Leu Ser Met Glu His Ser Met Ala Ala Ala Tyr Tyr Arg Gly 
    690                 695                 700                 


Val Ala Ser Glu Asp Leu Ala Arg Val Ser Thr Gln Asp Gly Ala Met 
705                 710                 715                 720 


Met Ala Val Gly Ala Ser Lys Asp Ala Ile Gln Pro Arg Leu Asp Ser 
                725                 730                 735     


Thr Thr Thr Gly Arg Ala Val Val Ala Cys Val Asn Ser Pro Ser Ser 
            740                 745                 750         


Val Thr Ile Ser Gly Asp Ala Ser Ala Val Asp Glu Leu Val Gly Leu 
        755                 760                 765             


Leu Glu Lys Asp Gln Val Phe Ala Arg Lys Leu Ala Val Asp Val Ala 
    770                 775                 780                 


Tyr His Ser His His Met Lys Ala Val Ala Asp Gln Tyr Arg Thr Ala 
785                 790                 795                 800 


Met Ala Ala Ala Gly Val Arg Glu Gln Gln Pro Glu Pro Thr Glu Pro 
                805                 810                 815     


Glu Val Glu Phe Phe Ser Ser Val Thr Gly Glu Lys Ala Ser Leu Thr 
            820                 825                 830         


Val Leu Gly Ile Glu Tyr Trp Val Ala Asn Leu Leu Ser Gln Val Lys 
        835                 840                 845             


Phe Ala Asp Ser Val His Arg Leu Cys Glu Glu Thr Ser Ser Ser Gly 
    850                 855                 860                 


Arg Pro Arg Lys Thr Lys Thr Lys Ala Pro Lys Arg Ser Gly Ala Asn 
865                 870                 875                 880 


Asn Lys Ala Lys Val Asp Met Leu Val Glu Ile Gly Pro His Ser Thr 
                885                 890                 895     


Leu Ala Gly Pro Ile Arg Gln Ile Leu Lys Ala Asp Ser Asn Leu Glu 
            900                 905                 910         


Gln Ala Ala Ile Glu Tyr Ala Ser Ala Leu Leu Arg Lys Lys Ser Ala 
        915                 920                 925             


Val Asp Thr Thr Leu Thr Leu Ala Ser Thr Leu Leu Met Ala Gly Tyr 
    930                 935                 940                 


Pro Ile Asp Met Thr Ala Ile Asn Arg Pro Leu Val His His Arg Val 
945                 950                 955                 960 


Gly Val Leu Val Asp Leu Pro Pro Tyr Pro Trp Asn His Ser Gly Ser 
                965                 970                 975     


Tyr Trp Ala Glu Pro Arg Leu Ser Lys Glu Tyr Arg Asn Arg Glu Arg 
            980                 985                 990         


Pro Arg Asn Asp Leu Leu Gly Val  Leu Asp Thr His Ser  Ser Pro Asp 
        995                 1000                 1005             


Glu Pro  Arg Trp Arg Asn Tyr  Leu Arg Thr Ser Glu  Ile Pro Trp 
    1010                 1015                 1020             


Ile Lys  Asp His Met Ile Gln  Ser Asn Val Val Tyr  Pro Ala Ala 
    1025                 1030                 1035             


Gly Tyr  Leu Thr Met Ala Val  Glu Ala Ile Gly Gln  Arg Ile Ser 
    1040                 1045                 1050             


Pro Asn  Phe Lys Gly His Ala  Ile Cys Gly Glu Arg  Leu Arg Asp 
    1055                 1060                 1065             


Val Ala  Ile Glu Ala Ala Leu  Val Ile Ser Asp Asp  Ser Glu Pro 
    1070                 1075                 1080             


Glu Val  Met Leu Ser Leu Tyr  Pro Ser Gly Asp Ser  Gly Leu Val 
    1085                 1090                 1095             


Asp Ala  Glu Arg Trp Asp Glu  Phe His Val Leu Ser  Val Thr Pro 
    1100                 1105                 1110             


Asp Val  Arg Trp Thr Glu His  Cys Arg Gly Thr Ile  Cys Ala Glu 
    1115                 1120                 1125             


Val Ala  Ala Met Thr Gly Ile  Glu Asp Asp Arg Gly  Ala Glu Ala 
    1130                 1135                 1140             


Gly Leu  Glu Ala Glu Gln Glu  Arg Trp Ile Glu Ala  Ala Glu Glu 
    1145                 1150                 1155             


Leu Cys  Leu Thr Asp Val Asp  Leu Pro Arg Phe Tyr  Ala Glu Leu 
    1160                 1165                 1170             


Thr Ala  Leu Gly Leu Val Tyr  Gly Glu Phe Phe Ala  Asn Met Thr 
    1175                 1180                 1185             


Arg Ala  Arg Ser Ala Ser Asn  Val Cys Leu Ala Glu  Ile Ala Val 
    1190                 1195                 1200             


Ala Asp  Thr Val Ala Val Met  Pro Tyr Gly Tyr Gln  Val Pro Phe 
    1205                 1210                 1215             


Val Val  His Pro Ser Thr Leu  Asp Ser Leu Phe His  Pro Leu Phe 
    1220                 1225                 1230             


Val Ala  Leu Cys Ser Leu Glu  Asn Met Gln Lys Pro  Ala Val Pro 
    1235                 1240                 1245             


Val Ala  Ile Glu Glu Ile Lys  Ile Lys His Gly Met  His Lys Glu 
    1250                 1255                 1260             


Ala Gly  His Lys Phe Gln Val  Phe Ala Ser Thr Gln  Glu Asp Gly 
    1265                 1270                 1275             


Thr Asp  Arg Ile Glu Ala Ala  Ile Ser Val Phe Asp  Ala Gln Arg 
    1280                 1285                 1290             


Thr Thr  Ser Gly Pro Ala Leu  Ser Val Arg Gly Leu  Arg Cys Gln 
    1295                 1300                 1305             


Phe Leu  Asp Arg Ala Ser Val  Asp Glu Glu Gly Ser  Glu Gln Ala 
    1310                 1315                 1320             


Thr Arg  Leu Ala Tyr Glu Leu  His Trp Glu Ala His  Asn Asp Leu 
    1325                 1330                 1335             


Leu Ser  Ser Ser Asp Leu Ala  Thr Leu Cys Ala Val  Gly Arg Pro 
    1340                 1345                 1350             


Arg Asp  Val Met Glu Ala Val  Ala Arg Tyr Val Lys  Leu Leu Gly 
    1355                 1360                 1365             


His Lys  Tyr Pro Ala Leu Ala  Ile Leu Glu Val Gly  Ala Gly Gln 
    1370                 1375                 1380             


Gly Glu  Leu Cys Ile Tyr Val  Phe Arg Ala Leu Ala  Gly Glu Ala 
    1385                 1390                 1395             


Asn Ser  Thr Leu Ser Phe Ala  Ser Tyr Thr Leu Ala  Asp Thr Glu 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Thr Ile  Ala Thr Ile Ala Asp  Lys Phe Ile 
    1415                 1420                 1425             


Glu Arg  Ala Asp Leu Ile Asn  Tyr Lys Glu Leu Asp  Ile Ser Asn 
    1430                 1435                 1440             


Asp Pro  Leu Gln Gln Gly Phe  Asn Asn His Ser Leu  Asp Leu Ile 
    1445                 1450                 1455             


Leu Leu  Pro Ser Arg Gly Val  Ser Ala Thr Leu Arg  Leu Lys Ile 
    1460                 1465                 1470             


Leu Lys  His Ala His Gln Leu  Leu Thr Pro Glu Gly  Arg Leu Ile 
    1475                 1480                 1485             


Val Ile  Asp Leu Arg Asp Leu  Gln Glu Trp Glu Ala  Ala Leu Arg 
    1490                 1495                 1500             


Glu Ser  Asn Phe Thr Asp Pro  Glu Arg Ile His Asp  Leu Val Ala 
    1505                 1510                 1515             


Glu Thr  Ala Ala Ile Thr Ser  Val Leu Val Ser Arg  Pro Gln Pro 
    1520                 1525                 1530             


Glu Pro  Arg Pro Thr Thr Pro  Val Thr Pro Pro Asp  Val Leu Val 
    1535                 1540                 1545             


Ile Ala  Gly Asn Gly Asp Ser  Pro Ala Ser Ile Asn  His Leu Gln 
    1550                 1555                 1560             


Arg Leu  Leu Ala Asp Phe His  Val Pro Ala Thr Leu  Gly Glu Phe 
    1565                 1570                 1575             


Ala Thr  Ser Arg Pro Glu Glu  Ser Thr Cys Ile Val  Leu Ser Glu 
    1580                 1585                 1590             


Leu Thr  Thr Ser Leu Leu Ser  His Pro Asp Gln His  Arg Phe Glu 
    1595                 1600                 1605             


Thr Leu  Lys Arg Ile Leu Val  Ala Ser Gly Arg Gly  Val Leu Trp 
    1610                 1615                 1620             


Val Val  Arg Gly Ala Thr Gly  Pro Ala Pro Thr Ser  Ser Leu Ala 
    1625                 1630                 1635             


Thr Gly  Leu Leu Arg Thr Ile  Arg Ser Glu Thr Asp  Asp Asp Arg 
    1640                 1645                 1650             


Pro Ile  Val Ser Leu Asp Leu  Asp Ala Ser His Ser  Leu Ser Phe 
    1655                 1660                 1665             


Ser Glu  Ala Ala Gln Phe Ile  Gly Ser Ala Phe Arg  Ser Arg Asp 
    1670                 1675                 1680             


Leu Ser  Pro Gly Gly Ser His  Glu Phe Glu Tyr Ala  Glu Arg Asp 
    1685                 1690                 1695             


Gly Ile  Leu Arg Ile Pro Arg  Val Phe Glu Ser Glu  Leu Val Asn 
    1700                 1705                 1710             


His Glu  Ile Val Ser Tyr Asn  Arg Pro Asp Val Ala  Ser Asp Gln 
    1715                 1720                 1725             


Arg Phe  His Gln Pro Gly Asp  Pro Leu Glu Leu Asp  Val Gly Thr 
    1730                 1735                 1740             


Pro Gly  Arg Leu Asp Ser Leu  Tyr Tyr Val Asp Asp  Ser Cys Ile 
    1745                 1750                 1755             


Ser Glu  Leu Pro Ser Asp Tyr  Val Glu Ile Glu Val  Lys Ala Ile 
    1760                 1765                 1770             


Gly Leu  Gly Asn Gly Asp Val  Lys Val Ala Leu Gly  His Asp Asp 
    1775                 1780                 1785             


Ala Ala  Asn Arg Leu Gly Val  Glu Cys Ser Gly Val  Val Thr Ala 
    1790                 1795                 1800             


Leu Gly  Asp Ala Val Ser Gly  Phe Lys Ile Gly Asp  Arg Val Ala 
    1805                 1810                 1815             


Gly Phe  Gly Lys Gly Thr Val  Ala Thr Leu Tyr Arg  Asp Gln Ala 
    1820                 1825                 1830             


Ala Arg  Phe Gln Leu Ile Pro  Asp Asp Met Ser Phe  Ala Arg Ala 
    1835                 1840                 1845             


Ala Ala  Leu Pro Val Ala Tyr  Ile Thr Ala Phe Phe  Ala Val Gln 
    1850                 1855                 1860             


Ala Leu  Gly Gln Val Ser Arg  Gly Asp Arg Val Leu  Ile Gln Asp 
    1865                 1870                 1875             


Ala Gly  Thr Ala Ala Gly Gln  Ala Leu Leu Glu Leu  Cys Ala Tyr 
    1880                 1885                 1890             


Ala Gly  Gly Asp Ile Ile Ala  Val Val Asp Ser Pro  Ser Gln Arg 
    1895                 1900                 1905             


Ala Phe  Leu Val Gly Glu Tyr  Asp Leu Pro Ala Ser  Arg Ile Leu 
    1910                 1915                 1920             


Val Gly  Leu Arg Gly Arg Arg  Leu Ala Thr Thr Val  Met Thr Leu 
    1925                 1930                 1935             


Thr Arg  Gly Cys Gly Val Asp  Ala Ile Phe Asn Phe  Arg Gly Gly 
    1940                 1945                 1950             


Glu Glu  Arg Arg Leu Cys Trp  Ser Cys Val Ala Pro  Tyr Gly Arg 
    1955                 1960                 1965             


Phe Ile  Asp Leu Gly Gly Gly  Pro Ser Asp Leu Glu  Glu Met Asp 
    1970                 1975                 1980             


Thr Leu  Glu Met Ala Ser Phe  Phe Ser Lys Asn Ala  Ser Phe Thr 
    1985                 1990                 1995             


Ala Leu  Asp Phe His Gln Leu  Val Thr Gln Lys Pro  Gln Tyr Val 
    2000                 2005                 2010             


His Arg  Ile Trp Ser Asp Val  Met Arg Leu Val Arg  Ala Lys Val 
    2015                 2020                 2025             


Ile Arg  Gly Pro Pro Arg Leu  Gln Leu His Ser Val  Ser Glu Val 
    2030                 2035                 2040             


Glu Thr  Ala Leu Lys Gln Ser  Gln Asp Gly Cys Asp  Val Glu Lys 
    2045                 2050                 2055             


Val Val  Ile Arg Ala Glu Arg  Ser Thr Val Val Gln  Ala Leu Pro 
    2060                 2065                 2070             


Pro Gln  Lys Gly Asp Lys Leu  Arg Ala Asp Ala Ser  Tyr Val Leu 
    2075                 2080                 2085             


Val Gly  Gly Leu Gly Gly Ile  Gly Arg Ala Met Ala  Ser Trp Met 
    2090                 2095                 2100             


Ile Ala  Asn Gly Ala Arg His  Leu Ile Phe Val Asn  Arg Ser Gly 
    2105                 2110                 2115             


Asn Ala  Arg Asn Glu Ala Arg  Asn Thr Val Glu Ser  Leu Glu Ala 
    2120                 2125                 2130             


His Gly  Ala His Val Thr Phe  Tyr Ser Cys Asp Val  Ser Asp Arg 
    2135                 2140                 2145             


Asp Gln  Val Ser Gln Met Val  Ala Gln Ser Ser Lys  Glu Phe Pro 
    2150                 2155                 2160             


Pro Ile  Arg Gly Val Ile Gln  Ala Ala Met Ile Leu  Arg Asp Met 
    2165                 2170                 2175             


Leu Phe  Asp Lys Met Ser Phe  Asp Asp Phe Asp Thr  Val Leu Gln 
    2180                 2185                 2190             


Pro Lys  Trp Met Gly Thr Trp  Asn Leu His Gly Leu  Leu Pro Arg 
    2195                 2200                 2205             


Asp Met  Asp Ser Phe Ile Met  Leu Ser Ser Ile Ser  Gly His Ile 
    2210                 2215                 2220             


Gly Asn  Ala Thr Gln Ala Ala  Tyr Ala Ala Gly Ser  Thr Phe Leu 
    2225                 2230                 2235             


Gly Ala  Phe Ala Gln Tyr Arg  Ser Ser Asp Gly Leu  Pro Ala Val 
    2240                 2245                 2250             


Thr Leu  Asp Leu Gly Val Ile  Thr Gly Ile Gly Tyr  Leu Ser Glu 
    2255                 2260                 2265             


His Glu  Glu Leu Lys Gln Gly  Met Glu Arg Gln Gly  Phe Pro Gly 
    2270                 2275                 2280             


Thr Asn  Glu Gln Thr Leu Met  Ala Leu Ile Leu Val  Ala Ile Val 
    2285                 2290                 2295             


Ser Pro  Arg Arg Thr Phe Ser  Gln Leu Glu Ile Val  Thr Gly Leu 
    2300                 2305                 2310             


Asp Thr  Trp Asp Glu Gly Gly  Pro Leu Gly Ile Phe  Asp Gln Pro 
    2315                 2320                 2325             


Leu Phe  Ala His Phe Arg Arg  Pro Ala Arg Pro Leu  Arg Asp Arg 
    2330                 2335                 2340             


Thr Ala  Glu Gly Pro Gly Thr  Ser Val Ala Glu Ser  Leu Arg Gly 
    2345                 2350                 2355             


Cys Glu  Thr Leu Asp Asp Ala  Val Ala Leu Val Cys  Ala Trp Leu 
    2360                 2365                 2370             


Ile Asp  Arg Leu Ala Ser Arg  Leu Asn Thr Pro Val  Asp Asn Ile 
    2375                 2380                 2385             


Asp Ser  Gln Arg Ala Met Ser  Glu Tyr Gly Val Asp  Ser Leu Val 
    2390                 2395                 2400             


Ala Val  Glu Met Arg Asn Trp  Ile Gly Lys Glu Met  Glu Ser Thr 
    2405                 2410                 2415             


Met Pro  Ile Leu Glu Leu Leu  Ala Asn Gln Ser Ile  Ser Gln Leu 
    2420                 2425                 2430             


Ser Glu  Lys Ile Ala Gln Arg  Ser Lys Val Val Ala  Val Ser Gly 
    2435                 2440                 2445             


Ser Glu  Glu 
    2450     


<210>  19
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 14

<400>  19

Met Val Glu Asn Val Ser Ser Pro Ser Ser Pro Arg Thr Ser Ser Pro 
1               5                   10                  15      


Ser Thr Ser Cys Asn Pro Thr Ser Ala Thr Ser Val Gly Ala Asp Asp 
            20                  25                  30          


Lys Ser Met Pro Ile Ala Val Val Gly Met Ser Phe Arg Gly Pro Arg 
        35                  40                  45              


Asp Ala Arg Ser Val Glu Ser Leu Trp Arg Met Ile Ser Glu Gly Arg 
    50                  55                  60                  


Glu Gly Trp Ser Lys Ile Pro Pro Ser Arg Trp Asn Asn Asp Ala Phe 
65                  70                  75                  80  


Tyr His Pro Asp His Glu Arg Pro Gly Thr Ile Thr Val Glu Gln Gly 
                85                  90                  95      


His Phe Leu Pro Glu Asp Leu Ala Asp Phe Asp Ala Glu Phe Phe Asn 
            100                 105                 110         


Met Thr Asn Ala Glu Ala Arg Ala Leu Asp Pro Gln Gln Arg Leu Leu 
        115                 120                 125             


Leu Glu Ser Thr Phe Glu Ala Val Glu Asn Ala Gly Ile Pro Leu Arg 
    130                 135                 140                 


Ser Met Pro Gly Ser Lys Thr Ser Cys Phe Val Gly Ser Phe Cys Tyr 
145                 150                 155                 160 


Asp Tyr Thr Asp Met Leu Ser Arg Asp Pro Glu Ala Ile Pro Glu Tyr 
                165                 170                 175     


Gln Cys Thr Asn Ala Gly Gln Ser Arg Ala Ile Thr Ala Asn Arg Val 
            180                 185                 190         


Ser Tyr Glu Phe Asp Leu Arg Gly Pro Ser Val Thr Val Asp Thr Ala 
        195                 200                 205             


Cys Ser Gly Ser Leu Val Ala Leu His Leu Ala Cys Gln Ser Leu Arg 
    210                 215                 220                 


Thr Gly Asp Ala Lys Met Ala Ile Val Ser Gly Val Asn Thr Ile Leu 
225                 230                 235                 240 


Ser His Glu Phe Met Ser Gly Met Ser Met Met Arg Phe Leu Ser Pro 
                245                 250                 255     


Asp Gly Arg Cys Tyr Thr Phe Asp Glu Arg Ala Asn Gly Tyr Ala Arg 
            260                 265                 270         


Gly Glu Gly Val Gly Cys Leu Leu Leu Lys Pro Leu Ser Asp Ala Leu 
        275                 280                 285             


Arg Asp Asn Asp Thr Ile Arg Ala Val Ile Arg Gly Thr Gly Ser Asn 
    290                 295                 300                 


Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu Pro Asn Ala Asn Ala Gln 
305                 310                 315                 320 


Gln Glu Leu Ile Arg Asp Val Tyr Ala Ala Ala Gly Leu Asp Pro Leu 
                325                 330                 335     


Glu Thr Glu Tyr Val Glu Cys His Gly Thr Gly Thr Gln Ala Gly Asp 
            340                 345                 350         


Pro Leu Glu Thr Gly Ala Val Arg Lys Val Phe Ser Arg Gly Arg Pro 
        355                 360                 365             


Asp Asp Arg Pro Leu Thr Ile Gly Ser Ile Lys Thr Asn Val Gly His 
    370                 375                 380                 


Leu Glu Gly Ala Ser Gly Ile Ala Gly Val Ile Lys Ala Val Leu Thr 
385                 390                 395                 400 


Leu Glu Asn Gln Cys Phe Leu Pro Asn Arg Asn Phe Lys Ser Ile Asn 
                405                 410                 415     


Pro Arg Ile Pro Leu Lys Ala Trp Lys Leu Lys Ile Gln Leu Glu Leu 
            420                 425                 430         


Glu Arg Trp Glu Thr Val Gly Pro His Arg Val Ser Val Asn Ser Phe 
        435                 440                 445             


Gly Tyr Gly Gly Ser Asn Ala His Ala Val Leu Glu Asp Thr Lys Gly 
    450                 455                 460                 


Val Glu Glu Gln Arg Ser Leu Asn Gly Ser Phe Glu Arg Val Arg Ala 
465                 470                 475                 480 


Leu Pro Ala His Ala Thr Asp Ser Thr Pro Val Ser Asp Pro Gly Ser 
                485                 490                 495     


Gly Pro Glu Arg Thr Arg Leu Phe Val Leu Ser Ser Phe Asp Gln Ala 
            500                 505                 510         


Ser Gly Gln Gln Gln Ile Asp Gln Leu Arg Glu Tyr Leu Glu Gln Val 
        515                 520                 525             


Ser Ser Arg Asp Asp Asp Leu Tyr Leu Ala Asp Leu Ala Tyr Thr Leu 
    530                 535                 540                 


Gly Glu Arg Arg Ser Pro Phe Leu Trp Lys Thr Ala Met Pro Ala Ser 
545                 550                 555                 560 


Ser Val Ser Ser Leu Lys Glu Gly Leu Arg Thr Arg Val Val Val Ser 
                565                 570                 575     


Gln Gly Glu Glu Lys Lys Pro Thr Leu Gly Phe Ile Phe Thr Gly Gln 
            580                 585                 590         


Gly Ala Gln Trp Cys Gly Met Gly Arg Glu Leu Leu Ala Ala Tyr Pro 
        595                 600                 605             


Val Phe Ala Ser Ser Val Asp Ala Ile Ala Thr Tyr Leu Arg Ser Leu 
    610                 615                 620                 


Gly Ala Pro Phe Asp Val Arg Glu Glu Leu Val Arg Asp Pro Lys Asp 
625                 630                 635                 640 


Ser Pro Ile Asn Gln Pro Leu Tyr Ser Gln Pro Ile Cys Thr Ala Val 
                645                 650                 655     


Gln Ile Ala Leu Val Asp Leu Leu Thr Phe Trp Gly Ile Arg Pro Ala 
            660                 665                 670         


Ser Val Thr Gly His Ser Ser Gly Glu Leu Ala Gly Ala Tyr Thr Ala 
        675                 680                 685             


Gly Ala Leu Ser Met Glu His Ser Met Ala Ala Ala Tyr Tyr Arg Gly 
    690                 695                 700                 


Val Ala Ser Ala Asp Leu Pro Arg Glu Arg Thr Gln Arg Gly Ala Met 
705                 710                 715                 720 


Met Ala Val Gly Ala Ser Lys Asp Ala Ile Gln Pro Arg Leu Ser Ser 
                725                 730                 735     


Trp Thr Ser Gly Glu Ala Val Val Ala Cys Val Asn Ser Pro Ser Ser 
            740                 745                 750         


Val Thr Ile Ser Gly Asp Ala Ser Ala Val Asp Glu Leu His Gly Leu 
        755                 760                 765             


Leu Glu Lys Asp Gln Val Phe Ala Arg Lys Leu Ala Val Asp Val Ala 
    770                 775                 780                 


Tyr His Ser His His Met Lys Ala Val Ala Asp Gln Tyr Arg Thr Ala 
785                 790                 795                 800 


Met Ala Ala Ala Gly Val Thr Ala Val Ser Pro Glu Ser Thr Glu Pro 
                805                 810                 815     


Glu Val Glu Phe Phe Ser Ser Val Thr Gly Glu Lys Ala Ser Glu Thr 
            820                 825                 830         


Asp Leu Gly Ile Glu Tyr Trp Val Ala Asn Leu Leu Ser Gln Val Lys 
        835                 840                 845             


Phe Ala Asp Ser Val His Arg Leu His Glu Gly Tyr Lys Asp Lys Gly 
    850                 855                 860                 


Arg Lys Arg Lys Thr Lys Thr Lys Ala Pro Lys Arg Ser Gly Ala Arg 
865                 870                 875                 880 


Asn Lys Asn Lys Val Asp Met Leu Val Glu Ile Gly Pro His Ser Thr 
                885                 890                 895     


Leu Ala Gly Pro Ile Arg Gln Ile Leu Gly Asp Asp Thr Thr Leu Glu 
            900                 905                 910         


Gln Ala Ser Ile Arg Tyr Ala Ser Ala Leu Leu Arg Lys Ser Ser Ala 
        915                 920                 925             


Val Ala Thr Thr Leu Thr Leu Ala Ser Thr Leu Leu Met Ala Gly Tyr 
    930                 935                 940                 


Pro Ile Asp Met Ala Ala Ile Asp Arg Pro Ser Asp Pro Pro Lys Leu 
945                 950                 955                 960 


Ser Val Leu Val Asp Leu Pro Pro Tyr Pro Trp Asn His Ser Gly Ser 
                965                 970                 975     


Tyr Trp Ala Glu Pro Arg Leu Ser Leu Ala Tyr Arg Asn Arg Ala Lys 
            980                 985                 990         


Pro Arg Asn Asp Leu Leu Gly Val  Leu Asp Thr Glu Ser  Ser Pro Arg 
        995                 1000                 1005             


Glu Pro  Arg Trp Arg Asn Tyr  Leu Arg Thr Ser Glu  Glu Pro Trp 
    1010                 1015                 1020             


Ile Lys  Asp His Met Ile Gln  Ser Ser Val Val Tyr  Pro Ala Ala 
    1025                 1030                 1035             


Gly Tyr  Leu Thr Met Ala Val  Glu Ala Ile Gly Gln  Arg Ile Ser 
    1040                 1045                 1050             


Glu Asn  Asp Ala Gly Phe Leu  Ile Ser Pro Tyr Arg  Leu Arg Asp 
    1055                 1060                 1065             


Val Ala  Ile Glu Ala Ala Leu  Val Ile Ser Asp Asp  Ser Glu Pro 
    1070                 1075                 1080             


Glu Val  Met Leu Ser Leu Arg  Pro Ser Arg Asp Ala  Gly Leu Val 
    1085                 1090                 1095             


Ser Asp  Glu Arg Trp His Glu  Phe His Val Leu Ser  Val Thr Gly 
    1100                 1105                 1110             


Asp Asp  Arg Trp Thr Glu His  Cys Arg Gly Leu Ile  Cys Ala Thr 
    1115                 1120                 1125             


Val Ala  Ala Met Asp Ser Asp  Glu Ala Asp Ala Gly  Ala Glu Ala 
    1130                 1135                 1140             


Gly His  Thr Ala Glu Glu Glu  Arg Trp Ile Glu Glu  Ala Phe Gln 
    1145                 1150                 1155             


Leu Cys  Gln Lys Asp Val Asp  Ile Pro Arg Phe Tyr  Ala Glu Leu 
    1160                 1165                 1170             


Thr Gly  Leu Gly Leu Gln Tyr  Gly Glu Ser Phe Ala  Asn Met Thr 
    1175                 1180                 1185             


Arg Ala  Arg Ser Ala Ser His  Val Cys Leu Ala Glu  Ile Thr Val 
    1190                 1195                 1200             


Ala Asp  Thr Glu Thr Val Met  Pro Leu Gly Phe Glu  Ser Gly Phe 
    1205                 1210                 1215             


Val Val  His Pro Ser Thr Leu  Asp Ser Leu Phe His  Pro Leu Phe 
    1220                 1225                 1230             


Val Ala  Leu Ser Ser Asp Gln  Ser Gly Gln Asp Pro  Phe Val Pro 
    1235                 1240                 1245             


Val Ala  Ile Glu Glu Ile Tyr  Ile Arg His Asn Met  Ala Glu Glu 
    1250                 1255                 1260             


Gly Gly  His Lys Phe Gln Val  Cys Ala Ser Thr Ser  Glu Ser Gly 
    1265                 1270                 1275             


Asp Asp  Arg Val Gln Ala Ala  Ile Ser Val Met Asp  Phe Gln Arg 
    1280                 1285                 1290             


Ala Ser  Ser Gly Pro Ala Leu  Thr Val Arg Gly Leu  Thr Cys Gln 
    1295                 1300                 1305             


Phe Leu  Asp Arg Ala Ser Gly  Asp Pro Glu Gly Asp  Glu Ala Val 
    1310                 1315                 1320             


Ser Arg  Leu Ala Tyr Arg Leu  Ile Trp Thr Ala Asp  Val Asp Leu 
    1325                 1330                 1335             


Gly Ser  Ser Ser Asp Leu Ala  Thr Leu Cys Ala Val  Gly Arg Pro 
    1340                 1345                 1350             


Arg Asp  Val Gly Glu Ile Val  Ala Ala Tyr Val Lys  Leu Leu Gly 
    1355                 1360                 1365             


His Lys  Asn Pro His Leu Ala  Ile Leu Glu Val Gly  Ala Gly Gln 
    1370                 1375                 1380             


Gly Glu  Leu Cys Lys Pro Val  Phe Arg Arg Leu Thr  Gly Glu Ala 
    1385                 1390                 1395             


Asn Ser  Thr Arg Ser Phe Gln  Ser Tyr Thr Leu Ala  Asp Thr Glu 
    1400                 1405                 1410             


Pro Gly  Leu Ser Glu Thr Ile  Ala Thr Ile Ala Asp  Lys Phe Asp 
    1415                 1420                 1425             


Asp Arg  Ala Arg Arg Ile Glu  Tyr Lys Glu Leu Asp  Ile Ser His 
    1430                 1435                 1440             


Asp Pro  Leu Gln Gln Gly Phe  Asn Ala His Ser Leu  Asp Leu Ile 
    1445                 1450                 1455             


Leu Leu  Pro Gly Arg Gly Val  Ser Ala Thr Leu Arg  Ser Gln Ile 
    1460                 1465                 1470             


Leu Lys  His Ala His Gln Leu  Leu Thr Pro Glu Gly  Arg Leu Ile 
    1475                 1480                 1485             


Val Gly  Asp Thr Arg Asp Leu  Gln Asp Trp Asp Gln  Ala Leu Leu 
    1490                 1495                 1500             


Glu Ser  Asn Phe Thr Asp Pro  Glu Val Ile His Asp  Ser Asp Gly 
    1505                 1510                 1515             


Glu Thr  Ala Ala Ala Ile Ser  Val Leu Val Ser Lys  Pro Gln Pro 
    1520                 1525                 1530             


Gln Pro  Arg Ala Gln Thr Pro  His Gly Asp Pro Asp  Ile Leu Val 
    1535                 1540                 1545             


Ile Ala  Ile Asn Gln Thr Ser  Gly Gly Arg Ile Glu  Gly Leu Gln 
    1550                 1555                 1560             


Arg Leu  Leu Ala Asp Ala His  Ile Val Ala His Val  Thr Arg Phe 
    1565                 1570                 1575             


Ala His  Ala Leu Pro Glu Gly  Lys Thr Cys Ile Val  Leu Ser Glu 
    1580                 1585                 1590             


Leu Thr  Gln Ser Leu Leu Ser  His Pro Asp Gln His  Ser Phe His 
    1595                 1600                 1605             


Ala Leu  Lys Ser Ile Leu Val  Ala Gly Gly Lys Ser  Val Leu Trp 
    1610                 1615                 1620             


Val Val  Arg Gly Ala Thr Gly  Pro Ala Pro Thr Ala  Ser Leu Ala 
    1625                 1630                 1635             


Thr Gly  Leu Leu Arg Thr Ile  Arg Ser Glu Thr Asp  Asp Asp Arg 
    1640                 1645                 1650             


Pro Ile  Val Ser Leu Asp Leu  Asp Ala Ser His Asn  Leu Ser Ala 
    1655                 1660                 1665             


Glu Gln  Ala Ala Gln Leu Ile  Lys Ser Ala Phe Arg  His Arg Gly 
    1670                 1675                 1680             


Val Glu  Ser Gly Ser Ser Glu  Glu Val Glu Tyr Ala  Glu Arg Asp 
    1685                 1690                 1695             


Gly Ile  Leu Arg Ile Pro Arg  Val Val Glu Leu Ser  Leu Val Asn 
    1700                 1705                 1710             


His Val  Ile Val Ser Ser Leu  Arg Leu Ala Pro Ala  Glu Asp Gln 
    1715                 1720                 1725             


Pro Leu  Leu Gln Pro Gly Arg  Pro Leu Glu Leu Thr  Val Gly Thr 
    1730                 1735                 1740             


Pro Gly  Met Leu Asp Ser Leu  Ala Tyr Val Asp Asp  Ser Cys Ile 
    1745                 1750                 1755             


Ser Glu  Leu Pro Ser Asp Tyr  Val Glu Ile Glu Val  Lys Ala Ile 
    1760                 1765                 1770             


Gly Leu  Gly Asn Gly Asp Val  Lys Thr Ala Leu Gly  His Asp Asp 
    1775                 1780                 1785             


Ala Ala  Thr Trp Leu Gly Ala  Glu Cys Ser Gly Val  Val Thr Ala 
    1790                 1795                 1800             


Leu Gly  Asp Ala Val Ser Gly  Phe Lys Ile Gly Asp  Arg Val Ala 
    1805                 1810                 1815             


Gly Phe  Val Ser Gly Thr Val  Ala Thr Leu Tyr Arg  Asp Gln Ala 
    1820                 1825                 1830             


Asp Arg  Phe Gln Leu Ile Pro  Asp Asp Met Ser Phe  Ala Arg Ala 
    1835                 1840                 1845             


Ala Ala  Leu Pro Val Ala Tyr  Ile Thr Ala Phe Phe  Ala Val His 
    1850                 1855                 1860             


Ala Leu  Gly Gln Val Ser Arg  Gly Asp Arg Val Leu  Ile Gln Asp 
    1865                 1870                 1875             


Ala Gly  Thr Ala Ala Gly Gln  Ala Leu Leu Glu Leu  Cys Ala Leu 
    1880                 1885                 1890             


Ala Gly  Gly Asp Ile Ile Ala  Val Val Asp Ser Pro  Ser Gln Arg 
    1895                 1900                 1905             


Ala Phe  Leu Arg Gly Glu Tyr  Asp Leu Pro Ala Ser  Arg Ile Leu 
    1910                 1915                 1920             


Val Gly  Leu Arg Gly Arg Arg  Leu Ala Thr Gln Val  Met Thr Leu 
    1925                 1930                 1935             


Thr Arg  Gly Cys Gly Val Asp  Ala Ile Phe Asn Phe  Arg Gly Gly 
    1940                 1945                 1950             


Glu Glu  Arg Arg Leu Cys Trp  Ser Cys Val Ala Pro  Tyr Gly Arg 
    1955                 1960                 1965             


Phe Ile  Asp Leu Gly Gly Gly  Pro Ser Asp Leu Thr  Ser Met Pro 
    1970                 1975                 1980             


Gln Leu  Glu Met Gly Ser Phe  Phe Glu Lys Asn Ala  Ser Phe Thr 
    1985                 1990                 1995             


Ala Leu  Asp Phe His Leu Leu  Val Thr Gln Lys Pro  Asp Ala Val 
    2000                 2005                 2010             


His Arg  Ile Trp Ser Asp Val  Glu Gln Leu Val Ala  Ala Lys Ala 
    2015                 2020                 2025             


Ile Arg  Gly Pro Pro Arg Leu  Gln Leu His Ser Val  Ser Glu Val 
    2030                 2035                 2040             


Glu Thr  Ala Leu Lys Phe Ser  Gln Asp Gly Cys Asp  Val Glu Lys 
    2045                 2050                 2055             


Val Val  Ile Arg Ala Glu Arg  Asp Thr Ile Val Arg  Ala Leu Pro 
    2060                 2065                 2070             


Arg Pro  Lys Gly Val Leu Leu  Arg Ala Asp Ala Ser  Tyr Val Leu 
    2075                 2080                 2085             


Val Gly  Gly Leu Gly Gly Ile  Gly Arg Ala Met Ala  Ser Lys Met 
    2090                 2095                 2100             


Ile Ala  Asn Gly Ala Arg His  Leu Ile Phe Val Asn  Arg Ser Gly 
    2105                 2110                 2115             


Leu Ala  His Asn Gly Ala Arg  Glu Thr Val Glu Ser  Leu Glu Gly 
    2120                 2125                 2130             


Ala Gly  Ala Asp Val Ala Leu  Tyr Ser Cys Asp Val  Ser Asp Arg 
    2135                 2140                 2145             


Asp Gln  Val Ala Gln Met Val  Ala Gln Ser Ser Lys  Gly Met Pro 
    2150                 2155                 2160             


Pro Ile  Arg Gly Val Ile Gln  Ala Ala Met Ile Leu  Arg Asp Met 
    2165                 2170                 2175             


Leu Phe  Glu Lys Met Ser Val  Asp Asp Phe Asn Thr  Val Leu Gln 
    2180                 2185                 2190             


Pro Lys  Trp Ala Gly Thr Trp  Asn Leu His Gly Leu  Leu Pro Arg 
    2195                 2200                 2205             


Asp Met  Asp Phe Phe Ile Met  Leu Ser Ser Ile Ser  Gly Val Tyr 
    2210                 2215                 2220             


Gly Gly  Ala Thr Gln Ala Ala  Tyr Ala Ala Gly Ser  Thr Phe Leu 
    2225                 2230                 2235             


Gly Ala  Phe Ala Gln Tyr Arg  Ser Ser Ala Gly Leu  Pro Ala Val 
    2240                 2245                 2250             


Thr Leu  Asp Leu Gly Val Ile  Thr Gly Ile Gly Tyr  Leu Ser Glu 
    2255                 2260                 2265             


Ala Gly  Glu Leu Ser Gln Gly  Met Gln Arg Thr Gly  Ala Asn Ser 
    2270                 2275                 2280             


Thr Asn  Glu Gln Thr Leu Met  Ala Leu Ile Arg Gln  Ala Ile Val 
    2285                 2290                 2295             


Arg Pro  Arg Arg Thr Gly Phe  Gln Ala Glu Ile Val  Thr Gly Leu 
    2300                 2305                 2310             


Gly Thr  Trp Arg Pro Val Thr  Ser Leu Gly Gly Ser  Met Gln Pro 
    2315                 2320                 2325             


Leu Phe  Ala Gly Phe Tyr Arg  Glu Gln Leu Ile Gln  Arg Asp Ser 
    2330                 2335                 2340             


Thr Ala  Glu Gly Pro Gly Thr  Ser Val Arg Glu Ser  Leu Arg Gly 
    2345                 2350                 2355             


Cys Ser  Thr Leu Asp Asp Ala  Val Ala Leu Val Thr  Ala Ala Leu 
    2360                 2365                 2370             


Ile Asp  Arg Leu Ala Ser Arg  Leu Asn Thr Pro Val  Asp Asn Ile 
    2375                 2380                 2385             


Asp Ser  Gln Arg Ala Met Ser  Glu Tyr Gly Val Asp  Ser Leu Val 
    2390                 2395                 2400             


Ala Val  Glu Met Arg Asn Trp  Ile Gly Lys Glu Met  Glu Ser Thr 
    2405                 2410                 2415             


Met Pro  Ile Leu Glu Leu Leu  Ala Pro Gln Ser Ile  Ser Gln Leu 
    2420                 2425                 2430             


Ser Glu  Lys Ile Ala Gln Arg  Ser Lys Val Val Asn  Val Ser Gly 
    2435                 2440                 2445             


Ser Glu  Glu 
    2450     


<210>  20
<211>  730
<212>  DNA
<213>  Talaromyces stipitatus

<400>  20
atgcgtctat caactctctc ctctctcctt ctaggaagca gcagtattgt ctttgcacga       60

gtcccaccta ccgtcgataa ccaagagccc atcaaatcga catcctactt cctcgacgat      120

cccgacttcc cttcccactt cgaattcgag aatcccgaga caaactgcaa atacgtctcg      180

cagccatgga tctacaatgc cttcaacagc gtcagcgagg atatggaagc tgtcttcaaa      240

tacgctcatc ctgacttgca tgttagaatc atgggccatc atccgtttgc tggatactac      300

cacaatccta agatggcatt tgtcaactcg ctttggcggt tgaataattg cttgaaggat      360

gccaaggtcg atgcaaaact ttgggctatt cacggtggat gtgatcaggc gtggagcgtg      420

caagaattct acttcaatgc gactaccaac aaaggtgagg aaaccatctt tcacttttat      480

tggaagagca atgctgacaa ggacaggaca accatgggaa ttgacgagtc tctgggtctc      540

ccgctgggac gaggatggac tcattagaga agtccgcacc tgggtcgatg ctggccaaat      600

catgcgtact ctctgggata atgaaatttg gttcaactcg agcgaccgcg tccatcacta      660

cgatttcatt cccggtcctg gtggccttcc gcctattgct aataaaactg aattaggggg      720

tgaactataa                                                             730


<210>  21
<211>  225
<212>  PRT
<213>  Talaromyces stipitatus

<400>  21

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Leu Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Lys Tyr Val Ser Gln Pro Trp Ile 
    50                  55                  60                  


Tyr Asn Ala Phe Asn Ser Val Ser Glu Asp Met Glu Ala Val Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Ile Met Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Phe Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Leu Asn Asn Cys Leu Lys Asp Ala Lys Val Asp Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Asp Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Ala Thr Thr Asn Lys Gly Gln Pro Trp Glu Leu Thr Ser Leu 
145                 150                 155                 160 


Trp Val Ser Arg Trp Asp Glu Asp Gly Leu Ile Arg Glu Val Arg Thr 
                165                 170                 175     


Trp Val Asp Ala Gly Gln Ile Met Arg Thr Leu Trp Asp Asn Glu Ile 
            180                 185                 190         


Trp Phe Asn Ser Ser Asp Arg Val His His Tyr Asp Phe Ile Pro Gly 
        195                 200                 205             


Pro Gly Gly Leu Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  22
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  22

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Leu Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Lys Tyr Val Ser Gln Pro Trp Ile 
    50                  55                  60                  


Tyr Asn Ala Phe Asn Ser Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Ile Met Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Phe Val Asn Thr Leu Trp 
            100                 105                 110         


Arg Leu Asn Asn Cys Leu Lys Asp Ala Lys Val Asp Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Asp Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Ala Thr Thr Asn Lys Gly Gln Pro Trp Glu Leu Thr Ser Leu 
145                 150                 155                 160 


Trp Val Thr Arg Trp Asp Glu Glu Gly Leu Met Arg Glu Val Arg Thr 
                165                 170                 175     


Trp Ile Asp Ala Ala Gln Ile Met Arg Thr Leu Trp Glu Asn Glu Leu 
            180                 185                 190         


Trp Trp Asn Ser Thr Asp Arg Val His His Tyr Glu Phe Ile Pro Gly 
        195                 200                 205             


Pro Gly Gly Leu Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  23
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  23

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Val Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Lys Tyr Val Ser Gln Pro Trp Ile 
    50                  55                  60                  


Tyr Asn Ala Phe Asn Ser Val Ser Glu Asp Met Glu Ala Val Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Ile Met Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Phe Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Leu Asn Asn Cys Leu Lys Glu Ala Lys Val Asp Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Asp Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Gln Gly Thr Thr Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Leu 
145                 150                 155                 160 


Trp Val Thr Arg Trp Asp Glu Asp Gly Leu Ile Arg Glu Val Arg Thr 
                165                 170                 175     


Trp Val Asp Ala Ala Gln Ile Met Arg Thr Leu Trp Glu Asn Glu Ile 
            180                 185                 190         


Trp Trp Asn Ser Ser Asp Arg Val His His Tyr Asp Tyr Ile Pro Gly 
        195                 200                 205             


Pro Gly Ala Leu Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  24
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  24

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Ile Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Arg Tyr Val Ser Gln Pro Trp Ile 
    50                  55                  60                  


Tyr Asn Ala Phe Asn Ser Val Ser Glu Asp Met Glu Ala Val Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Val Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Tyr Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Val Asn Asn Cys Leu Lys Asp Ala Lys Val Glu Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Asp Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Ala Thr Thr Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Leu 
145                 150                 155                 160 


Trp Val Thr Lys Trp Asp Asp Asp Gly Leu Met Arg Glu Val Arg Thr 
                165                 170                 175     


Trp Val Asp Ala Gly Gln Ile Met Arg Thr Leu Trp Asp Asn Glu Leu 
            180                 185                 190         


Trp Trp Asn Ser Ser Asp Arg Val His His Tyr Asp Phe Ile Pro Gly 
        195                 200                 205             


Pro Gly Gly Met Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  25
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  25

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Leu Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Lys Tyr Val Ser Gln Pro Trp Ile 
    50                  55                  60                  


Trp Asn Ala Phe Asn Ser Val Ser Glu Asp Met Glu Ala Val Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Ile Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Tyr Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Val Asn Asn Cys Leu Lys Glu Ala Lys Val Asp Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Asp Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Gly Thr Thr Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Val 
145                 150                 155                 160 


Trp Val Thr Arg Trp Asp Glu Glu Gly Leu Ile Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Val Asp Ala Gly Gln Ile Met Arg Thr Ile Trp Glu Asn Glu Ile 
            180                 185                 190         


Trp Trp Asn Ser Ser Asp Arg Val His His Tyr Asp Phe Ile Pro Gly 
        195                 200                 205             


Pro Gly Gly Met Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  26
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  26

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Ile Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Lys Tyr Val Ser Gln Pro Trp Ile 
    50                  55                  60                  


Tyr Asn Ala Phe Asn Thr Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Ile Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Tyr Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Leu Asn Asn Cys Leu Lys Glu Ala Lys Val Asp Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Glu Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Ala Thr Thr Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Val 
145                 150                 155                 160 


Trp Ile Thr Arg Phe Glu Glu Asp Gly Leu Val Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Val Asp Ala Gly Gln Val Met Lys Thr Leu Trp Asp Asn Glu Leu 
            180                 185                 190         


Trp Trp Asn Ser Thr Asp Arg Val His His Tyr Asp Trp Ile Pro Gly 
        195                 200                 205             


Pro Ala Gly Leu Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  27
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  27

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Leu Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Asp Asn Pro Glu Thr Asn Cys Lys Tyr Val Ser Gln Pro Tyr Ile 
    50                  55                  60                  


Trp Asn Ala Phe Asn Thr Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Val Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Phe Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Leu Asn Asn Cys Leu Lys Asp Ala Lys Val Asp Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Glu Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Ala Thr Thr Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Val 
145                 150                 155                 160 


Trp Val Ser Arg Trp Glu Glu Glu Gly Leu Met Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Val Asp Ala Ala Gln Val Met Lys Thr Ile Trp Glu Asn Glu Ile 
            180                 185                 190         


Trp Trp Asn Ser Ser Asp Arg Val His His Tyr Asp Tyr Ile Pro Gly 
        195                 200                 205             


Pro Gly Gly Met Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  28
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  28

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Val Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Lys Phe Val Thr Gln Pro Trp Ile 
    50                  55                  60                  


Trp Asn Ala Phe Asn Thr Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Ile Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Tyr Val Asn Thr Leu Trp 
            100                 105                 110         


Arg Val Asn Asn Cys Leu Lys Glu Ala Lys Val Glu Ala Lys Leu Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Asp Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Gly Thr Thr Asn Lys Gly Gln Pro Trp Glu Ile Thr Ser Val 
145                 150                 155                 160 


Trp Ile Thr Arg Phe Asp Asp Glu Gly Leu Met Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Ile Asp Ala Ala Gln Val Met Lys Thr Ile Trp Glu Asn Glu Ile 
            180                 185                 190         


Trp Trp Asn Ser Thr Asp Arg Val His His Tyr Asp Tyr Ile Pro Gly 
        195                 200                 205             


Pro Ala Ala Met Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  29
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  29

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Ile Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Asp Asn Pro Glu Thr Asn Cys Arg Phe Val Ser Gln Pro Tyr Ile 
    50                  55                  60                  


Tyr Asn Ala Phe Asn Ser Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Val Met Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Phe Val Asn Ser Leu Trp 
            100                 105                 110         


Arg Val Asn Asn Cys Leu Lys Glu Gly Lys Val Glu Ala Lys Val Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Glu Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Gly Thr Thr Asn Lys Gly Gln Pro Trp Glu Val Thr Ser Val 
145                 150                 155                 160 


Trp Ile Ser Arg Phe Glu Glu Asp Gly Leu Met Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Ile Asp Ala Ala Gln Val Met Lys Thr Ile Trp Glu Asn Glu Leu 
            180                 185                 190         


Trp Trp Asn Ser Ser Asp Arg Leu His His Tyr Glu Trp Ile Pro Gly 
        195                 200                 205             


Pro Ala Gly Met Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  30
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  30

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Leu Ile Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Glu Asn Pro Glu Thr Asn Cys Arg Phe Val Ser Gln Pro Tyr Ile 
    50                  55                  60                  


Trp Asn Ala Phe Asn Thr Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Val Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Tyr Val Asn Thr Leu Trp 
            100                 105                 110         


Arg Val Asn Asn Cys Leu Lys Glu Gly Lys Val Glu Ala Lys Val Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Glu Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Asn Gly Thr Ser Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Val 
145                 150                 155                 160 


Trp Ile Thr Arg Phe Glu Asp Glu Gly Leu Met Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Ile Asp Ala Ala Gln Val Met Lys Thr Ile Trp Glu Asn Glu Ile 
            180                 185                 190         


Trp Trp Asn Ser Thr Asp Arg Val His His Tyr Glu Trp Ile Pro Gly 
        195                 200                 205             


Pro Ala Ala Met Pro Pro Ile Ala Glu Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  31
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 21

<400>  31

Met Arg Leu Ser Thr Leu Ser Ser Leu Leu Leu Gly Ser Ser Ser Ile 
1               5                   10                  15      


Val Phe Ala Arg Val Pro Pro Thr Val Asp Asn Gln Glu Pro Ile Lys 
            20                  25                  30          


Ser Thr Ser Tyr Phe Ile Asp Asp Pro Asp Phe Pro Ser His Phe Glu 
        35                  40                  45              


Phe Asp Asn Pro Glu Thr Asn Cys Arg Phe Val Thr Gln Pro Phe Ile 
    50                  55                  60                  


Trp Asn Ala Phe Asn Thr Val Ser Glu Asp Met Glu Ala Leu Phe Lys 
65                  70                  75                  80  


Tyr Ala His Pro Asp Leu His Val Arg Val Val Gly His His Pro Phe 
                85                  90                  95      


Ala Gly Tyr Tyr His Asn Pro Lys Met Ala Tyr Val Asn Thr Leu Trp 
            100                 105                 110         


Arg Val Asn Asn Cys Leu Lys Glu Gly Lys Val Glu Ala Lys Val Trp 
        115                 120                 125             


Ala Ile His Gly Gly Cys Glu Gln Ala Trp Ser Val Gln Glu Phe Tyr 
    130                 135                 140                 


Phe Gln Gly Thr Ser Asn Lys Gly Gln Pro Trp Asp Ile Thr Ser Val 
145                 150                 155                 160 


Trp Ile Thr Arg Phe Glu Glu Glu Gly Leu Met Arg Glu Ile Arg Thr 
                165                 170                 175     


Trp Ile Asp Ala Ala Gln Val Met Lys Thr Ile Trp Glu Asn Glu Leu 
            180                 185                 190         


Trp Trp Asn Ser Thr Asp Arg Val His His Tyr Glu Tyr Ile Pro Gly 
        195                 200                 205             


Pro Ala Gly Met Pro Pro Ile Ala Asn Lys Thr Glu Leu Gly Gly Glu 
    210                 215                 220                 


Leu 
225 


<210>  32
<211>  1087
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  32
atggtggcga caaagctttt ctccacggct ctggtggccg ccgccctggt gttaccgggc       60

tctgcgctca gcataatccc cttccagaag cccatggaga atccgcacct gtgtgatggc      120

accggcatcg tggaccccga cggcaactgc aacggggacg gtgtcattga tgagcctccc      180

gcacgtccac cacgcttcgg aaacccaccg ccgcacgagg gcagggacag ggatgggttc      240

aagttcgaga acccctccac ccagtgcaag tacatgtcgc agccggacct ctgggacaac      300

ttcaagtcgc tagagaagga catgagcaag atctttacca tgatccacaa ggacgtcgat      360

tttaccatcg tcggtcacca tcccggtgct gggcactaca ccgacctgct gcacttctac      420

accaatgccc tgcgtcgcta cagcgtctgc ttctcccagt accccgagta tttccgcatc      480

tatccccagg ccatccacgg aggctgcaat agcgagtggt ccgtccagga gattctcttc      540

ctcggccgta ccaaccacgg taagcaaccc tgattgagta tccaaaggga aatagagcta      600

acggtggata ggcgtcgact ttgatgtgat caacgtatgg gtcacccgct ggaaggacgg      660

ccagatggtc gaggtccgca cctacatcga ctccatgcgc atgactggct tgctccatga      720

gaacgagctc tggtggaact ccagcaccta cgaggagcat cccaactaca tcccgggccc      780

aacgggtttg ccagacctcg acgagctgcg cggtctgatg cgcaagccgg atggaagcag      840

gtacgacgac atgtagagag tgtcacggag taaggtcgtg atggatcaac gctgctaaat      900

gatggacgat gtgcaagaat tggaaacgaa atattgtaga tggatttcgc tcgttgctgt      960

tgttgctgat tgccatgttt tgttcgttga tatagttgag taaccagact gagatggatg     1020

agttggggta tatgttggtg tacataggtc aaccgacctc cctcatttaa tatggccctt     1080

gcactag                                                               1087


<210>  33
<211>  267
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  33

Met Val Ala Thr Lys Leu Phe Ser Thr Ala Leu Val Ala Ala Ala Leu 
1               5                   10                  15      


Val Leu Pro Gly Ser Ala Leu Ser Ile Ile Pro Phe Gln Lys Pro Met 
            20                  25                  30          


Glu Asn Pro His Leu Cys Asp Gly Thr Gly Ile Val Asp Pro Asp Gly 
        35                  40                  45              


Asn Cys Asn Gly Asp Gly Val Ile Asp Glu Pro Pro Ala Arg Pro Pro 
    50                  55                  60                  


Arg Phe Gly Asn Pro Pro Pro His Glu Gly Arg Asp Arg Asp Gly Phe 
65                  70                  75                  80  


Lys Phe Glu Asn Pro Ser Thr Gln Cys Lys Tyr Met Ser Gln Pro Asp 
                85                  90                  95      


Leu Trp Asp Asn Phe Lys Ser Leu Glu Lys Asp Met Ser Lys Ile Phe 
            100                 105                 110         


Thr Met Ile His Lys Asp Val Asp Phe Thr Ile Val Gly His His Pro 
        115                 120                 125             


Gly Ala Gly His Tyr Thr Asp Leu Leu His Phe Tyr Thr Asn Ala Leu 
    130                 135                 140                 


Arg Arg Tyr Ser Val Cys Phe Ser Gln Tyr Pro Glu Tyr Phe Arg Ile 
145                 150                 155                 160 


Tyr Pro Gln Ala Ile His Gly Gly Cys Asn Ser Glu Trp Ser Val Gln 
                165                 170                 175     


Glu Ile Leu Phe Leu Gly Arg Thr Asn His Gly Val Asp Phe Asp Val 
            180                 185                 190         


Ile Asn Val Trp Val Thr Arg Trp Lys Asp Gly Gln Met Val Glu Val 
        195                 200                 205             


Arg Thr Tyr Ile Asp Ser Met Arg Met Thr Gly Leu Leu His Glu Asn 
    210                 215                 220                 


Glu Leu Trp Trp Asn Ser Ser Thr Tyr Glu Glu His Pro Asn Tyr Ile 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Leu Pro Asp Leu Asp Glu Leu Arg Gly Leu Met 
                245                 250                 255     


Arg Lys Pro Asp Gly Ser Arg Tyr Asp Asp Met 
            260                 265         


<210>  34
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 33

<400>  34

Met Val Ala Thr Lys Leu Phe Ser Thr Ala Leu Val Ala Phe Ile Leu 
1               5                   10                  15      


Ser Leu Pro Ala Ser Ala Leu Ser Val Ile Pro Phe Gln Ser Pro Met 
            20                  25                  30          


Leu Asn Pro His Leu Cys Asp Gly Thr Gly Ile Val Asp Pro Asp Gly 
        35                  40                  45              


Asn Cys Asn Gly Asp Gly Val Ile Asp Glu Pro Pro Ala Arg Pro Pro 
    50                  55                  60                  


Arg Phe Gly Asn Pro Pro Pro His Glu Gly Arg Asp Arg Asp Gly Phe 
65                  70                  75                  80  


Lys Phe Glu Asn Pro Ser Thr Gln Cys Lys Tyr Met Ser Gln Pro Asp 
                85                  90                  95      


Leu Trp Asp Asn Phe Lys Ser Leu Glu Lys Asp Met Ser Lys Ile Phe 
            100                 105                 110         


Thr Leu Ile His Lys Asp Val Asp Phe Thr Ile Val Gly His His Pro 
        115                 120                 125             


Gly Ala Gly His Tyr Asn Asp Leu Leu His Phe Tyr Thr Asn Ala Leu 
    130                 135                 140                 


Arg Arg Tyr Ser Val Cys Phe Ser Gln Tyr Pro Glu Tyr Phe Arg Ile 
145                 150                 155                 160 


Tyr Pro Gln Ala Ile His Gly Gly Cys Asn Ser Glu Trp Ser Val Gln 
                165                 170                 175     


Glu Ile Leu Phe Leu Gly Arg Leu Asn His Gly Val Asp Phe Asp Val 
            180                 185                 190         


Ile Asn Val Trp Val Thr Arg Trp His Gln Gly Gln Met Val Glu Val 
        195                 200                 205             


Arg Thr Tyr Ile Asp Ser Met Arg Met Thr Gly Leu Leu His Arg Asn 
    210                 215                 220                 


Glu Leu Trp Trp Asn Ser Ser Thr Tyr Glu Glu His Pro Asn Tyr Ile 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Leu Pro Asp Leu Asp Glu Leu Glu Gly Leu Met 
                245                 250                 255     


Arg Lys Pro Asp Gly Ser Arg Tyr Asp Asp Met 
            260                 265         


<210>  35
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 33

<400>  35

Met Val Ala Thr Lys Leu Phe Ser Pro Ala Leu Val Ala Ala Ala Leu 
1               5                   10                  15      


Val Leu Pro Gly Thr Ala Leu Ser Phe Ile Pro Phe Gln Lys Pro Met 
            20                  25                  30          


Glu Gly Pro His Leu Cys Asp Gly Thr Gly Leu Val Asp Pro Asp Gly 
        35                  40                  45              


Asn Cys Asn Gly Asp Gly Val Ile Asp Glu Pro Pro Ala Pro Pro Pro 
    50                  55                  60                  


Arg Phe Gly Asn Pro Pro Pro His Glu Gly Lys Tyr Arg Asp Gly Phe 
65                  70                  75                  80  


Lys Phe Glu Asn Pro Ser Thr Gln Cys Lys Tyr Met Ser Gln Pro Asp 
                85                  90                  95      


Leu Trp Asp Val Phe Lys Ser Leu Glu Lys Asp Met Ser Lys Ile Phe 
            100                 105                 110         


Thr Met Ile His Lys Asp Val Asp Phe Thr Ile Val Gly His His Pro 
        115                 120                 125             


Gly Ala Gly His Tyr Thr Asp Leu Lys His Phe Tyr Thr Asn Ala Leu 
    130                 135                 140                 


Arg Arg Tyr Ser Val Cys Phe Ser Gln Tyr Pro Glu Tyr Phe Arg Ile 
145                 150                 155                 160 


Tyr Pro Gln Ala Ile His Gly Gly Cys Asn Glu Gln Trp Ser Val Gln 
                165                 170                 175     


Glu Ile Leu Phe Leu Gly Gln Met Asn His Gly Val Asp Phe Asp Val 
            180                 185                 190         


Ile Asn Val Trp Val Thr Arg Trp Lys Asp Gly Gln Met Val Glu Val 
        195                 200                 205             


Arg Thr Tyr Ile Asp Ser Met Arg Met Thr Gly Leu Leu His Glu Asn 
    210                 215                 220                 


Glu Leu Trp Trp Asn Ser Ser Thr Tyr Glu Glu His Pro Asn Tyr Ile 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Leu Pro Asp Leu Asp Glu Leu Arg Gly Leu Met 
                245                 250                 255     


Arg Lys Pro Asp Gly Ser Arg Tyr Asp Asp Met 
            260                 265         


<210>  36
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 33

<400>  36

Met Val Ala Phe Lys Leu Phe Ser Thr Ala Leu Val Ala Phe Ala Leu 
1               5                   10                  15      


Val Leu Pro Gly Ser Ala Leu Ser Ile Ile Ser Phe Gln Lys Pro Met 
            20                  25                  30          


Glu Lys Pro His Leu Cys Asp Gly Thr Gly Ile Val Asp Pro Asp Gly 
        35                  40                  45              


Asn Cys Asn Gly Asp Gly Val Ile Asp Ser Pro Pro Ala Arg Pro Pro 
    50                  55                  60                  


Arg Phe Gly Asn Pro Pro Pro His Glu Gly Arg Asp Arg Asp Gly Phe 
65                  70                  75                  80  


Lys Phe Glu Asn Pro Ser Thr Gln Cys Lys Tyr Met Ser Gln Pro Asp 
                85                  90                  95      


Leu Trp Asp Asn Phe Lys Asp Leu Glu Lys Asp Met Ser Lys Ile Phe 
            100                 105                 110         


Thr Met Ile His Lys Asp Val Asp Phe Thr Ile Val Gly His His Pro 
        115                 120                 125             


Gly Ala Gly His Tyr Thr Asp Leu Leu His Phe Tyr Thr Asn Ala Leu 
    130                 135                 140                 


Arg Arg Tyr Ser Val Cys Phe Ile Gln Tyr Pro Glu Tyr Phe Arg Ile 
145                 150                 155                 160 


Tyr Pro Gln Ala Ile His Gly Gly Cys Asn Ser Ala Trp Ser Val Gln 
                165                 170                 175     


Glu Ile Leu Phe Leu Gly Val Thr Asn His Gly Val Pro Phe Asp Val 
            180                 185                 190         


Ile Asn Val Trp Val Thr Arg Trp His Asp Gly Gln Met Val Glu Val 
        195                 200                 205             


Arg Thr Tyr Ile Asp Ser Pro Lys Met Thr Glu Leu Leu His Glu Asn 
    210                 215                 220                 


Glu Ile Trp Trp Asn Ser Ser Thr Phe Glu Glu His Leu Glu Tyr Ile 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Leu Pro Asp Leu Asp Glu Leu Arg Lys Leu Met 
                245                 250                 255     


Arg Lys Pro Asp Gly Ser Arg Tyr Asp Asp Met 
            260                 265         


<210>  37
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 33

<400>  37

Met Val Cys Thr Lys Tyr Phe Ser Thr Ala Leu Val Ala Ile Thr Leu 
1               5                   10                  15      


Val Leu Pro Gly Ser Ala Leu Ser Ile Ile Pro Phe Gln Ser Pro Met 
            20                  25                  30          


Asp Gly Pro His Leu Cys Asp Gly Thr Gly Ile Val Asp Pro Asp Gly 
        35                  40                  45              


Asn Cys Asn Gly Asp Gly Val Ile Asp Asp Pro Pro Ala Arg Pro Pro 
    50                  55                  60                  


Arg Phe Gly Asn Pro Pro Pro His Glu Gly Ala Pro Arg Asp Gly Phe 
65                  70                  75                  80  


Lys Phe Glu Asn Pro Ser Thr Gln Cys Lys Tyr Met Ser Gln Pro Asp 
                85                  90                  95      


Leu Trp Asp Ser Phe Lys Asp Leu Glu Lys Asp Met Ser Lys Ile Phe 
            100                 105                 110         


Thr Met Ile His Lys Asp Val Asp Phe Thr Ile Val Gly His His Pro 
        115                 120                 125             


Gly Ala Gly His Tyr Asn Asp Leu Met His Phe Tyr Thr Asn Ala Leu 
    130                 135                 140                 


Arg Arg Tyr Ser Val Cys Phe Ser Gln Tyr Pro Glu Tyr Phe Glu Ile 
145                 150                 155                 160 


Tyr Pro Val Ala Ile His Gly Gly Cys Asn Ser Glu Trp Ser Val Gln 
                165                 170                 175     


Glu Phe Asn Phe Ile Gly Leu Thr Asn Ser Gly Asp Asp Phe Asp Val 
            180                 185                 190         


Val Asn Val Trp Val Thr Arg Trp Lys Asp Gly Gln Met Val Glu Val 
        195                 200                 205             


Arg Thr Tyr Ile Asp Ser Met Arg Met Thr Glu Leu Leu His Glu Asn 
    210                 215                 220                 


Glu Leu Trp Trp Asn Ser Ser Thr Phe Glu Glu His Met Asn Tyr Ile 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Leu Pro Asp Leu Asp Glu Leu Arg Gly Phe Met 
                245                 250                 255     


Arg Lys Pro Asp Gly Ser Arg Tyr Asp Asp Met 
            260                 265         


<210>  38
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 33

<400>  38

Met Val Ala Thr Lys Tyr Phe Ser Gln Ala Leu Val Ala Phe Thr Leu 
1               5                   10                  15      


Val Leu Pro Ala Gly Ala Ala Ser Ile Ile Pro Phe Gln Lys Pro Met 
            20                  25                  30          


Glu Glu Pro His Leu Cys Asp Gly Thr Gly Ile Val Asp Pro Asp Gly 
        35                  40                  45              


Arg Cys Asn Gly Asp Gly Val Ile Asp Glu Pro Pro Ala Arg Pro Pro 
    50                  55                  60                  


Arg Phe Gly Asn Pro Pro Pro His Glu Gly Arg Asp Arg Asp Gly Phe 
65                  70                  75                  80  


Glu Phe Glu Asn Pro Ser Thr Gln Cys Lys Tyr Met Ser Gln Pro His 
                85                  90                  95      


Leu Trp Asp Ser Phe Lys Thr Leu Glu Lys Asp Met Thr Lys Ile Phe 
            100                 105                 110         


Thr Met Ile His Lys Asp Val His Phe Thr Ile Val Gly His His Pro 
        115                 120                 125             


Gly Ala Gly His Tyr His Asp Leu Leu His Phe Tyr Thr Asn Ala Leu 
    130                 135                 140                 


Arg Arg Tyr Ser Val Val Phe Ser Gln Tyr Pro Glu Tyr Phe Arg Ile 
145                 150                 155                 160 


Tyr Pro Gln Ala Ile His Gly Gly Cys Asn Glu Gln Trp Ser Val Gln 
                165                 170                 175     


Glu Ile Leu Phe Lys Gly Gln Thr Asn His Gly Val Thr Phe Asp Val 
            180                 185                 190         


Ile Asn Val Trp Val Thr Arg Trp Lys Asp Gly Gln Met Val Glu Val 
        195                 200                 205             


Arg Thr Tyr Ile Asp Gln Met Arg Met Thr Gly Leu Leu His Glu Asn 
    210                 215                 220                 


Glu Ile Trp Trp Asn Ser Ser Thr His Glu Asp His Ser Asn Tyr Ile 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Leu Pro Asp Leu Asp Glu Leu Arg Gly Leu Met 
                245                 250                 255     


Arg Lys Pro Asp Gly Ser Arg Tyr Asp Asp Met 
            260                 265         


<210>  39
<211>  1541
<212>  DNA
<213>  Talaromyces stipitatus

<400>  39
atgtcagacg gcaccctttt catccaagac tctcgtacat ccaaacagta taccatctcc       60

gtgacatctg atacaataac tgctgtggac ttccagaaga tcacctcgcc gacgggaaag      120

cttgccttat atgacccagg cctgcagaat acaattatta agaagactca aattaccggg      180

cggtatgtag ctggctctac tgcacgcatt ttgaataata ctaaacgcca tttttctagt      240

gaccctgtaa ctggaataac acttttcagg ggcctttcag caaaagagat ctggaaccgc      300

catgctgatt ttgaagatca tttccatctt ctagtttttg ggaagtatcc ctcaccagaa      360

gagagcgagg cgcttcgccg gcgccttgct gtgcaaatga cagttgttcc tgagaccgtt      420

atcaaggcgg tgcaggcttt tccgtaggta cttcccttcc tgcaaatatc tggcatcaaa      480

gctgatatac ccggctcgaa gacgtacatc acatcccctt cccatgatca tcgccggtct      540

ggccgcattc atttccgcag atccgtcctc tctaccggca atccgtggtg gcaatatcta      600

tcacggcaac cgcgctctct gcgatgaggg cgtcattcga gcaacagccg cttacgcagt      660

tgtcatgggc ctgatcaatt ctcacaggaa gcaactccct tacgtcccag cggaccccca      720

aaagtcattc tacgaaaacg tcttcgccat gatgcgctgt cccgttcacc acaactattt      780

ggttacgttc cgtgaaggca tggtattgaa tagtgacaat gggatgactc agtcgagcgt      840

cgtcttactt tcaacggcat cttcacttcc agacccaatc tcatgcctca taagtgcaat      900

tactgccgcg tatggacctt tacactacgg tgcgcaagaa gccggttcca caacactgaa      960

atcaatagga tcgttggata aggtgccaga attcttggaa caggtcaaac gacgtgagag     1020

aagattgttc gggtttggac accgactaca caagcgtgag gatccgcgat tagcatcggt     1080

gaagagatgg ttaaagatga tggattacac gccggatcag gaaccgttgt tggaattggc     1140

gcaagagatc gacaggcttg cgtcgtcgga tgagtatttt atcaagagga atttgagggc     1200

gaatgcagat ttctacaccc atttcttgtt taaagcatgg ttcgtatttg atgttctttc     1260

catcttttat tcaagggttt aatatggaat gcaggggttt cgattgggat atgctgtgtg     1320

ctgcaaacat gttccacaga atcattggtt taatggctca ctggcgcgaa gctatgggta     1380

agtgttgtcc tcccatagtc ctcttttgag atagaaactg acttcctaca gatcaaccga     1440

tcaaaatttt cagggctacg gatctctatg ttggaccagt ggtgattcaa gaagacaatc     1500

gtacagttct cgaagagccg aaaattcaat ccagattgtg a                         1541


<210>  40
<211>  438
<212>  PRT
<213>  Talaromyces stipitatus

<400>  40

Met Ser Asp Gly Thr Leu Phe Ile Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Val Asp Phe Gln 
            20                  25                  30          


Lys Ile Thr Ser Pro Thr Gly Lys Leu Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Arg Arg Arg Leu Ala Val 
            100                 105                 110         


Gln Met Thr Val Val Pro Glu Thr Val Ile Lys Ala Val Gln Ala Phe 
        115                 120                 125             


Pro Arg Thr Ser His Pro Leu Pro Met Ile Ile Ala Gly Leu Ala Ala 
    130                 135                 140                 


Phe Ile Ser Ala Asp Pro Ser Ser Leu Pro Ala Ile Arg Gly Gly Asn 
145                 150                 155                 160 


Ile Tyr His Gly Asn Arg Ala Leu Cys Asp Glu Gly Val Ile Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Met Gly Leu Ile Asn Ser His Arg Lys 
            180                 185                 190         


Gln Leu Pro Tyr Val Pro Ala Asp Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Met Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Ile Gly Ser Leu Asp 
        275                 280                 285             


Lys Val Pro Glu Phe Leu Glu Gln Val Lys Arg Arg Glu Arg Arg Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Lys Arg Trp Leu Lys Met Met Asp Tyr Thr Pro Asp Gln Glu 
                325                 330                 335     


Pro Leu Leu Glu Leu Ala Gln Glu Ile Asp Arg Leu Ala Ser Ser Asp 
            340                 345                 350         


Glu Tyr Phe Ile Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Trp Asp Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Ile Ile Gly Leu Met Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Met Asp Gln Pro Ile Lys Ile Phe Arg Ala Thr Asp Leu Tyr Val 
                405                 410                 415     


Gly Pro Val Val Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  41
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  41

Met Ser Asp Gly Thr Leu Phe Leu Asn Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Val Asp Phe Gln 
            20                  25                  30          


Lys Ile Thr Ser Pro Thr Gly Lys Leu Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Lys Lys Arg Leu Ala Val 
            100                 105                 110         


Gln Met Thr Val Val Pro Asp Thr Val Ile Lys Ala Val Gln Ala Phe 
        115                 120                 125             


Pro Arg Thr Ser His Pro Leu Pro Met Ile Ile Ala Gly Leu Ala Ala 
    130                 135                 140                 


Phe Leu Ser Ala Asp Pro Ser Ser Ile Pro Ala Ile Arg Gly Ala Asn 
145                 150                 155                 160 


Ile Tyr His Gly Asn Arg Ala Leu Cys Asp Glu Gly Val Ile Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Leu Gly Leu Ile Asn Ser His Arg Arg 
            180                 185                 190         


Gln Leu Pro Tyr Val Pro Ala Asp Pro Gln Lys Ser Tyr Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Met Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Phe Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Leu Gly Thr Leu Asp 
        275                 280                 285             


Lys Val Pro Glu Phe Leu Glu Gln Val Lys Arg Lys Glu Arg Arg Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Lys Asp Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Lys Arg Trp Leu Lys Met Leu Asp Tyr Thr Pro Asp Gln Glu 
                325                 330                 335     


Pro Leu Leu Glu Ile Ala Gln Glu Ile Asp Arg Leu Ala Ser Ser Asp 
            340                 345                 350         


Glu Tyr Phe Ile Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Trp Asp Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Ile Ile Gly Leu Met Ala His Tyr Arg Glu 
385                 390                 395                 400 


Ala Met Asp Asn Pro Ile Lys Ile Phe Arg Ala Thr Asp Leu Tyr Val 
                405                 410                 415     


Gly Pro Val Val Ile Gln Glu Glu Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  42
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  42

Met Ser Asp Gly Thr Leu Phe Leu Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Val Asp Phe Gln 
            20                  25                  30          


Lys Ile Thr Ser Pro Thr Gly Lys Leu Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Ile 
    50                  55                  60                  


Thr Gly Ile Thr Val Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Arg Arg Arg Leu Ala Val 
            100                 105                 110         


Gln Met Thr Val Val Pro Glu Thr Val Ile Lys Ala Val Gln Gly Phe 
        115                 120                 125             


Pro Arg Thr Thr His Pro Leu Pro Met Ile Ile Ala Ala Leu Ala Ala 
    130                 135                 140                 


Phe Ile Ser Ala Asp Pro Ser Ser Val Pro Ala Ile Arg Gly Gly Asn 
145                 150                 155                 160 


Ile Tyr His Gly Asn Arg Ala Leu Cys Asp Glu Gly Val Val Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Met Gly Leu Leu Asn Ser His Arg Lys 
            180                 185                 190         


Gln Leu Pro Tyr Val Pro Ala Asp Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Leu Arg Cys Pro Val His His Asn Phe Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Arg Ser Ile Gly Ser Leu Glu 
        275                 280                 285             


Lys Ile Pro Glu Trp Leu Glu Gln Ile Lys Arg Arg Glu Arg Arg Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Arg Arg Trp Met Lys Met Ile Asp Tyr Thr Pro Asp Gln Glu 
                325                 330                 335     


Pro Leu Leu Glu Leu Ala Gln Glu Ile Asp Arg Leu Ala Ser Ser Asp 
            340                 345                 350         


Glu Tyr Phe Ile Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Tyr Asp Leu Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Ile Ile Gly Leu Met Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Met Glu Gln Pro Ile Lys Ile Phe Arg Ala Thr Asp Leu Tyr Val 
                405                 410                 415     


Gly Pro Val Val Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  43
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  43

Met Ser Asp Ala Ser Leu Phe Ile Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Met Thr Ala Val Asp Phe Gln 
            20                  25                  30          


Lys Leu Thr Ser Pro Thr Ala Lys Leu Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Lys Arg Arg Leu Ala Val 
            100                 105                 110         


Gln Met Thr Ile Val Pro Glu Thr Val Ile Lys Ala Val Gln Ala Phe 
        115                 120                 125             


Pro Arg Thr Thr His Pro Leu Pro Val Ile Ile Ala Gly Leu Ala Ala 
    130                 135                 140                 


Phe Ile Ser Ala Asp Pro Ser Ser Met Pro Ala Ile Arg Gly Gly Asn 
145                 150                 155                 160 


Leu Trp His Ala Asn Arg Ala Leu Cys Asp Glu Gly Met Ile Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Met Gly Leu Ile Asn Ser His Arg Lys 
            180                 185                 190         


Gln Leu Pro Tyr Val Pro Ala Asp Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Ile Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Leu Gly Ser Val Glu 
        275                 280                 285             


Lys Ile Pro Glu Tyr Leu Glu Asn Val Lys Arg Arg Glu Arg Arg Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Lys Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Arg Arg Trp Leu Lys Met Met Asp Tyr Thr Pro Asp Gln Asp 
                325                 330                 335     


Pro Leu Leu Glu Leu Ala Gln Glu Ile Asp Lys Leu Ala Ser Ser Asp 
            340                 345                 350         


Glu Phe Phe Ile Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Trp Glu Leu Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Ile Ile Gly Leu Ile Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Met Asp Gln Pro Ile Lys Ile Phe Arg Ala Thr Asp Val Tyr Val 
                405                 410                 415     


Gly Pro Val Leu Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  44
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  44

Met Ser Asp Ala Thr Leu Phe Ile Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Val Asp Phe Gln 
            20                  25                  30          


Lys Ile Thr Ser Pro Thr Gly Lys Ile Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Leu Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Lys His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Tyr Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Arg Arg Arg Leu Ala Val 
            100                 105                 110         


Gln Met Thr Val Val Pro Glu Thr Val Ile Lys Ala Val Gln Ala Phe 
        115                 120                 125             


Pro Arg Thr Ser His Pro Leu Pro Met Ile Ile Ala Gly Leu Ala Ala 
    130                 135                 140                 


Phe Ile Thr Ala Asp Pro Ser Ser Leu Pro Ala Ile Arg Gly Gly Asn 
145                 150                 155                 160 


Ile Phe His Ala Asn Arg Ala Leu Cys Glu Glu Ala Val Ile Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Met Gly Leu Ile Asn Ser His Lys Lys 
            180                 185                 190         


Gln Leu Pro Tyr Val Pro Ala Asp Pro Asn Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Met Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Thr Ser Thr Leu Lys Ser Ile Gly Ser Ile Glu 
        275                 280                 285             


Lys Val Pro Glu Tyr Leu Glu Gln Val Lys Lys Lys Glu Arg Arg Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Lys Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Lys Arg Trp Leu Lys Met Met Glu Tyr Thr Pro Asp Gln Glu 
                325                 330                 335     


Pro Leu Leu Asp Ile Ala Gln Glu Ile Asp Arg Ile Ala Ser Ser Asp 
            340                 345                 350         


Glu Tyr Phe Val Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Trp Glu Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Met Ile Gly Leu Leu Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Leu Asp Gln Pro Ile Lys Ile Phe Arg Ala Thr Asp Ile Tyr Val 
                405                 410                 415     


Gly Pro Val Leu Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  45
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  45

Met Ser Asp Gly Ser Leu Phe Ile Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Ile Asp Phe Gln 
            20                  25                  30          


Lys Ile Ser Ser Pro Thr Gly Lys Leu Ala Leu Phe Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Glu Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Arg Arg Arg Leu Ala Val 
            100                 105                 110         


Gln Met Thr Met Val Pro Glu Thr Leu Ile Lys Ala Val Gln Ala Phe 
        115                 120                 125             


Pro Arg Thr Ser His Pro Leu Pro Met Ile Ile Ala Ala Leu Ala Ala 
    130                 135                 140                 


Phe Ile Ser Ala Asp Pro Ser Ser Ile Pro Ala Ile Lys Ala Gly Asn 
145                 150                 155                 160 


Ile Tyr His Ala Asn Arg Ala Val Cys Asp Glu Ala Val Ile Arg Ala 
                165                 170                 175     


Thr Ala Ala Phe Ala Val Val Met Gly Leu Ile Asn Ser His Arg Lys 
            180                 185                 190         


Gln Leu Pro Tyr Ile Pro Ala Asp Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Leu Arg Cys Pro Ile His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Leu Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Trp Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Leu Gly Ser Leu Glu 
        275                 280                 285             


Arg Ile Pro Glu Tyr Leu Glu Gln Ile Lys Arg Lys Glu Lys Lys Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Lys Arg Phe Leu Lys Met Leu Asp Tyr Thr Pro Asp Gln Glu 
                325                 330                 335     


Pro Leu Ile Glu Val Ala Gln Glu Ile Asp Lys Ile Ala Ser Ser Glu 
            340                 345                 350         


Asp Tyr Phe Val Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Trp Glu Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Val Ile Gly Leu Leu Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Met Asp Gln Pro Leu Lys Ile Phe Arg Ala Thr Asp Leu Tyr Val 
                405                 410                 415     


Gly Pro Leu Leu Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  46
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  46

Met Ser Asp Gly Thr Leu Phe Ile Gln Asp Ser Arg Thr Ser Arg Gln 
1               5                   10                  15      


Phe Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Ile Asp Phe Gln 
            20                  25                  30          


Lys Leu Thr Ser Pro Thr Gly Lys Ile Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Glu Glu Ser Glu Ala Leu Lys Lys Arg Leu Ala Val 
            100                 105                 110         


Gln Leu Thr Val Val Pro Glu Thr Ile Leu Lys Ala Val Gln Ala Phe 
        115                 120                 125             


Pro Lys Thr Ser His Pro Leu Pro Val Ile Val Ala Ala Leu Ala Ala 
    130                 135                 140                 


Phe Ile Thr Ala Asp Pro Ser Ser Leu Pro Ala Ile Arg Ala Gly Asn 
145                 150                 155                 160 


Leu Tyr His Gly Asn Lys Ala Ile Cys Glu Glu Ala Val Met Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Leu Val Met Gly Met Ile Asn Ser His Arg Lys 
            180                 185                 190         


Gln Leu Pro Tyr Val Pro Ala Asp Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Met Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Ile Gly Thr Leu Asp 
        275                 280                 285             


Lys Val Pro Glu Phe Leu Glu Gln Val Lys Arg Lys Glu Arg Lys Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Arg Arg Tyr Leu Lys Met Val Asp Tyr Ser Pro Asp Gln Asp 
                325                 330                 335     


Pro Leu Leu Glu Leu Ala Gln Glu Ile Asp Arg Val Ala Ser Ser Glu 
            340                 345                 350         


Glu Phe Phe Ile Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Arg Ala Trp Gly Phe Asp Trp Glu Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Leu Ile Gly Leu Ile Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Ile Glu Gln Pro Ile Lys Ile Phe Arg Ala Ser Asp Val Tyr Leu 
                405                 410                 415     


Gly Pro Val Val Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  47
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  47

Met Ser Asp Ala Ser Leu Phe Leu Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Thr Ala Ile Asp Phe Gln 
            20                  25                  30          


Lys Ile Thr Ser Pro Thr Gly Lys Val Ala Val Phe Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Val Ile Lys Lys Thr Asn Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Val Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Gln 
65                  70                  75                  80  


Lys His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Arg 
                85                  90                  95      


Tyr Pro Thr Pro Asp Glu Ser Glu Ala Leu Lys Arg Lys Leu Ala Val 
            100                 105                 110         


Gln Met Thr Ile Val Pro Asp Thr Met Leu Lys Ala Val Gln Gly Phe 
        115                 120                 125             


Pro Lys Thr Ser His Pro Leu Pro Met Ile Ile Ala Ala Leu Ala Ala 
    130                 135                 140                 


Phe Ile Ser Ala Glu Pro Ser Ser Val Pro Ala Met Lys Gly Gly Asn 
145                 150                 155                 160 


Leu Tyr His Ala Asn Arg Ala Leu Cys Glu Glu Gly Val Leu Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Met Gly Leu Ile Asn Ser His Lys Arg 
            180                 185                 190         


Gln Leu Pro Phe Ile Pro Ala Asp Pro Gln Lys Ser Trp Tyr Glu Asn 
        195                 200                 205             


Val Phe Gly Met Leu Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Leu Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Leu Ala Ser Val Glu 
        275                 280                 285             


Lys Val Pro Glu Tyr Leu Asp Gln Val Lys Arg Arg Glu Arg Lys Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Lys Arg Phe Leu Lys Met Val Asp Tyr Thr Pro Asp Gln Glu 
                325                 330                 335     


Pro Leu Leu Asp Ile Ala Gln Glu Ile Asp Arg Leu Ala Thr Ser Glu 
            340                 345                 350         


Glu Tyr Phe Ile Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Arg Gly Trp Gly Phe Asp Trp Glu Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Val Val Gly Leu Leu Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Leu Asp Gln Pro Ile Arg Ile Phe Arg Ala Ser Glu Val Tyr Val 
                405                 410                 415     


Gly Pro Ile Val Ile Gln Glu Glu Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  48
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  48

Met Ser Asp Ala Ser Leu Phe Val Gln Asp Ser Arg Ser Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Thr Asp Thr Ile Thr Ala Val Asp Phe Gln 
            20                  25                  30          


Lys Leu Thr Ser Pro Thr Gly Lys Leu Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Asn Asn Thr Ile Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Thr Gly Ile Thr Ile Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Thr Pro Glu Glu Ser Glu Ala Leu Arg Arg Lys Leu Gly Val 
            100                 105                 110         


Asn Leu Thr Met Val Pro Glu Thr Ile Val Arg Ala Val Asn Ala Phe 
        115                 120                 125             


Pro Lys Ser Ser His Pro Leu Pro Val Ile Ile Ala Ala Leu Gly Ala 
    130                 135                 140                 


Phe Ile Thr Ala Asp Pro Thr Ser Leu Pro Ala Ile Lys Gly Gly Asn 
145                 150                 155                 160 


Leu Tyr His Ala Gln Lys Ala Val Cys Glu Glu Ala Val Leu Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Met Gly Met Val Asn Thr His Arg Arg 
            180                 185                 190         


Gln Met Pro Phe Leu Pro Ala Glu Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Met Arg Cys Pro Val His His Asn Phe Val Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Leu Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Tyr Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Val Gly Thr Leu Asp 
        275                 280                 285             


Arg Val Pro Glu Phe Leu Glu Gln Ile Lys Arg Arg Glu Arg Arg Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Arg Arg Phe Val Lys Met Leu Asp Tyr Thr Pro Glu Asn Asp 
                325                 330                 335     


Pro Leu Leu Glu Leu Ala Gln Glu Ile Asp Arg Leu Ala Ser Ser Glu 
            340                 345                 350         


Asp Tyr Phe Val Lys Arg Asn Leu Arg Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Arg Ala Trp Gly Phe Asp Trp Glu Met Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Ile Ile Gly Leu Met Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Met Glu Gln Pro Leu Arg Ile Phe Arg Ala Thr Asp Leu Tyr Val 
                405                 410                 415     


Gly Pro Leu Val Ile Gln Glu Glu Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  49
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  49

Met Ser Asp Ala Thr Leu Phe Val Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Ser Asp Thr Ile Ser Ala Ile Asp Phe Gln 
            20                  25                  30          


Lys Met Thr Thr Pro Ser Gly Lys Met Ala Leu Phe Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Val Ile Lys Lys Thr Gln Ile Thr Gly Arg Asp Pro Val 
    50                  55                  60                  


Ser Gly Val Thr Leu Phe Arg Gly Leu Ser Ala Lys Glu Ile Trp Gln 
65                  70                  75                  80  


Arg His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Tyr Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Asp Glu Ser Asp Ala Leu Lys Lys Arg Leu Ala Val 
            100                 105                 110         


Gln Leu Ser Ile Val Pro Asp Thr Met Ile Lys Ala Val Gln Gly Phe 
        115                 120                 125             


Pro Arg Thr Ser His Pro Leu Pro Val Ile Ile Ala Ala Leu Ala Ala 
    130                 135                 140                 


Phe Ile Thr Ala Asp Pro Ser Ser Leu Pro Ala Val Lys Gly Ala Asn 
145                 150                 155                 160 


Leu Tyr His Ala Asn Arg Ala Val Cys Asp Glu Ala Ile Leu Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Val Val Ile Gly Leu Leu Asn Ser His Lys Arg 
            180                 185                 190         


Gln Leu Pro Tyr Met Pro Ala Asp Pro Gln Lys Ser Phe Tyr Glu Asn 
        195                 200                 205             


Val Phe Gly Met Leu Arg Cys Pro Ile His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Ala Met Val Leu Asn Ser Asp Asn Gly Met Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Ser Ala Ala Trp Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Leu Gly Ser Leu Asp 
        275                 280                 285             


Arg Ile Pro Asp Tyr Leu Asp Gln Leu Lys Arg Arg Glu Lys Lys Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Arg Lys Phe Leu Arg Met Met Glu Tyr Ser Pro Asp Asn Asp 
                325                 330                 335     


Pro Leu Val Asp Ile Ala Gln Glu Ile Asp Arg Met Ala Ser Ser Glu 
            340                 345                 350         


Asp Tyr Phe Leu Lys Arg Asn Leu Lys Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Arg Gly Trp Gly Phe Asp Trp Glu Met Leu Cys Gly 
    370                 375                 380                 


Ala Asn Met Phe His Arg Leu Leu Gly Leu Leu Ala His Trp Lys Glu 
385                 390                 395                 400 


Ala Leu Glu Gln Pro Leu Arg Ile Phe Arg Ala Thr Glu Ile Tyr Ile 
                405                 410                 415     


Gly Pro Leu Val Ile Gln Glu Asp Asn Arg Thr Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  50
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 40

<400>  50

Met Ser Glu Gly Thr Leu Phe Leu Gln Asp Ser Arg Thr Ser Lys Gln 
1               5                   10                  15      


Tyr Thr Ile Ser Val Thr Thr Asp Thr Met Thr Ala Ile Asp Phe Gln 
            20                  25                  30          


Lys Leu Thr Ser Pro Thr Gly Lys Leu Ala Leu Tyr Asp Pro Gly Leu 
        35                  40                  45              


Gln Asn Thr Val Val Lys Arg Thr Asn Ile Thr Gly Arg Asp Pro Leu 
    50                  55                  60                  


Thr Gly Leu Thr Val Phe Arg Gly Leu Thr Ala Lys Glu Ile Trp Asn 
65                  70                  75                  80  


Lys His Ala Asp Phe Glu Asp His Phe His Leu Leu Val Phe Gly Lys 
                85                  90                  95      


Tyr Pro Ser Pro Asp Glu Ser Asp Ala Leu Arg Arg Arg Leu Ala Val 
            100                 105                 110         


Gln Ile Ser Ile Val Pro Asp Thr Leu Ile Arg Ala Val Gln Gly Phe 
        115                 120                 125             


Pro Lys Ser Ser His Pro Leu Pro Val Ile Leu Ala Ala Leu Ala Ala 
    130                 135                 140                 


Phe Leu Thr Ala Asp Pro Ser Thr Ile Pro Ala Ile Arg Gly Ala Asn 
145                 150                 155                 160 


Leu Tyr His Gly Gln Arg Ala Leu Cys Glu Asp Ala Val Leu Arg Ala 
                165                 170                 175     


Thr Ala Ala Tyr Ala Leu Val Ile Gly Met Ile Asn Ser His Arg Arg 
            180                 185                 190         


Gln Val Pro Phe Ile Pro Ala Asp Pro Asn Lys Ser Tyr Tyr Glu Asn 
        195                 200                 205             


Val Phe Ala Met Ile Arg Cys Pro Val His His Asn Tyr Leu Val Thr 
    210                 215                 220                 


Phe Arg Glu Gly Met Val Leu Asn Ser Asp Asn Gly Leu Thr Gln Ser 
225                 230                 235                 240 


Ser Val Val Leu Leu Ser Thr Ala Ser Ser Leu Pro Asp Pro Ile Ser 
                245                 250                 255     


Cys Leu Ile Ser Ala Ile Thr Ala Ala Trp Gly Pro Leu His Tyr Gly 
            260                 265                 270         


Ala Gln Glu Ala Gly Ser Thr Thr Leu Lys Ser Ile Gly Thr Val Glu 
        275                 280                 285             


Arg Ile Pro Glu Tyr Leu Asp Gln Ile Lys Arg Lys Glu Lys Lys Leu 
    290                 295                 300                 


Phe Gly Phe Gly His Arg Leu His Lys Arg Glu Asp Pro Arg Leu Ala 
305                 310                 315                 320 


Ser Val Lys Lys Trp Val Lys Met Met Asp Tyr Thr Pro Asp Asn Asp 
                325                 330                 335     


Pro Val Ile Asp Met Ala Gln Glu Ile Asp Arg Val Ala Thr Ser Glu 
            340                 345                 350         


Asp Tyr Phe Leu Lys Arg Asn Leu Lys Ala Asn Ala Asp Phe Tyr Thr 
        355                 360                 365             


His Phe Leu Phe Lys Ala Trp Gly Phe Asp Trp Glu Leu Leu Cys Ala 
    370                 375                 380                 


Ala Asn Met Phe His Arg Leu Val Gly Leu Met Ala His Trp Arg Glu 
385                 390                 395                 400 


Ala Leu Asp Gln Pro Ile Arg Ile Phe Arg Ala Thr Asp Ile Tyr Ile 
                405                 410                 415     


Gly Pro Val Leu Ile Asn Glu Asp Asn Arg Ser Val Leu Glu Glu Pro 
            420                 425                 430         


Lys Ile Gln Ser Arg Leu 
        435             


<210>  51
<211>  1598
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  51
atgtcgcatg gagctctaca tatccgagac tcccgcacat cgcgggagta tgagatcccc       60

atccggcgca acaccgtcct cgccaccgat ctcaagcaga tcaaggcgtc cccggtgggc      120

gcggatcgag cggacaaagt gggcgatggc ctgcgggtct ttgatccggg tctcaagaac      180

acctgcgtgg tggagaccaa catgacatat acgtagggaa cgggtccaag agagttcccc      240

cccgggggaa ggttctttat ttcactaatg ctcaatttag ggacggacat cgcgggctgt      300

tgctttttcg gggctatgcc ctggagcaac tatggcaggc cgagttcgag gacatgctgc      360

atctcttggt ctggggcaaa tatcccacgc cgtctcagcg agaggcgttg cgtctgacct      420

tggccacgct catgtcgacc acgcccaaac atgtcgcgga ggtgattgag acattcccgt      480

aggtcttcta ctgtgctttt catcgtccat cacgatcacc ttgaatgaat gaagaactga      540

accccctgca gtccgacaag ccccccgatg cccatgattg tggccgggct gtccgcgtat      600

ctggcccacc atgccgactc catcccagcc tgtgccgggg gcaacatcta ccatggaaat      660

cccgaacaga ctgaccgtgc cattctccgg acggcagccg cctacgcggt ggtgatgggc      720

atggcggcca gccaccgtcg cggcatcgcc ttcacgccgg ccacgacgga taacacctac      780

tttgagaacc tgttcatcat gatgggcctg gttgaaccgt acaccggtcg tccagacccg      840

gtgaagctgt cctgcttccg gcggtttgcg gcgctcaact ccgagcacgg catggcgctg      900

tcctcgtttg cgatggtggt aaccgcctcc tcgctgacgg atcccatctc gggcctcatc      960

agctccctgg tggctgcgta cgggcccctg cactttggcg ccccggaggc ggaatacaaa     1020

accatccaag cggtcggcag cgtcgaccag gtgccggctt ttctggagga ggtcaagtct     1080

ggcaagcggc ggctgtttgg gtacggccat cgcacgtaca cgacgatcga cccccgggtg     1140

aagcccatca aagatatgct cttcagcgag ctggacgggg actcggatcc gctggtcaag     1200

gtggcgcggg agatcgatcg cctctcgtcg accgatgagt atttcatcaa acgaaaactg     1260

catgcgaacg cggactttta cggaaccttt ttctttaatc gcctgtaagt tgtttttctg     1320

ttgattgcag tggatgacaa ttgaccggtc gggtcgtagg ggattccaac cggaggaaat     1380

cccggttgca atggtagcac agcggttggt gggcatcctg gcgcattatc gggagtccat     1440

gtgtaggtcc agccgatttc caactttcaa gcaagggcaa gagagctgat aaaatgcccg     1500

cagtgaaaaa caaaatccgc ctcttccggc ccacgcacgt ctacacgggg gagaccgaac     1560

cagtgctcga gatgacggcg ccgtcggcga agctatga                             1598


<210>  52
<211>  446
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  52

Met Ser His Gly Ala Leu His Ile Arg Asp Ser Arg Thr Ser Arg Glu 
1               5                   10                  15      


Tyr Glu Ile Pro Ile Arg Arg Asn Thr Val Leu Ala Thr Asp Leu Lys 
            20                  25                  30          


Gln Ile Lys Ala Ser Pro Val Gly Ala Asp Arg Ala Asp Lys Val Gly 
        35                  40                  45              


Asp Gly Leu Arg Val Phe Asp Pro Gly Leu Lys Asn Thr Cys Val Val 
    50                  55                  60                  


Glu Thr Asn Met Thr Tyr Thr Asp Gly His Arg Gly Leu Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ala Leu Glu Gln Leu Trp Gln Ala Glu Phe Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Gly Lys Tyr Pro Thr Pro Ser Gln Arg Glu 
            100                 105                 110         


Ala Leu Arg Leu Thr Leu Ala Thr Leu Met Ser Thr Thr Pro Lys His 
        115                 120                 125             


Val Ala Glu Val Ile Glu Thr Phe Pro Pro Thr Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Ile Val Ala Gly Leu Ser Ala Tyr Leu Ala His His Ala Asp Ser 
145                 150                 155                 160 


Ile Pro Ala Cys Ala Gly Gly Asn Ile Tyr His Gly Asn Pro Glu Gln 
                165                 170                 175     


Thr Asp Arg Ala Ile Leu Arg Thr Ala Ala Ala Tyr Ala Val Val Met 
            180                 185                 190         


Gly Met Ala Ala Ser His Arg Arg Gly Ile Ala Phe Thr Pro Ala Thr 
        195                 200                 205             


Thr Asp Asn Thr Tyr Phe Glu Asn Leu Phe Ile Met Met Gly Leu Val 
    210                 215                 220                 


Glu Pro Tyr Thr Gly Arg Pro Asp Pro Val Lys Leu Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Ser Glu His Gly Met Ala Leu Ser Ser Phe 
                245                 250                 255     


Ala Met Val Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Gly Leu 
            260                 265                 270         


Ile Ser Ser Leu Val Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Pro 
        275                 280                 285             


Glu Ala Glu Tyr Lys Thr Ile Gln Ala Val Gly Ser Val Asp Gln Val 
    290                 295                 300                 


Pro Ala Phe Leu Glu Glu Val Lys Ser Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Thr Thr Ile Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Asp Met Leu Phe Ser Glu Leu Asp Gly Asp Ser Asp Pro Leu Val 
            340                 345                 350         


Lys Val Ala Arg Glu Ile Asp Arg Leu Ser Ser Thr Asp Glu Tyr Phe 
        355                 360                 365             


Ile Lys Arg Lys Leu His Ala Asn Ala Asp Phe Tyr Gly Thr Phe Phe 
    370                 375                 380                 


Phe Asn Arg Leu Gly Phe Gln Pro Glu Glu Ile Pro Val Ala Met Val 
385                 390                 395                 400 


Ala Gln Arg Leu Val Gly Ile Leu Ala His Tyr Arg Glu Ser Met Leu 
                405                 410                 415     


Lys Asn Lys Ile Arg Leu Phe Arg Pro Thr His Val Tyr Thr Gly Glu 
            420                 425                 430         


Thr Glu Pro Val Leu Glu Met Thr Ala Pro Ser Ala Lys Leu 
        435                 440                 445     


<210>  53
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 52

<400>  53

Met Ser Ala Gly Ala Leu His Ile Arg Asp Ser Arg Thr Ser Arg Glu 
1               5                   10                  15      


Tyr Glu Ile Pro Ile Arg Asn Asn Thr Val Leu Ala Thr Asp Leu Lys 
            20                  25                  30          


Gln Ile Lys Ala Ser Pro Val Gly Ala Asp Arg Ala Asp Lys Val Gly 
        35                  40                  45              


Asp Gly Leu Arg Val Leu Asp Pro Gly Leu Lys Asn Thr Cys Val Val 
    50                  55                  60                  


Glu Thr Asn Met Thr Phe Thr Asp Gly His Arg Gly Leu Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ala Leu Glu Gln Leu Trp Gln Pro Glu Phe Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Gly Lys Tyr Pro Thr Pro Ser Gln Arg Glu 
            100                 105                 110         


Ala Leu Arg Leu Arg Leu Ala Thr Phe Met Ser Thr Thr Pro Lys His 
        115                 120                 125             


Val Ala Glu Asp Ile Glu Arg Phe Pro Gln Thr Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Ile Val Ala Gly Leu Ser Ala Tyr Leu Ala His His Ala Asp Ser 
145                 150                 155                 160 


Ile Pro Ala Cys Ala Gly Gly Asn Ile Tyr Ile Gly Asn Pro Glu Gln 
                165                 170                 175     


Thr Asp Arg Ala Ile Leu Arg Thr Ala Ala Ala Tyr Ala Val Val Met 
            180                 185                 190         


Gly Met Ala Ala Ser His Arg Arg Gly Ile Ala Phe Thr Pro Ala Thr 
        195                 200                 205             


Thr Asp Asn Thr Tyr Phe Glu Asn Leu Phe Ile Met Met Gly Leu Val 
    210                 215                 220                 


Glu Gln Arg Thr Gly Arg Pro Asp Pro Val Ala Leu Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Ser Glu His Gly Met Ala Leu Ser Ser Phe 
                245                 250                 255     


Ala Met Val Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Gly Leu 
            260                 265                 270         


Ile Ser Ser Leu Val Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Pro 
        275                 280                 285             


Glu Ala Glu Tyr Lys Thr Ile Gln Ala Val Gly Ser Val Asp Gln Val 
    290                 295                 300                 


Pro Ala Phe Leu Glu Glu Val Lys Ser Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Thr Glu Ile Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Asp Met Leu Phe Arg Glu Leu Asp Asp Asp Gln Asp Pro Leu Val 
            340                 345                 350         


Lys Val Ala Arg Glu Ile Asp Arg Leu Ser Ser Thr Asp Glu Tyr Phe 
        355                 360                 365             


Ile Lys Arg Lys Leu Ala Ala Asn Ala Asp Phe Tyr Gly Thr Phe Phe 
    370                 375                 380                 


Phe Lys Arg Leu Gly Phe Gln Phe Glu Glu Ile Pro Val Ala Met Val 
385                 390                 395                 400 


Ala Gln Arg Leu Val Gly Ile Leu Ala His Tyr Arg Glu Ser Met Leu 
                405                 410                 415     


Lys Leu Lys Gly Arg Leu Phe Arg Pro Thr His Val Tyr Thr Gly Glu 
            420                 425                 430         


Thr Glu Pro Val Leu Glu Met Thr Ala Pro Ser Ala Lys Leu 
        435                 440                 445     


<210>  54
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 52

<400>  54

Met Ser His Gly Ala Leu His Ile Arg Asp Ser Arg Pro Ser Arg Glu 
1               5                   10                  15      


Tyr Glu Ile Pro Ile Arg Arg Asn Thr Val Leu Ala Val Asp Leu Lys 
            20                  25                  30          


Gln Ile Lys Ala Ser Pro Val Gly Ala Asp Arg Ala Asp Lys Val Gly 
        35                  40                  45              


Asp Gly Leu Arg Val Phe Asp Pro Gly Leu Lys Asn Thr Cys Val Val 
    50                  55                  60                  


Val Thr Asn Met Thr Tyr Thr Asp Gly His Arg Gly Leu Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ala Leu Glu Gln Leu Trp Gln Ala Glu Phe Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Gly Lys Tyr Pro Thr Pro Ser Gln Arg Glu 
            100                 105                 110         


Ala Leu Arg Leu Thr Leu Lys Thr Phe Met Ser Thr Thr Pro Lys Phe 
        115                 120                 125             


Val Ala Glu Val Ile Glu Thr Phe Pro Pro Thr Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Ile Val Ala Gly Leu Ser Ala Tyr Leu Ala His His Ala Asp Ser 
145                 150                 155                 160 


Ile Pro Tyr Cys Ala Gly Gly Asn Ile Phe His Thr Asn Pro Glu Gln 
                165                 170                 175     


Thr Thr Arg Ala Ile Leu Arg Thr Ala Ala Ala Tyr Ala Val Val Met 
            180                 185                 190         


Gly Met Ala Ala Ser His Arg Arg Gly Ile Pro Phe Thr Pro Ala Thr 
        195                 200                 205             


Thr Asp Asn Thr Tyr Phe Glu Asn Leu Phe Ile Met Met Gly Leu Val 
    210                 215                 220                 


Glu Pro Arg Thr Gly Arg Pro Asp Pro Val Lys Leu Ser Cys Phe Arg 
225                 230                 235                 240 


Leu Phe Ala Ala Leu Asn Ser Glu His Gly Met Ala Leu Ser Ser Phe 
                245                 250                 255     


Ala Met Val Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Gly Leu 
            260                 265                 270         


Ile Ser Ser Leu Val Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Pro 
        275                 280                 285             


Glu Ala Glu Tyr Ala Thr Ile Glu Ala Val Gly Ser Val Asp Gln Val 
    290                 295                 300                 


Pro Ser Phe Leu Glu Glu Val Lys Ser Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Thr Thr Ile Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Asp Met Leu Phe Ser Glu Leu Ala Gly Gln Ser Asp Pro Asp Val 
            340                 345                 350         


Lys Val Ala Arg Glu Ile Asp Arg Leu Ser Ser Thr Asp Glu Tyr Phe 
        355                 360                 365             


Ile Lys Arg Lys Leu Val Ala Asn Ala Asp Phe Tyr Gly Thr Phe Phe 
    370                 375                 380                 


Phe Asn Arg Leu Gly Phe Gln Pro Glu Glu Ile Pro Val Ala Met Val 
385                 390                 395                 400 


Ala Gln Arg Leu Val Gly Ile Leu Ala His Tyr Arg Glu Ser Met Leu 
                405                 410                 415     


Lys Asn Lys Asp Arg Leu Phe Arg Pro Thr His Asp Tyr Thr Gly Glu 
            420                 425                 430         


Gly Glu Pro Val Leu Glu Met Thr Ala Pro Ser Ala Lys Leu 
        435                 440                 445     


<210>  55
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 52

<400>  55

Met Ser His Gly Ala Leu His Ile Arg Asp Ser Arg Thr Ser Ala Glu 
1               5                   10                  15      


Tyr Glu Ile Pro Ile Ile Arg Asn Thr Val Leu Ala Thr Asp Leu Lys 
            20                  25                  30          


Gln Ile Lys Ala Ser Pro Val Gly Ala Asp Arg Ala Asp Lys Val Gly 
        35                  40                  45              


Asp Gly Leu Arg Val Phe Asp Pro Gly Leu Ser Asn Thr Cys Val Cys 
    50                  55                  60                  


Glu Thr Asn Met Thr Tyr Thr Asp Gly His Arg Gly Leu Leu Thr Phe 
65                  70                  75                  80  


Arg Gly Tyr Ala Leu Glu Gln Leu Trp Gln Pro Glu Phe Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Gly Lys Tyr Pro Thr Pro Ser Gln Arg Glu 
            100                 105                 110         


Thr Leu Arg Arg Thr Leu Ala Thr Leu Met Ser Pro Thr Pro Lys His 
        115                 120                 125             


Val Ala Arg Val Ile Glu Leu Phe Pro Pro Thr Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Ile Val Ala Gly Leu Ser Ala Tyr Leu Gly His His Ala Asp Ala 
145                 150                 155                 160 


Ile Ile Ala Cys Ala Gly Gly Asn Ile Tyr Asp Asn Asn Pro Glu Gln 
                165                 170                 175     


Thr Asp Arg Ala Ile Leu Arg Thr Ala Ala Ala Tyr Ala Val Val Met 
            180                 185                 190         


Gly Met Ala Ala Ser Tyr Arg Arg Gly Gly Pro Phe Val Pro Ala Asp 
        195                 200                 205             


Thr Asp Asn Thr Tyr Phe Glu Asn Leu Phe Ile Met Met Gly Leu Val 
    210                 215                 220                 


Glu Pro Tyr Thr Gly Lys Pro Asp Pro Val Lys Leu Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Ser Glu His Gly Met Ala Leu Ser Ser Phe 
                245                 250                 255     


Ala Met Val Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Gly Leu 
            260                 265                 270         


Ile Ser Ser Leu Val Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Pro 
        275                 280                 285             


Glu Ala Glu Tyr Lys Thr Ile Gln Ala Val Gly Ser Val Asp Gln Val 
    290                 295                 300                 


Pro Ala Phe Leu Asp Glu Val Lys Ser Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Thr Val Ile Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Asp Met Leu Phe Ile His Leu Asp Ala Asp Gly Asp Pro Leu Val 
            340                 345                 350         


Lys Val Ala Arg Ala Ile Asp Arg Leu Ser Ser Thr Asp Glu Tyr Phe 
        355                 360                 365             


Ile Lys Arg Lys Leu His Ala Asn Ala Asp Phe Tyr Gly Thr Phe Phe 
    370                 375                 380                 


Phe Asn Arg Leu Gly Phe Gln Pro Glu Glu Ile Pro Val Ala Met Val 
385                 390                 395                 400 


Ala Gln Arg Leu Val Gly Ile Leu Ala His Tyr Trp Glu Ser Met Leu 
                405                 410                 415     


Lys Leu Asn Ile Arg Leu Phe Arg Pro Thr His Val Tyr Thr Gly Glu 
            420                 425                 430         


Thr Glu Pro Val Leu Glu Met Thr Ala Pro Ser Ala Lys Leu 
        435                 440                 445     


<210>  56
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 52

<400>  56

Met Ser His Gly Ala Leu His Ile Ile Asp Ser Arg Thr Ser Gln Glu 
1               5                   10                  15      


Tyr Glu Ile Pro Ile Arg Glu Asn Thr Val Leu Ala Thr Asp Leu Lys 
            20                  25                  30          


Gln Ile Leu Ala Ser Pro Leu Gly Glu Asp Arg Ala Asp Gln Val Gly 
        35                  40                  45              


Asp Gly Leu Arg Val Asn Asp Pro Gly Leu Lys Asn Thr Cys Val Thr 
    50                  55                  60                  


Glu Thr Asn Met Thr Tyr Thr Asp Gly His Arg Gly Leu Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ala Leu Glu Gln Leu Trp Gln Ser Glu Phe Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Asn Gly Lys Tyr Pro Thr Pro Ser Gln Arg Glu 
            100                 105                 110         


Ser Leu Arg Ala Thr Leu Ala Val Leu Met Ser Thr Thr Pro Lys Asp 
        115                 120                 125             


Val Ala Gln Val Ile Glu Gly Phe Pro Pro Thr Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Ile Val Ala Gly Leu Ser Ala Tyr Leu Ala His His Ala Asp Ser 
145                 150                 155                 160 


Ile Pro Ala Cys Ala Gly Gly Asn Ile Tyr Asp Pro Asn Pro Glu Tyr 
                165                 170                 175     


Glu Asp Arg Ala Ile Leu Arg Thr Ala Ala Ala Tyr Ala Val Val Met 
            180                 185                 190         


Gly Met Ala Ala Ser His Ser Arg Gly Ile Ala Phe Thr Ala Ala Thr 
        195                 200                 205             


Thr Asp Asn Thr Tyr Phe Glu Asn Leu Phe Ile Met Met Gly Leu Val 
    210                 215                 220                 


Glu Cys Tyr Thr Tyr Arg Pro Asp Pro Val Lys Leu Ser Cys Phe Arg 
225                 230                 235                 240 


Met Phe Ala Ala Leu Asn Ser Glu His Gly Met Ala Leu Ser Ser Phe 
                245                 250                 255     


Ala Met Val Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Gly Leu 
            260                 265                 270         


Ile Ser Ser Leu Val Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Pro 
        275                 280                 285             


Glu Ala Glu Tyr Arg Thr Ile Leu Ala Val Gly Ser Pro Asp Gln Val 
    290                 295                 300                 


Pro Ala Phe Leu Lys Glu His Lys Ser Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Thr Thr Ile Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Asp Met Leu Leu Ser Glu Leu Asp Arg Asp Ser Glu Pro Leu Val 
            340                 345                 350         


Lys Val Ala Arg Glu Ile Asp Arg Leu Ser Pro Lys Asp Glu Tyr Phe 
        355                 360                 365             


Lys Glu Arg Lys Leu His Ala Asn Ala Asp Phe Tyr Gly Thr Phe Phe 
    370                 375                 380                 


Phe Asn Arg Leu Gly Phe Gln Gly Glu Glu Ile Pro Val Ala Met Val 
385                 390                 395                 400 


Ala Gln Arg Leu Val Gly Ile Leu Ala His Tyr Arg Glu Ser Met Leu 
                405                 410                 415     


Lys Ala Asn Asp Arg Leu Phe Arg Pro Thr His Asn Tyr Thr Gly Glu 
            420                 425                 430         


Thr Glu Pro Pro Leu Glu Met Pro Ala Pro Ser Ala Lys Leu 
        435                 440                 445     


<210>  57
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 52

<400>  57

Met Ser His Gly Ala Leu His Ile Arg Asp Ser Arg Thr Ser Lys Glu 
1               5                   10                  15      


Tyr Glu Ile Pro Ile Asp Arg Asn Thr Val Gly Ala Thr Asp Leu Lys 
            20                  25                  30          


Gln Ile Lys Ala Ser Glu Val Gly Ala Asp Arg Ala Asp Asn Val Gly 
        35                  40                  45              


Asp Gly Leu Arg Val Phe Asp Pro Gly Leu Glu Asn Thr Cys Val Val 
    50                  55                  60                  


Ser Thr Asn Met Thr Thr Thr Asp Gly His Arg Gly Asp Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ala Leu Glu Gln Leu Trp Gln Ala Glu Phe Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Gly Lys Tyr Pro Thr Pro Ser Gln Arg Glu 
            100                 105                 110         


Ala Leu Arg Leu Thr Leu Ala Thr Leu Met Ser Thr Thr Pro Lys His 
        115                 120                 125             


Val Ala Glu Val Ile Glu Thr Phe Pro Pro Thr Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Ile Val Ala Gly Leu Ser Ala Tyr Leu Ser His His Ala Asp Glu 
145                 150                 155                 160 


Ile Pro Asp Cys Arg Gly Gly Arg Ile Asp Val Leu Asn Pro Glu Gln 
                165                 170                 175     


Asn Asp His Gln Ile Leu Arg Thr Ala Ala Ala Tyr Ala Val Val Met 
            180                 185                 190         


Gly Ala Ala Ala Ser Phe Arg Arg Gly Leu Ala Phe Thr Pro Ala Asp 
        195                 200                 205             


Thr Asp Asn Thr Tyr Phe Glu Asn Leu Phe Ile Met Met Gly Gly Val 
    210                 215                 220                 


Glu Val Tyr Thr Asn Arg Pro Asp Pro Val Lys Leu Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Ser Glu His Gly Met Ala Leu Ser Ser Phe 
                245                 250                 255     


Ala Met Val Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Gly Leu 
            260                 265                 270         


Ile Ser Ser Leu Val Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Pro 
        275                 280                 285             


Glu Ala Glu Tyr Lys Thr Ile His Ala Val Gly Ser Ala Asp Gln Val 
    290                 295                 300                 


Pro Ala Phe Leu Arg Glu Val Lys Ser Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Thr Ala Ile Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Asp Met Leu Met Ser Glu Leu Glu Lys Gln Ser Asn Pro Leu Val 
            340                 345                 350         


Lys Val Ala Arg Glu Ile Asp Arg Leu Ser Ser Ser Asp Glu Tyr Phe 
        355                 360                 365             


Gly Lys Arg Lys Leu Cys Ala Asn Ala Asp Phe Tyr Gly Thr Phe Phe 
    370                 375                 380                 


Phe Asn Met Leu Gly Phe Gln Pro Glu Glu Ile Pro Val Ala Met Val 
385                 390                 395                 400 


Ala Gln Arg Leu Val Gly Ile Leu Ala His Tyr Leu Glu Ser Met Leu 
                405                 410                 415     


Ala Pro Arg Ile Arg Leu Phe Arg Pro Thr His Val Tyr Thr Gly Glu 
            420                 425                 430         


Thr Glu Pro Tyr Leu Glu Met Thr Ala Pro Ser Ala Lys Leu 
        435                 440                 445     


<210>  58
<211>  1476
<212>  DNA
<213>  Talaromyces stipitatus

<400>  58
atgactgacg agataccctt tgataaaccg atccgcgata tcgcatctta tgtacacaat       60

tacacaattc cttcatctcc aacatccttt aagcacgcgc gtggcgtgat tctcgattca      120

cttggttgcg caatagaaac attgcataga tcttcagaag catgtacatt acttggtccc      180

gtcattcccg gaacaacttt tccgtatggc tttcatcttc caggaacatc atacgttctg      240

gatccagtga agggaacatt tgatcttgga gttttgatta gatacctgga tcataatgac      300

gcttttggcg gagcggaatg gggccatcca tcagatacac tgtctgccat tattgcggta      360

atggattggt tatgtcgagc tgagcagaga agctcaacca cttccataag atacccgccg      420

ttgacaatca aaacattact agaagcagcg ataaaagcct acgaaatcca aggatgttat      480

caactccaga atgccttcaa tgcatatggt attgaccacg tgatcctggt caaacttgca      540

gctgcgtctg tatgttcatg gctgatgggc atgactgaaa cacaaacgat gtcagtcatt      600

tctcacgtgt ggatggatgg tcacccgtct cgcgtctaca gatcgggagc caacactact      660

tcgcgcaagg gctgggcagc tgctgatgcc gcgatgagag ctgttcatct ctgcttgctt      720

acgcatgctg gtcaattggg atctaaacag ccattgaatg ataagcgtta cgggttcttg      780

gtgcatacat ttggtctcga ggctggattc gcgttaccca gggcttttgg tgactgggca      840

attcagaata tctttaccaa gctaatgcct tgcgaaggac acgggatatc ggctgtcgaa      900

gcggcactag tacaaggccg gaaactcaaa tcttgcggtc atacagtgag cgatataaag      960

cacattgatc tacgtgtcac ggctgccgcg aacctaataa ttagcaaaat aggtcgatta     1020

tacaacgcag ctgatcggga ccattgcatt caatatgtga ttgcgctggc attcttgaaa     1080

ggccgctttc cagatgcaga agattatatg gatgacagcc cgtatgcaaa tagcaaggag     1140

atggatgact tacgggaaaa aattatgatg aaggtggatc aagacctaac acagggatat     1200

cttgatccgg agaggaaaag ttgcggaact ggaatgacgg tttatttgaa caatggaact     1260

gtactagacg aggttctggt tgaatatccg gctggacatt tgaagaatcc gaggacgaag     1320

gaactacacc agaggaaatt cgagaaaaac atgaggttgg catttaccga tgccgaaatt     1380

gcaaatattg tgaagtgtat tgaggatgat gagatgccta tttcgtcatt tgtggatttg     1440

tttacgaggg attcaaaggg aatggcaaaa ctatga                               1476


<210>  59
<211>  474
<212>  PRT
<213>  Talaromyces stipitatus

<400>  59

Met Thr Asp Glu Ile Pro Phe Asp Lys Pro Ile Arg Asp Ile Ala Ser 
1               5                   10                  15      


Tyr Val His Asn Tyr Thr Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Val Ile Leu Asp Ser Leu Gly Cys Ala Ile Glu Thr Leu 
        35                  40                  45              


His Arg Ser Ser Glu Ala Cys Thr Leu Leu Gly Pro Val Ile Pro Gly 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Thr Ser Tyr Val Leu 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Gly Gly Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Leu Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Lys 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Leu Gln Asn Ala Phe Asn Ala Tyr Gly Ile Asp His Val Ile Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Ile Ser Gly Ala Asn Thr Thr Ser Arg Lys Gly Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Leu Val His Thr Phe Gly Leu Glu Ala Gly Phe Ala Leu Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Ala Ile Gln Asn Ile Phe Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Leu Val Gln 
        275                 280                 285             


Gly Arg Lys Leu Lys Ser Cys Gly His Thr Val Ser Asp Ile Lys His 
    290                 295                 300                 


Ile Asp Leu Arg Val Thr Ala Ala Ala Asn Leu Ile Ile Ser Lys Ile 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Ala Ala Asp Arg Asp His Cys Ile Gln Tyr Val 
                325                 330                 335     


Ile Ala Leu Ala Phe Leu Lys Gly Arg Phe Pro Asp Ala Glu Asp Tyr 
            340                 345                 350         


Met Asp Asp Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Met Lys Val Asp Gln Asp Leu Thr Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Arg Lys Ser Cys Gly Thr Gly Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Val Leu Asp Glu Val Leu Val Glu Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Lys Glu Leu His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Leu Ala Phe Thr Asp Ala Glu Ile Ala Asn Ile Val Lys 
        435                 440                 445             


Cys Ile Glu Asp Asp Glu Met Pro Ile Ser Ser Phe Val Asp Leu Phe 
    450                 455                 460                 


Thr Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  60
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  60

Met Thr Glu Glu Ile Pro Phe Asp Lys Pro Leu Arg Glu Ile Ala Ser 
1               5                   10                  15      


Tyr Val His Asn Phe Thr Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Val Ile Leu Asp Ser Leu Gly Cys Ala Ile Glu Thr Leu 
        35                  40                  45              


His Arg Ser Ser Glu Ala Cys Thr Leu Leu Gly Pro Val Ile Pro Gly 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Thr Ser Tyr Val Leu 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Gly Ala Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Leu Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Arg 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Leu Gln Asn Ala Phe Asn Ala Tyr Gly Ile Asp His Val Ile Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Ile Ser Gly Ala Asn Thr Ser Ser Arg Lys Gly Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Met Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Leu Val His Thr Phe Gly Leu Glu Ala Gly Phe Ala Leu Pro 
                245                 250                 255     


Arg Ala Phe Gly Glu Trp Ala Ile Gln Asn Leu Phe Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Leu Val Gln 
        275                 280                 285             


Gly Arg Lys Leu Lys Ser Cys Gly His Thr Val Ser Glu Ile Lys His 
    290                 295                 300                 


Ile Glu Leu Arg Val Thr Ala Ala Ala Asn Leu Ile Ile Ser Lys Ile 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Ala Ala Asp Arg Asp His Cys Ile Gln Tyr Val 
                325                 330                 335     


Ile Ala Ile Ala Phe Val Lys Gly Arg Phe Pro Asp Ala Glu Asp Tyr 
            340                 345                 350         


Met Asp Asp Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Ile Lys Val Asp Gln Asp Leu Thr Gln Ala Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Arg Lys Ser Cys Ala Thr Gly Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Ser Val Met Asp Glu Val Leu Val Glu Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Arg Asn Pro Arg Ser Arg Glu Leu His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Leu Gly Phe Ser Asp Ala Glu Ile Ala Asn Ile Val Lys 
        435                 440                 445             


Cys Ile Glu Asp Asp Glu Met Pro Ile Ser Ser Phe Val Asp Leu Phe 
    450                 455                 460                 


Thr Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  61
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  61

Met Thr Asp Glu Ile Pro Phe Asp Lys Pro Ile Lys Asp Ile Ala Ser 
1               5                   10                  15      


Tyr Val His Asn Tyr Thr Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Val Ile Leu Asp Ser Leu Gly Cys Ala Ile Glu Thr Leu 
        35                  40                  45              


His Arg Ser Ser Glu Ala Cys Thr Leu Leu Gly Pro Val Val Pro Gly 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Thr Ser Tyr Val Val 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Gly Ala Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Leu Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Lys 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Leu Gln Asn Ala Phe Asn Ala Tyr Gly Ile Asp His Val Ile Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Ile Ser Gly Ala Asn Thr Thr Thr Arg Lys Gly Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Leu Arg Ala Val His Leu Cys Ile Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Leu Val His Thr Phe Gly Ile Glu Ala Gly Phe Ala Leu Pro 
                245                 250                 255     


Arg Gly Phe Gly Asp Trp Ala Ile Gln Asn Leu Tyr Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Leu Val Gln 
        275                 280                 285             


Gly Arg Lys Leu Lys Ser Cys Gly His Thr Leu Ser Asp Ile Lys His 
    290                 295                 300                 


Ile Asp Leu Arg Val Thr Ala Ala Ala Gln Leu Val Ile Ser Lys Ile 
305                 310                 315                 320 


Ala Arg Leu Tyr Asn Ala Ala Asp Arg Asp His Cys Ile Gln Tyr Val 
                325                 330                 335     


Ile Ala Leu Ala Phe Leu Lys Gly Arg Trp Pro Asp Ala Asp Asp Tyr 
            340                 345                 350         


Met Asp Asp Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Met Lys Val Asp Gln Asp Leu Ser Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Arg Lys Ser Cys Gly Thr Gly Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Val Leu Glu Glu Val Leu Val Glu Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Lys Asp Leu His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Ile Ala Phe Thr Asp Ala Glu Ile Ala Asn Ile Val Lys 
        435                 440                 445             


Cys Leu Glu Asp Glu Glu Met Pro Ile Thr Ser Phe Val Asp Leu Phe 
    450                 455                 460                 


Thr Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  62
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  62

Met Thr Asp Glu Ile Pro Phe Asp Lys Pro Ile Arg Asp Ile Ala Ser 
1               5                   10                  15      


Tyr Val His Asn Tyr Thr Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Val Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Leu 
        35                  40                  45              


His Arg Ser Ser Glu Ala Cys Thr Leu Leu Ala Pro Val Ile Pro Gly 
    50                  55                  60                  


Ser Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Thr Ser Tyr Val Leu 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Trp Gly Gly Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Phe Val Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Thr Ser Thr Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Lys 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Leu Gln Asn Gly Phe Asn Ala Tyr Gly Ile Asp His Val Ile Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Leu Ser Gly Ala Asn Thr Thr Ser Arg Lys Gly Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Val Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Val Val His Thr Phe Gly Leu Glu Ala Gly Phe Ala Leu Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Ala Ile Gln Asn Ile Phe Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Val Val Gln 
        275                 280                 285             


Gly Lys Lys Val Lys Ser Cys Gly His Thr Val Ser Asp Ile Lys His 
    290                 295                 300                 


Ile Asp Leu Arg Val Ser Ala Ala Gly Asn Val Ile Ile Ser Lys Leu 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Ala Ala Asp Arg Asp His Cys Ile Gln Tyr Ile 
                325                 330                 335     


Ile Ala Val Ala Phe Val Lys Gly Arg Trp Pro Asp Ala Asp Asp Tyr 
            340                 345                 350         


Met Asp Asp Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Glu Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Val Lys Val Asp Gln Asp Leu Ser Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Asp Arg Lys Ser Cys Ala Thr Ala Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Val Leu Asp Glu Val Leu Val Glu Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Lys Glu Leu His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Leu Ala Phe Thr Asp Ala Glu Ile Ala Asn Ile Leu Lys 
        435                 440                 445             


Cys Val Glu Asp Glu Asp Met Pro Ile Ser Ser Phe Val Asp Leu Phe 
    450                 455                 460                 


Ser Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  63
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  63

Met Thr Glu Glu Ile Pro Phe Asp Lys Pro Ile Lys Asp Ile Ala Ser 
1               5                   10                  15      


Tyr Val His Asn Phe Thr Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Val Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Val 
        35                  40                  45              


His Arg Ser Ser Glu Ala Cys Thr Leu Leu Gly Pro Val Val Pro Gly 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Thr Ser Tyr Val Val 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Ala Ala Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Tyr Leu Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Val Thr Ile Arg 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Val Gln Asn Ala Phe Asn Ala Tyr Gly Ile Asp His Val Ile Val 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Ile Ser Gly Ala Asn Thr Thr Ser Arg Lys Gly Phe 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Leu Val His Thr Phe Gly Leu Glu Ala Gly Trp Ala Leu Pro 
                245                 250                 255     


Lys Ala Phe Gly Asp Trp Ala Ile Gln Asn Ile Tyr Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Leu Ile Gln 
        275                 280                 285             


Gly Arg Lys Leu Lys Ser Cys Gly His Thr Val Ser Asp Ile Lys His 
    290                 295                 300                 


Ile Glu Leu Arg Val Thr Ala Ala Ala Asn Leu Leu Ile Ser Lys Ile 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Ala Ala Asp Arg Asp His Cys Ile Gln Tyr Val 
                325                 330                 335     


Ile Ala Val Ala Phe Val Lys Gly Arg Phe Pro Asp Ala Asp Asp Tyr 
            340                 345                 350         


Met Asp Glu Ser Pro Tyr Ala Gln Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Met Lys Val Asp Gln Asp Leu Thr Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Lys Lys Ser Cys Gly Thr Gly Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Val Leu Asp Glu Val Leu Val Asp Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Lys Glu Leu His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Leu Ala Trp Thr Glu Ala Glu Ile Ala Asn Ile Val Lys 
        435                 440                 445             


Cys Ile Glu Asp Asp Glu Leu Pro Val Ser Ser Phe Met Glu Leu Phe 
    450                 455                 460                 


Thr Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  64
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  64

Met Thr Asp Glu Ile Pro Phe Asp Lys Pro Val Arg Asp Ile Ala Ser 
1               5                   10                  15      


Tyr Val His Gln Tyr Thr Ile Pro Ser Ser Pro Ser Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Ser Leu Gly Cys Ala Ile Glu Thr Leu 
        35                  40                  45              


His Arg Ser Ser Glu Ala Cys Thr Leu Leu Gly Pro Leu Val Pro Ala 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Thr Ser Trp Met Val 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Gly Gly Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Leu Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Arg 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Leu Gln Asn Ala Phe Asn Gly Tyr Gly Ile Asp His Val Ile Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Ser Gln Thr Ile Ser Gly Ala Asn Thr Thr Thr Arg Lys Gly Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Leu Val His Thr Phe Gly Leu Asp Ala Gly Phe Ala Leu Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Ala Ile Gln Asn Leu Tyr Thr Lys Ile Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Ile Val Gln 
        275                 280                 285             


Gly Arg Lys Met Lys Thr Cys Gly His Thr Leu Ser Glu Ile Lys His 
    290                 295                 300                 


Ile Asp Leu Arg Val Thr Ala Ala Ala Asn Leu Leu Ile Ser Lys Ile 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Gly Ala Asp Arg Asp His Cys Ile Gln Tyr Met 
                325                 330                 335     


Ile Ala Leu Ala Phe Leu Lys Gly Arg Phe Pro Asp Ala Asp Asp Tyr 
            340                 345                 350         


Met Asp Asp Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Leu Lys Val Asp Gln Glu Leu Thr Gln Ala Tyr Leu 
    370                 375                 380                 


Asp Pro Asp Lys Lys Thr Cys Gly Thr Gly Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Val Ile Glu Glu Val Leu Val Glu Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Arg Asp Leu His Gln Arg Lys Phe Asp Arg 
            420                 425                 430         


Asn Met Arg Leu Ala Phe Thr Asp Ala Glu Ile Ala Asn Ile Met Lys 
        435                 440                 445             


Cys Leu Asp Asp Asp Asp Leu Pro Val Ser Ser Phe Val Glu Leu Tyr 
    450                 455                 460                 


Thr Arg Glu Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  65
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  65

Met Thr Glu Glu Ile Pro Phe Asp Lys Pro Leu Arg Asp Ile Ala Thr 
1               5                   10                  15      


Trp Val His Asn Phe Thr Leu Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Leu 
        35                  40                  45              


His Arg Ser Ser Glu Gly Cys Thr Val Leu Gly Pro Ile Val Pro Gly 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Ala Phe His Leu Pro Gly Thr Ser Phe Val Leu 
65                  70                  75                  80  


Asp Pro Leu Lys Gly Thr Phe Asp Leu Gly Val Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Gly Gly Ala Glu Phe Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Leu Cys Arg Ala Glu 
        115                 120                 125             


Asn Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Arg 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Val Gln Asn Ala Phe Asn Ala Tyr Gly Leu Asp His Val Leu Val 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Val Ser Gly Ala Asn Thr Thr Thr Arg Lys Gly Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Ile Val His Thr Phe Gly Leu Glu Ala Gly Trp Ala Leu Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Ala Ile Gln Gln Val Phe Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Leu Val Gln 
        275                 280                 285             


Gly Arg Lys Leu Lys Ser Cys Gly His Thr Leu Ser Asp Ile Lys His 
    290                 295                 300                 


Ile Glu Leu Arg Val Thr Ala Ala Gly Asn Leu Ile Ile Thr Lys Ile 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Ala Ala Asp Arg Asp His Cys Ile Gln Tyr Val 
                325                 330                 335     


Ile Ala Leu Ala Phe Val Lys Gly Arg Phe Pro Asp Ala Glu Glu Tyr 
            340                 345                 350         


Met Asp Asp Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Asp Lys Ile Met Val Lys Leu Asp Gln Glu Leu Thr Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Arg Lys Ser Cys Gly Thr Gly Met Thr Val Trp Leu Asn 
385                 390                 395                 400 


Asn Gly Ser Val Leu Asp Glu Val Leu Val Glu Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Lys Glu Leu His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Leu Ala Phe Thr Asp Ala Glu Ile Ala Asn Ile Met Lys 
        435                 440                 445             


Cys Leu Glu Asp Glu Asp Ile Pro Ile Thr Ser Phe Leu Asp Leu Phe 
    450                 455                 460                 


Thr Arg Glu Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  66
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  66

Met Thr Asp Glu Ile Pro Phe Asp Lys Pro Ile Arg Asp Ile Ala Ser 
1               5                   10                  15      


Phe Val His Asn Tyr Thr Val Pro Thr Ser Pro Thr Ser Tyr Arg His 
            20                  25                  30          


Ala Arg Ala Val Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Val 
        35                  40                  45              


His Arg Thr Ser Glu Gly Cys Thr Val Met Gly Pro Val Val Pro Ala 
    50                  55                  60                  


Thr Thr Phe Pro Tyr Gly Phe His Leu Pro Gly Ser Thr Tyr Val Met 
65                  70                  75                  80  


Asp Pro Leu Arg Gly Thr Phe Asp Leu Gly Ile Leu Ile Arg Trp Leu 
                85                  90                  95      


Asp His Asn Asp Gly Tyr Ala Ala Ala Glu Phe Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Leu Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Ile Thr Ile Lys 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Ala Cys Tyr 
145                 150                 155                 160 


Gln Leu Gln Asn Ala Phe Asn Ala Phe Gly Ile Asp His Val Ile Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Val Ser Gly Ala Asn Thr Thr Ser Arg Lys Ala Trp 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Met Gly Ser Arg Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Val Val His Thr Phe Ala Leu Glu Ala Gly Phe Ala Ile Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Ala Ile Gln Asn Ile Phe Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Ser Ala Val Glu Ala Ala Leu Val Gln 
        275                 280                 285             


Gly Arg Lys Leu Lys Ser Cys Gly His Ser Leu Ser Glu Ile Lys His 
    290                 295                 300                 


Ile Glu Leu Arg Val Ser Ala Ala Ala Asn Leu Leu Met Ser Lys Ile 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Ala Ala Glu Arg Asp His Cys Ile Gln Tyr Val 
                325                 330                 335     


Ile Ala Ile Ala Phe Val Lys Gly Arg Phe Pro Asp Ala Asp Glu Tyr 
            340                 345                 350         


Met Asp Glu Ser Pro Tyr Ala Asn Ser Lys Glu Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Leu Lys Val Asp Gln Glu Ile Thr Gln Ala Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Lys Lys Ser Cys Gly Thr Gly Met Ser Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Ser Val Leu Glu Asp Val Ile Val Glu Phe Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Ser Lys Asp Leu His Gln Arg Lys Phe Glu Arg 
            420                 425                 430         


Asn Leu Arg Leu Gly Phe Ser Glu Ala Glu Ile Ala Asn Ile Ile Lys 
        435                 440                 445             


Cys Ile Glu Glu Asp Glu Met Pro Leu Ser Ser Phe Leu Glu Leu Phe 
    450                 455                 460                 


Thr Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  67
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  67

Met Thr Glu Glu Ile Pro Phe Asp Lys Pro Ile Arg Asp Ile Ala Ser 
1               5                   10                  15      


Phe Val His Asn Tyr Ser Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Arg Gly Ile Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Val 
        35                  40                  45              


His Arg Ser Ser Asp Ala Cys Thr Ile Val Gly Pro Met Val Pro Gly 
    50                  55                  60                  


Thr Ser Phe Pro Tyr Gly Phe His Leu Pro Gly Ser Ser Tyr Val Val 
65                  70                  75                  80  


Asp Pro Val Lys Gly Thr Phe Asp Leu Gly Ile Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Gly Ala Ala Glu Trp Gly His Pro Ser Asp 
            100                 105                 110         


Ser Leu Ser Ala Ile Ile Ala Val Met Asp Phe Val Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Ser Thr Ser Ile Arg Tyr Pro Pro Leu Thr Ile Lys 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Gly Cys Tyr 
145                 150                 155                 160 


Gln Met Gln Asn Ala Phe Asn Ala Tyr Gly Ile Asp His Val Leu Met 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Ile Ser Gly Ala Asn Thr Thr Ser Arg Lys Ala Phe 
        195                 200                 205             


Ala Ala Ala Glu Ala Ala Met Arg Ala Val His Leu Cys Leu Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Ile Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Tyr 
225                 230                 235                 240 


Gly Phe Ile Val His Thr Phe Gly Leu Glu Gly Gly Phe Ala Val Pro 
                245                 250                 255     


Arg Gly Phe Gly Asp Trp Ala Ile Gln Asn Met Phe Thr Lys Val Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Thr Ala Val Glu Ala Ala Val Leu Gln 
        275                 280                 285             


Gly Arg Lys Val Arg Ser Cys Ala His Ser Leu Ser Asp Ile Arg His 
    290                 295                 300                 


Ile Asp Leu Arg Val Ser Ala Gly Ala Asn Leu Ile Ile Ser Lys Met 
305                 310                 315                 320 


Gly Arg Val Tyr Asn Gly Ala Asp Arg Asp His Cys Ile Gln Tyr Ile 
                325                 330                 335     


Ile Ala Ile Ala Phe Leu Lys Gly Arg Phe Pro Asp Ala Glu Asp Tyr 
            340                 345                 350         


Met Glu Asp Ser Pro Tyr Ala Asn Ser Lys Asp Met Asp Glu Leu Arg 
        355                 360                 365             


Glu Lys Ile Val Val Arg Val Asp Gln Glu Leu Ser Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Lys Lys Ser Cys Gly Thr Gly Met Thr Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Ile Val Asp Glu Val Leu Leu Asp Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Lys Asn Pro Arg Thr Arg Asp Val His Gln Arg Lys Phe Glu Lys 
            420                 425                 430         


Asn Met Arg Leu Ala Phe Thr Asp Ala Glu Ile Ala Gln Ile Ile Lys 
        435                 440                 445             


Cys Ile Glu Asp Glu Asp Met Pro Val Ser Ser Phe Ile Glu Leu Phe 
    450                 455                 460                 


Thr Arg Asp Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  68
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  68

Met Thr Glu Glu Ile Pro Phe Asp Lys Pro Leu Arg Asp Ile Ala Ser 
1               5                   10                  15      


Phe Val His Asn Tyr Thr Ile Pro Ser Ser Pro Thr Ser Phe Lys His 
            20                  25                  30          


Ala Lys Gly Leu Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Val 
        35                  40                  45              


His Lys Thr Ser Glu Ala Cys Thr Val Val Gly Pro Ile Ile Pro Ala 
    50                  55                  60                  


Thr Ser Phe Pro Tyr Gly Phe His Leu Pro Gly Ser Ser Tyr Val Val 
65                  70                  75                  80  


Asp Pro Met Lys Gly Thr Phe Asp Leu Gly Met Leu Ile Arg Tyr Leu 
                85                  90                  95      


Asp His Asn Asp Ala Tyr Gly Ala Ala Glu Tyr Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Trp Ile Cys Arg Gly Glu 
        115                 120                 125             


Asn Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Val Thr Ile Arg 
    130                 135                 140                 


Thr Leu Leu Glu Ala Ala Ile Lys Ala Tyr Glu Ile Gln Ala Cys Tyr 
145                 150                 155                 160 


Gln Ile Asn Asn Ala Phe Asn Gly Tyr Gly Ile Asp His Val Ile Val 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Glu Thr Gln Thr Val Ser Gly Ala Asn Ser Thr Thr Arg Lys Gly Phe 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Val Leu Thr 
    210                 215                 220                 


His Ala Gly Gln Ile Gly Ser Arg Asn Pro Leu Asn Asp Lys Lys Tyr 
225                 230                 235                 240 


Gly Phe Leu Val His Thr Phe Gly Leu Glu Ala Gly Phe Ala Ile Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Gly Ile Gln Gln Leu Tyr Thr Lys Leu Met 
            260                 265                 270         


Pro Cys Glu Ala His Gly Ile Thr Ala Val Glu Ala Ala Ile Val Gln 
        275                 280                 285             


Gly Lys Lys Val Lys Ser Cys Ala His Thr Val Thr Asp Ile Lys His 
    290                 295                 300                 


Ile Glu Leu Lys Val Ser Gly Ala Ala Asn Val Leu Leu Ser Arg Val 
305                 310                 315                 320 


Gly Arg Leu Tyr Asn Gly Ala Asp Arg Asp His Cys Ile Gln Tyr Ile 
                325                 330                 335     


Ile Ala Ile Ala Phe Met Arg Gly Arg Phe Pro Asp Ala Asp Glu Tyr 
            340                 345                 350         


Met Glu Glu Ser Pro Tyr Ala Asn Ser Lys Asp Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Ile Val Lys Leu Asp Gln Glu Leu Thr Gln Gly Tyr Leu 
    370                 375                 380                 


Asp Pro Glu Lys Lys Thr Cys Ala Thr Ala Met Ser Val Tyr Leu Asn 
385                 390                 395                 400 


Asn Gly Thr Val Leu Glu Glu Val Val Val Asp Tyr Pro Ala Gly His 
                405                 410                 415     


Val Lys Asn Pro Arg Ser Arg Glu Leu His Gln Arg Lys Phe Glu Arg 
            420                 425                 430         


Asn Leu Arg Leu Gly Phe Thr Glu Ala Glu Ile Ala Asn Ile Val Lys 
        435                 440                 445             


Cys Val Glu Asp Asp Glu Met Pro Ile Ser Ser Phe Met Glu Leu Phe 
    450                 455                 460                 


Thr Lys Glu Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  69
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 59

<400>  69

Met Thr Asp Glu Ile Pro Trp Asp Lys Pro Met Arg Asp Ile Ala Thr 
1               5                   10                  15      


Tyr Val His Asn Phe Thr Ile Pro Ser Ser Pro Thr Ser Phe Arg His 
            20                  25                  30          


Ala Lys Gly Leu Ile Leu Asp Thr Leu Gly Cys Ala Ile Glu Thr Ile 
        35                  40                  45              


His Arg Thr Ser Glu Gly Cys Ser Met Leu Gly Pro Leu Leu Pro Gly 
    50                  55                  60                  


Thr Ser Phe Pro Tyr Ala Phe His Leu Pro Gly Thr Ser Tyr Val Ile 
65                  70                  75                  80  


Asp Pro Leu Lys Gly Thr Phe Asp Leu Gly Ile Leu Ile Arg Trp Leu 
                85                  90                  95      


Asp His Asn Asp Ala Phe Ala Ala Ala Glu Tyr Gly His Pro Ser Asp 
            100                 105                 110         


Thr Leu Ser Ala Ile Ile Ala Val Met Asp Tyr Val Cys Arg Ala Glu 
        115                 120                 125             


Gln Arg Ser Ser Thr Thr Ser Ile Arg Tyr Pro Pro Met Thr Ile Arg 
    130                 135                 140                 


Thr Leu Leu Asp Ala Ala Ile Arg Ala Tyr Glu Ile Gln Ala Cys Tyr 
145                 150                 155                 160 


Gln Ile Gln Asn Ala Trp Asn Ala Tyr Gly Ile Asp His Val Val Leu 
                165                 170                 175     


Val Lys Leu Ala Ala Ala Ser Val Cys Ser Trp Leu Met Gly Met Thr 
            180                 185                 190         


Asp Ser Gln Thr Met Ser Gly Ala Asn Thr Thr Thr Arg Lys Ala Phe 
        195                 200                 205             


Ala Ala Ala Asp Ala Ala Met Arg Ala Val His Leu Cys Met Leu Thr 
    210                 215                 220                 


His Gly Gly Gln Leu Gly Ser Lys Gln Pro Leu Asn Asp Lys Arg Trp 
225                 230                 235                 240 


Gly Phe Leu Val His Ser Phe Gly Leu Glu Ala Gly Phe Ala Ile Pro 
                245                 250                 255     


Arg Ala Phe Gly Asp Trp Ala Ile Gln Asn Ile Tyr Thr Lys Ile Met 
            260                 265                 270         


Pro Cys Glu Gly His Gly Ile Thr Ala Val Glu Ala Ala Met Val Gln 
        275                 280                 285             


Gly Arg Arg Leu Lys Ser Cys Gly His Ser Val Thr Glu Ile Lys His 
    290                 295                 300                 


Ile Asp Leu Arg Val Ser Ala Gly Ala Gln Leu Ile Ile Ser Lys Ile 
305                 310                 315                 320 


Ala Arg Ile Tyr Asn Gly Ala Asp Arg Asp His Cys Ile Gln Tyr Ile 
                325                 330                 335     


Ile Ala Val Ala Phe Val Lys Gly Arg Phe Pro Glu Ala Asp Asp Tyr 
            340                 345                 350         


Met Glu Glu Ser Pro Phe Ala Asn Ser Lys Asp Met Asp Asp Leu Arg 
        355                 360                 365             


Glu Lys Ile Met Val Lys Ile Asp Gln Glu Leu Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Pro Glu Arg Lys Ser Cys Gly Ser Gly Met Ser Val Tyr Leu Gln 
385                 390                 395                 400 


Asn Gly Thr Val Leu Glu Glu Val Leu Leu Asp Tyr Pro Ala Gly His 
                405                 410                 415     


Leu Arg Asn Pro Arg Ser Arg Glu Leu His Gln Arg Lys Phe Glu Arg 
            420                 425                 430         


Asn Leu Arg Leu Ala Phe Ser Glu Gly Glu Val Ala Asn Ile Leu Lys 
        435                 440                 445             


Cys Val Glu Asp Glu Glu Met Pro Val Ser Ser Phe Val Glu Leu Phe 
    450                 455                 460                 


Thr Arg Glu Ser Lys Gly Met Ala Lys Leu 
465                 470                 


<210>  70
<211>  1530
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  70
atgcaagcgt acgaccaggt cattgtggat atcaaagact atgtcttcca ctatgatatc       60

cactccccgc aggcatggac caccgcccgc gtggctcttc tggatgccat gggctgtgcc      120

atcgagactg tcgctctgag tgccgattgt aggcgattct ttggccccat cgttcccgac      180

acggtgactc cctatggctt ccacatgccc gggacctcct atgtcttgga ccccttgaaa      240

ggctcgttcg acatggccac ggcggtgcga tatctggacc ataatgatgc catcgcgggg      300

gcagactggg gacatccgtc gggtatactc tttccatttc ttcttttcga aacaaagaag      360

ccgaggacag tcgctgacat ggtccgggca gataatctcg gggcgatcct ggccgtcagt      420

gactggctgt gtcgatccgt cgccagctgc cgcatcgtgc acactgggcc cccattgacg      480

atgcgtacat tgctgacggc gctgatcaag gcctatgaaa tccaggggtg catgctgctc      540

cagaatgcct ttcattcaca cggtctggac catgtcgtgc tggtcaagct ggcctcgacg      600

gccgtcgtgg catggctcct tggcctgtcc gagacgcaga cgatggcggc tatctcgcag      660

gtctggatgg acggtcatcc cctgcgcgtc tatcgctctg gcagtaatac catcccgcgc      720

aagggctggg ccgccggtga tgcctgtatg aaggccacgc atctggcctt gctgactcgc      780

gcgggacaac cgggctcccc gaccccgttg acgatgcccc ggtggggatt ctatgccacc      840

tcgttcggaa ataagacctt cgacctgccg cagccatacg gcagttgggt gatggagaac      900

atcattttca aggtcatgcc cgtcgagggc cacgcactgt cgtcggtcga ggcggcgctc      960

cgtcatcggg cagcgatgca ggcgcgaggc atgaagcatc ccgagaagga tattgactgt     1020

atcgagatca ggaccaatgc cgcggccgac atgatcatca acaaacgggg cccgctgtcc     1080

aacgccgcgg accgggatca ttgtctgcag tacatcgtga gcctggcgtt cctcaagggg     1140

gcgatgcccg aagtccgtga ctaccaggat gacagtgtct ggtcgtcaag ccgagccatc     1200

actgcactgc gcgagaagat ccagattcaa ccagatgagc aactgacgcg cgattatctg     1260

gatctcgacg tgaagagtct ggcgtcggga atgacggtgc gcctgatcga tggcacggtg     1320

ctcgacgaga ttctggtcca cttcccagtc gggcacagca agcatccgca gacgttcacg     1380

acggtccgtg aaaaggtccg gaggaatctg agtctgatgt tttccacgga agaaatctcg     1440

cggatggagg cggcggtgga ggaggagtct ctggggattt ctgggtttgt ggatctcttt     1500

gtccgtcccc ggtctgaagt gaagctttaa                                      1530


<210>  71
<211>  486
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  71

Met Gln Ala Tyr Asp Gln Val Ile Val Asp Ile Lys Asp Tyr Val Phe 
1               5                   10                  15      


His Tyr Asp Ile His Ser Pro Gln Ala Trp Thr Thr Ala Arg Val Ala 
            20                  25                  30          


Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Val Ala Leu Ser Ala 
        35                  40                  45              


Asp Cys Arg Arg Phe Phe Gly Pro Ile Val Pro Asp Thr Val Thr Pro 
    50                  55                  60                  


Tyr Gly Phe His Met Pro Gly Thr Ser Tyr Val Leu Asp Pro Leu Lys 
65                  70                  75                  80  


Gly Ser Phe Asp Met Ala Thr Ala Val Arg Tyr Leu Asp His Asn Asp 
                85                  90                  95      


Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu Gly Ala 
            100                 105                 110         


Ile Leu Ala Val Ser Asp Trp Leu Cys Arg Ser Val Ala Ser Cys Arg 
        115                 120                 125             


Ile Val His Thr Gly Pro Pro Leu Thr Met Arg Thr Leu Leu Thr Ala 
    130                 135                 140                 


Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Met Leu Leu Gln Asn Ala 
145                 150                 155                 160 


Phe His Ser His Gly Leu Asp His Val Val Leu Val Lys Leu Ala Ser 
                165                 170                 175     


Thr Ala Val Val Ala Trp Leu Leu Gly Leu Ser Glu Thr Gln Thr Met 
            180                 185                 190         


Ala Ala Ile Ser Gln Val Trp Met Asp Gly His Pro Leu Arg Val Tyr 
        195                 200                 205             


Arg Ser Gly Ser Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala Gly Asp 
    210                 215                 220                 


Ala Cys Met Lys Ala Thr His Leu Ala Leu Leu Thr Arg Ala Gly Gln 
225                 230                 235                 240 


Pro Gly Ser Pro Thr Pro Leu Thr Met Pro Arg Trp Gly Phe Tyr Ala 
                245                 250                 255     


Thr Ser Phe Gly Asn Lys Thr Phe Asp Leu Pro Gln Pro Tyr Gly Ser 
            260                 265                 270         


Trp Val Met Glu Asn Ile Ile Phe Lys Val Met Pro Val Glu Gly His 
        275                 280                 285             


Ala Leu Ser Ser Val Glu Ala Ala Leu Arg His Arg Ala Ala Met Gln 
    290                 295                 300                 


Ala Arg Gly Met Lys His Pro Glu Lys Asp Ile Asp Cys Ile Glu Ile 
305                 310                 315                 320 


Arg Thr Asn Ala Ala Ala Asp Met Ile Ile Asn Lys Arg Gly Pro Leu 
                325                 330                 335     


Ser Asn Ala Ala Asp Arg Asp His Cys Leu Gln Tyr Ile Val Ser Leu 
            340                 345                 350         


Ala Phe Leu Lys Gly Ala Met Pro Glu Val Arg Asp Tyr Gln Asp Asp 
        355                 360                 365             


Ser Val Trp Ser Ser Ser Arg Ala Ile Thr Ala Leu Arg Glu Lys Ile 
    370                 375                 380                 


Gln Ile Gln Pro Asp Glu Gln Leu Thr Arg Asp Tyr Leu Asp Leu Asp 
385                 390                 395                 400 


Val Lys Ser Leu Ala Ser Gly Met Thr Val Arg Leu Ile Asp Gly Thr 
                405                 410                 415     


Val Leu Asp Glu Ile Leu Val His Phe Pro Val Gly His Ser Lys His 
            420                 425                 430         


Pro Gln Thr Phe Thr Thr Val Arg Glu Lys Val Arg Arg Asn Leu Ser 
        435                 440                 445             


Leu Met Phe Ser Thr Glu Glu Ile Ser Arg Met Glu Ala Ala Val Glu 
    450                 455                 460                 


Glu Glu Ser Leu Gly Ile Ser Gly Phe Val Asp Leu Phe Val Arg Pro 
465                 470                 475                 480 


Arg Ser Glu Val Lys Leu 
                485     


<210>  72
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 71

<400>  72

Met Gln Ala Tyr Asp Asp Val Ile Val Asp Ile Lys Asp Tyr Val Phe 
1               5                   10                  15      


His Tyr Asp Ile Asp Ser Pro Gln Ala Trp Thr Thr Ala Arg Ser Ala 
            20                  25                  30          


Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Val Ala Asp Ser Ala 
        35                  40                  45              


Asp Cys Gly Arg Phe Phe Gly Pro Ile Val Pro Asp Thr Val Thr Pro 
    50                  55                  60                  


Tyr Gly Phe His Met Pro Gly Thr Gly Tyr Val Leu Asp Pro Leu Lys 
65                  70                  75                  80  


Gly Ser Phe Asp Met Ala Thr Ala Val Arg Tyr Leu Asp His Asn Asp 
                85                  90                  95      


Ala Ile Ala Gly Ala Asp Ile Gly His Pro Ser Asp Asn Leu Gly Ala 
            100                 105                 110         


Ile Leu Ala Val Ser Asp Trp Leu Cys Arg Ser Val Ala Ser Cys Arg 
        115                 120                 125             


Ile Val His Thr Gly Pro Pro Leu Thr Met Arg Thr Leu Leu Thr Ala 
    130                 135                 140                 


Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Met Leu Leu Gln Asn Ala 
145                 150                 155                 160 


Phe His Ser His Gly Leu Asp His Val Val Leu Val Lys Leu Ala Ser 
                165                 170                 175     


Thr Ala Val Val Ala Trp Leu Leu Gly Leu Ser Glu Thr Gln Thr Met 
            180                 185                 190         


Ala Ala Ile Ser Gln Val Trp Met Asp Gly His Pro Leu Arg Val Tyr 
        195                 200                 205             


Arg Leu Gly Ser Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala Gly Asp 
    210                 215                 220                 


Ala Cys Met Lys Ala Thr His Leu Ala Leu Leu Thr Leu Ala Gly Gln 
225                 230                 235                 240 


Pro Gly Ser Pro Thr Pro Leu Thr Met Pro Glu Trp Gly Phe Tyr Ala 
                245                 250                 255     


Met Ser Phe Gly Asn Lys Thr Phe Asn Leu Ser Gln Pro Tyr Gly Ser 
            260                 265                 270         


Trp Val Met Glu Asn Ile Ile Phe Lys Val Met Pro Val Glu Gly His 
        275                 280                 285             


Ala Leu Ser Ser Val Glu Ala Ala Arg Ala His Arg Ala Ala Met Gln 
    290                 295                 300                 


Ala Arg Gly Met Lys His Pro Glu Lys Asp Ile Asp Cys Ile Glu Ile 
305                 310                 315                 320 


Arg Thr Asn Ala Ala Ala Asp Met Ile Ile Asn Lys Arg Gly Pro Tyr 
                325                 330                 335     


Ser Asn Ala Ala Asp Arg Asp His Cys Leu Gln Tyr Ile Val Ser Leu 
            340                 345                 350         


Ala Phe Leu Lys Gly Ala Met Pro Glu Val Arg Asp Tyr Gln Asp Asp 
        355                 360                 365             


Ser Val Trp Ser Ser Ser Arg Ala Ile Thr Ala Leu Arg Glu Lys Ile 
    370                 375                 380                 


Gln Ile Gln Pro Asp Glu Gln Leu Thr Thr Pro Tyr Leu Asp Leu Ala 
385                 390                 395                 400 


Val Lys Ser Leu Ala Ser Gly Met Thr Val Arg Leu Ile Asp Gly Thr 
                405                 410                 415     


Val Leu Asp Glu Ile Leu Val His Ala Pro Val Gly His Ser Lys His 
            420                 425                 430         


Pro Gln Thr Phe Thr Thr Val Arg Glu Lys Val Arg Lys Asn Leu Ser 
        435                 440                 445             


Leu Met Phe Ser Gln Glu Glu Ile Ser Arg Met Glu Ala Ala Leu Glu 
    450                 455                 460                 


Glu Glu Ser Leu Gly Ile Ser Glu Phe Thr Asp Leu Phe Val Arg Pro 
465                 470                 475                 480 


Arg Ser Glu Val Lys Leu 
                485     


<210>  73
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 71

<400>  73

Met Gln Ala Tyr Asp Gln Val Ile Val Asp Ile Lys Asp Tyr Val Phe 
1               5                   10                  15      


His Tyr Asp Trp His Ser Pro Gln Ala Val Thr Thr Ala Arg Val Ala 
            20                  25                  30          


Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Val Ala Leu Ser Ala 
        35                  40                  45              


Asp Cys Arg Asn Phe Phe Gln Pro Ile Val Glu Asp Thr Val Thr Pro 
    50                  55                  60                  


Tyr Gly Phe His Met Pro Gly Gly Gln Tyr Val Leu Asp Pro Leu Leu 
65                  70                  75                  80  


Gly Ser Phe Asp Met Ala Thr Ala Val Arg Tyr Leu Asp His Asn Asp 
                85                  90                  95      


Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu Gly Ala 
            100                 105                 110         


Ile Leu Ala Val Ser Asp Trp Leu Cys Arg Ser Val Ala Ser Cys Arg 
        115                 120                 125             


Ile Val His Thr Thr Pro Pro Leu Thr Met Arg Thr Leu Leu Thr Ala 
    130                 135                 140                 


Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Met Leu Leu Gln Asn Ala 
145                 150                 155                 160 


Phe His Ser Arg Gly Leu Asp His Val Val Leu Val Lys Leu Ala Ser 
                165                 170                 175     


Thr Ala Val Val Ala Trp Leu Leu Gly Leu Ser Glu Thr Gln Thr Met 
            180                 185                 190         


Ala Ala Ile Ser Gln Val Trp Met Asp Gly His Pro Leu Arg Val Tyr 
        195                 200                 205             


Arg Ser Gly Ser Asn Thr Ile Pro Ile Lys Ser Trp Ala Ala Gly Trp 
    210                 215                 220                 


Ala Cys Met Lys Ala Thr Glu Leu Ala Leu Leu Thr Arg Ala Gly Gln 
225                 230                 235                 240 


Pro Gly Ser Pro Thr Pro Leu Thr Met Pro Arg Trp Gly Phe Tyr Ala 
                245                 250                 255     


Thr Ser Phe Gly Asn Lys Thr Phe Asp Leu Pro Gln Arg Tyr Gly Ser 
            260                 265                 270         


Trp Val Met Glu Asn Ile Ile Phe Lys Val Met Pro Val Glu Gly His 
        275                 280                 285             


Ala Leu Ser Ser Val Glu Ala Ala Leu Arg His Arg Ala Ala Met Gln 
    290                 295                 300                 


Ala Lys Gly Met Lys His Pro Glu Lys Asp Ile Asp Cys Ile Glu Ile 
305                 310                 315                 320 


Arg Thr Asn Gln Ala Ala Asp Met Ile Ile Asn Asn Arg Gly Pro Leu 
                325                 330                 335     


Ser Asn Ala Ala Asp Arg Asp His Cys Leu Gln Tyr Ile Val Ser Leu 
            340                 345                 350         


Ala Phe Leu Lys Gly Ala Met Pro Ser Val Arg Asp Tyr Gln Asp Asp 
        355                 360                 365             


Ser Val Trp Ser Ser Ser Arg Ala Ile Thr Ala Leu Arg Ala Lys Ile 
    370                 375                 380                 


Gln Ile Gln Pro Asp Glu Glu Leu Thr Arg Asp Tyr Leu Asp Leu Asp 
385                 390                 395                 400 


Val Lys Ser Leu Ala Ser Gly Met Thr Val Arg Leu Ile Asp Gly Thr 
                405                 410                 415     


Val Leu Thr Glu Ile Leu Val His Phe Pro Val Gly His Ser Lys His 
            420                 425                 430         


Pro Gln Thr Phe Thr Thr Val Arg Glu Lys Val Arg Arg Asn Leu Ser 
        435                 440                 445             


Leu Met Phe Ser Thr Glu Glu Ile Ser Arg Met Glu Ala Ala Val Glu 
    450                 455                 460                 


Ala Glu Ser Leu Gly Ile Pro Gly Phe Val Asp Leu Phe Ile Arg Pro 
465                 470                 475                 480 


Arg Ser Glu Val Lys Leu 
                485     


<210>  74
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 71

<400>  74

Met Gln Ala Tyr Asp Gln Val Ile Val Asp Ile Lys Asp Tyr Val Thr 
1               5                   10                  15      


His Tyr Asp Ile His Ser Pro Gln Ala Trp Thr Lys Ala Arg Val Ala 
            20                  25                  30          


Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Val Ala Leu Ser Ala 
        35                  40                  45              


Asp Cys Arg Arg Val Phe Arg Asn Ile Val Pro Asp Thr Val Val Pro 
    50                  55                  60                  


Tyr Gly Phe His Met Pro Gly Thr Ser Tyr Val Leu Asp Pro Val Lys 
65                  70                  75                  80  


Gly Ser Phe Asp Met Ala Thr Ala Val Arg Tyr Leu Asp His Asn Asp 
                85                  90                  95      


Ala Ile Arg Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu Gly Ala 
            100                 105                 110         


Ile Leu Ala Val Ser Asp Trp Leu Cys Arg Ser Val Ala Ser Cys Arg 
        115                 120                 125             


Ile Val His Thr Arg Pro Pro Leu Thr Met Arg Thr Leu Leu Ala Ala 
    130                 135                 140                 


Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Met Leu Leu Gln Ala Ala 
145                 150                 155                 160 


Phe Tyr Ser His Gly Leu Asp His Val Val Leu Val Lys Leu Ala Ser 
                165                 170                 175     


Thr Ala Val Val Ala Trp Leu Leu Gly Leu Ser Glu Thr Gln Thr Met 
            180                 185                 190         


Ala Ala Ile Ser Gln Val Trp Met Asp Gly His Pro Leu Arg Val Tyr 
        195                 200                 205             


Arg Ser Gly Ser Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala Gly Asp 
    210                 215                 220                 


Ala Cys Met Lys Ala Thr His Leu Ala Leu Leu Thr Arg Ala Gly Gln 
225                 230                 235                 240 


Pro Gly Tyr Pro Thr Pro Leu Thr Met Pro Glu Trp Gly Phe Ala Ala 
                245                 250                 255     


Thr Ser Phe Gly Asn Lys Thr Phe Asp Leu Pro Ser Pro Tyr Gly Ser 
            260                 265                 270         


Trp Val Met Glu Asn Ile Gly Phe Lys Val Met Pro Val Glu Gly His 
        275                 280                 285             


Ala Leu Ser Ser Val Glu Ala Ala Leu Arg His Arg Arg Ala Met Gln 
    290                 295                 300                 


Ala His Gly Met Lys His Pro Glu Lys Asp Ile Asp Cys Ile Glu Ile 
305                 310                 315                 320 


Arg Thr Asn Gln Ala Ala Val Arg Ile Ile Asn Lys Arg Gly Pro Leu 
                325                 330                 335     


Ser Asn Ala Ala Asp Arg Asp His Cys Leu Gln Tyr Ile Val Ser Leu 
            340                 345                 350         


Ala Phe Leu Lys Gly Ala Met Pro Glu Val Arg Asp Tyr Gln Asp Asp 
        355                 360                 365             


Ser Val Ala Ser Ser Ser Arg Ala Ile Lys Ala Leu Arg Glu Lys Ile 
    370                 375                 380                 


Gln Ile Glu Pro Asp Glu Ala Leu Thr Arg Asp Tyr Leu Asp Leu Asp 
385                 390                 395                 400 


Val Lys Ser Ile Ala Ser Gly Met Thr Val Arg Leu Ile Asp Gly Thr 
                405                 410                 415     


Val Leu Asp Lys Ile Leu Val His Phe Pro Val Gly His Ser Lys His 
            420                 425                 430         


Pro Gln Thr Trp Thr Thr Val Arg Glu Lys Val Arg Arg Asn Leu Ser 
        435                 440                 445             


Leu Met Phe Ser Thr Glu Glu Ile Ser Pro Met Glu Ala Thr Val Glu 
    450                 455                 460                 


Glu Glu Ser Arg Gly Ile Ser Glu Phe Met Thr Leu Phe Val Arg Pro 
465                 470                 475                 480 


Arg Ser Glu Val Lys Leu 
                485     


<210>  75
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 71

<400>  75

Met Gln Asp Tyr Asp Gln Val Ile Val Gln Ile Lys Asp Tyr Val Arg 
1               5                   10                  15      


His Lys Lys Ile His Ser Pro Gln Ala Trp Val Thr Ala Arg Val Ala 
            20                  25                  30          


Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Val Ala Leu Ser Ala 
        35                  40                  45              


Asp Cys Arg Arg Phe Phe Gly Pro Ile Val Pro Asp Thr Tyr Thr Pro 
    50                  55                  60                  


Tyr Gly Phe His Met Pro Gly Thr Ser Tyr Gln Leu Asp Pro Leu Lys 
65                  70                  75                  80  


Gly Ser Phe Asp Met Ala Thr Ala Val Arg Tyr Leu Asp His Asn Asp 
                85                  90                  95      


Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu Gly Ala 
            100                 105                 110         


Ile Leu Ala Val Ser Asp Trp Leu Cys Arg Arg Val Ala Ser Cys Arg 
        115                 120                 125             


Ile Val His Thr Thr Pro Pro Leu Thr Met Arg Thr Leu Leu Thr Ala 
    130                 135                 140                 


Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Met Leu Leu Gln Phe Gln 
145                 150                 155                 160 


Phe Tyr Ser His Gly Leu Asp His Val Val Leu Val Lys Leu Ala Ser 
                165                 170                 175     


Thr Ala Val Val Ala Trp Leu Leu Gly Leu Ser Glu Thr Gln Thr Met 
            180                 185                 190         


Ala Ala Ile Ser Gln Val Trp Met Asp Gly His Pro Leu Arg Val Tyr 
        195                 200                 205             


Arg Ser Gly Ser Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala Gly Leu 
    210                 215                 220                 


Ala Cys Ser Lys Ala Thr His Leu Ala Trp Leu Thr Arg His Gly Gln 
225                 230                 235                 240 


Pro Gly Ser Pro Thr Pro Leu Thr Met Pro Arg Trp Gly Phe Tyr Ala 
                245                 250                 255     


Ala Ser Leu Gly Asn Lys Thr Phe Asp Pro Pro Gln Pro Tyr Gly Asp 
            260                 265                 270         


Trp Val Met Thr Asn Ile Leu Phe Lys Val Met Pro Val Glu Gly His 
        275                 280                 285             


Ala Leu Ser Ser Val Glu Ala Ala Leu Arg His Arg Ala Arg Met Gln 
    290                 295                 300                 


Ala Arg Gly Met Lys His Pro Glu Lys Asp Ile Asp Cys Ile Glu Ile 
305                 310                 315                 320 


Arg Thr Asn Ala Ala Ala Asp Gly Ile Ile Asn Lys Glu Arg Pro Leu 
                325                 330                 335     


Lys Asn Gly Ala Asp Arg Asp His Cys Leu Gln Tyr Ile Val Ser Leu 
            340                 345                 350         


Ala Phe Leu His Gly Thr Met Pro His Val Arg Asp Tyr Gln Asp Asp 
        355                 360                 365             


Ser Val Trp Ser Ser Ser Arg Ala Ile Thr Ala Leu Arg Glu Lys Ile 
    370                 375                 380                 


His Ile Gln Pro Asp Glu Gln Leu Thr Arg Glu Tyr Leu Asp Leu Asp 
385                 390                 395                 400 


Val Lys Arg Arg Ala Ser Asp Met Thr Val Arg Leu Ile Asp Gly Thr 
                405                 410                 415     


Val Leu Asp Glu Ile Leu Val Glu His Pro Glu Gly His Ser Lys His 
            420                 425                 430         


Pro Gln Thr Ala Thr Thr Val Leu Glu Lys Val Arg Thr Asn Leu Lys 
        435                 440                 445             


Leu Met Phe Ser Thr Glu Glu Ile Ser Arg Met Ala Ala Ala Val Glu 
    450                 455                 460                 


Glu Glu Ser Met Gly Ile Asn Gly Phe Val Glu Leu Phe Val Glu Pro 
465                 470                 475                 480 


Arg Ser Glu Val Lys Leu 
                485     


<210>  76
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 71

<400>  76

Met Gln Ala Tyr Asp Gln Val Ile Asp Arg Ile Lys Asp Tyr Val Phe 
1               5                   10                  15      


Ser Tyr Asp Val Asp Ser Pro Gln Ala Ala Thr Glu Ala Arg Val Ala 
            20                  25                  30          


Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Val Pro Leu Ser Ala 
        35                  40                  45              


Asp Cys Arg Arg Ala Phe Arg Pro Ile Val Pro Asp Thr Val Thr Pro 
    50                  55                  60                  


Tyr Gly Phe His Met Pro Gly Asp Ser Ala Val Leu Asp Pro Leu Lys 
65                  70                  75                  80  


Gly Ser Phe Asp Met Ala Thr Ala Val Arg Tyr Leu Asp His Asn Asp 
                85                  90                  95      


Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu Gly Ala 
            100                 105                 110         


Ile Leu Ala Val Ser Asp Trp Phe Cys Arg Thr Val Ala Ser Cys Arg 
        115                 120                 125             


Ile Val His Thr Gly Pro Pro Leu Thr Met Arg Thr Leu Leu Thr Ala 
    130                 135                 140                 


Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Met Leu Leu Gln Ile Ala 
145                 150                 155                 160 


Thr Asn Lys His Gly Leu Asp His Val Val Trp Val Lys Leu Ala Ser 
                165                 170                 175     


Thr Ala Val Val Ala Trp Leu Leu Gly Leu Ser Glu Thr Gln Thr Met 
            180                 185                 190         


Ala Ala Ile Ser Gln Val Trp Met Asp Gly His Pro Leu Arg Val Ser 
        195                 200                 205             


Arg Ser Gly Ser Asn Thr Ile Pro Arg Lys Pro Trp Ala Ala Gly Asp 
    210                 215                 220                 


Ala Cys Met Lys Ala Thr Val Leu Ala Leu Leu Thr Arg Ala Gly Gln 
225                 230                 235                 240 


Pro Gly Ser Pro Ser Pro Leu Thr Met Pro Arg Asp Gly Phe Tyr Ala 
                245                 250                 255     


Val Ser Phe Gly Asn Lys Thr Phe Asp Leu Pro Gln Pro Tyr Gly Ser 
            260                 265                 270         


Trp Val Met Glu Asn Ile Ile Phe Lys Trp Met Pro Val Glu Gly His 
        275                 280                 285             


Ala Leu Ser Ser Val Glu Ala Ala Leu Arg His Arg Ala Arg Val Lys 
    290                 295                 300                 


Ala Arg Gly Met Lys His Pro Glu Lys Asp Ile Asp Cys Ile Arg Ile 
305                 310                 315                 320 


Tyr Thr Asn Ala Ala Ala Asp Met Ile Ile Asn Lys Arg Gly Pro Lys 
                325                 330                 335     


His Asn Gln Glu Asp Arg Asp His Cys Leu Gln Tyr Ile Val Ser Leu 
            340                 345                 350         


Ala Phe Leu Asp Gly Thr Met Pro Ala Val Arg Asp Tyr Gln Asp Asp 
        355                 360                 365             


Ser Val Trp Ser Leu Ser Arg Ala Ile Thr Ala Leu Arg Glu Lys Ile 
    370                 375                 380                 


Gln Ile Gln Pro Asp Glu Gln Leu Thr Arg Asp Tyr Leu Asp Leu Asp 
385                 390                 395                 400 


Val Lys Ser Leu Ala Ser Glu Met Thr Val Arg Leu Ile Asp Gly Thr 
                405                 410                 415     


Val Leu Asp Glu Ile Leu Val Val Phe Pro Val Gly His Ser Lys His 
            420                 425                 430         


Pro Gln Thr Phe Thr Thr Val Leu Glu Lys Val Arg Asp Asn Leu Ser 
        435                 440                 445             


Ala Met Phe Ser Thr Glu Ala Ile Glu Arg Met Glu Ala Ala Phe Glu 
    450                 455                 460                 


Glu Glu Ser Leu Gly Ile Ser Gly Phe Val Asp Leu Phe Val Leu Ala 
465                 470                 475                 480 


Arg Ser Glu Val Lys Leu 
                485     


<210>  77
<211>  653
<212>  PRT
<213>  Talaromyces stipitatus

<400>  77

Ala Thr Gly Ala Thr Thr Cys Thr Ala Thr Thr Thr Thr Cys Thr Ala 
1               5                   10                  15      


Thr Thr Thr Thr Thr Gly Thr Ala Gly Cys Thr Cys Thr Thr Cys Thr 
            20                  25                  30          


Thr Gly Cys Cys Gly Cys Thr Ala Cys Thr Ala Gly Ala Gly Cys Gly 
        35                  40                  45              


Cys Ala Ala Thr Cys Thr Cys Ala Gly Ala Cys Ala Cys Cys Thr Cys 
    50                  55                  60                  


Cys Thr Gly Gly Gly Thr Thr Thr Ala Ala Gly Cys Cys Cys Thr Cys 
65                  70                  75                  80  


Thr Ala Cys Thr Gly Ala Gly Cys Thr Ala Cys Ala Cys Cys Thr Cys 
                85                  90                  95      


Gly Gly Cys Gly Thr Gly Ala Cys Ala Thr Thr Thr Cys Ala Ala Gly 
            100                 105                 110         


Ala Thr Gly Gly Ala Gly Thr Thr Thr Cys Ala Gly Thr Cys Cys Ala 
        115                 120                 125             


Ala Gly Cys Thr Gly Gly Cys Cys Ala Thr Gly Ala Ala Thr Thr Ala 
    130                 135                 140                 


Thr Thr Gly Gly Cys Ala Ala Ala Thr Gly Gly Thr Ala Ala Ala Thr 
145                 150                 155                 160 


Cys Thr Ala Cys Thr Cys Ala Gly Thr Cys Cys Ala Gly Cys Gly Cys 
                165                 170                 175     


Thr Thr Thr Cys Ala Cys Thr Cys Thr Ala Ala Gly Cys Gly Ala Thr 
            180                 185                 190         


Thr Cys Thr Ala Ala Cys Ala Ala Ala Ala Thr Thr Cys Ala Cys Ala 
        195                 200                 205             


Ala Gly Ala Ala Gly Cys Cys Ala Ala Ala Thr Cys Cys Gly Cys Thr 
    210                 215                 220                 


Cys Cys Thr Cys Ala Ala Cys Thr Cys Gly Ala Thr Thr Thr Gly Cys 
225                 230                 235                 240 


Ala Cys Thr Cys Gly Cys Thr Cys Cys Thr Ala Gly Cys Thr Ala Thr 
                245                 250                 255     


Thr Cys Ala Cys Cys Ala Thr Ala Cys Cys Cys Ala Ala Ala Cys Ala 
            260                 265                 270         


Cys Cys Cys Thr Thr Cys Thr Ala Cys Cys Ala Thr Thr Cys Gly Ala 
        275                 280                 285             


Cys Thr Thr Gly Gly Ala Ala Ala Thr Thr Cys Ala Thr Gly Gly Thr 
    290                 295                 300                 


Thr Thr Thr Cys Ala Thr Gly Ala Thr Cys Gly Ala Cys Ala Thr Ala 
305                 310                 315                 320 


Gly Ala Cys Gly Thr Thr Gly Ala Ala Cys Gly Thr Ala Ala Cys Gly 
                325                 330                 335     


Gly Cys Ala Cys Cys Ala Ala Gly Thr Ala Thr Cys Cys Thr Cys Thr 
            340                 345                 350         


Thr Cys Thr Ala Cys Ala Thr Thr Gly Gly Thr Ala Cys Cys Ala Ala 
        355                 360                 365             


Cys Cys Gly Gly Ala Cys Cys Thr Cys Ala Thr Cys Cys Thr Cys Ala 
    370                 375                 380                 


Gly Cys Gly Gly Thr Cys Gly Ala Ala Cys Cys Gly Gly Cys Ala Gly 
385                 390                 395                 400 


Ala Cys Thr Ala Thr Cys Gly Ala Thr Thr Gly Ala Ala Ala Gly Thr 
                405                 410                 415     


Gly Ala Thr Ala Gly Cys Ala Ala Cys Ala Thr Gly Cys Cys Ala Ala 
            420                 425                 430         


Ala Gly Gly Cys Ala Ala Thr Gly Thr Ala Thr Gly Cys Thr Gly Gly 
        435                 440                 445             


Thr Cys Cys Ala Gly Cys Gly Cys Cys Thr Cys Cys Ala Cys Cys Gly 
    450                 455                 460                 


Gly Gly Ala Cys Cys Cys Gly Cys Thr Cys Ala Thr Cys Gly Thr Thr 
465                 470                 475                 480 


Ala Thr Gly Thr Thr Gly Ala Ala Gly Thr Gly Ala Thr Ala Thr Thr 
                485                 490                 495     


Cys Ala Ala Ala Cys Ala Ala Cys Cys Ala Gly Ala Ala Ala Gly Ala 
            500                 505                 510         


Thr Ala Thr Gly Ala Gly Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly 
        515                 520                 525             


Ala Thr Thr Thr Cys Gly Ala Gly Ala Ala Gly Thr Thr Thr Thr Thr 
    530                 535                 540                 


Ala Gly Ala Gly Ala Ala Cys Ala Cys Gly Ala Thr Thr Gly Cys Gly 
545                 550                 555                 560 


Gly Cys Gly Ala Gly Gly Thr Thr Gly Gly Gly Gly Thr Thr Thr Gly 
                565                 570                 575     


Ala Thr Ala Thr Cys Gly Ala Gly Cys Ala Ala Thr Thr Thr Gly Thr 
            580                 585                 590         


Gly Ala Ala Ala Gly Ala Ala Gly Cys Cys Gly Gly Gly Cys Thr Gly 
        595                 600                 605             


Ala Gly Thr Gly Ala Ala Cys Cys Ala Gly Thr Thr Gly Cys Thr Gly 
    610                 615                 620                 


Gly Gly Ala Ala Cys Thr Gly Gly Thr Thr Thr Thr Thr Gly Ala Cys 
625                 630                 635                 640 


Ala Gly Cys Ala Ala Cys Gly Ala Gly Cys Thr Gly Ala 
                645                 650             


<210>  78
<211>  198
<212>  PRT
<213>  Talaromyces stipitatus

<400>  78

Met Ile Leu Phe Ser Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Leu His Leu 
            20                  25                  30          


Gly Val Thr Phe Gln Asp Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Ser Ala Pro Gln Leu Asp Leu His Ser Leu 
    50                  55                  60                  


Leu Ala Ile His His Thr Gln Thr Pro Phe Tyr His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Ser Gly Arg 
            100                 105                 110         


Thr Gly Arg Leu Ser Ile Glu Ser Asp Ser Asn Met Pro Lys Ala Met 
        115                 120                 125             


Tyr Ala Gly Pro Ala Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Val Ile Phe Lys Gln Pro Glu Arg Tyr Glu Leu Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Lys Phe Leu Glu Asn Thr Ile Ala Ala Arg Leu Gly Phe Asp Ile Glu 
                165                 170                 175     


Gln Phe Val Lys Glu Ala Gly Leu Ser Glu Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Ser 
        195             


<210>  79
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  79

Met Ile Leu Phe Ser Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Ile His Leu 
            20                  25                  30          


Gly Val Thr Phe Asn Asp Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Ser Ala Pro Gln Leu Asp Leu His Ser Leu 
    50                  55                  60                  


Leu Ala Ile His His Thr Gln Ser Pro Phe Phe His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Ser Gly Arg 
            100                 105                 110         


Thr Gly Arg Leu Ser Ile Glu Ser Asp Thr Asn Met Pro Lys Ala Met 
        115                 120                 125             


Tyr Ala Gly Pro Ala Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Val Ile Phe Lys Gln Pro Asp Arg Tyr Glu Leu Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Arg Phe Leu Glu Asn Thr Leu Ala Ala Arg Leu Gly Phe Asp Ile Glu 
                165                 170                 175     


Asn Phe Val Lys Glu Ala Gly Leu Ser Glu Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Thr 
        195             


<210>  80
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  80

Met Ile Leu Phe Thr Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Leu His Leu 
            20                  25                  30          


Gly Val Thr Phe Gln Asp Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Ser Ala Pro Gln Leu Asp Leu His Ser Leu 
    50                  55                  60                  


Leu Ala Ile His His Thr Gln Thr Pro Phe Tyr His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Val Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Ser Gly Arg 
            100                 105                 110         


Ser Gly Arg Val Ser Val Glu Ser Asp Ser Asn Ile Pro Lys Ala Met 
        115                 120                 125             


Tyr Ala Gly Pro Ala Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Leu Ile Phe Lys Gln Pro Glu Arg Tyr Glu Leu Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Lys Tyr Leu Glu Asn Thr Ile Ala Ala Arg Ile Gly Phe Asp Ile Glu 
                165                 170                 175     


Gln Phe Val Lys Glu Ala Gly Leu Ser Glu Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Ser Ser 
        195             


<210>  81
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  81

Met Leu Leu Phe Ser Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Val His Leu 
            20                  25                  30          


Gly Val Thr Phe Gln Asp Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Thr Ala Pro Gln Leu Glu Leu His Ser Leu 
    50                  55                  60                  


Leu Ala Ile His His Thr Asn Thr Pro Phe Phe His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Ser Ala Arg 
            100                 105                 110         


Thr Gly Arg Leu Ser Leu Glu Thr Asp Ser Asn Met Pro Lys Ala Met 
        115                 120                 125             


Tyr Ala Gly Pro Gly Pro Pro Pro Gly Pro Ala His Arg Tyr Leu Glu 
    130                 135                 140                 


Val Ile Phe Lys Gln Pro Glu Arg Tyr Glu Leu Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Lys Phe Leu Glu Asn Thr Ile Ala Ala Arg Leu Gly Phe Asp Val Glu 
                165                 170                 175     


Asn Phe Val Lys Glu Ala Gly Leu Ser Asp Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Ser 
        195             


<210>  82
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  82

Met Ile Leu Phe Thr Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Val His Leu 
            20                  25                  30          


Gly Val Thr Phe Gln Asp Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Arg Ser Ala Pro Gln Leu Asp Leu His Ser Leu 
    50                  55                  60                  


Leu Gly Ile His His Thr Gln Ser Pro Phe Tyr His Thr Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Thr Gly Arg 
            100                 105                 110         


Thr Gly Arg Ile Ser Ile Glu Ser Asp Ser Asn Met Pro Lys Ala Met 
        115                 120                 125             


Tyr Gly Gly Pro Gly Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Leu Ile Phe Lys Gln Pro Glu Arg Tyr Glu Val Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Lys Phe Leu Asp Asn Thr Ile Ala Ala Arg Leu Gly Phe Asp Leu Glu 
                165                 170                 175     


Gln Phe Val Lys Glu Ala Gly Leu Ser Glu Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Ser 
        195             


<210>  83
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  83

Met Ile Leu Phe Ser Ile Phe Val Ala Leu Leu Ala Gly Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Leu His Leu 
            20                  25                  30          


Gly Val Ser Phe Gln Asp Gly Leu Ser Val Asn Gly Gly His Asp Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Ser Ala Pro Gln Leu Asp Leu His Thr Ile 
    50                  55                  60                  


Leu Ala Ile His His Thr Gln Thr Pro Phe Tyr His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Thr Gly Arg 
            100                 105                 110         


Ser Gly Arg Val Ser Ile Glu Ser Asp Ser Asn Leu Pro Lys Ala Met 
        115                 120                 125             


Tyr Gly Gly Pro Ala Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Val Ile Phe Lys Gln Pro Glu Arg Tyr Glu Val Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Lys Tyr Leu Glu Asn Ser Ile Ala Gly Arg Leu Gly Phe Glu Leu Glu 
                165                 170                 175     


Gln Phe Val Lys Glu Ala Gly Leu Ser Asp Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Ser 
        195             


<210>  84
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  84

Met Ile Leu Phe Ser Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Leu His Leu 
            20                  25                  30          


Gly Val Thr Phe Gln Asp Gly Met Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Gln Asp Ala Lys Ser Ala Pro Gln Leu Asp Leu His Ser Leu 
    50                  55                  60                  


Leu Gly Ile His His Thr Gln Thr Pro Phe Tyr His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Val Asp Ile Asp Val Glu Arg Asn Gly Thr Lys 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Ser Ala Arg 
            100                 105                 110         


Ser Gly Arg Leu Ser Ile Glu Ser Asp Ser Asn Met Pro Lys Ala Met 
        115                 120                 125             


Tyr Ala Gly Pro Gly Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Ile Ile Phe Lys Gln Pro Asp Lys Tyr Asp Val Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Arg Phe Leu Glu Asn Thr Leu Gly Ala Arg Val Gly Phe Asp Val Glu 
                165                 170                 175     


Gln Phe Val Lys Glu Ala Gly Leu Ser Asp Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Val Thr Ala Thr Ser 
        195             


<210>  85
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  85

Met Ile Leu Phe Thr Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Ile His Leu 
            20                  25                  30          


Gly Val Ser Phe Asn Glu Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Ser Ala Pro Gln Leu Glu Leu His Ser Val 
    50                  55                  60                  


Leu Ala Ile His His Ser Gln Thr Pro Phe Tyr His Thr Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Ala Ser Lys 
                85                  90                  95      


Tyr Pro Leu Val His Trp Tyr Gln Pro Asp Leu Ile Val Ser Gly Arg 
            100                 105                 110         


Thr Gly Arg Leu Ser Val Asp Thr Asp Thr Gln Val Pro Lys Ala Met 
        115                 120                 125             


Tyr Gly Gly Pro Ala Pro Pro Pro Gly Pro Ala His Arg Tyr Ile Glu 
    130                 135                 140                 


Met Ile Phe Lys Gln Pro Glu Arg Tyr Asp Met Pro Ala Asp Phe Asp 
145                 150                 155                 160 


Lys Trp Leu Glu Asn Thr Ile Ala Ala Arg Leu Ala Phe Asp Ile Glu 
                165                 170                 175     


Asn Phe Val Lys Glu Ala Gly Leu Ser Asp Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Thr 
        195             


<210>  86
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  86

Met Leu Leu Phe Thr Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Thr Thr Glu Val His Leu 
            20                  25                  30          


Gly Val Ser Phe Asn Asp Gly Val Ser Val Gln Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Lys Ser Ala Pro Gln Leu Glu Leu His Ser Leu 
    50                  55                  60                  


Leu Ala Ile His His Thr Gln Thr Pro Phe Tyr His Ser Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Ala Ser Lys 
                85                  90                  95      


Tyr Pro Leu Val His Trp Tyr Gln Pro Asp Leu Ile Leu Thr Ala Arg 
            100                 105                 110         


Thr Gly Arg Val Thr Leu Glu Thr Asp Thr Asn Leu Pro Lys Ala Met 
        115                 120                 125             


Tyr Gly Gly Pro Gly Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Leu Ile Phe Lys Gln Pro Asp Arg Tyr Glu Val Pro Gly Asp Phe Asp 
145                 150                 155                 160 


Arg Phe Leu Glu Asn Thr Leu Gly Ala Arg Ile Gly Phe Asp Ile Glu 
                165                 170                 175     


Gln Phe Val Lys Glu Ala Gly Leu Ser Asp Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Thr Ser 
        195             


<210>  87
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  87

Met Leu Leu Phe Thr Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Gln Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Val His Leu 
            20                  25                  30          


Gly Val Ser Phe Gln Asp Ala Leu Thr Val Asn Ala Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Arg Thr Ala Pro Gln Leu Glu Leu His Ser Val 
    50                  55                  60                  


Leu Ala Ile His His Thr Gln Thr Pro Phe Phe His Ser Thr Trp Arg 
65                  70                  75                  80  


Phe Met Val Phe Met Val Asp Ile Asp Val Glu Arg Asn Ala Ser Arg 
                85                  90                  95      


Tyr Pro Leu Leu His Trp Tyr Gln Pro Asp Leu Ile Leu Thr Gly Arg 
            100                 105                 110         


Ser Gly Arg Ile Ser Leu Glu Ser Asp Ser Asn Val Pro Arg Ala Met 
        115                 120                 125             


Tyr Gly Gly Pro Gly Pro Pro Pro Gly Pro Ala His Arg Tyr Val Glu 
    130                 135                 140                 


Leu Ile Phe Lys Gln Pro Glu Lys Tyr Asp Leu Pro Ala Asp Phe Glu 
145                 150                 155                 160 


Lys Phe Leu Glu Gln Ser Leu Ala Gly Arg Val Gly Phe Asp Val Asp 
                165                 170                 175     


Gln Phe Val Arg Asp Ala Gly Leu Ser Asp Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Leu Thr Ala Ser Ser 
        195             


<210>  88
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 78

<400>  88

Met Leu Leu Phe Thr Ile Phe Val Ala Leu Leu Ala Ala Thr Arg Ala 
1               5                   10                  15      


Gln Ser Asn Thr Pro Pro Gly Phe Lys Pro Ser Thr Glu Leu His Leu 
            20                  25                  30          


Gly Val Ser Phe Gln Glu Ala Leu Ser Val Asn Gly Gly His Glu Leu 
        35                  40                  45              


Leu Ala Asn Glu Ala Arg Thr Ala Pro Gln Leu Asp Leu His Ser Leu 
    50                  55                  60                  


Leu Gly Ile His His Thr Gln Thr Pro Phe Phe His Thr Thr Trp Lys 
65                  70                  75                  80  


Phe Met Val Phe Met Ile Asp Ile Asp Val Glu Arg Asn Gly Ser Arg 
                85                  90                  95      


Tyr Pro Leu Val His Trp Tyr Gln Pro Asp Leu Ile Leu Ser Gly Arg 
            100                 105                 110         


Ser Gly Arg Leu Ser Leu Glu Ser Asp Thr Asn Val Pro Lys Ala Met 
        115                 120                 125             


Tyr Gly Gly Pro Ala Pro Pro Pro Gly Pro Ala His Arg Tyr Ile Glu 
    130                 135                 140                 


Leu Ile Phe Lys Gln Pro Asp Arg Tyr Asp Val Pro Gly Asp Phe Asp 
145                 150                 155                 160 


Arg Tyr Leu Glu Gln Ser Met Ala Gly Arg Leu Gly Phe Asp Val Asp 
                165                 170                 175     


Asn Phe Val Arg Glu Ala Gly Leu Ser Glu Pro Val Ala Gly Asn Trp 
            180                 185                 190         


Phe Val Thr Ala Thr Ser 
        195             


<210>  89
<211>  709
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  89
atgcgtccag acttgtggct tcttctggcc ttggtgtgcc tccccttgat cgccgcccag       60

acgccaccag gatactggcc aaagaccccg aggggcctgg atgtcatatt tcgtgaccag      120

cagctcattc aaccgggcca attagtcctt cccgatggta atgtgatata ttcttccgac      180

cagtcagagc tttccccact aatatctgat tcgtgtagat gccatcgacc ccccggtatt      240

cggtcggcaa ggtctcagtg tgttccagtc ctacctcgcc gtgatgatcg acgtcgaagt      300

caaccacgaa ggcaccgcaa cgcccctggt gcactggcta cagcccgacc tgaaggtccg      360

cgatcccttc accggccggc tggcgaggtt gagtgatgag gacgtcccct atgtcggccc      420

gcgcccggtc cccggccctc gccataccta cgtgctcctt ttatttgagc agcccacgac      480

atatcgcttc cccgaatgct tctcgagcac ccggccgatc agcgtcgaca cccgctcggg      540

cttcaacctg gcccagttca tgcacgtcgc ggggttgcag gaacctattg cggcgagtta      600

tttcacggct cggaacgaag agacgccctc ggcgcctccg ccgagagtga cgacaacctc      660

gctgagtacc gcgccttgtg cgactccgac tcgatttgtc tggtgttga                  709


<210>  90
<211>  215
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  90

Met Arg Pro Asp Leu Trp Leu Leu Leu Ala Leu Val Cys Leu Pro Leu 
1               5                   10                  15      


Ile Ala Ala Gln Thr Pro Pro Gly Tyr Trp Pro Lys Thr Pro Arg Gly 
            20                  25                  30          


Leu Asp Val Ile Phe Arg Asp Gln Gln Leu Ile Gln Pro Gly Gln Leu 
        35                  40                  45              


Val Leu Pro Asp Asp Ala Ile Asp Pro Pro Val Phe Gly Arg Gln Gly 
    50                  55                  60                  


Leu Ser Val Phe Gln Ser Tyr Leu Ala Val Met Ile Asp Val Glu Val 
65                  70                  75                  80  


Asn His Glu Gly Thr Ala Thr Pro Leu Val His Trp Leu Gln Pro Asp 
                85                  90                  95      


Leu Lys Val Arg Asp Pro Phe Thr Gly Arg Leu Ala Arg Leu Ser Asp 
            100                 105                 110         


Glu Asp Val Pro Tyr Val Gly Pro Arg Pro Val Pro Gly Pro Arg His 
        115                 120                 125             


Thr Tyr Val Leu Leu Leu Phe Glu Gln Pro Thr Thr Tyr Arg Phe Pro 
    130                 135                 140                 


Glu Cys Phe Ser Ser Thr Arg Pro Ile Ser Val Asp Thr Arg Ser Gly 
145                 150                 155                 160 


Phe Asn Leu Ala Gln Phe Met His Val Ala Gly Leu Gln Glu Pro Ile 
                165                 170                 175     


Ala Ala Ser Tyr Phe Thr Ala Arg Asn Glu Glu Thr Pro Ser Ala Pro 
            180                 185                 190         


Pro Pro Arg Val Thr Thr Thr Ser Leu Ser Thr Ala Pro Cys Ala Thr 
        195                 200                 205             


Pro Thr Arg Phe Val Trp Cys 
    210                 215 


<210>  91
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 90

<400>  91

Met Arg Pro Asp Leu Trp Leu Leu Leu Ala Leu Val Cys Leu Pro Leu 
1               5                   10                  15      


Ile Cys Ala Gln Thr Pro Pro Asp Tyr Trp Pro Lys Thr Pro Arg Gly 
            20                  25                  30          


Leu Asp Val Ile Phe Arg Asp Gln Gln Leu Ile Gln Pro Gly Gln Leu 
        35                  40                  45              


Val Leu Pro Asp Asp Ala Ile Asp Pro Pro Val Phe Gly Arg Gln Gly 
    50                  55                  60                  


Ala Ser Val Arg Gln Ser Tyr Leu Ala Val Met Ile Asp Val Glu Val 
65                  70                  75                  80  


Asn His Glu Gly Thr Ala Thr Pro Leu Val His Trp Leu Gln Pro Asp 
                85                  90                  95      


Leu Lys Val Arg Asp Pro Phe Pro Gly Arg Leu Ala Arg Leu Ser Asp 
            100                 105                 110         


Glu Asp Val Pro Tyr Val Gly Pro Arg Pro Val Lys Gly Pro Arg His 
        115                 120                 125             


Thr Tyr Val Leu Leu Leu Phe Glu Gln Pro Thr Thr Tyr Ala Phe Pro 
    130                 135                 140                 


Gly Cys Phe Ser Ser Thr Arg Pro Thr Ser Val Asp Gln Arg Ser Gly 
145                 150                 155                 160 


Phe Asn Leu Ala Gln Phe Met His Glu Ala Gly Leu Gln Glu Pro Ile 
                165                 170                 175     


Ala Ala Ser Tyr Phe Thr Ala Arg Asn Glu Glu Thr Pro Ser Ala Pro 
            180                 185                 190         


Pro Pro Arg Val Thr Thr Thr Ser Leu Ser Thr Ala Pro Cys Ala Thr 
        195                 200                 205             


Pro Thr Arg Phe Val Trp Cys 
    210                 215 


<210>  92
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 90

<400>  92

Met Arg Pro Asp Leu Trp Leu Leu Leu Ala Leu Val Cys Leu Pro Leu 
1               5                   10                  15      


Ile Ala Ala Gln Thr Pro Pro Gly Tyr Trp Pro Lys Thr Pro Gly Gly 
            20                  25                  30          


Leu Asp Val Ser Phe Arg Asp Gln Leu Leu Ile Asp Pro Gly Gln Leu 
        35                  40                  45              


Val Leu Pro Asp Asp Ala Ile Asp Pro Pro Arg Phe Gly Arg Gln Gly 
    50                  55                  60                  


Leu Ser Val Gly Gln Ser Tyr Leu Ala Val Met Ile Asp Val Glu Val 
65                  70                  75                  80  


Asn His Glu Gly Thr Ala Thr Pro Leu Val His Trp Leu Gln Pro Asp 
                85                  90                  95      


Leu Lys Val Arg Asp Pro Phe Thr Gly Thr Leu Ala Arg Leu Ser Asp 
            100                 105                 110         


Glu Asp Val Pro Tyr Val Gly Pro Arg Pro Val Pro Gly Pro Arg His 
        115                 120                 125             


Thr Tyr Val Leu Leu Leu Phe Glu Gln Pro Thr Thr Tyr Ser Phe Pro 
    130                 135                 140                 


Glu Cys Phe Ser Ser Val Arg Pro Lys Ser Val Asp Thr Arg Leu Gly 
145                 150                 155                 160 


Phe Asn Leu Ala Gln Phe Met His Val Ala Gly Leu Gln Glu Pro Ile 
                165                 170                 175     


Ala Ala Ser Tyr Phe Thr Ala Arg Asn Glu Glu Thr Pro Ser Ala Pro 
            180                 185                 190         


Pro Pro Arg Val Thr Thr Thr Ser Leu Ser Thr Ala Pro Cys Ala Thr 
        195                 200                 205             


Pro Thr Arg Phe Val Trp Cys 
    210                 215 


<210>  93
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 90

<400>  93

Met Arg Pro Asp Leu Trp Leu Leu Leu Ala Leu Val Cys Leu Pro Leu 
1               5                   10                  15      


Ile Arg Ala Gln Thr Pro Pro Gly Tyr Trp Pro Lys Thr Pro Arg Gly 
            20                  25                  30          


Leu Ser Val Ile Phe Arg Asp Gln Ser Leu Ile Gln Pro Gly Gln Leu 
        35                  40                  45              


Val Leu Pro Asp Asp Ala Ile Gly Lys Pro Val Phe Thr Arg Gln Gly 
    50                  55                  60                  


Ala Ser Val Phe Gln Ser Tyr Leu Ala Val Met Ile Asp Val Glu Val 
65                  70                  75                  80  


Asn His Glu Gly Thr Ala Thr Pro Leu Val His Trp Leu Gln Pro Asp 
                85                  90                  95      


Leu Lys Val Arg Asp Pro Phe Ser Gly Arg Leu Ala Thr Leu Ser Thr 
            100                 105                 110         


Glu Asp Val Pro Tyr Val Gly Pro Arg Pro Val Pro Gly Pro Arg His 
        115                 120                 125             


Thr Tyr Val Leu Leu Leu Phe Glu Gln Pro Arg Thr Tyr Arg Phe Pro 
    130                 135                 140                 


Glu Ala Arg Ser Ser Thr Arg Pro Glu Ser Val Asp Glu Arg Ser Gly 
145                 150                 155                 160 


Phe Asn Leu Ala Gln Phe Met His Arg Ala Gly Leu Gln Glu Pro Ile 
                165                 170                 175     


Ala Ala Ser Tyr Phe Thr Ala Arg Asn Glu Glu Thr Pro Ser Ala Pro 
            180                 185                 190         


Pro Pro Arg Val Thr Thr Thr Ser Leu Ser Thr Ala Pro Cys Ala Thr 
        195                 200                 205             


Pro Thr Arg Phe Val Trp Cys 
    210                 215 


<210>  94
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 90

<400>  94

Met Arg Pro Asp Leu Trp Leu Leu Leu Ala Leu Val Cys Leu Pro Leu 
1               5                   10                  15      


Ile Cys Ala Gln Thr Pro Pro Met Tyr Val Pro Lys Thr Lys Arg Gly 
            20                  25                  30          


Leu Asp Val Ile Phe Arg Asp Gln Gln Leu Ile Gln Pro Gly His Leu 
        35                  40                  45              


Val Leu Pro Asp Asp Ala His Phe Pro Pro Val Phe Ser Arg Gly Gly 
    50                  55                  60                  


Leu Ser Val Phe Gln Ser Tyr Leu Ala Val Met Ile Asp Val Glu Val 
65                  70                  75                  80  


Asn His Glu Gly Thr Phe Thr Pro Leu Val His Trp Leu Gln Pro Asp 
                85                  90                  95      


Leu Lys Val Arg Asp Asp Phe Thr Gly Arg Leu Ile Arg Leu Ser Asp 
            100                 105                 110         


Glu Asp Val Arg Tyr Val Gly Pro Arg Pro Val Pro Gly Pro Arg His 
        115                 120                 125             


Thr Tyr Val Leu Leu Leu Phe Glu Gln Pro Asp Thr Tyr Arg Val Pro 
    130                 135                 140                 


Glu His Phe Ser Ser Ile Arg Pro Asn Ser Gly Asp Thr Arg Gly Gly 
145                 150                 155                 160 


Phe Asn Leu Ala Gln Phe Met Ala Val Ala Gly Leu Gln Glu Pro Ile 
                165                 170                 175     


Ala Ala Ser Tyr Phe Thr Ala Arg Asn Glu Thr Thr Pro Ser Ala Pro 
            180                 185                 190         


Pro Pro Arg Val Thr Thr Thr Ser Leu Ser Thr Ala Pro Cys Ala Thr 
        195                 200                 205             


Pro Thr Arg Phe Val Trp Cys 
    210                 215 


<210>  95
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 90

<400>  95

Met Arg Pro Asp Leu Trp Leu Leu Leu Ala Leu Val Cys Leu Pro Leu 
1               5                   10                  15      


Ile Ala Ala Gln Thr Pro Pro Gly Tyr Trp Pro Lys Thr Gln Arg Gln 
            20                  25                  30          


Leu Asp Val Ile Phe Arg Asp Arg Ile Val Ile Asn Pro Gly Gln Leu 
        35                  40                  45              


Val Leu Pro Asp Asp Ala Met Ile Pro Pro Val Phe Gly Arg Gln Gly 
    50                  55                  60                  


Leu Ser Val Ser Gln Ser Tyr Leu Ala Val Met Ile Asp Val Glu Val 
65                  70                  75                  80  


Asn His Glu Gly Lys Ala Thr Pro Leu Val His Trp Leu Gln Pro Asp 
                85                  90                  95      


Leu Lys Val Arg Asp Pro Phe Thr Gly Arg Leu Ala Phe Pro Ser Val 
            100                 105                 110         


Glu Asp Val Pro Tyr Val Gly Pro Arg Pro Val Arg Gly Pro Arg His 
        115                 120                 125             


Thr Tyr Val Leu Leu Leu Phe Glu Gln Pro Thr Thr Tyr Arg Ser Pro 
    130                 135                 140                 


Glu Thr Phe Ser Ser Thr Asn Pro Asp Asp Gly Asp Thr Arg Ser Gly 
145                 150                 155                 160 


Phe Asn Leu Ala Gln Phe Met Glu Ala Ala Gly Leu Gln Glu Pro Ile 
                165                 170                 175     


Ala Ala Ser Tyr Phe Thr Ala Arg Asn Glu Glu Thr Pro Ser Ala Pro 
            180                 185                 190         


Pro Pro Arg Val Thr Thr Thr Ser Leu Ser Thr Ala Pro Cys Ala Thr 
        195                 200                 205             


Pro Thr Arg Phe Val Trp Cys 
    210                 215 


<210>  96
<211>  814
<212>  DNA
<213>  Talaromyces stipitatus

<400>  96
atgtccagag ctcaccccaa gcagcccgtc actggaagaa atattcccat attggctatc       60

acgatgcccg cactcaagtt gctttgctta catggcgctg gcatgaattc tgaggtattg      120

ataaaactaa gtgacttagt cttatccaaa ttctaatacg gaactataga ttatgaaatc      180

tcatctgtca tccttggcca aaaccctgga ataccgcaac atcgcccaat tcgcatacgc      240

agagggatcc gtcgagacag agcccggccc tggaattacc ccaggcttat acgagggccc      300

atattactcc tttcacatct ggcctccaaa agcgggaaac ctacaagacg aagaatccat      360

ccaaaatgca tatgaagagc tcctcgagat aatcgacgac gagggtccat ttgacggact      420

attgggtttt tctcacggcg gttcattcct tgctgaatta ttagccagat acgctcgtga      480

taatcctgca acagatgttg aacggctagc tcgctgtgcg gtctttatta attcgttccc      540

accttttcgt aacgatccgg accagaaccc gattattgat tatgagctgt tgaagcactt      600

cccaaaaatc ccgactttgc atgtcgtcgg tacgtcggat tttgtgcatg agtattcgac      660

tatcttgtat gaaaagttgc accaaaaggc gccaacatcg acgggattgg tcactcattc      720

taaaggtcat gagattccga gagatccaaa ggttctggat aaggttgtcg ctggctttga      780

gaagttgaat tttgctgttt ctttcagcca ttga                                  814


<210>  97
<211>  231
<212>  PRT
<213>  Talaromyces stipitatus

<400>  97

Met Pro Ala Leu Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Lys Ser His Leu Ser Ser Leu Ala Lys Thr Leu Glu Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Ile Thr Pro Gly Leu Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Lys Ala Gly Asn Leu Gln Asp Glu Glu Ser 
65                  70                  75                  80  


Ile Gln Asn Ala Tyr Glu Glu Leu Leu Glu Ile Ile Asp Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Arg Asp Asn Pro Ala Thr Asp Val Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Phe Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Asp Gln Asn Pro Ile Ile Asp Tyr Glu Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Glu Lys Leu His Gln Lys Ala Pro 
            180                 185                 190         


Thr Ser Thr Gly Leu Val Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Val Leu Asp Lys Val Val Ala Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Ala Val Ser Phe Ser His 
225                 230     


<210>  98
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  98

Met Pro Ala Met Lys Leu Leu Cys Leu His Gly Gly Gly Met Asn Ser 
1               5                   10                  15      


Glu Leu Met Lys Ser His Leu Ser Ser Leu Ala Lys Ser Leu Glu Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Leu Glu Thr Glu 
        35                  40                  45              


Pro Ala Pro Gly Ile Thr Pro Gly Leu Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Tyr Pro Pro Lys Ala Gly Asn Leu Gln Asp Glu Glu Ser 
65                  70                  75                  80  


Leu Gln Asn Ala Tyr Asp Glu Leu Met Glu Ile Ile Asp Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Arg Asp Asn Pro Ala Thr Asp Val Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Phe Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Asp Gln Asn Pro Ile Leu Asp Tyr Glu Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Glu Lys Leu His Gln Lys Ala Pro 
            180                 185                 190         


Thr Ser Thr Gly Leu Val Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Val Leu Asp Lys Val Val Ala Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Ala Val Thr Phe Ser His 
225                 230     


<210>  99
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  99

Met Pro Ala Leu Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Lys Ser His Val Ser Ser Leu Ala Lys Thr Leu Glu Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Ala Pro Gly Ile Thr Pro Gly Leu Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Lys Ala Gly Asn Leu Gln Asp Glu Glu Ser 
65                  70                  75                  80  


Ile Gln Asn Ala Tyr Glu Glu Leu Leu Glu Ile Ile Glu Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Arg Asp Asn Pro Ala Ser Asp Val Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Phe Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Asp Gln Asn Pro Leu Val Glu Trp Glu Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Glu Lys Leu His Gln Lys Ala Pro 
            180                 185                 190         


Ser Ser Thr Gly Leu Ile Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Val Leu Glu Lys Val Val Ala Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Ala Ile Ser Phe Ser His 
225                 230     


<210>  100
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  100

Met Pro Ala Met Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Arg Ser His Leu Ser Ser Leu Ala Lys Thr Leu Glu Tyr 
            20                  25                  30          


Arg Gln Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Ile Thr Pro Gly Leu Tyr Asp Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Val Trp Pro Pro Lys Gly Gly Asn Leu Gln Asp Glu Glu Ser 
65                  70                  75                  80  


Leu Gln Asn Ala Tyr Glu Glu Leu Leu Glu Leu Ile Asp Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Asp Leu Leu Ala Arg Tyr Ala Lys Asp Gln Pro Ala Thr Asp Val Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Tyr Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Asp Gln Asn Pro Leu Ile Asp Tyr Glu Met Leu Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Ser Ser Asp Phe Val 
                165                 170                 175     


His Glu Trp Ser Thr Ile Leu Tyr Glu Lys Leu His Gln Lys Ala Pro 
            180                 185                 190         


Ser Ser Thr Gly Leu Val Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Val Leu Asp Lys Val Val Ala Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Ala Val Ser Phe Ser His 
225                 230     


<210>  101
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  101

Met Pro Ala Leu Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Arg Ser His Leu Ser Ser Leu Ala Arg Thr Leu Glu Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Ile Thr Pro Ala Leu Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Lys Ala Gly Asn Leu Gln Asp Glu Glu Ser 
65                  70                  75                  80  


Ile Gln Asn Ala Tyr Glu Glu Leu Leu Glu Leu Ile Asp Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Arg Asp Asn Pro Ala Thr Glu Val Glu 
        115                 120                 125             


Arg Ile Ala Arg Cys Ala Val Phe Ile Asn Ser Phe Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Glu Gln Asn Pro Leu Leu Asp Tyr Glu Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Arg Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Glu Lys Leu His Gln Lys Ala Pro 
            180                 185                 190         


Thr Thr Thr Gly Leu Leu Ser His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Met Leu Asp Lys Val Ile Ala Gly Phe Glu Lys Val Asn 
    210                 215                 220                 


Phe Ala Val Thr Phe Ser His 
225                 230     


<210>  102
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  102

Met Pro Ala Leu Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Lys Ser His Leu Ser Ser Leu Ala Lys Thr Leu Glu Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Ile Thr Pro Gly Ile Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Lys Ala Gly Asn Leu Gln Asp Glu Glu Ser 
65                  70                  75                  80  


Leu Gln Gln Ala Tyr Glu Glu Leu Ile Glu Leu Ile Glu Asp Asp Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Lys Asp Asn Pro Ala Thr Asp Val Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Phe Pro Pro Phe Lys 
    130                 135                 140                 


Asn Asp Pro Asp Asn Gln Pro Leu Ile Asp Tyr Asp Leu Ile Arg His 
145                 150                 155                 160 


Phe Pro Arg Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Leu Leu Tyr Glu Lys Leu His Gln Arg Ala Pro 
            180                 185                 190         


Thr Ser Thr Gly Val Val Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Met Val Glu Arg Val Val Ala Gly Phe Glu Lys Leu Gln 
    210                 215                 220                 


Phe Ala Val Ser Phe Ser His 
225                 230     


<210>  103
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  103

Met Pro Ala Leu Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Lys Ser His Leu Ser Ser Leu Ala Lys Ser Leu Glu Tyr 
            20                  25                  30          


Arg Gln Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Ile Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Ile Thr Pro Ala Leu Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Arg Ala Gly Asn Leu Gln Asp Asp Glu Ser 
65                  70                  75                  80  


Val Gln Asn Ala Tyr Asp Asp Leu Met Glu Leu Ile Asp Asp Glu Gly 
                85                  90                  95      


Pro Trp Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Arg Glu Asn Pro Ala Thr Glu Val Asp 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Tyr Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Asp Gln Asn Pro Leu Ile Asp Tyr Glu Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Leu Leu Tyr Glu Lys Leu His Gln Lys Ala Pro 
            180                 185                 190         


Thr Ser Thr Gly Met Ile Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Arg Val Ile Glu Lys Val Val Ala Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Ala Met Ser Phe Ser His 
225                 230     


<210>  104
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  104

Met Pro Ala Met Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Asp Ile Met Arg Thr His Leu Ser Thr Leu Ala Lys Thr Leu Asp Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Val Thr Pro Ala Val Phe Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Lys Ala Gly Gln Leu Asn Asp Glu Glu Ser 
65                  70                  75                  80  


Ile Gln Asn Ala Tyr Asp Glu Leu Ile Glu Leu Ile Asp Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Asp Leu Leu Ala Arg Phe Ala Arg Glu Asn Pro Ala Thr Asp Val Asp 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Tyr Pro Pro Phe Arg 
    130                 135                 140                 


Asn Glu Pro Glu Asn Asn Pro Ile Val Asp Trp Glu Ile Leu Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Thr Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Asp Lys Leu His Asn Arg Ala Pro 
            180                 185                 190         


Thr Thr Ser Ala Leu Leu Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Val Leu Glu Lys Val Val Ala Gly Phe Asp Lys Leu Asn 
    210                 215                 220                 


Phe Ala Val Ser Phe Ser His 
225                 230     


<210>  105
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  105

Met Pro Ala Met Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Ile Met Lys Ser His Leu Ser Ser Leu Gly Lys Thr Leu Glu Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Glu Thr Glu 
        35                  40                  45              


Pro Gly Pro Gly Ile Thr Pro Gly Leu Phe Asp Ala Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Phe Pro Pro Lys Ala Gly Asn Leu Gln Glu Glu Asp Ser 
65                  70                  75                  80  


Leu Gln Asn Ala Tyr Asp Glu Leu Leu Glu Leu Ile Asp Glu Asp Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Glu Leu Leu Ala Arg Tyr Ala Arg Asp Asn Pro Ala Ser Asp Leu Glu 
        115                 120                 125             


Lys Met Ala Arg Cys Ala Val Phe Ile Asn Ser Phe Pro Pro Tyr Arg 
    130                 135                 140                 


Asn Glu Pro Asp Gln Asn Pro Leu Leu Asp Tyr Asp Leu Ile Lys His 
145                 150                 155                 160 


Phe Pro Lys Ile Pro Thr Leu His Val Val Gly Ser Ser Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Glu Lys Val His Asn Lys Ala Pro 
            180                 185                 190         


Thr Thr Thr Gly Met Leu Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Val Ile Asp Arg Val Val Ala Gly Phe Asp Arg Ile Asn 
    210                 215                 220                 


Phe Gly Val Ser Phe Ser His 
225                 230     


<210>  106
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  106

Met Pro Ala Met Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Leu Met Lys Ser His Leu Ser Ser Leu Ala Lys Thr Leu Asp Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Val Asp Ser Glu 
        35                  40                  45              


Pro Gly Pro Gly Leu Ser Pro Ala Leu Phe Glu Gly Pro Phe Tyr Ser 
    50                  55                  60                  


Phe His Ile Phe Pro Pro Lys Ala Ala Asn Met Gln Glu Glu Glu Ser 
65                  70                  75                  80  


Leu Gln Asn Ala Tyr Glu Asp Leu Val Glu Val Ile Glu Asp Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Asp Leu Leu Ala Arg Phe Ala Lys Glu Gln Pro Ala Thr Asp Leu Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Trp Pro Pro Trp Arg 
    130                 135                 140                 


Gln Asp Pro Asp Asn Gln Pro Leu Val Asp Tyr Asp Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Arg Ile Pro Thr Leu His Val Val Gly Thr Thr Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Ile Leu Tyr Asp Lys Leu His Asn Lys Ala Pro 
            180                 185                 190         


Ser Thr Thr Gly Val Val Thr His Ser Lys Gly His Asp Ile Pro Arg 
        195                 200                 205             


Asp Pro Lys Ile Val Asp Lys Val Val Gly Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Gly Val Ser Tyr Thr His 
225                 230     


<210>  107
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 97

<400>  107

Met Pro Ala Met Lys Leu Leu Cys Leu His Gly Ala Gly Met Asn Ser 
1               5                   10                  15      


Glu Val Met Lys Ser His Ile Ser Thr Leu Ala Lys Thr Leu Asp Tyr 
            20                  25                  30          


Arg Asn Ile Ala Gln Phe Ala Tyr Ala Glu Gly Ser Ile Asp Thr Asp 
        35                  40                  45              


Pro Ala Pro Gly Val Ser Pro Gly Val Tyr Glu Gly Pro Tyr Tyr Ser 
    50                  55                  60                  


Phe His Ile Trp Pro Pro Arg Gly Gly Asn Leu Gln Asp Glu Asp Ser 
65                  70                  75                  80  


Leu Gln Asn Ala Tyr Asp Asp Leu Met Asp Val Ile Glu Glu Glu Gly 
                85                  90                  95      


Pro Phe Asp Gly Leu Leu Gly Phe Ser His Gly Gly Ser Phe Leu Ala 
            100                 105                 110         


Asp Leu Leu Ala Arg Phe Ala Lys Asp Gln Pro Gly Thr Glu Val Glu 
        115                 120                 125             


Arg Leu Ala Arg Cys Ala Val Phe Ile Asn Ser Tyr Pro Pro Phe Arg 
    130                 135                 140                 


Asn Asp Pro Glu Gln Gln Pro Leu Ile Asp Tyr Glu Leu Leu Lys His 
145                 150                 155                 160 


Phe Pro Arg Ile Pro Thr Leu His Val Val Gly Thr Thr Asp Phe Val 
                165                 170                 175     


His Glu Tyr Ser Thr Met Leu Tyr Glu Arg Met His Gln Arg Ala Pro 
            180                 185                 190         


Thr Ser Ser Gly Val Ile Thr His Ser Lys Gly His Glu Ile Pro Arg 
        195                 200                 205             


Glu Pro Lys Met Val Glu Arg Val Val Ala Gly Phe Glu Lys Leu Asn 
    210                 215                 220                 


Phe Ala Val Ser Phe Ser His 
225                 230     


<210>  108
<211>  814
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  108
atgccggtga gatttctttg tctgcatggc tggggcacca atatccaggt tcgtgcgatg       60

accgaaagta atccaatggc tcgcgcctcg agtgactgac cataatttat ctggcagatc      120

ttacagtccc aactcggtag acaccgcagc cctacaaaag aaaaaacaaa aaaaaacccc      180

ctaaccgtga acaggccccc taatgcgaga gctgcagaaa gacaacagcg cggaatttca      240

tttcatccag ggcgatgtcg aggcagatcc cggcccaggt atcgagggct tctacgaagg      300

gccctactac agcttctacc aattcccccg gactttcccc gacagtgatg acgaggagga      360

cgatggcgga gatgcgtcca tgttcgaggc ctatgagatg atctacgaca tcatagccga      420

ggagggtcct tttgacggca tcctcggctt ctctcacggc ggcaccttgg cctcgggctt      480

cctcatccat cacagtaaga cctcccctta tacgccgccc cccttccgat gcgccgtgtt      540

tttcaattca ctgccgccgt tccgcatgga tcccggcgag gagcttgtcg tggatgatga      600

tctggcccgg cacctcacga taccgaccct cagcattgcg gggacgcggg actttgtcta      660

caagcagtct ctgatgctgc accagttgtg cgatgagaag tcgtcgcagc tgatcctgca      720

tggaaagggc cacgagatcc cgggggatgc ggcgacggtg gcgcggatgg ctaaggcatt      780

tcgggcactg tgtttgcggg ccatgtattt gtag                                  814


<210>  109
<211>  200
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  109

Met Pro Lys Asp Asn Ser Ala Glu Phe His Phe Ile Gln Gly Asp Val 
1               5                   10                  15      


Glu Ala Asp Pro Gly Pro Gly Ile Glu Gly Phe Tyr Glu Gly Pro Tyr 
            20                  25                  30          


Tyr Ser Phe Tyr Gln Phe Pro Arg Thr Phe Pro Asp Ser Asp Asp Glu 
        35                  40                  45              


Glu Asp Asp Gly Gly Asp Ala Ser Met Phe Glu Ala Tyr Glu Met Ile 
    50                  55                  60                  


Tyr Asp Ile Ile Ala Glu Glu Gly Pro Phe Asp Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Ser His Gly Gly Thr Leu Ala Ser Gly Phe Leu Ile His His Ser Lys 
                85                  90                  95      


Thr Ser Pro Tyr Thr Pro Pro Pro Phe Arg Cys Ala Val Phe Phe Asn 
            100                 105                 110         


Ser Leu Pro Pro Phe Arg Met Asp Pro Gly Glu Glu Leu Val Val Asp 
        115                 120                 125             


Asp Asp Leu Ala Arg His Leu Thr Ile Pro Thr Leu Ser Ile Ala Gly 
    130                 135                 140                 


Thr Arg Asp Phe Val Tyr Lys Gln Ser Leu Met Leu His Gln Leu Cys 
145                 150                 155                 160 


Asp Glu Lys Ser Ser Gln Leu Ile Leu His Gly Lys Gly His Glu Ile 
                165                 170                 175     


Pro Gly Asp Ala Ala Thr Val Ala Arg Met Ala Lys Ala Phe Arg Ala 
            180                 185                 190         


Leu Cys Leu Arg Ala Met Tyr Leu 
        195                 200 


<210>  110
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 109

<400>  110

Met Pro Lys Asp Asn Ser Ala Glu Phe His Phe Ile Gln Gly Asp Val 
1               5                   10                  15      


Glu Ala Asp Pro Gly Pro Gly Ile Glu Gly Phe Tyr Ala Gly Pro Tyr 
            20                  25                  30          


Tyr Ser Phe Tyr Ala Phe Pro Arg Thr Phe Pro Asp Ser Asp Asp Glu 
        35                  40                  45              


Glu Pro Asp Gly Gly Tyr Ile Ser Met Phe Glu Ala Tyr Glu Met Ile 
    50                  55                  60                  


Tyr Asp Ile Ile Ala Glu Glu Gly Pro Phe Asp Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Ser His Gly Gly Thr Leu Ala Ser Gly Phe Leu Ile His His Ser Lys 
                85                  90                  95      


Thr Ser Pro Tyr Gly Pro Pro Pro Phe Arg Cys Ala Val Phe Phe Asn 
            100                 105                 110         


Ser Leu Pro Pro Phe Arg Met Asp Pro Gly Glu Glu Leu Val Val Asp 
        115                 120                 125             


Asp Asp Leu Ala Arg His Leu Thr Ile Pro Thr Leu Ser Ile Ala Gly 
    130                 135                 140                 


Thr Arg Asp Gln Val Tyr Lys Gln Ser Leu Met Leu His Gln Leu Cys 
145                 150                 155                 160 


Asp Glu Lys Ser Ser Gln Leu Ile Glu His Gly Lys Gly His Tyr Ile 
                165                 170                 175     


Pro Gly Asp Ala Ala Thr Val Ala Arg Met Ala Lys Ala Phe Arg Ala 
            180                 185                 190         


Leu Cys Gln Arg Ala Met Tyr Leu 
        195                 200 


<210>  111
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 109

<400>  111

Met Pro Lys Asp Asn Ser Ala Glu Phe His Phe Ile Gln Gly Asp Val 
1               5                   10                  15      


Glu Ala Asp Pro Gly Pro Gly Ile Glu Gly Phe Tyr Gln Gly Pro Tyr 
            20                  25                  30          


Tyr Ser Phe Tyr Gln Phe Pro Thr Thr Phe Pro Asp Ser Asp Asn Glu 
        35                  40                  45              


Glu Asp Asp Gly Thr Asp Ala Ser Met Phe Glu Ala Tyr Glu Thr Ile 
    50                  55                  60                  


Tyr Asp Ile Ile Asp Glu Glu Gly Pro Phe Asp Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Ser His Gly Gly Thr Leu Ala Ser Gly Phe Leu Ile His His Ser Lys 
                85                  90                  95      


Thr Ser Pro Tyr Thr Pro Pro Pro Phe Arg Cys Ala Val Phe Phe Asn 
            100                 105                 110         


Ser Leu Pro Pro Phe Arg Met Asp Pro Gly Glu Glu Leu Val Val Asp 
        115                 120                 125             


Asp Asp Leu Ala Arg Leu Leu Thr Ile Pro Thr Leu Ser Ile Ala Gly 
    130                 135                 140                 


Thr Arg Asp Pro Val Tyr Lys Gln Ser Leu Met Leu His Gln Leu Cys 
145                 150                 155                 160 


Asp Glu Lys Ser Ser Gln Leu Ile Leu His Gly Lys Gly His Glu Ile 
                165                 170                 175     


Pro Gly Asp Ala Ala Thr Val Leu Arg Met Ala Lys Val Phe Arg Ala 
            180                 185                 190         


Leu Cys Leu Arg Ala Met Tyr Leu 
        195                 200 


<210>  112
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 109

<400>  112

Met Pro Lys Asp Asn Thr Ala Glu Phe His Phe Ile Gln Gly Asp Val 
1               5                   10                  15      


Pro Ala Asp Pro Gly Pro Gly Ile Gly Gly Phe Tyr Glu Gly Pro Tyr 
            20                  25                  30          


Tyr Ser Phe Tyr Gln Phe Pro Arg Asp Phe Pro Asp Ser Asp Asp Glu 
        35                  40                  45              


Glu Asp Asp Gly Gly Asp Ala Ser Met Leu Glu Ala Tyr Glu Met Ile 
    50                  55                  60                  


Tyr Asp Ile Ile Ala Glu Glu Gly Pro Phe Asp Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Ser His Gly Gly Thr Leu Ala Ser Gly Phe Leu Ile His His Ser Arg 
                85                  90                  95      


Thr Leu Pro Tyr Thr Pro Pro Pro Phe Arg Cys Ala Val Phe Phe Asn 
            100                 105                 110         


Ser Leu Pro Pro Phe Arg Met Asp Tyr Gly Glu Tyr Leu Val Val Asp 
        115                 120                 125             


Asp Asp Glu Ala Ile His Leu Thr Ile Pro Thr Leu Ser Ile Ala Gly 
    130                 135                 140                 


Thr Arg Asp Phe Val Tyr Lys Gln Ser Leu Met Leu His Gln Leu Cys 
145                 150                 155                 160 


Asp Glu Lys Ser Ser Gln Leu Ile Thr His Gly Lys Gly His Ala Ile 
                165                 170                 175     


Pro Gly Asp Ala Ala Thr Val Ala Arg Met Ala Lys Phe Phe Arg Ala 
            180                 185                 190         


Leu Cys Leu Arg Ala Met Tyr Leu 
        195                 200 


<210>  113
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 109

<400>  113

Met Pro Lys Asp Asn Glu Ala Glu Phe His Phe Ile Gln Gly Asp Val 
1               5                   10                  15      


Glu Ala Asp Pro Gly Pro Gly Ile Glu Gly Phe Tyr Glu Gly Pro Tyr 
            20                  25                  30          


Tyr Ser Phe Tyr Gln Glu Pro Arg Ser Phe Pro Asp Ser Asp Asp Glu 
        35                  40                  45              


Glu Asp Asp Gly Glu Tyr Ala Ser Met Arg Glu Ala Tyr Glu Arg Ile 
    50                  55                  60                  


Thr Asp Ile Ile Lys Glu Glu Gly Pro Phe Asp Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Ser His Gly Gly Thr Leu Ala Ser Gly Phe Leu Ile Asp His Ser Glu 
                85                  90                  95      


Gln Ser Pro Tyr Thr Pro Pro Pro Phe Arg Cys Ala Val Phe Phe Asn 
            100                 105                 110         


Ser Leu Pro Pro Phe Arg Met Asp Arg Gly Gln Glu Leu Val Val Asp 
        115                 120                 125             


Asp Asp Leu Glu Arg His Leu Thr Ile Pro Thr Leu Ser Ile Ala Gly 
    130                 135                 140                 


Lys Arg Asp Phe Val Tyr Lys Gln Ser Leu Val Leu His Gln Leu Cys 
145                 150                 155                 160 


Asp Glu Lys Asn Ser Lys Leu Ile Glu His Gly Lys Gly His Glu Ile 
                165                 170                 175     


Pro Gly Asp Ala Ala Thr Val Ala Arg Met Ala Lys Ala Phe Arg Ala 
            180                 185                 190         


Leu Cys Leu Arg Ala Met Tyr Leu 
        195                 200 


<210>  114
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 109

<400>  114

Met Pro Lys Asp Asn Ser Ala Glu Phe His Phe Ile Gln Gly Asp Val 
1               5                   10                  15      


Glu Ala Ser Pro Gly Pro Gly Ile Glu Gly Val Tyr Asp Gly Pro Tyr 
            20                  25                  30          


Tyr Ser Phe Tyr Gln Phe Pro Arg Thr Phe Pro Asp Ser Asp Asp Glu 
        35                  40                  45              


Glu Asp Lys Gly Gly Asp Ala Ser Met Asp Glu Ala Tyr Glu Met Ile 
    50                  55                  60                  


His Asp Ile Ile Glu Glu Glu Gly Pro Phe Asp Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Ser His Gly Gly Thr Leu Ala Ser Gly Phe Leu Ile Ser His Ser His 
                85                  90                  95      


Thr Ser Pro Asp Thr Pro Pro Pro Phe Arg Cys Ala Val Phe Phe Asn 
            100                 105                 110         


Ser Leu Pro Pro Phe Asp Met Asp Pro Gly Glu Glu Leu Ile Val Asp 
        115                 120                 125             


Asp Asp Gly Arg Pro His Leu Thr Ile Pro Thr Leu Ser Ile Ala Gly 
    130                 135                 140                 


Thr Arg Asp Phe Val Tyr Lys Leu Ser Leu Met Leu His Gln Leu Cys 
145                 150                 155                 160 


Asp Glu Lys Ser Ser Gln Leu Ile Asp His Gly Lys Gly His Glu Ile 
                165                 170                 175     


Pro Val Asp Ala Ala Asp Val Ala Arg Met Ala Lys Ala Phe Arg Ala 
            180                 185                 190         


Leu Cys Ser Arg Ala Met Tyr Leu 
        195                 200 


<210>  115
<211>  1534
<212>  DNA
<213>  Talaromyces stipitatus

<400>  115
atgacagctt cagagcagac agcattgctg ggttcgccta ggaagcccgc ctacacaatc       60

ttttccaata gtcagaagct ccttattatt cttactgcga ctttagcatc tgttttttct      120

cctctttccg caaatatcta ctatccggcg ttgaaaagta ttcaaaagga gctgaatgtg      180

agcgaggaga tacttaatat gacaattacc tcttatatgg taggtttcac ctcacgaatg      240

caaaatggag cataagaaga attggacgta acaattagtc cagatattcc agggtctttc      300

accaaccttt atcggatctc tatcagacac aatcggaaga cgcccagtct acatcatttg      360

cttccttata tatattgccg ccaatgtcgg attaacattt caaaccacgt ttattggact      420

cctcctactt cgatgcctcc aaagttctgg tagtagctcg acagtaaacc tcgcctatgg      480

tgtaactgcg gatgtcgtga cgtccgctga gcgaggccga tatgtaggac tggcatctgt      540

tggcccaatc attggaccta ctttgggccc agtactcgga ggtatcatta gccagtacta      600

cggatggcga ttcatcttcg ttgttttgac gggaatggca cttatcatgc tcatttttat      660

tattgtcttc ttacctgaaa catgtcgaaa tattgtcgga aatggatctc tcgaaccact      720

ttctgtatgg aataagcctc tgagttcctt tctttgtaag aagaaagaaa atgaggacct      780

tgatgaaact ctcgaggcac aacaggctat cgaagccgcc cgtaaaaagg gtggtaagcc      840

aaagccatgg aaatcactaa ctctactctt cacataccca actggatgcg tcattctttt      900

caatggattc acatttgcta catactacgc cgttacgacc agtctcacct ggtgcttttc      960

tagtacctac cacttcaacg aggtcgaaat cggactttcc tacataccca tcggcgttgg     1020

tagcatgatt gcagctttca ccaacggatt ccttctcgac tggaactatc gacgtgcggt     1080

caagaaagtt ctcggtcggc ctcttgctcg cggcgagcat ttcgatcatg atacaggtgt     1140

cgctctcggc ttccacatcg agcggacccg cttacagatc gtcataccgg ctgtcgtgct     1200

tgccatgctg gccatggttg cttacggctg gtccgtgtat cttgtgctta cacctgctgt     1260

tcctcttgtg ttgctgtttc tctttggatg gctcggtaca gctgcttatt ccggcatgaa     1320

cgtgttgatt gttgatttga atctcaagtc tccggccacc gctaccgcag cgaataactt     1380

gatacgttgc atgttaggtg cattgggggc aatggttatt atgcctatca tcaacgctgt     1440

cggaatgggg tggacattta tcatgatttc aggggtttgg attgtattga gtcctctgat     1500

tatactcgtt gcgtggagca aaagtagtga gtag                                 1534


<210>  116
<211>  489
<212>  PRT
<213>  Talaromyces stipitatus

<400>  116

Met Thr Ala Ser Glu Gln Thr Ala Leu Leu Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Tyr Thr Ile Phe Ser Asn Ser Gln Lys Leu Leu Ile Ile Leu Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Ser Pro Leu Ser Ala Asn Ile Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Val Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Met Thr Ile Thr Ser Tyr Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Ile Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Leu Thr Phe 
            100                 105                 110         


Gln Thr Thr Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Val Asn Leu Ala Tyr Gly Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Tyr Val Gly Leu Ala Ser Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Val Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Tyr Gly Trp Arg Phe Ile Phe Val Val Leu Thr Gly Met Ala 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Ile Ile Val Phe Leu Pro Glu Thr Cys Arg 
        195                 200                 205             


Asn Ile Val Gly Asn Gly Ser Leu Glu Pro Leu Ser Val Trp Asn Lys 
    210                 215                 220                 


Pro Leu Ser Ser Phe Leu Cys Lys Lys Lys Glu Asn Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Ala Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Lys Ser Leu Thr Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Val Ile Leu Phe Asn Gly Phe Thr Phe Ala Thr Tyr Tyr 
        275                 280                 285             


Ala Val Thr Thr Ser Leu Thr Trp Cys Phe Ser Ser Thr Tyr His Phe 
    290                 295                 300                 


Asn Glu Val Glu Ile Gly Leu Ser Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Ala Val Lys Lys Val Leu Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Ile Val Ile Pro Ala Val Val Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Trp Ser Val Tyr Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Gly Thr Ala Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Ile Val Asp Leu Asn Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Leu Ile Arg Cys Met Leu Gly Ala Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Asn Ala Val Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Ile Met Ile Ser Gly Val Trp Ile Val Leu Ser Pro Leu Ile Ile 
465                 470                 475                 480 


Leu Val Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  117
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  117

Met Thr Ala Ser Glu Gln Thr Ala Leu Leu Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Tyr Thr Ile Phe Ser Asn Ser Gln Arg Leu Leu Ile Ile Leu Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Ser Pro Leu Ser Ala Asn Ile Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Val Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Met Thr Val Thr Ser Phe Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Ile Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Leu Thr Trp 
            100                 105                 110         


Gln Thr Thr Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Met Asn Leu Ala Tyr Gly Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Tyr Leu Gly Leu Ala Ser Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Leu Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Tyr Gly Trp Arg Phe Ile Phe Val Val Leu Thr Gly Val Ala 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Ile Ile Met Phe Leu Pro Glu Thr Cys Lys 
        195                 200                 205             


Asn Ile Val Gly Asn Gly Ser Leu Glu Pro Leu Ser Val Trp Asn Lys 
    210                 215                 220                 


Pro Leu Ser Ser Tyr Leu Cys Lys Lys Lys Glu Asn Glu Asp Leu Glu 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Ala Leu Glu Ala Ala Lys Arg Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Lys Ser Leu Thr Val Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Val Ile Leu Phe Asn Gly Phe Thr Phe Ala Thr Trp Tyr 
        275                 280                 285             


Gly Val Thr Thr Ser Leu Thr Trp Cys Phe Ser Ser Thr Tyr His Phe 
    290                 295                 300                 


Asn Glu Val Glu Ile Gly Leu Ser Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Ala Val Lys Lys Val Leu Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Leu Met Ile Pro Ala Val Val Leu Ala Met Leu Ala Val 
    370                 375                 380                 


Val Ala Tyr Gly Trp Ser Ile Tyr Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Gly Thr Ala Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Ile Val Asp Leu Asn Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Leu Ile Arg Cys Met Leu Gly Ala Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Gln Ala Val Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Ile Leu Ile Ser Gly Val Trp Ile Val Leu Ser Pro Leu Ile Ile 
465                 470                 475                 480 


Val Val Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  118
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  118

Met Thr Ala Ser Glu Gln Thr Ala Leu Met Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Tyr Thr Ile Phe Ser Asn Ser Gln Lys Leu Leu Val Ile Val Thr 
            20                  25                  30          


Ala Thr Leu Gly Ser Val Phe Ser Pro Val Ser Ala Asn Ile Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Val Ser Asp Glu Ile 
    50                  55                  60                  


Leu Asn Met Thr Ile Thr Ser Tyr Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Ile Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Leu Thr Phe 
            100                 105                 110         


Gln Thr Thr Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Val Asn Val Gly Tyr Gly Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Ser Ala Asp Arg Gly Arg Tyr Met Gly Leu Ala Ser Met Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Val Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Tyr Gly Trp Arg Tyr Ile Phe Val Val Leu Thr Gly Met Ala 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Ile Ile Val Phe Leu Pro Glu Thr Cys Lys 
        195                 200                 205             


Asn Ile Val Gly Asn Gly Ser Leu Glu Pro Leu Ser Val Trp Asn Lys 
    210                 215                 220                 


Pro Leu Ser Ser Phe Leu Cys Lys Lys Lys Glu Asn Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Asn Ala Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Lys Ser Leu Thr Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Val Ile Leu Phe Asn Gly Phe Thr Phe Ala Thr Phe Tyr 
        275                 280                 285             


Ala Leu Thr Ser Ser Leu Thr Trp Cys Phe Ser Ser Thr Tyr His Phe 
    290                 295                 300                 


Asn Glu Val Glu Val Gly Leu Ser Tyr Ile Pro Leu Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Ala Val Lys Lys Val Leu Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Ile Val Ile Pro Ala Val Val Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Tyr Ser Val Tyr Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Gly Thr Ala Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Ile Ile Asp Leu Asn Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Leu Ile Arg Cys Met Leu Gly Gly Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Asn Ala Ile Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Leu Met Ile Ser Gly Val Trp Ile Val Leu Ser Pro Met Ile Ile 
465                 470                 475                 480 


Leu Val Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  119
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  119

Met Thr Ala Ser Glu Gln Thr Ala Val Val Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Tyr Thr Ile Phe Ser Asn Ser Asn Arg Leu Ile Ile Ile Met Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Ser Pro Leu Ser Ala Asn Ile Tyr Tyr 
        35                  40                  45              


Pro Ala Ile Lys Ser Ile Gln Lys Asp Leu Asn Val Ser Glu Asp Ile 
    50                  55                  60                  


Leu Asn Met Thr Ile Thr Ser Tyr Leu Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Val Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Ile Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Met Thr Phe 
            100                 105                 110         


Gln Thr Thr Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Leu Asn Leu Ala Tyr Ala Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Thr Ala Glu Arg Gly Arg Tyr Val Gly Leu Ala Ser Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Val Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Tyr Gly Trp Arg Phe Ile Phe Val Val Leu Thr Gly Leu Ala 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Val Val Val Phe Leu Pro Glu Thr Cys Arg 
        195                 200                 205             


Asn Ile Val Gly Asn Gly Ser Leu Glu Pro Leu Ser Val Trp Asn Lys 
    210                 215                 220                 


Pro Val Ser Ser Phe Leu Cys Lys Lys Lys Glu Asn Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Ala Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Phe Lys Ser Leu Thr Met Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Leu Ile Leu Phe Asn Gly Phe Thr Phe Ala Thr Tyr Tyr 
        275                 280                 285             


Ala Val Thr Ser Ser Leu Thr Trp Cys Phe Ser Ser Thr Tyr His Phe 
    290                 295                 300                 


Asn Glu Val Glu Ile Gly Leu Ser Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Ala Val Lys Lys Leu Val Gly Arg Pro Ile Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Val Gln Ile Val Ile Pro Ala Leu Val Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Trp Ser Val Tyr Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Gly Thr Ala Ala Tyr Ser 
                405                 410                 415     


Gly Leu Asn Val Leu Ile Val Asp Ile Gln Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Leu Ile Arg Cys Met Leu Gly Gly Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Asn Ala Val Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Ile Met Leu Ser Gly Ile Trp Ile Val Leu Ser Pro Leu Ile Ile 
465                 470                 475                 480 


Leu Leu Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  120
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  120

Met Thr Ala Ser Glu Gln Thr Ala Leu Leu Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Gly Tyr Thr Val Phe Ser Asn Ser Gln Lys Leu Leu Ile Ile Leu Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Ser Pro Leu Ser Ala Asn Ile Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Val Ser Asp Glu Ile 
    50                  55                  60                  


Leu Asn Met Thr Ile Thr Ser Tyr Val Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Ile Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Leu Thr Phe 
            100                 105                 110         


Gln Thr Thr Phe Val Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Met Asn Val Ala Tyr Gly Val Thr Ala Glu Val 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Tyr Val Gly Leu Ala Thr Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Ile Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Phe Gly Trp Arg Phe Ile Phe Val Val Leu Thr Gly Leu Ala 
            180                 185                 190         


Leu Ile Ile Leu Ile Phe Ile Ile Leu Phe Ile Pro Glu Thr Cys Arg 
        195                 200                 205             


Asn Leu Val Ala Asn Gly Ser Leu Glu Pro Leu Thr Met Trp Asn Lys 
    210                 215                 220                 


Pro Leu Ser Ser Phe Leu Cys Lys Lys Lys Glu Asn Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Asn Ala Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Ala Lys Pro Lys Pro Trp Arg Ser Leu Thr Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Val Ile Leu Phe Asn Gly Phe Thr Tyr Ala Thr Phe Tyr 
        275                 280                 285             


Ala Val Thr Thr Ser Leu Thr Trp Cys Phe Ser Ser Thr Tyr His Phe 
    290                 295                 300                 


Asn Glu Val Glu Ile Gly Met Ser Tyr Ile Pro Met Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Ala Ile Lys Lys Val Leu Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Ile Val Ile Pro Ala Leu Val Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Trp Ser Val Tyr Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Met Phe Leu Tyr Gly Trp Leu Gly Thr Ala Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Ile Met Glu Leu Asn Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Leu Ile Arg Cys Met Leu Ala Ala Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Asn Ala Val Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Ile Met Ile Ser Gly Val Trp Ile Val Leu Ser Pro Ile Ile Ile 
465                 470                 475                 480 


Leu Ile Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  121
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  121

Met Thr Ala Ser Asp Asn Thr Ala Leu Leu Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Tyr Thr Leu Phe Ser Asn Ser Gln Lys Leu Leu Ile Ile Leu Thr 
            20                  25                  30          


Ala Thr Leu Gly Ser Val Phe Ser Pro Leu Ser Gly Asn Leu Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Thr Ile Gln Lys Glu Leu Asn Ile Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Val Thr Ile Thr Ser Tyr Val Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Leu Ile Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Leu Thr Phe 
            100                 105                 110         


Gln Thr Ser Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Leu Asn Leu Ala Tyr Gly Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Ser Ala Asp Arg Gly Arg Tyr Val Gly Leu Ala Ser Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Val Leu Gly Gly Val Ile Ser 
                165                 170                 175     


Gln Tyr Tyr Gly Trp Arg Phe Ile Phe Val Val Ile Thr Gly Met Ala 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Ile Ile Val Phe Leu Pro Glu Thr Cys Lys 
        195                 200                 205             


Asn Ile Val Gly Asn Gly Ser Leu Glu Pro Leu Ser Val Phe Asn Lys 
    210                 215                 220                 


Pro Leu Ser Ser Phe Ile Cys Lys Lys Lys Glu Asn Glu Asp Val Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Ala Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Lys Ser Leu Ser Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Leu Ile Leu Phe Asn Gly Phe Thr Phe Gly Thr Phe Tyr 
        275                 280                 285             


Ala Val Ser Thr Ser Leu Thr Trp Cys Phe Ser Ser Thr Phe His Tyr 
    290                 295                 300                 


Asn Asp Val Asp Ile Gly Leu Thr Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Ala Val Lys Lys Leu Leu Gly Arg Pro Ile Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Trp His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Leu Val Leu Pro Ala Leu Val Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Phe Ser Val Trp Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Gly Thr Ala Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Ile Val Asp Leu Asn Leu Arg Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Leu Met Arg Cys Met Leu Gly Ala Leu Gly 
        435                 440                 445             


Ala Leu Val Ile Met Pro Ile Met Asn Ala Val Gly Ile Gly Trp Thr 
    450                 455                 460                 


Phe Ile Met Ile Ser Gly Leu Phe Ile Val Leu Ser Pro Val Val Ile 
465                 470                 475                 480 


Leu Val Ala Phe Ser Lys Ser Thr Glu 
                485                 


<210>  122
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  122

Met Thr Ala Ser Glu Gln Ser Ala Leu Ile Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Tyr Thr Ile Tyr Ser Asn Ser Gln Arg Leu Leu Ile Ile Leu Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Thr Pro Leu Ser Ala Gln Ile Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Val Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Met Thr Ile Thr Ser Tyr Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Thr Leu Ser Asp Thr Ile Gly Lys Arg Pro Val Tyr 
                85                  90                  95      


Leu Ile Cys Phe Leu Ile Trp Ile Ala Ala Asn Val Gly Leu Thr Phe 
            100                 105                 110         


Gln Thr Ser Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Val Asn Ile Ala Tyr Gly Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Tyr Val Gly Val Ala Thr Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Leu Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Phe Gly Trp Arg Trp Ile Phe Val Val Ile Thr Gly Met Ala 
            180                 185                 190         


Leu Ile Ile Leu Ile Phe Ile Ile Val Trp Met Pro Glu Thr Cys Arg 
        195                 200                 205             


Gln Ile Val Ala Asn Gly Ser Ile Glu Pro Leu Ser Val Trp Asn Arg 
    210                 215                 220                 


Pro Leu Ser Ser Phe Met Cys Lys Lys Lys Glu Asn Asp Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Ala Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Lys Ser Leu Thr Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Val Ile Leu Phe Asn Gly Phe Thr Phe Ala Thr Phe Tyr 
        275                 280                 285             


Ala Val Thr Ser Ser Ile Thr Trp Cys Phe Ser Ser Ser Phe His Phe 
    290                 295                 300                 


Asn Glu Val Glu Ile Gly Leu Ser Tyr Ile Pro Ile Ala Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Val Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Gly Leu Lys Lys Val Val Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Ser 
        355                 360                 365             


Arg Leu Gln Leu Val Ile Pro Ala Val Val Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Trp Ser Val Tyr Leu Val Leu Thr Pro Ala Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Gly Ser Ala Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Leu Val Asp Leu Asn Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Val Ile Arg Cys Met Leu Ala Ala Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Asn Ala Val Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Ile Met Ile Ser Gly Leu Phe Ile Val Leu Ser Pro Val Ile Val 
465                 470                 475                 480 


Leu Leu Ala Tyr Ser Lys Ser Ser Glu 
                485                 


<210>  123
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  123

Met Thr Ala Ser Glu Gln Thr Ala Ile Leu Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Phe Thr Ile Phe Ser Asn Ser Gln Arg Leu Val Ile Ile Val Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Ser Pro Leu Ser Ala Asn Leu Tyr Tyr 
        35                  40                  45              


Pro Ala Val Lys Ser Ile Gln Lys Glu Leu Asn Leu Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Met Thr Ile Thr Ser Tyr Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Leu Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Leu Thr Phe 
            100                 105                 110         


Gln Thr Thr Phe Val Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Ile Asn Leu Ala Tyr Gly Val Thr Ala Glu Val 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Tyr Val Gly Leu Ala Ser Val Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Val Leu Gly Gly Ile Ile Ser 
                165                 170                 175     


Gln Tyr Tyr Gly Trp Arg Phe Ile Phe Val Val Val Thr Gly Met Ala 
            180                 185                 190         


Leu Ile Ile Leu Ile Phe Val Ile Leu Phe Val Pro Glu Thr Cys Arg 
        195                 200                 205             


Asn Leu Val Gly Asn Gly Ser Leu Asp Pro Leu Ser Val Trp Asn Lys 
    210                 215                 220                 


Pro Leu Ser Ser Phe Met Cys Lys Lys Arg Glu Asn Asp Glu Leu Asp 
225                 230                 235                 240 


Glu Ser Leu Glu Ala Gln Asn Ala Ile Asp Ala Ala Arg Lys Lys Ala 
                245                 250                 255     


Gly Arg Pro Lys Pro Phe Arg Ser Leu Thr Val Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Leu Leu Leu Phe Asn Gly Phe Thr Tyr Ala Thr Tyr Phe 
        275                 280                 285             


Ala Leu Thr Thr Ser Leu Thr Trp Cys Phe Ser Ser Thr Tyr His Phe 
    290                 295                 300                 


Asn Glu Val Asp Ile Gly Leu Ser Tyr Ile Pro Ile Gly Val Gly Thr 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Arg 
                325                 330                 335     


Arg Gly Leu Lys Arg Ile Leu Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Ile Ile Leu Pro Ala Ile Ile Leu Ala Met Leu Ala Met 
    370                 375                 380                 


Val Ala Tyr Gly Phe Thr Ile Tyr Leu Leu Val Thr Pro Ala Val Pro 
385                 390                 395                 400 


Val Val Leu Ile Phe Leu Phe Gly Trp Leu Gly Thr Ala Ala Phe Thr 
                405                 410                 415     


Gly Val Asn Val Val Ile Leu Asp Leu Asn Leu Arg Ser Pro Ala Ser 
            420                 425                 430         


Ala Ser Ala Ala Asn Asn Met Leu Arg Cys Met Leu Gly Ala Leu Gly 
        435                 440                 445             


Ala Met Val Val Met Pro Ile Val Asn Ala Val Gly Leu Gly Tyr Thr 
    450                 455                 460                 


Phe Val Leu Ile Ser Gly Leu Trp Ile Val Leu Ser Pro Val Val Ile 
465                 470                 475                 480 


Leu Leu Ala Trp Thr Lys Ser Ser Glu 
                485                 


<210>  124
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  124

Met Thr Ala Ser Glu Gln Thr Ala Met Ile Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Ala Trp Thr Ile Phe Thr Gln Ser Gln Arg Leu Leu Leu Ile Ile Thr 
            20                  25                  30          


Ala Thr Leu Gly Thr Val Phe Ser Pro Leu Ser Ala Asn Val Tyr Tyr 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Leu Ser Glu Glu Met 
    50                  55                  60                  


Leu Asn Leu Thr Ile Thr Ser Tyr Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Ile Gly Ser Leu Ser Asp Thr Ile Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Ile Leu Cys Phe Leu Ile Tyr Ile Ala Ala Asn Val Gly Ile Thr Phe 
            100                 105                 110         


Gln Thr Ser Phe Ile Ala Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Ile Asn Leu Ala Tyr Gly Val Thr Ala Asp Val 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Tyr Leu Gly Val Ala Ser Met Ala 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Ile Leu Gly Gly Val Ile Ser 
                165                 170                 175     


Asn Tyr Tyr Gly Trp Arg Phe Val Phe Leu Val Val Thr Gly Leu Gly 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Leu Leu Leu Phe Leu Pro Glu Thr Cys Arg 
        195                 200                 205             


Asn Leu Val Gly Asn Gly Ser Val Glu Pro Leu Ser Leu Trp Asn Lys 
    210                 215                 220                 


Pro Val Ser Ser Phe Leu Cys Lys Lys Lys Glu Asn Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Gly Ile Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Lys Ser Leu Ser Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Leu Leu Leu Tyr Asn Gly Phe Thr Phe Ala Thr Tyr Tyr 
        275                 280                 285             


Ala Leu Thr Thr Ser Leu Thr Phe Cys Phe Ser Ser Thr Tyr His Tyr 
    290                 295                 300                 


Asn Glu Val Asp Ile Gly Leu Ser Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Lys 
                325                 330                 335     


Arg Ala Val Lys Lys Val Met Gly Arg Pro Leu Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Ile Ile Ile Pro Ala Leu Leu Leu Ala Met Leu Ala Leu 
    370                 375                 380                 


Val Ala Tyr Gly Trp Thr Ile Tyr Val Val Leu Ser Pro Gly Val Pro 
385                 390                 395                 400 


Val Val Val Ile Phe Leu Phe Gly Trp Leu Gly Thr Gly Ala Tyr Ser 
                405                 410                 415     


Gly Met Asn Val Leu Leu Val Asp Leu Asn Leu Lys Ser Pro Ala Ser 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Val Ile Arg Cys Met Leu Ala Ala Leu Gly 
        435                 440                 445             


Ala Met Val Leu Met Pro Ile Ile Gln Ala Val Gly Val Ala Trp Thr 
    450                 455                 460                 


Phe Ile Leu Ile Ser Gly Val Trp Ile Val Leu Ser Pro Leu Ile Leu 
465                 470                 475                 480 


Leu Val Gly Trp Ser Lys Ser Ser Asp 
                485                 


<210>  125
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  125

Met Thr Ala Ser Glu Gln Thr Ala Leu Val Gly Ser Pro Arg Arg Pro 
1               5                   10                  15      


Ala Tyr Ser Met Phe Thr Asn Ser Gln Lys Met Leu Ile Ile Val Thr 
            20                  25                  30          


Ala Thr Leu Ala Ser Val Phe Ser Pro Ile Ser Gly Gln Leu Phe Tyr 
        35                  40                  45              


Pro Ala Met Lys Ser Ile Gln Lys Glu Leu Asn Met Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Leu Thr Met Thr Ser Phe Leu Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Leu Gly Ser Leu Ser Asp Thr Met Gly Arg Arg Pro Val Tyr 
                85                  90                  95      


Leu Ile Cys Phe Leu Ile Phe Ile Ala Ala Asn Val Gly Met Thr Phe 
            100                 105                 110         


Gln Thr Thr Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Ile Asn Leu Gly Tyr Gly Val Thr Ala Glu Val 
    130                 135                 140                 


Val Ser Ser Ala Glu Arg Gly Arg Phe Leu Gly Ile Ala Ser Leu Gly 
145                 150                 155                 160 


Pro Ile Ile Gly Pro Thr Leu Gly Pro Leu Leu Gly Gly Met Ile Thr 
                165                 170                 175     


Gln Trp Tyr Gly Trp Arg Trp Ile Phe Leu Val Val Thr Gly Met Ala 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Ile Ile Val Phe Leu Pro Glu Ser Cys Arg 
        195                 200                 205             


Asn Ile Ile Ala Gln Gly Ser Leu Glu Pro Ile Ser Val Trp Asn Arg 
    210                 215                 220                 


Pro Met Ser Thr Tyr Val Cys Lys Lys Lys Asp Asn Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Thr Leu Glu Ala Gln Gln Ala Leu Glu Ala Ala Arg Lys Lys Gly 
                245                 250                 255     


Gly Lys Pro Lys Pro Phe Arg Thr Leu Thr Val Leu Phe Ser Tyr Pro 
            260                 265                 270         


Thr Gly Cys Leu Met Leu Tyr Asn Gly Phe Ser Phe Gly Thr Tyr Tyr 
        275                 280                 285             


Ala Leu Thr Thr Ser Ile Thr Trp Cys Phe Ser Ser Thr Tyr His Trp 
    290                 295                 300                 


Asn Glu Val Glu Ile Gly Leu Thr Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Phe Leu Leu Asp Trp Asn Tyr Lys 
                325                 330                 335     


Arg Ala Met Arg Lys Val Ile Gly Arg Pro Leu Gly Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Ile Glu Arg Ser 
        355                 360                 365             


Arg Val Gln Ile Leu Ile Pro Ala Ile Val Leu Ala Met Leu Ala Val 
    370                 375                 380                 


Val Ala Phe Gly Phe Thr Leu Phe Leu Val Leu Ser Pro Gly Val Pro 
385                 390                 395                 400 


Leu Val Leu Leu Phe Leu Phe Gly Trp Leu Ala Thr Ala Ala Phe Ser 
                405                 410                 415     


Gly Met Asn Ile Ile Met Val Asp Ile Asn Leu Lys Ser Pro Ala Ser 
            420                 425                 430         


Ala Thr Ala Ala Asn Asn Val Ile Arg Cys Met Leu Gly Ala Leu Gly 
        435                 440                 445             


Ala Val Val Leu Met Pro Ile Leu Gln Gly Val Gly Met Gly Trp Thr 
    450                 455                 460                 


Phe Ile Ile Ile Ser Gly Val Trp Ile Val Leu Ser Pro Ile Val Leu 
465                 470                 475                 480 


Leu Val Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  126
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 116

<400>  126

Met Ser Ala Ser Glu Gln Ser Ala Val Ile Gly Ser Pro Arg Lys Pro 
1               5                   10                  15      


Gly Trp Thr Val Tyr Thr Asn Ser Gln Lys Ile Val Val Ile Leu Thr 
            20                  25                  30          


Ala Ser Leu Ala Ser Val Phe Ser Pro Met Ser Ala Asn Ile Tyr Trp 
        35                  40                  45              


Pro Ala Leu Lys Ser Ile Gln Lys Glu Leu Asn Leu Ser Glu Glu Ile 
    50                  55                  60                  


Leu Asn Leu Thr Ile Thr Ser Tyr Met Ile Phe Gln Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Phe Val Gly Ser Leu Ser Asp Thr Val Gly Arg Arg Pro Leu Tyr 
                85                  90                  95      


Leu Leu Cys Phe Leu Ile Tyr Ile Ala Ala Gln Val Gly Met Thr Phe 
            100                 105                 110         


Gln Ser Ser Phe Ile Gly Leu Leu Leu Leu Arg Cys Leu Gln Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Thr Val Asn Leu Gly Tyr Ala Val Thr Ala Glu Met 
    130                 135                 140                 


Val Thr Ser Ala Glu Arg Gly Arg Trp Val Gly Val Ala Ser Val Gly 
145                 150                 155                 160 


Pro Leu Ile Gly Pro Thr Leu Gly Pro Leu Leu Gly Gly Leu Ile Ser 
                165                 170                 175     


Gln Tyr Phe Gly Trp Arg Tyr Ile Phe Val Val Val Thr Gly Leu Gly 
            180                 185                 190         


Leu Ile Met Leu Ile Phe Val Leu Leu Phe Leu Pro Glu Thr Cys Arg 
        195                 200                 205             


Asn Leu Leu Gly Asn Gly Ser Val Glu Pro Leu Thr Val Trp Asn Lys 
    210                 215                 220                 


Pro Leu Ser Thr Trp Leu Cys Lys Lys Lys Glu Asn Glu Glu Leu Asp 
225                 230                 235                 240 


Asp Thr Ile Asp Ala Gln Gln Ala Val Glu Ala Ala Arg Lys Lys Ala 
                245                 250                 255     


Gly Lys Pro Lys Pro Trp Arg Thr Leu Thr Leu Leu Phe Thr Tyr Pro 
            260                 265                 270         


Thr Gly Cys Val Ile Leu Phe Asn Gly Phe Ser Phe Ala Thr Tyr Phe 
        275                 280                 285             


Ala Met Thr Thr Ser Val Thr Trp Cys Phe Ser Thr Ser Phe His Phe 
    290                 295                 300                 


Asn Glu Val Glu Leu Gly Leu Ser Tyr Ile Pro Ile Gly Val Gly Ser 
305                 310                 315                 320 


Met Ile Ala Ala Phe Thr Asn Gly Tyr Leu Leu Asp Trp Asn Tyr Lys 
                325                 330                 335     


Arg Gly Val Lys Lys Val Met Gly Arg Pro Ile Ala Arg Gly Glu His 
            340                 345                 350         


Phe Asp His Asp Thr Gly Val Ala Leu Gly Phe His Leu Glu Arg Thr 
        355                 360                 365             


Arg Leu Gln Ile Met Val Pro Ala Ile Val Leu Ala Met Leu Ala Leu 
    370                 375                 380                 


Val Ala Phe Gly Trp Ser Ile Tyr Met Leu Leu Thr Pro Ala Leu Pro 
385                 390                 395                 400 


Leu Val Val Ile Phe Leu Phe Gly Trp Leu Gly Thr Ala Gly Trp Ser 
                405                 410                 415     


Gly Met Asn Leu Leu Ile Met Glu Leu Asn Leu Lys Ser Pro Ala Thr 
            420                 425                 430         


Ala Thr Ala Ala Gln Asn Leu Leu Arg Cys Met Leu Gly Ala Leu Gly 
        435                 440                 445             


Ala Met Val Ile Met Pro Ile Ile Asn Ala Leu Gly Met Ala Trp Thr 
    450                 455                 460                 


Phe Leu Ile Leu Ser Gly Val Trp Ile Val Leu Ser Pro Ile Leu Leu 
465                 470                 475                 480 


Leu Leu Ala Trp Ser Lys Ser Ser Glu 
                485                 


<210>  127
<211>  1599
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  127
atgccctccg ccagcgagac cactcccctt ctcggggagg accagtgccc aaaatcatcc       60

cagggggcca tcgtcccaga cttcaagcca ccccaagatg agctgaaagc acatagcatt      120

ttcacacggc cacaaaagat cctgatcgtc atcatcgcct ccctggctgc cttcttctcc      180

ccggtttcgt cggccattta cttcccggcg ctgggcacct tggccgatgc cctcggagtg      240

tctgtctcgt tgatcaacct caccgtgacc acgtatctgg taacgtagga ccctacatga      300

tccctctatt gttctcccgc tgaccgactt ccccaggtca tgcaagggct ggcgccctcc      360

ttcattggga gctggtccga tcgagcgggg cgacggccgc tctacatcgc gtgcttcgtc      420

atctacattg gatccaacat tggactggcc ctccagacca actacgtggc tttactgatc      480

ctgcgaatgg tccagagcgc gggcagcagt ccgttggtgt ccctggccca ggcagtcgtt      540

gcggacatgg cgacctccgc cgaacgaggc cgttatatca gctatgtcac ctccggggcc      600

atcctgggcc cggctgtggg accgttgatc ggaggcatgc tgatccagtc gtttggctgg      660

cggtcggtct tttggttcct ggccatcttc gcgggcgtcg tctttctcct catgctcgcc      720

tgcctgcccg agacctgtcg cgccgtcgtg ggagatggct cgattccccc tcccacctgg      780

atccatatgt cctggctggc atatcgacac cgacgacaaa tacccctaaa cggccccccg      840

atgaccatct ccacgagtcc agcagccatt cgacccggac gcaaggccag cccgaccgga      900

tccctccgcg tgatcgccga ccgggaaacc agcctgatcc tgatctacgc cggctgcgtg      960

ctggccgggt accaaatggt gtccgcgaat ctgtcggagg cactctcggc gcagtacgcc     1020

ttcaacacct tccaggtggg cttgtgcttc ctgcccttcg gcgccggggc tttcctggcg     1080

accctcacga ccggccacat cgtcgactgg aacttccggc gcttggcgcg catccaccac     1140

ctggacctcc gccagggccg ccagcaggat ctgtcccagt tcccgatcga aaaggcgcgg     1200

ctgcaggtcg gcatgccgat tgtcggggtc ggcgccctgt cggtgctggt gtacggctgg     1260

acgatgcaag cgcgcacccc tctggccgtg ccgctggtgg cgctgttcgt ggtgggctgg     1320

acggtcagca gctcgaccaa ctcgatctcg gtcctcatcg tcgatctgca tctggacacg     1380

ccggcgaccg cgacggcggc gaataatctg gtgcggtgct ggatgggggc gctggcggtg     1440

gccgtgatgg ggccggccgt cgaggcgatc gggatcggat ggatggggac ggtgatatgc     1500

gccgtctata tcggcctgtt gcccatgctg atgctggtgt ggaggaaagg gccgacatgg     1560

cggagggaga agagagaaaa atggccgatg atgacttga                            1599


<210>  128
<211>  513
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  128

Met Pro Ser Ala Ser Glu Thr Thr Pro Leu Leu Gly Glu Asp Gln Cys 
1               5                   10                  15      


Pro Lys Ser Ser Gln Gly Ala Ile Val Pro Asp Phe Lys Pro Pro Gln 
            20                  25                  30          


Asp Glu Leu Lys Ala His Ser Ile Phe Thr Arg Pro Gln Lys Ile Leu 
        35                  40                  45              


Ile Val Ile Ile Ala Ser Leu Ala Ala Phe Phe Ser Pro Val Ser Ser 
    50                  55                  60                  


Ala Ile Tyr Phe Pro Ala Leu Gly Thr Leu Ala Asp Ala Leu Gly Val 
65                  70                  75                  80  


Ser Val Ser Leu Ile Asn Leu Thr Val Thr Thr Tyr Leu Val Met Gln 
                85                  90                  95      


Gly Leu Ala Pro Ser Phe Ile Gly Ser Trp Ser Asp Arg Ala Gly Arg 
            100                 105                 110         


Arg Pro Leu Tyr Ile Ala Cys Phe Val Ile Tyr Ile Gly Ser Asn Ile 
        115                 120                 125             


Gly Leu Ala Leu Gln Thr Asn Tyr Val Ala Leu Leu Ile Leu Arg Met 
    130                 135                 140                 


Val Gln Ser Ala Gly Ser Ser Pro Leu Val Ser Leu Ala Gln Ala Val 
145                 150                 155                 160 


Val Ala Asp Met Ala Thr Ser Ala Glu Arg Gly Arg Tyr Ile Ser Tyr 
                165                 170                 175     


Val Thr Ser Gly Ala Ile Leu Gly Pro Ala Val Gly Pro Leu Ile Gly 
            180                 185                 190         


Gly Met Leu Ile Gln Ser Phe Gly Trp Arg Ser Val Phe Trp Phe Leu 
        195                 200                 205             


Ala Ile Phe Ala Gly Val Val Phe Leu Leu Met Leu Ala Cys Leu Pro 
    210                 215                 220                 


Glu Thr Cys Arg Ala Val Val Gly Asp Gly Ser Ile Pro Pro Pro Thr 
225                 230                 235                 240 


Trp Ile His Met Ser Trp Leu Ala Tyr Arg His Arg Arg Gln Ile Pro 
                245                 250                 255     


Leu Asn Gly Pro Pro Met Thr Ile Ser Thr Ser Pro Ala Ala Ile Arg 
            260                 265                 270         


Pro Gly Arg Lys Ala Ser Pro Thr Gly Ser Leu Arg Val Ile Ala Asp 
        275                 280                 285             


Arg Glu Thr Ser Leu Ile Leu Ile Tyr Ala Gly Cys Val Leu Ala Gly 
    290                 295                 300                 


Tyr Gln Met Val Ser Ala Asn Leu Ser Glu Ala Leu Ser Ala Gln Tyr 
305                 310                 315                 320 


Ala Phe Asn Thr Phe Gln Val Gly Leu Cys Phe Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Ala Phe Leu Ala Thr Leu Thr Thr Gly His Ile Val Asp Trp Asn 
            340                 345                 350         


Phe Arg Arg Leu Ala Arg Ile His His Leu Asp Leu Arg Gln Gly Arg 
        355                 360                 365             


Gln Gln Asp Leu Ser Gln Phe Pro Ile Glu Lys Ala Arg Leu Gln Val 
    370                 375                 380                 


Gly Met Pro Ile Val Gly Val Gly Ala Leu Ser Val Leu Val Tyr Gly 
385                 390                 395                 400 


Trp Thr Met Gln Ala Arg Thr Pro Leu Ala Val Pro Leu Val Ala Leu 
                405                 410                 415     


Phe Val Val Gly Trp Thr Val Ser Ser Ser Thr Asn Ser Ile Ser Val 
            420                 425                 430         


Leu Ile Val Asp Leu His Leu Asp Thr Pro Ala Thr Ala Thr Ala Ala 
        435                 440                 445             


Asn Asn Leu Val Arg Cys Trp Met Gly Ala Leu Ala Val Ala Val Met 
    450                 455                 460                 


Gly Pro Ala Val Glu Ala Ile Gly Ile Gly Trp Met Gly Thr Val Ile 
465                 470                 475                 480 


Cys Ala Val Tyr Ile Gly Leu Leu Pro Met Leu Met Leu Val Trp Arg 
                485                 490                 495     


Lys Gly Pro Thr Trp Arg Arg Glu Lys Arg Glu Lys Trp Pro Met Met 
            500                 505                 510         


Thr 
    


<210>  129
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 128

<400>  129

Met Pro Ser Ala Ser Glu Glu Leu Pro Leu Leu Gly Glu Asp Gln Met 
1               5                   10                  15      


Pro Lys Ser Ser Gln Ile Ala Ile Val Pro Asp Phe Lys Pro Pro Gln 
            20                  25                  30          


Asp Glu Leu Lys Ala His Ser Ile Phe Cys Arg Pro Gln Lys Ile Leu 
        35                  40                  45              


Ile Val Ile Ile Ala Ser Leu Ala Ala Phe Phe Thr Pro Val Ser Ser 
    50                  55                  60                  


Ala Ile Tyr Phe Pro Ala Leu Gly Pro Leu Ala Asp Ala Leu Gly Val 
65                  70                  75                  80  


Ser Val Ser Leu Ile Asn Leu Thr Val Thr Thr Tyr Leu Val Met Gln 
                85                  90                  95      


Gly Leu Ala Pro Ser Phe Ile Gly Ser Trp Ser Asp Arg Ala Gly Arg 
            100                 105                 110         


Arg Pro Leu Tyr Ile Ala Cys Phe Val Ile Tyr Ile Gly Ser Asn Ile 
        115                 120                 125             


Gly Leu Ala Leu Gln Thr Asn Tyr Val Ala Leu Leu Ile Leu Arg Met 
    130                 135                 140                 


Val Gln Ser Ala Gly Ser Ser Pro Leu Val Ser Leu Ala Gln Ala Val 
145                 150                 155                 160 


Val Ala Asp Met Ala Thr Ser Ala Glu Arg Gly Arg Tyr Ile Ser Tyr 
                165                 170                 175     


Val Thr Ser Gly Ala Ile Leu Gly Pro Ala Val Gly Pro Leu Ile Gly 
            180                 185                 190         


Gly Met Leu Ile Gln Ser Gln Gly Trp Arg Ser Val Phe Trp Phe Leu 
        195                 200                 205             


Ala Ile Phe Ala Gly Val Val Phe Leu Leu Met Leu Ala Cys Leu Pro 
    210                 215                 220                 


Glu Thr Cys Arg Asp Val Val Gly Lys Gly Ser Lys Pro Pro Pro Thr 
225                 230                 235                 240 


Trp Ile His Met Ser Trp Leu Gln Tyr Arg Lys Arg Arg Gln Ile Pro 
                245                 250                 255     


Leu Asn Gly Pro Pro Met Thr Glu Ser Thr Ile Pro Ala Ala Ile Arg 
            260                 265                 270         


Pro Gly Arg Lys Ala Ser Pro Thr Gly Pro Leu Arg Val Ile Ala Asp 
        275                 280                 285             


Arg Glu Thr Ser Leu Ile Leu Ile Tyr Ala Gly Cys Val Leu Ala Gly 
    290                 295                 300                 


Tyr Gln Met Val Ser Ala Asn Leu Ser Glu Ala Leu Ser Ala Gly Tyr 
305                 310                 315                 320 


Ala Phe Asn Thr Phe Gln Val Gly Leu Cys Phe Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Ala Phe Leu Ala Thr Leu Thr Thr Gly His Ile Val Asp Trp Asn 
            340                 345                 350         


Phe Arg Arg Leu Ala Arg Ile His His Thr Asp Leu Arg Gln Gly Arg 
        355                 360                 365             


Gln Gln Asp Leu Ser Gln Phe Pro Arg Glu Lys Ala Arg Leu Leu Val 
    370                 375                 380                 


Gly Met Pro Ile Val Gly Val Gly Ala Leu Ser Val Leu Val Tyr Gly 
385                 390                 395                 400 


Trp Thr Met Ser Ala Thr Thr Pro Leu Ala Val Pro Leu Val Ala Leu 
                405                 410                 415     


Phe Val Val Gly Trp Thr Val Ser Ser Ser Thr Asn Ser Ile Ser Val 
            420                 425                 430         


Leu Ile Val Asp Leu His Leu Asp Thr Pro Ala Thr Ala Thr Ala Ala 
        435                 440                 445             


Asn Asn Leu Val Arg Cys Trp Met Gly Ala Leu Ala Val Ala Val Met 
    450                 455                 460                 


Gly Pro Ala Val Glu Ala Ile Gly Ile Gly Thr Met Gly Thr Val Ile 
465                 470                 475                 480 


Cys Ala Val Tyr Ile Gly Leu Leu Pro Met Leu Met Leu Val Trp Gly 
                485                 490                 495     


Lys Gly Pro Thr Trp Arg Arg Met Lys Arg Glu Arg Trp Pro Met Met 
            500                 505                 510         


Thr 
    


<210>  130
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 128

<400>  130

Met Pro Ser Ala Ser Glu Glu Thr Pro Leu Leu Gly Glu Asp Gln Cys 
1               5                   10                  15      


Pro Lys Ser Ser Gln Gly Val Ile Val Pro Val Phe Lys Asn Pro Gln 
            20                  25                  30          


Asp Glu Leu Lys Ala His Gln Ile Phe Thr Arg Pro Gln Lys Ile Leu 
        35                  40                  45              


Ile Val Ile Ile Ala Ser Leu Ala Gly Phe Phe Ser Pro Val Ser Ser 
    50                  55                  60                  


Thr Ile Tyr Phe Pro Ala Leu Gly Thr Leu Ala Asp Ala Leu Gly Val 
65                  70                  75                  80  


Ser Val Thr Leu Ile Asn Leu Thr Val Thr Thr Tyr Leu Val Met Gln 
                85                  90                  95      


Gly Leu Ala Pro Ser Phe Ile Gly Ser Trp Ser Asp Arg Ala Gly Arg 
            100                 105                 110         


Arg Pro Leu Tyr Ile Ala Cys Phe Val Ile Tyr Ile Gly Ser Asn Ile 
        115                 120                 125             


Gly Leu Ala Leu Gln Thr Asn Tyr Val Ala Leu Leu Ile Leu Arg Met 
    130                 135                 140                 


Val Gln Ser Ala Gly Ser Ser Pro Leu Val Ser Leu Ala Glu Ala Val 
145                 150                 155                 160 


Val Ala Asp Met Ala Thr Ser Ala Glu Arg Gly Arg Tyr Ile Ser Tyr 
                165                 170                 175     


Val Thr Ser Gly Ala Ile Leu Gly Pro Ala Val Gly Pro Leu Ile Gly 
            180                 185                 190         


Gly Met Leu Ile Gln Ser Phe Gly Trp Arg Ser Val Phe Trp Phe Leu 
        195                 200                 205             


Ala Ile Phe Ala Gly Val Val Phe Leu Leu Met Leu Ala Cys Leu Pro 
    210                 215                 220                 


Glu Thr Cys Arg Ala Val Val Gly Asp Gly Ser Ile Pro Pro Pro Thr 
225                 230                 235                 240 


Trp Tyr His Met Ser Trp Met Ala Tyr Arg His Ser Arg Gln Asn Pro 
                245                 250                 255     


Leu Pro Gly Pro Pro Met Thr Ile Ser Thr Ser Pro Ala Ala Ile Arg 
            260                 265                 270         


Pro Gln Val Lys Ala Ser Pro Thr Gly Ser Leu Arg Val Ile Ala Asp 
        275                 280                 285             


Arg Glu Thr Ser Leu Ile Leu Ile Tyr Ala Gly Cys Val Leu Ala Gly 
    290                 295                 300                 


Leu Gln Met Val Ser Ala Asn Leu Ser Glu Ala Leu Ser Ala Asp Tyr 
305                 310                 315                 320 


Ala Phe Asn Val Phe Gln Val Gly Leu Cys Phe Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Met Phe Leu Ala Thr Leu Thr Thr Gly His Ile Val Asp Trp Asn 
            340                 345                 350         


Phe Arg Arg Leu Leu Arg Ile His His Leu Asp Leu Arg Gln Gly Arg 
        355                 360                 365             


Gln Gln Asp Leu Ser Gln Phe Pro Ile Glu Lys Ala Arg Leu Tyr Val 
    370                 375                 380                 


Gly Met Pro Ile Val Gly Val Gly Ala Leu Ser Val Leu Val Tyr Gly 
385                 390                 395                 400 


Trp Thr Met Gln Ala Arg Thr Pro Leu Ala Val Pro Leu Val Ala Leu 
                405                 410                 415     


Phe Val Val Gly Trp Thr Val Ser Ser Ser Val Asn Ser Ile Ser Val 
            420                 425                 430         


Leu Ile Val Asp Leu His Leu Asp Thr Ser Ala Thr Ala Thr Ala Ala 
        435                 440                 445             


Asn Asn Leu Val Arg Thr Trp Met Gly Ala Leu Ala Val Ala Val Met 
    450                 455                 460                 


Gly Pro Ala Val Glu Ala Ile Gly Ile Gly Trp Met Gly Thr Val Ile 
465                 470                 475                 480 


Cys Ala Val Tyr Ile Gly Leu Leu Pro Met Leu Met Leu Val Trp Arg 
                485                 490                 495     


Lys Gly Pro Thr Trp Arg Arg Glu Lys Arg Glu Lys Trp Pro Ile Met 
            500                 505                 510         


Thr 
    


<210>  131
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 128

<400>  131

Met Pro Ser Ala Ser Glu Thr Thr Pro Leu Leu Gly Glu Val Gln Cys 
1               5                   10                  15      


Pro Lys Thr Lys Gln Ala Ala Ile Val Pro Glu Phe Lys Pro Pro Gln 
            20                  25                  30          


Ala Glu Arg Lys Ala His Ser Ile Phe Thr Arg Pro Gln Lys Ile Leu 
        35                  40                  45              


Ile Val Ile Ile Ala Ser Leu Ala Ala Phe Phe Ser Ser Val Ser Ser 
    50                  55                  60                  


Ala Ile Tyr Phe Pro Ala Leu Gly Thr Leu Ala Asp Ala Leu Gly Val 
65                  70                  75                  80  


Ser Val Ser Leu Ile Asn Leu Thr Val Thr Thr Tyr Leu Val Met Gln 
                85                  90                  95      


Gly Leu Ala Pro Ser Phe Ile Gly Ser Trp Ser Asp Arg Ala Gly Arg 
            100                 105                 110         


Arg Pro Leu Tyr Ile Ala Cys Phe Val Ile Ala Ile Gly Ser Asn Ile 
        115                 120                 125             


Gly Ile Ala Leu Gln Thr Asn Tyr Val Ala Leu Leu Ile Leu Arg Met 
    130                 135                 140                 


Val Gln Ser Ala Gly Thr Ser Pro Leu Val Ser Leu Ala Gln Ala Val 
145                 150                 155                 160 


Val Ala Asp His Ala Thr Ser Ala Glu Arg Gly Arg Tyr Ile Ser Tyr 
                165                 170                 175     


Val Pro Ser Gly Ala Ile Leu Gly Pro Ala Val Gly Pro Leu Ile Gly 
            180                 185                 190         


Gly Met Leu Ile Gln Ser Phe Gly Trp Arg Ser Val Phe Trp Phe Leu 
        195                 200                 205             


Ala Ile Phe Ala Gly Val Val Phe Leu Leu Met Leu Ala Cys Leu Pro 
    210                 215                 220                 


Glu Gly Cys Arg Ala Gln Val Gly Asp Gly Ser Ile Asp Pro Pro Thr 
225                 230                 235                 240 


Trp Ile His Met Ser Trp Ala Tyr Tyr Arg His Arg Arg Gln Ile Pro 
                245                 250                 255     


Leu Asn Gly Pro Pro Met Ser Ile Ser Thr Ser Lys Ala Ala Leu Arg 
            260                 265                 270         


Pro Gly Arg His Ala Ser Pro Thr Gly Ser Leu Arg Val Ile Ala Asp 
        275                 280                 285             


Arg Arg Thr Ser Leu Ile Leu Ile Tyr Ala Gly Cys Val Leu Ala Gly 
    290                 295                 300                 


Tyr Gln Met Val Ser Ala Asn Leu Ser Glu Ala Leu Ser Ala Gln Tyr 
305                 310                 315                 320 


Ala Phe Asn Thr Phe Gln Val Gly Leu Cys Phe Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Ala Phe Leu Ala Ser Leu Thr Thr Gly Val Ile Val Asp Trp Asn 
            340                 345                 350         


Phe Arg Arg Met Ala Val Ile His His Leu Asp Leu Arg Gln Gly Arg 
        355                 360                 365             


Gln Gln Asp Leu Ser Gln Phe Pro Leu Glu Lys Ala Arg Leu Gln Val 
    370                 375                 380                 


Gly Met Pro Ile Val Gly Val Gly Ala Leu Ser Val Leu Val Tyr Gly 
385                 390                 395                 400 


Trp Thr Met Gln Phe Arg Thr Pro Leu Val Val Pro Leu Val Ala Leu 
                405                 410                 415     


Phe Val Val Gly Trp Thr Val Ser Ser Ser Thr Asn Ser Ile Ser Val 
            420                 425                 430         


Leu Ile Thr Asp Leu His Leu Asp Thr Gln Ala Thr Ala Thr Ala Ala 
        435                 440                 445             


Asn Asn Leu Val Arg Cys Trp Met Gly Ala Leu Ala Val Ala Val Met 
    450                 455                 460                 


Gly Trp Ala Val Glu Ala Leu Gly Ile Gly Trp Met Gly Thr Val Ile 
465                 470                 475                 480 


Cys Ala Val Tyr Ile Gly Leu Leu Pro Met Leu Met Leu Val Trp Tyr 
                485                 490                 495     


Lys Gly Pro Arg Trp Arg Arg Glu Lys Arg Glu Lys Trp Pro Met Met 
            500                 505                 510         


Thr 
    


<210>  132
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 128

<400>  132

Met Pro Ser Ala Ser Glu Thr Thr Pro Leu Leu Gly Glu Asp Gln Cys 
1               5                   10                  15      


Pro Lys Glu Ser Gln Gly Ala Ile Arg Pro Asp Phe Thr Pro Pro Gln 
            20                  25                  30          


Thr Glu Leu Thr Ala Ser Ser Ile Leu Thr Arg Pro Gln Lys Trp Phe 
        35                  40                  45              


Ile Val Ile Ile Ala Ser Leu Ala Ala Phe Phe Ser Pro Val Ser Ser 
    50                  55                  60                  


Ala Ile Tyr Phe Pro Ala Leu Gly Asp Leu Ala Asp Ala Leu Gly Val 
65                  70                  75                  80  


Ser Thr Phe Leu Ile Asn Leu Thr Val Thr Thr Tyr Leu Val Met Gly 
                85                  90                  95      


Gly Leu Ala Pro Ser Phe Ile Gly Arg Trp Ser Asp Arg Ala Gly Arg 
            100                 105                 110         


Arg Pro Leu Tyr Ile Ala Cys Phe Val Ile Tyr Ile Gly Ser Asn Ile 
        115                 120                 125             


Gly Leu Ala Leu Gln Thr Asn Tyr Val Ala Leu Leu Ile Leu Arg Met 
    130                 135                 140                 


Val Gln Ser Ala Gly Ser Ser Pro Leu Val Ser Leu Ala Gln Ala Val 
145                 150                 155                 160 


Val Ala Asp Met Ala Thr Ser Ala Glu Arg Gly Ala Tyr Ile Ser Tyr 
                165                 170                 175     


Val Ser Ser Gly Ser Ile Leu Gly Pro Ala Val Gly Pro Leu Ile Gly 
            180                 185                 190         


Gly Met Leu Ile Gln Thr Phe Gly Trp Arg Ser Val Phe Trp Phe Leu 
        195                 200                 205             


Ala Ile Phe Ala Gly Val Val Phe Leu Leu Met Leu Ala Cys Leu Pro 
    210                 215                 220                 


Glu Ser Cys Tyr Ala Ser Leu Val Asp Gly Ser Ile Pro Lys Pro Thr 
225                 230                 235                 240 


Leu Ile His Met Ser Trp Leu Ala Tyr Gln Asp Lys Ser Gln Ile Pro 
                245                 250                 255     


Ala Asn Gly Pro Pro Met Thr Ile Ser Thr Ser Pro Thr Ala Ile Glu 
            260                 265                 270         


Leu Asp Arg Lys Ala Pro Pro Thr Gly Ser Leu Arg Val Ile Ala Asp 
        275                 280                 285             


Arg Glu Thr Ser Leu Ile Leu Ile Tyr Ala Gly Cys Asp Leu Ala Gly 
    290                 295                 300                 


Tyr Val Met Val Ser Ala Asn Leu Ser Glu Ala Leu Ser Ala Gln Tyr 
305                 310                 315                 320 


Ala Phe Asn Pro Phe Gln Val Gly Leu Cys Phe Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Asn Phe Leu Ala Thr Leu Thr Thr Gly His Ile Val Asp Trp Asn 
            340                 345                 350         


Phe Arg Arg Tyr Ala Arg Ile His His Asn Asp Leu Arg Gln Gly Arg 
        355                 360                 365             


Gln Gln Asp Leu Ser Gln Phe Pro Ile Glu Lys Ala Arg Leu Gln Val 
    370                 375                 380                 


Gly Met Pro Ile Val Gly Val Gly Ala Leu Ser Val Leu Val Tyr Gly 
385                 390                 395                 400 


Trp Thr Leu Gln Thr Arg Thr Pro Met Ala Val Pro Leu Val Ala Leu 
                405                 410                 415     


Phe Val Val Gly Trp Thr Thr Ser Ser Ser Trp Asn Ser Leu Ser Val 
            420                 425                 430         


Leu Ile Val Asp Leu His Leu Asp Thr Pro Ala Phe Ala Thr Ala Ala 
        435                 440                 445             


Leu Asn Leu Val Arg Ala Trp Met Gly Ala Leu Ala Val Ala Val Met 
    450                 455                 460                 


Gly Pro Ala Val Glu Ala Ile Gly Ile Gly Trp Met Gly Thr Val Ile 
465                 470                 475                 480 


Cys Ala Val Tyr Ile Gly Leu Leu Pro Met Leu Met Leu Val Val Arg 
                485                 490                 495     


Lys Ser Pro Thr Trp Arg Arg Glu Lys Arg Glu Lys Trp Pro Met Met 
            500                 505                 510         


Thr 
    


<210>  133
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 128

<400>  133

Met Pro Ser Leu Ile Glu Thr Ala Pro Leu Leu Gly Gln Leu Gln Cys 
1               5                   10                  15      


Pro Gly Ser Glu Gln Ala Ala Ile Val Leu Asp Phe Glu Pro Pro Gln 
            20                  25                  30          


Asp Glu Leu Asn Ala Ala Ser Ile Thr Thr Glu Pro Gln Lys Ile Leu 
        35                  40                  45              


Ile Val Ile Ile Ala Ser Leu Ala Ala Phe Phe Leu Pro Val Ser Ser 
    50                  55                  60                  


Ala Ile Tyr Phe Pro Ala Leu Gly Ser Leu Ala Asp Ala Leu Gly Val 
65                  70                  75                  80  


Ser Val Ser Thr Ile Asn Leu Thr Val Thr Thr Tyr Leu Val Met Gln 
                85                  90                  95      


Gly Leu Ala Pro Ser Phe Ile Gly Ser Trp Ser Asp Arg Ala Gly Arg 
            100                 105                 110         


Arg Pro Leu Tyr Ile Ala Cys Phe Val Ile Tyr Ile Gly Ser Asn Ile 
        115                 120                 125             


Gly Leu Ala Leu Gln Thr Asn Tyr Val Ala Leu Leu Ile Leu Arg Met 
    130                 135                 140                 


Val Gln Ser Ala Gly Tyr Ser Pro Leu Val Ser Leu Ala Ala Ala Val 
145                 150                 155                 160 


Val Ala Asp Met Ala Thr Ser Ala Glu Arg Gly Arg Tyr Ile Ser Tyr 
                165                 170                 175     


Val Thr Ser Gly Ala Ile Leu Gly Pro Ala Val Gly Pro Leu Ile Gly 
            180                 185                 190         


Gly Met Leu Ile Gln Ser Phe Gly Trp Arg Ser Val Phe Trp Phe Leu 
        195                 200                 205             


Ala Ile Phe Ala Gly Val Val Phe Leu Leu Met Leu Ala Cys Leu Pro 
    210                 215                 220                 


Glu Thr Cys Lys Ala Val Tyr Arg Asp Gly Ser Ile Pro Lys Pro Thr 
225                 230                 235                 240 


Trp Ile His Ala Ser Trp Ala Ala Tyr Arg Ala Arg Ser Ser Gly Pro 
                245                 250                 255     


Leu Asn Gly Pro Pro Ser Thr Ile Ser Thr Ser Pro Ala Ala Glu Arg 
            260                 265                 270         


Pro Arg Arg Lys Ala Ser Pro Thr Lys Ser Leu Arg Val Ile Ala Asp 
        275                 280                 285             


Arg Glu Thr Ser Leu Ile Leu Ile Tyr Gln Gly Cys Val Gln Ala Gly 
    290                 295                 300                 


Tyr Gln Met Val Ser Ala Asn Leu Ser Glu Ala Leu Ser Gln Gln Tyr 
305                 310                 315                 320 


Ala Phe Asn Pro Ala Gln Val Gly Leu Cys Phe Leu Pro Phe Gly Ala 
                325                 330                 335     


Gly Ala Phe Leu Ala Thr Leu Thr Thr Gly His Ile Val Asp Trp Asn 
            340                 345                 350         


Phe Arg Arg Leu Gln Arg Ile His His Leu Asp Leu Arg Gln Gly Arg 
        355                 360                 365             


Gln Gln Asp Leu Ser Gln Phe Pro Thr Glu Lys Ala Arg Leu Pro Val 
    370                 375                 380                 


Gly Met Pro Ile Val Gly Val Ser Ala Leu Ser Val Leu Val Tyr Gly 
385                 390                 395                 400 


Trp Thr Met Gln Ala Arg Ala Pro Leu Val Val Pro Leu Val Ala Leu 
                405                 410                 415     


Phe Val Val Gly Trp Thr Val Ser Ser Ser Thr Asn Ser Ile Ala Val 
            420                 425                 430         


Leu Ile Val Asp Leu His Leu Asp Thr Arg Ala Thr Ala Thr Ala Ala 
        435                 440                 445             


Asn Leu Leu Val Arg Arg Trp Met Gly Ala Leu Ala Val Ala Val Met 
    450                 455                 460                 


Gly Pro Ala Val Glu Ala Ile Gly Ile Gly Pro Met Gly Thr Val Ile 
465                 470                 475                 480 


Cys Ala Val Tyr Ile Gly Leu Leu Pro Met Leu Met Leu Val Trp Arg 
                485                 490                 495     


Lys Gly Pro Thr Trp Arg Arg Lys His Arg Ala Lys Trp Pro Met Met 
            500                 505                 510         


Thr 
    


<210>  134
<211>  1721
<212>  DNA
<213>  Talaromyces stipitatus

<400>  134
atgccggaac cgttcaactc caccatgcct ctcccttctc ctcctaacgc acaacccaaa       60

gatgaaaagg ttgggcttca agactccaac caaccaccgg aaatgtcagc gtcctcagag      120

aagaaacatc ctgaaaatga aaaccggcaa tcgcagcaga atttgcgtcc aaccgagtca      180

gaaaacaatg agccgtactc tgttcatagc tccagcgcca aaaaactaat ggtcttagct      240

gcgtcacttg ctgggttttt ctcgcctttg tcggccagta tatactatcc tgcattgccg      300

gcgattgaga aggccttgaa tgtatccagt acacaggtca atttgacagt caccacgtat      360

ttggtatgtt cgttgctcgg aaagtgtccc agcccattca atttcctgac ctgatacaga      420

ttctacaagg cttagcaccg atggtaactg ccagtttcag cgacagtgct ggacgtcggc      480

ctggttacgc aatatgtttt atagtctacc tcgctgcgaa tctgggcctc gcgttgcaaa      540

atagctatgc cgcattaatg gtattacgag cactacaatc agctgggagt agcggagcca      600

tagccatcgc gaacggtgtc gtcagtgaca ttatcacacc gcaagaacgt ggtagttata      660

ttgcgtttgc ctccgttgga tccatcctgg gaccttccct atcacccatc attggaggtc      720

tgtttgccga gtatacggat tggcattgga ttttctggtt cctgttgatc tttagcggtg      780

cattctgtgt tcccttcttt ctcttcttcc cggaaacttg tcgtaagatt gtgggtaatg      840

ggaaaggggt accgccattc tggaatcgca atctaccaga tatattgcgc gcacgaaagg      900

agaagcaaag gcaacaacgc gccgagaatg aagaagaaaa tgctaatcgg caacgttccc      960

gtctatccat tccaaacccc ttgaaagtct tcgtcgtttt caccaacctt caaaccgtca     1020

tgacgctctg ccctgccggt gtggcattcg gaagctacta tgctgttttg acaggcgcct     1080

cgggtgaatt cacaagggtt taccacttca gcgagatcaa agtagctctc atatttctac     1140

ccatgggtgt cggcggattg atttcagctt tatctacagg taaactggtg aattggaatt     1200

tccaccgtca cgcgcgcaaa cgtggtatca tggttgctcg aaaccggaga caggaactac     1260

tcaatttccc catcgagcga gccaggctag agattgccct tccagtgttt tgtcttgggt     1320

gcgtctgcac tgtgctctat ggctggttga tgactcaaga tgtgaacgta tctggcccaa     1380

tcattctact cttcgttatg agttggtcct ttgccgcatt ttaccaagtt ctcaacgtct     1440

tattagtcga cacctatccc ggccgaggag cgatggtgac tgcagtcgta aacctgctta     1500

gatgtgagat tggtgctggt atggcggcaa tgatcagtcc gttgaccagc gctactggtt     1560

ctgggtggtc gtatacgatt attgccttga ttggggttgc tgccactagt ccgttgctgc     1620

taacgatgaa gtatgggatg aaatggagac aagagagtgc agcaaaagca gaagagaaga     1680

agagtagaat gcaggaggcg cagcaaagac aggaggttta g                         1721


<210>  135
<211>  554
<212>  PRT
<213>  Talaromyces stipitatus

<400>  135

Met Pro Glu Pro Phe Asn Ser Thr Met Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Lys Asp Glu Lys Val Gly Leu Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Glu Lys Lys His Pro Glu Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Arg Pro Thr Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Val His Ser Ser Ser Ala Lys Lys Leu Met Val Leu Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Ser Pro Leu Ser Ala Ser Ile Tyr Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Ser Thr Gln 
            100                 105                 110         


Val Asn Leu Thr Val Thr Thr Tyr Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Tyr Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Ile Ala Asn Gly Val Val Ser Asp Ile 
            180                 185                 190         


Ile Thr Pro Gln Glu Arg Gly Ser Tyr Ile Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Leu Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Ile Val Gly Asn Gly Lys Gly Val Pro Pro Phe Trp Asn Arg Asn 
            260                 265                 270         


Leu Pro Asp Ile Leu Arg Ala Arg Lys Glu Lys Gln Arg Gln Gln Arg 
        275                 280                 285             


Ala Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Leu Ser 
    290                 295                 300                 


Ile Pro Asn Pro Leu Lys Val Phe Val Val Phe Thr Asn Leu Gln Thr 
305                 310                 315                 320 


Val Met Thr Leu Cys Pro Ala Gly Val Ala Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Leu Thr Gly Ala Ser Gly Glu Phe Thr Arg Val Tyr His Phe Ser 
            340                 345                 350         


Glu Ile Lys Val Ala Leu Ile Phe Leu Pro Met Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Ile Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Leu Gly Cys Val Cys Thr Val Leu Tyr Gly Trp Leu Met 
            420                 425                 430         


Thr Gln Asp Val Asn Val Ser Gly Pro Ile Ile Leu Leu Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Ala Ala Phe Tyr Gln Val Leu Asn Val Leu Leu Val 
    450                 455                 460                 


Asp Thr Tyr Pro Gly Arg Gly Ala Met Val Thr Ala Val Val Asn Leu 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Gly Trp Ser Tyr Thr Ile Ile Ala Leu Ile 
            500                 505                 510         


Gly Val Ala Ala Thr Ser Pro Leu Leu Leu Thr Met Lys Tyr Gly Met 
        515                 520                 525             


Lys Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Glu Lys Lys Ser Arg 
    530                 535                 540                 


Met Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  136
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  136

Met Pro Glu Pro Phe Asn Ser Thr Met Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Gly Gln Pro Lys Asp Glu Lys Val Gly Leu Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Glu Lys Lys His Pro Glu Gln Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Arg Pro Thr Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Val His Ser Ser Ser Ala Lys Lys Leu Leu Val Leu Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Ser Pro Leu Ser Ala Ser Ile Tyr Trp 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Ser Thr Gln 
            100                 105                 110         


Val Asn Leu Thr Val Thr Thr Tyr Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Trp Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Gly Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Ile Ala Asn Gly Val Val Ser Asp Ile 
            180                 185                 190         


Ile Ser Pro Gln Glu Arg Gly Ser Tyr Ile Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Leu Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Leu Val Gly Asn Ala Lys Gly Ile Pro Pro Phe Trp Asn Arg Asn 
            260                 265                 270         


Leu Pro Asp Ile Leu Arg Ala Arg Lys Glu Lys Gln Arg Asn Gln Arg 
        275                 280                 285             


Ala Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Val Ser 
    290                 295                 300                 


Ile Pro Asn Pro Leu Lys Val Phe Val Val Phe Thr Asn Leu Gln Thr 
305                 310                 315                 320 


Val Ile Thr Leu Cys Pro Ala Gly Val Gly Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Leu Thr Gly Ala Ser Gly Glu Phe Thr Arg Met Tyr His Phe Ser 
            340                 345                 350         


Glu Leu Lys Val Ala Leu Ile Phe Leu Pro Ile Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Arg Arg Gly Leu Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Ile Gly Cys Val Cys Thr Val Leu Tyr Gly Trp Leu Met 
            420                 425                 430         


Ser Gln Asp Val Asn Ile Ser Gly Pro Ile Ile Leu Ile Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Ala Ala Phe Tyr Gln Val Leu Asn Val Leu Leu Val 
    450                 455                 460                 


Asp Thr Tyr Pro Gly Arg Gly Ala Met Val Thr Ala Val Val Asn Leu 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Gly Trp Ser Tyr Thr Ile Val Ala Leu Leu 
            500                 505                 510         


Ala Val Ala Ala Thr Ser Pro Leu Leu Val Thr Met Lys Tyr Gly Met 
        515                 520                 525             


Lys Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Glu Lys Lys Ser Arg 
    530                 535                 540                 


Val Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  137
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  137

Met Pro Glu Pro Phe Asn Ser Ser Met Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Lys Asp Glu Lys Val Gly Leu Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Glu Lys Lys His Pro Asp Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Arg Pro Thr Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Val His Ser Ser Ser Ala Lys Lys Leu Met Val Leu Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Ser Pro Leu Ser Ala Ser Ile Phe Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Thr Thr Gln 
            100                 105                 110         


Leu Asn Leu Thr Val Thr Thr Tyr Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Trp Leu Ala Ala Asn Leu Gly Met Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Ile Ala Asn Ala Val Val Thr Asp Val 
            180                 185                 190         


Ile Ser Pro Gln Glu Arg Gly Ser Tyr Ile Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Leu Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Ile Ile Gly Asn Gly Lys Gly Val Pro Pro Phe Trp Asn Arg Asn 
            260                 265                 270         


Leu Pro Asp Ile Leu Arg Gly Arg Arg Glu Arg Gln Arg Gln Gln Arg 
        275                 280                 285             


Ala Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Ile Ser 
    290                 295                 300                 


Ile Pro Asn Pro Leu Arg Val Phe Val Val Phe Thr Asn Leu Gln Thr 
305                 310                 315                 320 


Val Met Thr Val Cys Pro Ala Gly Val Ala Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Leu Ser Ala Ala Ser Gly Glu Phe Thr Arg Val Tyr His Phe Ser 
            340                 345                 350         


Glu Ile Lys Val Ala Leu Ile Phe Leu Pro Met Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Val Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Leu Gly Cys Val Cys Thr Val Leu Tyr Gly Trp Leu Met 
            420                 425                 430         


Thr Gln Asp Val Asn Val Ser Gly Pro Ile Ile Met Leu Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Ala Ala Phe Tyr Gln Val Leu Gln Val Leu Leu Val 
    450                 455                 460                 


Asp Thr Tyr Pro Gly Arg Ala Ala Met Val Thr Ala Val Ile Asn Leu 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Gly Trp Ser Tyr Thr Ile Ile Ala Leu Ile 
            500                 505                 510         


Gly Val Ala Ala Thr Ser Pro Leu Leu Leu Thr Met Lys Tyr Gly Ile 
        515                 520                 525             


Arg Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Glu Lys Lys Ser Arg 
    530                 535                 540                 


Val Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  138
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  138

Met Pro Glu Pro Phe Asn Ser Thr Met Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Lys Asp Glu Lys Val Gly Leu Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Glu Lys Lys His Pro Glu Asn Asp Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Val Lys Pro Thr Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Val His Ser Ser Ser Ala Lys Lys Leu Met Val Val Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Ser Pro Leu Ser Ala Thr Val Tyr Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Ser Thr Gln 
            100                 105                 110         


Val Asn Leu Thr Met Thr Thr Tyr Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Ala Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Tyr Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Ile Ala Asn Ala Val Val Ser Asp Ile 
            180                 185                 190         


Ile Thr Pro Gln Glu Arg Gly Ser Tyr Ile Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Leu Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Thr 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Ile Val Gly Asn Gly Lys Gly Val Pro Pro Phe Trp Asn Arg Asn 
            260                 265                 270         


Val Pro Asp Ile Leu Arg Ala Arg Lys Glu Arg Gln Arg Gln Gln Arg 
        275                 280                 285             


Gly Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Leu Thr 
    290                 295                 300                 


Leu Pro Gln Pro Leu Lys Leu Phe Val Val Phe Thr Asn Leu Gln Thr 
305                 310                 315                 320 


Val Met Thr Leu Cys Pro Ala Gly Val Ala Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Leu Thr Gly Ala Ser Gly Glu Phe Thr Arg Val Tyr His Phe Ser 
            340                 345                 350         


Glu Ile Lys Val Ala Leu Leu Phe Leu Pro Met Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Met Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Leu Gly Cys Val Cys Thr Val Leu Tyr Gly Trp Leu Met 
            420                 425                 430         


Thr Gln Asp Val Asn Val Ser Gly Pro Leu Ile Val Val Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Gly Ala Tyr Phe Gln Val Leu Asn Val Met Leu Val 
    450                 455                 460                 


Asp Thr Tyr Pro Gly Arg Gly Ala Ile Val Thr Ala Val Ile Asn Leu 
465                 470                 475                 480 


Ile Arg Cys Glu Ile Gly Ala Gly Met Ala Gly Met Met Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Gly Trp Ser Phe Thr Ile Leu Ala Leu Ile 
            500                 505                 510         


Gly Val Ala Ala Thr Ser Pro Leu Leu Leu Thr Ile Lys Tyr Gly Met 
        515                 520                 525             


Lys Trp Lys Asn Glu Ser Ala Ala Arg Ala Glu Asp Lys Arg Ser Arg 
    530                 535                 540                 


Met Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  139
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  139

Met Pro Glu Pro Phe Asn Ser Thr Met Pro Leu Pro Thr Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Lys Asp Glu Arg Leu Gly Ile Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Val Ser Ala Ser Ser Glu Lys Lys His Pro Glu Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Arg Pro Thr Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Ile His Ser Ser Ser Ala Arg Lys Leu Met Val Leu Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Ser Pro Leu Ser Ala Ser Ile Tyr Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Met Ser Ser Thr Gln 
            100                 105                 110         


Val Asn Leu Thr Val Thr Thr Tyr Leu Ile Leu Asn Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Tyr Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Asn Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Ile Ala Gln Ala Val Val Ser Asp Leu 
            180                 185                 190         


Ile Thr Pro Gln Glu Arg Gly Ser Tyr Ile Ala Phe Gly Ser Val Gly 
        195                 200                 205             


Ser Met Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Val Phe Ala 
    210                 215                 220                 


Glu Trp Thr Asp Trp His Trp Met Phe Phe Phe Leu Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Trp Trp Leu Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Ile Val Gly Asn Gly Lys Gly Val Pro Pro Phe Trp Asn Arg Asn 
            260                 265                 270         


Leu Pro Asp Ile Val Arg Ala Arg Lys Glu Lys Gln Arg Gln Gln Arg 
        275                 280                 285             


Ala Glu Asn Asp Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Leu Thr 
    290                 295                 300                 


Ile Pro Asn Pro Leu Lys Leu Trp Val Val Phe Thr Asn Leu Gln Thr 
305                 310                 315                 320 


Val Met Thr Leu Cys Pro Ala Gly Val Ala Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Leu Thr Gly Ala Ser Gly Glu Phe Ser Arg Val Trp His Phe Ser 
            340                 345                 350         


Glu Val Lys Val Ala Leu Ile Phe Leu Pro Met Ala Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Gly Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Ile Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Leu Gly Cys Val Cys Ser Val Leu Tyr Gly Phe Leu Met 
            420                 425                 430         


Thr Gln Asp Val Asn Val Ser Gly Pro Ile Ile Leu Leu Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Ala Ala Phe Tyr Gln Val Leu Asn Val Ile Leu Val 
    450                 455                 460                 


Glu Thr Tyr Pro Gly Arg Gly Ala Leu Val Thr Ala Val Val Asn Leu 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Gly Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Ser Ser Ala Thr Gly Ser Gly Trp Ser Tyr Thr Ile Ile Ala Leu Ile 
            500                 505                 510         


Gly Val Ala Ala Thr Ser Pro Leu Leu Leu Thr Met Lys Tyr Gly Met 
        515                 520                 525             


Lys Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Asp Lys Lys Ser Arg 
    530                 535                 540                 


Met Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  140
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  140

Met Pro Glu Pro Phe Asn Ser Thr Leu Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Gly Gln Pro Lys Asp Asp Lys Val Gly Leu Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Asp Lys Lys His Pro Glu Asn Asp Asn 
        35                  40                  45              


Lys Gln Ser Gln Gln Asn Leu Arg Pro Ser Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Val His Ser Ser Ser Ala Lys Lys Leu Met Val Ile Ala 
65                  70                  75                  80  


Ala Ser Leu Gly Gly Phe Phe Ser Pro Leu Ser Ala Ser Ile Tyr Phe 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Thr Thr Gln 
            100                 105                 110         


Val Asn Leu Thr Val Thr Thr Trp Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Phe Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Ile Ala Asn Ala Val Val Ser Asp Ile 
            180                 185                 190         


Ile Thr Pro Gln Asp Arg Gly Ser Tyr Ile Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Ile Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Phe Phe Pro Glu Ser Cys Arg 
                245                 250                 255     


Arg Ile Val Gly Asn Gly Lys Ala Val Pro Pro Phe Phe Asn Lys Asn 
            260                 265                 270         


Ile Pro Asp Ile Leu Arg Ala Lys Lys Glu Lys Gln Arg Gln Gln Arg 
        275                 280                 285             


Ala Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Ile Ser 
    290                 295                 300                 


Leu Pro Asn Pro Leu Lys Val Phe Val Met Phe Ser Asn Leu Gln Thr 
305                 310                 315                 320 


Leu Met Thr Leu Cys Pro Ala Gly Leu Ala Tyr Gly Ser Tyr Tyr Gly 
                325                 330                 335     


Val Leu Thr Gly Ala Ser Gly Glu Phe Thr Arg Val Phe His Phe Ser 
            340                 345                 350         


Glu Ile Lys Val Ala Val Leu Phe Leu Pro Met Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Ile Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Leu Ala Cys Val Cys Thr Val Leu Tyr Gly Trp Met Leu 
            420                 425                 430         


Thr Gln Asp Val Asn Val Ser Gly Pro Val Ile Leu Ile Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Gly Gly Phe Tyr Gln Leu Val Asn Val Leu Leu Ile 
    450                 455                 460                 


Asp Thr Phe Pro Ala Arg Gly Ala Met Val Thr Ala Val Ile Asn Leu 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Ser Ser Gly Thr Gly Ser Gly Trp Thr Tyr Thr Ile Leu Ala Leu Leu 
            500                 505                 510         


Ala Val Ala Ala Ser Ser Pro Leu Leu Val Thr Met Lys Tyr Gly Met 
        515                 520                 525             


Lys Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Glu Arg Lys Ser Arg 
    530                 535                 540                 


Met Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  141
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  141

Met Pro Glu Pro Phe Asn Ser Ser Leu Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Lys Asp Asp Lys Val Gly Val Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Glu Lys Lys His Pro Glu Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Arg Pro Thr Glu Thr Glu Asn Asn Glu 
    50                  55                  60                  


Pro Phe Ser Val His Ser Ser Ser Ala Lys Lys Leu Val Val Ile Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Ser Pro Leu Ser Ala Ser Ile Tyr Tyr 
                85                  90                  95      


Pro Ala Ile Pro Ala Ile Glu Arg Ala Leu Asn Leu Ser Ser Ser Gln 
            100                 105                 110         


Val Asn Leu Thr Val Thr Thr Tyr Val Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Tyr Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Val Ala Asn Gly Val Val Ser Asp Leu 
            180                 185                 190         


Leu Thr Pro Gln Glu Arg Gly Ser Tyr Met Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Val Phe Gly 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Ile Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Ile Val Gly Asn Gly Lys Gly Val Pro Pro Phe Tyr Asn Arg Asn 
            260                 265                 270         


Ile Pro Asp Val Leu Arg Ala Arg Lys Asp Arg Gln Arg Gln Gln Arg 
        275                 280                 285             


Ala Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Arg Ser Arg Leu Ser 
    290                 295                 300                 


Ile Pro Asn Pro Leu Lys Val Phe Val Val Phe Ser Asn Leu Gln Thr 
305                 310                 315                 320 


Leu Val Thr Met Cys Pro Ala Gly Val Ala Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Met Thr Gly Ala Ser Gly Glu Phe Thr Arg Val Tyr His Phe Ser 
            340                 345                 350         


Asp Ile Lys Val Ala Leu Leu Tyr Leu Pro Leu Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Gly Leu Ser Thr Gly Lys Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Ile Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Leu Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Ile Gly Cys Val Cys Thr Val Leu Tyr Ala Trp Leu Met 
            420                 425                 430         


Thr Gln Asp Val Asn Val Ser Ala Pro Val Ile Leu Ile Phe Val Met 
        435                 440                 445             


Ser Trp Ser Phe Ala Ala Tyr Trp Gln Val Leu Asn Val Leu Leu Val 
    450                 455                 460                 


Asp Thr Phe Pro Gly Arg Gly Ala Met Val Ser Ala Val Ile Asn Leu 
465                 470                 475                 480 


Ile Arg Cys Glu Ile Gly Gly Gly Met Ala Ala Met Val Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Gly Trp Ser Phe Thr Ile Leu Ala Leu Leu 
            500                 505                 510         


Gly Val Ala Gly Thr Ser Pro Leu Leu Leu Thr Met Lys Tyr Gly Ile 
        515                 520                 525             


Lys Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Glu Lys Lys Ser Arg 
    530                 535                 540                 


Ile Asn Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  142
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  142

Met Pro Glu Pro Phe Asn Thr Thr Leu Pro Met Pro Thr Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Arg Asp Glu Lys Val Gly Val Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Asp Met Ser Ala Ser Ser Asp Lys Lys His Pro Asp Asn Glu Asn 
        35                  40                  45              


Lys Asn Thr Gln Asn Gln Leu Arg Pro Ser Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Thr Val His Thr Ser Ser Ala Lys Lys Ile Ile Val Ile Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Ala Phe Phe Ser Pro Leu Ser Ala Ser Ile Phe Tyr 
                85                  90                  95      


Pro Gly Leu Pro Ala Ile Asp Lys Ala Leu Asn Leu Ser Ser Thr Gln 
            100                 105                 110         


Leu Asn Leu Thr Leu Thr Thr Phe Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Trp Ile Val Phe Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Tyr Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Leu Ala Ile Ala Asn Gly Val Val Ser Asp Ile 
            180                 185                 190         


Val Ser Pro Gln Glu Arg Gly Ser Tyr Leu Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Met Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Ile Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Tyr Phe Pro Glu Thr Cys Lys 
                245                 250                 255     


Lys Ile Val Gly Asn Ala Arg Gly Val Pro Pro Phe Trp Gln Arg Gln 
            260                 265                 270         


Leu Pro Asp Ile Leu Arg Ala Lys Lys Glu Lys Gln Arg Gln Gln Arg 
        275                 280                 285             


Ala Glu Asn Asp Asp Glu Asn Ala Asn Arg Asn Arg Ser Arg Leu Thr 
    290                 295                 300                 


Ile Pro Asn Pro Ile Lys Val Phe Leu Val Phe Thr Asn Leu Gln Thr 
305                 310                 315                 320 


Val Met Thr Ile Cys Pro Ala Gly Val Ala Phe Gly Ser Phe Tyr Gly 
                325                 330                 335     


Val Ile Ser Gly Ala Ser Ala Glu Phe Thr Lys Leu Tyr His Phe Ser 
            340                 345                 350         


Glu Ile Lys Met Ala Leu Met Phe Leu Pro Met Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Ser Gly Arg Leu Val Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Ile Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Leu Gly Leu Pro 
                405                 410                 415     


Leu Phe Cys Leu Ala Cys Val Cys Thr Val Leu Phe Gly Trp Leu Met 
            420                 425                 430         


Ser Gln Asp Val Asn Val Ser Gly Pro Val Ile Leu Leu Phe Val Leu 
        435                 440                 445             


Ser Trp Ser Phe Ala Ala Tyr Tyr Gln Val Leu Asn Val Val Ile Val 
    450                 455                 460                 


Asp Ser Phe Pro Gly Arg Gly Ala Met Val Thr Ala Val Leu Asn Leu 
465                 470                 475                 480 


Ile Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Gly Trp Ser Phe Thr Leu Ile Ala Leu Ile 
            500                 505                 510         


Gly Val Ala Gly Thr Ser Pro Leu Leu Leu Thr Met Lys Tyr Gly Met 
        515                 520                 525             


Arg Trp Arg Gln Asp Ser Ala Ala Lys Ala Glu Glu Arg Lys Ser Arg 
    530                 535                 540                 


Met Gln Glu Ala Asn Gln Arg Gln Asp Val 
545                 550                 


<210>  143
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  143

Met Pro Glu Pro Phe Asn Ser Thr Met Pro Val Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Asn Pro Lys Asp Asp Lys Val Gly Leu Gln Glu Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Val Thr Ala Ser Ser Glu Lys Arg His Pro Glu Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Arg Pro Thr Glu Ser Asp Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Ile His Ser Ser Thr Ala Arg Lys Leu Ile Val Leu Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Ala Phe Phe Ser Pro Leu Ser Ala Ser Met Tyr Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Leu Ser Ser Ser Gln 
            100                 105                 110         


Val Asn Leu Thr Val Thr Thr Phe Val Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Trp Leu Ala Ala Asn Leu Gly Leu Ala Leu 
145                 150                 155                 160 


Gln Asn Ser Trp Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Val Ala Asn Gly Val Val Ser Asp Leu 
            180                 185                 190         


Val Thr Pro Gln Glu Arg Gly Ser Tyr Leu Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Ser Met Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Ala Ile Phe Gly 
    210                 215                 220                 


Asp Tyr Thr Asp Trp His Trp Ile Phe Trp Phe Leu Leu Ile Phe Thr 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Trp Leu Phe Phe Pro Glu Thr Cys Arg 
                245                 250                 255     


Lys Leu Val Gly Asn Ala Lys Ala Val Pro Pro Phe Trp Asn Arg Asn 
            260                 265                 270         


Ile Pro Asp Leu Leu Arg Gly Arg Lys Glu Lys Gln Arg Gln Gln Lys 
        275                 280                 285             


Ala Glu Asn Asp Glu Glu Asn Ala Gln Arg Gln Arg Ser Arg Ile Ser 
    290                 295                 300                 


Ile Pro Asn Pro Ile Lys Leu Phe Val Val Phe Ser Asn Leu Gln Thr 
305                 310                 315                 320 


Val Met Thr Leu Cys Pro Ala Gly Val Gly Phe Gly Ser Tyr Tyr Ala 
                325                 330                 335     


Val Val Ser Gly Ala Ser Gly Glu Phe Thr Arg Val Tyr His Phe Ser 
            340                 345                 350         


Glu Ile Lys Leu Ala Leu Ile Phe Leu Pro Leu Gly Val Gly Gly Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Lys Leu Ile Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Arg Gly Leu Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Ile Ala Leu Pro 
                405                 410                 415     


Val Phe Cys Val Gly Cys Val Cys Ser Val Leu Phe Gly Phe Met Leu 
            420                 425                 430         


Ser Gln Asp Ile Asn Val Thr Gly Pro Val Ile Leu Ile Phe Val Val 
        435                 440                 445             


Ser Trp Ser Phe Gly Ala Phe Tyr Gln Ile Val Asn Val Ile Leu Met 
    450                 455                 460                 


Asp Thr Tyr Pro Gly Arg Gly Ala Met Val Thr Ala Val Met Gln Leu 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Ser Ala Trp Ser Phe Thr Met Val Ala Leu Val 
            500                 505                 510         


Ala Val Ala Ala Thr Ser Pro Leu Leu Met Ser Ile Lys Trp Gly Leu 
        515                 520                 525             


Arg Trp Arg Gln Glu Ser Ala Ala Lys Ala Glu Glu Lys Arg Ser Arg 
    530                 535                 540                 


Leu Gln Glu Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  144
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  144

Met Pro Glu Pro Phe Asn Ser Thr Met Pro Leu Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Gln Pro Lys Glu Asp Arg Val Gly Ile Gln Asp Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Met Ser Ala Ser Ser Glu Arg Lys His Pro Glu Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Leu Lys Pro Ser Glu Ser Glu Asn Asn Glu 
    50                  55                  60                  


Pro Tyr Ser Val His Ser Ser Ser Ala Lys Lys Leu Leu Val Leu Ala 
65                  70                  75                  80  


Ala Thr Leu Gly Gly Phe Phe Ser Pro Leu Ser Ala Thr Val Tyr Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Thr Thr Gln 
            100                 105                 110         


Leu Asn Leu Thr Val Thr Thr Tyr Ile Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Ser Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Gly Ile Cys Trp Ile Val Trp Leu Ala Ala Asn Leu Gly Ile Ala Ile 
145                 150                 155                 160 


Gln Asn Ser Phe Ala Ala Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Met Gly Asn Ala Val Val Ser Glu Val 
            180                 185                 190         


Ile Ser Pro Gln Asp Arg Gly Ser Phe Leu Ala Phe Ala Ser Val Gly 
        195                 200                 205             


Thr Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Leu Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Val Phe Trp Phe Val Leu Ile Phe Ser 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Tyr Leu Tyr Phe Pro Asp Thr Cys Arg 
                245                 250                 255     


Arg Ile Val Gly Asn Ala Arg Ala Val Pro Pro Trp Trp Asn Arg Asn 
            260                 265                 270         


Leu Pro Asp Leu Leu Lys Gly Arg Arg Asp Lys Asn Arg Asn Asn Lys 
        275                 280                 285             


Gly Glu Asn Glu Glu Glu Asn Ala Asn Arg Gln Lys Ser Lys Leu Ser 
    290                 295                 300                 


Met Pro Gln Pro Leu Lys Val Phe Val Leu Phe Thr Asn Leu Asn Thr 
305                 310                 315                 320 


Leu Ile Thr Ile Cys Pro Ala Gly Leu Ala Phe Gly Ser Tyr Trp Ala 
                325                 330                 335     


Ile Leu Ser Gly Ala Ser Ala Glu Phe Ser Arg Met Tyr His Trp Ser 
            340                 345                 350         


Glu Ile Lys Ile Ala Leu Leu Phe Leu Pro Val Ala Val Gly Ala Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Arg Leu Leu Asn Trp Asn Phe His Arg 
    370                 375                 380                 


His Ala Arg Lys Lys Gly Ile Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Met Ala Met Pro 
                405                 410                 415     


Val Phe Cys Leu Ala Cys Val Cys Thr Val Leu Tyr Gly Phe Val Val 
            420                 425                 430         


Ser Gln Asp Val Gln Leu Ser Gly Pro Ile Ile Leu Leu Phe Val Met 
        435                 440                 445             


Ser Trp Ser Trp Ala Ala Tyr Tyr Gln Val Leu Asn Val Met Val Ile 
    450                 455                 460                 


Asp Ser Phe Pro Gly Arg Gly Ala Met Val Thr Ala Val Ile Asn Leu 
465                 470                 475                 480 


Met Arg Cys Glu Ile Ala Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Ser Ala Thr Gly Thr Gly Trp Thr Tyr Thr Val Ile Ala Leu Ile 
            500                 505                 510         


Ala Val Ala Ala Thr Ser Pro Val Val Leu Ser Ile Lys Tyr Gly Leu 
        515                 520                 525             


Arg Trp Lys Gln Glu Ser Ala Gly Lys Ala Asp Glu Lys Lys Ser Arg 
    530                 535                 540                 


Val Gln Asp Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  145
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 135

<400>  145

Met Pro Glu Pro Trp Asn Ser Ser Met Pro Met Pro Ser Pro Pro Asn 
1               5                   10                  15      


Ala Asn Pro Lys Glu Asp Arg Val Gly Leu Gln Glu Ser Asn Gln Pro 
            20                  25                  30          


Pro Glu Leu Thr Ala Ser Ser Asp Arg Lys His Pro Asp Asn Glu Asn 
        35                  40                  45              


Arg Gln Ser Gln Gln Asn Ile Arg Pro Ser Asp Ser Asp Asn Asn Glu 
    50                  55                  60                  


Pro Phe Ser Val His Ser Ser Ser Ala Lys Lys Leu Ile Val Ile Ala 
65                  70                  75                  80  


Ala Ser Leu Ala Gly Phe Phe Thr Pro Leu Ser Ala Ser Val Tyr Tyr 
                85                  90                  95      


Pro Ala Leu Pro Ala Ile Glu Lys Ala Leu Asn Val Ser Thr Thr Gln 
            100                 105                 110         


Ile Asn Leu Thr Val Thr Thr Tyr Leu Ile Leu Gln Gly Leu Ala Pro 
        115                 120                 125             


Met Val Thr Ala Ser Phe Ser Asp Ser Ala Gly Arg Arg Pro Gly Tyr 
    130                 135                 140                 


Ala Ile Cys Phe Ile Val Tyr Leu Ala Ala Asn Leu Gly Val Ala Val 
145                 150                 155                 160 


Gln Gln Ser Tyr Ala Gly Leu Met Val Leu Arg Ala Leu Gln Ser Ala 
                165                 170                 175     


Gly Ser Ser Gly Ala Ile Ala Leu Gly Asn Gly Val Val Ser Glu Ile 
            180                 185                 190         


Ile Thr Pro Gln Glu Arg Gly Thr Tyr Ile Ala Phe Ala Ser Val Ala 
        195                 200                 205             


Ser Ile Leu Gly Pro Ser Leu Ser Pro Ile Ile Gly Gly Ile Phe Ala 
    210                 215                 220                 


Glu Tyr Thr Asp Trp His Trp Leu Phe Trp Phe Met Leu Ile Phe Thr 
225                 230                 235                 240 


Gly Ala Phe Cys Val Pro Phe Phe Leu Phe Phe Pro Asp Ser Cys Lys 
                245                 250                 255     


Lys Ile Val Gly Asn Gly Arg Gly Leu Pro Pro Phe Trp Asn Lys Asn 
            260                 265                 270         


Val Pro Asp Leu Leu Arg Gly Arg Arg Glu Lys Gln Arg Gln Asn Arg 
        275                 280                 285             


Ala Glu Asn Glu Asp Glu Gln Ala Gln Arg Gln Arg Ser Arg Leu Ser 
    290                 295                 300                 


Ile Pro Asn Pro Leu Lys Leu Phe Val Leu Phe Thr Gln Leu Gln Thr 
305                 310                 315                 320 


Ile Leu Thr Met Cys Pro Ala Gly Leu Ala Phe Gly Thr Phe Phe Gly 
                325                 330                 335     


Ile Leu Thr Ala Ala Ser Gly Glu Phe Ser Arg Val Phe His Tyr Ser 
            340                 345                 350         


Glu Val Arg Val Ala Ile Ile Phe Leu Pro Leu Ala Val Gly Ala Leu 
        355                 360                 365             


Ile Ser Ala Leu Ser Thr Gly Arg Leu Leu Asn Trp Asn Phe His Lys 
    370                 375                 380                 


His Ala Lys Lys Arg Gly Leu Met Val Ala Arg Asn Arg Arg Gln Glu 
385                 390                 395                 400 


Leu Leu Asn Phe Pro Ile Glu Arg Ala Arg Leu Glu Leu Ala Val Pro 
                405                 410                 415     


Val Tyr Cys Leu Gly Cys Val Cys Thr Val Leu Phe Gly Tyr Leu Leu 
            420                 425                 430         


Thr Gln Asp Val Asn Ile Ser Ala Pro Ile Ile Val Leu Phe Val Leu 
        435                 440                 445             


Ser Trp Ser Phe Gly Gly Phe Trp Gln Val Leu Asn Leu Ile Val Ile 
    450                 455                 460                 


Asp Ser Tyr Pro Gly Arg Gly Ala Leu Val Thr Ala Val Val Asn Val 
465                 470                 475                 480 


Leu Arg Cys Glu Ile Gly Ala Gly Met Ala Ala Met Ile Ser Pro Leu 
                485                 490                 495     


Thr Thr Ala Thr Gly Ser Gly Phe Ser Phe Thr Leu Ile Ala Leu Val 
            500                 505                 510         


Gly Val Ala Ala Thr Ser Pro Ile Leu Leu Thr Leu Lys Tyr Gly Val 
        515                 520                 525             


Lys Trp Arg Gln Glu Ser Ala Ala Arg Ala Glu Asp Lys Lys Ser Arg 
    530                 535                 540                 


Ile Asn Asp Ala Gln Gln Arg Gln Glu Val 
545                 550                 


<210>  146
<211>  1661
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  146
atgggggatc atttaatatt cttggatcag attgtacagg gctccctcag gctttgccca       60

ggttcaatgc actctgtcat ggcttcatcc accaagatcc ccatcccccg ggtcaccgtc      120

gacgaagcca ctgctcttct tgcaccgccg caaccgcctt actcggtgtt ttccccagtg      180

cagaagaagc tcattgtctt cacggcagcc ttggcctcga ccttttcgcc tctctcatcc      240

aatatctact acccggctat caactccatt gccgatgagt tgaagatcag tcccggaatg      300

gtcaacctaa ccatcacggc ctatatggta agctcgtatg ctttgtcata ctttctcacg      360

gctctcgaga cagttcctga tcaacactac aggtttttca agggctaacc cccgccttta      420

tgggagatct ctcggatacg gccggccgac ggccggtata tgtcctctgc ttcggcatct      480

atatcgtagc caacatcggc ttagctctgc aacgagattt tgtgactctt ctggtgctgc      540

gggccctgca aagtaccggc atcagcgcca ctgtcgcgct atccaacgcc gttgcggccg      600

acaccgtgac gtccgccgag cgggggatgt atttgggcat cgcctctctc gggggaatcc      660

tgggacccgc gctggggcca accctaggcg gtctcttgag tcaatccctc ggatggcggt      720

ctatcttctg gtttctggcg ctcgtggctg ccgtcttttt cgtgcttttg atgctgttct      780

tccccgagac ctgccgtgcg atcgtgggca atgggtccat tccacctcct cggtggaatc      840

gctctctgct cgactgtatg gtcggacgga ctcgagggaa gcaacagcta aatctgtcgc      900

cggaagctga taatgctcct cccaagccac accaaaagtc gcggatccgt gtgcccaacc      960

cctggagcac gctgcgtctg ctctttgaaa tgccaacggg gttggtcctt ctgagcaatg     1020

gaatcggata cgcggcctat tacgccgtca cctcgacggt gccgacgcag tggaacgaga     1080

tttaccatct caacgacttc cagctcggac tcacctatat tcccattggg ttgggcacca     1140

tcctgtcggc cttcaccaac ggatggctcg tcgactggaa cttccaacgc atcgcccgcc     1200

aggtcggaca gctgccgatc cgcaacggga agcaggatct ccggcagttt cccattgagc     1260

gcgcacggct gcagattgcc atgccgtcag cgatgctggc ggccgcctcg attgccctct     1320

acggctgggt gatcgcggcc gaacgcccca tcgtggaggc gctggccatg ctccttctga     1380

tcggatatct cgtcacggcg agctacaatg tcatgaacgt gctgattgta gatctccatt     1440

acggaaagcc ggccacagcg accgccgcaa acaacctggt gcgctgctta ctcggggcgg     1500

gagccacggc gggcgtcacg cccctcctgg atcttctggg ccgacaatgg tgtttctgcg     1560

tggtgggtgc catctacgtg atatctctgc ctctgagcgg gcttgtgtat gggtttggcg     1620

caggatggcg agaaaaaaga gatgccgaga gagatgggta g                         1661


<210>  147
<211>  509
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  147

Met His Ser Val Met Ala Ser Ser Thr Lys Ile Pro Ile Pro Arg Val 
1               5                   10                  15      


Thr Val Asp Glu Ala Thr Ala Leu Leu Ala Pro Pro Gln Pro Pro Tyr 
            20                  25                  30          


Ser Val Phe Ser Pro Val Gln Lys Lys Leu Ile Val Phe Thr Ala Ala 
        35                  40                  45              


Leu Ala Ser Thr Phe Ser Pro Leu Ser Ser Asn Ile Tyr Tyr Pro Ala 
    50                  55                  60                  


Ile Asn Ser Ile Ala Asp Glu Leu Lys Ile Ser Pro Gly Met Val Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Ala Tyr Met Val Phe Gln Gly Leu Thr Pro Ala Phe 
                85                  90                  95      


Met Gly Asp Leu Ser Asp Thr Ala Gly Arg Arg Pro Val Tyr Val Leu 
            100                 105                 110         


Cys Phe Gly Ile Tyr Ile Val Ala Asn Ile Gly Leu Ala Leu Gln Arg 
        115                 120                 125             


Asp Phe Val Thr Leu Leu Val Leu Arg Ala Leu Gln Ser Thr Gly Ile 
    130                 135                 140                 


Ser Ala Thr Val Ala Leu Ser Asn Ala Val Ala Ala Asp Thr Val Thr 
145                 150                 155                 160 


Ser Ala Glu Arg Gly Met Tyr Leu Gly Ile Ala Ser Leu Gly Gly Ile 
                165                 170                 175     


Leu Gly Pro Ala Leu Gly Pro Thr Leu Gly Gly Leu Leu Ser Gln Ser 
            180                 185                 190         


Leu Gly Trp Arg Ser Ile Phe Trp Phe Leu Ala Leu Val Ala Ala Val 
        195                 200                 205             


Phe Phe Val Leu Leu Met Leu Phe Phe Pro Glu Thr Cys Arg Ala Ile 
    210                 215                 220                 


Val Gly Asn Gly Ser Ile Pro Pro Pro Arg Trp Asn Arg Ser Leu Leu 
225                 230                 235                 240 


Asp Cys Met Val Gly Arg Thr Arg Gly Lys Gln Gln Leu Asn Leu Ser 
                245                 250                 255     


Pro Glu Ala Asp Asn Ala Pro Pro Lys Pro His Gln Lys Ser Arg Ile 
            260                 265                 270         


Arg Val Pro Asn Pro Trp Ser Thr Leu Arg Leu Leu Phe Glu Met Pro 
        275                 280                 285             


Thr Gly Leu Val Leu Leu Ser Asn Gly Ile Gly Tyr Ala Ala Tyr Tyr 
    290                 295                 300                 


Ala Val Thr Ser Thr Val Pro Thr Gln Trp Asn Glu Ile Tyr His Leu 
305                 310                 315                 320 


Asn Asp Phe Gln Leu Gly Leu Thr Tyr Ile Pro Ile Gly Leu Gly Thr 
                325                 330                 335     


Ile Leu Ser Ala Phe Thr Asn Gly Trp Leu Val Asp Trp Asn Phe Gln 
            340                 345                 350         


Arg Ile Ala Arg Gln Val Gly Gln Leu Pro Ile Arg Asn Gly Lys Gln 
        355                 360                 365             


Asp Leu Arg Gln Phe Pro Ile Glu Arg Ala Arg Leu Gln Ile Ala Met 
    370                 375                 380                 


Pro Ser Ala Met Leu Ala Ala Ala Ser Ile Ala Leu Tyr Gly Trp Val 
385                 390                 395                 400 


Ile Ala Ala Glu Arg Pro Ile Val Glu Ala Leu Ala Met Leu Leu Leu 
                405                 410                 415     


Ile Gly Tyr Leu Val Thr Ala Ser Tyr Asn Val Met Asn Val Leu Ile 
            420                 425                 430         


Val Asp Leu His Tyr Gly Lys Pro Ala Thr Ala Thr Ala Ala Asn Asn 
        435                 440                 445             


Leu Val Arg Cys Leu Leu Gly Ala Gly Ala Thr Ala Gly Val Thr Pro 
    450                 455                 460                 


Leu Leu Asp Leu Leu Gly Arg Gln Trp Cys Phe Cys Val Val Gly Ala 
465                 470                 475                 480 


Ile Tyr Val Ile Ser Leu Pro Leu Ser Gly Leu Val Tyr Gly Phe Gly 
                485                 490                 495     


Ala Gly Trp Arg Glu Lys Arg Asp Ala Glu Arg Asp Gly 
            500                 505                 


<210>  148
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 147

<400>  148

Met His Ser Val Met Ala Ser Ser Thr Lys Ile Pro Ile Pro Arg Val 
1               5                   10                  15      


Asn Arg Asp Glu Ala Thr Ala Leu Leu Ala Pro Pro Gln Ala Pro Tyr 
            20                  25                  30          


Gln Val Phe Ser Pro Val Gln Lys Lys Leu Ile Val Phe Thr Ala Ala 
        35                  40                  45              


Leu Ala Ser Thr Phe Val Pro Leu Ser Ser Asn Ile Tyr Tyr Pro Ala 
    50                  55                  60                  


Ile Asn Ser Ile Ala Asp Glu Leu Lys Ile Ser Pro Gly Met Val Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Ala Tyr Met Val Phe Gln Gly Leu Thr Pro Ala Phe 
                85                  90                  95      


Met Gly Asp Leu Ser Asp Thr Ala Gly Arg Arg Pro Val Tyr Val Leu 
            100                 105                 110         


Cys Phe Gly Ile Tyr Ile Val Ala Asn Ile Gly Leu Ala Leu Gln Arg 
        115                 120                 125             


Asp Phe Val Thr Leu Leu Val Leu Arg Ala Leu Gln Ser Thr Gly Ile 
    130                 135                 140                 


Ser Ala Pro Val Ala Leu Ser Asn Ala Val Ala Ala Asp Thr Val Thr 
145                 150                 155                 160 


Ser Ala Glu Arg Gly Met Tyr Leu Gly Ile Ala Ser Leu Gly Gly Ile 
                165                 170                 175     


Leu Gly Pro Ala Leu Gly Pro Thr Leu Gly Gly Leu Leu Ser Gln Ser 
            180                 185                 190         


Leu Gly Trp Arg Leu Ile Phe Trp Phe Leu Ala Leu Val Ala Ala Val 
        195                 200                 205             


Phe Phe Val Leu Leu Met Leu Phe Phe Pro Glu Thr Cys Arg Ala Ile 
    210                 215                 220                 


Val Gln Asn Gly Ser Ile Pro Pro Pro Arg Trp Asn Arg Ser Val Leu 
225                 230                 235                 240 


Asp Cys Met Val Gly Arg Asp Arg Gly Lys Gln Gln Leu Asn Leu Ser 
                245                 250                 255     


Pro Leu Ala Asp Asn Ala Pro Pro Lys Gln Phe Gln Lys Ala Arg Ile 
            260                 265                 270         


Arg Val Pro Asn Pro Tyr Ser Thr Leu Arg Leu Leu Phe Glu Met Pro 
        275                 280                 285             


Thr Gly Leu Val Leu Leu Ser Asn Gly Ile Gly Tyr Ala Ala Tyr Phe 
    290                 295                 300                 


Ala Val Thr Ser Thr Val Pro Ser Gln Trp Asn Glu Ile Tyr His Leu 
305                 310                 315                 320 


Asn Arg Pro Gln Leu Gly Leu Thr Tyr Ile Pro Ile Gly Leu Gly Thr 
                325                 330                 335     


Ile Leu Ser Ala Phe Thr Asn Gly Trp Leu Val Asp Trp Asn Phe Gln 
            340                 345                 350         


Arg Ile Gln Arg Gln Val Gly Gln Leu Pro Ile Arg Asn Gly Lys Gln 
        355                 360                 365             


Asp Leu Arg Gln Phe Pro Ile Glu Arg Ala Arg Leu Gln Ile Ala Met 
    370                 375                 380                 


Pro Ser Ala Met Leu Ala Ala Ala Ser Ile Ala Leu Tyr Gly Trp Val 
385                 390                 395                 400 


Val Ala Ser Glu Arg Pro Ile Val Glu Ala Leu Ala Met Leu Leu Leu 
                405                 410                 415     


Ile Gly Tyr Leu Val Thr Ala Ser Tyr Asn Val Met Leu Val Leu Ile 
            420                 425                 430         


Val Asp Leu His Tyr Gly Lys Pro Ala Thr Ala Thr Ala Ala Asn Gly 
        435                 440                 445             


Leu Val Trp Cys Leu Leu Gly Ala Gly Ala Thr Ala Gly Val Thr Pro 
    450                 455                 460                 


Leu Leu Asp Leu Leu Gly Arg Gln Trp Cys Phe Cys Val Val Gly Ala 
465                 470                 475                 480 


Ile Tyr Val Ile Ser Leu Pro Leu Ser Gly Leu Val Tyr Gly Phe Gly 
                485                 490                 495     


Ala Gly Trp Arg Glu Lys Arg Leu Ala Glu Arg Asp Gly 
            500                 505                 


<210>  149
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 147

<400>  149

Met His Ser Val Met Ala Ser Ser Thr Lys Ile Pro Ile Pro Arg Val 
1               5                   10                  15      


Thr Val Asp Pro His Gly Asn Leu Leu Ala Pro Pro Gln Ala Pro Tyr 
            20                  25                  30          


Gln Val Phe Ser Pro Val Gln Lys Asn Leu Ile Val Phe Thr Ala Ala 
        35                  40                  45              


Leu Ala Ser Thr Phe Ser Pro Leu Ser Leu Asn Ile Tyr Tyr Pro Ala 
    50                  55                  60                  


Ile Asn Ser Ile Ala Asp Glu Leu Lys Ile Ser Pro Gly Met Val Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Ala Tyr Met Val Phe Gln Gly Leu Thr Pro Ala Phe 
                85                  90                  95      


Met Gly Asp Leu Ser Asp Thr Ala Gly Arg Arg Pro Val Tyr Val Leu 
            100                 105                 110         


Cys Phe Gly Ile Tyr Ile Val Ala Asn Ile Gly Val Ala Leu Gln Arg 
        115                 120                 125             


Asp Phe Val Thr Leu Leu Val Leu Arg Ala Leu Gln Ser Thr Gly Ile 
    130                 135                 140                 


Ser Ala Thr Val Ala Leu Ser Asn Ala Val Ala Ala Asp Thr Val Thr 
145                 150                 155                 160 


Ser Ala Glu Arg Gly Met Tyr Leu Gly Ile Tyr Ser Leu Gly Gly Ile 
                165                 170                 175     


Leu Gly Pro Ala Leu Gly Pro Thr Leu Gly Gly Leu Leu Ser Gln Ser 
            180                 185                 190         


Leu Gly Trp Arg Trp Ile Phe Trp Phe Leu Ala Leu Val Ala Ala Val 
        195                 200                 205             


Phe Phe Val Leu Leu Met Leu Phe Phe Pro Glu Thr Cys Arg Ala Ile 
    210                 215                 220                 


Val Gly Asn Gly Ser Ile Pro Pro Pro Arg Trp Asn Ala Ser Glu Leu 
225                 230                 235                 240 


Asp Cys Met Val Gly Arg Thr Arg Gly Lys Gln Gln Leu Asn Leu Ser 
                245                 250                 255     


Pro Glu Ala Asp Met Leu Pro Pro Glu Pro Pro Gln Gln Val Arg Ile 
            260                 265                 270         


Arg Val Pro Asn Pro Trp Ser Thr Leu Arg Leu Leu Phe Glu Met Pro 
        275                 280                 285             


Thr Gly Leu Val Leu Leu Ser Asn Gly Ile Gly Tyr Ala Ala Tyr Tyr 
    290                 295                 300                 


Ala Val Thr Ser Thr Val Pro Thr Gln Trp Asn Glu Ile Tyr His Leu 
305                 310                 315                 320 


Asn Asp Phe Gln Leu Gly Leu Thr Tyr Ile Pro Ile Gly Leu Gly Thr 
                325                 330                 335     


Ile Leu Ser Gly Phe Thr Asn Gly Trp Leu Val Asp Trp Asn Phe Gln 
            340                 345                 350         


Arg Ile Ala Arg Gln Val Gly Ser Leu Pro Ile Arg Asn Gly Lys Gln 
        355                 360                 365             


Asp Leu Arg Gln Phe Pro Ile Glu Arg Ala Arg Leu Gln Ile Ala Met 
    370                 375                 380                 


Pro Ser Ala Met Leu Ala Ala Ala Ser Ile Ala Leu Tyr Gly Trp Val 
385                 390                 395                 400 


Ile Ala Ala Glu Arg Pro Ile Ala Glu Ala Leu Ala Met Leu Leu Leu 
                405                 410                 415     


Ile Gly Tyr Leu Val Thr Ala Ser Tyr Asn Val Met Asn Val Leu Ile 
            420                 425                 430         


Val Asp Leu His Tyr Gln Lys Pro Ala Thr Ala Thr Ala Ala Asn Asn 
        435                 440                 445             


Leu Val Leu Cys Leu Leu Gly Ala Gly Ala Thr Ala Gly Val Thr Pro 
    450                 455                 460                 


Leu Leu Asp Leu Leu Gly Arg His Trp Cys Phe Cys Val Val Gly Ala 
465                 470                 475                 480 


Ile Tyr Val Ile Ser Leu Pro Leu Ser Gly Leu Val Tyr Gly Phe Gly 
                485                 490                 495     


Arg Gly Trp Arg Glu Lys Arg Asp Ala Glu Arg Asp Gly 
            500                 505                 


<210>  150
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 147

<400>  150

Met His Ser Val Gln Met Ser Ser Thr Lys Ile Pro Ile Ala Arg Val 
1               5                   10                  15      


Pro Val Asp Glu Ala Leu Ala Leu Leu Ala Pro Pro Gln Pro Pro Tyr 
            20                  25                  30          


Glu Val Trp Ser Pro Gly Gln Lys Lys Leu Ile Val Phe Thr Ala Ala 
        35                  40                  45              


Leu Ala Tyr Thr Phe Ser Pro Leu Ser Ser Asn Ile Tyr Tyr Pro Ala 
    50                  55                  60                  


Ile Asn Leu Ile Ala Asp Glu Leu Lys Ile Ser Pro Gly Val Val Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Ala Tyr Met Val Phe Gln Gly Leu Thr Pro Ala Phe 
                85                  90                  95      


Met Gly Asp Leu Ser Asp Thr Ala Gly Arg Arg Pro Val Tyr Val Leu 
            100                 105                 110         


Cys Phe Gly Ile Tyr Ile Val Ala Asn Ile Gly Leu Ala Leu Gln Arg 
        115                 120                 125             


Asp Phe Ile Thr Leu Leu Val Leu Arg Ala Leu Gln Ser Thr Gly Ile 
    130                 135                 140                 


Ser Ala Thr Val Ala Leu Ser Asn Ala Val Ala Ala Asp Thr Val Thr 
145                 150                 155                 160 


Ser Ala Glu Arg Gly Met Tyr Leu Gly Ile Ala Glu Leu Gly Gly Ile 
                165                 170                 175     


Leu Gly Pro Ala Leu Gly Pro Thr Leu Gly Gly Leu Leu Ser Ala Ser 
            180                 185                 190         


Leu Gly Trp Arg His Ile Phe Trp Phe Leu Ala Leu Val Ala Ala Val 
        195                 200                 205             


Phe Phe Val Leu Leu Met Leu Phe Phe Pro Glu Thr Cys Ala Ala Ile 
    210                 215                 220                 


Val Gly Asn Gly Ser Ile Gly Pro Pro Arg Trp Asn Arg Ser Lys Leu 
225                 230                 235                 240 


Asp Cys Met Leu Gly Arg Thr Arg Gly Glu Gln Tyr Leu Asn Ser Gly 
                245                 250                 255     


Pro Ala Ala Asp Asn Ala Pro Pro Lys Pro His Gln Phe Ser Arg Ile 
            260                 265                 270         


Arg Val Pro Asn Pro Trp Ser Thr Leu Arg Leu Leu Phe Glu Met Pro 
        275                 280                 285             


Thr Gly Leu Val Leu Leu Ser Asn Gly Ile Gly Tyr Ala Ala Tyr Tyr 
    290                 295                 300                 


Ala Val Thr Ser Thr Val Pro Thr Gln Trp Asn Glu Ile Tyr His Leu 
305                 310                 315                 320 


Asn Asp Phe Gln Leu Gly Leu Thr Tyr Ile Pro Ile Gly Leu Gly Thr 
                325                 330                 335     


Ile Leu Ser Ala Phe Thr Asn Gly Asn Leu Val Asp Trp Asn Phe Gln 
            340                 345                 350         


Arg Ile Ala Arg Gln Val Gly Gln Leu Pro Ile Arg Asn Gly Lys Gln 
        355                 360                 365             


Asp Leu Arg Gln Phe Pro Ile Glu Arg Ala Arg Leu Gln Ile Ala Met 
    370                 375                 380                 


Pro Ser Ala Met Leu Ala Ala Ala Ser Ile Ala Leu Tyr Gly Trp Val 
385                 390                 395                 400 


Ser Ala Ala Glu Arg Pro Ile Val Glu Ala Leu Ala Met Leu Leu Leu 
                405                 410                 415     


Ile Gly Tyr Leu Val Thr Ala Ser Tyr Asn Val Met Leu Val Leu Ile 
            420                 425                 430         


Val Asp Leu Ser Tyr Gly Lys Pro Ala Thr Ala Thr Ala Ala Met Asn 
        435                 440                 445             


Leu Val Arg Cys Leu Leu Gly Ala Gly Ala Thr Ala Gly Val Thr Trp 
    450                 455                 460                 


Leu Leu Asp Val Leu Gly Gln Gln Arg Cys Phe Gly Val Val Gly Ala 
465                 470                 475                 480 


Ile Tyr Val Ile Ser Leu Pro Leu Ser Gly Leu Val Tyr Gly Phe Gly 
                485                 490                 495     


Ala Gly Trp Arg Glu Lys Arg Asp Pro Glu Arg Asp Gly 
            500                 505                 


<210>  151
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 147

<400>  151

Met His Ser Val Met Ala Ser Ser Thr Lys Ile Pro Ile Pro Arg Val 
1               5                   10                  15      


Thr Val Ile Glu Ala Thr Ala Met Leu Ala Pro Ala Gln Leu Pro Tyr 
            20                  25                  30          


Ser Val Phe Ser Pro Val Gln Lys Arg Leu Ile Val Phe Thr Ala Ala 
        35                  40                  45              


Leu Ala Ser Thr Phe Ser Pro Leu Thr Ser Gln Ile Tyr Tyr Pro Ala 
    50                  55                  60                  


Ile Asn Ser Ile Gln Asp Glu Leu Lys Ile Ser Pro Gly Met Val Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Ala Tyr Met Val Phe Gly Gly Leu Thr Pro Ala Phe 
                85                  90                  95      


Met Gly Asp Leu Ser Asp Thr Ala Gly Arg Arg Pro Val Tyr Val Leu 
            100                 105                 110         


Cys Phe Gly Ile Tyr Ile Val Ala Asn Ile Gly Leu Ala Leu Gln Arg 
        115                 120                 125             


Asp Phe Val Phe Leu Leu Val Leu Arg Ala Leu Trp Ser Thr Gly Leu 
    130                 135                 140                 


Ser Ala Leu Ser Ala Leu Ser Ile Ala Val Ala Ala Asp Thr Val Thr 
145                 150                 155                 160 


Ser Ala Glu Arg Gly Met Tyr Leu Gly Ile Ala Thr Leu Gly Gly Ala 
                165                 170                 175     


Leu Gly Pro Ala Leu Gly Pro Thr Leu Gly Gly Leu Leu Ser Gln Ser 
            180                 185                 190         


Leu Gly Trp Arg Ser Ile Phe Trp Phe Tyr Ala Leu Val Ala Ala Val 
        195                 200                 205             


Phe Phe Val Leu Leu Met Leu Phe Phe Pro Glu Thr Cys Arg Tyr Ile 
    210                 215                 220                 


Leu Ala Asn Gly Ser Ile Pro Pro Pro Gly Trp Asn Asn Ser Leu Leu 
225                 230                 235                 240 


Asp Cys Met Val Phe Arg Thr Arg Gly Lys Gln Gln Leu Asn Leu Ser 
                245                 250                 255     


Asn Leu Ala Asp Asn Ala Pro Pro Val Pro Glu Gln Lys Trp Arg Leu 
            260                 265                 270         


Glu Val Pro Asn Pro Leu Gln Thr Leu Arg Leu Leu Phe Glu Met Trp 
        275                 280                 285             


Thr Gly Leu Val Leu Leu Ser Asn Gly Ile Gly His Ala Ala Tyr Tyr 
    290                 295                 300                 


Ala Val Thr Ser Thr Val Pro Thr Gln Trp Leu Glu Ile Tyr His Leu 
305                 310                 315                 320 


Asn Asp Phe Gln Leu Gly Leu Thr Tyr Ile Pro Tyr Gly Leu Gly Thr 
                325                 330                 335     


Ile Leu Ser Ala Phe Thr Asn Gly Trp Leu Val Asp Trp Asn Phe Gln 
            340                 345                 350         


Arg Lys Ala Arg Gln Val Gly Gln Leu Pro Ile Arg Asn Gly Lys Gln 
        355                 360                 365             


Asp Leu Arg Gln Phe Pro Ile Glu Arg Tyr Arg Leu Gln Ile Ala Met 
    370                 375                 380                 


Pro Ser Ala Met Leu Gly Ala Ala Ser Ile Ala Leu Tyr Gly Trp Val 
385                 390                 395                 400 


Arg Asn Ala Glu Glu Pro Ile Val Glu Ala Leu Ala Met Leu Leu Leu 
                405                 410                 415     


Ile Gly Tyr Leu Tyr Thr Ala Ser Tyr Asn Val Leu Asn Val Leu Ile 
            420                 425                 430         


Ala Asp Leu His Tyr Glu Lys Pro Ala Thr Ala Thr Ala Ala Asn Asn 
        435                 440                 445             


Leu Val Arg Cys Leu Leu Gly Ala Gly Ala Thr Ala Gly Val Thr Pro 
    450                 455                 460                 


Leu Leu Asp His Leu Gly Tyr Gln Trp Cys Phe Cys Val Val Gly Ala 
465                 470                 475                 480 


Ile Tyr Val Ile Ser Leu Pro Leu Ser Gly Leu Val Tyr Gly Phe Ser 
                485                 490                 495     


Ala Gly Trp Arg Glu Lys Arg Asp Ala Glu Arg Glu Gly 
            500                 505                 


<210>  152
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 147

<400>  152

Met His Ser Gly Asp Met Ser Ala Thr Pro Ala Pro Ile Pro Arg Val 
1               5                   10                  15      


Thr His Asp Ala Ala Thr Ala Glu Leu Ser Pro Pro Gln Pro Pro Tyr 
            20                  25                  30          


Ser Glu Phe Thr Pro Val Gln Lys Lys Leu Ile Val Phe Thr Ala Ala 
        35                  40                  45              


Leu Ala Thr Thr Phe Ser Pro Leu Ser Ser Asn Ile Tyr Tyr Pro Ala 
    50                  55                  60                  


Ile Asn Ser Ile Ala Gln Glu Leu Lys Ile Ser Pro Gly Met Val Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Ala Tyr Met Val Phe Gln Gly Leu Thr Pro Ala Phe 
                85                  90                  95      


Met Gly Asp Leu Ser Asp Thr Ala Gly Arg Arg Pro Val Tyr Val Leu 
            100                 105                 110         


Cys Phe Gly Ile Tyr Ile Val Ala Thr Ile Gly Leu Ala Leu Gln Arg 
        115                 120                 125             


Asp Phe Thr Gly Leu Leu Val Leu Arg Ala Leu Gln Ser Thr Gly Glu 
    130                 135                 140                 


Ser Ala Thr Val Ala Leu Ser Arg Ala Val Ala Ala Asp Thr Val Thr 
145                 150                 155                 160 


Ser Ala Tyr Arg Gly Leu Tyr Leu Gly Ile Ala Thr Leu Gly Gly Ile 
                165                 170                 175     


Leu Gly Pro Ala Leu Gly Pro Thr Leu Gly Gly Leu Leu Ser Gln Ser 
            180                 185                 190         


Leu Gly Trp Arg Ser Ile Phe Trp Phe Asn Ala Leu Val Ala Ala Val 
        195                 200                 205             


Phe Phe Val Leu Leu Met Leu Phe Phe Pro Glu Thr Cys Arg Ala Arg 
    210                 215                 220                 


Val Ser Asn Gly Ser Ile Asn Gln Pro Arg Trp Asn Arg Ser Leu Leu 
225                 230                 235                 240 


Asp Cys Met Val Gly Arg Lys Pro Gly Lys Gln Gln Leu Asn Leu Ser 
                245                 250                 255     


Pro Glu Ala Asp Phe Ala Pro Pro Lys Pro His Gln Leu Ser Arg Phe 
            260                 265                 270         


Arg Val Pro Asn Pro Trp Ser Thr Ile Glu Leu Leu Phe Glu Met Pro 
        275                 280                 285             


Thr Gly Leu Val Leu Leu Ser Asn Gly Ile Gly Tyr Ala Ala Met Tyr 
    290                 295                 300                 


Ala Val Thr Ser Thr Val Pro Thr Gln Trp His Glu Ile Tyr His Leu 
305                 310                 315                 320 


Asn Asp Val Gln Leu Gly Leu Thr Tyr Ile Pro Ile Gly Leu Gly Thr 
                325                 330                 335     


Ile Leu Ser Asn Phe Thr Asn Gly Trp Leu Val Asp Trp Asn Phe Gln 
            340                 345                 350         


Arg Tyr Lys Arg Gln Val Gly Gln Leu Pro Ile Arg Asn Gly Lys Gln 
        355                 360                 365             


Asp Leu Arg Gln Phe Pro Ile Glu Arg Ala Arg Leu Gln Ile Ala Met 
    370                 375                 380                 


Pro Ser Ala Met Leu Ala Ala Ala Ser Ile Ala Leu Tyr Gly Trp Val 
385                 390                 395                 400 


Gly Ala Lys Glu Pro Pro Ile Pro Glu Ala Leu Ala Met Leu Leu Leu 
                405                 410                 415     


Ile Gly Tyr Leu Val Thr Ala Ser Asn Asn Val Met Asn Val Leu Ile 
            420                 425                 430         


Gln Asp Leu His Tyr Gly Lys Pro Ala Thr Ala Thr Ala Ala Trp Asn 
        435                 440                 445             


Leu Val Glu Cys Leu Leu Gly Ala Gly Ala Thr Ala Gly Val Thr Pro 
    450                 455                 460                 


Leu Leu Asp Leu Phe Gly Arg Gln Trp Cys Phe Cys Val Val Gly Ala 
465                 470                 475                 480 


Ile Tyr Val Ile Ser Leu Pro Leu Ser Gly Leu Val Tyr Gly Phe Gly 
                485                 490                 495     


Ala Gly Trp Arg Glu Lys Arg Gly Ala Pro Arg Asp Gly 
            500                 505                 


<210>  153
<211>  732
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  153
atgctgacca ccgtcaagac gcccaatgcc gtacagaaca tcgagatcct cgcgcgccgg       60

tatggggaca ttcaagccaa cgccgccaac atcaacaccc cgtgcgattg catccatggc      120

atggtgcagg tgatggggaa gctgccagat cactacccgg tctcctttga tacgatcctg      180

agtttgggcg ccgatatcac cacccagtgt gcgcacatgg tggcctgcga gcactgccgg      240

acccactggc atgccatcat caccctacag tgcgtcctcg atctggggtt ggccctgtat      300

gagggggcct tttccgccta tgcattggga gaaggggatc tgaggagccc ggagcggttg      360

ggcaccgggc ggagatcccg ctcctcgacg ctgtcccttc ctcggccacc tggctcctcc      420

tccgatggag cagacggtct ggccagcgcg gacgatttcc ccgggacgat gaacgggccc      480

ccggtctgtt gcaccagccc gatgacatgg ggcgatatcg agatccatga agaagacgcg      540

caactgctcg ccggcatgct cctgcgccgg cgattggcgg acctgggggc cctgatcggc      600

gagctgaaac tcatcctgga gaatgtgtgg catcggaatc gcccccaaca atccttctcg      660

ctgcaggagt gcgaggactc tctgatggtg tcgatggacc ggctagtgac gttggtcggg      720

cttttgagat ga                                                          732


<210>  154
<211>  243
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  154

Met Leu Thr Thr Val Lys Thr Pro Asn Ala Val Gln Asn Ile Glu Ile 
1               5                   10                  15      


Leu Ala Arg Arg Tyr Gly Asp Ile Gln Ala Asn Ala Ala Asn Ile Asn 
            20                  25                  30          


Thr Pro Cys Asp Cys Ile His Gly Met Val Gln Val Met Gly Lys Leu 
        35                  40                  45              


Pro Asp His Tyr Pro Val Ser Phe Asp Thr Ile Leu Ser Leu Gly Ala 
    50                  55                  60                  


Asp Ile Thr Thr Gln Cys Ala His Met Val Ala Cys Glu His Cys Arg 
65                  70                  75                  80  


Thr His Trp His Ala Ile Ile Thr Leu Gln Cys Val Leu Asp Leu Gly 
                85                  90                  95      


Leu Ala Leu Tyr Glu Gly Ala Phe Ser Ala Tyr Ala Leu Gly Glu Gly 
            100                 105                 110         


Asp Leu Arg Ser Pro Glu Arg Leu Gly Thr Gly Arg Arg Ser Arg Ser 
        115                 120                 125             


Ser Thr Leu Ser Leu Pro Arg Pro Pro Gly Ser Ser Ser Asp Gly Ala 
    130                 135                 140                 


Asp Gly Leu Ala Ser Ala Asp Asp Phe Pro Gly Thr Met Asn Gly Pro 
145                 150                 155                 160 


Pro Val Cys Cys Thr Ser Pro Met Thr Trp Gly Asp Ile Glu Ile His 
                165                 170                 175     


Glu Glu Asp Ala Gln Leu Leu Ala Gly Met Leu Leu Arg Arg Arg Leu 
            180                 185                 190         


Ala Asp Leu Gly Ala Leu Ile Gly Glu Leu Lys Leu Ile Leu Glu Asn 
        195                 200                 205             


Val Trp His Arg Asn Arg Pro Gln Gln Ser Phe Ser Leu Gln Glu Cys 
    210                 215                 220                 


Glu Asp Ser Leu Met Val Ser Met Asp Arg Leu Val Thr Leu Val Gly 
225                 230                 235                 240 


Leu Leu Arg 
            


<210>  155
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 154

<400>  155

Met Leu Thr Thr Val Lys Thr Pro Asn Ala Val Gln Asn Ile Glu Ile 
1               5                   10                  15      


Leu Ala Arg Arg Tyr Gly Asp Ile Gln Ala Asn Ala Ala Asn Ile Asn 
            20                  25                  30          


Thr Pro Cys Asp Cys Ile His Gly Met Val Gln Val Met Gly Glu Leu 
        35                  40                  45              


Pro Asp His Tyr Pro Val Ser Phe Asp Thr Ile Leu Ser Leu Gly Ala 
    50                  55                  60                  


Asp Ile Thr Thr Gln Cys Asn His Met Val Ala Cys Glu His Cys Glu 
65                  70                  75                  80  


Thr His Trp His Ala Ile Ile Thr Leu Gln Cys Val Leu Asp Leu Gly 
                85                  90                  95      


Leu Ala Leu Tyr Glu Glu Ala Phe Ser Ala Tyr Gln Leu Gly Glu Gly 
            100                 105                 110         


Asp Leu Arg Ser Pro Glu Arg Leu Gly Thr Gly Arg Arg Ser Arg Ser 
        115                 120                 125             


Ser Thr Leu Ser Leu Pro Arg Pro Pro Gly Ser Ser Ser Gly Gly Ala 
    130                 135                 140                 


Asp Gly Leu Ala Ser Ala Asp Asp Phe Pro Gly Thr Met Asn Gly Pro 
145                 150                 155                 160 


Pro Val Cys Cys Thr Ser Pro Met Thr Trp Gly Asp Ile Glu Ile His 
                165                 170                 175     


Glu Glu Asp Ala Gln Leu Leu Ala Lys Tyr Leu Leu Thr Lys Arg Leu 
            180                 185                 190         


Asp Asp Leu Gly Glu Leu Ile Gly Glu Leu Lys Leu Ile Leu Glu Asn 
        195                 200                 205             


Val Trp His Arg Asn Arg Gln Gln Gln Ser Phe Ser Leu Gln Glu Cys 
    210                 215                 220                 


Glu Asp Ser Leu Met Val Ser Met Asp Arg Leu Val Thr Leu Val Gly 
225                 230                 235                 240 


Leu Leu Arg 
            


<210>  156
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 154

<400>  156

Met Leu Thr Thr Val Lys Thr Pro Asn Ala Val Gln Asn Ile Glu Ile 
1               5                   10                  15      


Leu Ala Arg Asp Tyr Gly Asp Ile Gln Ala Asn Ala Ala Asn Ile Asn 
            20                  25                  30          


Thr Pro Cys Asp Cys Ile Ser Gly Met Val Gln Val Met Gly Lys Leu 
        35                  40                  45              


Pro Asp Pro Tyr Pro Val Ser Phe Asp Thr Ile Leu Ser Leu Gly Ala 
    50                  55                  60                  


Asp Ile Thr Thr Gln Cys Ala His Met Val Ala Cys Glu His Cys Val 
65                  70                  75                  80  


Thr His Trp Arg Ala Ile Ile Thr Leu Gln Cys Val Leu Asp Leu Gly 
                85                  90                  95      


Leu Ala Leu Tyr Glu Gly Ala Phe Ser Ala Cys Ala Leu Gly Glu Gly 
            100                 105                 110         


Asp Leu Arg Ser Pro Glu Arg Leu Gly Thr Gly Arg Arg Ser Arg Ser 
        115                 120                 125             


Ser Trp Leu Ser Leu Pro Arg Pro Pro Gly Ser Ser Ser Asp Gly Ala 
    130                 135                 140                 


Asp Gly Leu Ala Ser Ala Asp Asp Phe Pro Gly Thr Met Asn Gly Pro 
145                 150                 155                 160 


Pro Val Cys Cys Thr Ser Pro Met Thr Trp Gly Glu Ile Glu Ile Asn 
                165                 170                 175     


Glu Glu Asp Ala Gln Leu Leu Ala Gly Met Leu Leu Arg Arg Arg Leu 
            180                 185                 190         


Ala Asp Leu Lys Ala Asp Ile Glu Glu Leu Tyr Leu Ile Leu Glu Asn 
        195                 200                 205             


Val Trp His Arg Asn Arg Pro Gln Gln Ser Phe Ser Leu Gln Glu Cys 
    210                 215                 220                 


Glu Asp Ser Leu Met Val Ser Met Asp Arg Leu Val Thr Leu Val Gly 
225                 230                 235                 240 


Leu Leu Arg 
            


<210>  157
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 154

<400>  157

Met Leu Thr Thr Val Lys Thr Pro Asn Ala Val Gln Asn Ile Glu Ile 
1               5                   10                  15      


Leu Ala Arg Arg Tyr Gly Asp Ile Gln Ala Asn Ala Ala Asn Ile Asn 
            20                  25                  30          


Thr Pro Cys Asp Cys Ile His Glu Met Val Gln Val Met Gly Lys Leu 
        35                  40                  45              


Pro Asp His Tyr Pro Val Ser Phe Asp Thr Ile Leu Ser Leu Asp Ala 
    50                  55                  60                  


Asp Ile Thr Thr Gln Cys Ala His Met Val Ala Cys Glu His Cys Lys 
65                  70                  75                  80  


Thr His Trp His Ala Ile Ile Thr Leu Gln Ala Val Leu Asp Leu Gly 
                85                  90                  95      


Leu Gln Leu Tyr Glu Gly Ala Phe Ser Ala Tyr Ala Leu Gly Glu Gly 
            100                 105                 110         


Asp Leu Arg Ser Pro Glu Arg Leu Gly Glu Gly Arg Arg Ser Arg Ser 
        115                 120                 125             


Ser Thr Ser Ser Arg Pro Arg Pro Pro Gly Ser Ser Ser Asp Gly Ala 
    130                 135                 140                 


Asp Gly Leu Ala Ser Ala Ser Asp Phe Pro Glu Thr Met Asn Gly Pro 
145                 150                 155                 160 


Pro Phe Cys Cys Arg Ser Pro Met Thr Trp Gly Trp Ile Glu Ile His 
                165                 170                 175     


Glu Glu Asp Gly Gln Leu Leu Ala Gly Met Leu Leu Arg Arg Arg Leu 
            180                 185                 190         


Ala Asp Leu Gly Lys Leu Ile Glu Glu Leu Lys Leu Lys Leu Glu Asn 
        195                 200                 205             


Val Trp His Arg Asn Arg Pro Gln Gln Ser Phe Ser Leu Gln Glu Cys 
    210                 215                 220                 


Glu Asp Ser Leu Met Leu Ser Met Asp Arg Leu Val Thr Leu Val Gly 
225                 230                 235                 240 


Leu Leu Arg 
            


<210>  158
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 154

<400>  158

Met Leu Thr Thr Val Lys Thr Pro Asn Ala Val Gln Asn Ile Glu Ile 
1               5                   10                  15      


Leu Ala Arg Arg Tyr Gly Asp Ile Gln Ala Asn Ala Ala Asn Ile Asn 
            20                  25                  30          


Pro Pro Cys Asp Cys Ile Thr Gly Met Val Gln Val Met Gly Lys Leu 
        35                  40                  45              


Pro Asp His Tyr Pro Val Ser Phe Asp Thr Ile Leu Ser Leu Gly Ala 
    50                  55                  60                  


Asp Ile Thr Thr Gln Cys Ala Thr Met Val Ala Cys Glu His Cys Val 
65                  70                  75                  80  


Thr His Trp Val Ala Ile Ile Thr Leu Gln Cys Val Leu Asp Leu Gly 
                85                  90                  95      


Leu Ala Leu Tyr Glu Ser Ala Phe Ser Ala Pro Ala Leu Gly Thr Gly 
            100                 105                 110         


Asp Leu Pro Ser Pro Glu Arg Leu Gly Thr Gly Arg Arg Ser Arg Ser 
        115                 120                 125             


Ser Ser Ala Ser Leu Pro Arg Pro Pro Gly Ser Ser Ser Arg Gly Ala 
    130                 135                 140                 


Asp Asp Leu Ala Ser Ala His Asp Phe Pro Gly Thr Leu Asn Gly Pro 
145                 150                 155                 160 


Pro Val Cys Cys Ala Ser Pro Met Thr Trp Gly Asp Ile Glu Ile His 
                165                 170                 175     


Glu Lys Asp Ala Arg Leu Leu Ala Gly Ala Leu Leu Arg Arg Arg Leu 
            180                 185                 190         


Val Asp Leu Glu Lys Leu Ile Gly Glu Leu Ser Leu Ile Leu Glu Asn 
        195                 200                 205             


Val Ala His Arg Asn Arg Pro Gln Gln Ser Phe Ser Leu Gln Glu Cys 
    210                 215                 220                 


Glu Asp Ser Leu Ser Val Ser Met Asp Arg Leu Val Thr Leu Val Gly 
225                 230                 235                 240 


Leu Leu Arg 
            


<210>  159
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 154

<400>  159

Met Leu Thr Thr Val Lys Thr Pro Asn Ala Val Gln Asn Ile Glu Ile 
1               5                   10                  15      


Leu Ala Arg Ser Tyr Gly Asp Ile Gln Ala Asn Ala Ala Asn Ile Asn 
            20                  25                  30          


Thr Pro Cys Asp Cys Ile His Gly Met Val Gln Val Met Gly Lys Leu 
        35                  40                  45              


Pro Asp His Tyr Pro Val Ser Phe Asp His Ile Leu Ser Leu Val Ala 
    50                  55                  60                  


Asp Ile Met Thr Thr Cys Tyr His Met Val Ala Cys Lys His Cys Arg 
65                  70                  75                  80  


Thr His Trp His Ala Ile Ile Thr Leu Gln Cys Val Leu Asp Leu Gly 
                85                  90                  95      


Leu Phe Leu Tyr Glu Gly Ala Tyr Ser Ala Tyr Ala Leu Gly Val Gly 
            100                 105                 110         


Asp Leu Asp Ser Pro Glu Arg Leu Gly Thr Gly Arg Arg Ser Arg Ser 
        115                 120                 125             


Ser Thr Leu Ser Leu Pro Arg Pro Pro Gly Ser Ser Ser Asp Gly Ala 
    130                 135                 140                 


Met Ala Leu Ala Ser Ala Asp Asp Phe Pro Pro Thr Met Asn Lys Pro 
145                 150                 155                 160 


Pro Val Cys Val Thr Glu Pro Met Thr Trp Gly Asp Ile Glu Ile His 
                165                 170                 175     


Glu Glu Asp Ala Arg Leu Leu Ala Gly Ala Leu Leu Arg Arg His Leu 
            180                 185                 190         


Ala Asp Leu Gly Ala Leu Ile Gly Glu Leu Lys Leu Ile Leu Glu Asn 
        195                 200                 205             


Val Trp His Arg Asn Arg Asp Ile Gln Asp Phe Ser Leu Gln Glu Cys 
    210                 215                 220                 


Glu Asp Ser Leu Ala Arg Ser Met Asp Arg Leu Val Thr Leu Val Gly 
225                 230                 235                 240 


Leu Leu Arg 
            


<210>  160
<211>  1020
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  160
atgtcgcaca agctttctct gaatgatggc gtcttaatgc ccacagtaag tactaccaga       60

tcctttttgt cattttgaat tgcatggtgc ttatggaata ctgctttttt agcttgcatt      120

tggcgtgggc actgctttct tgaaacgttc tggatcggat gccctgcatc gaccgacggt      180

ggatgccgtc aaagaagccc tccgtgtcgg ctatcgccac ctcgataccg ctgagatgta      240

caatacagag ctcgaagtgg gtgcggccat ccacgaaagc attgcggagg gcattgtcca      300

gggaagagat gagctgttca tcacgacaaa ggtctccagt gacttcctta acatctccaa      360

gtcgattgat gtcagcctcc aaaaattgaa attagattac gttgacgcgt aagtcattcc      420

cccctgcaga gaaatagctc ctatcgatcc tagccttgat ctgtctacag gtatctcatt      480

cataccccgt actgggcgga atccgacgac gacctgcaga aggcctggaa aggcatggag      540

gaggtcaagg ccagtgggaa ggcccgaacc attggtgtct cgaatttcca gtcgacgcat      600

ctccggaccg ttttggcaac cgcgcaaaca ccaccctcgg tgaatcagct cgaattccac      660

ccatatctct cggttcgaga tggcaacgac tatctcttca gcctacgaga caatatgcgg      720

gacatcacca tctccgctta tggcgccctg gcgccaatca caaggaatat cccgggccca      780

ctcgacgaga ctttgaaaga agtggccaac aggtatggcg tgggcactga tctggtgtgt      840

ctcagatggt gtattgagca gggggttgcc acgatcacaa ccagtcgcca tgaggaccga      900

atgaaggggt atctcagggt cttcgacttc cagatcacac cggacgaggt gatgcagatc      960

ggagcttcgg cccaggcatg tctgggggac aaagagcagc ccctcactcg gattgaaaaa     1020


<210>  161
<211>  305
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  161

Met Ser His Lys Leu Ser Leu Asn Asp Gly Val Leu Met Pro Thr Leu 
1               5                   10                  15      


Ala Phe Gly Val Gly Thr Ala Phe Leu Lys Arg Ser Gly Ser Asp Ala 
            20                  25                  30          


Leu His Arg Pro Thr Val Asp Ala Val Lys Glu Ala Leu Arg Val Gly 
        35                  40                  45              


Tyr Arg His Leu Asp Thr Ala Glu Met Tyr Asn Thr Glu Leu Glu Val 
    50                  55                  60                  


Gly Ala Ala Ile His Glu Ser Ile Ala Glu Gly Ile Val Gln Gly Arg 
65                  70                  75                  80  


Asp Glu Leu Phe Ile Thr Thr Lys Val Ser Ser Asp Phe Leu Asn Ile 
                85                  90                  95      


Ser Lys Ser Ile Asp Val Ser Leu Gln Lys Leu Lys Leu Asp Tyr Val 
            100                 105                 110         


Asp Ala Tyr Leu Ile His Thr Pro Tyr Trp Ala Glu Ser Asp Asp Asp 
        115                 120                 125             


Leu Gln Lys Ala Trp Lys Gly Met Glu Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140                 


Ala Arg Thr Ile Gly Val Ser Asn Phe Gln Ser Thr His Leu Arg Thr 
145                 150                 155                 160 


Val Leu Ala Thr Ala Gln Thr Pro Pro Ser Val Asn Gln Leu Glu Phe 
                165                 170                 175     


His Pro Tyr Leu Ser Val Arg Asp Gly Asn Asp Tyr Leu Phe Ser Leu 
            180                 185                 190         


Arg Asp Asn Met Arg Asp Ile Thr Ile Ser Ala Tyr Gly Ala Leu Ala 
        195                 200                 205             


Pro Ile Thr Arg Asn Ile Pro Gly Pro Leu Asp Glu Thr Leu Lys Glu 
    210                 215                 220                 


Val Ala Asn Arg Tyr Gly Val Gly Thr Asp Leu Val Cys Leu Arg Trp 
225                 230                 235                 240 


Cys Ile Glu Gln Gly Val Ala Thr Ile Thr Thr Ser Arg His Glu Asp 
                245                 250                 255     


Arg Met Lys Gly Tyr Leu Arg Val Phe Asp Phe Gln Ile Thr Pro Asp 
            260                 265                 270         


Glu Val Met Gln Ile Gly Ala Ser Ala Gln Ala Cys Leu Gly Asp Lys 
        275                 280                 285             


Glu Gln Pro Leu Thr Arg Ile Glu Lys Tyr His Met Ala Gln Lys His 
    290                 295                 300                 


Thr 
305 


<210>  162
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 161

<400>  162

Met Ser His Lys Leu Ser Leu Asn Asp Gly Val Leu Met Pro Thr Leu 
1               5                   10                  15      


Ala Phe Gly Val Gly Thr Asp Phe Leu Lys Arg Ser Gly Ser Asp Ala 
            20                  25                  30          


Leu His Arg Pro Thr Val Asp Ala Val Lys Glu Ala Leu Arg Val Gly 
        35                  40                  45              


Tyr Arg His Leu Asp Thr Ala Glu Met Tyr Asn Thr Glu Ala Val Val 
    50                  55                  60                  


Gly Ala Ala Ile His Glu Asp Ile Ala Glu Gly Ile Val Gln Gly Arg 
65                  70                  75                  80  


Asp Glu Leu Phe Ile Thr Thr Lys Val Ser Ser Asp Arg Leu Gln Ile 
                85                  90                  95      


Ser Lys Ser Ile Asp Val Ser Leu Gln Lys Leu Lys Leu Asp Tyr Val 
            100                 105                 110         


Asp Ala Tyr Leu Ile His Thr Pro Tyr Glu Ala Glu Ser Asp Asp Asp 
        115                 120                 125             


Leu Asp Lys Ala Trp Lys Gly Met Glu Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140                 


Ala Arg Thr Ile Gly Val Ser Asn Phe Gln Ser Glu His Leu Arg Thr 
145                 150                 155                 160 


Val Leu Ala Tyr Ala Gln Thr Pro Pro Ser Val Asn Gln Leu Glu Phe 
                165                 170                 175     


His Pro Tyr Leu Ser Val Ile Asp Gly Asn Asp Tyr Leu Phe Ser Leu 
            180                 185                 190         


Arg Asp Asn Met Arg Asp Ile Thr Ile Ser Ala Tyr Gly Ala Leu Ala 
        195                 200                 205             


Pro Ile Thr Arg Asn Ile Gly Ile Gln Arg Asp Glu Thr Leu Lys Glu 
    210                 215                 220                 


Val Ala Asn Arg Tyr Gly Val Gly Thr Asp Leu Val Cys Leu Arg Trp 
225                 230                 235                 240 


Cys Ile Glu Gln Gly Val Ala Thr Ile Thr Thr Ser Arg His Glu Asp 
                245                 250                 255     


Arg Met Lys Gly Tyr Leu Arg Val Leu Asp Phe Gln Ile Thr Pro Asp 
            260                 265                 270         


Glu Val Met Gln Ile Gly Ala Ser Ala Gln Ala Cys Leu Gly Asp Lys 
        275                 280                 285             


Glu Gln Pro Leu Thr Arg Ile Glu Lys Tyr His Met Ala Gln Lys His 
    290                 295                 300                 


Thr 
305 


<210>  163
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 161

<400>  163

Met Ser His Lys Leu Ser Leu Asn Asp Gly Val Leu Met Pro Thr Leu 
1               5                   10                  15      


Ala Phe Gly Val Gly Thr Ala Phe Leu Lys Arg Asn Gly Arg Tyr Ala 
            20                  25                  30          


Phe His Arg Pro Thr Val Asp Ala Val Lys Glu Ala Leu Arg Val Gly 
        35                  40                  45              


Tyr Arg His Leu Asp Thr Ala Glu Met Tyr Asn Thr Glu Leu Glu Val 
    50                  55                  60                  


Gly Ala Ala Ile His Glu Ser Ile Tyr Glu Gly Ile Val Gln Gly Arg 
65                  70                  75                  80  


Asp Glu Leu Phe Ile Thr Thr Lys Val Ser Ser Asp Phe Leu Asn Ile 
                85                  90                  95      


Ser Lys Ser Ile Asp Val Ser Leu Gln Lys Leu Lys Leu Asp Tyr Val 
            100                 105                 110         


Asp Ala Tyr Leu Ile His Thr Pro Tyr Ile Ala Glu Ser Asp Asp Asp 
        115                 120                 125             


Leu Gln Lys Ala Trp Lys Gly Met Glu Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140                 


Ala Arg Thr Ile Gly Val Ser Asn Phe Gln Ser Lys His Leu Arg Thr 
145                 150                 155                 160 


Val Leu Ala Thr Ala Gln Glu Lys Pro Ser Val Asn Gln Leu Glu Phe 
                165                 170                 175     


His Pro Tyr Leu Glu Gln Arg Asp Gly Asn Asp Tyr Leu Ser Ser Leu 
            180                 185                 190         


Arg Asp Asn Met Arg Asp Ile Thr Ile Ser Ala Tyr Gly Ala Leu Ala 
        195                 200                 205             


Pro Ile Thr Arg Asn Ile Ala Gly Lys Leu Asp Glu Phe Leu Lys Glu 
    210                 215                 220                 


Val Ala Asn Arg Tyr Gly Val Gly Thr Asp Leu Val Cys Leu Arg Trp 
225                 230                 235                 240 


Cys Ile Glu Gln Gly Val Ala Thr Ile Thr Thr Ser Arg His Glu Asp 
                245                 250                 255     


Arg Met Lys Gly Tyr Leu Arg Val Phe Asp Phe Gln Ile Thr Pro Asp 
            260                 265                 270         


Glu Val Met Gln Ile Gly Ala Ser Ala Gln Ala Cys Leu Gly Asp Lys 
        275                 280                 285             


Ala Gln Pro Leu Thr Arg Ile Glu Lys Tyr His Met Ala Gln Lys His 
    290                 295                 300                 


Thr 
305 


<210>  164
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 161

<400>  164

Met Ser His Lys Leu Ser Leu Asn Asp Gly Val Leu Met Pro Ile Leu 
1               5                   10                  15      


Ala Phe Gly Val Gly Thr Phe Phe Leu Lys Trp Ser Gly Ser Pro Lys 
            20                  25                  30          


Leu His Arg Pro Thr Val Asp Ala Val Lys Glu Ala Leu Arg Val Gly 
        35                  40                  45              


Tyr Arg His Leu Asp Thr Ala Glu Ala Tyr Asn Thr Glu Leu Ala Val 
    50                  55                  60                  


Gly Ala Ala Ile His Glu Cys Ile Ala Glu Gly Ile Val Gln Asn Arg 
65                  70                  75                  80  


Asp Glu Leu Phe Ile Thr Thr Lys Val Ser Ser Asp Phe Leu Ser Ile 
                85                  90                  95      


Ser Lys Ser Ile Asp Val Ser Leu Gln Lys Leu Lys Leu Asp Tyr Val 
            100                 105                 110         


Asp Ala Tyr Leu Ile His Thr Pro Val Leu Ala Glu Ser Leu Asp Asp 
        115                 120                 125             


Leu Gln Lys Ala Trp Lys Gly Met Glu Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140                 


Ala Arg Thr Ile Gly Val Ser Asn Phe Thr Ser Thr His Leu Arg Thr 
145                 150                 155                 160 


Val Leu Ala Phe Ala Gln Thr Pro Pro Ser Val Asn Gln Leu Glu Phe 
                165                 170                 175     


His Pro Tyr Arg Ser Val Pro Asp Gly Asn Asp Tyr Leu Phe Ser Leu 
            180                 185                 190         


Arg Asp Asn Met Arg Asp Ile Thr Ile Ser Ala Tyr Gly Ala Leu Ala 
        195                 200                 205             


Pro Ile Thr Arg Asn Ile Pro Gly Pro Leu Asp Glu Thr Leu Lys Val 
    210                 215                 220                 


Val Ala Asn Arg Tyr Gly Val Gly Thr Asp Leu Val Cys Leu Arg Trp 
225                 230                 235                 240 


Cys Ile Glu Gln Gly Val Ala Thr Ile Thr Thr Ser Arg His Glu Asp 
                245                 250                 255     


Arg Met Lys Gly Tyr Leu Arg Val Phe Asp Phe Gln Ile Thr Pro Asp 
            260                 265                 270         


Glu Val Met Lys Ile Gly Ala Ser Ala Gln Ala Cys Leu Gly Pro Lys 
        275                 280                 285             


Tyr Gln Pro Ala Thr Arg Ile Glu Lys Tyr His Met Ala Gln Lys His 
    290                 295                 300                 


Thr 
305 


<210>  165
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 161

<400>  165

Met Ser His Lys Leu Asn Leu Asn Asp Gly Val Leu Met Pro Thr Leu 
1               5                   10                  15      


Ala Phe Gly Val Gly Thr Ala Phe Arg Lys Asn Ser Glu Ser Asp Ala 
            20                  25                  30          


Leu His Arg Pro Thr Ala Asp Ala Val Lys Glu Ala Leu Arg Val Gly 
        35                  40                  45              


Tyr Arg His Leu Asp Thr Ala Glu Met Tyr Asn Thr Glu Ser Glu Val 
    50                  55                  60                  


Gly Ala Ala Ile His Glu Asn Ile Ala Glu Gly Ile Lys Ala Gly Arg 
65                  70                  75                  80  


Asp Glu Leu Phe Ile Thr Thr Lys Val Ser Ala Asp Phe Leu Val Ile 
                85                  90                  95      


Ser Lys Ser Ile Asp Val Ser Leu Gln Lys Leu Lys Leu Asp Tyr Val 
            100                 105                 110         


Asp Ala Tyr Leu Ile His Thr Pro Tyr Trp Ala Asp Ser Thr His Gln 
        115                 120                 125             


Leu Gln Lys Ala Trp Lys Gly Met Glu Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140                 


Ala Arg Thr Ile Gly Val Ser Asn Phe Gly Ser Thr His Leu Arg Thr 
145                 150                 155                 160 


Val Leu Ala Thr Ala Gln Ser Thr Pro Ser Val Asn Gln Leu Glu Phe 
                165                 170                 175     


His Pro Tyr Leu Asn Pro Arg Asp Gly Asn Asp Tyr Leu Phe Ser Leu 
            180                 185                 190         


Arg Asp Asn Met Arg Asp Ile Thr Ile Ser Ala Tyr Gly Ala Leu Ala 
        195                 200                 205             


Pro Ile Pro Arg Lys Tyr Pro Asp Pro Leu Ala Glu Asn Leu Lys Glu 
    210                 215                 220                 


Val Ala Asn Arg Lys Gly Val Gly Thr Asp Leu Val Cys Leu Arg Trp 
225                 230                 235                 240 


Cys Ile Glu Gln Gly Ile Ala Thr Ile Thr Thr Ser Arg His Glu Asp 
                245                 250                 255     


Arg Met Lys Gly Tyr Leu Arg Val Phe Asp Phe Gln Ile Thr Pro Asp 
            260                 265                 270         


Glu Val Met Ala Ile Gly Ala Ser Ala Lys Ser Cys Leu Gly Asp Lys 
        275                 280                 285             


Glu Gln Pro Leu Thr Arg Ile Glu Lys Tyr His Met Ala Gln Lys His 
    290                 295                 300                 


Thr 
305 


<210>  166
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 161

<400>  166

Met Ser His Lys Leu Ser Leu Asn Asp Gly Val Ser Met Pro Thr Leu 
1               5                   10                  15      


Ala Phe Gly Val Gly Gly Ala Phe Gln Lys Arg Ser Gly Ser Asp Ala 
            20                  25                  30          


Asp His Arg Pro Thr Val Asp Ala Val Leu Glu Ala Leu Arg Val Gly 
        35                  40                  45              


Tyr Arg His Leu Asp Thr Ala Glu Met Tyr Asn Thr Glu Leu Glu Val 
    50                  55                  60                  


Gly Ala Ala Ile His Asp Ser Ile Ala Glu Gly Ile Val Gln Pro Arg 
65                  70                  75                  80  


Asp Glu Leu Phe Ile Thr Thr Lys Val Ser Ser Asp Arg Leu Asn Ile 
                85                  90                  95      


Leu Glu Ser Ile Asp Val Ser Leu Gln Lys Leu Lys Leu Asp Tyr Val 
            100                 105                 110         


Asp Ala Tyr Leu Ile His Asn Pro Tyr Trp Val Val Ser Asp Tyr Asp 
        115                 120                 125             


Leu Gln Lys Ala Trp Lys Gly Met Glu Glu Val Lys Ala Ser Gly Lys 
    130                 135                 140                 


Ala Arg Thr Ile Gly Val Ser Asn Phe Gln Ser Lys Met Leu Arg Gln 
145                 150                 155                 160 


Val Leu Ala Thr Ala Gln Thr Pro Pro Arg Val Asn Gln Phe Glu Phe 
                165                 170                 175     


His Pro Tyr Asn Ser Val Gln Asp Gly Asn Asp Tyr Leu Tyr Ser Leu 
            180                 185                 190         


Lys Asp Asn Met Arg Asp Ile Thr Ile Ser Ala Tyr Gly Ala Leu Ala 
        195                 200                 205             


Pro Ile Thr Arg Ala Ile Pro Asp Gln Leu Asp Glu Thr Leu Lys Glu 
    210                 215                 220                 


Val Ala Asp Arg Tyr Gly Val Gly Thr Asp Leu Val Cys Leu Arg Trp 
225                 230                 235                 240 


Cys Ile Glu Gln Gly Val Ala Thr Ile Thr Thr Ser Arg His Glu Asp 
                245                 250                 255     


Arg Met Lys Gly Tyr Leu Arg Val Phe Asp Phe Gln Ile Thr Pro Asp 
            260                 265                 270         


Glu Val Met Gln Ile Gly Ala Ser Asn Gln Ala Tyr Leu Gly Asp Lys 
        275                 280                 285             


Glu Ala Pro Leu Val Arg Ile Glu Lys Tyr His Met Ala Gln Lys His 
    290                 295                 300                 


Thr 
305 


<210>  167
<211>  1923
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  167
atgagcagct ataaattccc cgtcgacctc aagcagttca agcagctcaa gcttgaccca       60

aaaagcccac agctttctgc tcagcagaag aacgacctcc tgcataacat caacattttc      120

agagatgcaa tcatcgcatt cacggccacg ggtgccgccc gtggactcgc gggccacact      180

gggggtccgt tcgacactgc cccagaggtc tgcatcttgc tcgccttcat gaacgcgaac      240

cccgatggtt tcgttgatgc cctgtacgac gaagctggcc atcgggttgc cacgcaatac      300

ttgcttgctg cgctggacgg aaagattgac cccgaccacc tgctgaacta ccgcgctgcc      360

gattcgaaac tcccgggcca ccctgagctt ggcctgacgc cgggcatcaa gttcagctcg      420

ggtcgtcttg gtcacatgtg ggccatgtgc aacggtatct ccatggccca caaggataag      480

aacgtcctgc tgctgggatc ggatggctcc cagcaggaag gaaacgacgc cgaggccgcg      540

cgcattgccg ttgccaaaaa cctgaaggtg aagctgttca tcgacaacaa cgacgtcaca      600

atcgccggac atccttcgat atacttgaag ggctacgaga tcgctcgtac gctcgagggg      660

cacggcttga aggtcatccg cgcccagggt gagaatctgg attcgcttta cggggcgatg      720

tgtgaaatca tcaactacaa cggccctgcc gctgttgtgg tagaccggaa gatggccgca      780

ggcatcgaag aaattgaggg agagacccac gctcacgatg tcattccggt cgatatcgct      840

cgcaaatacc ttaccaagcg tggatacagc aaggagcagc ttgctttcta cgaccagatc      900

aagcctggat cgaacccgca ccagtaccag ggctcaacca aggagaaggg tgcgaaccgt      960

gcgatttttg gtgaagccgt gaactccgtg ctcgacggcc tcagcaagga agagcgtgtc     1020

cgtcgggtca tggtcatcga ttctgacctt gcgggctcta ccggcctgaa ggcaattcaa     1080

tcgaagcacc ccgaggtgtt cgttgcatcc ggtgtcatgg agcggggcaa cttctccgcc     1140

gctgctggct tcggattcgg cagcaacggc gagcgtcagg gtgttttctc tactttctcg     1200

gctttcctgg agatgtgcgt ctcggaaatt accatggcac gcttgaatcg ctgcaccgtc     1260

ctctcccact tctcccacag cggtgttgat gagatggccg acaacacctg ccactttggt     1320

ctgaatctct tctttgcaga caacggcctg atggatgccg agagcacatc gttgtacttc     1380

cccgccgacg gtgagcagat gaaggcggtc gtcaacaagg tcttttggga taagagcatg     1440

cgtttcatct tctcaacgcg ttccaaggtt ccttacatcc tcaaagaagg taccgaccag     1500

aagctctatg gcgacggcta cgagtttgtc ccgggcaagg aagaagtcat ccgcaagggt     1560

tccgccggct atgttgtctc gtacggtgat atgctctacc gctcgctcga tgccgttgag     1620

cgcctgcgca aggagggcct tgatgttggc ctcatcaata agcccacact gaatattgtc     1680

gatgaggaca ccatcaaggt ttacggatcg actccgttcg ttgtggtcgt cgagtcaatt     1740

gctcagaaga cgggtcttgg ctcccgcctg ggcagtcacc ttcttgagcg caagcttacg     1800

cccaagttca aggcgattgg tgccgtgagg gagggctctg gcggcttgta cgagcagatt     1860

aatgcccagg gtcttggacc aaacgacatc attgcggcag tgaaggaggt cagtgggaaa     1920

taa                                                                   1923


<210>  168
<211>  640
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  168

Met Ser Ser Tyr Lys Phe Pro Val Asp Leu Lys Gln Phe Lys Gln Leu 
1               5                   10                  15      


Lys Leu Asp Pro Lys Ser Pro Gln Leu Ser Ala Gln Gln Lys Asn Asp 
            20                  25                  30          


Leu Leu His Asn Ile Asn Ile Phe Arg Asp Ala Ile Ile Ala Phe Thr 
        35                  40                  45              


Ala Thr Gly Ala Ala Arg Gly Leu Ala Gly His Thr Gly Gly Pro Phe 
    50                  55                  60                  


Asp Thr Ala Pro Glu Val Cys Ile Leu Leu Ala Phe Met Asn Ala Asn 
65                  70                  75                  80  


Pro Asp Gly Phe Val Asp Ala Leu Tyr Asp Glu Ala Gly His Arg Val 
                85                  90                  95      


Ala Thr Gln Tyr Leu Leu Ala Ala Leu Asp Gly Lys Ile Asp Pro Asp 
            100                 105                 110         


His Leu Leu Asn Tyr Arg Ala Ala Asp Ser Lys Leu Pro Gly His Pro 
        115                 120                 125             


Glu Leu Gly Leu Thr Pro Gly Ile Lys Phe Ser Ser Gly Arg Leu Gly 
    130                 135                 140                 


His Met Trp Ala Met Cys Asn Gly Ile Ser Met Ala His Lys Asp Lys 
145                 150                 155                 160 


Asn Val Leu Leu Leu Gly Ser Asp Gly Ser Gln Gln Glu Gly Asn Asp 
                165                 170                 175     


Ala Glu Ala Ala Arg Ile Ala Val Ala Lys Asn Leu Lys Val Lys Leu 
            180                 185                 190         


Phe Ile Asp Asn Asn Asp Val Thr Ile Ala Gly His Pro Ser Ile Tyr 
        195                 200                 205             


Leu Lys Gly Tyr Glu Ile Ala Arg Thr Leu Glu Gly His Gly Leu Lys 
    210                 215                 220                 


Val Ile Arg Ala Gln Gly Glu Asn Leu Asp Ser Leu Tyr Gly Ala Met 
225                 230                 235                 240 


Cys Glu Ile Ile Asn Tyr Asn Gly Pro Ala Ala Val Val Val Asp Arg 
                245                 250                 255     


Lys Met Ala Ala Gly Ile Glu Glu Ile Glu Gly Glu Thr His Ala His 
            260                 265                 270         


Asp Val Ile Pro Val Asp Ile Ala Arg Lys Tyr Leu Thr Lys Arg Gly 
        275                 280                 285             


Tyr Ser Lys Glu Gln Leu Ala Phe Tyr Asp Gln Ile Lys Pro Gly Ser 
    290                 295                 300                 


Asn Pro His Gln Tyr Gln Gly Ser Thr Lys Glu Lys Gly Ala Asn Arg 
305                 310                 315                 320 


Ala Ile Phe Gly Glu Ala Val Asn Ser Val Leu Asp Gly Leu Ser Lys 
                325                 330                 335     


Glu Glu Arg Val Arg Arg Val Met Val Ile Asp Ser Asp Leu Ala Gly 
            340                 345                 350         


Ser Thr Gly Leu Lys Ala Ile Gln Ser Lys His Pro Glu Val Phe Val 
        355                 360                 365             


Ala Ser Gly Val Met Glu Arg Gly Asn Phe Ser Ala Ala Ala Gly Phe 
    370                 375                 380                 


Gly Phe Gly Ser Asn Gly Glu Arg Gln Gly Val Phe Ser Thr Phe Ser 
385                 390                 395                 400 


Ala Phe Leu Glu Met Cys Val Ser Glu Ile Thr Met Ala Arg Leu Asn 
                405                 410                 415     


Arg Cys Thr Val Leu Ser His Phe Ser His Ser Gly Val Asp Glu Met 
            420                 425                 430         


Ala Asp Asn Thr Cys His Phe Gly Leu Asn Leu Phe Phe Ala Asp Asn 
        435                 440                 445             


Gly Leu Met Asp Ala Glu Ser Thr Ser Leu Tyr Phe Pro Ala Asp Gly 
    450                 455                 460                 


Glu Gln Met Lys Ala Val Val Asn Lys Val Phe Trp Asp Lys Ser Met 
465                 470                 475                 480 


Arg Phe Ile Phe Ser Thr Arg Ser Lys Val Pro Tyr Ile Leu Lys Glu 
                485                 490                 495     


Gly Thr Asp Gln Lys Leu Tyr Gly Asp Gly Tyr Glu Phe Val Pro Gly 
            500                 505                 510         


Lys Glu Glu Val Ile Arg Lys Gly Ser Ala Gly Tyr Val Val Ser Tyr 
        515                 520                 525             


Gly Asp Met Leu Tyr Arg Ser Leu Asp Ala Val Glu Arg Leu Arg Lys 
    530                 535                 540                 


Glu Gly Leu Asp Val Gly Leu Ile Asn Lys Pro Thr Leu Asn Ile Val 
545                 550                 555                 560 


Asp Glu Asp Thr Ile Lys Val Tyr Gly Ser Thr Pro Phe Val Val Val 
                565                 570                 575     


Val Glu Ser Ile Ala Gln Lys Thr Gly Leu Gly Ser Arg Leu Gly Ser 
            580                 585                 590         


His Leu Leu Glu Arg Lys Leu Thr Pro Lys Phe Lys Ala Ile Gly Ala 
        595                 600                 605             


Val Arg Glu Gly Ser Gly Gly Leu Tyr Glu Gln Ile Asn Ala Gln Gly 
    610                 615                 620                 


Leu Gly Pro Asn Asp Ile Ile Ala Ala Val Lys Glu Val Ser Gly Lys 
625                 630                 635                 640 


<210>  169
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 168

<400>  169

Met Ser Ser Tyr Lys Phe Pro Val Asp Leu Lys Gln Phe Lys Gln Leu 
1               5                   10                  15      


Lys Leu Asp Pro Lys Ser Pro Gln Leu Ser Ala Gln Gln Lys Asn Asp 
            20                  25                  30          


Leu Leu His Asn Ile Asn Ile Phe Arg Asp Ala Ile Ile His Phe Thr 
        35                  40                  45              


Ala Thr Gly Ala Ala Arg Gly Leu Ala Gly His Thr Gly Gly Pro Phe 
    50                  55                  60                  


Asp Thr Ala Pro Glu Val Cys Ile Leu Leu Ala Phe Met Asn Val Asn 
65                  70                  75                  80  


Pro Asp Lys Phe Val Asp Ala Leu Tyr Asp Glu Ala Gly His Arg Val 
                85                  90                  95      


Ala Thr Gln Tyr Leu Leu Ala Ala Leu Asp Gly Lys Ile Asp Pro Asp 
            100                 105                 110         


His Leu Leu Asn Tyr Arg Ala Ala Asp Ser Lys Leu Pro Gly His Pro 
        115                 120                 125             


Glu Leu Gly Leu Thr Pro Gly Ile Lys Phe Ser Ser Gly Arg Leu Gly 
    130                 135                 140                 


His Met Trp Ala Met Cys Asn Gly Ile Ser Met Ala Arg Lys Asp Lys 
145                 150                 155                 160 


Asn Val Leu Leu Leu Gly Ser Asp Gly Ser Gln Gln Glu Gly Asn Asp 
                165                 170                 175     


Ala Glu Ala Ala Arg Ile Ala Val Ala Lys Asn Leu Lys Val Lys Leu 
            180                 185                 190         


Phe Ile Asp Asn Asn Asp Val Thr Ile Ala Gly His Pro Ser Ala Tyr 
        195                 200                 205             


Leu Lys Gly Tyr Glu Ile Ala Met Thr Leu Glu Gly His Gly Leu Lys 
    210                 215                 220                 


Val Ile Arg Ala Gln Gly Glu Asn Leu Asp Ser Leu Asp Ala Ala Met 
225                 230                 235                 240 


Cys Glu Ile Ile Asn Tyr Asn Gly Pro Ala Ala Val Val Val Asp Arg 
                245                 250                 255     


Lys Met Ala Ala Gly Ile Glu Glu Ile Glu Gly Glu Thr Pro Ser His 
            260                 265                 270         


Asp Ala Ile Pro Val Ser Ile Ala Arg Lys Tyr Leu Thr Lys Arg Gly 
        275                 280                 285             


Tyr Glu Ala Glu Leu Leu Ala Trp Tyr Asp Gln Ile Lys Pro Gly Lys 
    290                 295                 300                 


Asn Pro Ala Gln Tyr Gln Gly Ser Thr Lys Glu Lys Gly Ala Asn Arg 
305                 310                 315                 320 


Ala Ile Phe Gly Glu Ala Val Asn Ser Val Leu Asp Gly Leu Ser Lys 
                325                 330                 335     


Glu Glu Arg Val Arg Arg Val Met Val Ile Asp Ser Asp Leu Ala Gly 
            340                 345                 350         


Ser Thr Gly Leu Lys Asp Ile Gln Ser Lys His Pro Glu Val Phe Val 
        355                 360                 365             


Ala Ser Gly Val Met Glu Arg Gly Asn Phe Ser Ala Ala Ala Gly Phe 
    370                 375                 380                 


Gly Phe Gly Ser Asn Gly Glu Arg Gln Gly Val Phe Ser Thr Phe Ser 
385                 390                 395                 400 


Ala Phe Leu Glu Met Cys Val Ser Glu Ile Thr Met Ala Arg Leu Asn 
                405                 410                 415     


Arg Cys Thr Val Leu Ser His Phe Ser His Ser Gly Val Asp Glu Met 
            420                 425                 430         


Ala Asp Asn Thr Cys His Phe Gly Leu Asn Leu Phe Phe Ala Asp Asn 
        435                 440                 445             


Gly Leu Met Asp Ala Glu Ser Thr Ser Leu Tyr Phe Pro Ala Asp Gly 
    450                 455                 460                 


Glu Gln Met Ala Ala Val Val Asn Lys Val Phe Trp Asp Gln Ser Met 
465                 470                 475                 480 


Arg Phe Ile Phe Ser Thr Arg Ser Lys Val Pro Tyr Ile Leu Lys Ala 
                485                 490                 495     


Gly Thr Asp Gln Lys Leu Tyr Gly Asp Gly Tyr Glu Phe Val Gln Gly 
            500                 505                 510         


Lys Glu Glu Val Ile Arg Lys Gly Thr Ala Gly Tyr Val Val Ser Tyr 
        515                 520                 525             


Gly Asp Met Leu Tyr Arg Ser Leu Asp Ala Val Glu Met Leu Arg Lys 
    530                 535                 540                 


Glu Gly Leu Asp Val Gly Leu Ile Asn Lys Pro Thr Leu Asn Ile Val 
545                 550                 555                 560 


Asp Glu Asp Thr Ile Ile Val Tyr Gly Ser Thr Pro Phe Val Val Val 
                565                 570                 575     


Val Glu Ser Ile Asn Gln Lys Thr Gly Leu Gly Ser Arg Leu Gly Ser 
            580                 585                 590         


His Leu Leu Glu Lys Gly Leu Glu Pro Lys Phe Lys Arg Ile Gly Leu 
        595                 600                 605             


Val Arg Glu Gly Ser Gly Gly Leu Tyr Glu Gln Ile Asn Ala Gln Gly 
    610                 615                 620                 


Leu Gly Pro Asn Asp Ile Ile Ala Ala Val Lys Glu Val Ser Gly Lys 
625                 630                 635                 640 


<210>  170
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 168

<400>  170

Met Ser Ser Tyr Lys Phe Pro Val Asp Leu Lys Gln Phe Lys Gln Leu 
1               5                   10                  15      


Lys Leu Asp Pro Lys Ser Pro Gln Leu Ser Ala Gln Gln Lys Asn Asp 
            20                  25                  30          


Leu Leu Arg Asn Ile Asn Ile Phe Arg Asp Ala Ile Ile Ala Phe Thr 
        35                  40                  45              


Ala Thr Gly Ala Ala Arg Gly Leu Ala Gly His Thr Gly Gly Pro Phe 
    50                  55                  60                  


Asp Thr Ala Pro Glu Val Cys Ile Leu Leu Ala Phe Met Asn Ala Asn 
65                  70                  75                  80  


Pro Asp Gly Pro Val Asp Ala Leu Tyr Asp Glu Ala Gly His Arg Val 
                85                  90                  95      


Ala Thr Gln Tyr Leu Leu Ala Ala Leu Asp Gly Lys Ile Asp Pro Asp 
            100                 105                 110         


His Leu Asp Asn Tyr Arg Ala Ala Asp Ser Lys Leu Pro Gly His Pro 
        115                 120                 125             


Glu Leu Gly Leu Thr Pro Gly Ile Asp Phe Ser Ser Gly Arg Leu Gly 
    130                 135                 140                 


His Met Trp Ala Met Cys Asn Gly Ile Ser Met Ala His Lys Asp Lys 
145                 150                 155                 160 


Asn Val Leu Leu Leu Gly Ser Asp Gly Ser Gln Gln Glu Gly Asn Asp 
                165                 170                 175     


Ala Glu Ala Ala Arg Ile Ala Val Ala Lys Asn Leu Lys Val Lys Leu 
            180                 185                 190         


Phe Ile Asp Asn Asn Gln Val Thr Ile Ala Gly His Pro Ser Ile Tyr 
        195                 200                 205             


Leu Lys Leu Phe Glu Ile Ala Arg Thr Leu Glu Gly His Gly Leu Lys 
    210                 215                 220                 


Val Ile Arg Ala Gln Gly Glu Asn Leu Asp Ser Leu Phe Gly Ala Met 
225                 230                 235                 240 


Cys His Ile Ile Asn Tyr Asn Gly Pro Ala Ala Val Val Val Asp Arg 
                245                 250                 255     


Lys Met Ala Ala Gly Ile Glu Glu Ile Glu Gly Glu Thr His Gly His 
            260                 265                 270         


Asp Val Lys Pro Val Asp Ile Ala Leu Lys Tyr Leu Thr Lys Gln Gly 
        275                 280                 285             


Tyr Ser Lys Leu Gln Leu Ala Phe Tyr Asp Gln Ile Lys Pro Gly Ser 
    290                 295                 300                 


Asn Pro Ser Gln Tyr Gln Gly Ser Thr Lys Glu Lys Gly Ala Asn Arg 
305                 310                 315                 320 


Ala Ile Phe Gly Glu Ala Val Asn Ser Val Leu Asp Gly Leu Ser Lys 
                325                 330                 335     


Glu Glu Arg Val Arg Arg Val Met Val Ile Asp Ser Asp Leu Ala Gly 
            340                 345                 350         


Ser Thr Gly Leu Lys Ala Ile Ser Ser Lys His Pro Glu Val Phe Val 
        355                 360                 365             


Ala Ser Gly Val Met Glu Arg Gly Asn Phe Ser Val Ala Ala Gly Phe 
    370                 375                 380                 


Gly Phe Gly Ser Asn Gly Glu Ile Gln Gly Val Phe Ser Thr Phe Ser 
385                 390                 395                 400 


Ala Phe Leu Asp Met Cys Val Ser Glu Ile Thr Met Ala Arg Leu Asn 
                405                 410                 415     


Lys Cys Thr Val Leu Ser His Phe Ser His Ser Gly Val Asp Gly Met 
            420                 425                 430         


Ala Asp Asn Thr Cys His Phe Gly Leu Asn Leu Phe Phe Ala Asp Asn 
        435                 440                 445             


Gly Leu Met Asp Ala Glu Ser Thr Ser Leu Tyr Phe Pro Ala Asp Gly 
    450                 455                 460                 


Glu Gln Met Lys Gly Val Val Lys Lys Val Phe Asp Cys Lys Ser Met 
465                 470                 475                 480 


Arg Phe Ile Phe Ser Thr Arg Ser Lys Val Pro Tyr Ile Leu Lys Ile 
                485                 490                 495     


Gly Glu Asp Gln Lys Leu Tyr Gly Asp Gly Tyr Glu Phe Val Pro Gly 
            500                 505                 510         


Lys Glu Glu Val Ile Arg Lys Gly Ser Ala Gly Tyr Val Val Ser Tyr 
        515                 520                 525             


Gly Asp Met Leu Tyr Arg Ser Leu Asp Ala Val Glu Arg Leu Arg Lys 
    530                 535                 540                 


Glu Gly Leu Asp Val Gly Leu Ile Asn Lys Pro Thr Leu Asn Ile Val 
545                 550                 555                 560 


Asp Glu Asp Thr Ile Lys Val Tyr Gly Ser Thr Pro Phe Val Val Val 
                565                 570                 575     


Val Glu Ser Ile Ala Ala Lys Thr Gly Leu Gly Ser Arg Leu Gly Ser 
            580                 585                 590         


His Leu Ala Glu Arg Lys Leu Thr Pro Lys Phe Lys Ala Ile Gly Ala 
        595                 600                 605             


Val His Glu Gly Ser Gly Gly Leu Lys Glu Gln Ile Asn Ala Gln Gly 
    610                 615                 620                 


Leu Gly Pro Asn Asp Ile Ile Ala Ala Val Lys Glu Thr Ser Gly Lys 
625                 630                 635                 640 


<210>  171
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 168

<400>  171

Met Ser Ser Tyr Lys Phe Pro Val Asp Leu Lys Gln Phe Lys Gln Leu 
1               5                   10                  15      


Lys Leu Asp Pro Lys Ser Pro Gln Leu Ser Ala Gln Gln Lys Lys Asp 
            20                  25                  30          


Leu Leu His Asn Ile Asn Ile Phe Arg Asp Ile Ile Ile Ala Phe Thr 
        35                  40                  45              


Ala Thr Gly Ala Ala Arg Gly Leu Ala Gly His Thr Gly Gly Pro Phe 
    50                  55                  60                  


Asp Thr Ala Pro Glu Val Cys Ile Leu Leu Ala Phe Met Asn Ala Asn 
65                  70                  75                  80  


Pro Asp Gly Phe Val Asp Ala Leu Tyr Asp Glu Ala Gly His Arg Val 
                85                  90                  95      


Ala Thr Gln Tyr Leu Leu Ala Ala Leu Asp Gly Lys Ile Asp Pro Asp 
            100                 105                 110         


His Leu Arg Asn Tyr Arg Ala Ala Asp Ser Lys Leu Pro Gly His Pro 
        115                 120                 125             


Glu Leu Gly Leu Thr Pro Gly Ile Lys Phe Ser Ser Gly Arg Leu Gly 
    130                 135                 140                 


His Met Trp Ala Met Cys Asn Gly Ile Ser Met Ala His Lys Asp Arg 
145                 150                 155                 160 


Asn Val Leu Leu Leu Gly Ser Asp Gly Ser Gln Gln Glu Gly Asn Asp 
                165                 170                 175     


Ala Glu Ala Ala Arg Ile Ala Val Ala Lys Asn Leu Lys Val Lys Leu 
            180                 185                 190         


Phe Ile Asp Asn Asn Leu Val Thr Ile Ala Gly His Pro Ser Asp Tyr 
        195                 200                 205             


Met Lys Gly Tyr Glu Ile Ala Arg Thr Leu Glu Gly His Gly Leu Lys 
    210                 215                 220                 


Val Ile Arg Ala Gln Gly Glu Asn Leu Asp Ser Leu Tyr Gly Ala Met 
225                 230                 235                 240 


Cys Gln Ile Ile Ile Tyr Asn Gly Pro Ala Ala Val Val Val Arg Arg 
                245                 250                 255     


Ile Met Ala Ala Gly Ile Glu Glu Ile Glu Gly Glu Thr Phe Ala His 
            260                 265                 270         


Asp Val Ile Pro Ser Asp Glu Glu Arg Lys Tyr Leu Val Glu Lys Gly 
        275                 280                 285             


Glu Ser Lys Glu Ile Leu Ala Phe Glu Asp Gln Ile Lys Thr Gly Ser 
    290                 295                 300                 


Leu Pro His Gln Tyr Gln Gly Ser Thr Lys Glu Ala Gly Ala Asn Arg 
305                 310                 315                 320 


Ala Ile Phe Gly Glu Ala Val Asn Ser Val Leu Asp Gly Leu Ser Asn 
                325                 330                 335     


Glu Glu Arg Val Arg Arg Val Met Val Ile Asp Ser Asp Leu Ala Asn 
            340                 345                 350         


Ser Thr Gly Leu Lys Ala Ile His Ser Lys His Pro Glu Val Phe Val 
        355                 360                 365             


Ala Ser Gly Val Met Glu Arg Gly Asn Phe Ser Ala Ala Ala Gly Phe 
    370                 375                 380                 


Gly Ala Gly Ser Asn Gly Glu Leu Gln Gly Val Phe Ser Thr Phe Ser 
385                 390                 395                 400 


Gly Phe Leu Glu Met Cys Val Ser Glu Ile Thr Met Ala Arg Leu Asn 
                405                 410                 415     


Arg Cys Thr Val Leu Ser His Phe Ser His Ser Gly Val Asp Glu Met 
            420                 425                 430         


Thr Asp Asn Thr Cys His Phe Gly Leu Asn Leu Phe Phe Ala Asp Asn 
        435                 440                 445             


Ser Leu Met Asp Ala Glu Ser Thr Ser Leu Tyr Phe Pro Ala Asp Gly 
    450                 455                 460                 


Glu Gln Met Lys Ala Val Val Glu Lys Val Phe Trp Leu Lys Ser Met 
465                 470                 475                 480 


Arg Phe Ile Phe Ser Thr Arg Ser Lys Val Pro Tyr Ile Leu Lys Glu 
                485                 490                 495     


Gly Thr Asp Gln Ala Leu Trp Gly Asp Asp Tyr Glu Phe Val Pro Gly 
            500                 505                 510         


Lys Glu Ile Val Ile Arg Lys Gly Ser Ala Gly Tyr Val Val Ser Ser 
        515                 520                 525             


Gly Asp Met Leu Tyr Arg Ser Leu Asp Ala Val Glu Arg Leu Arg Lys 
    530                 535                 540                 


Glu Gly Leu Lys Val Gly Leu Ile Asn Lys Pro Thr Leu Asn Ile Val 
545                 550                 555                 560 


Asp Glu Asp Thr Ile Val Val Tyr Gly Ser Thr Pro Phe Val Val Val 
                565                 570                 575     


Val Glu Ser Ile Ala Gln Arg Thr Gly Leu Gly Ser Arg Leu Gly Ser 
            580                 585                 590         


Trp Leu Leu Glu Arg Lys Leu Thr Pro Lys Phe Lys Ala Ile Gly Ala 
        595                 600                 605             


Val Arg Glu Gly Ser Gly Gly Leu Tyr Glu Gln Ile Asn Ala Gln Gly 
    610                 615                 620                 


Leu Gly Pro Asn Asn Ile Ile Ala Ala Val Leu Glu Val Ser Gly Lys 
625                 630                 635                 640 


<210>  172
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 168

<400>  172

Met Ser Ser Tyr Lys Phe Pro Val Asp Leu Lys Gln Phe Lys Gln Leu 
1               5                   10                  15      


Lys Leu Asp Pro Lys Ser Pro Gln Leu Ser Ala Gln Gln Lys Asn Asp 
            20                  25                  30          


Leu Leu His Asn Ile Asn Ile Phe Arg Asp Phe Ile Ile Met Phe Thr 
        35                  40                  45              


Met Thr Gly Ala Ala Arg Gly Leu Ala Gly His Thr Gly Gly Pro Phe 
    50                  55                  60                  


Asp Thr Ala Pro Glu Val Cys Ile Leu Leu Ala Phe Met Asn Ala Asn 
65                  70                  75                  80  


Pro Asp Gly Phe Val Asp Ala Leu Tyr Asp Glu Ala Gly His Arg Val 
                85                  90                  95      


Ala Thr Gln Tyr Leu Leu Ala Ala Leu Asp Gly Lys Ile Asp Phe Asp 
            100                 105                 110         


His Leu Trp Asn Tyr Arg Ala Ala Asp Ser Thr Leu Pro Gly His Pro 
        115                 120                 125             


Glu Leu His Leu Thr Pro Gly Ile Lys Phe Ser Ser Gly Arg Leu Gly 
    130                 135                 140                 


His Met Trp Ala Tyr Cys Asn Gly Ile Ser Met Ala Lys Lys Asp Lys 
145                 150                 155                 160 


Asn Val Leu Leu Leu Gly Ser Asp Gly Ser Gln Gln Glu Gly Leu Asp 
                165                 170                 175     


Ala Glu Ala Ala Arg Ile Ala Val His Leu Asn Leu Lys Val Lys Leu 
            180                 185                 190         


Phe Ile Asp Asn Asn Asp Val Thr Ile Ala Gly Ala Pro Ser Ile Tyr 
        195                 200                 205             


Asn Ala Gly Tyr Glu Ile Ser Arg Thr Leu Glu Gly His Gly Leu Glu 
    210                 215                 220                 


Val Ile Ala Ala Gln Gly Glu Asn Leu Asp Ser Leu Tyr Gly Ala Met 
225                 230                 235                 240 


Cys Glu Ile Ile Asn Tyr Asn Gly Pro Ala Ala Val Val Val Asp Arg 
                245                 250                 255     


Lys Met Ala Ala Gly Ile Glu Glu Ile Glu Gly Gln Gly His Ala His 
            260                 265                 270         


Asp Lys Ala Pro Val Asp Ile Asn Arg Lys Tyr Leu Thr Lys Arg Gly 
        275                 280                 285             


Tyr Ser Lys Glu Gln Leu Ala Tyr Tyr Glu Gln Ile Pro Gln Gly Ser 
    290                 295                 300                 


Ile Pro Glu Gln Tyr Gln Ala Ser Pro Lys Leu Lys Gly Ala Asn Arg 
305                 310                 315                 320 


Ser Ile Phe Gly Asn Ala Val Asn Ser Val Leu Ala Gly Leu Ser Asp 
                325                 330                 335     


Glu Ala Arg Val Arg Arg Val Met Val Ile Asp Ser Asp Leu Ala Gly 
            340                 345                 350         


Ser Thr Gly Leu Lys Tyr Ile Gln Ser Lys His Pro Glu Val Phe Val 
        355                 360                 365             


Ala Ser Gly Val Met Glu Arg Gly Asn Phe Ser Ala Ala Ala Gly Phe 
    370                 375                 380                 


Gly Phe Gly Ser Asn Gly Glu Arg Gln Gly Val Phe Ile Thr Phe Ser 
385                 390                 395                 400 


Ala Phe Leu Glu Met Cys Val Ser Glu Ile Thr His Ala Arg Leu Met 
                405                 410                 415     


Arg Cys Thr Val Leu Ser His Phe Ser His Ser Gly Val Asp Val Met 
            420                 425                 430         


Ala Asp Asn Thr Cys His Phe Gly Leu Asn Leu Phe Phe Ala Asp Asn 
        435                 440                 445             


Tyr Leu Met Asp Ala Glu Ser Thr Ser Leu Tyr Phe Pro Ala Asp Gly 
    450                 455                 460                 


Tyr Gln Met Arg Ala Val Val Asn Lys Val Phe His Asp Lys Ser Met 
465                 470                 475                 480 


Arg Phe Ile Phe Ser Thr Arg Ser Lys Val Pro Tyr Ile Leu Lys Asp 
                485                 490                 495     


Lys Glu Asp Gly Lys Leu Tyr Glu Asp Gly Tyr Glu Phe Val Pro Gly 
            500                 505                 510         


Lys Glu Glu Val Ile Arg Lys Gly Ser Ala Gly Tyr Val Val Ser Tyr 
        515                 520                 525             


Gly Ala Met Leu Lys Arg Ser Leu Asp Ala Val Glu Arg Leu Arg Lys 
    530                 535                 540                 


Glu Gly Leu Asp Val Gly Leu Ile Asn Lys Pro Thr Leu Asn Ile Val 
545                 550                 555                 560 


Asp Glu Asp Thr Ile Lys Val Tyr Gly Ser Thr Pro Phe Val Val Val 
                565                 570                 575     


Val Glu Ser Ile Ala Leu Lys Thr Gly Leu Gly Ser Arg Leu Gly Ser 
            580                 585                 590         


His Leu Leu Glu Ser Lys Leu Asn Pro Lys Phe Asp Ala Ile Gly Ile 
        595                 600                 605             


Val Arg Glu Gly Lys Gly Gly Leu Gly Glu Gln Ile Asn Ala Gln Gly 
    610                 615                 620                 


Leu Gly Pro Asn Asp Ile Ile Glu Ala Val Arg Lys Leu Ser Gly Lys 
625                 630                 635                 640 


<210>  173
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 168

<400>  173

Met Ser Ser Tyr Lys Phe Pro Val Asp Leu Lys Gln Phe Lys Gln Leu 
1               5                   10                  15      


Lys Leu Asp Pro Lys Ser Pro Gln Leu Ser Glu Gln Gln Lys Asn Asp 
            20                  25                  30          


Leu Leu His Asn Ile Asn Ile Phe Arg Asp Ala Ile Ile Ala Phe Thr 
        35                  40                  45              


Ala Thr Gly Ala Ala Arg Gly Leu Ala Gly His Thr Gly Gly Pro Phe 
    50                  55                  60                  


Asp Thr Ala Pro Glu Val Cys Ile Leu Leu Ala Phe Met Asn Ala Asn 
65                  70                  75                  80  


Pro Asp Gly Phe Val Asp Ala Leu Tyr Asp Glu Ala Gly His Arg Val 
                85                  90                  95      


Ala Thr Gln Tyr Leu Leu Ala Ala Leu Asp Gly Lys Ile Asp Glu Asp 
            100                 105                 110         


His Leu Leu Asn Tyr Arg Ala Ala Asp Ser Lys Leu Pro Gly His Pro 
        115                 120                 125             


Glu Leu Glu Leu Thr Pro Gly Ile Asp Phe Ser Ser Gly Arg Leu Gly 
    130                 135                 140                 


His Met Trp Ala Leu Cys Asn Gly Ile Ser Met Ala Leu Lys Asp Trp 
145                 150                 155                 160 


Asn Val Leu Leu Leu Gly Ser Asp Gly Ser Gln Gln Glu Gly Asn Asp 
                165                 170                 175     


Ala Glu Ala Ala Arg Ile Ala Val Pro Lys Asn Leu Lys Val Lys Leu 
            180                 185                 190         


Phe Ile Asp Asn Asn Asp Val Thr Ile Ala Gly Pro Pro Ser Asp Tyr 
        195                 200                 205             


Met Lys Pro Asn Asp Ile Ala Asp Thr Leu Glu Gly His Gly Leu Glu 
    210                 215                 220                 


Val Ile Phe Ala Gln Gly Glu Asn Leu Asp Ser Leu Val Gly Ala Met 
225                 230                 235                 240 


Cys Arg Ile Ile Glu Tyr Asn Gly Pro Ala Ala Val Val Val Val Arg 
                245                 250                 255     


Lys Met Ala Ala Gly Ile Glu Glu Ile Glu Gly Asp Thr Gly Ala His 
            260                 265                 270         


Asp Val Ile Pro Val Asp Ile Ala Arg Lys Tyr Phe Arg Gly Arg Gly 
        275                 280                 285             


Tyr Ser Lys Arg Ile Leu Ala Phe Tyr Asp Gln Ile Glu Gln Lys Gln 
    290                 295                 300                 


Asn Pro His Gln Tyr Gln Gly Ser Thr Lys Glu Ser Leu Ala Phe Arg 
305                 310                 315                 320 


Ala Ile Phe Gly Glu Ala Val Asn Ser Val Leu Lys Gln Leu Ser Ala 
                325                 330                 335     


Glu Asp Glu Val Arg Arg Val Met Val Ile Asp Ser Asp Leu Ala Gly 
            340                 345                 350         


Ser Thr Gly Leu Lys Ala Ile Leu Glu Lys His Pro Glu Val Phe Val 
        355                 360                 365             


Ala Ser Gly Val Met Glu Arg Gly Asn Phe Ser Ala Ala Ala Gly Phe 
    370                 375                 380                 


Gly Phe Gly Ser Asn Ser Glu Tyr Gln Gly Val Phe Ala Thr Phe Ser 
385                 390                 395                 400 


Val Phe Leu Glu Met Cys Val Ser Glu Ile Thr Met Ala Arg Leu Asn 
                405                 410                 415     


Arg Cys Thr Val Leu Ser His Gly Ser His Ser Gly Val Asp Glu Met 
            420                 425                 430         


Ala Asp Asn Thr Cys His Phe Gly Leu Asn Leu Phe Phe Ala Asp Asn 
        435                 440                 445             


Gly Leu Met Asn Ala Glu Ser Thr Ser Leu Tyr Phe Pro Ala Asp Gly 
    450                 455                 460                 


Val Gln Met Lys Ala Val Val Arg Lys Val Phe Trp Leu Lys Ser Met 
465                 470                 475                 480 


Arg Phe Ile Phe Ser Thr Arg Ser Lys Glu Pro Gln Ile Leu Lys Glu 
                485                 490                 495     


Gly Leu Asp Gln Lys Leu Tyr Gly Asp Gly Tyr Glu Phe Ser Pro Gly 
            500                 505                 510         


Lys Glu Glu Val Ile Arg Lys Gly Asp Ala Gly Tyr Val Val Ser Val 
        515                 520                 525             


Gly Asp Met Leu Tyr Arg Ser Leu Asp Ala Val Glu Ile Leu Arg Lys 
    530                 535                 540                 


Glu Gly Leu Asp Val Gly Leu Ile Asn Lys Pro Thr Leu Asn Ile Val 
545                 550                 555                 560 


Asp Glu Asp Thr Ile Lys Tyr Tyr Glu Ser Thr Pro Phe Val Val Val 
                565                 570                 575     


Val Glu Ser Ile Ala Gln Lys Thr Gly Leu Gly Ser Arg Leu Gly Ser 
            580                 585                 590         


His Leu Asn Glu Arg Lys Gln Thr Pro Lys Phe Lys Ala Ile Gly Gly 
        595                 600                 605             


Val Arg Glu Gly Ser Gly Ala Leu Tyr Glu Gln Ile Asn Ala Gln Gly 
    610                 615                 620                 


Leu Gly Pro Asn Asp Ile Ile Ala Ala Val Lys Glu Val Ser Gly Lys 
625                 630                 635                 640 


<210>  174
<211>  1635
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  174
atggatctgc tgaaagagct ggatgcgccc tctctggcgc cctcgttgtt gggcaccggc       60

gtcgtcctgg tcgtcctgta cttcctcacc gtctccatcc agaaccgaat tcccccgttc      120

gatgcccccg tggtgtctca cgccaaagga ttcctcgcgg ctctgcagga gggcaaagcc      180

aaggtgagtg actttctgtc atcgtggctc gatcatgatg gatgaatcct gacgagactg      240

cagtaccgca atcaaccctt catcctcaac acgccccatc atcctacggt catcctcccc      300

cggaaatggt gggaggagct caagtcgctg cccgagagcc acatctcgtt cgaagccgaa      360

cggctgtatc gctggggcaa gggcaatccg atcgccctcg tcgaccatgt caccatcgag      420

accaccaaga acgagctgac ccgtcacact gcgcgctcct ttcccctgct gctggatgag      480

accgtctacg cggtcgacaa gcacatcggg ccctgcgtgg actggacgcc catcaccgtc      540

tatcccacgg acctgcagct catcgccctg ctgagcagcc gcacctttgt cggcctgccg      600

ctcagtcgca acgagcgctg gctggagatc atgatccgct acaccatcct cagtaaggcc      660

gccgcgcggg ccctgtggcc gtatcccttc ctgctgcggc cgatcctcca gcgctttgcg      720

ccccagtcga aagagttgga gaagcagcgc aaggaggcca gcgccctggt gcgtcccatc      780

ctcgagcagc ggctggccga cctgaagcgc ccggacttca agccccccaa cgacatgatg      840

cagtgggtgc tgcataactg taccccggcg gagcgcgagg atatcgactt cctcgtccag      900

cagcagctca cgctgagcat cgtctcgata cacaccaccg ctcacaacct gacccactgc      960

atcttcgacc tggccgccca tcccgagtgc atcgagccgc tgcgccagga gttcctgccg     1020

ctgctccggg agacgaacgg ccagatcgac aagcagctcc tgaccaagtg caacaagctg     1080

gacagcttct gcaaggaatc ccagcggttc tgcccgccgg ggcttatcgt catgtcccgc     1140

aagatcatga gcgacatccc catgagcaac ggcaccatcc tgcccaaggg cctcttcgtg     1200

gccacctcca actacgatgc cacgagcgac gagtccgtcc tggggaatcc ggaccagttc     1260

gacgccttcc ggtacgagcg gatgcgcctg cagccgcagc agcggaacct gcaccagctc     1320

gtgtcgacca ggtgagctct tttttcaacc cccatcctat tccttcttcg caatgaatga     1380

ccccctacta agagcacatg cagcacgagt gaactctcgt ttggttttgg cacccacgcc     1440

tgtcccggcc gcttctttgc cgcctttgag atcaagatga tcctcatcta cttgctgctc     1500

aactacgacc tcaagttcca ggagggggtc ccgccacccc ggaatgagat cctcgtcacc     1560

gccgtcatgc cttctttcca gggcaaggtg atgatgaagc ggcgacgcga aaagatcgga     1620

tggcatgtcg actga                                                      1635


<210>  175
<211>  500
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  175

Met Asp Leu Leu Lys Glu Leu Asp Ala Pro Ser Leu Ala Pro Ser Leu 
1               5                   10                  15      


Leu Gly Thr Gly Val Val Leu Val Val Leu Tyr Phe Leu Thr Val Ser 
            20                  25                  30          


Ile Gln Asn Arg Ile Pro Pro Phe Asp Ala Pro Val Val Ser His Ala 
        35                  40                  45              


Lys Gly Phe Leu Ala Ala Leu Gln Glu Gly Lys Ala Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Pro Phe Ile Leu Asn Thr Pro His His Pro Thr Val Ile Leu Pro 
65                  70                  75                  80  


Arg Lys Trp Trp Glu Glu Leu Lys Ser Leu Pro Glu Ser His Ile Ser 
                85                  90                  95      


Phe Glu Ala Glu Arg Leu Tyr Arg Trp Gly Lys Gly Asn Pro Ile Ala 
            100                 105                 110         


Leu Val Asp His Val Thr Ile Glu Thr Thr Lys Asn Glu Leu Thr Arg 
        115                 120                 125             


His Thr Ala Arg Ser Phe Pro Leu Leu Leu Asp Glu Thr Val Tyr Ala 
    130                 135                 140                 


Val Asp Lys His Ile Gly Pro Cys Val Asp Trp Thr Pro Ile Thr Val 
145                 150                 155                 160 


Tyr Pro Thr Asp Leu Gln Leu Ile Ala Leu Leu Ser Ser Arg Thr Phe 
                165                 170                 175     


Val Gly Leu Pro Leu Ser Arg Asn Glu Arg Trp Leu Glu Ile Met Ile 
            180                 185                 190         


Arg Tyr Thr Ile Leu Ser Lys Ala Ala Ala Arg Ala Leu Trp Pro Tyr 
        195                 200                 205             


Pro Phe Leu Leu Arg Pro Ile Leu Gln Arg Phe Ala Pro Gln Ser Lys 
    210                 215                 220                 


Glu Leu Glu Lys Gln Arg Lys Glu Ala Ser Ala Leu Val Arg Pro Ile 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Ala Asp Leu Lys Arg Pro Asp Phe Lys Pro Pro 
                245                 250                 255     


Asn Asp Met Met Gln Trp Val Leu His Asn Cys Thr Pro Ala Glu Arg 
            260                 265                 270         


Glu Asp Ile Asp Phe Leu Val Gln Gln Gln Leu Thr Leu Ser Ile Val 
        275                 280                 285             


Ser Ile His Thr Thr Ala His Asn Leu Thr His Cys Ile Phe Asp Leu 
    290                 295                 300                 


Ala Ala His Pro Glu Cys Ile Glu Pro Leu Arg Gln Glu Phe Leu Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Thr Asn Gly Gln Ile Asp Lys Gln Leu Leu Thr Lys 
                325                 330                 335     


Cys Asn Lys Leu Asp Ser Phe Cys Lys Glu Ser Gln Arg Phe Cys Pro 
            340                 345                 350         


Pro Gly Leu Ile Val Met Ser Arg Lys Ile Met Ser Asp Ile Pro Met 
        355                 360                 365             


Ser Asn Gly Thr Ile Leu Pro Lys Gly Leu Phe Val Ala Thr Ser Asn 
    370                 375                 380                 


Tyr Asp Ala Thr Ser Asp Glu Ser Val Leu Gly Asn Pro Asp Gln Phe 
385                 390                 395                 400 


Asp Ala Phe Arg Tyr Glu Arg Met Arg Leu Gln Pro Gln Gln Arg Asn 
                405                 410                 415     


Leu His Gln Leu Val Ser Thr Ser Thr Ser Glu Leu Ser Phe Gly Phe 
            420                 425                 430         


Gly Thr His Ala Cys Pro Gly Arg Phe Phe Ala Ala Phe Glu Ile Lys 
        435                 440                 445             


Met Ile Leu Ile Tyr Leu Leu Leu Asn Tyr Asp Leu Lys Phe Gln Glu 
    450                 455                 460                 


Gly Val Pro Pro Pro Arg Asn Glu Ile Leu Val Thr Ala Val Met Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Lys Val Met Met Lys Arg Arg Arg Glu Lys Ile Gly 
                485                 490                 495     


Trp His Val Asp 
            500 


<210>  176
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 175

<400>  176

Met Asp Leu Leu Lys Glu Leu Ser Ala Pro Ser Leu Ala Pro Ser Leu 
1               5                   10                  15      


Leu Gly Thr Gly Val Val Leu Val Val Leu Tyr Phe Leu Thr Val Ser 
            20                  25                  30          


Ile Gln Leu Arg Ile Pro Pro Phe Asp Ala Pro Val Val Ser His Ala 
        35                  40                  45              


Ile Gly Phe Leu Ala Ala Leu Gln Glu Gly Lys Ala Lys Tyr Arg Asn 
    50                  55                  60                  


Ile Pro Phe Phe Leu Asn Thr Pro His His Pro Thr Val Ile Leu Pro 
65                  70                  75                  80  


Arg Lys Trp Trp Glu Glu Leu Lys Ser Leu Pro Glu Ser His Ile Ser 
                85                  90                  95      


Phe Glu Ala Glu Arg Leu Asp Arg Trp Gly Phe Gly Asn Pro Ile Ala 
            100                 105                 110         


Leu Val Asp His Val Thr Ile Glu Thr Thr Lys Asn Glu Leu Thr Arg 
        115                 120                 125             


Phe Thr Ala Arg Val Phe Pro Pro Leu Leu Asp Glu Thr Val Tyr Ala 
    130                 135                 140                 


Val Asp Lys His Ile Gly Pro Cys Val Asp Trp Thr Pro Ile Thr Val 
145                 150                 155                 160 


Tyr Pro Thr Asp Ala Gln Leu Ile Ala Leu Leu Ser Ser Arg Ala Phe 
                165                 170                 175     


Val Gly Leu Pro Leu Ser Arg Asn Glu Arg Trp Leu Glu Ile Met Ile 
            180                 185                 190         


Arg Tyr Gly His Leu Ser Lys Ala Ala Ala Arg Ala Leu Trp Pro Tyr 
        195                 200                 205             


Pro Phe Leu Leu Arg Pro Ile Leu Gln Arg Phe Ala Pro Gln Glu Lys 
    210                 215                 220                 


Glu Leu Ala Lys Gln Arg Lys Glu Ala Ser Ala Leu Val Arg Pro Ile 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Ala Asp Leu Lys Arg Pro Asp Val Lys Pro Pro 
                245                 250                 255     


Asn Asp Met Met Gln Trp Val Leu His Arg Asp Lys Pro Ala Glu Arg 
            260                 265                 270         


Glu Asp Ile Asp Phe Leu Val Gln Asp Gln Leu Thr Leu Ser Ile Val 
        275                 280                 285             


Ser Ile His Thr Thr Ala His Asn Leu Thr His Cys Ile Phe Leu Leu 
    290                 295                 300                 


Ala Ala His Pro Glu Cys Ile Glu Pro Leu Arg Gln Glu Phe Leu Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Thr Asn Gly Gln Ile Asp Glu Gln Leu Leu Thr Lys 
                325                 330                 335     


Cys Asn Lys Leu Asp Ser Phe Cys Lys Glu Ser Gln Arg Phe Cys Pro 
            340                 345                 350         


Pro Gly Leu Ile Val Met Ser Arg Lys Ile Met Ser Asp Ile Pro Met 
        355                 360                 365             


Ser Asn Gly Thr Thr Leu Pro Lys Gly Leu Phe Val Ala Thr Ser Asn 
    370                 375                 380                 


Tyr Asp Ala Thr Ser Asp Glu Ser Val Leu Gly Asn Pro Asp Gln Phe 
385                 390                 395                 400 


Asp Ala Phe Arg Tyr Glu Arg Met Arg Leu Gln Asp Gln Gln Arg Asn 
                405                 410                 415     


Leu His Gln Leu Val Ser Thr Ser Thr Ser Glu Leu Ser Phe Gly Phe 
            420                 425                 430         


Gly Thr His Ala Cys Pro Gly Arg Phe Phe Ala Ala Phe Glu Ile Lys 
        435                 440                 445             


Met Ile Leu Ile Tyr Leu Leu Leu Asn Tyr Asp Leu Lys Phe Gln Glu 
    450                 455                 460                 


Gly Val Pro Pro Pro Arg Asn Glu Ile Leu Val Thr Ala Val Met Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Lys Val Met Met Lys Arg Arg Arg Glu Lys Ile Gly 
                485                 490                 495     


Trp His Val Asp 
            500 


<210>  177
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 175

<400>  177

Met Asp Leu Leu Lys Glu Leu Asp Ala Thr Ser Leu Ala Pro Ser Leu 
1               5                   10                  15      


Leu Gly Thr Gly Val Val Leu Val Val Leu Tyr Phe Leu Thr Val Ser 
            20                  25                  30          


Ile Gln Asn Arg Ile Pro Pro Phe Asp Ala Pro Val Val Ser His Ala 
        35                  40                  45              


Lys Gly Phe Leu Ala Ala Leu Gln Glu Gly Lys Ala Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Pro Phe Ile Leu Asn Thr Pro His His Pro Thr Val Ile Leu Pro 
65                  70                  75                  80  


Arg Lys Asp Trp Glu Glu Leu Lys Ser Leu Pro Glu Ser Arg Ile Ser 
                85                  90                  95      


Phe Glu Ala Glu Arg Leu Tyr Arg Trp Gly Lys Gly Asn Pro Ile Ala 
            100                 105                 110         


Leu His Asp His Val Thr Ile Glu Thr Thr Lys Asn Glu Leu Thr Arg 
        115                 120                 125             


Asp Thr Ala Arg Ser Phe Pro Leu Leu Leu Asp Glu Thr Val Tyr Ala 
    130                 135                 140                 


Val Asp Lys His Ile Gly Pro Cys Val Asp Trp Thr Pro Ile Thr Val 
145                 150                 155                 160 


Tyr Pro Thr Asp Asp Arg Leu Ile Ala Leu Leu Ser Ser Arg Thr Phe 
                165                 170                 175     


Val Gly Leu Pro Leu Ser Glu Asp Glu Arg Trp Leu Glu Ile Met Ile 
            180                 185                 190         


Arg Tyr Thr Ile Leu Ser Lys Ala Ala Met Arg Ala Leu Val Pro Tyr 
        195                 200                 205             


Pro Phe Leu Leu Arg Pro Ile Leu Gly Arg Phe Leu Pro Gln Ser Lys 
    210                 215                 220                 


Glu Leu Glu Lys Asp Arg Lys Glu Ala Ser Ala Leu Val Arg Pro Ile 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Ala Asp Leu Lys Gly Pro Asp Phe Lys Lys Pro 
                245                 250                 255     


Asn Asp Met Met Gln Trp Val Leu His Asn Cys Thr Pro Ala Glu Arg 
            260                 265                 270         


Glu Asp Ile Asp Phe Leu Val Tyr Ile Gln Leu Thr Leu Ser Ile Val 
        275                 280                 285             


Ser Ile His Thr Thr Ala His Asn Leu Thr His Cys Ile Phe Asp Leu 
    290                 295                 300                 


Ala Ala His Pro Glu Cys Ile Glu Pro Leu Arg Gln Glu Phe Leu Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Asp Asn Gly Gln Ile Asp Lys Gln Leu Leu Thr Lys 
                325                 330                 335     


Cys Asn Lys Leu Asp Ser Phe Cys Lys Glu Ser Gln Arg Phe Cys Pro 
            340                 345                 350         


Pro Gly Leu Ile Val Met Ser Arg Lys Ile Arg Ser Asp Ile Pro Met 
        355                 360                 365             


Ser Asn Gly Thr Ile Leu Pro Lys Gly Leu Phe Val Ala Thr Ser Asn 
    370                 375                 380                 


Tyr Asp Ala Thr Ser Asp Glu Ser Val Leu Gly Asn Pro Asp Gln Phe 
385                 390                 395                 400 


Asp Ala Phe Arg Tyr Glu Arg Met Arg Leu Gln Pro Gln Gln Arg Asn 
                405                 410                 415     


Leu His Pro Leu Val Asp Thr Asn Thr Ser Glu Leu Ser Phe Gly Phe 
            420                 425                 430         


Gly Thr His Ala Cys Pro Gly Arg Phe Phe Ala Ala Phe Glu Ile Lys 
        435                 440                 445             


Met Ile Leu Ile Tyr Leu Leu Leu Asn Tyr Asp Leu Lys Phe Gln Glu 
    450                 455                 460                 


Gly Val Pro Pro Pro Arg Asn Glu Ile Leu Met Val Ala Val Met Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Lys Val Met Met Lys Arg Arg Arg Glu Lys Ile Gly 
                485                 490                 495     


Trp His Val Asp 
            500 


<210>  178
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 175

<400>  178

Met Asp Leu Leu Arg Glu Leu Asp Ala Pro Ser Leu Ala Pro Ser Leu 
1               5                   10                  15      


Leu Gly Thr Gly Val Val Leu Val Val Leu Tyr Phe Leu Thr Val Ser 
            20                  25                  30          


Ile Gln Asn Arg Ile Pro Pro Phe Asp Ala Pro Val Val Ser His Ala 
        35                  40                  45              


Lys Asn Phe Leu Ala Val Leu Gln Glu Gly Lys Ala Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Pro Phe Ile Leu Tyr Thr Pro His His Ile Thr Val Ile Leu Pro 
65                  70                  75                  80  


Arg Lys Trp Trp Glu Glu Leu Lys Ser Leu Pro Glu Thr His Ile Ser 
                85                  90                  95      


Phe Glu Ala Ile Arg Leu Tyr Val Trp Gly Lys Gly Asn Pro Ile Ala 
            100                 105                 110         


Leu Asn Asp His Val Arg Ile Glu Thr Thr Lys Asn Glu Leu Thr Arg 
        115                 120                 125             


Leu Thr Ala Arg Ser Phe Pro Leu Leu Leu Asp Glu Thr Val Tyr Ala 
    130                 135                 140                 


Val Asp Lys His Leu Gly Pro Cys Val Asp Trp Lys Pro Ile Thr Val 
145                 150                 155                 160 


Arg Pro Thr Asp Leu Gln Leu Ile Ala Leu Leu Ser Ser Arg Thr Phe 
                165                 170                 175     


Val Gly Leu Pro Leu Ser Leu Asn Glu Arg Trp Leu Glu Tyr Met Ile 
            180                 185                 190         


Arg Tyr Thr Ile Leu Ser Val Ala Ala Ala Arg Ala Leu Trp Trp Tyr 
        195                 200                 205             


Pro Arg Leu Leu Arg Arg Ile Leu Gln Arg Phe Thr Pro Gln Ser Lys 
    210                 215                 220                 


Glu Leu Glu Lys Ala Arg Lys Thr Ala Ser Ala Leu Val Arg Pro Ile 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Ala Asp Leu Lys Arg Pro Asp Gly Gly Pro Pro 
                245                 250                 255     


Asn Asp Met Met Gln Trp Val Leu His Asn Leu Thr Pro Ala Glu Arg 
            260                 265                 270         


Glu Asp Ile Asp Phe Leu Val Asp Gln Gln Leu Thr Leu Ser Ile Val 
        275                 280                 285             


Ser Ile His Thr Thr Ala Ser Asn Leu Thr His Cys Ile Phe Asp Leu 
    290                 295                 300                 


Ala Ala His Pro Glu Cys Ile Glu Pro Leu Arg Gln Glu Phe Leu Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Thr Asn Gly Gln Ile Asp Lys Gln Leu Leu Glu Lys 
                325                 330                 335     


Cys Asn Lys Leu Asp Ser Phe Cys Lys Glu Ser Gln Arg Phe Tyr Pro 
            340                 345                 350         


Pro Gly Leu Ile Val Met Ser Arg Lys Ile Met Ser Asp Ile Pro Met 
        355                 360                 365             


Ser Asn Gly Thr His Leu Pro Lys Gly Leu Phe Val Ala Thr Ser Asn 
    370                 375                 380                 


Tyr Asp Ala Thr Ser Asp Glu Ser Val Leu Gly Asn Pro Asp Gln Phe 
385                 390                 395                 400 


Asp Ala Phe Arg Tyr Glu Arg Ser Arg Leu Gln Pro Gln Gln Arg Glu 
                405                 410                 415     


Leu His Gln Leu Val Ser Thr Ser Gln Ser Glu Leu Ser Phe Gly Phe 
            420                 425                 430         


Gly Thr His Ala Cys Pro Gly Arg Phe Phe Ala Ala Phe Glu Ile Lys 
        435                 440                 445             


Met Ile Leu Ile Tyr Leu Leu Leu Asn Tyr Asp Leu Lys Phe Gln Glu 
    450                 455                 460                 


Gly Val Pro Pro Pro Arg Asn Glu Ile Leu Val Thr Ala Val Met Pro 
465                 470                 475                 480 


Ser Asp Gln Gly Lys Val Met Met Lys Arg Arg Arg Glu Lys Ile Gly 
                485                 490                 495     


Trp His Val Asp 
            500 


<210>  179
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 175

<400>  179

Met Asp Leu Leu Ala Glu Leu Asp Ala Pro Ser Leu Ala Pro Ser Leu 
1               5                   10                  15      


Leu Gly Thr Gly Val Val Leu Val Val Leu Tyr Phe Leu Thr Val Ser 
            20                  25                  30          


Ile Gln Asn Arg Ile Pro Pro Arg Asp Ala Pro Val Val Ser His Ala 
        35                  40                  45              


Leu Gly Phe Leu Ser Ala Leu Gln Glu Gly Lys Ala Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Pro Phe Arg Leu Asn Thr Pro His His Pro Thr Val Ile Leu Pro 
65                  70                  75                  80  


Arg Lys Trp Trp Glu Glu Leu Lys Gly Leu Pro Glu Ser His Ile Ser 
                85                  90                  95      


Phe Glu Ala Glu Arg Leu Tyr Arg Trp Gly Lys Gly Asn Pro Ile Ala 
            100                 105                 110         


Lys Met Asp His Val Thr Ile Glu Thr Thr Lys Asn Glu Leu Thr Arg 
        115                 120                 125             


His Thr Ala Arg Ser Phe Pro Ser Leu Thr Asp Glu Thr Val Gln Ala 
    130                 135                 140                 


Val Leu Lys His Val Gly Pro Cys Thr Asp Trp Arg Pro Ile Thr Val 
145                 150                 155                 160 


Tyr Pro Thr Asp Arg Phe Leu Ile Ala Leu Leu Ser Ser Arg Thr Phe 
                165                 170                 175     


Val Gly Ile Pro Tyr Ser Arg Asn Glu Arg Trp Leu Glu Ile Met Arg 
            180                 185                 190         


Arg Phe Thr Arg Leu Ser Lys Ala Ala Ala Arg Met Leu Gln Val Tyr 
        195                 200                 205             


Pro Phe Leu Leu Arg Pro Ile Leu Gln Arg Phe Ala Pro Gln Ser Lys 
    210                 215                 220                 


Glu Ile Glu Arg Gln Arg Ala Gly Ala Ser Ala Leu Val Arg Pro Ile 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Ala Asp Ile Lys Arg Pro Glu Phe Ser Pro Pro 
                245                 250                 255     


Asn Asp Met Met Gln Trp Val Leu His Asn Glu Gln Pro Ala Glu Arg 
            260                 265                 270         


Glu Asp Ile Asp Phe Leu Val Gln Gln Gln Leu Thr Leu Ser Ile Val 
        275                 280                 285             


Ser Ile His Thr Thr Ala His Asn Leu Thr His Cys Ile Phe Cys Leu 
    290                 295                 300                 


Ala Arg His Pro Glu Cys Ile Glu Pro Leu Arg Gln Glu Phe Leu Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Gly Asn Gly Gln Ile Asp Lys Gln Leu Leu Val Lys 
                325                 330                 335     


Cys Asn Lys Leu Asp Ser Phe Cys Lys Glu Ser Gln Arg Phe Cys Pro 
            340                 345                 350         


Pro Gly Leu Ile Val Met Ser Arg Lys Ile Met Ser Asp Ile Pro Met 
        355                 360                 365             


Ser Asn Gly Thr Thr Leu Pro Lys Gly Leu Gln Val Ala Thr Ser Ile 
    370                 375                 380                 


Tyr Asp Ala Thr Ser Asp Glu Ser Val Leu Gly Asn Pro Asp Gln Phe 
385                 390                 395                 400 


Asp Ala Phe Arg Tyr Glu Arg Ala Arg Leu Gln Pro Gln Gln Pro Lys 
                405                 410                 415     


Leu His Gln Leu Val Ser Thr Ser Arg Ala Glu Leu Ser Phe Gly Phe 
            420                 425                 430         


Gly Thr His Ala Cys Pro Gly Arg Phe Phe Ala Ala Phe Glu Ile Lys 
        435                 440                 445             


Met Ile Leu Ile Tyr Leu Leu Leu Asn Tyr Asp Leu Lys Phe Gln Glu 
    450                 455                 460                 


Gly Gln Pro Val Pro Arg Asn Glu Ile Leu Val Thr Ala Val Met Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Trp Val Ser Met Lys Arg Arg Arg Glu Lys Ile Gly 
                485                 490                 495     


Trp His Val Asp 
            500 


<210>  180
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 175

<400>  180

Met Asp Leu Leu Lys Glu Leu Asp Ala Pro Ser Leu Ala Pro Ser Leu 
1               5                   10                  15      


Leu Gly Thr Gly Val Val Leu Val Val Leu Tyr Phe Leu Thr Val Ser 
            20                  25                  30          


Ile Gln Asn Arg Ile Pro Pro Trp Asp Ala Pro Val Val Ser His Ala 
        35                  40                  45              


Pro Asn Phe Leu Asp Ala Leu Gln Glu Gly Lys Ala Lys Tyr Arg Asn 
    50                  55                  60                  


Gln Pro Phe Ile Leu Asn Thr Pro His Met Pro Thr Val Ile Leu Pro 
65                  70                  75                  80  


Arg Lys Trp Trp Glu Glu Leu Lys Ser Ser Pro Glu Ser His Ile Ser 
                85                  90                  95      


Phe Glu Ala Gln Arg Thr Tyr Phe Trp Gly Lys Gly Lys Pro Ile Ala 
            100                 105                 110         


Gln Asp Asp His Val Thr Ile Glu Thr Thr Lys Asn Ala Leu Thr Arg 
        115                 120                 125             


Glu Thr Asn Arg Ser Phe Pro Met Leu Leu Asp Glu Thr Val Tyr Ala 
    130                 135                 140                 


Val Asp Lys His Ile Gly Pro Cys Val Asp Trp Thr Pro Ile Thr Val 
145                 150                 155                 160 


Val Lys Thr Asp Leu Gln Leu Ile Ala Leu Leu Ser Ser Ala Thr Phe 
                165                 170                 175     


Val Gly Leu Pro Leu Ser Arg Asn Glu Thr Trp Leu Glu Ser Met Ile 
            180                 185                 190         


Arg Tyr Thr Ile Leu Ser Lys Ala Ala Ala Arg Ala Leu Trp Pro Tyr 
        195                 200                 205             


Pro Phe Leu Leu Arg Pro Ile Leu Gln Pro Phe Ala Pro Gly Ser Lys 
    210                 215                 220                 


Tyr Leu Glu Lys Gln Arg Ile Glu Ala Ser Ala Leu Val His Pro Ile 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Ala Asp Leu Lys Arg Pro Asp Phe Lys Pro Pro 
                245                 250                 255     


Asn Asp Met Met Gln His Val Leu Glu Asn Cys Val Pro Ala Glu Arg 
            260                 265                 270         


Glu Asp Ile Asp Phe Leu Val Asn Gln Gln Leu Thr Leu Ser Ile Val 
        275                 280                 285             


Ser Ile His Thr Thr Ala His Asn Leu Thr His Cys Ile Phe Tyr Leu 
    290                 295                 300                 


Ala Ala His Pro Glu Cys Ile Glu Pro Leu Arg Gln Glu Phe Leu Pro 
305                 310                 315                 320 


Leu Leu Arg Glu Thr Asn Gly Met Ile Asp Glu Gln Leu Leu Thr Lys 
                325                 330                 335     


Cys Asn Lys Leu Asp Ser Phe Cys Lys Glu Ser Gln Arg Phe Trp Pro 
            340                 345                 350         


Pro Gly Leu Ile Val Met Ser Arg Lys Ile Phe Ser Asp Ile Pro Met 
        355                 360                 365             


Pro Asn Gly Thr Ile Leu Pro Lys Gly Leu Gln Val Ala Thr Ser Ala 
    370                 375                 380                 


Tyr Asp Ala Thr Ser Asp Glu Ser Val Leu Gly Asn Pro Asp Gln Phe 
385                 390                 395                 400 


Asp Ala Phe Arg Tyr Glu Arg Pro Arg Leu Gln Pro Gln Gln Arg Arg 
                405                 410                 415     


Leu His Gln Leu Ser Ser Thr His Thr Ser Glu Leu Ser Phe Gly Phe 
            420                 425                 430         


Gly Thr His Lys Cys Pro Gly Arg Arg Phe Ala Leu Phe Glu Ile Lys 
        435                 440                 445             


Met Ile Leu Ile Tyr Leu Leu Leu Asn Tyr Asp Leu Lys Phe Gln Glu 
    450                 455                 460                 


Gly Val Pro Pro Pro Lys Asn Ile Ile Ser Val Thr Ala Val Lys Pro 
465                 470                 475                 480 


Ser Phe Gln Gly Lys Val Met Met Lys Arg Arg Ile Glu Lys Ile Gly 
                485                 490                 495     


Trp His Val Asp 
            500 


<210>  181
<211>  1509
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  181
atgtcggcag aagcagagaa gcagtcctcc tctccggccg actccagcct ccagaccatc       60

catgatgacc gcgaccaacc cccgggcgat gcggaggatc cgaccctcat cacctgggat      120

ggacccgacg acccagccaa ccccaagaac tggtcccggc ggcgtaaatg ggcggcgacg      180

atggtcgtgt ccggcttcaa cttcatctcg ccgctggcca gcgccatgat cgccccgtgt      240

ttgcccgcgc tggctgccga gctggacatc acctcctccg tcgagcagag catggcgctc      300

agcgtcttcg tcctgggcta cgcggtcggc ccgctcgtgg tcggtccctt gtccgagctg      360

tacgggcgcg tgcccgtgtt gcagacgagc aacctggtgt ttctgctgtt caacctcgcc      420

tgtggcctgg cccggaccaa gggcgagatg atcgccttcc gcttcatcgc cggcctgggg      480

ggctccgcgc cccaggccac cggcggcggc gtcctggggg atctctgggc caccgaggag      540

cgtggccgcg cgctggcctt ctacagcctg gcgccgctgc tggggccggc cgttgggccc      600

atcgcgggcg gcttcgtcgc ggagaatacg agctggcgct ggatcttcta cgccaccacc      660

atctccaacg gggtcgtcat gctgctgggc ttcctcctcc tgcaggagac ccgggcctcc      720

gtcctgctgg agcgcaagaa gcgccgccgc atccgtgaga ccggcagcaa ggcgtggcat      780

accgagactg ataacccgga tcacaccctg cgcaacatca tcctgaccgc gctcaaccgg      840

cccttccgcc tgctcttcac ccagccgatc gtgcaggtgc tggccgtgta cctggcctac      900

atctacggca tcgtgtactt ggtgctcgcc agtttcccgg atctctggac ctcccccgat      960

cactacggtg agtcggtcgg catcggcgga ctgaactaca tcgccctcgc gtgtgggttc     1020

ttgctgggcg cctatctgtg tgcgcccacg caggaccgga tctaccgtcg gttgaaggat     1080

cgcaacggcg gcgtgggccg gccggaatac cgcatcccgc tgatgatccc cagtgccatc     1140

ctcgtgcccg tcggtctttt catctacggc tggaccgccg agtaccgaac gttctggatc     1200

ggcccggaca tcggcatcgc cctgtatgcc gcgggctaca tcaccagctt ccagtgcgtc     1260

caggtctata tcgtcgacac gtacaccaat tatgcggcat cggcgctggc ctcggtgacc     1320

gtgctgcgca gtctctgtgc cttcaccttt ccgctgtttg ccccgaagat gtatgatgcg     1380

ctggggtatg gctggggaaa ctcgatgctg gccttcatcg ccatggggct cggatggccg     1440

ggtccgtttg tgttgtggcg ctatgggcag gctctgcgag agcgcagtcc atatgccgca     1500

gagatataa                                                             1509


<210>  182
<211>  502
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  182

Met Ser Ala Glu Ala Glu Lys Gln Ser Ser Ser Pro Ala Asp Ser Ser 
1               5                   10                  15      


Leu Gln Thr Ile His Asp Asp Arg Asp Gln Pro Pro Gly Asp Ala Glu 
            20                  25                  30          


Asp Pro Thr Leu Ile Thr Trp Asp Gly Pro Asp Asp Pro Ala Asn Pro 
        35                  40                  45              


Lys Asn Trp Ser Arg Arg Arg Lys Trp Ala Ala Thr Met Val Val Ser 
    50                  55                  60                  


Gly Phe Asn Phe Ile Ser Pro Leu Ala Ser Ala Met Ile Ala Pro Cys 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Ala Glu Leu Asp Ile Thr Ser Ser Val Glu Gln 
                85                  90                  95      


Ser Met Ala Leu Ser Val Phe Val Leu Gly Tyr Ala Val Gly Pro Leu 
            100                 105                 110         


Val Val Gly Pro Leu Ser Glu Leu Tyr Gly Arg Val Pro Val Leu Gln 
        115                 120                 125             


Thr Ser Asn Leu Val Phe Leu Leu Phe Asn Leu Ala Cys Gly Leu Ala 
    130                 135                 140                 


Arg Thr Lys Gly Glu Met Ile Ala Phe Arg Phe Ile Ala Gly Leu Gly 
145                 150                 155                 160 


Gly Ser Ala Pro Gln Ala Thr Gly Gly Gly Val Leu Gly Asp Leu Trp 
                165                 170                 175     


Ala Thr Glu Glu Arg Gly Arg Ala Leu Ala Phe Tyr Ser Leu Ala Pro 
            180                 185                 190         


Leu Leu Gly Pro Ala Val Gly Pro Ile Ala Gly Gly Phe Val Ala Glu 
        195                 200                 205             


Asn Thr Ser Trp Arg Trp Ile Phe Tyr Ala Thr Thr Ile Ser Asn Gly 
    210                 215                 220                 


Val Val Met Leu Leu Gly Phe Leu Leu Leu Gln Glu Thr Arg Ala Ser 
225                 230                 235                 240 


Val Leu Leu Glu Arg Lys Lys Arg Arg Arg Ile Arg Glu Thr Gly Ser 
                245                 250                 255     


Lys Ala Trp His Thr Glu Thr Asp Asn Pro Asp His Thr Leu Arg Asn 
            260                 265                 270         


Ile Ile Leu Thr Ala Leu Asn Arg Pro Phe Arg Leu Leu Phe Thr Gln 
        275                 280                 285             


Pro Ile Val Gln Val Leu Ala Val Tyr Leu Ala Tyr Ile Tyr Gly Ile 
    290                 295                 300                 


Val Tyr Leu Val Leu Ala Ser Phe Pro Asp Leu Trp Thr Ser Pro Asp 
305                 310                 315                 320 


His Tyr Gly Glu Ser Val Gly Ile Gly Gly Leu Asn Tyr Ile Ala Leu 
                325                 330                 335     


Ala Cys Gly Phe Leu Leu Gly Ala Tyr Leu Cys Ala Pro Thr Gln Asp 
            340                 345                 350         


Arg Ile Tyr Arg Arg Leu Lys Asp Arg Asn Gly Gly Val Gly Arg Pro 
        355                 360                 365             


Glu Tyr Arg Ile Pro Leu Met Ile Pro Ser Ala Ile Leu Val Pro Val 
    370                 375                 380                 


Gly Leu Phe Ile Tyr Gly Trp Thr Ala Glu Tyr Arg Thr Phe Trp Ile 
385                 390                 395                 400 


Gly Pro Asp Ile Gly Ile Ala Leu Tyr Ala Ala Gly Tyr Ile Thr Ser 
                405                 410                 415     


Phe Gln Cys Val Gln Val Tyr Ile Val Asp Thr Tyr Thr Asn Tyr Ala 
            420                 425                 430         


Ala Ser Ala Leu Ala Ser Val Thr Val Leu Arg Ser Leu Cys Ala Phe 
        435                 440                 445             


Thr Phe Pro Leu Phe Ala Pro Lys Met Tyr Asp Ala Leu Gly Tyr Gly 
    450                 455                 460                 


Trp Gly Asn Ser Met Leu Ala Phe Ile Ala Met Gly Leu Gly Trp Pro 
465                 470                 475                 480 


Gly Pro Phe Val Leu Trp Arg Tyr Gly Gln Ala Leu Arg Glu Arg Ser 
                485                 490                 495     


Pro Tyr Ala Ala Glu Ile 
            500         


<210>  183
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 182

<400>  183

Met Ser Ala Glu Ala Glu Lys Gln Ser Ser Ser Pro Ala Asp Ser Ser 
1               5                   10                  15      


Leu Gln Thr Ile His Asp Pro Arg Asp Gln Pro Pro Gly Asp Ala Glu 
            20                  25                  30          


Asp Pro Thr Leu Ile Leu Glu Asp Gly Phe Asp Asp Pro Ala Asn Pro 
        35                  40                  45              


Lys Asn Trp Ser Arg Arg Arg Lys Pro Ala Ala Thr Met Val Val Ser 
    50                  55                  60                  


Gly Phe Asn Phe Ile Glu Pro Leu Ala Asn Ala Met Ile Ala Pro Cys 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Ala Glu Leu Asp Ile Thr Ser Ser Val Glu Gln 
                85                  90                  95      


Ser Met Ala Leu Ser Val Phe Val Leu Gly Tyr Ala Val Gly Pro Leu 
            100                 105                 110         


Val Val Gly Pro Leu Ser Glu Leu Tyr Gly Arg Val Pro Val Leu Gln 
        115                 120                 125             


Thr Ser Asn Leu Val Phe Leu Leu Phe Asn Leu Ala Ile Gly Leu Ala 
    130                 135                 140                 


Thr Thr Lys Gly Glu Met Ile Ala Phe Arg Phe Ile Ala Gly Leu Gly 
145                 150                 155                 160 


Gly Ser Ala Pro Gln Ala Thr Gly Phe Gly Val Leu Gly Asp Leu Trp 
                165                 170                 175     


Ala Thr Glu Met Arg Gly Arg Ala Leu Ala Phe Tyr Ser Leu Ala Pro 
            180                 185                 190         


Leu Leu Gly Pro Ala Val Gly Pro Ile Ala Gly Gly Phe Val Ala Glu 
        195                 200                 205             


Asn Thr Ser Trp Arg Trp Ile Phe Tyr Ala Thr Thr Ile Ser Asn Gly 
    210                 215                 220                 


Val Val Met Leu Leu Gly Phe Leu Leu Leu Gln Glu Thr Arg Ala Ser 
225                 230                 235                 240 


Val Leu Leu Glu Arg Lys Lys Arg Arg Arg Ile Lys Glu Thr Gly Ser 
                245                 250                 255     


Lys Ala Trp Gln Thr Glu Trp Asp Leu Pro Pro His Thr Ala Arg Asn 
            260                 265                 270         


Ile Ile Leu Ile Ala Leu Asn Arg Pro Phe Arg Leu Leu Phe Thr Gln 
        275                 280                 285             


Pro Ile Val Gln Val Leu Ala Val Tyr Leu Ala Tyr Asn Tyr Gly Ile 
    290                 295                 300                 


Leu Tyr Leu Val Leu Ala Ser Phe Pro Asp Leu Trp Val Ser Pro Asp 
305                 310                 315                 320 


His Tyr Gly Glu Ser Val Gly Ile Gly Gly Leu Asn Tyr Ile Ala Leu 
                325                 330                 335     


Ala Cys Gly Phe Leu Leu Gly Ala Tyr Leu Cys Ala Pro Thr Gln Asp 
            340                 345                 350         


Arg Ile Tyr Arg Arg Leu Lys Asp Arg Asn Gly Gly Val Gly Arg Pro 
        355                 360                 365             


Glu Tyr Arg Ile Pro Leu Met Ile Pro Ser Ala Ile Leu Val Pro Val 
    370                 375                 380                 


Gly Leu Phe Ile Tyr Gly Trp Thr Pro Glu Tyr Arg Thr Thr Trp Ile 
385                 390                 395                 400 


Gly Pro Asp Ile Gly Ile Ala Leu Tyr Ala Ala Gly Tyr Ile Thr Ser 
                405                 410                 415     


Phe Gln Cys Val Gln Val Tyr Ile Val Asp Val Tyr Thr Asn Tyr Ala 
            420                 425                 430         


Ala Ser Ala Leu Ala Ser Ser Thr Val Leu Arg Ser Leu Cys Ala Phe 
        435                 440                 445             


Thr Phe Pro Leu Phe Ala Pro Lys Met Tyr Asp Ala Leu Gly Tyr Gly 
    450                 455                 460                 


Trp Gly Asn Ser Met Leu Ala Phe Ile Ala Met Gly Leu Gly Trp Pro 
465                 470                 475                 480 


Gly Pro Phe Val Leu Trp Arg Tyr Gly Gln Ala Leu Arg Glu Arg Thr 
                485                 490                 495     


Pro Tyr Ala Ala Glu Ile 
            500         


<210>  184
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 182

<400>  184

Met Ser Ala Glu Ala Glu Lys Gln Thr Ser Ser Pro Ala Leu Ala Ser 
1               5                   10                  15      


Leu Gln Thr Leu Gln Asp Asp Arg Asp Gln Pro Pro Gly Asp Ala Glu 
            20                  25                  30          


Asp Val Thr Leu Ile Thr Trp Asp Gly Pro Asp Asp Thr Ala Asn Pro 
        35                  40                  45              


Lys Asn Trp Ser Gly Arg Arg Lys Trp Ala Ala Thr Met Val Val Ser 
    50                  55                  60                  


Gly Phe Asn Phe Ile Gln Pro Leu Ala Ile Ala Met Ile Ala Pro Cys 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Ala Glu Leu Asp Ile Thr Ser Gly Val Glu Gln 
                85                  90                  95      


Ser Met Ala Leu Ser Val Phe Val Leu Gly Tyr Ala Val Gly Pro Leu 
            100                 105                 110         


Val Val Gly Pro Leu Ser Glu Leu Tyr Gly Arg Val Pro Val Leu Gln 
        115                 120                 125             


Thr Ser Asn Leu Val Phe Leu Leu Phe Asn Leu Ala Cys Gly Leu Ala 
    130                 135                 140                 


Arg Thr Lys Gly Glu Met Ile Ala Phe Arg Phe Ile Ala Gly Leu Gly 
145                 150                 155                 160 


Gly Ser Ala Pro Gln Ala Thr Gly Gly Gly Val Leu Gly Asp Leu Trp 
                165                 170                 175     


Ala Thr Glu Glu Arg Gly Arg Ala Leu Ala Phe Tyr Ser Leu Ala Leu 
            180                 185                 190         


Leu Leu Gly Pro Ala Val Gly Pro Ile Ala Gly Gly Phe Val Ala Glu 
        195                 200                 205             


Thr Thr Ser Trp Arg Trp Ile Phe Tyr Ala Thr Thr Ile Ser Asn Gly 
    210                 215                 220                 


Val Val Met Leu Leu Gly Phe Leu Leu Leu Gln Glu Thr Arg Ala Ser 
225                 230                 235                 240 


Pro Gln Leu Glu Arg Lys Lys Arg Arg Arg Ile Arg Glu Thr Gly Ser 
                245                 250                 255     


Lys Ala Trp Val Thr Glu Thr His Asn Ala Asp His Arg Leu Lys Asn 
            260                 265                 270         


Ile Ile Leu Thr Ala Leu Asn Arg Pro Phe Asp Leu Leu Phe Thr Glu 
        275                 280                 285             


Pro Ile Val Gln Val Leu Ala Val Tyr Leu Ala Tyr Gln Tyr Gly Ile 
    290                 295                 300                 


Val Tyr Leu Val Leu Ala Ser Phe Pro Asp Leu Trp Thr Ser Pro Asp 
305                 310                 315                 320 


His Tyr Gly Glu Ser Val Gly Ile Gly Gly Leu Asn Tyr Ile Ala Leu 
                325                 330                 335     


Ala Cys Gly Phe Leu Leu Gly Ala Tyr Leu Cys Ala Pro Thr Gln Asp 
            340                 345                 350         


Arg Ile Tyr Arg Arg Leu Lys Asp Arg Asn Gly Gly Val Ser Arg Pro 
        355                 360                 365             


Glu Tyr Arg Ile Pro Leu Met Ile Pro Ser Ala Ile Leu Val Pro Val 
    370                 375                 380                 


Gly Leu Phe Ile Tyr Gly Trp Thr Phe Glu Tyr Arg Thr Phe Trp Ile 
385                 390                 395                 400 


Gly Pro Asp Ile Gly Ile Ala Leu Tyr Ala Ala Gly Tyr Ile Thr Ser 
                405                 410                 415     


Phe Gln Cys Val Gln Val Tyr Ile Val Asp Thr Tyr Thr Asn Tyr Ala 
            420                 425                 430         


Ala Ser Ala Leu Ala Ser Val Thr Val Leu Arg Ser Leu Cys Ala Phe 
        435                 440                 445             


Thr Phe Pro Leu Phe Ala Pro Lys Met Tyr Asp Ala Leu Gly Tyr Gly 
    450                 455                 460                 


Trp Gly Asn Ser Met Leu Ala Phe Ile Ala Met Gly Leu Gly Trp Pro 
465                 470                 475                 480 


Gly Pro Phe Val Leu Trp Arg Tyr Gly Gln Ala Leu Arg Glu Arg Pro 
                485                 490                 495     


Pro Tyr Ala Ala Glu Ile 
            500         


<210>  185
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 182

<400>  185

Met Ser Ala Glu Ala Glu Lys Asn Ser Ser Ser Pro Ala Asp Ser Ser 
1               5                   10                  15      


Leu Gln Thr Ile His Asp Ala Arg Ser Gly Pro Pro Asp Asp Ala Glu 
            20                  25                  30          


Ala Pro Glu Leu Ile Thr Ser Asp Ser Pro Asn Leu Pro Ala Asn Pro 
        35                  40                  45              


Lys Asn Trp Ser Pro Arg Arg Pro Trp Ala Ala Thr Met Val Val Ser 
    50                  55                  60                  


Gly Phe Asn Phe Ile Phe Pro Leu Ala Ile Ala Met Ile Ala Pro Cys 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Ala Glu Leu Asp Ile Thr Ser Ser Val Glu Gln 
                85                  90                  95      


Ser Met Ala Leu Ser Val Phe Val Leu Gly Tyr Ala Val Gly Pro Leu 
            100                 105                 110         


Val Val Gly Pro Leu Ser Glu Leu Tyr Gly Arg Val Pro Val Leu Gln 
        115                 120                 125             


Thr Ser Asn Leu Val Ser Leu Leu Phe Asn Leu Ala Phe Gly Leu Ala 
    130                 135                 140                 


Gly Thr Lys Gly Glu Met Ile Ala Phe Arg Phe Ile Ala Gly Leu Gly 
145                 150                 155                 160 


Gly Ser Ala Pro Gln Ala Thr Gly Gly Gly Val Leu Gly Asp Leu Trp 
                165                 170                 175     


Ala Thr Glu Glu Arg Gly Arg Ala Leu Ala Phe Tyr Ser Leu Ala Ala 
            180                 185                 190         


Leu Leu Gly Gly Ala Val Gly Pro Ile Ala Gly Gly Phe Val Ala Glu 
        195                 200                 205             


His Thr Ser Trp Arg Trp Ile Phe Tyr Ala Thr Thr Ile Ser Asn Gly 
    210                 215                 220                 


Val Val Met Leu Leu Gly Phe Leu Leu Leu Gln Glu Thr Arg Ala Thr 
225                 230                 235                 240 


Val Leu Leu Glu Arg Lys Lys Ala Lys Arg Ile Arg Glu Lys Gly Ser 
                245                 250                 255     


Lys Ala Trp His Thr Arg Thr Asp Asp Pro Trp His Thr Leu Arg Asn 
            260                 265                 270         


Ile Ile Leu His Ala His Ser Arg Pro Phe Arg Leu Leu Phe Thr Gln 
        275                 280                 285             


Pro Ile Val Gln Val Leu Ala Val Tyr Leu Ala Tyr Ile Tyr Gly Ile 
    290                 295                 300                 


Val Tyr Leu Val Leu Ala Ser Phe Pro Asp Leu Trp Thr Ser Pro Asp 
305                 310                 315                 320 


His Tyr Gly Glu Ser Val Gly Ile Gly Gly Leu Asn Tyr Ile Ala Leu 
                325                 330                 335     


Ala Cys Gly Phe Leu Leu Gly Ala Tyr Leu Cys Ala Pro Thr Gln Asp 
            340                 345                 350         


Arg Ile Tyr Arg Arg Arg Lys Asp Arg Asn Gly Gly Val Gly Arg Pro 
        355                 360                 365             


Glu Tyr Arg Ile Pro Leu Met Ile Pro Ser Ala Ile Leu Val Pro Val 
    370                 375                 380                 


Gly Leu Phe Ile Tyr Gly Trp Thr Ala Glu Tyr Ala Thr Phe Trp Ile 
385                 390                 395                 400 


Gly Pro Asp Ile Gly Ile Ala Leu Tyr Ala Ala Gly Asn Ile Thr Ser 
                405                 410                 415     


Phe Gln Cys Arg Gln Val Tyr Ile Val Asp Thr Tyr Thr Asn Tyr Ala 
            420                 425                 430         


Ala Ser Ala Leu Ala Ser Val Thr Val Leu Arg Gly Leu Cys Ala Phe 
        435                 440                 445             


Thr Phe Pro Leu Phe Ala Pro Lys Met Tyr Asp Ala Leu Gly Tyr Gly 
    450                 455                 460                 


Trp Gly Asn Ser Met Leu Ala Phe Ile Ala Met Gly Leu Gly Trp Pro 
465                 470                 475                 480 


Gly Pro Phe Val Leu Trp Arg Tyr Gly Gln Ala Leu Arg Glu Arg Ser 
                485                 490                 495     


Pro Tyr Ala Ala Glu Ile 
            500         


<210>  186
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 182

<400>  186

Met Ser Ala Glu Ala Glu Lys Pro Ser Gln Ser Pro Pro Asp Ser Thr 
1               5                   10                  15      


Leu Gln Thr Ile Val Asp Asp Arg Asp Gln Pro Pro Gly Asp Ala Glu 
            20                  25                  30          


Gly Pro Glu Leu Ile Thr Trp Asp Gly Glu Ser Asp Pro Phe Asn Pro 
        35                  40                  45              


Lys Thr Trp Ser Arg Arg Arg Ala Trp Ala Ala Thr Met Val Val Ser 
    50                  55                  60                  


Gly Phe Asn Phe Ile Ser Trp Leu Ala Ser Thr Met Ile Ala Pro Cys 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Ala Glu Leu Asp Ile Thr Pro Ile Val Glu Gln 
                85                  90                  95      


Ser Met Ala Leu Ser Val Phe Val Leu Gly Tyr Ala Val Gly Pro Leu 
            100                 105                 110         


Val Val Gly Phe Leu Ser Glu Leu Tyr Gly Arg Val Pro Val Leu Gln 
        115                 120                 125             


Thr Ser Asn Leu Val Gly Leu Leu Phe Asn Leu Ala Thr Gly Leu Ala 
    130                 135                 140                 


Arg Thr Lys Gly Glu Met Ile Ala Phe Arg Phe Ile Ala Gly Leu Gly 
145                 150                 155                 160 


Gly Ser Ala Pro Asn Ala Thr Gly Met Gly Val Leu Gly Asp Leu Trp 
                165                 170                 175     


Ala Thr Glu Glu Arg Gly Arg Ala Leu Ala Phe Tyr Ser Leu Ala Pro 
            180                 185                 190         


Leu Leu Gly Pro Ala Val Gly Pro Ile Ala Gly Gly Phe Val Ala Glu 
        195                 200                 205             


Asn Thr Ser Trp Arg Trp Ile Phe Tyr Ala Pro Thr Ile Ser Asn Gly 
    210                 215                 220                 


Val Val Met Leu Leu Gly Phe Leu Leu Leu Gln Glu Thr Arg Gly Ser 
225                 230                 235                 240 


Val Leu Thr Glu Arg Arg Arg Arg Arg Arg Ile Arg Glu Thr Gly Ser 
                245                 250                 255     


Lys Ala Trp Arg Thr Glu Thr Asp Asp Pro Asp Arg Thr Leu Glu Asn 
            260                 265                 270         


Thr Ile Glu Thr Arg Ile Leu Gly Pro Phe Arg Leu Leu Phe Thr Gln 
        275                 280                 285             


Pro Ile Val Gln Val Leu Ala Val Tyr Leu Ala Tyr Ile Tyr Gly Ile 
    290                 295                 300                 


Val Tyr Leu Val Leu Ala Ser Phe Pro Ile Leu Trp Asn Ser Leu Asp 
305                 310                 315                 320 


His Tyr Gly Glu Ser Val Gly Ile Gly Gly Leu Asn Tyr Ile Ala Leu 
                325                 330                 335     


Ala Cys Gly Asp Leu Leu Gly Ala Tyr Leu Cys Ala Pro Thr Gln Asp 
            340                 345                 350         


Arg Ile Tyr Arg Arg Leu Lys Asp Arg Asn Gly Gly Val Gly Arg Pro 
        355                 360                 365             


Glu Tyr Arg Ile Tyr Leu Met Ile Pro Ser Ala Ile Leu Ala Pro Val 
    370                 375                 380                 


Gly Leu Phe Ile Tyr Gly Trp Thr Ala Val Ala His Thr Phe Trp Ile 
385                 390                 395                 400 


Gly Pro Asp Ile Gly Ile Ala Leu Tyr Ala Ala Gly Tyr Ile Thr Ser 
                405                 410                 415     


Phe Gln Cys Val Gln Val Tyr Ile Val Asp Thr Tyr Thr Asn Tyr Ala 
            420                 425                 430         


Ala Ser Ala Leu Ala Ser Val Ile Val Leu Tyr Leu Leu Cys Ala Phe 
        435                 440                 445             


Thr Phe Pro Leu Phe Ala Pro Lys Met Tyr Asp Ala Leu Gly Tyr Gly 
    450                 455                 460                 


Tyr Gly Asn Ser Met Leu Ala Phe Ile Ala Met Gly Leu Gly Trp Pro 
465                 470                 475                 480 


Gly Pro Phe Val Leu Trp Arg Tyr Gly Gln Ala Thr Arg Glu Arg Ser 
                485                 490                 495     


Pro Arg Ala Ala Glu Ile 
            500         


<210>  187
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 182

<400>  187

Met Ser Gln Thr Ala Glu Lys Gln Leu Ser Ser Pro Ala Asp Ser Thr 
1               5                   10                  15      


Leu Gln Thr Ile His Asp Glu Arg Asp Gln Lys Pro Gly Asp Ala Glu 
            20                  25                  30          


Ser Gly Gly Leu Ile Thr Trp Asp Pro Pro Asp Asp Pro Ala Leu Pro 
        35                  40                  45              


Lys Asn Trp Ser Arg Arg Tyr Leu Trp Ala Ala Thr Met Val Val Ser 
    50                  55                  60                  


Gly Phe Asn Phe Ile Ser Pro Leu Ala Ser Ala Met Ile Ala Pro Cys 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Ala Glu Leu Asp Ile Thr Pro Ser Val Glu Gln 
                85                  90                  95      


Ser Met Ala Leu Ser Val Phe Val Leu Gly Tyr Ala Val Gly Pro Leu 
            100                 105                 110         


Val Val Gly Pro Leu Ser Glu Leu Tyr Gly Arg Val Pro Val Leu Gln 
        115                 120                 125             


Thr Ser Asn Leu Val Phe Leu Leu Phe Asn Leu Ala Cys Gly Leu Ala 
    130                 135                 140                 


Arg Thr Lys Gly Glu Met Ile Ala Phe Arg Phe Ile Ala Gly Leu Gly 
145                 150                 155                 160 


Asp Ser Ala Pro Gln Ala Thr Gly Gly Gly Val Leu Gly Asp Leu Trp 
                165                 170                 175     


Ala Thr Glu Glu Arg Gly Arg Ala Leu Ala Phe Leu Ser Leu Ala Pro 
            180                 185                 190         


Leu Leu Gly Pro Ala Val Gly Pro Ile Ala Gly Gly Phe Val Ala Glu 
        195                 200                 205             


Asn Thr Ser Trp Arg Trp Ile Phe Tyr Ala Phe Thr Ile Ser Asn Gly 
    210                 215                 220                 


Val Val Met Leu Leu Gly Phe Leu Leu Leu Gln Glu Thr Arg Ala Trp 
225                 230                 235                 240 


Val Val Arg Lys Arg Lys Lys Arg Thr Ile Ile Arg Lys Gln Ala Asn 
                245                 250                 255     


Gly Ala Trp Gly Phe Ile Glu Thr Asn Leu Gly His Ser Ser Arg Asn 
            260                 265                 270         


Leu Ile Glu Thr Ala Leu Asn Ser Pro Phe Arg Thr Leu Phe Thr Ile 
        275                 280                 285             


Pro Ile Val Gln Val Leu Ala Val Tyr Leu Ala Tyr Val Tyr Gly Ile 
    290                 295                 300                 


Val Tyr Leu Val Leu Ala Ser Phe Pro Asp Leu Trp Thr Thr Pro Asp 
305                 310                 315                 320 


His Tyr Gly Glu Ser Val Gly Ile Gly Gly Leu Asn Tyr Ile Ala Leu 
                325                 330                 335     


Ala Cys Gly Phe Leu Leu Gly Ala Tyr Leu Cys Ala Pro Thr Gln Asp 
            340                 345                 350         


Arg Ile Tyr Arg Arg Leu Lys Arg Arg Asn Gly Gly Val Gly Arg Pro 
        355                 360                 365             


Glu Tyr Arg Ile Pro Leu Met Ile Pro Ser Ala Ile Leu Val Pro Val 
    370                 375                 380                 


Gly Leu Phe Ile Tyr Gly Trp Thr Ala Glu Tyr Ser Thr Phe Trp Ile 
385                 390                 395                 400 


Gly Pro Asp Ile Gly Ile Ala Leu Tyr Ala Ala Gly Tyr Ile Thr Ser 
                405                 410                 415     


Phe Gln Cys Val Phe Val Tyr Ile Val Asp Thr Tyr Thr Asn Tyr Ala 
            420                 425                 430         


Ala Ser Ala Leu Ala Ser Ser Thr Val Leu Gln Ser Leu Cys Ala Phe 
        435                 440                 445             


Thr Phe Pro Leu Phe Ala Pro Lys Met Tyr Asp Ala Leu Gly Tyr Gly 
    450                 455                 460                 


Trp Gly Asn Ser Met Leu Ala Phe Ile Ala Met Gly Leu Gly Trp Pro 
465                 470                 475                 480 


Gly Pro Phe Val Leu His Arg Tyr Gly Gln Ala Leu Arg Glu Arg Ser 
                485                 490                 495     


Pro Tyr Ala Tyr Glu Ile 
            500         


<210>  188
<211>  952
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  188
atgtccggac acaacaaagc ctgtctctgc ctgcccgtcg cggtggtcga cgactaccaa       60

gcgaagggca gatatgaaac ggtgctggac acgaagacat gtacgtatat acttaccgat      120

ccccatttgc gacacacatc tgcgaaatgt cccgcctaac actcttttct gacggaggat      180

gtagacatca ctggtccgtc cgacgcctct cgcgcccttt tgctgatata cgacgccttt      240

ggatactcgc cccagctcct gcagggcgcc gatatcctgg cggcgtcgct gaatgccctg      300

gtggtggtcc cggacttctt caagggcaag gtggcctccg agtcctggtt ccccccggac      360

accgaagaaa agaaggccgt atgtccgact tgaacgctgt atgcgaatct ccagctgatt      420

tctggtccag gccattggcg actggtttgc cacggcgggc aactttgccg tgcatatcga      480

accgatgaag gaactcgtcc agcagctctc gacgcagtat cccagcgtga gcggcaaatg      540

gggcgcgttc ggctactgct ggggaggcaa gatggtcgcg ttgacgtcag gtgaagggac      600

cattttcaag acatccggcc agacgcaccc agggcaagtc ccttgaccat ttccctttga      660

gatctcaatc gacactaacc atggggggtg ttgcagaatg ctctcggccg acgatgtctc      720

caagatcaac atcccccata tcatcctggc gtcgaaggac gaagatgcca ccgcggtggc      780

cgagtgcaag aaggtcctcg agggtcccgg caagacaggc ctggtaaagt cgtatccgga      840

ccagatccac ggctggatgg ccgcccgtgc caatctgaag gacgagacgg tccgcaaggc      900

gtttgaagat gggtacaaga ccgccgcgga gttttttgag cagcatcttt aa              952


<210>  189
<211>  250
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  189

Met Ser Gly His Asn Lys Ala Cys Leu Cys Leu Pro Val Ala Val Val 
1               5                   10                  15      


Asp Asp Tyr Gln Ala Lys Gly Arg Tyr Glu Thr Val Leu Asp Thr Lys 
            20                  25                  30          


Thr Tyr Ile Thr Gly Pro Ser Asp Ala Ser Arg Ala Leu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Phe Gly Tyr Ser Pro Gln Leu Leu Gln Gly Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Ser Leu Asn Ala Leu Val Val Val Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gly Lys Val Ala Ser Glu Ser Trp Phe Pro Pro Asp Thr Glu Glu Lys 
                85                  90                  95      


Lys Ala Ala Ile Gly Asp Trp Phe Ala Thr Ala Gly Asn Phe Ala Val 
            100                 105                 110         


His Ile Glu Pro Met Lys Glu Leu Val Gln Gln Leu Ser Thr Gln Tyr 
        115                 120                 125             


Pro Ser Val Ser Gly Lys Trp Gly Ala Phe Gly Tyr Cys Trp Gly Gly 
    130                 135                 140                 


Lys Met Val Ala Leu Thr Ser Gly Glu Gly Thr Ile Phe Lys Thr Ser 
145                 150                 155                 160 


Gly Gln Thr His Pro Gly Met Leu Ser Ala Asp Asp Val Ser Lys Ile 
                165                 170                 175     


Asn Ile Pro His Ile Ile Leu Ala Ser Lys Asp Glu Asp Ala Thr Ala 
            180                 185                 190         


Val Ala Glu Cys Lys Lys Val Leu Glu Gly Pro Gly Lys Thr Gly Leu 
        195                 200                 205             


Val Lys Ser Tyr Pro Asp Gln Ile His Gly Trp Met Ala Ala Arg Ala 
    210                 215                 220                 


Asn Leu Lys Asp Glu Thr Val Arg Lys Ala Phe Glu Asp Gly Tyr Lys 
225                 230                 235                 240 


Thr Ala Ala Glu Phe Phe Glu Gln His Leu 
                245                 250 


<210>  190
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 189

<400>  190

Met Ser Gly His Asn Gly Ala Cys Leu Cys Leu Pro Val Ala Lys Val 
1               5                   10                  15      


Asp Asp Tyr Gln Ala Lys Gly Arg Tyr Glu Thr Val Leu Asp Thr Lys 
            20                  25                  30          


Thr Tyr Ile Thr Gly Pro Thr Asp Ala Lys Arg Ala Leu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Phe Gly Tyr Ser Pro Gln Leu Leu Gln Gly Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Ser Leu Asn Ala Leu Val Val Val Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gly Lys Val Ala Ser Glu Ser Trp Phe Pro Pro Thr Thr Glu Glu Lys 
                85                  90                  95      


Arg Ala Ala Ile Pro Asp Trp Phe Gln Thr Ala Gly Asn Phe Ala Val 
            100                 105                 110         


His Ile Glu Pro Met Lys Glu Leu Val Gln Gln Leu Ser Thr Gln Tyr 
        115                 120                 125             


Pro Ser Val Ser Gly Lys Trp Gly Ala Phe Gly Tyr Cys Trp Gly Gly 
    130                 135                 140                 


Lys Met Val Ala Leu Thr Ser Gly Glu Gly Thr Ile Phe Lys Thr Ser 
145                 150                 155                 160 


Gly Gln Thr His Pro Gly Met Leu Ser Ala Asp Asp Val Ser Lys Ile 
                165                 170                 175     


Asn Ile Pro His Ile Ile Leu Ala Ser Lys Asp Glu Asp Ala Thr Ala 
            180                 185                 190         


Val Ala Glu Cys Lys Lys Val Leu Gln Gly Pro Gly Lys Thr Gly Leu 
        195                 200                 205             


Val Tyr Ser Tyr Pro Asp Gln Arg His Gly Trp Met Ala Ala Arg Ala 
    210                 215                 220                 


Asn Thr Lys Asp Glu Thr Val Arg Ala Ala Phe Glu Asp Gly Tyr Lys 
225                 230                 235                 240 


Thr Ala Ala Glu Phe Phe Glu Gln His Leu 
                245                 250 


<210>  191
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 189

<400>  191

Met Ser Gly His Asn Lys Ala Cys Leu Cys Leu Pro Val Ala Val Val 
1               5                   10                  15      


Asp Asp Tyr Gln Ala Lys Gly Arg Tyr Glu Thr Val Leu Asp Thr Lys 
            20                  25                  30          


Thr Tyr Ile Thr Gly Pro Ser Asp Ala Ser Arg Ala Leu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Phe Gly Tyr Ser Pro Gln Leu Leu Gln Gly Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Ser Leu Asn Ala Leu Val Val Val Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gly Lys Val Tyr Ser Glu Ser Trp Phe Pro Ala Asp Thr Glu Glu Pro 
                85                  90                  95      


Lys Ala Ala Ile Gly Asp Leu Phe Lys Thr Lys Ala Asn Phe Ala Val 
            100                 105                 110         


His Ile Glu Pro Met Lys Glu Leu Val Gln Trp Leu Ser Gly Gln Tyr 
        115                 120                 125             


Pro Gly Val Ser Gly Lys Trp Gly Ala Phe Gly Tyr Cys Trp Gly Gly 
    130                 135                 140                 


Lys Met Val Ala Leu Thr Ser Gly Glu Gly Thr Ile Phe Lys Thr Ser 
145                 150                 155                 160 


Gly Gln Thr His Pro Gly Met Leu Ser Ala Asp Asp Val Ser Lys Ile 
                165                 170                 175     


Asn Ile Pro His Ile Ile Leu Ala Ser Lys Asp Glu Asp Ala Thr Ala 
            180                 185                 190         


Val Glu Glu Cys Lys Lys Val Leu Glu Gly Pro Gly Lys Thr Gly Leu 
        195                 200                 205             


Val Lys Ser Tyr Pro Asp Gln Pro His Gly Trp Met Ala Cys Arg Ala 
    210                 215                 220                 


Asn Leu Lys Asp Glu Thr Val Arg Lys Ala Phe Glu Asp Gly Tyr Lys 
225                 230                 235                 240 


Thr Ala Ala Glu Phe Phe Glu Gln His Leu 
                245                 250 


<210>  192
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 189

<400>  192

Met Ser Gly His Asn Lys Ala Cys Leu Cys Leu Pro Val Ala Val Val 
1               5                   10                  15      


Asp Asp Tyr Gln Ala Lys Gly Arg Tyr Glu Thr Val Leu Asp Thr Lys 
            20                  25                  30          


Thr Tyr Ile Thr Leu Pro Ser Gly Ala Ser Arg Ala Leu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Phe Gly Tyr Ser Pro Gln Leu Leu Gln Gly Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Ser Arg Asn Ala Leu Val Val Val Pro Asp Phe Phe Asn 
65                  70                  75                  80  


Gly Lys Val Lys Ser Glu Ser Trp Ile Pro Pro Gly Ser Glu Glu Lys 
                85                  90                  95      


Lys Lys Ala Ile Gly Asp Leu Phe Asp Thr Ala Gly Asn Phe Ala Val 
            100                 105                 110         


His Ile Glu Pro Met Lys Glu Leu Val Gln Gln Leu Ser Thr Gln Tyr 
        115                 120                 125             


Pro Ser Val Ser Gly Lys Trp Gly Ala Phe Gly Tyr Cys Trp Gly Gly 
    130                 135                 140                 


Lys Met Val Ala Leu Thr Ser Gly Glu Gly Thr Ile Phe Lys Thr Ser 
145                 150                 155                 160 


Gly Gln Thr His Pro Gly Gly Leu Ser Ile Asp Asp Val Ser Lys Ile 
                165                 170                 175     


Asn Ile Pro His Ile Ile Leu Ala Ser Lys Asp Glu Asp Ala Thr Ala 
            180                 185                 190         


Val Ala Glu Cys Lys Lys Val Leu Glu Gly Ala Gly Lys Thr Val Leu 
        195                 200                 205             


Val Lys Ser Tyr Pro Asp Gln Pro His Gly Trp Met Ala Ala Arg Ala 
    210                 215                 220                 


Asn Leu Lys Asp Arg Thr Val Arg Lys Ala Phe Glu Asp Gly Tyr Asn 
225                 230                 235                 240 


Thr Ala Ala Glu Phe Phe Glu Gln His Leu 
                245                 250 


<210>  193
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 189

<400>  193

Met Ser Gly His Asn Lys Ala Cys Leu Cys Leu Pro Val Ala Val Val 
1               5                   10                  15      


Asp Asp Tyr Gln Ala Lys Gly Arg Tyr Glu Thr Val Leu Asp Thr Lys 
            20                  25                  30          


Thr Tyr Ile Thr Gly Pro Ser Asp Ala Ala Arg Ala Leu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Phe Gly Tyr Ser Pro His Leu Leu Gln Gly Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Glu Leu Asn Ala Leu Val Val Val Pro Asp Phe Phe Gly 
65                  70                  75                  80  


Gly Lys Val Ser Ser Ile Ser Trp Tyr Pro Pro Asp Thr Glu Glu Lys 
                85                  90                  95      


Lys Ala Ala Ile Ser Asp Trp Phe Ala Ser Ala Gly Asn Phe Ala Lys 
            100                 105                 110         


His Thr Glu Pro Met Lys Glu Leu Val Gln Gln Leu Ser Thr Arg Tyr 
        115                 120                 125             


Pro Ser Val Ser Gly Lys Trp Gly Ala Phe Gly Tyr Cys Trp Gly Gly 
    130                 135                 140                 


Lys Met Val Ala Leu Thr Ser Gly Glu Gly Thr Arg Phe Lys Thr Ser 
145                 150                 155                 160 


Gly Gln Thr His Pro Gly Met Leu Ser Arg Asp Asp Val Gly Lys Ile 
                165                 170                 175     


Asn Ile Pro His Ile Ile Leu Ala Ser Lys Asp Glu Asp Ala Thr Ala 
            180                 185                 190         


Val Val Glu Cys Lys Lys Val Leu Thr Gly Pro Gly Lys Thr Gly Leu 
        195                 200                 205             


Val Lys Ser Tyr Pro Asp Gln Pro His Gly Trp Met Ala Ala Arg Pro 
    210                 215                 220                 


Asn Pro Lys Ala Ser Thr Val Arg Lys Ala Phe Glu Asp Gly Tyr Asp 
225                 230                 235                 240 


Thr Ala Ala Ala Phe Phe Glu Gln Arg Leu 
                245                 250 


<210>  194
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 189

<400>  194

Met Ser Gly His Asn Lys Ala Cys Leu Cys Gly Pro Val Ala Val Val 
1               5                   10                  15      


Asp Asp Tyr Gln Ala Pro Gly Arg Ala Glu Thr Val Leu Asp Thr Lys 
            20                  25                  30          


Thr Tyr Ile Thr Gln Pro Ala Asp Ala Arg Arg Ala Leu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Phe Gly Tyr Ser Pro Gln Leu Leu Glu Gly Ala Asp Ile 
    50                  55                  60                  


Leu Ala Ala Ser Leu Asn Ala Leu Val Val Val Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gly Lys Val Ala Thr Glu Val Trp Val Pro Ala Asp Thr Glu Glu Gln 
                85                  90                  95      


Val Ala Ala Ile Gly Asp Trp Phe Ala Pro Ala Gly Asn Pro Ala Gln 
            100                 105                 110         


Val Ile Glu Pro Met Lys Glu Leu Val Gln Gln Leu Ser Asn Gln Tyr 
        115                 120                 125             


Pro Ser Val Ser Gly Lys Trp Gly Ala Phe Gly Tyr Cys Trp Gly Gly 
    130                 135                 140                 


Lys Met Val Ala Leu Thr Ser Gly Pro Gly Ala Tyr Phe Lys Thr Ser 
145                 150                 155                 160 


Gly Gln Thr His Pro Gly Met Leu Ser Ala Asp Asp Val Ser Lys Ile 
                165                 170                 175     


Asn Ile Pro His Ile Ile Leu Ala Ser Lys Asp Glu Asp Ala Thr Ala 
            180                 185                 190         


Val Ala Glu Cys Lys Lys Val Leu Glu Gly Pro Gly Lys Thr Gly Leu 
        195                 200                 205             


Val Glu Ser Tyr Pro Asp Gln Ile His Gly Trp Met Ala Ala Arg Gly 
    210                 215                 220                 


Asn Asp Lys Asp Pro Thr Val Arg Lys Ala Phe Glu Asp Gly Tyr Lys 
225                 230                 235                 240 


Thr Ala Ala Glu Phe Phe Glu Gln His Leu 
                245                 250 


<210>  195
<211>  2240
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  195
atgaacctcg tcagtctctt tctcaccgtc gccttcatcc cctctgcatt ggcccagtcg       60

tactatccac ccgtaccggc cggcaccacc gtggtcaact cgacccagta tcccaatgcg      120

agcattgagt acaaagaggt gagatttcca tgccttctgg atctcgtagg tacttaaagt      180

tggtgtctat agaccacgat ctgcgagacc acccccggag tcaaggggta cagcggatat      240

gtccggctcc ccagcgatgt tgtgaacagc gtgaatggac cgcacacgtc caattacttc      300

ttctggttct tcgaggcgcg tcacgatccg gacaaggctc ccctggccat ctatctcgac      360

ggcggaccgg ggttgagctc gctgcagggg gctttcaccg agacgggacc ctgctatgtc      420

aacgaggact ccaacagcac ccgactcaat ccgtggtcgt ggaataacca tgtcaacatg      480

ctctacattg accagcccct gtccacgggc ttttcctatg atattctggt gaatggcacg      540

ttcgactcgc tacgcgacaa acagccggcc accgagcact cgatcaaccc tctggctgac      600

gaggacgagc ctgtggccaa caacacctat tttgttggga ccttctcggg gcagaacccc      660

ggtgagacgg ccaactctac cgccaacggc gcggtgggca tttggacctt tttgcaaact      720

tggctctccg agtacgcctg tcttcgaggg taactttcgc aacgacagct gacgtatggg      780

atcagatttc cggaatatcg gacgaaggat gatcgaatca gtctatgggg tgaagcggtg      840

agtgactgat ttggaagtct aattgcagac cagtgcggcg tctctgacgg ttatgcatat      900

aaacatgaag tttgccgggc aattcgctac catctacgcc gagtactttg aagtccaaaa      960

tgagcggatt cgaaatggca gccttcgacg cgattccaac tcgcccgaga gtccccggat     1020

catccccgtg gacaccgtcg ggctcatcaa cggttggata gacatgtttc gccaggccgc     1080

cggctaccta accctcccct tcaacaacac ctacggactg caggtggcca atgcgagcgt     1140

tcagcgtcag atcacggacg cgtactaccg gccgggcgga tgcgtggacc agacgcagaa     1200

atgccagacg gccgccgcag agtcagatcc gaagaatcgc gcgcacaacg cgacggtcaa     1260

tgagctctgc ttccagtccg cctacctctg cacgaccacc gtccgaggtc ccattgcggc     1320

gacacaggta tgttgcgagg agcaagaggt cacggcacag aactgactgg ggagcagtac     1380

aatacgttcg acatgggcca ttggaacccc gatccatttc ccccgagcta ttacattggc     1440

tatctcaacc aacgctgggt ccaggaggct ctgggagtcc ccctcaactt taccgcacac     1500

tcatcgttgg tcaccatgtg tatgtgtctc cccagcggtt atcgaaagct ctacacaagg     1560

ctcacaggcc agtagcattc ctcaaaagcg gcgcgtttgc cctcccctgg gcgcttcagg     1620

atctgggaaa gcttctcgat cgcggggtgc aggtgacgat gatgtacggt gatcgtgata     1680

tggacgtgag ctgtaagtat tccctttctt tgtgcaatga attggtaatt gatgggagtc     1740

aatagggatc ggtggtgagg aagtcagcct ggccatcgat cattcctcgg ccgcggaatt     1800

cgccgccagt ggatatgaga gtatctccgt caatgcaggc tatatcggcg gcgtaacacg     1860

gcaatatggg cgactgtcct tttcccgcgt ctttgaagca gcgaatagag gtattcattc     1920

ccaccgtgct atctcatact gttcactatg ctgatggcga tggcggccaa atcgcagtgc     1980

cctcgtacca accggaaacc gcctatcaaa tcttcatgcg cgccatcttt gggaaggaca     2040

tcgccaccgg gtcgacagtc gtcgatgccc gctatgcctc gaccgggcca tcatccagcg     2100

ggcatatccg caacggactg cccgtggccc cgccccccga gtgctatatc tgggccccgg     2160

cgacatgcac gccggcgcag ctgaagtcac tcggggacgg gtcggcggtc gtccgtgatt     2220

atattgtggt cgagtggtga                                                 2240


<210>  196
<211>  596
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  196

Met Asn Leu Val Ser Leu Phe Leu Thr Val Ala Phe Ile Pro Ser Ala 
1               5                   10                  15      


Leu Ala Gln Ser Tyr Tyr Pro Pro Val Pro Ala Gly Thr Thr Val Val 
            20                  25                  30          


Asn Ser Thr Gln Tyr Pro Asn Ala Ser Ile Glu Tyr Lys Glu Thr Thr 
        35                  40                  45              


Ile Cys Glu Thr Thr Pro Gly Val Lys Gly Tyr Ser Gly Tyr Val Arg 
    50                  55                  60                  


Leu Pro Ser Asp Val Val Asn Ser Val Asn Gly Pro His Thr Ser Asn 
65                  70                  75                  80  


Tyr Phe Phe Trp Phe Phe Glu Ala Arg His Asp Pro Asp Lys Ala Pro 
                85                  90                  95      


Leu Ala Ile Tyr Leu Asp Gly Gly Pro Gly Leu Ser Ser Leu Gln Gly 
            100                 105                 110         


Ala Phe Thr Glu Thr Gly Pro Cys Tyr Val Asn Glu Asp Ser Asn Ser 
        115                 120                 125             


Thr Arg Leu Asn Pro Trp Ser Trp Asn Asn His Val Asn Met Leu Tyr 
    130                 135                 140                 


Ile Asp Gln Pro Leu Ser Thr Gly Phe Ser Tyr Asp Ile Leu Val Asn 
145                 150                 155                 160 


Gly Thr Phe Asp Ser Leu Arg Asp Lys Gln Pro Ala Thr Glu His Ser 
                165                 170                 175     


Ile Asn Pro Leu Ala Asp Glu Asp Glu Pro Val Ala Asn Asn Thr Tyr 
            180                 185                 190         


Phe Val Gly Thr Phe Ser Gly Gln Asn Pro Gly Glu Thr Ala Asn Ser 
        195                 200                 205             


Thr Ala Asn Gly Ala Val Gly Ile Trp Thr Phe Leu Gln Thr Trp Leu 
    210                 215                 220                 


Ser Glu Tyr Ala Cys Leu Arg Gly Phe Pro Glu Tyr Arg Thr Lys Asp 
225                 230                 235                 240 


Asp Arg Ile Ser Leu Trp Gly Glu Ala Thr Ser Ala Ala Ser Leu Thr 
                245                 250                 255     


Val Met His Ile Asn Met Lys Phe Ala Gly Gln Phe Ala Thr Ile Tyr 
            260                 265                 270         


Ala Glu Tyr Phe Glu Val Gln Asn Glu Arg Ile Arg Asn Gly Ser Leu 
        275                 280                 285             


Arg Arg Asp Ser Asn Ser Pro Glu Ser Pro Arg Ile Ile Pro Val Asp 
    290                 295                 300                 


Thr Val Gly Leu Ile Asn Gly Trp Ile Asp Met Phe Arg Gln Ala Ala 
305                 310                 315                 320 


Gly Tyr Leu Thr Leu Pro Phe Asn Asn Thr Tyr Gly Leu Gln Val Ala 
                325                 330                 335     


Asn Ala Ser Val Gln Arg Gln Ile Thr Asp Ala Tyr Tyr Arg Pro Gly 
            340                 345                 350         


Gly Cys Val Asp Gln Thr Gln Lys Cys Gln Thr Ala Ala Ala Glu Ser 
        355                 360                 365             


Asp Pro Lys Asn Arg Ala His Asn Ala Thr Val Asn Glu Leu Cys Phe 
    370                 375                 380                 


Gln Ser Ala Tyr Leu Cys Thr Thr Thr Val Arg Gly Pro Ile Ala Ala 
385                 390                 395                 400 


Thr Gln Arg Leu Ser Lys Ala Leu His Lys Ala His Arg Pro Val Ala 
                405                 410                 415     


Phe Leu Lys Ser Gly Ala Phe Ala Leu Pro Trp Ala Leu Gln Asp Leu 
            420                 425                 430         


Gly Lys Leu Leu Asp Arg Gly Val Gln Val Thr Met Met Tyr Gly Asp 
        435                 440                 445             


Arg Asp Met Asp Val Ser Trp Ile Gly Gly Glu Glu Val Ser Leu Ala 
    450                 455                 460                 


Ile Asp His Ser Ser Ala Ala Glu Phe Ala Ala Ser Gly Tyr Glu Ser 
465                 470                 475                 480 


Ile Ser Val Asn Ala Gly Tyr Ile Gly Gly Val Thr Arg Gln Tyr Gly 
                485                 490                 495     


Arg Leu Ser Phe Ser Arg Val Phe Glu Ala Ala Asn Arg Val Pro Ser 
            500                 505                 510         


Tyr Gln Pro Glu Thr Ala Tyr Gln Ile Phe Met Arg Ala Ile Phe Gly 
        515                 520                 525             


Lys Asp Ile Ala Thr Gly Ser Thr Val Val Asp Ala Arg Tyr Ala Ser 
    530                 535                 540                 


Thr Gly Pro Ser Ser Ser Gly His Ile Arg Asn Gly Leu Pro Val Ala 
545                 550                 555                 560 


Pro Pro Pro Glu Cys Tyr Ile Trp Ala Pro Ala Thr Cys Thr Pro Ala 
                565                 570                 575     


Gln Leu Lys Ser Leu Gly Asp Gly Ser Ala Val Val Arg Asp Tyr Ile 
            580                 585                 590         


Val Val Glu Trp 
        595     


<210>  197
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 196

<400>  197

Met Asn Leu Val Ser Leu Phe Leu Thr Val Ala Phe Ile Pro Ser Ala 
1               5                   10                  15      


Leu Ala Gln Ser Tyr Tyr Pro Pro Leu Pro Ala Gly Thr Thr Val Val 
            20                  25                  30          


Asn Ser Lys Gln Tyr Pro Asn Ala Ser Ile Glu Tyr Lys Glu Thr Thr 
        35                  40                  45              


Ile Cys Glu Thr Thr Pro Gly Val Lys Gly Tyr Ser Gly Tyr Val Arg 
    50                  55                  60                  


Leu Pro Ser Asp Ala Val Asn Ser Val Asn Gly Pro Ser Thr Ser Asn 
65                  70                  75                  80  


Tyr Phe Phe Trp Phe Phe Glu Ala Arg His Asp Pro Asp Lys Ala Pro 
                85                  90                  95      


Leu Ala Ile Tyr Leu Asp Gly Gly Pro Gly Leu Ser Ser Leu Gln Gly 
            100                 105                 110         


Ala Phe Thr Glu Thr Gly Pro Cys Tyr Val Asn Glu Asp Ser Asn Gln 
        115                 120                 125             


Thr Arg Leu Asn Pro Trp Ser Trp Asn Asn His Val Asn Met Leu Tyr 
    130                 135                 140                 


Ile Asp Gln Pro Leu Ser Thr Gly Phe Ser Tyr Asp Ile Leu Val Asn 
145                 150                 155                 160 


Gly Thr Phe Asp Ser Leu Arg Asp Lys Gln Pro Ala Thr Glu His Ser 
                165                 170                 175     


Ile Asn Pro Leu Ala Asp Glu Asp Glu Pro Val Ala Asn Asn Thr Tyr 
            180                 185                 190         


Phe Val Gly Thr Phe Ser Gly Gln Asn Pro Ser Asn Thr Ala Asn Ser 
        195                 200                 205             


Thr Asp Asn Gly Ala Val Gly Ile Trp Thr Phe Leu Gln Thr Trp Leu 
    210                 215                 220                 


Asn Glu Tyr Ala Cys Leu Arg Gly Phe Pro Glu Tyr Arg Leu Lys Asp 
225                 230                 235                 240 


Asp Arg Ile Ser Leu Trp Gly Glu Ala Thr Ser Ala Ala Ser Leu Thr 
                245                 250                 255     


Val Met His Ile Asn Met Lys Phe Ala Gly Gln Phe Ala Thr Ile Tyr 
            260                 265                 270         


Ala Glu Glu Phe Leu Val Gln Asn Glu Gly Ile Thr Asn Gly Ser Leu 
        275                 280                 285             


Arg Arg Asp Ser Asn Ser Ala Glu Ser Pro Arg Ile Ile Pro Val Asp 
    290                 295                 300                 


Thr Val Gly Leu Ile Asn Gly Trp Ile Asp Met Phe Arg Gln Ala Ala 
305                 310                 315                 320 


Gly Tyr Leu Thr Leu Pro Phe Ser Asn Thr Tyr Gly Leu Gln Val Ala 
                325                 330                 335     


Asn Ala Ser Val Gln Arg Gln Ile Thr Asp Ala Tyr Asp Arg Asp Gly 
            340                 345                 350         


Gly Cys Lys Asp Leu Thr Gln Ile Cys Glu Thr Ile Ala Met Glu Ser 
        355                 360                 365             


Asp Pro Lys Asn Leu Ala His Asn Ala Thr Thr Asn Glu Ala Cys Phe 
    370                 375                 380                 


Gln Ser Ala Tyr Leu Cys Thr Thr Thr Val Arg Gly Pro Ile Ala Ala 
385                 390                 395                 400 


Thr Gln Arg Leu Val Lys Ala Leu His Lys Ala His Arg Pro Val Ala 
                405                 410                 415     


Phe Leu Lys Ser Gly Ala Phe Ala Leu Pro Trp Ala Leu Gln Asp Leu 
            420                 425                 430         


Gly Lys Leu Leu Asp Ser Gly Val Gln Val Thr Met Met Tyr Gly Asp 
        435                 440                 445             


Arg Asp Met Asp Val Ser Trp Ile Gly Gly Glu Glu Val Ser Leu Ala 
    450                 455                 460                 


Ile Asp His Ser Ser Ala Ala Glu Phe Ala Ala Ser Gly Tyr Glu Ser 
465                 470                 475                 480 


Ile Ser Val Asn Ala Gly Tyr Ile Gly Gly Val Thr Arg Gln Tyr Gly 
                485                 490                 495     


Arg Leu Ser Phe Ser Arg Val Phe Glu Ala Ala Asn Arg Val Pro Ser 
            500                 505                 510         


Tyr Gln Pro Glu Thr Ala Tyr Gln Ile Phe Met Arg Ala Ile Phe Gly 
        515                 520                 525             


Lys Asp Ile Ala Thr Gly Ser Thr Val Val Asp Ala Arg Tyr Ala Ser 
    530                 535                 540                 


Ala Gly Pro Ser Ser Ser Gly His Ile Arg Asn Gly Leu Pro Val Ala 
545                 550                 555                 560 


Pro Pro Pro Glu Cys Tyr Ile Trp Ala Pro Ala Thr Cys Thr Pro Ala 
                565                 570                 575     


Gln Leu Lys Ser Leu Gly Asp Gly Ser Ala Val Val Arg Asp Tyr Ile 
            580                 585                 590         


Val Val Glu Trp 
        595     


<210>  198
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 196

<400>  198

Met Asn Leu Val Ser Leu Phe Leu Thr Val Ala Phe Ile Pro Ser Ala 
1               5                   10                  15      


Leu Ala Gln Ser Tyr Tyr Pro Pro Val Pro Ala Gly Thr Thr Val Val 
            20                  25                  30          


Asn Ser Thr Gln Tyr Pro Asn Ala Ser Ile Glu Tyr Lys Glu Thr Thr 
        35                  40                  45              


Ile Cys Glu Thr Thr Pro Gly Val Lys Gly Tyr Ser Gly Tyr Val Arg 
    50                  55                  60                  


Leu Pro Ser Asp Val Val Asn Ser Val Asn Gly Pro His Thr Ser Asn 
65                  70                  75                  80  


Tyr Phe Phe Trp Phe Phe Glu Ala Arg His Asp Pro Asp Lys Ala Pro 
                85                  90                  95      


Leu Ala Ile Tyr Leu Asp Gly Gly Pro Gly Leu Ser Ser Leu Gln Gly 
            100                 105                 110         


Ala Phe Glu Glu Thr Gly Pro Cys Tyr Val Val Glu Asp Ser Asn Thr 
        115                 120                 125             


Thr Arg Leu Asn Pro Trp Ser Trp Asn Asn His Val Asn Met Leu Tyr 
    130                 135                 140                 


Ile Asp Gln Pro Leu Ser Thr Gly Phe Ser Tyr Asp Ile Leu Ser Asn 
145                 150                 155                 160 


Gly Thr Phe Asp Ser Leu Arg Asp Lys Gln Pro Ala Thr Glu His Ser 
                165                 170                 175     


Leu Phe Ile Leu Ala Asp Glu Asp Glu Pro Val Ala Asn Asn Thr Tyr 
            180                 185                 190         


Phe Val Gly Thr Phe Ser Gly Gln Asn Pro Gly Glu Thr Ala Asn Ser 
        195                 200                 205             


Thr Ala Asp Gly Ala Val Gly Ile Trp Thr Phe Leu Gln Thr Trp Leu 
    210                 215                 220                 


Ser Glu Tyr Ala Cys Leu Arg Gly Phe Pro Glu Tyr Arg Thr Lys Asp 
225                 230                 235                 240 


Asp Arg Ile Ser Leu Trp Gly Glu Ala Thr Ser Ala Ala Ser Leu Thr 
                245                 250                 255     


Val Met His Ile Asn Met Lys Phe Ala Gly Gln Phe Ala Thr Ile Tyr 
            260                 265                 270         


Ala Glu Phe Phe Glu Val Gln Asn Glu Arg Ile Arg Asn Gly Ser Leu 
        275                 280                 285             


Arg Arg Asp Ser Asn Ser Pro Ser Ser Pro Arg Ile Ile Pro Val Asp 
    290                 295                 300                 


Thr Val Gly Leu Ile Asn Gly Trp Ile Asp Met Phe Arg Gln Tyr Ala 
305                 310                 315                 320 


Gly Tyr Leu Thr Leu Pro Phe Asn Asn Thr Tyr Gly His Gln Val Ala 
                325                 330                 335     


Asn Ala Ser Val Gln Arg Gln Ile Thr Asp Ala Tyr Asp Arg Pro Gly 
            340                 345                 350         


Gly Cys Val Asp Gln Thr Gln Lys Cys Gln His Ala Ala Ala Glu Ser 
        355                 360                 365             


Asp Pro Lys Asn Arg Ala His Asn Ala Thr Val Ile Glu Tyr Cys Ala 
    370                 375                 380                 


Lys Ser Ala Tyr Leu Cys Asp Thr Thr Val Arg Gly Leu Ile Ala Ala 
385                 390                 395                 400 


Thr Gln Tyr Leu Ser Lys Ala Leu His Lys Ala His Arg Pro Val Ala 
                405                 410                 415     


Phe Leu Lys Ser Gly Ala Ser Ala Leu Pro Trp Phe Leu Gly Asp Leu 
            420                 425                 430         


Gly Gln Leu Leu Asp Arg Gly Val Gln Val Thr Met Met Tyr Gly Asp 
        435                 440                 445             


Arg Asp Met Asp Val Ser Trp Ile Gly Gly Glu Glu Val Ser Leu Ala 
    450                 455                 460                 


Ile Asp His Ser Ser Ala Ala Glu Phe Ala Ala Ser Gly Tyr Lys Ser 
465                 470                 475                 480 


Ile Ser Val Asn Ala Gly Tyr Ile Gly Gly Thr Thr Arg Gln Tyr Gly 
                485                 490                 495     


Arg Leu Ser Phe Ser Arg Val Phe Glu Ala Ala Asn Arg Val Pro Ser 
            500                 505                 510         


Tyr Gln Pro Pro Thr Ala Tyr Lys Ile Phe Met Arg Ala Ile Phe Gly 
        515                 520                 525             


Lys Asp Ile Ala Thr Gly Ser Thr Val Val Asp Ala Arg Tyr Ala Ser 
    530                 535                 540                 


Thr Gly Pro Ser Ser Ser Gly His Ile Arg Asn Gly Leu Pro Val Met 
545                 550                 555                 560 


Pro Pro Pro Glu Cys Tyr Ile Trp Ala Pro Ala Thr Cys Thr Pro Ala 
                565                 570                 575     


Gln Leu Lys Ser Leu Gly Asp Gly Ser Ala Val Val Arg Asp Tyr Ile 
            580                 585                 590         


Val Val Glu Trp 
        595     


<210>  199
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 196

<400>  199

Met Asn Leu Val Ser Leu Phe Leu Thr Val Ala Phe Ile Pro Ser Ala 
1               5                   10                  15      


Leu Ala Gln Ser Tyr Tyr Pro Pro Val Pro Ala Gly Thr Thr Val Val 
            20                  25                  30          


Asn Ser Thr Gln Tyr Pro Asn Ala Ser Ile Glu Tyr Lys Glu Thr Thr 
        35                  40                  45              


Ile Cys Glu Thr Thr Pro Asp Val Lys Gly Tyr Ser Gly Tyr Val Arg 
    50                  55                  60                  


Leu Pro Ser Asp Ala Val Asn Ser Val Asn Gly Ser His Thr Ser Asn 
65                  70                  75                  80  


Tyr Phe Phe Trp Phe Phe Glu Ala Arg Lys Asp Pro Asp Lys Ala Pro 
                85                  90                  95      


Leu Ala Ile Tyr Leu Asp Gly Gly Pro Gly Leu Ser Ser Leu Gln Gly 
            100                 105                 110         


Ala Phe Thr Glu Thr Gly Pro Cys Tyr Val Asn Lys Asp Ser Asn Ser 
        115                 120                 125             


Thr Arg Leu Asn Pro Trp Ser Trp Asn Asn His Val Asn Met Leu Tyr 
    130                 135                 140                 


Ile Asp Gln Pro Leu Ser Thr Gly Phe Ser Tyr Asp Ile Gln Thr Asn 
145                 150                 155                 160 


Thr Thr Val Asp Ser Val Arg Asp Lys Gln Pro Ala Thr Glu His Ser 
                165                 170                 175     


Ile Asn Pro Leu Ala Asp Glu Asp Glu Pro Val Ala Asn Leu Thr Tyr 
            180                 185                 190         


His Val Gly Thr Phe Ser Gly Gln Asn Pro Gly Thr Thr Ala Asn Ser 
        195                 200                 205             


Thr Ala Asn Gly Ala Val Gly Ile Trp Thr Phe Leu Gln Asn Trp Leu 
    210                 215                 220                 


Ser Glu Tyr Ala Cys Leu Arg Gly Phe Pro Glu Tyr Arg Thr Lys Asp 
225                 230                 235                 240 


Asp Arg Ile Ser Leu Trp Gly Glu Ala Thr Ser Ala Ala Ser Leu Thr 
                245                 250                 255     


Val Met His Ile Asn Met Lys Phe Ala Gly Gln Phe Ala Thr Ile Tyr 
            260                 265                 270         


Ala Glu Glu Phe Glu Val Ala Asn Glu Arg Ile Arg Asn Gly Ser Leu 
        275                 280                 285             


Arg Arg Asp Ser Asn Ser Pro Glu Ser Ala Ala Ile Ile Pro Val Asp 
    290                 295                 300                 


Thr Val Gly Leu Ile Asn Gly Trp Ile Asp Met Phe Arg Gln Tyr Ala 
305                 310                 315                 320 


Gly Tyr Leu Thr Leu Pro Phe Asn Asn Thr Tyr Gly Leu Gln Val Ala 
                325                 330                 335     


Asn Ala Ser Val Gln Asn Gln Ile Thr Asp Ala Tyr Tyr Glu Pro Gly 
            340                 345                 350         


Ser Cys Val Asp His Thr Gln Lys Cys Gln Thr Ala Phe Gln Glu Ser 
        355                 360                 365             


Asp Pro Lys Asn Arg Ala His Asn Ala Asp Val Asp Asp Leu Cys Phe 
    370                 375                 380                 


Gln Ser Ala Tyr Gly Cys Thr Thr Thr Val Arg Gly Ile Ile Ala Ala 
385                 390                 395                 400 


Thr Gln Arg Leu Ser Phe Ala Leu His Lys Ala His Arg Pro Val Ala 
                405                 410                 415     


Phe Leu Lys Ser Gly Ala Trp Ala Leu Pro Trp Trp Leu Pro Asp Leu 
            420                 425                 430         


Gly Glu Leu Leu Asp Arg Gly Val Gln Val Thr Met Met Tyr Gly Asp 
        435                 440                 445             


Arg Asp Met Asp Val Ser Trp Ile Gly Gly Glu Glu Val Ser Leu Ala 
    450                 455                 460                 


Ile Asp His Ser Ser Val Ala Gly Phe Arg Ala Ser Gly Tyr Glu Ser 
465                 470                 475                 480 


Ile Tyr Val Asn Ala Gly Tyr Ile Gly Gly Val Thr Arg Ser Tyr Gly 
                485                 490                 495     


Arg Leu Ser Phe Ser Arg Val Phe Glu Ala Ala Asn Arg Val Pro Ser 
            500                 505                 510         


Tyr Gln Pro Glu Ala Ala Tyr Gln Ile Phe Met Arg Ala Ile Phe Gly 
        515                 520                 525             


Lys Asp Ile Ala Thr Gly Ser Thr Val Val Asp Ala Arg Tyr Ala Ser 
    530                 535                 540                 


Thr Gly Pro Ser Ser Ser Gly His Ile Arg Asn Gly Leu Pro Val Ala 
545                 550                 555                 560 


Pro Pro Pro Glu Cys Tyr Ile Trp Ala Pro Ala Thr Cys Thr Pro Ala 
                565                 570                 575     


Gln Leu Lys Ser Leu Arg Asp Gly Ser Ala Val Val Arg Asp Tyr Ile 
            580                 585                 590         


Val Val Glu Trp 
        595     


<210>  200
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 196

<400>  200

Met Asn Leu Val Ser Leu Phe Leu Thr Val Ala Phe Ile Pro Ser Ala 
1               5                   10                  15      


Leu Ala Gln Ser Tyr Tyr Pro Pro Val Pro Ala Gly Thr Thr Val Val 
            20                  25                  30          


Asn Ser Thr Ala Tyr Pro Asn Tyr Ser Ile Glu Tyr Lys Glu Thr Thr 
        35                  40                  45              


Ile Cys Glu Thr Thr Pro Gly Val Lys Gly Tyr Ser Gly Tyr Val Arg 
    50                  55                  60                  


Leu Pro Ser Asp Val Val Asn Ser Val Asn Gly Pro Tyr Thr Ser Asn 
65                  70                  75                  80  


Tyr Phe Phe Trp Phe Phe Glu Ala Arg Ala Asp Pro Ala Lys Ala Pro 
                85                  90                  95      


Leu Ala Ile Tyr Leu Asp Gly Gly Pro Gly Leu Ser Ser Leu Gln Gly 
            100                 105                 110         


Ala Phe Thr Glu Thr Gly Pro Cys Gln Val Asn Glu Asp Ser Asn Val 
        115                 120                 125             


Thr Arg Leu Asn Pro Trp Ser Trp Asn Asn His Val Asn Met Leu Tyr 
    130                 135                 140                 


Ile Asp Gln Pro Leu Ser Thr Gly Phe Ser Tyr Asp Asn Asn Ala Asn 
145                 150                 155                 160 


Thr Thr His Asp Ser Leu Lys Asp Val Gln Pro Ala Thr Glu His Ser 
                165                 170                 175     


Phe Asp Pro Leu Ala Asp Glu Asp Glu Pro Val Ala Asn Asn Thr Tyr 
            180                 185                 190         


Phe Val Gly Thr Phe Ser Gly Gln Asn Pro Glu Glu Thr Ala Asn Ser 
        195                 200                 205             


Thr Ala Asn Gly Ala Gln Gly Ile Trp Thr Phe Leu Gln Gly Trp Leu 
    210                 215                 220                 


Ala Arg Tyr Ala Cys Leu Arg Gly Phe Pro Glu Tyr Ser Pro Lys Asp 
225                 230                 235                 240 


Asp Arg Ile Ser Leu Trp Gly Glu Ala Thr Ser Ala Ala Ser Leu Thr 
                245                 250                 255     


Val Met His Ile Asn Met Lys Phe Ala Gly Gln Phe Ala Thr Ile Tyr 
            260                 265                 270         


Ala Ala Tyr Phe Glu Val Gln Asn Lys Ala Ile Gly Asn Gly Val Leu 
        275                 280                 285             


Arg Arg Asp Ser Asn Ser Ser Asn Ser Pro Arg Ile Ile Pro Val Asp 
    290                 295                 300                 


Thr Val Gly Leu Ile Asn Gly Trp Ile Asp Met Phe Arg Gln Tyr Leu 
305                 310                 315                 320 


Gly Tyr Pro Thr Leu Pro Tyr Asn Asn Thr Tyr Ser Leu Gln Val Ala 
                325                 330                 335     


Asn Ala Ser Val Gln Arg Gln Ile Thr Asp Ala Tyr Glu Arg Glu Gly 
            340                 345                 350         


Gly Cys Val Asp Ser Thr Asp Lys Cys Gln Asp Ala Ala Ala Glu Ser 
        355                 360                 365             


Phe Pro Lys Asn Arg Ala Met Ile Ala Thr Val Asn Glu Asn Cys Phe 
    370                 375                 380                 


Gln Ser Ala Phe Tyr Cys Thr Thr Thr Phe Phe Gly Pro Ile Ala Ala 
385                 390                 395                 400 


Thr Gln Arg Leu Ser Lys Ala Leu His Lys Ala His Arg Pro Val Ala 
                405                 410                 415     


Phe Leu Lys Ser Gly Ala Tyr Val Phe Pro Trp Ala Leu Ser Asp Leu 
            420                 425                 430         


Gly Lys Leu Leu Asp Arg Gly Val Gln Val Thr Met Met Tyr Gly Asp 
        435                 440                 445             


Arg Asp Met Asp Val Ser Trp Ile Gly Gly Glu Leu Val Ser Leu Ala 
    450                 455                 460                 


Ile Asp His Thr Ser Ala Ala Glu Phe Ala Ala Ser Gly Arg Ala Ser 
465                 470                 475                 480 


Ile Ser Val Asn Ala Gly Tyr Ile Gly Gly Val Thr Arg Gly Tyr Gly 
                485                 490                 495     


Arg Leu Ser Phe Ser Arg Val Phe Glu Ala Ala Asn Arg Val Pro Ser 
            500                 505                 510         


Tyr Gln Pro Gln Ala Ala Tyr Gln Ile Phe Met Arg Ala Ile Phe Gly 
        515                 520                 525             


Lys Asp Ile Ala Thr Gly Asn Thr Val Val Asp Ala Arg Tyr Ala Ser 
    530                 535                 540                 


Thr Gly Pro Ser Ser Ser Gly His Ile Arg Asn Gly Leu Pro Val Ala 
545                 550                 555                 560 


Pro Pro Pro Glu Cys Tyr Ile Trp Ala Pro Ala Thr Cys Thr Pro Ala 
                565                 570                 575     


Gln Leu Lys Ser Leu Gly Asp Gly Ser Ala Val Val Arg Asp Tyr Ile 
            580                 585                 590         


Val Val Glu Trp 
        595     


<210>  201
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 196

<400>  201

Met Asn Leu Val Ser Leu Phe Leu Thr Val Ala Phe Ile Pro Ser Ala 
1               5                   10                  15      


Leu Ala Gln Ser Tyr Tyr Pro Pro Val Pro Ala Gly Thr Thr Val Val 
            20                  25                  30          


Asn Ser Thr Thr Tyr Pro Asn Ala Ser Ile Glu Tyr Lys Glu Thr Thr 
        35                  40                  45              


Ile Cys Glu Thr Thr Pro Gly Val Lys Gly Tyr Ser Gly Tyr Val Arg 
    50                  55                  60                  


Leu Pro Ser Asp Val Val Asn Ser Val Asn Gly His His Thr Ser Asn 
65                  70                  75                  80  


Tyr Phe Phe Trp Phe Phe Glu Ala Arg His Asp Pro Lys Lys Ala Pro 
                85                  90                  95      


Leu Ala Ile Tyr Leu Asp Gly Gly Pro Gly Leu Ser Ser Leu Thr Gly 
            100                 105                 110         


Ala Phe Thr Glu Thr Gly Pro Cys Tyr Val Asn Glu Asp Ser Asn Leu 
        115                 120                 125             


Thr Arg Leu Asn Pro Trp Ser Trp Asn Asn His Val Asn Met Leu Tyr 
    130                 135                 140                 


Ile Asp Gln Pro Leu Ser Thr Gly Phe Ser Tyr Asp Ile Leu Val Asn 
145                 150                 155                 160 


Gly Thr Phe Asp Ser Leu Arg Asp Leu Gln Pro Ala Thr Glu His Ser 
                165                 170                 175     


Ile Asn Cys Leu Ala Asp Glu Asp Glu Pro Val Ala Asn Phe Thr Tyr 
            180                 185                 190         


Leu Val Gly Thr Phe Ser Gly Gln Asn Thr Gly Gln Thr Ala Asn Ser 
        195                 200                 205             


Thr Ala Asn Gly Ala Val Gly Ile Trp Thr Phe Leu Gln Gly Trp Leu 
    210                 215                 220                 


Ser Glu Tyr Ala Cys Leu Arg Gly Phe Pro Glu Tyr Arg Thr Lys Asp 
225                 230                 235                 240 


Asp Arg Ile Ser Leu Trp Gly Glu Ala Thr Ser Ala Ala Ser Leu Thr 
                245                 250                 255     


Val Met His Ile Asn Met Lys Phe Ala Gly Gln Phe Ala Thr Ser Tyr 
            260                 265                 270         


Ala Gln Tyr Phe Glu Val Gln Asn Lys Arg Ile Arg Asn Gly Gly Gln 
        275                 280                 285             


Arg Arg Asp Ser Asn Ser Lys Glu Ser Pro Arg Ile Ile Pro Val Asp 
    290                 295                 300                 


Thr Val Gly Leu Ile Asn Gly Trp Ile Asp Met Thr Arg Gln Leu Ala 
305                 310                 315                 320 


Gly Tyr Ser Thr Leu Pro Phe Asn Asn Thr Tyr Gly Leu Gln Val Ala 
                325                 330                 335     


Asn Ala Ser Val Gln Arg Asp Ile Thr Lys Ala Tyr Gln Arg Pro Gly 
            340                 345                 350         


Val Cys Val Asp Gln Thr Gln Ser Cys Gln Thr Ala Met Ala Glu Ser 
        355                 360                 365             


Phe Phe Glu Ile Arg Ala His Trp Val Thr Tyr Lys Leu Ala Cys Phe 
    370                 375                 380                 


Gln Ser Ala Leu Leu Cys Tyr Thr Thr Val Arg Gly Pro Ile Ala Tyr 
385                 390                 395                 400 


Thr Gln Ile Leu Ser Lys Ala Leu His Lys Ala Thr Arg Pro Arg Ala 
                405                 410                 415     


Phe Lys Lys Ser Gly Ala Gly Ala Ala Pro Trp Met Ile Arg Asp Leu 
            420                 425                 430         


Ala Lys Leu Leu Asp Ala Gly Val Gln Val Thr Met Met Tyr Gly Asp 
        435                 440                 445             


Arg Asp Met Asp Val Ser Trp Ile Gly Gly Glu Gln Val Ser Leu Ala 
    450                 455                 460                 


Ile Asp His Ser Ser Val Asn Val Phe Ala Lys Ser Gly Ile Glu Ser 
465                 470                 475                 480 


Ile Ser Val Asn Ala Gly Tyr Ile Gly Gly Phe Thr Arg Gln Tyr Gly 
                485                 490                 495     


Arg Leu Ser Phe Ser Arg Val Phe Glu Ala Ala Asn Arg Val Pro Ser 
            500                 505                 510         


Tyr Gln Pro Glu Thr Ala Tyr Gln Ile Phe Asn Arg Ala Ile Phe Gly 
        515                 520                 525             


Lys Asp Ile Ala Thr Gly Ser Thr Val Val Asp Ala Arg Tyr Ala Ser 
    530                 535                 540                 


Ala Gly Pro Ser Ser Ser Gly His Ile Arg Asn Gly Leu Pro Val Ala 
545                 550                 555                 560 


Pro Pro Pro Glu Cys Tyr Ile Trp Ala Pro Ala Thr Cys Thr Pro Ala 
                565                 570                 575     


Gln Leu Lys Ser Leu Gly Asp Gly Ser Ala Val Val Arg Asp Tyr Ile 
            580                 585                 590         


Val Val Glu Trp 
        595     


<210>  202
<211>  1131
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  202
atgcatttca atcttctcct cgtcttgacc gtcctcctcc gccaggctac ggcactcgtc       60

ctgccgccgt ccaacagcac ctccaattcg accggcaaat tctccgcccg caccgtcttc      120

cagttccccc agggatactg gctggagaat ctggccgtcc ggggcaatgg ccaggtcctc      180

gcaaccacct acatgccgtc ggccggcctg tatctcatcg accccactcc caatgccagc      240

tatcccgcgg tcctcgtcca ccagttcgag aactcgacct cggccctggg catcgtggag      300

gcggagggga cagagcccga caccttctat ctggcgacgc tgaacttctc cgccgcggac      360

ggcttcgtcc cccgcaccag ccaggtctgg cgagtggaca tgtcctcgtt ccactactca      420

ccccagaccg ggcaggtctc cgggaaggcg gccgtctcgc atgttacgac gctgtcgtcg      480

gtgggcatgg ccaacggtat gaccctgctg gctccggact cgtcgcacat cctgatcgcg      540

gactcccttc ggggcgccat ctgggacctg gacaccgcga cgggccacta tggcctctcg      600

tcgtccttcc ccgccatgcg gtccgacaat ccggcgcgcc gcttcctcgg gatcgacgga      660

gtcaaggtgc accagggcag cctgtatttc aacaatgcgg gtgaattcac cctcgcccgc      720

atgcccatcc acagcgatgg catcgccaag ggggagccgg tcgtcctggc cacggacctc      780

tacagcgatg ggttctgtct gtacgacgcc gacacggtgc tggtgacgat gaacatcgac      840

aacggcctcg ccgcgctgga cctggagagc catcgccggt ggatggtggc cggcaacatg      900

cccgacgggg tctttacgac tccaacgtcg gtcgagctgg gccgcgggga ggacgcgggc      960

aaactcgcct acgtgaccat gggaggcacc tacgtggcga ccggtgccga ggatctcgtc     1020

gggggcagct tagtcgtggt ggacctgaag tcggccacga ccgatccgaa aggaacggga     1080

agaggtgggc tgctggtgca ggagacagag acgatttggt tggagctgta g              1131


<210>  203
<211>  376
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  203

Met His Phe Asn Leu Leu Leu Val Leu Thr Val Leu Leu Arg Gln Ala 
1               5                   10                  15      


Thr Ala Leu Val Leu Pro Pro Ser Asn Ser Thr Ser Asn Ser Thr Gly 
            20                  25                  30          


Lys Phe Ser Ala Arg Thr Val Phe Gln Phe Pro Gln Gly Tyr Trp Leu 
        35                  40                  45              


Glu Asn Leu Ala Val Arg Gly Asn Gly Gln Val Leu Ala Thr Thr Tyr 
    50                  55                  60                  


Met Pro Ser Ala Gly Leu Tyr Leu Ile Asp Pro Thr Pro Asn Ala Ser 
65                  70                  75                  80  


Tyr Pro Ala Val Leu Val His Gln Phe Glu Asn Ser Thr Ser Ala Leu 
                85                  90                  95      


Gly Ile Val Glu Ala Glu Gly Thr Glu Pro Asp Thr Phe Tyr Leu Ala 
            100                 105                 110         


Thr Leu Asn Phe Ser Ala Ala Asp Gly Phe Val Pro Arg Thr Ser Gln 
        115                 120                 125             


Val Trp Arg Val Asp Met Ser Ser Phe His Tyr Ser Pro Gln Thr Gly 
    130                 135                 140                 


Gln Val Ser Gly Lys Ala Ala Val Ser His Val Thr Thr Leu Ser Ser 
145                 150                 155                 160 


Val Gly Met Ala Asn Gly Met Thr Leu Leu Ala Pro Asp Ser Ser His 
                165                 170                 175     


Ile Leu Ile Ala Asp Ser Leu Arg Gly Ala Ile Trp Asp Leu Asp Thr 
            180                 185                 190         


Ala Thr Gly His Tyr Gly Leu Ser Ser Ser Phe Pro Ala Met Arg Ser 
        195                 200                 205             


Asp Asn Pro Ala Arg Arg Phe Leu Gly Ile Asp Gly Val Lys Val His 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Phe Asn Asn Ala Gly Glu Phe Thr Leu Ala Arg 
225                 230                 235                 240 


Met Pro Ile His Ser Asp Gly Ile Ala Lys Gly Glu Pro Val Val Leu 
                245                 250                 255     


Ala Thr Asp Leu Tyr Ser Asp Gly Phe Cys Leu Tyr Asp Ala Asp Thr 
            260                 265                 270         


Val Leu Val Thr Met Asn Ile Asp Asn Gly Leu Ala Ala Leu Asp Leu 
        275                 280                 285             


Glu Ser His Arg Arg Trp Met Val Ala Gly Asn Met Pro Asp Gly Val 
    290                 295                 300                 


Phe Thr Thr Pro Thr Ser Val Glu Leu Gly Arg Gly Glu Asp Ala Gly 
305                 310                 315                 320 


Lys Leu Ala Tyr Val Thr Met Gly Gly Thr Tyr Val Ala Thr Gly Ala 
                325                 330                 335     


Glu Asp Leu Val Gly Gly Ser Leu Val Val Val Asp Leu Lys Ser Ala 
            340                 345                 350         


Thr Thr Asp Pro Lys Gly Thr Gly Arg Gly Gly Leu Leu Val Gln Glu 
        355                 360                 365             


Thr Glu Thr Ile Trp Leu Glu Leu 
    370                 375     


<210>  204
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 203

<400>  204

Met His Phe Asn Leu Leu Leu Val Leu Thr Val Leu Leu Arg Gln Ala 
1               5                   10                  15      


Thr Ala Leu Val Leu Pro Pro Ser Asn Ser Thr Ser Asn Ser Thr Pro 
            20                  25                  30          


Lys Phe Ser Ala Arg Thr Val Phe Gln Phe Pro Gln Gly Tyr Trp Leu 
        35                  40                  45              


Glu Asn Leu Ala Val Arg Gly Asn Gly Gln Val Leu Ala Thr Thr Tyr 
    50                  55                  60                  


Met Asn Ser Ala Gly Leu Tyr Leu Ile Asp Pro Thr Gln Asn Ala Pro 
65                  70                  75                  80  


Tyr Gly Ala Thr Leu Val His Gln Phe Glu Asn Ser Pro Ser Ala Leu 
                85                  90                  95      


Gly Ile Val Glu Ala Glu Gly Tyr Glu Pro Asp Thr Phe Tyr Leu Ala 
            100                 105                 110         


Thr Leu Asn Phe Ser Ala Ala Asp Gly Phe Pro Pro Arg Thr Phe Gln 
        115                 120                 125             


Val Trp Arg Val Asp Met Ser Ser Phe His Val Ser Pro Gln Thr Gly 
    130                 135                 140                 


Gln Val Ser Gly Lys Ala Ala Val Ser Leu Val Thr Thr Leu Ser Ser 
145                 150                 155                 160 


Val Gly Met Ala Asn Gly Met Thr Leu Leu Ala Pro Asp Ser Ser His 
                165                 170                 175     


Ile Leu Ile Ala Asp Ser Leu Arg Gly Ala Ile Trp Asp Leu Asp Thr 
            180                 185                 190         


Ala Thr Gly His Tyr Gly Leu Ser Ser Ser Phe Pro Ala Met Pro Ser 
        195                 200                 205             


Asp Asn Pro Ala Arg Arg Phe Leu Gly Ile Asp Gly Val Lys Val His 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Phe Asn Asn Ala Gly Glu Phe Thr Leu Ala Arg 
225                 230                 235                 240 


Met Pro Ile His Ser Asp Gly Val Ala Lys Gly Glu Phe Val Val Leu 
                245                 250                 255     


Ala Thr Asp Leu Tyr Ser Asp Gly Phe Cys Leu Tyr Asp Ala Asp Thr 
            260                 265                 270         


Val Leu Val Thr Met Asn Arg Asp Asn Gly Leu Ala Ala Leu Asp Leu 
        275                 280                 285             


Asp Ser His Arg Gly Trp Met Val Ala Gly Asn Met Pro Asp Gly Val 
    290                 295                 300                 


Phe Arg Thr Pro Thr Ser Val Glu Leu Gly Arg Gly Glu Asp Ala Gly 
305                 310                 315                 320 


Lys Leu Ala Tyr Val Thr Met Gly Gly Thr Tyr Val Ala Thr Gly Ala 
                325                 330                 335     


Glu Asp Leu Val Gly Gly Ser Leu Val Val Val Asp Leu Lys Ser Ala 
            340                 345                 350         


Thr Thr Asp Pro Lys Gly Thr Gly Arg Gly Gly Leu Leu Val Gln Glu 
        355                 360                 365             


Thr Glu Thr Ile Trp Leu Glu Leu 
    370                 375     


<210>  205
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 203

<400>  205

Met His Phe Asn Leu Leu Leu Val Leu Thr Val Leu Leu Arg Gln Ala 
1               5                   10                  15      


Thr Ala Leu Val Leu Pro Pro Ser Asn Ser Thr Ser Asn Ser Pro Pro 
            20                  25                  30          


Lys Phe Ser Ala Arg Thr Val Phe Gln Phe Pro Gln Gly Tyr Trp Leu 
        35                  40                  45              


Glu Asn Leu Ala Val Arg Gly Asn Gly Gln Val Leu Ala Thr Thr Tyr 
    50                  55                  60                  


Met Pro Thr Ala Gly Leu Tyr Leu Ile Asp Pro Arg Gln His Ala Ser 
65                  70                  75                  80  


Val Pro Ala Glu Leu Val His Gln Phe Glu Glu Ala Thr Ser Ala Leu 
                85                  90                  95      


Gly Ile Val Glu Ala Glu Gly Thr Glu Pro Asp Thr Phe Tyr Leu Ala 
            100                 105                 110         


Thr Leu Asn Phe Ser Ala Ala Asp Gly Phe Thr Pro Arg Thr Ser Ile 
        115                 120                 125             


Val Trp Arg Val Asp Met Ser Ser Phe Val Tyr Ser Pro Gln Thr Gly 
    130                 135                 140                 


Gln Val Ser Gly Pro Ala Ser Val Ser His Val Thr Thr Leu Ser Ser 
145                 150                 155                 160 


Val Gly Met Ala Asn Gly Met Thr Leu Leu Ala Pro Asp Cys Ser His 
                165                 170                 175     


Ile Leu Ile Ala Asp Ser Leu Arg Gly Ala Ile Trp Asp Leu Asp Thr 
            180                 185                 190         


Ala Thr Gly His Tyr Gly Leu Ser Ser Ser Phe Pro Ala Met Arg Ser 
        195                 200                 205             


Asp Asn Pro Ala Arg Arg Phe Leu Gly Ile Asp Gly Val Lys Val Arg 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Phe Asn Asn Ala Gly Glu Phe Thr Leu Ala Arg 
225                 230                 235                 240 


Met Pro Ile His Ser Asp Gly Ile Ala Lys Gly Glu Pro Val Val Leu 
                245                 250                 255     


Ala Thr Asp Leu Tyr Ser Asp Gly Phe Cys Leu Tyr Asp Ala Asp Thr 
            260                 265                 270         


Val Leu Val Thr Met Asn Ile Asp Asn Gly Leu Ala Ala Leu Asp Leu 
        275                 280                 285             


Glu Ser His Arg Arg Ala Met Val Ala Gly Asn Met Pro Asp Gly Val 
    290                 295                 300                 


Phe Thr Thr Pro Thr Ser Val Glu Leu Gly Arg Gly Glu Asp Ala Gly 
305                 310                 315                 320 


Lys Leu Ala Tyr Val Thr Met Gly Gly Thr Tyr Ala Ala Thr Gly Ala 
                325                 330                 335     


Glu Asp Leu Val Gly Gly Ser Leu Val Val Val Asp Leu Lys Ser Ala 
            340                 345                 350         


Thr Thr Asp Pro Lys Gly Thr Gly Arg Gly Gly Leu Leu Val Gln Glu 
        355                 360                 365             


Thr Glu Thr Ile Trp Leu Glu Leu 
    370                 375     


<210>  206
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 203

<400>  206

Met His Phe Asn Leu Leu Leu Val Leu Thr Val Leu Leu Arg Gln Ala 
1               5                   10                  15      


Thr Ala Leu Val Leu Pro Pro Ser Asn Ser Thr Ser Asn Ser Thr Gly 
            20                  25                  30          


Lys Phe Lys Ala Arg Thr Val Phe Gln Phe Pro Gln Gly Tyr Trp Leu 
        35                  40                  45              


Glu Asn Leu Ala Val Arg Gly Asn Gly Gln Val Leu Ala Thr Thr Tyr 
    50                  55                  60                  


Val Asn Ser Ala Gly Leu Tyr Leu Ile Asp Pro Lys Pro Pro Ala Ser 
65                  70                  75                  80  


Tyr Pro Ala Val Leu Val His Gln Phe Glu Asn Ser Thr Ser Ala Leu 
                85                  90                  95      


Gly Ile Val Glu Ala Glu Gly Thr Glu Pro Asp Thr Phe Tyr Leu Ile 
            100                 105                 110         


Thr Leu Asn Phe Ser Ala Ser Asp Gly Phe Val Pro Arg Thr Ser Ala 
        115                 120                 125             


Val Trp Arg Val Asp Met Ser Ser Phe His Tyr Ser Pro Gln Thr Gly 
    130                 135                 140                 


Gln Val Ala Gly Lys Ala Thr Val Ser His Val Thr Thr Leu Ser Gly 
145                 150                 155                 160 


Val Gly Met Ala Asn Gly Met Thr Leu Leu Ala Pro Asp Ser Ser His 
                165                 170                 175     


Ile Leu Ile Ala Asp Ser Leu Ala Gly Ala Ile Trp Asp Leu Asp Thr 
            180                 185                 190         


Val Thr Gly Glu Tyr Gly Leu Ser Ser Ser Phe Pro Ala Met Arg Ser 
        195                 200                 205             


Asp Asn Pro Pro Arg Arg Phe Leu Gly Ile Asp Gly Val Lys Val Ser 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Phe Asn Asn Ala Gly Glu Phe Thr Leu Ala Arg 
225                 230                 235                 240 


Met Pro Ile His Pro Asp Gly Lys Ala Lys Gly Glu Pro Val Val Leu 
                245                 250                 255     


Ala Tyr Asp Leu Tyr Trp Asp Gly Phe Cys Leu Tyr Asp Pro Asp Thr 
            260                 265                 270         


Val Leu Val Thr Met Asn Arg Asp Asn Glu Leu Ala Ala Leu Asp Leu 
        275                 280                 285             


Glu Ser His Arg Arg Trp Met Val Ala Gly Asn Met Asp Asp Gly Val 
    290                 295                 300                 


Phe Thr Thr Pro Thr Ser Val Glu Leu Gly Arg Gly Ser Asp Ala His 
305                 310                 315                 320 


Lys Leu Ala Tyr Val Thr Met Gly Gly Met Tyr Val Ala Thr Gly Ala 
                325                 330                 335     


Glu Asp Leu Val Gly Gly Ser Leu Val Val Val Asp Leu Lys Ser Ala 
            340                 345                 350         


Thr Thr Asp Pro Lys Gly Thr Gly Arg Gly Gly Leu Leu Val Gln Glu 
        355                 360                 365             


Thr Glu Thr Ile Trp Leu Glu Leu 
    370                 375     


<210>  207
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 203

<400>  207

Met His Phe Asn Leu Leu Leu Val Leu Thr Val Leu Leu Arg Gln Ala 
1               5                   10                  15      


Thr Ala Leu Val Leu Pro Pro Ser Leu Ser Thr Ser Ser Ser Leu Gly 
            20                  25                  30          


Lys Phe Ser Ala Arg Thr Val Phe Gln Phe Pro Asn Gly Tyr Trp Leu 
        35                  40                  45              


Glu Asn Leu Ala Val Arg Gly Asn Gly Ala Val Leu Ala Thr Thr Tyr 
    50                  55                  60                  


Met Pro Ile Ala Gly Leu Tyr Glu Ile Asp Pro Val Pro Pro Ala Ser 
65                  70                  75                  80  


Tyr Pro Ala Val Leu Val His Gln Phe Glu Gly Ser Thr Ser Ala Leu 
                85                  90                  95      


Gly Ile Val Glu Ala Glu Gly Thr Glu Pro Asp Thr Phe Tyr Leu Ala 
            100                 105                 110         


Thr Leu Asn Phe Ser Ala Ala Asp Gly Phe Leu Pro Arg Thr Ser Gln 
        115                 120                 125             


Val Trp Arg Val Asp Met Ser Ser Thr Glu Tyr Ser Pro Gln Thr Gly 
    130                 135                 140                 


Gln Val Ser Gly Lys Ala Ala Val Glu Gln Val Thr Thr Leu Ser Ser 
145                 150                 155                 160 


Val Leu Met Ala Asn Gly Met Thr Leu Leu Ala Lys Asp Glu Asp His 
                165                 170                 175     


Ile Leu Ile Ala Asp Ser Leu Arg Gly Leu Ile Trp Asp Leu Asp Thr 
            180                 185                 190         


Ala Thr Gly Lys Tyr Gly Leu Ser Ser Ser Ala Pro Ala Met Ala Ser 
        195                 200                 205             


Asp Asn Pro Ala Arg Arg Phe Leu Gly Ile Asp Gly Val Lys Val Gln 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Phe Asn Asn Ala Gly Glu Arg Thr Leu Gly Arg 
225                 230                 235                 240 


Met Pro Ile His Glu Asp Gly Glu Ala Lys Gly Glu Pro Val Val Leu 
                245                 250                 255     


Ala Thr Asp Val Tyr Ser Asp Gly Phe Cys Leu Tyr Asp Ala Asp Thr 
            260                 265                 270         


Ala Leu Val Thr Met Asn Ile Asp Asn Ser Leu Ala Ala Leu Ser Leu 
        275                 280                 285             


Glu Ser His Arg Arg Trp Met Val Ala Gly Asn Pro Val Asp Ser Val 
    290                 295                 300                 


Phe Thr Thr Pro Thr Ser Val Glu Leu Gly Arg Gly Glu Lys Ala Tyr 
305                 310                 315                 320 


Lys Leu Ala Tyr Val Thr Met Gly Gly Thr Tyr Val Ala Thr Gly Ala 
                325                 330                 335     


Glu Val Leu Val Gly Gly Ser Leu Val Val Val Asp Leu Lys Ser Ala 
            340                 345                 350         


Thr Thr Asp Pro Lys Gly Thr Gly Arg Gly Gly Leu Leu Val Gln Glu 
        355                 360                 365             


Thr Glu Thr Ile Trp Leu Glu Leu 
    370                 375     


<210>  208
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 203

<400>  208

Met His Phe Asn Leu Leu Leu Val Leu Thr Val Leu Leu Arg Gln Ala 
1               5                   10                  15      


Thr Ala Leu Val Leu Pro Pro Ser Asn Ser Thr Ser Asn Ser Leu Gly 
            20                  25                  30          


Lys Phe Ala Ala Arg Thr Val Phe Gln Phe Pro Gln Gly Tyr Trp Leu 
        35                  40                  45              


Glu Asn Leu Ala Val Arg Gly Asn Gly Gly Val Leu Ala Thr Thr Leu 
    50                  55                  60                  


Met Glu Thr Ala Gly Leu Tyr Leu Ile Asp Pro Thr Pro Asn Thr Ser 
65                  70                  75                  80  


Tyr Pro Ala Glu Leu Val His Gln Phe Glu Glu Ser Ser Ser Ala Leu 
                85                  90                  95      


Gly Ile Val Glu Ala Glu Gly Thr Glu Pro Asp Thr Phe Tyr Leu Ala 
            100                 105                 110         


Thr Leu Asn Phe Ser Ala Pro Asp Gly Phe Val Pro Arg Thr Ala Phe 
        115                 120                 125             


Val Trp Arg Val Asp Met Pro Ser Phe Arg Ile Ser Pro Gln Thr Gly 
    130                 135                 140                 


Gln Val Val Gly Thr Ala Asp Val Thr His Val Thr Thr Leu Ser Gly 
145                 150                 155                 160 


Val Gly Met Ala Asn Gly Met Thr Leu Leu Ala Pro Asp Ser Ser His 
                165                 170                 175     


Ile Leu Ile Ala Asp Ser Leu Leu Gly Ala Ile Trp Asp Leu Asp Thr 
            180                 185                 190         


Leu Thr Gly His Tyr Gly Leu Ser Ser Ser Phe Pro Leu Met Arg Ser 
        195                 200                 205             


Ser Asn Pro Ala Arg Arg Phe Leu Gly Ile Asp Gly Val Lys Val His 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Phe Asn Asn Ala Asp Glu Phe Thr Leu Cys Arg 
225                 230                 235                 240 


Met Pro Ile His Glu Lys Gly Ile Ala Lys Gly Glu Pro Val Val Leu 
                245                 250                 255     


Ala Ser Asp Lys Thr Ser Asp Gly Phe Cys Leu Tyr Asp Ala Asp Thr 
            260                 265                 270         


Val Leu Val Thr Met Asn Ile Asp Asn Gly Leu Ala Phe Leu Asp Leu 
        275                 280                 285             


Glu Ser His Arg Ile Trp Met Val Ala Gly Asn Met Pro Asp Gly Val 
    290                 295                 300                 


Phe Thr Thr Pro Thr Ser Val Glu Leu Gly Arg Gly His Asp Ala Gly 
305                 310                 315                 320 


Arg Leu Ala Tyr Val Thr Met Gly Gly Val Tyr Val Ala Thr Gly Ala 
                325                 330                 335     


Glu Leu Leu Val Gly Gly Ser Leu Val Val Val Asp Leu Lys Ser Ala 
            340                 345                 350         


Thr Thr Asp Pro Lys Gly Thr Gly Arg Gly Gly Leu Leu Val Gln Glu 
        355                 360                 365             


Thr Glu Thr Ile Trp Leu Glu Leu 
    370                 375     


<210>  209
<211>  1094
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  209
atggcctcca aggaaacttt cagcaaatac cctgccttcc ccgacaacat ccccacggcg       60

gcggtcccca agatctccct ccgccagatt ttgtcccgcg accccaccgt gtcgaagcgt      120

ctggtcgacg cgggcaagga attcggctgc ttcaaggtcg acctgaccga tgccatcgac      180

ggccctgtcc tctgtcaggg cgtcgagcgc ggctttgacc tgggcaaggc cttcttcgac      240

caagacatcg agaccaagaa ggcatacaag ctgagtcacg agaacgtcgg gtaggtttct      300

ccccagccga cgtcggccca gatgatactc acccacgggt gcacaggtac aagcaggccg      360

gcgttctggt cattaccaag gagcggcgag accaggtcga gacatgctcc gtctcgcgcg      420

atgatctggc ggccagccga cccgacctgc cctctgtgtt cgaccagcag cggctgctgc      480

tccagggcct cgttgcgcag ctcgggcagc tctcgcacct ggccgtctac catctgtcgg      540

agggtctggg gctggattat ggagtcgtgt cggcgcgcca tgatccccgc gaccagtccg      600

ccacgatgat ccgtttcctg cataatccgc cgcagagagg accgcgcgag gagctgccct      660

cgaccgagga cccgggttcg cgggcctacc tgatgggcca cagcgacggg ggcacggtga      720

ccatcctgtt caacgtcctg ggtggactgc agctccagcg ccagcagccc gatggctcca      780

tcgagtggca gtacattccg cccgagcccg gctgtgcctt gatcatggtg ggcgacgcct      840

tcaagtcctt cacggacggg gaagtcccct cgtgcgtgca ccgggtcatc cagccgccgg      900

gcgagcagga tcgcttcgat cggtatgcgc tgggcttctt cctcaagccc gccaacgggg      960

cctccattgg accagtgccg cgccggggcg tgacggagaa tggcgtcaac aaggcgtcgg     1020

actatggaga gtgggcaaag aacaagaacg cggcgttgta caacgagatg cgccaggaga     1080

atgtggcaat ttag                                                       1094


<210>  210
<211>  345
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  210

Met Ala Ser Lys Glu Thr Phe Ser Lys Tyr Pro Ala Phe Pro Asp Asn 
1               5                   10                  15      


Ile Pro Thr Ala Ala Val Pro Lys Ile Ser Leu Arg Gln Ile Leu Ser 
            20                  25                  30          


Arg Asp Pro Thr Val Ser Lys Arg Leu Val Asp Ala Gly Lys Glu Phe 
        35                  40                  45              


Gly Cys Phe Lys Val Asp Leu Thr Asp Ala Ile Asp Gly Pro Val Leu 
    50                  55                  60                  


Cys Gln Gly Val Glu Arg Gly Phe Asp Leu Gly Lys Ala Phe Phe Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Thr Lys Lys Ala Tyr Lys Leu Ser His Glu Asn Val 
                85                  90                  95      


Gly Tyr Lys Gln Ala Gly Val Leu Val Ile Thr Lys Glu Arg Arg Asp 
            100                 105                 110         


Gln Val Glu Thr Cys Ser Val Ser Arg Asp Asp Leu Ala Ala Ser Arg 
        115                 120                 125             


Pro Asp Leu Pro Ser Val Phe Asp Gln Gln Arg Leu Leu Leu Gln Gly 
    130                 135                 140                 


Leu Val Ala Gln Leu Gly Gln Leu Ser His Leu Ala Val Tyr His Leu 
145                 150                 155                 160 


Ser Glu Gly Leu Gly Leu Asp Tyr Gly Val Val Ser Ala Arg His Asp 
                165                 170                 175     


Pro Arg Asp Gln Ser Ala Thr Met Ile Arg Phe Leu His Asn Pro Pro 
            180                 185                 190         


Gln Arg Gly Pro Arg Glu Glu Leu Pro Ser Thr Glu Asp Pro Gly Ser 
        195                 200                 205             


Arg Ala Tyr Leu Met Gly His Ser Asp Gly Gly Thr Val Thr Ile Leu 
    210                 215                 220                 


Phe Asn Val Leu Gly Gly Leu Gln Leu Gln Arg Gln Gln Pro Asp Gly 
225                 230                 235                 240 


Ser Ile Glu Trp Gln Tyr Ile Pro Pro Glu Pro Gly Cys Ala Leu Ile 
                245                 250                 255     


Met Val Gly Asp Ala Phe Lys Ser Phe Thr Asp Gly Glu Val Pro Ser 
            260                 265                 270         


Cys Val His Arg Val Ile Gln Pro Pro Gly Glu Gln Asp Arg Phe Asp 
        275                 280                 285             


Arg Tyr Ala Leu Gly Phe Phe Leu Lys Pro Ala Asn Gly Ala Ser Ile 
    290                 295                 300                 


Gly Pro Val Pro Arg Arg Gly Val Thr Glu Asn Gly Val Asn Lys Ala 
305                 310                 315                 320 


Ser Asp Tyr Gly Glu Trp Ala Lys Asn Lys Asn Ala Ala Leu Tyr Asn 
                325                 330                 335     


Glu Met Arg Gln Glu Asn Val Ala Ile 
            340                 345 


<210>  211
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 210

<400>  211

Met Ala Ser Lys Glu Thr Phe Ser Lys Tyr Pro Ala Phe Pro Asp Asn 
1               5                   10                  15      


Ile Pro Thr Ala Ala Val Pro Lys Ile Ser Leu Arg Gln Ile Leu Ser 
            20                  25                  30          


Arg Asp Pro Thr Val Ser Lys Arg Leu Val Asp Ala Gly Lys Glu Phe 
        35                  40                  45              


Gly Cys Phe Lys Val Asp Leu Thr Asp Ala Ile Asp Gly Pro Val Leu 
    50                  55                  60                  


Cys Gln Gly Val Glu Arg Gly Phe Asp Trp Gly Lys Ala Phe Phe Asp 
65                  70                  75                  80  


Gln Asp Ala Glu Thr Lys Lys Ala Tyr Lys Leu Ser Asn Gln Asn Val 
                85                  90                  95      


Gly Tyr Lys Gln Ala Gly Glu Leu Val Ile Thr Ala Gly Arg Arg Asp 
            100                 105                 110         


Gln Val Glu Thr Cys Ser Val Ser Arg Asp Asp Leu Leu Arg Ser Arg 
        115                 120                 125             


Pro Asp Leu Pro Ser Val Phe Asp Gln Gln Arg Leu Leu Leu Gln Gly 
    130                 135                 140                 


Leu Val Ala Gln Leu Gly Gln Leu Ser Lys Leu Ala Val Tyr His Leu 
145                 150                 155                 160 


Ser Glu Gly Leu Gly Leu Asp Tyr Gly Phe Val Ser Ala Arg His Asp 
                165                 170                 175     


Pro Arg Asp Gln Ser Ala Thr Met Ile Arg Phe Leu His Asn Pro Pro 
            180                 185                 190         


Thr Arg Gly Pro Arg Pro Glu Leu Pro Ser Thr Glu Asp Pro Gly Ser 
        195                 200                 205             


Arg Ala Tyr Leu Met Gly His Ser Asp Gly Gly Thr Val Thr Ile Leu 
    210                 215                 220                 


Phe Asn Val Leu Gly Gly Leu Gln Leu Gln Arg Gln Gln Pro Asp Gly 
225                 230                 235                 240 


Ser Ile Glu Trp Gln Tyr Ile Pro Pro Glu Pro Gly Cys Ala Leu Ile 
                245                 250                 255     


Met Val Gly Asp Ala Phe Lys Ser Phe Thr Asp Gly Glu Val Pro Ser 
            260                 265                 270         


Cys Val His Arg Val Ile Gln Pro Pro Gly Gln Gln Asp Arg Ile Asp 
        275                 280                 285             


Arg Tyr Ala Leu Gly Phe Phe Leu Gly Pro Ala Asn Gly Ala Ser Ile 
    290                 295                 300                 


Gly Pro Val Pro Arg Arg Gly Val Thr Glu Asn Gly Val Asn Lys Ala 
305                 310                 315                 320 


Ser Asp Tyr Gly Gln Trp Ala Lys Asn Leu Asn Ala Ala Leu Tyr Asn 
                325                 330                 335     


Glu Met Arg Gln Glu Asn Val Ala Ile 
            340                 345 


<210>  212
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 210

<400>  212

Met Ala Ser Lys Glu Thr Phe Ser Lys Tyr Pro Ala Phe Pro Asp Asn 
1               5                   10                  15      


Ile Pro Glu Ala Ala Val Pro Lys Ile Ser Leu Arg Lys Ile Leu Ser 
            20                  25                  30          


Arg Asp Pro Thr Val Ser Lys Arg Leu Val Asp Ala Gly Lys Glu Phe 
        35                  40                  45              


Gly Cys Phe Lys Val Asp Leu Thr Asp Ala Ile Asp Gly Pro Val Leu 
    50                  55                  60                  


Cys Gln Gly Val Glu Arg Gly Phe Asp Leu Gly Lys Ala Phe Phe Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Thr Lys Lys Ala Tyr Lys Leu Ser Lys Ala Asn Val 
                85                  90                  95      


Gly Tyr Phe Gln Ala Gly Val Leu Val Ile Thr Lys Asp Arg Arg Asp 
            100                 105                 110         


Gln Val Glu Thr Cys Phe Val Ser Arg Asp Asp Leu Ala Ala Ser Arg 
        115                 120                 125             


Pro Leu Leu Pro Ser Val Phe Asp Gln Gln Arg Leu Leu Leu Gln Gly 
    130                 135                 140                 


Leu Val Ala Glu Leu Gly Gln Leu Ser His Leu Ala Val Tyr His Leu 
145                 150                 155                 160 


Ser Glu Gly Leu Gly Leu Asp Tyr Gly Val Val Ser Ala Arg His Asp 
                165                 170                 175     


Pro Arg Asp Gln Ser Ala Thr Met Ile Arg Phe Leu His Asn Pro Pro 
            180                 185                 190         


Gln Arg Gly Pro Arg Gln Glu Leu Gln Ser Thr Glu Asp Val Gly Ser 
        195                 200                 205             


Arg Leu Tyr Leu Met Gly His Ser Asp Gly Gly Thr Val Thr Ile Leu 
    210                 215                 220                 


Leu Asn Val Leu Gly Gly Leu Gln Leu Gln Arg Gln Asn Pro Asp Gly 
225                 230                 235                 240 


Ser Ile Glu Trp Gln Ala Ile Pro Pro Glu Pro Gly Cys Ala Leu Ile 
                245                 250                 255     


Met Val Gly Asp Ala Phe Lys Ser Phe Thr Asp Gly Glu Val Pro Ser 
            260                 265                 270         


Cys Val His Arg Val Ile Gln Pro Pro Gly Glu Gln Asp Arg Phe Asp 
        275                 280                 285             


Arg Tyr Ala Leu Gly Phe Phe Ser Glu Pro Ala Asn Gly Ala Ser Ile 
    290                 295                 300                 


Gly Pro Val Pro Arg Arg Gly Val Thr Glu Asn Gly Val Asn Lys Ala 
305                 310                 315                 320 


Ser Asp Tyr Gly Glu Trp Ala Lys Asn Lys Asn Ala Ala Leu Tyr Asn 
                325                 330                 335     


Glu Met Arg Gln Glu Asn Val Ala Ile 
            340                 345 


<210>  213
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 210

<400>  213

Met Ala Ser Lys Glu Thr Phe Ser Lys Tyr Pro Ala Phe Pro Asp Asn 
1               5                   10                  15      


Ile Pro Asp Ala Ala Val Pro Lys Ile Ser Leu Arg Gln Ile Leu Ser 
            20                  25                  30          


Arg Asp Pro Thr Val Ser Lys Arg Leu Val Asp Ala Gly Lys Glu Asp 
        35                  40                  45              


Gly Cys Phe Lys Val Asp Leu Thr Asp Ala Ile Asp Gly Pro Val Leu 
    50                  55                  60                  


Phe Gln Gly Val Glu Arg Gly Phe Asp Ser Gly Lys Ala Phe Phe Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Thr Lys Lys Ala Tyr Arg Leu Val His Asp Asn Val 
                85                  90                  95      


Gly Tyr Gly Gln Ala Gly Ser Leu Val Ile Thr Lys Glu Lys Arg Asp 
            100                 105                 110         


Gln Val Glu Thr Cys His Val Ser Arg Asp Asp Glu Ala Ala Thr Arg 
        115                 120                 125             


Pro Asp Leu Pro Ser Val Phe Asp Gln Gln Arg Leu Leu Leu Gln Gly 
    130                 135                 140                 


Leu Val Ala Gln Leu Glu Gln Leu Ser His Leu Ala Val Tyr His Leu 
145                 150                 155                 160 


Ser Glu Gly Leu Gly Leu Asp Tyr Gly Val Val Ser Lys Phe His Asp 
                165                 170                 175     


Pro Asp Asp Gln Ser Ala Thr Arg Ile Arg Phe Leu His Asn Pro Pro 
            180                 185                 190         


Gln Arg Gly Pro Arg Glu Glu Leu Pro Ser Leu Glu Asp Pro Gly Ser 
        195                 200                 205             


Arg Ala Tyr Leu Met Gly His Ser Asp Gly Gly Thr Val Thr Ile Leu 
    210                 215                 220                 


Phe Asn Val Leu Gly Gly Leu Gln Leu Gln Arg Gln Gln Lys Asp Gly 
225                 230                 235                 240 


Ser Ile Lys Trp Gln Tyr Ile Pro Pro Glu Pro Gly Cys Ala Leu Ile 
                245                 250                 255     


Met Val Gly Asp Ala Phe Lys Ser Phe Thr Asp Gly Glu Val Pro Ser 
            260                 265                 270         


Cys Leu His Arg Val Ile Gln Pro Pro Gly Glu Gln Gly Arg Phe Asp 
        275                 280                 285             


Arg Tyr Ala Leu Gly Phe Phe Leu Lys Pro Ser Asn Gly Ala Ser Ile 
    290                 295                 300                 


Gly Pro Val Pro Arg Arg Gly Leu Thr Glu Asn Gly Val Asn Lys Ala 
305                 310                 315                 320 


Ser Asp Tyr Gly Glu Trp Ala Lys Asn Lys Asn Ala Ala Leu Tyr Asn 
                325                 330                 335     


Glu Met Arg Gln Glu Asn Val Ala Ile 
            340                 345 


<210>  214
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 210

<400>  214

Met Ala Ser Lys Glu Thr Phe Ser Glu Tyr Pro Ala Phe Pro Asp Asn 
1               5                   10                  15      


Ile Pro Val Ala Ala Val Pro Lys Ile Ser Leu Arg Gln Ile Leu Thr 
            20                  25                  30          


Arg Asp Pro Thr Val Ser Lys Arg Leu Val Asp Ala Gly Lys Glu Phe 
        35                  40                  45              


Gly Cys Phe Lys Val Asp Leu Thr Asp Ala Ile Asp Gly Ser Val Leu 
    50                  55                  60                  


Cys Gln Gly Val Glu Arg Gly Phe Asp Gln Gly Lys Ala Phe Phe Asp 
65                  70                  75                  80  


Gln Asp Val Glu Thr Lys Lys Ala Tyr Arg Phe Ser Ala Asn Asn Val 
                85                  90                  95      


Gly Tyr Lys Gln Glu Gly Thr Leu Gln Ile Thr Lys Lys Arg Arg Asp 
            100                 105                 110         


Gln Val Glu Thr Cys Ser Val Ser Arg Asp Asp Pro Asn Ala Ser Arg 
        115                 120                 125             


Pro Asp Leu Pro Ser Val Phe Asp Gln Gln Arg Leu Lys Leu Ile Gly 
    130                 135                 140                 


Leu Val Ala Gln Leu Gly Gln Leu Ser Leu Ser Ala Val Tyr His Leu 
145                 150                 155                 160 


Ser Glu Gly Leu Gly Leu Asp Tyr Gly Val Val Ser Ala Leu His Asp 
                165                 170                 175     


Leu Arg Asp Arg Ser Ala Thr Leu Ile Arg Phe Leu His Asn Pro Pro 
            180                 185                 190         


Gln Arg Val Pro Arg Glu Glu Leu Pro Ser Thr Glu Asp Pro Thr Ser 
        195                 200                 205             


Arg Ala Tyr Leu Met Gly His Ser Asp Gly Gly Thr Val Thr Ile Leu 
    210                 215                 220                 


Leu Asn Val Leu Gly Gly Leu Gln Leu Gln Arg Gln Ser Val Asp Gly 
225                 230                 235                 240 


Ser Ile Glu Trp Gln Tyr Ile Pro Pro Glu Pro Gly Cys Ala Leu Ile 
                245                 250                 255     


Met Val Gly Asp Ala Phe Lys Ser Phe Thr Asp Gly Glu Val Pro Ser 
            260                 265                 270         


Cys Val His Arg Val Ile Cys Pro Pro Arg Glu Gln Gly Gly Phe Asp 
        275                 280                 285             


Arg Tyr Ala Leu Gly Phe Phe Leu Lys Pro Ala Asn Gly Ala Ser Ile 
    290                 295                 300                 


Gly Pro Val Pro Arg Arg Gly Val Thr Glu Asn Gly Val Asn Lys Ala 
305                 310                 315                 320 


Ser Asp Tyr Gly Asn Trp Ala Lys Gly Lys Asn Ala Ala Leu Tyr Asn 
                325                 330                 335     


Glu Met Arg Gln Glu Asn Val Ala Ile 
            340                 345 


<210>  215
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 210

<400>  215

Met Ala Ser Lys Glu Thr Phe Ser Lys Tyr Pro Ala Phe Pro Asp Asn 
1               5                   10                  15      


Val Pro Asp Ala Ala Val Pro Lys Ile Ser Leu Arg Gln Ile Lys Ser 
            20                  25                  30          


Arg Asp Pro Thr Val Ser Lys Arg Leu Thr Asp Ala Gly Lys Glu Val 
        35                  40                  45              


Gly Cys Phe Lys Val Asp Leu Thr Asp Ala Ile Asp Gly Pro Val Leu 
    50                  55                  60                  


Leu Gln Gly Val Glu Arg Gly Phe Asp Val Gly Lys Ala Phe Phe Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Thr Lys Lys Ala Tyr Lys Leu Ser Gly Phe Asn Val 
                85                  90                  95      


Gly Tyr Lys Gln Val Gly Val Leu Val Ile Thr Lys Glu Pro Arg Asp 
            100                 105                 110         


Gln Val Glu Thr Cys Tyr Val Ser Arg Asp Pro Leu Phe Ser Ser Arg 
        115                 120                 125             


Pro Asp Leu Pro Ser Tyr Phe Asp Gln Gln Arg Leu Leu Leu Gln Gly 
    130                 135                 140                 


Leu Val Ala Gln Leu Gly Gln Leu Ser Gln Leu Ala Val Tyr His Leu 
145                 150                 155                 160 


Ser Glu Gly Leu Gly Leu Asp Tyr Gly Val Val Ser Ala Arg His Asp 
                165                 170                 175     


Pro Arg Asp Pro Ser Ala Thr Met Ile Arg Phe Leu His Asn Pro Pro 
            180                 185                 190         


Gln Arg Gly Pro Arg Glu Glu Leu Pro Ser Thr Pro Gly Lys Pro Ser 
        195                 200                 205             


Arg Val Tyr Leu Met Gly His Ser Asp Val Gly Thr Val Thr Ile Leu 
    210                 215                 220                 


Phe Asn Val Leu Gly Gly Leu Gln Leu Gln Arg Gln Gln Lys Asp Gly 
225                 230                 235                 240 


Ser Ile Glu Trp Gln Ser Ile Pro Pro Glu Pro Gly Cys Ala Leu Ile 
                245                 250                 255     


Met Val Gly Asp Ala Phe Lys Ser Phe Thr Asp Gly Glu Val Pro Ser 
            260                 265                 270         


Cys Val His Arg Val Ile Gln Pro Pro Gly Glu Gln Gly Arg Lys Asp 
        275                 280                 285             


Arg Tyr Ala Leu Gly Phe Phe Leu Lys Pro Ala Ser Gly Ala His Ile 
    290                 295                 300                 


Ile Pro Val Pro Arg Arg Gly Val Lys Glu Asn Gly Val Asn Lys Ala 
305                 310                 315                 320 


Ser Asp Tyr Gly Gly Gln Ala Lys Asn Lys Asn Ala Ala Asp Tyr Asn 
                325                 330                 335     


Glu Met Arg Gln Glu Asn Val Ala Ile 
            340                 345 


<210>  216
<211>  911
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  216
atgtaccagg aagtcgactc catgatcgcc cagatagtag aagacgctgg aagcctccat       60

cgagctgttg cccaggtgga ggagttgacc ccgaagcttg ttgcagcgag tccttcctcc      120

gagaaagtac tcgtcccaat caagaaacaa atcgcagagt gcaaggcaga tctcagttcc      180

tggaataaga gaattgattc attggggcta tcgagagcga aagggatttc agcattcagg      240

aagaggttca aagcaactgt ggacaggtcg tttttcgaga atgtcagaag ccggctttgc      300

ttccatcggg agcaactgac tctgctactt acaaccgccg acgcgtatgt gactctatta      360

ccttgccgtt atttatccat ctaactgttg gtcaagtaat gttggagttg agagcctccc      420

gatgacaaac aaatccgaga tacgttccaa cttcgcgtcc gggaaccggg attccaagaa      480

cctgtctcgc gtcagctcac cacgattgac aaccggataa cagatcaatc agctagtttt      540

tttcctctac tcaacggcag ttcgataggt tcttcgatgg ctatttggag cagggaggac      600

aaactatatg ccgtcttgaa gctattgata cgaggttgca atgcctgcaa gcccggcttg      660

agcagtcgat caatccccaa agccagaaaa caacttacaa cccgaagaag tctagaagac      720

aagcatatgt acgacagatc ccacgcaaga cacggttgct ggagctcgtg ggctcgggaa      780

gaggtctcta tcatgctcac gaaagacaga ccgacattga agaatttcct ctgcgcgtga      840

tacagactgg gttgttgctc accgagcaaa aaggaaagat tatgtcgacc cttctcgctc      900

ttgaggattg a                                                           911


<210>  217
<211>  228
<212>  PRT
<213>  Paecilomyces divaricatus

<400>  217

Met Tyr Gln Glu Val Asp Ser Met Ile Ala Gln Ile Val Glu Asp Ala 
1               5                   10                  15      


Gly Ser Leu His Arg Ala Val Ala Gln Val Glu Glu Leu Thr Pro Lys 
            20                  25                  30          


Leu Val Ala Ala Ser Pro Ser Ser Glu Lys Val Leu Val Pro Ile Lys 
        35                  40                  45              


Lys Gln Ile Ala Glu Cys Lys Ala Asp Leu Ser Ser Trp Asn Lys Arg 
    50                  55                  60                  


Ile Asp Ser Leu Gly Leu Ser Arg Ala Lys Gly Ile Ser Ala Phe Arg 
65                  70                  75                  80  


Lys Arg Phe Lys Ala Thr Val Asp Arg Ser Phe Phe Glu Asn Val Arg 
                85                  90                  95      


Ser Arg Leu Cys Phe His Arg Glu Gln Leu Thr Leu Leu Leu Thr Thr 
            100                 105                 110         


Ala Asp Ala Phe Phe Asp Gly Tyr Leu Glu Gln Gly Gly Gln Thr Ile 
        115                 120                 125             


Cys Arg Leu Glu Ala Ile Asp Thr Arg Leu Gln Cys Leu Gln Ala Arg 
    130                 135                 140                 


Leu Glu Gln Ser Ile Asn Pro Gln Ser Gln Lys Thr Thr Tyr Asn Pro 
145                 150                 155                 160 


Lys Lys Ser Arg Arg Gln Ala Tyr Val Arg Gln Ile Pro Arg Lys Thr 
                165                 170                 175     


Arg Leu Leu Glu Leu Val Gly Ser Gly Arg Gly Leu Tyr His Ala His 
            180                 185                 190         


Glu Arg Gln Thr Asp Ile Glu Glu Phe Pro Leu Arg Val Ile Gln Thr 
        195                 200                 205             


Gly Leu Leu Leu Thr Glu Gln Lys Gly Lys Ile Met Ser Thr Leu Leu 
    210                 215                 220                 


Ala Leu Glu Asp 
225             


<210>  218
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 217

<400>  218

Met Tyr Gln Glu Val Asp Ser Met Ile Ala Gln Ile Val Glu Asp Ala 
1               5                   10                  15      


Gly Ser Leu His Arg Ala Val Thr Gln Val Glu Glu Leu Thr Pro Lys 
            20                  25                  30          


Leu Val Ala Ala Ser Pro Ser Ser Glu Lys Val Leu Val Pro Ile Leu 
        35                  40                  45              


Lys Gln Ile Ala Glu Cys Lys Gln Leu Leu Ser Glu Trp Asn Lys Arg 
    50                  55                  60                  


Ile Asp Ser Leu Gly Leu Ser Arg Ala Lys Gly Ile Ser Ala Phe Arg 
65                  70                  75                  80  


Lys Arg Phe Lys Ala Val Val Asp Arg Ser Phe Phe Glu Asn Val Arg 
                85                  90                  95      


Ser Arg Leu Cys Phe His Arg Glu Gln Leu Thr Leu Leu Leu Thr Thr 
            100                 105                 110         


Ala Asp Ala Phe Phe Asp Gly Tyr Leu Glu Gln Gly Gly Gln Thr Ile 
        115                 120                 125             


Cys Arg Leu Glu Ala Ile Asp Pro Arg Leu Gln Cys Leu Gln Ala Arg 
    130                 135                 140                 


Leu Glu Gln Ser Ile Asn Pro Gln Trp Gln Lys Thr Thr Tyr Asn Pro 
145                 150                 155                 160 


Lys Lys Ser Arg Arg Tyr Ala Tyr Glu Arg Gln Ile Pro Arg Ile Thr 
                165                 170                 175     


Arg Leu Leu Glu Leu Val Gly Ser Gly Arg Gly Leu Tyr His Ala His 
            180                 185                 190         


Glu Arg Gln Thr Asp Ile Glu Glu Phe Pro Leu Arg Val Ile Gln Thr 
        195                 200                 205             


Gly Leu Leu Leu Ser Glu Gln Lys Gly Lys Ile Met Ser Thr Leu Leu 
    210                 215                 220                 


Ala Leu Glu Asp 
225             


<210>  219
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 217

<400>  219

Met Tyr Gln Glu Val Asp Ser Met Ile Ala Gln Ile Val Glu Asp Ala 
1               5                   10                  15      


Gly Lys Leu His Arg Ala Val Ala Gln Val Glu Glu Leu Thr Pro Lys 
            20                  25                  30          


Leu Val Asn Ala Ser Ala Ser Ser Glu Lys Val Leu Asn Pro Ile Lys 
        35                  40                  45              


Asp Gln Ile Ala Glu Cys Lys Ala Asp Leu Ser Ser Trp Asn Lys Arg 
    50                  55                  60                  


Ile Asp Ser Leu Thr Leu Ser Arg Ala Lys Gly Ile Ser Ala Phe Arg 
65                  70                  75                  80  


Lys Arg Phe Lys Ala Thr Val Asp Arg Ser Phe Phe Glu Asn Val Arg 
                85                  90                  95      


Ser Arg Leu Cys Phe His Arg Glu Gln Leu Thr Leu Leu Leu Thr Thr 
            100                 105                 110         


Ala Asp Ala Phe Phe Asp Gly Tyr Leu Glu Gln Gly Gly Gln Thr Ile 
        115                 120                 125             


Cys Arg Leu Glu Ala Ile Asp Pro Arg Leu Gln Cys Leu Gln Ala Arg 
    130                 135                 140                 


Leu Glu Gln Ser Tyr Gly Pro Gln Ser Leu Lys Thr Thr Tyr Asn Pro 
145                 150                 155                 160 


Lys Lys Ser Arg Arg Glu Ala Tyr Val Arg Gln Ile Pro Arg Lys Thr 
                165                 170                 175     


Arg Leu Leu Glu Leu Val Gly Ser Gly Arg Gly Leu Tyr His Ala His 
            180                 185                 190         


Glu Arg Gln Thr Asp Ile Glu Glu Phe Pro Leu Arg Val Arg Gln Thr 
        195                 200                 205             


Gly Leu Leu Leu Thr Glu Gln Lys Gly Lys Ile Met Ser Thr Leu Leu 
    210                 215                 220                 


Ala Leu Glu Asp 
225             


<210>  220
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 217

<400>  220

Met Tyr Gln Glu Val Asp Ser Arg Ile Ala Gln Ile Val Glu Gly Ala 
1               5                   10                  15      


Arg Leu Leu His Arg Ala Val Ala Gln Val Glu Glu Lys Leu Pro Lys 
            20                  25                  30          


Leu Val Ala Ala Ser Pro Ser Ser Glu Lys Val Leu Val Pro Ile Lys 
        35                  40                  45              


Lys Gln Ile Ala Glu Leu Lys Ala Asp Leu Ser Ser Trp Asn Lys Arg 
    50                  55                  60                  


Ile Asp Ser Leu Gly Leu Ser Arg Ala Lys Gly Ile Ser Trp Phe Arg 
65                  70                  75                  80  


Lys Arg Phe Lys Ala Thr Val Asp Arg Ser Phe Phe Glu Asn Val Arg 
                85                  90                  95      


Ser Arg Leu Cys Phe His Arg Glu Gln Leu Thr Leu Leu Leu Thr Thr 
            100                 105                 110         


Ala Asp Ala Phe Phe Asp Thr Tyr Leu Glu Gln Gly Gly Gln Thr Ile 
        115                 120                 125             


Cys Arg Leu Glu Ala Ile Asp Pro Arg Leu Gln Cys Leu Gln Ala Arg 
    130                 135                 140                 


Leu Glu Gln Ser Ile Ala Pro Gln Ser Ala Lys Thr Thr Tyr Asn Pro 
145                 150                 155                 160 


Lys Lys Ser Arg Arg Leu Ala Tyr Val Arg Gln Ile Pro Glu Ser Thr 
                165                 170                 175     


Arg Leu Leu Glu Leu Val Gly Ser Gly Arg Gly Leu Tyr His Ala His 
            180                 185                 190         


Glu Arg Gln Thr Asp Ile Glu Glu Phe Pro Leu Arg Val Phe Gln Thr 
        195                 200                 205             


Gly Leu Leu Leu Thr Glu Gln Lys Gly Lys Ile Met Ser Thr Leu Leu 
    210                 215                 220                 


Ala Leu Glu Asp 
225             


<210>  221
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 217

<400>  221

Met Tyr Gln Glu Val Asp Ser Glu Ile Ala Gln Ile Val Gln Asp Ala 
1               5                   10                  15      


Gly Ser Leu Asn Glu Ala Val Ala Gln Val Glu Glu Leu Thr Pro Lys 
            20                  25                  30          


Leu Val Ala Leu Ser Pro Ser Ser Glu Lys Val Leu Asn Pro Ile Lys 
        35                  40                  45              


Lys Gln Ile Ala Leu Cys Lys Ala Asp Leu Ser Ile Trp Asn Lys Arg 
    50                  55                  60                  


Ile Asp Ser Leu Gly Val Ser Arg Ala Lys Gly Ile Ser Ala Phe Arg 
65                  70                  75                  80  


Lys Gln Phe Lys Ala Thr Val Asp Arg Ser Phe Phe Glu Asn Val Arg 
                85                  90                  95      


Ser Arg Leu Ala Phe His Arg Glu Gln Leu Thr Leu Leu Leu Thr Thr 
            100                 105                 110         


Ala Asp Ala Phe Phe Asp Leu Tyr Leu Glu Gln Gly Gly Phe Ser Leu 
        115                 120                 125             


Cys Arg Leu Glu Ala Ile Asp Thr Arg Leu Gln Cys Leu Gln Ala Arg 
    130                 135                 140                 


Leu Glu Gln Ser Ile Asn Gly Gln Met Gly Lys Thr Thr Tyr Asn Pro 
145                 150                 155                 160 


Lys Lys Ser Arg Arg Gln Ala Leu Val Arg Gln Ile Pro Pro Glu Thr 
                165                 170                 175     


Arg Leu Leu Glu Leu Val Gly Ser Gly Arg Gly Leu Tyr His Ala His 
            180                 185                 190         


Glu Arg Gln Thr Asp Ile Glu Glu Phe Pro Leu Asn Val Ile Gln Thr 
        195                 200                 205             


Gly Leu Leu Leu Phe Glu Gln Lys Gly Lys Ile Met Ser Thr Leu Leu 
    210                 215                 220                 


Ala Leu Glu Asp 
225             


<210>  222
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 217

<400>  222

Met Tyr Gln Glu Val Asp Ala Thr Ile Ala Gln Ile His Glu Asp Ala 
1               5                   10                  15      


Gly Ser Leu His Arg Ala Val Gln Gln Val Glu Glu Leu Thr Pro Lys 
            20                  25                  30          


Leu Arg Asp Gln Ser Thr Ser Ser Glu Lys Val Leu Ser Tyr Ile Lys 
        35                  40                  45              


Lys Gln Ile Ala Glu Cys Lys Ala Asp Leu Ser Ser Trp Asn Lys Arg 
    50                  55                  60                  


Ile Asp Ser Leu Gly Thr Ser Arg Ala Lys Gly Ile Ser Val Phe Arg 
65                  70                  75                  80  


Lys Thr Phe Lys Ala Thr Val Asp Arg Ser Phe Phe Glu Asn Val Arg 
                85                  90                  95      


Ser Arg Leu Cys Phe His Arg Glu Gln Leu Thr Leu Leu Leu Thr Thr 
            100                 105                 110         


Ala Asp Ala Phe Phe Asp Gly Tyr Leu Glu Gln Gly Gly Gln Ala Ile 
        115                 120                 125             


Glu Arg Leu Glu Ala Ile Asp Thr Arg Leu Gln Cys Leu Gln Ala Arg 
    130                 135                 140                 


Leu Glu Gln Ile Phe Asn Pro Gln Ser Val Lys Thr Thr Tyr Asn Pro 
145                 150                 155                 160 


Lys Lys Ser Arg Arg Thr Ala Tyr Val Arg Ala Ile Pro Arg Lys Arg 
                165                 170                 175     


Arg Leu Leu Glu Leu Val Gly Ser Gly Arg Gly Leu Tyr His Ala His 
            180                 185                 190         


Glu Arg Gln Thr Asp Ile Glu Glu Phe Pro Leu Arg Gly Val Gln Thr 
        195                 200                 205             


Gly Leu Leu Leu Thr Glu Gln Lys Gly Lys Ile Met Ser Thr Leu Leu 
    210                 215                 220                 


Ala Leu Glu Asp 
225             


<210>  223
<211>  955
<212>  DNA
<213>  Paecilomyces divaricatus

<400>  223
ggacaattgt ctctatcgta gatgtatctt gtaaagtcgt ctgcgatgcc ttcgaggggc       60

ggagactcta aaagagaatc aagagataag aagattgaaa agtatcagat cgagaactac      120

agaaagtgat gtgaacaatg agagcacaat caaacacgga aggctgaata gcatggctgt      180

cgatgtgact cgacagataa aatggtggtc atgaaggcat agaccgtagg acgagtggtt      240

gatacagaag aggagagcca gcggtgagtc ggcggtggcg tggacgtcgg tgactcgacg      300

ggataagccc tgctcaccgc tttcctcttt tgacgtcgcc gagaacgctc gaccgatctg      360

gcaaggtctg atctcggccg gagtaataaa ttatccgcaa tcccaagtca tgtgatgcgc      420

caaggccctt gcctgcttca ggttaggctg tggcttgcat ctcagcaggg aagcgccaca      480

gatctaagga tcatcgcgac gtcatggatg gtgacatcga cgaggaagac gcgttcagtc      540

ttgtttctca agccacaatg atccctgctg gggtctggaa cgtcagccaa ggctccgatg      600

tgatcaagcg cggggacacg aatctccact cttgattcaa tggcactatt ttccagccct      660

gatatccagt cgttcaagtg tggggacgct caaggtagga taatgtagga taacgtacct      720

aggataccag tttccttgta tgtatgtcct gcaagtaatt actcgtgtat ttaccatgtg      780

ctcctgaatc gacgtcatgg actgagggag agatgtgaaa tccgtggtat ataaacctcc      840

acgatcttcc agctttctgc atacaacagc aatctccatc tcaaacactt aaccactctc      900

tcgaagataa ctactctttt caaaccaaaa cttcttcatt caaacaactg caaac           955


<210>  224
<211>  9956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Transporter 1 Ts

<400>  224
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgacagc ttcagagcag acagcattgc tgggttcgcc taggaagccc gcctacacaa     7620

tcttttccaa tagtcagaag ctccttatta ttcttactgc gactttagca tctgtttttt     7680

ctcctctttc cgcaaatatc tactatccgg cgttgaaaag tattcaaaag gagctgaatg     7740

tgagcgagga gatacttaat atgacaatta cctcttatat ggtaggtttc acctcacgaa     7800

tgcaaaatgg agcataagaa gaattggacg taacaattag tccagatatt ccagggtctt     7860

tcaccaacct ttatcggatc tctatcagac acaatcggaa gacgcccagt ctacatcatt     7920

tgcttcctta tatatattgc cgccaatgtc ggattaacat ttcaaaccac gtttattgga     7980

ctcctcctac ttcgatgcct ccaaagttct ggtagtagct cgacagtaaa cctcgcctat     8040

ggtgtaactg cggatgtcgt gacgtccgct gagcgaggcc gatatgtagg actggcatct     8100

gttggcccaa tcattggacc tactttgggc ccagtactcg gaggtatcat tagccagtac     8160

tacggatggc gattcatctt cgttgttttg acgggaatgg cacttatcat gctcattttt     8220

attattgtct tcttacctga aacatgtcga aatattgtcg gaaatggatc tctcgaacca     8280

ctttctgtat ggaataagcc tctgagttcc tttctttgta agaagaaaga aaatgaggac     8340

cttgatgaaa ctctcgaggc acaacaggct atcgaagccg cccgtaaaaa gggtggtaag     8400

ccaaagccat ggaaatcact aactctactc ttcacatacc caactggatg cgtcattctt     8460

ttcaatggat tcacatttgc tacatactac gccgttacga ccagtctcac ctggtgcttt     8520

tctagtacct accacttcaa cgaggtcgaa atcggacttt cctacatacc catcggcgtt     8580

ggtagcatga ttgcagcttt caccaacgga ttccttctcg actggaacta tcgacgtgcg     8640

gtcaagaaag ttctcggtcg gcctcttgct cgcggcgagc atttcgatca tgatacaggt     8700

gtcgctctcg gcttccacat cgagcggacc cgcttacaga tcgtcatacc ggctgtcgtg     8760

cttgccatgc tggccatggt tgcttacggc tggtccgtgt atcttgtgct tacacctgct     8820

gttcctcttg tgttgctgtt tctctttgga tggctcggta cagctgctta ttccggcatg     8880

aacgtgttga ttgttgattt gaatctcaag tctccggcca ccgctaccgc agcgaataac     8940

ttgatacgtt gcatgttagg tgcattgggg gcaatggtta ttatgcctat catcaacgct     9000

gtcggaatgg ggtggacatt tatcatgatt tcaggggttt ggattgtatt gagtcctctg     9060

attatactcg ttgcgtggag caaaagtagt gagtagggat ccacttaacg ttactgaaat     9120

catcaaacag cttgacgaat ctggatataa gatcgttggt gtcgatgtca gctccggagt     9180

tgagacaaat ggtgttcagg atctcgataa gatacgttca tttgtccaag cagcaaagag     9240

tgccttctag tgatttaata gctccatgtc aacaagaata aaacgcgttt cgggtttacc     9300

tcttccagat acagctcatc tgcaatgcat taatgcattg gacctcgcaa ccctagtacg     9360

cccttcaggc tccggcgaag cagaagaata gcttagcaga gtctattttc attttcggga     9420

gacgagatca agcagatcaa cggtcgtcaa gagacctacg agactgagga atccgctctt     9480

ggctccacgc gactatatat ttgtctctaa ttgtactttg acatgctcct cttctttact     9540

ctgatagctt gactatgaaa attccgtcac cagcccctgg gttcgcaaag ataattgcac     9600

tgtttcttcc ttgaactctc aagcctacag gacacacatt catcgtaggt ataaacctcg     9660

aaaatcattc ctactaagat gggtatacaa tagtaaccat gcatggttgc ctagtgaatg     9720

ctccgtaaca cccaatacgc cggccgaaac ttttttacaa ctctcctatg agtcgtttac     9780

ccagaatgca caggtacact tgtttagagg taatccttct ttctagaagt cctcgtgtac     9840

tgtgtaagcg cccactccac atctccactc gacctgcagg catcgagcct aggctagctc     9900

tagaccacac gtgtgggggc ccgttaacgt taactggttc ccggtcggca tctact         9956


<210>  225
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Phsp9 fw (MoA 657)

<400>  225
ccaaggctcc gatgtgatca ag                                                22


<210>  226
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Transporter 1 Ts rv (MoA 1093)

<400>  226
agagcgacac ctgtatcatg atcg                                              24


<210>  227
<211>  10143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Transporter 2 Ts

<400>  227
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgccgga accgttcaac tccaccatgc ctctcccttc tcctcctaac gcacaaccca     7620

aagatgaaaa ggttgggctt caagactcca accaaccacc ggaaatgtca gcgtcctcag     7680

agaagaaaca tcctgaaaat gaaaaccggc aatcgcagca gaatttgcgt ccaaccgagt     7740

cagaaaacaa tgagccgtac tctgttcata gctccagcgc caaaaaacta atggtcttag     7800

ctgcgtcact tgctgggttt ttctcgcctt tgtcggccag tatatactat cctgcattgc     7860

cggcgattga gaaggccttg aatgtatcca gtacacaggt caatttgaca gtcaccacgt     7920

atttggtatg ttcgttgctc ggaaagtgtc ccagcccatt caatttcctg acctgataca     7980

gattctacaa ggcttagcac cgatggtaac tgccagtttc agcgacagtg ctggacgtcg     8040

gcctggttac gcaatatgtt ttatagtcta cctcgctgcg aatctgggcc tcgcgttgca     8100

aaatagctat gccgcattaa tggtattacg agcactacaa tcagctggga gtagcggagc     8160

catagccatc gcgaacggtg tcgtcagtga cattatcaca ccgcaagaac gtggtagtta     8220

tattgcgttt gcctccgttg gatccatcct gggaccttcc ctatcaccca tcattggagg     8280

tctgtttgcc gagtatacgg attggcattg gattttctgg ttcctgttga tctttagcgg     8340

tgcattctgt gttcccttct ttctcttctt cccggaaact tgtcgtaaga ttgtgggtaa     8400

tgggaaaggg gtaccgccat tctggaatcg caatctacca gatatattgc gcgcacgaaa     8460

ggagaagcaa aggcaacaac gcgccgagaa tgaagaagaa aatgctaatc ggcaacgttc     8520

ccgtctatcc attccaaacc ccttgaaagt cttcgtcgtt ttcaccaacc ttcaaaccgt     8580

catgacgctc tgccctgccg gtgtggcatt cggaagctac tatgctgttt tgacaggcgc     8640

ctcgggtgaa ttcacaaggg tttaccactt cagcgagatc aaagtagctc tcatatttct     8700

acccatgggt gtcggcggat tgatttcagc tttatctaca ggtaaactgg tgaattggaa     8760

tttccaccgt cacgcgcgca aacgtggtat catggttgct cgaaaccgga gacaggaact     8820

actcaatttc cccatcgagc gagccaggct agagattgcc cttccagtgt tttgtcttgg     8880

gtgcgtctgc actgtgctct atggctggtt gatgactcaa gatgtgaacg tatctggccc     8940

aatcattcta ctcttcgtta tgagttggtc ctttgccgca ttttaccaag ttctcaacgt     9000

cttattagtc gacacctatc ccggccgagg agcgatggtg actgcagtcg taaacctgct     9060

tagatgtgag attggtgctg gtatggcggc aatgatcagt ccgttgacca gcgctactgg     9120

ttctgggtgg tcgtatacga ttattgcctt gattggggtt gctgccacta gtccgttgct     9180

gctaacgatg aagtatggga tgaaatggag acaagagagt gcagcaaaag cagaagagaa     9240

gaagagtaga atgcaggagg cgcagcaaag acaggaggtt tagggatcca cttaacgtta     9300

ctgaaatcat caaacagctt gacgaatctg gatataagat cgttggtgtc gatgtcagct     9360

ccggagttga gacaaatggt gttcaggatc tcgataagat acgttcattt gtccaagcag     9420

caaagagtgc cttctagtga tttaatagct ccatgtcaac aagaataaaa cgcgtttcgg     9480

gtttacctct tccagataca gctcatctgc aatgcattaa tgcattggac ctcgcaaccc     9540

tagtacgccc ttcaggctcc ggcgaagcag aagaatagct tagcagagtc tattttcatt     9600

ttcgggagac gagatcaagc agatcaacgg tcgtcaagag acctacgaga ctgaggaatc     9660

cgctcttggc tccacgcgac tatatatttg tctctaattg tactttgaca tgctcctctt     9720

ctttactctg atagcttgac tatgaaaatt ccgtcaccag cccctgggtt cgcaaagata     9780

attgcactgt ttcttccttg aactctcaag cctacaggac acacattcat cgtaggtata     9840

aacctcgaaa atcattccta ctaagatggg tatacaatag taaccatgca tggttgccta     9900

gtgaatgctc cgtaacaccc aatacgccgg ccgaaacttt tttacaactc tcctatgagt     9960

cgtttaccca gaatgcacag gtacacttgt ttagaggtaa tccttctttc tagaagtcct    10020

cgtgtactgt gtaagcgccc actccacatc tccactcgac ctgcaggcat cgagcctagg    10080

ctagctctag accacacgtg tgggggcccg ttaacgttaa ctggttcccg gtcggcatct    10140

act                                                                  10143


<210>  228
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Transporter 2 Ts rv (MoA 1094)

<400>  228
cccatgggta gaaatatgag agctac                                            26


<210>  229
<211>  9075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Hypothetical protein Ts

<400>  229
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgattct attttctatt tttgtagctc ttcttgccgc tactagagcg caatctcaga     7620

cacctcctgg gtttaagccc tctactgagc tacacctcgg cgtgacattt caagatggag     7680

tttcagtcca agctggccat gaattattgg caaatggtaa atctactcag tccagcgctt     7740

tcactctaag cgattctaac aaaattcaca agaagccaaa tccgctcctc aactcgattt     7800

gcactcgctc ctagctattc accataccca aacacccttc taccattcga cttggaaatt     7860

catggttttc atgatcgaca tagacgttga acgtaacggc accaagtatc ctcttctaca     7920

ttggtaccaa ccggacctca tcctcagcgg tcgaaccggc agactatcga ttgaaagtga     7980

tagcaacatg ccaaaggcaa tgtatgctgg tccagcgcct ccaccgggac ccgctcatcg     8040

ttatgttgaa gtgatattca aacaaccaga aagatatgag ctgccagcag atttcgagaa     8100

gtttttagag aacacgattg cggcgaggtt ggggtttgat atcgagcaat ttgtgaaaga     8160

agccgggctg agtgaaccag ttgctgggaa ctggtttttg acagcaacga gctgaggatc     8220

cacttaacgt tactgaaatc atcaaacagc ttgacgaatc tggatataag atcgttggtg     8280

tcgatgtcag ctccggagtt gagacaaatg gtgttcagga tctcgataag atacgttcat     8340

ttgtccaagc agcaaagagt gccttctagt gatttaatag ctccatgtca acaagaataa     8400

aacgcgtttc gggtttacct cttccagata cagctcatct gcaatgcatt aatgcattgg     8460

acctcgcaac cctagtacgc ccttcaggct ccggcgaagc agaagaatag cttagcagag     8520

tctattttca ttttcgggag acgagatcaa gcagatcaac ggtcgtcaag agacctacga     8580

gactgaggaa tccgctcttg gctccacgcg actatatatt tgtctctaat tgtactttga     8640

catgctcctc ttctttactc tgatagcttg actatgaaaa ttccgtcacc agcccctggg     8700

ttcgcaaaga taattgcact gtttcttcct tgaactctca agcctacagg acacacattc     8760

atcgtaggta taaacctcga aaatcattcc tactaagatg ggtatacaat agtaaccatg     8820

catggttgcc tagtgaatgc tccgtaacac ccaatacgcc ggccgaaact tttttacaac     8880

tctcctatga gtcgtttacc cagaatgcac aggtacactt gtttagaggt aatccttctt     8940

tctagaagtc ctcgtgtact gtgtaagcgc ccactccaca tctccactcg acctgcaggc     9000

atcgagccta ggctagctct agaccacacg tgtgggggcc cgttaacgtt aactggttcc     9060

cggtcggcat ctact                                                      9075


<210>  230
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Hypothetcial protein Ts rv (MoA 1091)

<400>  230
ccagttccca gcaactggtt c                                                 21


<210>  231
<211>  9898
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Methylcitrate synthase Ts

<400>  231
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgactga cgagataccc tttgataaac cgatccgcga tatcgcatct tatgtacaca     7620

attacacaat tccttcatct ccaacatcct ttaagcacgc gcgtggcgtg attctcgatt     7680

cacttggttg cgcaatagaa acattgcata gatcttcaga agcatgtaca ttacttggtc     7740

ccgtcattcc cggaacaact tttccgtatg gctttcatct tccaggaaca tcatacgttc     7800

tggatccagt gaagggaaca tttgatcttg gagttttgat tagatacctg gatcataatg     7860

acgcttttgg cggagcggaa tggggccatc catcagatac actgtctgcc attattgcgg     7920

taatggattg gttatgtcga gctgagcaga gaagctcaac cacttccata agatacccgc     7980

cgttgacaat caaaacatta ctagaagcag cgataaaagc ctacgaaatc caaggatgtt     8040

atcaactcca gaatgccttc aatgcatatg gtattgacca cgtgatcctg gtcaaacttg     8100

cagctgcgtc tgtatgttca tggctgatgg gcatgactga aacacaaacg atgtcagtca     8160

tttctcacgt gtggatggat ggtcacccgt ctcgcgtcta cagatcggga gccaacacta     8220

cttcgcgcaa gggctgggca gctgctgatg ccgcgatgag agctgttcat ctctgcttgc     8280

ttacgcatgc tggtcaattg ggatctaaac agccattgaa tgataagcgt tacgggttct     8340

tggtgcatac atttggtctc gaggctggat tcgcgttacc cagggctttt ggtgactggg     8400

caattcagaa tatctttacc aagctaatgc cttgcgaagg acacgggata tcggctgtcg     8460

aagcggcact agtacaaggc cggaaactca aatcttgcgg tcatacagtg agcgatataa     8520

agcacattga tctacgtgtc acggctgccg cgaacctaat aattagcaaa ataggtcgat     8580

tatacaacgc agctgatcgg gaccattgca ttcaatatgt gattgcgctg gcattcttga     8640

aaggccgctt tccagatgca gaagattata tggatgacag cccgtatgca aatagcaagg     8700

agatggatga cttacgggaa aaaattatga tgaaggtgga tcaagaccta acacagggat     8760

atcttgatcc ggagaggaaa agttgcggaa ctggaatgac ggtttatttg aacaatggaa     8820

ctgtactaga cgaggttctg gttgaatatc cggctggaca tttgaagaat ccgaggacga     8880

aggaactaca ccagaggaaa ttcgagaaaa acatgaggtt ggcatttacc gatgccgaaa     8940

ttgcaaatat tgtgaagtgt attgaggatg atgagatgcc tatttcgtca tttgtggatt     9000

tgtttacgag ggattcaaag ggaatggcaa aactatgagg atccacttaa cgttactgaa     9060

atcatcaaac agcttgacga atctggatat aagatcgttg gtgtcgatgt cagctccgga     9120

gttgagacaa atggtgttca ggatctcgat aagatacgtt catttgtcca agcagcaaag     9180

agtgccttct agtgatttaa tagctccatg tcaacaagaa taaaacgcgt ttcgggttta     9240

cctcttccag atacagctca tctgcaatgc attaatgcat tggacctcgc aaccctagta     9300

cgcccttcag gctccggcga agcagaagaa tagcttagca gagtctattt tcattttcgg     9360

gagacgagat caagcagatc aacggtcgtc aagagaccta cgagactgag gaatccgctc     9420

ttggctccac gcgactatat atttgtctct aattgtactt tgacatgctc ctcttcttta     9480

ctctgatagc ttgactatga aaattccgtc accagcccct gggttcgcaa agataattgc     9540

actgtttctt ccttgaactc tcaagcctac aggacacaca ttcatcgtag gtataaacct     9600

cgaaaatcat tcctactaag atgggtatac aatagtaacc atgcatggtt gcctagtgaa     9660

tgctccgtaa cacccaatac gccggccgaa acttttttac aactctccta tgagtcgttt     9720

acccagaatg cacaggtaca cttgtttaga ggtaatcctt ctttctagaa gtcctcgtgt     9780

actgtgtaag cgcccactcc acatctccac tcgacctgca ggcatcgagc ctaggctagc     9840

tctagaccac acgtgtgggg gcccgttaac gttaactggt tcccggtcgg catctact       9898


<210>  232
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Methylcitrate synthase Ts rv (MoA 1088)

<400>  232
ccatctcctt gctatttgca tacg                                              24


<210>  233
<211>  9236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Thioesterase Ts

<400>  233
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgtccag agctcacccc aagcagcccg tcactggaag aaatattccc atattggcta     7620

tcacgatgcc cgcactcaag ttgctttgct tacatggcgc tggcatgaat tctgaggtat     7680

tgataaaact aagtgactta gtcttatcca aattctaata cggaactata gattatgaaa     7740

tctcatctgt catccttggc caaaaccctg gaataccgca acatcgccca attcgcatac     7800

gcagagggat ccgtcgagac agagcccggc cctggaatta ccccaggctt atacgagggc     7860

ccatattact cctttcacat ctggcctcca aaagcgggaa acctacaaga cgaagaatcc     7920

atccaaaatg catatgaaga gctcctcgag ataatcgacg acgagggtcc atttgacgga     7980

ctattgggtt tttctcacgg cggttcattc cttgctgaat tattagccag atacgctcgt     8040

gataatcctg caacagatgt tgaacggcta gctcgctgtg cggtctttat taattcgttc     8100

ccaccttttc gtaacgatcc ggaccagaac ccgattattg attatgagct gttgaagcac     8160

ttcccaaaaa tcccgacttt gcatgtcgtc ggtacgtcgg attttgtgca tgagtattcg     8220

actatcttgt atgaaaagtt gcaccaaaag gcgccaacat cgacgggatt ggtcactcat     8280

tctaaaggtc atgagattcc gagagatcca aaggttctgg ataaggttgt cgctggcttt     8340

gagaagttga attttgctgt ttctttcagc cattgaggat ccacttaacg ttactgaaat     8400

catcaaacag cttgacgaat ctggatataa gatcgttggt gtcgatgtca gctccggagt     8460

tgagacaaat ggtgttcagg atctcgataa gatacgttca tttgtccaag cagcaaagag     8520

tgccttctag tgatttaata gctccatgtc aacaagaata aaacgcgttt cgggtttacc     8580

tcttccagat acagctcatc tgcaatgcat taatgcattg gacctcgcaa ccctagtacg     8640

cccttcaggc tccggcgaag cagaagaata gcttagcaga gtctattttc attttcggga     8700

gacgagatca agcagatcaa cggtcgtcaa gagacctacg agactgagga atccgctctt     8760

ggctccacgc gactatatat ttgtctctaa ttgtactttg acatgctcct cttctttact     8820

ctgatagctt gactatgaaa attccgtcac cagcccctgg gttcgcaaag ataattgcac     8880

tgtttcttcc ttgaactctc aagcctacag gacacacatt catcgtaggt ataaacctcg     8940

aaaatcattc ctactaagat gggtatacaa tagtaaccat gcatggttgc ctagtgaatg     9000

ctccgtaaca cccaatacgc cggccgaaac ttttttacaa ctctcctatg agtcgtttac     9060

ccagaatgca caggtacact tgtttagagg taatccttct ttctagaagt cctcgtgtac     9120

tgtgtaagcg cccactccac atctccactc gacctgcagg catcgagcct aggctagctc     9180

tagaccacac gtgtgggggc ccgttaacgt taactggttc ccggtcggca tctact         9236


<210>  234
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Thioesterase Ts rv (MoA 1092)

<400>  234
ccagcgacaa ccttatccag aac                                               23


<210>  235
<211>  16644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Polyketide synthase Ts

<400>  235
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgtcacc tcttattcac gatgaccaac cctactcatg gaacgcggct atgccaattg     7620

ccgttgtggg tattggcttc cgcggtcctg gagacgcaac gaatgttgag aatctcttca     7680

gaatgattgc cgaaggcagg gaaagtcgaa ttgatatacc taaggagaaa tggaaccatg     7740

aagcctttta tcatcctgac cccagtcggt ttggaactgt aagttgatca cattcaacat     7800

aaccaattga tatgagaaag cgaggttaat tgaaacagca caatgtcacc ggaggacatt     7860

acttccaaca agatgtctcg cgttttgacg ctccattctt taatatgaca gcagccgagg     7920

ctgccgccct tgatcctcag cagagaatgc ttctagaatg cacatacgaa gccatggaga     7980

actcaggcac caagatgcat gacttcgttg gcagcaatac atccgtcttt gtcggctcgt     8040

tctgcgcaga ttatgctgat gtcctctggc gagaccctga aacggtgccc atgtatcaat     8100

gcaccaatgc tggtcattct cgcgcaaata cggcgaaccg tgtctcatat atttatgatc     8160

tgaaagggcc aagtgtgact gtggatactg cctgttcggc aagtttggtg gctctgcact     8220

taggatgtca gagtttgagg accggtgatg ctaagcaggc tctcgttgcc ggttgcagtg     8280

ccattctaag ccatgaagga atggttacaa tgagtatgat gaggtatgct atcctttgtg     8340

taacatctaa ctttcgatgt gagacccctt gaactttgtg gaaattaacc taatatacct     8400

ccagacttct ctctcccgaa gggcgctgtt acacattcga cgagcgcgca ggaggttatg     8460

cccgaggcga tggtgtcggt gcgatccttt tgaaacctct acaagacgcc ctggatgcgg     8520

gagacacaat tcgggcagtc attcgcggca ctggatcaaa tcaagatggc aaaacgcccg     8580

gaatcaccat gccgagtggc acagcccaag aagctcttgt tcgtagtgtt tatgagaaga     8640

ttggtctcga tcctcttgac acaagctacg ttgagtgtca cggaactggg actcaagctg     8700

gtgaggtcaa tatctcttgt cacggtggaa gtatgctaaa ttcgtttaaa taggcgatgt     8760

cactgagact agcgcccttg ctcgtgtctt tgaacccggt cgaccgaagg atgagccact     8820

ggtaattggc tctgtgaaga ccaatatcgg ccatttggag ggtgcaagtg gtgttgctgg     8880

agtcataaag accattctca tgttagagaa cggccttatt cttcccaaca ggaatttcca     8940

gaaaggaaat ccaaagatct tgtttgacga atggaaatta cgagtatgac ttgactccat     9000

cttgctgttt ttagacatat actgaattcc ttgcaggttc ccttgggagt cgagaattgg     9060

gaaatatcca agcctcgccg agcctctgtg aacagttttg gatacggagg tgccaatgcg     9120

catgtcgtcc ttgagaatgc acaagactac ttgcgaaacc acaactggga attccgatcc     9180

catacgagga aatctgccac tggtgctgtt ttatccaaca gcaagctgac cagtgctgta     9240

gctgctcttg agaccggatc tacgactacc gaaatcataa atactcctag cgaagagtca     9300

tccgggacca gcactccttc aaaccctggt cctcacggcc gcctcttcgt tttctcttca     9360

ttcgacgagg ccactggaaa gaagtacctc cagagtttcg agaagtatat agaagataga     9420

ttgcaaatcg cggactcaga agagttcctc gatgacctcg catatactct gggagagcga     9480

aggacaaatc atacttggcg tacagccgtt ccagcgcagt cagcagagga gcttttgagc     9540

aatttgcgtg aaggtataaa cttgggcaat gctagccaga ctaagaatcg caagattggc     9600

ttcgtgttca ctggccaggg tgcgcagtgg tgtggaatgg gtaaagagtt aattgatcag     9660

tatcctgtct ttaaggagac catcgagaag gctggaattg cgtgtcaaaa agccggcgca     9720

acatttgatc ttgaaagtaa gatgctactc tgcaaatttt ggtttcgatt tatactgatg     9780

gtatgacagc cgagcttcgc aaggacccca aagagtccgc aatcaaccgt gcaatctatt     9840

ctcaaccact ttcaacggct gttcagctgg gtctgattga tctgctggct tcgtggggcg     9900

tgaagcctac ctctgttact ggtcactcca gtggcgaaat tgcttctgcc tatgctgctg     9960

gggctctcag ccttgaggac gccatgttgg tatcctattc tcgtggtgtt gtttccagca    10020

agatggccga gcgtgccacc gtccctggat gcatgatggc aattggtatg tcgaaggagg    10080

aagtgcttcc tattgtttca accctcacga agggcaaagt tgtcgtagca tgctccaaca    10140

gtccttccag cgtgaccgcc tctggtgacc taccggccat tgatgagttg catactgtcc    10200

ttgatgaaaa gggtgtcttt aaccgcaagc tggttgtgga ggttgcctat cattctcacc    10260

acatggagct cgttaaagaa gagtacagga acgccatttc ctctattaag gtccaacccg    10320

gcaatgacgt tgagttcttc tcttctgtta ctggagaacg tgcttcaatc tcgggtcttg    10380

gtcccgatta ctgggtatcc aacatgattg gagaagtcaa gttcaatgat tcacttggtc    10440

gcctgtgctt agagaccgaa ggtccatcag caaccaccaa gaagagtgct caacgtcgca    10500

aagcgaaggt ctctccggtc agcactctga ttgagattgg ccctcattcg gcacttgctg    10560

ggcccatcaa acagatcatc caagcaaatg agaccctcaa caaggcgtct atcaagtact    10620

actctgctct ggtcagaaac aagaacgccg ccactactgt ccttaatcta gtcggtcagc    10680

tcttcgttgc tggacacgag ccaagccttg aaaaggtcaa cagacctaca ggtcttgaaa    10740

gtcactctgt tcttattgac ctgcctccat atgcttggaa tcacgcaaac tcatactggg    10800

cagagtcgcg cattagcaag ttctaccgtg agcgacgctt cccacgaact gacctccttg    10860

gtgttctgga gaggaactcc agctctatag aacctcgctg gcgcaaccat atccgactgt    10920

cagaaatccc ctgggttcgc gatcacaaga ttcaaggtaa cattgtttac ccggcagctg    10980

gatatctcgc catggctatt gaagcagctt gtcagcatgc tattaccgtt aagtccattc    11040

ccacaattac gggttataag cttcgcgagg ttgtaattga ctctgctctc attattccgg    11100

agaatcccgg tgaggtcgaa gttgccatca cattgaagtc attcacggac agtatccgca    11160

atccttcaga tatgtgggac gaatttgtca tttcatcagt caacgccgac agtcgctgga    11220

ctgaacattg tcgtggtctt gtctctgttg tggctccaca aaaggtcgtc aatgtcattg    11280

atggacaggc ccagagtatt gctgaaaagc aagggtatgc cgaactcgtt gccagctatg    11340

aaaccaaatg ccgccgaaac atcaatgttc ctcaattcta tgagcagctt atcgagcttg    11400

gtcttgagta tggaccaaca tttgccaacc tcaagcgagc aaaggcagct cccaatgcgt    11460

gcattggtga tttagagatt ccggataccg ccgctgttat gccatataac ttccagttcc    11520

catttgtcat tcacccagct acgttggatg ccttgttcca tactatcttt gcagccctag    11580

ctactgccaa cggcggcacc ctcaaggatc ctgccgttcc tgtctcggcc agcgaaatct    11640

ttgtttcggc caatattacc tctaagcccg gtgacaagct cgccacttac acatcaactg    11700

agcagaagga ctaccgtttc atgtctgctt ctatgactgt gttccatgag agccaaaagc    11760

aacagggcgc ttttgagccc gttattgaga tcaaggactt gacatgtgcc acacttgctc    11820

gtgaaggggc tgatccttcg acggacggcc aggtaaccaa agcctataac ctagcgtgga    11880

agccaagcat tgacttgctg tcccaatctg aaatcttgga actatgcgct aagacaagtt    11940

ctccagaagg caacaccaat gccacaaatg cgagagagtt gctcgaacgt gctgcctact    12000

acatgctcaa gagggccgtt gcaggctatg cgcctcctga gactaattcc gcttatgcgc    12060

aacaactgtg gtcattcctc aagtcacaga gtagagttgc ttcgtggaaa catgcttacg    12120

acggctggga ccagctattc aaagctgatg ttgacgcatt cattgacaag gtcgtgtctt    12180

catcaagcgt cggcaagttt ctggttgaag ttggcgacaa actacctaac cttgtaaaag    12240

gagagaattc ttctgctgaa tttatcaagg aactagacct caaggtgttc gtggacaata    12300

ctcagttatt ccaaaatacc cagtcagcag cgcggtactt tgacctactt caacacaaaa    12360

cgccgagttt gtctgtcctt gctgttgggc caggatcagg agttgcatct ctgggattcc    12420

tcgctttgct taataaaaag tcatccgctc catttgagcg gtatgagcac aacgacgtcg    12480

agtttgacat cagggacgtc gtcaaagaga agttcccaca gtgggctcaa ctcatcggaa    12540

cgaagcaagt tgacatcagc cgcgaaattc aaggtcagga agatattgag cccaattcgt    12600

acgatgtcct agttgccttc catgtcctcg gggacgcaac tggaatgaat aatgtgcttg    12660

ctcaatccaa gcagcttctc aagccagatg gcaaggtgtt gtttattggg cggcccctga    12720

aatcgcttgt cgcatccgtg cttttcggat acgtgccctc tgttttggca gagactggat    12780

ccacgtctga ccgtagcaat ctgtcgccag cggaaattga cgacatggtc tccgcaagcg    12840

ggtactcaaa ggttacggcc attgctactt ccattaacag caataactac agcatgatgg    12900

ttgtttccgc aagtgcttcc caggatacaa gtgcaaaacc tcagaaggtc catgtcatcg    12960

ccgaggatga gagtactagt cagccgtctc tcctggctgg tctaaaagag gaaggcattg    13020

aggtaacagt ctcttcgctt tcggaagcta gtccaactcc agaccacatg tgcatagtgc    13080

tcagcgatct gtcgaacaag acggtcttgt cggacccatc tgttcaagaa tgggaagcac    13140

tgaagaagat catgctcgaa gccaagggtg tactatgggt aacgcgtggt agtgccgtta    13200

ccacatcaaa ccctaatggt agcatggcta ctggtctgag ccgtacaatt cgctctgaaa    13260

gaggagacgt ccctgttgtc acccttgatc ttgatgctga aagaacactc gatgacgcag    13320

tgtcgaccga tattattttg aaagtcttcc gcaagagttt ctatcccgct ttcactgctt    13380

ccgaagtcga gcaagagtac gcagagcgaa aaggtcgact tttggtgccc cgtttgatcg    13440

aggacgaaga attgaccaag accctcgcta tcgcaacaga gggtgctaag ggtcaactcg    13500

agccccttca tcaacccgga cgtcctctgc gcatgtttgt cggcacacca ggtctcctcg    13560

acagcatttt ctggacggat gatgatcgcg tcgagactcc tttgccggat gactgggttg    13620

agatggaagt caaggcatcc ggcttcaact tcaaggacgt catgatggcc atgggccaga    13680

tcaaagtcga gaacctaggc tgggaatgca gtggtatact aactaaggtt ggtccagcag    13740

tcaccggact tgctgtaggt gatcgagtgg tatgccatgc ctccggaact ttctgtacca    13800

atgcccgagt gcatgtggac aatgtacgaa agatccccga cactatgtcc tttgagattg    13860

cagcatcgct tccagtcact tacgtgactg cataccactc catctacaat atcgctcgcc    13920

tccaaaaggg tgagacaatc ctagtccacg ctgcaaccgg tggtctcggc caagccatta    13980

tcgaattgtg ccaactcata ggcgccgaaa tcttcgctac agtgggcacc ttagacaaga    14040

agaaattcct catagaccac ttccacattc cggaagatca tatcttcttc agtcgtgatc    14100

agagcttcgc cgcgggtata aagcgcatga ctaggggtaa gggtgttgat gcagtcatga    14160

actctcttgc cggtgaagga cttcgtcttt cttgggaatg tattgcaccc tatggccgat    14220

ttgttgagct tggccagcgc gatattggca ttaattcgcg acttgaaatg ggtcaattta    14280

tcaagaacac ttcattcacg gcattcaact tggcttacat ggttcaatat aatcccaagg    14340

tggccaatga agtgtttacg agcgttttaa atctgttctg gaaagatgct atcaagggtc    14400

cttcgccagt tgaggtgtac agtttctcgg acgttgaaaa ggcatttaga agaatgcaga    14460

caggtggcca tatgggtaag ctagttggaa cggctgacac agatgcgatg gtgaaggtga    14520

attgtctctt cttggttgtt gcactatatc atggtctaat gctattttta ggttattcca    14580

cttgacagaa gcaagtccct gctccggtca gatgcctctt acgttcttat tggtggtctc    14640

ggtggtattg gacgagccac tgctctctgg atggttgaac acggtgctcg gaatgttatc    14700

ttcgttaacc gcagtggtgt caaggtcgat gaggctcgag agaccattcg tgtattggag    14760

gagatggagt gcaagactgc aatattcccc tgcgatatca ctaatgaaaa ccaagttgaa    14820

acatttgttg gggatgctgc taaagctatg ccacctatta aaggtgtcat ccagggtgct    14880

atgctactca gggtatgttg tcgaccccta tccattaata ggtgtattga actctaacga    14940

gacataaaaa caggacacac tatttgagaa gatgtctctt gaagactaca ttacggtcct    15000

ccgtcccaag gttcaaggaa catttaatct gcacaagtac ctgccaaaag atatggattt    15060

cttcatcatg gaatcttccg tcagtggcat cgtaggcaat gcctctcaag ctgcctacgc    15120

cgccggaaac acattcctcg atgcatttgc aagctaccgc gtatctcagg gtctgcctgc    15180

cactaccatc gacctgggcg ctatctccgg agtgggatat ctctccacta actcagaact    15240

caaacaagcc atggaacgtc agggattcga attcaccaac cctaagcgtc taatggcgct    15300

catcgagtca gcaattcgta atcctgcacg tcctggtcaa caagctcaca tcattactgg    15360

gcttggaacc tggaacgaag acagttcgct cggagcatta actctaccaa tgttctcgca    15420

ctttcggcac ttaagtgccg gtaacgcaga ctggggcaaa tcaggtagtg gtaacaatct    15480

caaatcggca ctcaaagccg caaagactct tgacgatgca agcgagttaa tcctcggtgc    15540

attgatcgat aagattgctt ctagatccgg cattggtcca gaaaatatta acacttccaa    15600

gtcgatgcct gactatggta ttgactcgct cgttgcggta gagatgagga actggatcac    15660

caaggatatg gatagtacgt tgccagtgct ggaattatta gctagtgacc ccttgacgca    15720

cttggccacc aagatcgcgc agagatcacg ctcagtgcag gttgcagagc aaacgcatga    15780

gtagggatcc acttaacgtt actgaaatca tcaaacagct tgacgaatct ggatataaga    15840

tcgttggtgt cgatgtcagc tccggagttg agacaaatgg tgttcaggat ctcgataaga    15900

tacgttcatt tgtccaagca gcaaagagtg ccttctagtg atttaatagc tccatgtcaa    15960

caagaataaa acgcgtttcg ggtttacctc ttccagatac agctcatctg caatgcatta    16020

atgcattgga cctcgcaacc ctagtacgcc cttcaggctc cggcgaagca gaagaatagc    16080

ttagcagagt ctattttcat tttcgggaga cgagatcaag cagatcaacg gtcgtcaaga    16140

gacctacgag actgaggaat ccgctcttgg ctccacgcga ctatatattt gtctctaatt    16200

gtactttgac atgctcctct tctttactct gatagcttga ctatgaaaat tccgtcacca    16260

gcccctgggt tcgcaaagat aattgcactg tttcttcctt gaactctcaa gcctacagga    16320

cacacattca tcgtaggtat aaacctcgaa aatcattcct actaagatgg gtatacaata    16380

gtaaccatgc atggttgcct agtgaatgct ccgtaacacc caatacgccg gccgaaactt    16440

ttttacaact ctcctatgag tcgtttaccc agaatgcaca ggtacacttg tttagaggta    16500

atccttcttt ctagaagtcc tcgtgtactg tgtaagcgcc cactccacat ctccactcga    16560

cctgcaggca tcgagcctag gctagctcta gaccacacgt gtgggggccc gttaacgtta    16620

actggttccc ggtcggcatc tact                                           16644


<210>  236
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Polyketide synthase Ts rv (MoA 1090)

<400>  236
ttccaccgtg acaagagata ttgac                                             25


<210>  237
<211>  9152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Polyketide cyclase Ts

<400>  237
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgcgtct atcaactctc tcctctctcc ttctaggaag cagcagtatt gtctttgcac     7620

gagtcccacc taccgtcgat aaccaagagc ccatcaaatc gacatcctac ttcctcgacg     7680

atcccgactt cccttcccac ttcgaattcg agaatcccga gacaaactgc aaatacgtct     7740

cgcagccatg gatctacaat gccttcaaca gcgtcagcga ggatatggaa gctgtcttca     7800

aatacgctca tcctgacttg catgttagaa tcatgggcca tcatccgttt gctggatact     7860

accacaatcc taagatggca tttgtcaact cgctttggcg gttgaataat tgcttgaagg     7920

atgccaaggt cgatgcaaaa ctttgggcta ttcacggtgg atgtgatcag gcgtggagcg     7980

tgcaagaatt ctacttcaat gcgactacca acaaaggtga ggaaaccatc tttcactttt     8040

attggaagag caatgctgac aaggacagga caaccatggg aattgacgag tctctgggtc     8100

tcccgctggg acgaggatgg actcattaga gaagtccgca cctgggtcga tgctggccaa     8160

atcatgcgta ctctctggga taatgaaatt tggttcaact cgagcgaccg cgtccatcac     8220

tacgatttca ttcccggtcc tggtggcctt ccgcctattg ctaataaaac tgaattaggg     8280

ggtgaactat aaggatccac ttaacgttac tgaaatcatc aaacagcttg acgaatctgg     8340

atataagatc gttggtgtcg atgtcagctc cggagttgag acaaatggtg ttcaggatct     8400

cgataagata cgttcatttg tccaagcagc aaagagtgcc ttctagtgat ttaatagctc     8460

catgtcaaca agaataaaac gcgtttcggg tttacctctt ccagatacag ctcatctgca     8520

atgcattaat gcattggacc tcgcaaccct agtacgccct tcaggctccg gcgaagcaga     8580

agaatagctt agcagagtct attttcattt tcgggagacg agatcaagca gatcaacggt     8640

cgtcaagaga cctacgagac tgaggaatcc gctcttggct ccacgcgact atatatttgt     8700

ctctaattgt actttgacat gctcctcttc tttactctga tagcttgact atgaaaattc     8760

cgtcaccagc ccctgggttc gcaaagataa ttgcactgtt tcttccttga actctcaagc     8820

ctacaggaca cacattcatc gtaggtataa acctcgaaaa tcattcctac taagatgggt     8880

atacaatagt aaccatgcat ggttgcctag tgaatgctcc gtaacaccca atacgccggc     8940

cgaaactttt ttacaactct cctatgagtc gtttacccag aatgcacagg tacacttgtt     9000

tagaggtaat ccttctttct agaagtcctc gtgtactgtg taagcgccca ctccacatct     9060

ccactcgacc tgcaggcatc gagcctaggc tagctctaga ccacacgtgt gggggcccgt     9120

taacgttaac tggttcccgg tcggcatcta ct                                   9152


<210>  238
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Polyketide cyclase Ts rv (MoA 1089)

<400>  238
cgggaatgaa atcgtagtga tgg                                               23


<210>  239
<211>  9963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9-Citrate synthase Ts

<400>  239
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccatgtcaga cggcaccctt ttcatccaag actctcgtac atccaaacag tataccatct     7620

ccgtgacatc tgatacaata actgctgtgg acttccagaa gatcacctcg ccgacgggaa     7680

agcttgcctt atatgaccca ggcctgcaga atacaattat taagaagact caaattaccg     7740

ggcggtatgt agctggctct actgcacgca ttttgaataa tactaaacgc catttttcta     7800

gtgaccctgt aactggaata acacttttca ggggcctttc agcaaaagag atctggaacc     7860

gccatgctga ttttgaagat catttccatc ttctagtttt tgggaagtat ccctcaccag     7920

aagagagcga ggcgcttcgc cggcgccttg ctgtgcaaat gacagttgtt cctgagaccg     7980

ttatcaaggc ggtgcaggct tttccgtagg tacttccctt cctgcaaata tctggcatca     8040

aagctgatat acccggctcg aagacgtaca tcacatcccc ttcccatgat catcgccggt     8100

ctggccgcat tcatttccgc agatccgtcc tctctaccgg caatccgtgg tggcaatatc     8160

tatcacggca accgcgctct ctgcgatgag ggcgtcattc gagcaacagc cgcttacgca     8220

gttgtcatgg gcctgatcaa ttctcacagg aagcaactcc cttacgtccc agcggacccc     8280

caaaagtcat tctacgaaaa cgtcttcgcc atgatgcgct gtcccgttca ccacaactat     8340

ttggttacgt tccgtgaagg catggtattg aatagtgaca atgggatgac tcagtcgagc     8400

gtcgtcttac tttcaacggc atcttcactt ccagacccaa tctcatgcct cataagtgca     8460

attactgccg cgtatggacc tttacactac ggtgcgcaag aagccggttc cacaacactg     8520

aaatcaatag gatcgttgga taaggtgcca gaattcttgg aacaggtcaa acgacgtgag     8580

agaagattgt tcgggtttgg acaccgacta cacaagcgtg aggatccgcg attagcatcg     8640

gtgaagagat ggttaaagat gatggattac acgccggatc aggaaccgtt gttggaattg     8700

gcgcaagaga tcgacaggct tgcgtcgtcg gatgagtatt ttatcaagag gaatttgagg     8760

gcgaatgcag atttctacac ccatttcttg tttaaagcat ggttcgtatt tgatgttctt     8820

tccatctttt attcaagggt ttaatatgga atgcaggggt ttcgattggg atatgctgtg     8880

tgctgcaaac atgttccaca gaatcattgg tttaatggct cactggcgcg aagctatggg     8940

taagtgttgt cctcccatag tcctcttttg agatagaaac tgacttccta cagatcaacc     9000

gatcaaaatt ttcagggcta cggatctcta tgttggacca gtggtgattc aagaagacaa     9060

tcgtacagtt ctcgaagagc cgaaaattca atccagattg tgaggatcca cttaacgtta     9120

ctgaaatcat caaacagctt gacgaatctg gatataagat cgttggtgtc gatgtcagct     9180

ccggagttga gacaaatggt gttcaggatc tcgataagat acgttcattt gtccaagcag     9240

caaagagtgc cttctagtga tttaatagct ccatgtcaac aagaataaaa cgcgtttcgg     9300

gtttacctct tccagataca gctcatctgc aatgcattaa tgcattggac ctcgcaaccc     9360

tagtacgccc ttcaggctcc ggcgaagcag aagaatagct tagcagagtc tattttcatt     9420

ttcgggagac gagatcaagc agatcaacgg tcgtcaagag acctacgaga ctgaggaatc     9480

cgctcttggc tccacgcgac tatatatttg tctctaattg tactttgaca tgctcctctt     9540

ctttactctg atagcttgac tatgaaaatt ccgtcaccag cccctgggtt cgcaaagata     9600

attgcactgt ttcttccttg aactctcaag cctacaggac acacattcat cgtaggtata     9660

aacctcgaaa atcattccta ctaagatggg tatacaatag taaccatgca tggttgccta     9720

gtgaatgctc cgtaacaccc aatacgccgg ccgaaacttt tttacaactc tcctatgagt     9780

cgtttaccca gaatgcacag gtacacttgt ttagaggtaa tccttctttc tagaagtcct     9840

cgtgtactgt gtaagcgccc actccacatc tccactcgac ctgcaggcat cgagcctagg     9900

ctagctctag accacacgtg tgggggcccg ttaacgttaa ctggttcccg gtcggcatct     9960

act                                                                   9963


<210>  240
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Citrate synthase Ts rv (MoA 1087)

<400>  240
gtcgatctct tgcgccaatt c                                                 21


<210>  241
<211>  8416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pHOFF6 Phsp9

<400>  241
ctattccttt gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc       60

tacacagcca tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt      120

cccggctccg gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa      180

attgccgtca accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg      240

gaggcgcggc gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc      300

catacaagcc aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc      360

gaacatcgcc tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt      420

gttggagccg aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag      480

catcagctca tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg      540

ccagtgatac acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg      600

accgattcct tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc      660

gatcgcatcc atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag      720

gtcttgcaac gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa      780

ctccccaatg tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac      840

ataacgatct ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc      900

tcctacatcg aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga      960

gacgctgtcg aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt     1020

tttcatttgg atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga     1080

agggcgaact taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca     1140

agttatcgtg caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga     1200

gtcacacttc gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa     1260

atgaaccatc ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa     1320

ataggcattc attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat     1380

atcagttaac gggcccgtta acgttaactg gttcccggtc ggcatctact ctattccttt     1440

gccctcggac gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca     1500

tcggtccaga cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg     1560

gatcggacga ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca     1620

accaagctct gatagagttg gtcaagacca atgcggagca tatacgcccg gaggcgcggc     1680

gatcctgcaa gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc     1740

aaccacggcc tccagaagag gatgttggcg acctcgtatt gggaatcccc gaacatcgcc     1800

tcgctccagt caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg     1860

aaatccgcat gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca     1920

tcgagagcct gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac     1980

acatggggat cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct     2040

tgcggtccga atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc     2100

atcgcctccg cgaccggctc gagaacagcg ggcagttcgg tttcaggcag gtcttgcaac     2160

gtgacaccct gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ctccccaatg     2220

tcaagcactt ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct     2280

ttgtagaaac catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg     2340

aagctgaaag cacgagattc ttcgccctcc gagagctgca tcaggtcgga gacgctgtcg     2400

aacttttcga tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatttgg     2460

atgcttgggt agaataggta agtcagattg aatctgaaat aaagggagga agggcgaact     2520

taagaaggta tgaccgggtc gtccacttac cttgcttgac aaacgcacca agttatcgtg     2580

caccaagcag cagatgataa taatgtcctc gttcctgtct gctaataaga gtcacacttc     2640

gagcgccgcc gctactgcta caagtggggc tgatctgacc agttgcctaa atgaaccatc     2700

ttgtcaaacg acacaaattt tgtgctcacc gcctggacga ctaaaccaaa ataggcattc     2760

attgttgacc tccactagct ccagccaagc ccaaaaaatg ctccttcaat atcagttaac     2820

gggcccgagc tcgcggccgc tgtattctat agtgtcacct aaatggccgc acaattcact     2880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     2940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     3000

ttcccaacag ttgcgcagcc tgaatggcga atggaaattg taagcgttaa tattttgtta     3060

aaattcgcgt taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc     3120

aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt tccagtttgg     3180

aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa aaccgtctat     3240

cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg gtcgaggtgc     3300

cgtaaagcac taaatcggaa ccctaaaggg agcccccgat ttagagcttg acggggaaag     3360

ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggcgc tagggcgctg     3420

gcaagtgtag cggtcacgct gcgcgtaacc accacacccg ccgcgcttaa tgcgccgcta     3480

cagggcgcgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     3540

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     3600

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     3660

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     3720

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     3780

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     3840

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     3900

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     3960

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     4020

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     4080

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     4140

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     4200

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     4260

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     4320

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     4380

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     4440

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     4500

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     4560

atcctttttg ataatctcat gaacaataaa actgtctgct tacataaaca gtaatacaag     4620

gggtgttatg agccatattc aacgggaaac gtcttgctct aggccgcgat taaattccaa     4680

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     4740

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     4800

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     4860

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     4920

cactgcgatc cccgggaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     4980

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     5040

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     5100

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     5160

ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     5220

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     5280

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     5340

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     5400

gaataaattg cagtttcatt tgatgctcga tgagtttttc taagaattaa ttcatgacca     5460

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     5520

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     5580

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     5640

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     5700

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     5760

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5820

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5880

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5940

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6000

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6060

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6120

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6180

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6240

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6300

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     6360

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     6420

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     6480

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctctaat     6540

acgactcact atagggaaag ctcggtacca cgcatgctgc agacgcgtta cgtatcggat     6600

cggacaattg tctctatcgt agatgtatct tgtaaagtcg tctgcgatgc cttcgagggg     6660

cggagactct aaaagagaat caagagataa gaagattgaa aagtatcaga tcgagaacta     6720

cagaaagtga tgtgaacaat gagagcacaa tcaaacacgg aaggctgaat agcatggctg     6780

tcgatgtgac tcgacagata aaatggtggt catgaaggca tagaccgtag gacgagtggt     6840

tgatacagaa gaggagagcc agcggtgagt cggcggtggc gtggacgtcg gtgactcgac     6900

gggataagcc ctgctcaccg ctttcctctt ttgacgtcgc cgagaacgct cgaccgatct     6960

ggcaaggtct gatctcggcc ggagtaataa attatccgca atcccaagtc atgtgatgcg     7020

ccaaggccct tgcctgcttc aggttaggct gtggcttgca tctcagcagg gaagcgccac     7080

agatctaagg atcatcgcga cgtcatggat ggtgacatcg acgaggaaga cgcgttcagt     7140

cttgtttctc aagccacaat gatccctgct ggggtctgga acgtcagcca aggctccgat     7200

gtgatcaagc gcggggacac gaatctccac tcttgattca atggcactat tttccagccc     7260

tgatatccag tcgttcaagt gtggggacgc tcaaggtagg ataatgtagg ataacgtacc     7320

taggatacca gtttccttgt atgtatgtcc tgcaagtaat tactcgtgta tttaccatgt     7380

gctcctgaat cgacgtcatg gactgaggga gagatgtgaa atccgtggta tataaacctc     7440

cacgatcttc cagctttctg catacaacag caatctccat ctcaaacact taaccactct     7500

ctcgaagata actactcttt tcaaaccaaa acttcttcat tcaaacaact gcaaacggat     7560

ccacttaacg ttactgaaat catcaaacag cttgacgaat ctggatataa gatcgttggt     7620

gtcgatgtca gctccggagt tgagacaaat ggtgttcagg atctcgataa gatacgttca     7680

tttgtccaag cagcaaagag tgccttctag tgatttaata gctccatgtc aacaagaata     7740

aaacgcgttt cgggtttacc tcttccagat acagctcatc tgcaatgcat taatgcattg     7800

gacctcgcaa ccctagtacg cccttcaggc tccggcgaag cagaagaata gcttagcaga     7860

gtctattttc attttcggga gacgagatca agcagatcaa cggtcgtcaa gagacctacg     7920

agactgagga atccgctctt ggctccacgc gactatatat ttgtctctaa ttgtactttg     7980

acatgctcct cttctttact ctgatagctt gactatgaaa attccgtcac cagcccctgg     8040

gttcgcaaag ataattgcac tgtttcttcc ttgaactctc aagcctacag gacacacatt     8100

catcgtaggt ataaacctcg aaaatcattc ctactaagat gggtatacaa tagtaaccat     8160

gcatggttgc ctagtgaatg ctccgtaaca cccaatacgc cggccgaaac ttttttacaa     8220

ctctcctatg agtcgtttac ccagaatgca caggtacact tgtttagagg taatccttct     8280

ttctagaagt cctcgtgtac tgtgtaagcg cccactccac atctccactc gacctgcagg     8340

catcgagcct aggctagctc tagaccacac gtgtgggggc ccgttaacgt taactggttc     8400

ccggtcggca tctact                                                     8416


<210>  242
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer TtrpC rv (MoA 800

<400>  242
caagagcgga ttcctcagtc                                                   20


<210>  243
<211>  7467
<212>  DNA
<213>  Bipolaris maydis

<400>  243
atggcaccct ttctagatga taacctgggc gctagcagcg gcatcaatca caatggcaaa       60

gaagatggat caatgcccat agcgatcgtg ggcatgtcat ttcgaggccc tggatcagca      120

aacaacatag agaacctctt caaaatgatc tgcgagaaaa gggaatcacg aacagcgatt      180

cccaagtcca gatggaacaa caaggcattc tatcacccca atttccaacg tcatgggtcc      240

cacaatgttg agtatgggca tttttttcat gatgatatct ctaagtttga cgccccgttc      300

ttcaacatga caaaggaaga ggctgctgca ctcgatccag cacaacgact gcttctagaa      360

agcacgtatg aagcactgga gaacggtaag agcaatgcaa tcataagtgg aaagcaaatt      420

tgacttagtt cataggtggc atacctttgg agaagattgt gggaacgaaa acgtctgtct      480

tcgtcggctc cttcgctaca gattacacgg accttttaac tcgagatcca gaatctgtgc      540

caatgtacca gtgcaccaat agtggacaat ctcgtgcaat gatttccaat aggttgtctt      600

acttctttga ccttcacggc ccaagcgtca cagttgatac agcatgttct ggaagtttgg      660

tagcgctaca tttggcttgc cagagtctcc gggcaggaga ggccaagtca gcaattgctg      720

ctggtgtaaa tgtagtcttg aaccatgaat tcatgaccac aatgagcatg atgaagtaag      780

tccagctgga aaagtaattt taacgtccat acacatactc ataaggatag attcctgtcg      840

cctgatggcc gctgctatgc attcgacgag cgtgggaacg gttatgggcg cggtgaaggt      900

gtaggaactg tcttcctaaa accacttgct gatgctttga aggatggcga tccgatccga      960

gctgtcattc gaggatcggc ttcgaatcag gatggtaaaa catctggtat cacactaccc     1020

aacccagtag cccaagaagc tctgatcaaa gatgtgtatc atgtcgccga ccttaatcca     1080

attgacacta gcattgtgga agcgcacggt actggtaccg ctgctggaga ccctctagaa     1140

ctgcgggcct tgactaattc gttctgcggc gccaatcgtc ctgaggatcg tcctctcata     1200

ataggatcta tcaaatccaa ccttggtcat ctagaaggag ctagtggtat tgctgctgta     1260

gtcaaggctg tcttaatgct ggaacaggaa gtcatattac caaaccaaaa tttcgaaaaa     1320

ccaaacccta ggattccctt tgtggattgg aaactgcgtg tcgctacaaa tgtacaaccg     1380

tgggattcgt caggaccact acgcgtatcg attaatagtt tcggatacgg tggttccaat     1440

gctcatgtta ttctggagtc gacacgaaca tatctgactt cacgaggtct ttccaacgcc     1500

caaaaacact caacacattt tctgcgttac aagtatggag cagtaaatac tactcccaag     1560

ccagttaatg aattcattca tgagaatgga gcttcgccta ttgattctcc ggtgccaaat     1620

tacagtcatc cgaagctttt cacactgagt gtctttgatg agcctacggc tcaacaacaa     1680

atccagactt tagtcaaaca tcttcacgag cgcggcatat acaaccactc tggcttcctg     1740

gacgatcttg ccttcacttt gaatgaaaga agaacaaaat ttatttggaa agctgcagtg     1800

gttgcagcat ctcccaagga attaatcgac gctctttcca agcctataaa gttttcacgc     1860

tctataaaat ctgccacttt agggttcgtc ttcaccggac agggagctca atggtgtggg     1920

atggccaaag agcttctaga agtgtatcca gtgttcaaaa ccacaattcg cagaattgga     1980

aaatacctgc attcgattgg ggcacctttc gacgtcgaag aggagatcaa gatggaccca     2040

aaggtatcta agattaacaa agcgctgtac agtcaaccaa tgtgttctgc agttcagata     2100

gctttggttg agctgctcgc ttcttggaac atcagaccta catcagtgac cggtcattcg     2160

agtggagaga tagcgtcggc atatgcaata ggtgcgctga gtctagaaga tgcaatgact     2220

gctgcatatt atcgcggcgt ttcttctact aggatgcaag aagagcataa agctaacggg     2280

gcaatgatgg cagccggact atccgaggaa gacgcaacaa gattccttgc cgaactcaag     2340

tctggtaagg ctgtcgtggc atgctcaaac agcccctcta gcgtcactat ctctggagat     2400

gtatccgcag ttagcgaatt acaaaaaatc ttggagtcca aaggcatatt cgcgcgaatg     2460

cttgctgtcg aagttgctta ccattcgcac catatggagc ttgtcgcaga agattatgca     2520

aaagctattg cgggcatacg aacacgacag ggtaacggag tgaaattcta ctcgtcggta     2580

tacggccgag agatcggtgc ggatgacctt ggtccaagct actgggtgaa gaatttgctc     2640

tgccaagtaa agtttacgga tgcgatgcgt caactatgct tagctcctgc tattcaaagt     2700

aaaagacgac aagccaagag acataacgta gacttcttgg tggagattgg gcctcattca     2760

gctctcgctg ggcctatcaa ggagataatc cagagcgatc caaagttgag agttgcagac     2820

atcatgtacg cttcagccct agtgcgaaag gtggatgctg tacggactgt tctcgatttg     2880

gctgggaaac tgtcagcgat aggatatcag gtcaactatg cggcgatgaa tcggcccaca     2940

gcagatcata atgccagcgt cttggttgat ctaccgtctt acacttggaa tcactccaca     3000

tcatactggg ccgagccgcg ccgcagcaaa gcatttcgga acaggatttt cccaagggta     3060

gacatactgg gagtgcgcga cgagaactca gatcctttgc agttgagctg gcgcaaccat     3120

cttcgcactt cagagatacc atggctcttg caacacaaga ttcagtccag cgtagtcttt     3180

ccagcagcag gtttcattgc tatggctatc gaagcggctg ctcagcggtc aaaggaaaga     3240

ttcgccaaga aaatttccgg ctaccagctt cgtgaagtca acattggaac tgcgcttctt     3300

ttgcctgagc aagaatccgt agagacaata ctgaccttga agccgattcg agatagttcc     3360

aaacgccact ccgatacctg gagtgagttt cacatatatt cagtaacaaa cgacaaccac     3420

tggacggaac attgtcacgg actgatttac gtgcagcacc agaaacagca agagagtagc     3480

agagaaactc acctcactat tcagccagca gtagaggagt ttcggaccac ccttccaatg     3540

ccagagtttt atgagcatct gtctagtatt ggtcttgagt atggcgaggt tttccaaaat     3600

ctaattgagg ctcgctcttc tccagataaa ctgactggag tcctgaagct acctgcaacg     3660

gcgactgcca tgcctttgga tcaagaacac acttatgtga tacacccagc tactctagac     3720

gctatcctgc atacggtatt tggtgctctt tctgccgaca actggctcca ggactctgct     3780

atcccggttt tcgtgtcgaa tttgttcatc tccgcggaca tgcctttcca agccggccat     3840

cttcttaagg ccaatgctat catctcagca cgagacaacc aaacgatgaa aacagatatt     3900

atagttatag atgatagcaa aaatgcgcca gtggtacaat tttccgagct ggattggagg     3960

tttctcccaa gaccgatcga acaagaagac attgctgaca accatcacgt cgcctacaca     4020

ctcgattggg aagcagacgt cgaattccta gacctaaaaa atactcaaca aatacctcat     4080

tctgctgcag attacttacg cctactgggt tttaagaatc ccgaaatctc tgtattggat     4140

gtatctgcat ctagcagctc catactttct ttcttgaagg cgttagagat tggaaacagc     4200

gctgcaaaac aaagatgcag agcttacaca gtagcacatc ctcaaagaaa caaagcggcc     4260

ctcgtcagcg atgtgccaga tctcccttac gacttggtca ccaagaaagc gctagatcta     4320

gagattggtc ctcagacgcc ggattttgag ttgaagtcat ttgacgtcat cattgtgtcc     4380

gcttcattag cagatttcaa caacccgcat aaagctttag gtcatatcaa aagtttatta     4440

agaccggatg gcaggcttat cgtgcttcat gagggtacaa tggaccaaga tccagtcttc     4500

ctacaatgga aaacatcctt acagcaagct ggctttatgg atcacaagct cattgaatca     4560

gatgattcgg gtgaaagggt agaccaaggc tcgctcttcg tggctcatcc aaatcaagaa     4620

tccaaccctg ctactcccga aatcatagtc atggccgaag accacaatca aactattgac     4680

acgagtcatc tggccagtct cttaggctta gagcccggaa atattgagca aagttccata     4740

tatgatgtcg cacctaccga gaaaatactc attgtgtggg atgcttctgg agaactgctg     4800

agcagtcctt caattgagca gtttgaggct atcaagcgga ttttcactca gagcaacaag     4860

ttactctggg tgacttcagg caggggtcaa ggctctcgtc gcccagaatc caacatgatc     4920

actggactag ctaggacggc aaggactgag aatggtgcag caaaactggt cactttggac     4980

cttgacgacg aagacaagct gtcgcggaat gatgccacaa acgttatctc tgccattctc     5040

aaacgttcat tcttaggaaa tgaacaacag catatggctg agagcgagta tgttgagagg     5100

aaaggcatca tcactattcc tcggctctcg gtggacgaca cactgaatca ggcgcttgac     5160

tcctatctca atcccacagc caaagaggtc caactactgc atcacaaggg tatcgtcttt     5220

agtcttcttg atcgctctga ttctcgtaag ccgttttctt tccaggagat tgcctttgac     5280

gatgaactgg aagagaatga gattcggatc gaggtaaagg caatgacgct ggtctctgga     5340

aacagagtga acattctcac ccaagacatt agcggagtgg ttgtaaaagt cggcgaccaa     5400

gtatcaggct tgttgccggg tgatcgtgtc ttcggctccg tatctaatcg cgtctcaaac     5460

tcatacaaag gaagagcaag cgctttccag aagatacccg acggagtacc tttcgaaatt     5520

gcagcctcat acccaactgc ttacagcaca gcatattatg caatgtaccg cctcgcccat     5580

gtttccaagg ccgacaacgt tttcgtttca tcagctgcga cccctgttgg tcgagccttg     5640

atagacctct gtggcagaat tggtgccaaa gtgtatgttg gagtgagtac tgacaaagag     5700

gcgtttttca tggaatctgc cctccacttc cccaaggatc aaatcattta caacaatgaa     5760

gagcgctcgg ttgcagcgtt gattgcaaac acgcaaggcc atggaatgga tgtgattttc     5820

aattcgcttg ctggagagat cctgcaaacg tgttggaact gcatagcacc atacggtcgg     5880

tttatcgagc tcggtactca ggacctcatc gaaaattcac gcttggagat ggcaaacttt     5940

aggaagaata cgagttttag cgcgctgaac ctttctcgcc tccaggaaga acgaccagcc     6000

ttggcggacg agatatgggg gcagactatg gaactcatat cgaaagactc atttagcagt     6060

acggtgccca atctgcagct tttcaatggc gaggggataa gccaggcatt tgaacgcttg     6120

atggacgaag agaataccga ccatgtggtt cttaccttta accccagtga tcgagtcatg     6180

gttagtgcgc attgagatga aactgctttt ttttctggag cttacattat caggtccttc     6240

ctaccactag caaagatcaa ctattccgcg ctgacgcgtc ttatctactt gtcggtggac     6300

taggtggcat aggacgggca acggcgtcgt ggatggttga gcatggggct aagaacctca     6360

tctttgcaaa ccgaagcggt atgtctaaac aggaagccag agctacggtt catgctttga     6420

aatctatggg cgctcgagtg catgttcaga aatgcgatgt aagcgacgcc gagcatgtcc     6480

gccaactggt tgaagagtgt gggagtcaaa tgccacccat tcgtggtgtg attcaaggtg     6540

caatggtatt acaagtgttt atttcttcgc ctggctgctc gtactaaatc aagacaggat     6600

atgctattag aaaaactcac tgtggacgat tggaatgctg ttgttcgtcc caaagtacat     6660

ggaacatgga acctgcataa tcatctgccg aaagacatgg atttcttcat tatgctatcc     6720

tccatcagtg gtatcatcgg aaacactacg caagctgctt atgctgcagg gaacaccttt     6780

ttggatgcct tttccggatt ccgcaatgcc caagggctcc ctgctgttac tttggacttg     6840

ggtgcaatct caggaatcgg atacctcgct tcggaagaaa acaaacaatt gtccaagtcc     6900

atgcaagatc aaggcttcag tatgacgggc gaaaagctac tcctcgcgct catacgatcc     6960

gcaattgtag agcctttcgg acgaggaggc aaaacacaga ctgtaaccgg actgggcacg     7020

tggagaagcg gccgatcctt atctgcgttg gagaattcca tgttttcgca ttatcgtcgg     7080

cattcgaaag aagccgaagt cattgcggag aaagagcaga cgtcaaacgg caagatatct     7140

gtcaaagacg ctctgcgatc ttcagaatcc gtagatgatg cagctggtgt tatctgcaat     7200

ggactgcttg ggtacctagc aagcagatcc ggcgtatctg tggagaactt cagttccgaa     7260

atgtctctta cagaatgtgg cgtagattcc attgttgcag tcgacgtgcg aaactggatt     7320

gcacgagagt tggaaagttc cataccactt ttggagctac ttgcaaacca cccgttgtcg     7380

caactgagcg tggatattgc ttcgcgctcg aaattagtgc cagttgagat caagtcacgc     7440

ggagctgcgg ctacagcatc cgcgtag                                         7467


<210>  244
<211>  2421
<212>  PRT
<213>  Bipolaris maydis

<400>  244

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Lys 
        35                  40                  45              


Met Ile Cys Glu Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Arg His Gly Ser 
65                  70                  75                  80  


His Asn Val Glu Tyr Gly His Phe Phe His Asp Asp Ile Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Glu Lys Ile Val Gly Thr Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Phe Ala Thr Asp Tyr Thr Asp Leu Leu Thr Arg Asp Pro 
145                 150                 155                 160 


Glu Ser Val Pro Met Tyr Gln Cys Thr Asn Ser Gly Gln Ser Arg Ala 
                165                 170                 175     


Met Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Val Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Val Leu Asn His Glu Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Arg Pro Glu Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Phe Val Asp Trp Lys 
                405                 410                 415     


Leu Arg Val Ala Thr Asn Val Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Gly Leu Ser Asn 
    450                 455                 460                 


Ala Gln Lys His Ser Thr His Phe Leu Arg Tyr Lys Tyr Gly Ala Val 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Val Asn Glu Phe Ile His Glu Asn Gly Ala 
                485                 490                 495     


Ser Pro Ile Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Thr 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Gly Ile Tyr Asn His Ser Gly Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ala Phe Thr Leu Asn Glu Arg Arg Thr Lys Phe Ile 
545                 550                 555                 560 


Trp Lys Ala Ala Val Val Ala Ala Ser Pro Lys Glu Leu Ile Asp Ala 
                565                 570                 575     


Leu Ser Lys Pro Ile Lys Phe Ser Arg Ser Ile Lys Ser Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Lys 
        595                 600                 605             


Glu Leu Leu Glu Val Tyr Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Tyr Leu His Ser Ile Gly Ala Pro Phe Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Lys Met Asp Pro Lys Val Ser Lys Ile Asn Lys Ala Leu Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Val Ser Ser Thr Arg Met Gln Glu Glu 
705                 710                 715                 720 


His Lys Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Thr Arg Phe Leu Ala Glu Leu Lys Ser Gly Lys Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Ile Leu Glu Ser Lys Gly Ile Phe Ala Arg 
    770                 775                 780                 


Met Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Ala Glu Asp Tyr Ala Lys Ala Ile Ala Gly Ile Arg Thr Arg Gln Gly 
                805                 810                 815     


Asn Gly Val Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Ile Gly Ala 
            820                 825                 830         


Asp Asp Leu Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Asp Ala Met Arg Gln Leu Cys Leu Ala Pro Ala Ile Gln 
    850                 855                 860                 


Ser Lys Arg Arg Gln Ala Lys Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Lys Glu Ile Ile Gln 
                885                 890                 895     


Ser Asp Pro Lys Leu Arg Val Ala Asp Ile Met Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Lys Val Asp Ala Val Arg Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Ile Gly Tyr Gln Val Asn Tyr Ala Ala Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Ala Ser Val Leu Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Arg Arg Ser Lys Ala 
                965                 970                 975     


Phe Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Val Arg Asp 
            980                 985                 990         


Glu Asn Ser Asp Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Ile Pro Trp Leu Leu  Gln His Lys Ile Gln  Ser Ser Val 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Phe Ala Lys Lys Ile  Ser Gly Tyr 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Thr Ala Leu Leu  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Val Glu Thr Ile  Leu Thr Leu Lys Pro  Ile Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Ser Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Val  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Val Gln His Gln Lys  Gln Gln Glu Ser Ser  Arg Glu Thr 
    1115                 1120                 1125             


His Leu  Thr Ile Gln Pro Ala  Val Glu Glu Phe Arg  Thr Thr Leu 
    1130                 1135                 1140             


Pro Met  Pro Glu Phe Tyr Glu  His Leu Ser Ser Ile  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Tyr Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Val Phe Gly Ala Leu  Ser Ala Asp 
    1205                 1210                 1215             


Asn Trp  Leu Gln Asp Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Met Pro  Phe Gln Ala Gly His  Leu Leu Lys 
    1235                 1240                 1245             


Ala Asn  Ala Ile Ile Ser Ala  Arg Asp Asn Gln Thr  Met Lys Thr 
    1250                 1255                 1260             


Asp Ile  Ile Val Ile Asp Asp  Ser Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Leu Pro Arg Pro  Ile Glu Gln 
    1280                 1285                 1290             


Glu Asp  Ile Ala Asp Asn His  His Val Ala Tyr Thr  Leu Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Glu Phe Leu  Asp Leu Lys Asn Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Tyr  Leu Arg Leu Leu Gly  Phe Lys Asn 
    1325                 1330                 1335             


Pro Glu  Ile Ser Val Leu Asp  Val Ser Ala Ser Ser  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Glu Ile Gly Asn Ser  Ala Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Lys 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Val  Pro Asp Leu Pro Tyr  Asp Leu Val 
    1385                 1390                 1395             


Thr Lys  Lys Ala Leu Asp Leu  Glu Ile Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Lys Ser 
    1430                 1435                 1440             


Leu Leu  Arg Pro Asp Gly Arg  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Asp  Gln Asp Pro Val Phe  Leu Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Lys Leu Ile Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Glu  Arg Val Asp Gln Gly  Ser Leu Phe Val Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Ser Asn Pro Ala Thr  Pro Glu Ile Ile Val  Met Ala Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Ile Asp  Thr Ser His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Gly Leu  Glu Pro Gly Asn Ile  Glu Gln Ser Ser Ile  Tyr Asp Val 
    1535                 1540                 1545             


Ala Pro  Thr Glu Lys Ile Leu  Ile Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Leu Leu  Ser Ser Pro Ser Ile  Glu Gln Phe Glu Ala  Ile Lys Arg 
    1565                 1570                 1575             


Ile Phe  Thr Gln Ser Asn Lys  Leu Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Gly Gln  Gly Ser Arg Arg Pro  Glu Ser Asn Met Ile  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Thr Glu  Asn Gly Ala Ala Lys  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Asp  Lys Leu Ser Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Ile Leu  Lys Arg Ser Phe Leu  Gly Asn Glu 
    1640                 1645                 1650             


Gln Gln  His Met Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Ile 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Thr Leu  Asn Gln Ala 
    1670                 1675                 1680             


Leu Asp  Ser Tyr Leu Asn Pro  Thr Ala Lys Glu Val  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Gly Ile Val Phe  Ser Leu Leu Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Ile Ala Phe Asp  Asp Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Glu Ile Arg Ile  Glu Val Lys Ala Met  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Asn Ile  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Asp Gln  Val Ser Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Arg Val Ser Asn  Ser Tyr Lys 
    1775                 1780                 1785             


Gly Arg  Ala Ser Ala Phe Gln  Lys Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Leu Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Ile Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Glu  Glu Arg Ser Val Ala  Ala Leu Ile 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Ile Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Ile  Glu Asn Ser 
    1925                 1930                 1935             


Arg Leu  Glu Met Ala Asn Phe  Arg Lys Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Glu Glu Arg Pro Ala  Leu Ala Asp 
    1955                 1960                 1965             


Glu Ile  Trp Gly Gln Thr Met  Glu Leu Ile Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Leu  Gln Leu Phe Asn Gly  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Phe Asn Pro  Ser Asp Arg Val Met  Val Leu Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Asp Gln Leu  Phe Arg Ala Asp Ala  Ser Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Lys  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Met  Ser Lys Gln Glu Ala  Arg Ala Thr Val His  Ala Leu Lys 
    2075                 2080                 2085             


Ser Met  Gly Ala Arg Val His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Arg Gln Leu  Val Glu Glu Cys Gly  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Leu Thr  Val Asp Asp Trp Asn  Ala Val Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Trp Asn Leu His Asn  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Phe Phe Ile  Met Leu Ser Ser Ile  Ser Gly Ile 
    2165                 2170                 2175             


Ile Gly  Asn Thr Thr Gln Ala  Ala Tyr Ala Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Asp  Ala Phe Ser Gly Phe  Arg Asn Ala Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Val Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Tyr Leu Ala 
    2210                 2215                 2220             


Ser Glu  Glu Asn Lys Gln Leu  Ser Lys Ser Met Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Ser  Met Thr Gly Glu Lys  Leu Leu Leu Ala Leu  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Arg Gly Gly Lys Thr  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Leu Gly Thr Trp Arg  Ser Gly Arg Ser Leu  Ser Ala Leu 
    2270                 2275                 2280             


Glu Asn  Ser Met Phe Ser His  Tyr Arg Arg His Ser  Lys Glu Ala 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Glu  Gln Thr Ser Asn Gly  Lys Ile Ser 
    2300                 2305                 2310             


Val Lys  Asp Ala Leu Arg Ser  Ser Glu Ser Val Asp  Asp Ala Ala 
    2315                 2320                 2325             


Gly Val  Ile Cys Asn Gly Leu  Leu Gly Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Gly Val  Ser Val Glu Asn Phe  Ser Ser Glu Met Ser  Leu Thr Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Ser  Ile Pro Leu Leu Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Val Asp Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Lys Leu  Val Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  245
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  245

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Glu Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Arg 
        35                  40                  45              


Met Ile Cys Glu Lys Lys Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Tyr Tyr His Pro Asn Phe Gln Arg His Gly Ser 
65                  70                  75                  80  


His Asn Val Asp Tyr Gly His Phe Phe His Asp Asp Ile Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Val Pro Leu Glu Lys Ile Val Gly Ser Arg Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Phe Gly Ser Asp Tyr Thr Glu Leu Leu Thr Lys Asp Pro 
145                 150                 155                 160 


Glu Ser Val Pro Met Tyr Gln Cys Thr Asn Ser Gly Gln Ser Arg Ala 
                165                 170                 175     


Met Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Met Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Thr Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Met Leu Asn His Glu Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Lys Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Val Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Arg Pro Glu Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Phe Val Asp Trp Lys 
                405                 410                 415     


Leu Arg Val Ala Thr Asn Val Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Gly Leu Ser Gln 
    450                 455                 460                 


Ala Asn Lys His Ser Thr His Phe Leu Arg Tyr Lys Tyr Gly Ala Val 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Val Asn Glu Phe Ile His Glu Gln Gly Ala 
                485                 490                 495     


Ser Pro Ile Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Thr 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Gly Ile Tyr Asn His Ser Gly Phe 
    530                 535                 540                 


Leu Glu Asp Leu Ala Phe Thr Leu Asn Glu Arg Arg Ser Lys Phe Ile 
545                 550                 555                 560 


Trp Lys Ala Ala Val Val Ala Ala Ser Pro Lys Asp Leu Ile Asp Ala 
                565                 570                 575     


Leu Ser Lys Pro Ile Lys Phe Ser Lys Ser Ile Lys Ser Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Arg 
        595                 600                 605             


Asp Leu Ile Glu Val Tyr Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Ala Arg Tyr Leu His Ser Leu Gly Ala Pro Trp Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Arg Met Asp Pro Lys Val Ser Arg Ile Asn Lys Ala Leu Phe Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Lys Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Val Ser Ser Thr Arg Met Gln Glu Glu 
705                 710                 715                 720 


His Lys Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Thr Arg Phe Leu Ala Glu Leu Lys Ser Gly Lys Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Ile Leu Glu Thr Lys Gly Ile Phe Ala Arg 
    770                 775                 780                 


Leu Leu Ala Val Glu Val Ala Tyr His Ser His His Met Asp Leu Val 
785                 790                 795                 800 


Gly Glu Asp Tyr Ala Lys Ala Ile Ala Gly Leu Arg Thr Arg Gln Gly 
                805                 810                 815     


Asn Gly Val Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Ile Gly Ala 
            820                 825                 830         


Asp Asp Leu Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Asp Ala Met Arg Gln Leu Cys Leu Gly Pro Ala Ile Gln 
    850                 855                 860                 


Ser Arg Arg Arg Gln Ala Lys Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Lys Glu Ile Ile Gln 
                885                 890                 895     


Ser Asp Pro Lys Leu Arg Val Ala Asp Ile Met Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Lys Val Asp Ala Val Arg Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Ile Gly Tyr Gln Val Asn Tyr Ala Ala Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Ala Ser Val Leu Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Arg Arg Ser Lys Ala 
                965                 970                 975     


Trp Arg Asn Arg Ile Phe Pro Lys Val Asp Ile Leu Gly Val Arg Asp 
            980                 985                 990         


Glu Asn Ser Asp Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Ile Pro Trp Leu Leu  Gln His Arg Ile Gln  Ser Ser Val 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Phe Ala Lys Lys Ile  Ser Ala Tyr 
    1040                 1045                 1050             


Gln Leu  Lys Glu Val Asn Ile  Gly Thr Ala Leu Leu  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Val Glu Thr Ile  Leu Thr Leu Arg Pro  Ile Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Ser Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Ile  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Leu Asn His Gln Lys  Gln Gln Glu Ser Ser  Arg Glu Thr 
    1115                 1120                 1125             


His Leu  Thr Ile Asn Pro Ala  Val Glu Glu Phe Arg  Thr Thr Leu 
    1130                 1135                 1140             


Pro Met  Pro Asp Phe Tyr Asp  His Leu Ser Ser Ile  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Phe Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Leu Leu His Thr  Ile Phe Ala Ala Val  Ser Gly Asp 
    1205                 1210                 1215             


Asn Trp  Leu Gln Glu Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Met Pro  Phe Gln Ala Gly His  Leu Leu Lys 
    1235                 1240                 1245             


Ala Asn  Ala Ile Val Ser Ala  Arg Asp Asn Gln Thr  Ile Lys Thr 
    1250                 1255                 1260             


Asp Val  Val Val Ile Asp Glu  Ser Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Leu Pro Arg Pro  Ile Glu Gln 
    1280                 1285                 1290             


Glu Asp  Ile Ala Asp Asn His  His Leu Ala Tyr Thr  Leu Glu Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Glu Phe Leu  Asp Leu Lys Asn Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Phe  Leu Arg Leu Leu Gly  Phe Lys Asn 
    1325                 1330                 1335             


Pro Glu  Ile Ser Val Leu Asp  Val Ser Ala Ser Ser  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Glu Val Gly Asn Ser  Gly Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Lys 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Val  Pro Asp Ile Pro Tyr  Asp Leu Ile 
    1385                 1390                 1395             


Thr Lys  Arg Ala Leu Asp Leu  Glu Ile Gly Pro Gln  Ser Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Lys Ser 
    1430                 1435                 1440             


Leu Leu  Arg Pro Asp Gly Arg  Leu Ile Val Leu His  Glu Gly Ser 
    1445                 1450                 1455             


Met Asp  Gln Asp Pro Val Phe  Leu Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Asn Ala  Gly Phe Met Asp His  Lys Leu Ile Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Glu  Arg Val Asp Asn Gly  Thr Leu Phe Val Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Ser Asn Pro Ala Thr  Pro Glu Ile Ile Val  Met Ala Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Val Asp  Thr Ser His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Gly Leu  Glu Pro Gly Asn Ile  Glu Gln Ser Ser Ile  Tyr Asp Val 
    1535                 1540                 1545             


Ala Pro  Thr Asp Lys Ile Leu  Ile Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Leu Leu  Ser Ser Pro Ser Ile  Glu Gln Phe Asp Ala  Ile Lys Arg 
    1565                 1570                 1575             


Ile Phe  Thr Gln Ser Asn Lys  Leu Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Gly Gln  Gly Ser Arg Arg Pro  Asp Ser Asn Met Ile  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Ser Glu  Asn Gly Gly Ala Arg  Leu Val Ser 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Asp  Lys Leu Ser Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Leu  Ile Ser Ala Ile Leu  Lys Arg Ser Phe Leu  Gly Asn Glu 
    1640                 1645                 1650             


Gln Gln  His Met Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Ile 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Thr Met  Asn Asn Ala 
    1670                 1675                 1680             


Leu Asp  Ser Tyr Leu Asn Pro  Thr Ala Lys Glu Val  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Gly Ile Val Phe  Ser Leu Leu Asp Arg  Ser Asp Thr 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Ile Ala Phe Asp  Asp Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Glu Ile Arg Ile  Glu Val Lys Ala Met  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Ile Asn Ile  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Leu  Lys Val Gly Asp Gln  Val Ser Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Arg Val Ser Asn  Ser Tyr Lys 
    1775                 1780                 1785             


Gly Arg  Ala Ser Ala Phe Gln  Lys Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Leu Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Leu Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Glu  Glu Arg Ser Val Ala  Ala Leu Ile 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Leu Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Ile  Glu Asn Ser 
    1925                 1930                 1935             


Lys Leu  Glu Met Ala Asn Phe  Arg Lys Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Glu Glu Arg Pro Ala  Leu Ala Asp 
    1955                 1960                 1965             


Glu Ile  Trp Gly Gln Thr Met  Asp Leu Ile Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Ile Pro Asn Leu  Gln Leu Phe Asn Gly  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Phe Asn Pro  Ser Asp Arg Val Met  Val Leu Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Asp Gln Leu  Phe Arg Ala Asp Ala  Ser Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Lys  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Leu  Ser Lys Gln Glu Ala  Arg Ala Thr Val His  Ala Leu Lys 
    2075                 2080                 2085             


Ser Met  Gly Ala Arg Val His  Ile Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Arg Gln Val  Val Glu Glu Cys Gly  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Leu Thr  Val Asp Asp Trp Asn  Ala Met Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Phe Asn Leu His Gln  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Phe Phe Ile  Met Leu Ser Ser Ile  Ser Gly Ile 
    2165                 2170                 2175             


Ile Gly  Asn Thr Thr Gln Ala  Ala Tyr Ala Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Asp  Gly Phe Ser Gly Phe  Arg Asn Ala Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Met Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Tyr Leu Ala 
    2210                 2215                 2220             


Ser Glu  Glu Asn Lys Gln Leu  Ser Lys Ser Met Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Ser  Val Thr Gly Glu Lys  Leu Val Leu Ala Leu  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Val Asp Pro Phe Ala  Arg Gly Gly Lys Thr  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Val Gly Thr Trp Arg  Ser Gly Arg Ser Leu  Ser Ala Leu 
    2270                 2275                 2280             


Glu Asn  Ser Met Phe Ser His  Tyr Arg Arg His Ser  Lys Asp Ala 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Asp  Gln Thr Ser Asn Gly  Lys Ile Ser 
    2300                 2305                 2310             


Leu Arg  Asp Ala Leu Arg Ser  Ser Glu Ser Val Asp  Asp Ala Ala 
    2315                 2320                 2325             


Gly Val  Ile Cys Asn Gly Leu  Leu Gly Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Ala Val  Ser Val Glu Gln Phe  Ser Ser Glu Met Ser  Leu Thr Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Ser  Ile Pro Met Leu Glu  Leu Leu Gly 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Leu Glu Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Lys Leu  Leu Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  246
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  246

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Arg 
        35                  40                  45              


Leu Ile Cys Glu Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Arg His Gly Ser 
65                  70                  75                  80  


His Asn Val Glu Tyr Gly His Phe Phe His Asp Asp Leu Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Glu Lys Ile Met Gly Thr Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Phe Ala Thr Asp Tyr Thr Asp Leu Leu Thr Arg Asp Pro 
145                 150                 155                 160 


Asp Thr Val Pro Leu Tyr Gln Cys Thr Asn Ser Gly Gln Ser Arg Ala 
                165                 170                 175     


Met Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Val Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Val Ile Asn His Glu Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Ser Ser Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Val Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Arg Pro Glu Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Phe Val Asp Trp Arg 
                405                 410                 415     


Leu Lys Val Ala Thr Gln Leu Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Phe Leu Thr Ser Arg Gly Leu Ser Asn 
    450                 455                 460                 


Gly Gln Lys His Ser Thr His Phe Leu Arg Tyr Lys Phe Gly Ala Val 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Val Asn Glu Phe Ile His Glu Asn Gly Ala 
                485                 490                 495     


Ser Pro Ile Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Thr 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Ala Ile Tyr Asn His Ser Gly Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ala Phe Thr Leu Asn Glu Arg Arg Thr Lys Phe Ile 
545                 550                 555                 560 


Tyr Lys Ala Ala Val Val Ala Ala Ser Pro Lys Glu Leu Leu Glu Ala 
                565                 570                 575     


Leu Ser Lys Pro Ile Lys Phe Ser Arg Ser Ile Lys Ser Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Lys 
        595                 600                 605             


Glu Leu Leu Glu Val Tyr Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Tyr Leu His Ser Ile Gly Ala Pro Phe Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Lys Met Glu Pro Lys Leu Ser Lys Ile Asn Arg Ala Leu Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Val Ser Ser Thr Arg Met Gln Glu Glu 
705                 710                 715                 720 


His Lys Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Thr Lys Tyr Leu Ala Glu Leu Lys Ser Gly Arg Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Ile Leu Glu Ser Lys Gly Ile Phe Ala Arg 
    770                 775                 780                 


Met Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Ala Glu Asp Tyr Ala Lys Ala Ile Ala Gly Ile Arg Thr Arg Asn Gly 
                805                 810                 815     


Asn Gly Val Lys Phe Trp Ser Ser Val Tyr Gly Arg Glu Ile Gly Gly 
            820                 825                 830         


Asp Glu Leu Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Asp Ala Met Arg Gln Leu Cys Leu Ala Pro Gly Val Gln 
    850                 855                 860                 


Ser Lys Arg Arg Gln Ala Lys Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Lys Glu Ile Leu Gln 
                885                 890                 895     


Ser Asp Pro Lys Leu Arg Val Ala Asp Ile Met Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Lys Val Asp Ala Val Arg Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Ile Gly Tyr Gln Val Asn Tyr Ala Ala Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Ala Ser Val Leu Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Arg Arg Ser Lys Ala 
                965                 970                 975     


Phe Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Val Lys Asp 
            980                 985                 990         


Glu Asn Ser Asp Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Ile Pro Trp Leu Leu  Gln His Lys Ile Gln  Ser Ser Val 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Phe Ala Lys Lys Ile  Thr Gly Tyr 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Ala Thr Ala Leu Leu  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Ile Glu Thr Val  Leu Thr Leu Arg Pro  Met Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Ser Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Leu  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Val Gln His Gln Lys  Gln Gln Glu Ser Ser  Arg Glu Thr 
    1115                 1120                 1125             


His Val  Ser Ile Gln Pro Ala  Val Asp Glu Phe Arg  Thr Thr Met 
    1130                 1135                 1140             


Pro Met  Pro Asp Phe Tyr Glu  His Leu Ser Ser Leu  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Arg  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Tyr Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Val Phe Gly Gly Leu  Ser Ala Asp 
    1205                 1210                 1215             


Asn Phe  Leu Gln Asp Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Met Pro  Phe Gln Ala Gly His  Leu Val Lys 
    1235                 1240                 1245             


Ala Asn  Ala Ile Ile Ser Ala  Arg Asp Asn Gln Ser  Met Lys Thr 
    1250                 1255                 1260             


Asp Ile  Ile Val Ile Asp Asp  Ser Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Val Pro Arg Pro  Ile Glu Gln 
    1280                 1285                 1290             


Glu Asp  Ile Ala Asp Asn His  His Leu Ala Tyr Thr  Leu Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Glu Phe Leu  Asp Leu Lys Asn Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Tyr  Leu Arg Leu Leu Gly  Phe Lys Asn 
    1325                 1330                 1335             


Pro Glu  Ile Ser Val Leu Asp  Val Ser Ala Ser Ser  Ser Ser Ile 
    1340                 1345                 1350             


Met Ser  Phe Leu Lys Ala Leu  Glu Ile Ala Asn Ser  Ala Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Lys 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Val  Pro Asp Leu Pro Tyr  Asp Val Val 
    1385                 1390                 1395             


Thr Lys  Lys Ala Leu Asp Leu  Asp Ile Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Lys Ser 
    1430                 1435                 1440             


Leu Leu  Arg Pro Asp Gly Lys  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Asp  Gln Glu Pro Leu Phe  Leu Asn Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Lys Leu Val Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Asp  Arg Val Asp Gln Gly  Ser Leu Phe Val Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Thr Asn Pro Ala Thr  Pro Glu Ile Ile Val  Met Gly Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Ile Asp  Thr Ser His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Gly Leu  Glu Pro Gly Asn Ile  Glu Gln Ser Ser Ile  Tyr Glu Ile 
    1535                 1540                 1545             


Ala Pro  Thr Glu Lys Ile Leu  Ile Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Val Leu  Ser Ser Pro Ser Ile  Glu Gln Phe Glu Ala  Ile Lys Arg 
    1565                 1570                 1575             


Ile Phe  Thr Gln Thr Asn Lys  Leu Leu Trp Val Thr  Ser Gly Lys 
    1580                 1585                 1590             


Gly Gln  Gly Ser Arg Arg Pro  Glu Ser Asn Met Ile  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Thr Glu  Asn Gly Ala Ala Lys  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Asp  Lys Leu Ser Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Val Leu  Lys Arg Ser Phe Leu  Gly Asn Glu 
    1640                 1645                 1650             


Gln Gln  His Met Gly Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Ile 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Thr Leu  Asn Gln Ala 
    1670                 1675                 1680             


Leu Asp  Thr Tyr Leu Asn Pro  Thr Ala Lys Glu Ile  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Gly Ile Val Phe  Ser Leu Leu Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Ile Ala Phe Asp  Asp Glu Leu 
    1715                 1720                 1725             


Glu Asp  Asn Glu Ile Arg Ile  Glu Val Lys Ala Met  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Asn Ile  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Glu Gln  Val Ser Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Arg Val Ser Asn  Ser Tyr Arg 
    1775                 1780                 1785             


Gly Arg  Ala Thr Ala Phe Gln  Lys Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Leu Ala His  Val Thr Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Ile Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Glu  Glu Arg Ser Val Ala  Ala Leu Met 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Ile Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Ile  Glu Asn Ser 
    1925                 1930                 1935             


Arg Leu  Glu Met Ala Asn Phe  Arg Lys Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Glu Glu Arg Pro Ala  Leu Ala Asp 
    1955                 1960                 1965             


Glu Ile  Trp Gly Gln Thr Ile  Asp Leu Ile Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Thr Ser  Thr Val Pro Asn Leu  Gln Leu Phe Asn Gly  Glu Gly Ile 
    1985                 1990                 1995             


Thr Gln  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Ser Phe Asn Pro  Ser Asp Arg Val Met  Ile Ile Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Asp Gln Leu  Phe Arg Ala Asp Ala  Ser Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Lys  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Met  Ser Lys Gln Glu Ala  Arg Ala Thr Val His  Ala Leu Arg 
    2075                 2080                 2085             


Ser Leu  Gly Ala Arg Val His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Arg Gln Leu  Ile Glu Glu Cys Gly  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Glu 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Leu Thr  Leu Asp Asp Trp Gln  Ala Val Ile 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Trp Asn Leu His Gln  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Phe Phe Ile  Met Leu Ser Ser Val  Ser Gly Leu 
    2165                 2170                 2175             


Ile Gly  Asn Thr Thr Gln Ala  Ala Tyr Ala Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Asp  Ala Phe Ser Gly Phe  Arg Asn Ala Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Val Ser  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Phe Leu Ala 
    2210                 2215                 2220             


Thr Glu  Glu Asn Lys Gln Val  Thr Lys Ser Met Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Ser  Met Thr Gly Glu Lys  Leu Leu Leu Ala Leu  Ile Arg Ser 
    2240                 2245                 2250             


Gly Ile  Val Glu Pro Phe Gly  Arg Ala Ala Lys Thr  Gln Thr Ile 
    2255                 2260                 2265             


Thr Gly  Leu Gly Thr Trp Arg  Ser Gly Arg Ser Leu  Ser Ala Leu 
    2270                 2275                 2280             


Glu Asn  Ser Met Phe Ser His  Tyr Arg Arg His Ser  Lys Glu Gly 
    2285                 2290                 2295             


Glu Leu  Ile Ala Glu Lys Glu  Gln Ser Ser Asn Gly  Lys Met Ser 
    2300                 2305                 2310             


Val Arg  Glu Ala Leu Lys Ser  Ser Glu Ser Val Glu  Asp Ala Ala 
    2315                 2320                 2325             


Ala Ile  Ile Cys Asn Ala Leu  Leu Gly Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Gly Val  Ser Met Glu Gln Phe  Ser Ser Glu Met Ser  Leu Thr Asp 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Ser  Ile Pro Leu Leu Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Val Asp Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Lys Leu  Val Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  247
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  247

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Lys 
        35                  40                  45              


Leu Ile Cys Glu Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Arg His Gly Ser 
65                  70                  75                  80  


His Asn Val Glu Tyr Gly His Phe Phe His Asp Asp Met Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Glu Lys Leu Val Gly Thr Arg Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Phe Ala Thr Asp Tyr Ser Asp Leu Leu Thr Arg Asp Pro 
145                 150                 155                 160 


Glu Ser Val Pro Ile Tyr Gln Cys Thr Asn Ser Gly Gln Ser Arg Ala 
                165                 170                 175     


Met Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Val Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Met 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Val Leu Asn His Glu Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Leu Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Thr Ser Gly Ile Thr Val 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Gly Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Lys Pro Asp Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Phe Val Asp Trp Lys 
                405                 410                 415     


Leu Arg Val Ala Thr Asn Leu Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Gly Leu Ser Asn 
    450                 455                 460                 


Ala Gln Lys His Ser Thr His Phe Leu Arg Tyr Lys Tyr Gly Ala Val 
465                 470                 475                 480 


Asn Thr Ser Pro Lys Pro Val Asn Glu Phe Ile His Glu Asn Ala Ala 
                485                 490                 495     


Ser Pro Ile Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Ser Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Thr 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Gly Ile Tyr Asn His Ser Gly Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ala Phe Thr Leu Asn Glu Arg Arg Thr Arg Phe Ile 
545                 550                 555                 560 


Trp Lys Ala Ala Val Val Ala Gly Ser Pro Lys Asp Leu Ile Asp Ala 
                565                 570                 575     


Leu Ser Lys Pro Ile Lys Phe Ser Arg Ser Ile Lys Ser Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Lys 
        595                 600                 605             


Glu Leu Leu Glu Val Phe Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Tyr Leu His Ser Leu Gly Ala Pro Phe Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Arg Met Asp Pro Lys Val Ser Arg Ile Asn Lys Ala Val Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Ser Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Asp Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Val Ser Ser Thr Arg Leu Gln Glu Glu 
705                 710                 715                 720 


His Lys Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Thr Arg Phe Leu Ala Glu Leu Lys Ser Gly Lys Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Glu Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Ile Leu Glu Ser Lys Gly Ile Phe Ala Arg 
    770                 775                 780                 


Met Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Ala Glu Asp Tyr Ala Lys Ala Ile Ala Gly Ile Arg Thr Arg Gln Gly 
                805                 810                 815     


Asn Ala Ile Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Ile Gly Gly 
            820                 825                 830         


Asp Asp Leu Gly Pro Ser Tyr Trp Leu Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Asp Ala Met Arg Asn Leu Cys Leu Ala Pro Ala Ile Asn 
    850                 855                 860                 


Ser Lys Arg Arg Asn Ala Lys Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Arg Glu Ile Ile Gln 
                885                 890                 895     


Ser Asp Pro Lys Leu Arg Val Ala Asp Ile Ile Tyr Ala Ser Ala Leu 
            900                 905                 910         


Leu Arg Lys Met Asp Ala Val Arg Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Ile Gly Tyr Gln Val Asn Tyr Ala Ala Leu Gln Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Ala Ser Met Leu Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Arg Arg Ser Arg Ala 
                965                 970                 975     


Tyr Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Ile Arg Asp 
            980                 985                 990         


Glu Asn Ser Asp Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Ile Pro Trp Leu Val  Gln His Arg Ile Gln  Ser Ser Val 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Trp Ala Lys Lys Ile  Thr Ala Tyr 
    1040                 1045                 1050             


Gln Leu  Lys Glu Val Asn Ile  Gly Thr Ala Leu Val  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Val Glu Thr Ile  Leu Thr Leu Arg Pro  Ile Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Ser Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Leu  Ser Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Val Gln His Asn Lys  Gln Gln Glu Ser Ser  Arg Glu Thr 
    1115                 1120                 1125             


His Leu  Thr Ile Gln Pro Ala  Val Glu Asp Phe Arg  Thr Ser Val 
    1130                 1135                 1140             


Pro Ile  Pro Glu Phe Tyr Glu  His Leu Ser Ser Ile  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Met Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Ile Pro  Leu Asp Gln Glu His  Ser Tyr Ile Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Met Phe Gly Ala Leu  Ser Ala Asp 
    1205                 1210                 1215             


Asn Trp  Leu Gln Asp Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Tyr Ile  Ser Ala Asp Val Pro  Phe Gln Gly Gly His  Leu Val Lys 
    1235                 1240                 1245             


Ala Asn  Ala Ile Met Thr Ala  Arg Asp Asn Gln Thr  Leu Lys Thr 
    1250                 1255                 1260             


Asp Ile  Ile Val Leu Asp Asp  Ser Lys Asn Ala Pro  Leu Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Ile Pro Lys Pro  Ile Glu Gln 
    1280                 1285                 1290             


Glu Asp  Leu Ala Asp Gln His  His Leu Ala Tyr Thr  Leu Glu Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Glu Phe Leu  Glu Leu Lys Asn Thr  Asn Gln Ile 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Phe  Leu Arg Leu Leu Gly  Phe Arg Asn 
    1325                 1330                 1335             


Pro Glu  Leu Ser Val Leu Asp  Val Ser Ala Ser Thr  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Asp Ile Gly Asn Ser  Ala Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Lys 
    1370                 1375                 1380             


Ala Ala  Leu Ile Ser Asp Val  Pro Glu Leu Pro Tyr  Asp Leu Val 
    1385                 1390                 1395             


Ser Lys  Lys Ala Leu Asp Val  Glu Ile Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Lys Ser 
    1430                 1435                 1440             


Leu Leu  Lys Pro Asp Gly Lys  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Asp  Gln Asp Pro Val Phe  Leu Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Lys Met Val Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Glu  Arg Val Asp Gln Gly  Ser Val Phe Leu Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Thr Asn Pro Ala Thr  Pro Glu Val Val Val  Met Ala Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Ile Asp  Thr Thr His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Gly Leu  Glu Pro Gly Asn Ile  Glu Gln Ser Ser Val  Tyr Asp Leu 
    1535                 1540                 1545             


Ala Pro  Thr Glu Lys Ile Leu  Met Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Val Leu  Ser Ser Pro Ser Ile  Glu Gln Phe Asp Ala  Ile Lys Lys 
    1565                 1570                 1575             


Ile Phe  Thr Gln Ser Asn Arg  Val Leu Trp Val Thr  Thr Gly Arg 
    1580                 1585                 1590             


Gly Gln  Gly Ser Arg Arg Pro  Glu Ser Asn Met Ile  Thr Gly Leu 
    1595                 1600                 1605             


Gly Arg  Thr Ala Arg Thr Glu  Asn Gly Ala Ala Arg  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Glu Glu Asp  Lys Leu Ser Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Gly Val Leu  Lys Arg Ser Phe Leu  Gly Asn Glu 
    1640                 1645                 1650             


Gln Gln  His Met Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Leu 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Thr Leu  Asn Gln Ala 
    1670                 1675                 1680             


Ile Asp  Ser Tyr Ile Asn Pro  Thr Ala Lys Glu Leu  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Gly Ile Val Phe  Ser Leu Val Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Ile Ala Tyr Asp  Asp Asp Leu 
    1715                 1720                 1725             


Glu Glu  Asn Glu Ile Arg Ile  Glu Val Arg Ala Val  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Asn Ile  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Asp Gln  Val Ser Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Arg Val Ser Asn  Ser Tyr Lys 
    1775                 1780                 1785             


Gly Arg  Gly Ser Ala Phe Gln  Arg Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Leu Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Ile Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Glu 
    1865                 1870                 1875             


Gln Ile  Leu Tyr Asn Asn Asp  Glu Arg Ser Val Ala  Ala Leu Leu 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Leu Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Ile Ile  Glu Asn Thr 
    1925                 1930                 1935             


Arg Leu  Glu Met Ala Asn Phe  Arg Arg Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Asp Glu Arg Pro Ala  Leu Ala Asp 
    1955                 1960                 1965             


Glu Leu  Trp Ala Gln Thr Ile  Glu Leu Leu Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Val  Gln Leu Phe Asn Gly  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Phe Asn Pro  Ser Asp Arg Ile Met  Val Leu Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Asp Gln Leu  Phe Lys Ala Asp Ala  Thr Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Lys  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Ala Met  Ser Lys Gln Glu Ala  Arg Ala Thr Val His  Ala Leu Lys 
    2075                 2080                 2085             


Ser Met  Gly Ala Lys Val His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Arg Gln Leu  Val Glu Glu Cys Gly  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Ile Thr  Val Asp Asp Trp Asn  Ala Val Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Tyr Asn Leu His Asn  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Phe Phe Ile  Leu Leu Ser Ser Ile  Ser Gly Ile 
    2165                 2170                 2175             


Ile Gly  Asn Thr Thr Gln Ala  Ala Tyr Gly Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Asp  Ala Phe Ser Gly Phe  Arg Asn Ala Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Val Ser  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Tyr Leu Ala 
    2210                 2215                 2220             


Thr Glu  Glu Asn Lys Gln Ile  Thr Lys Ser Met Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Ser  Met Thr Gly Glu Lys  Leu Val Ile Ala Leu  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Arg Gly Gly Lys Thr  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Leu Gly Ser Trp Arg  Ser Ala Arg Ser Leu  Ser Ala Val 
    2270                 2275                 2280             


Glu Asn  Ser Met Phe Ser His  Tyr Arg Arg His Ser  Lys Glu Ala 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Asp  Gln Thr Ser Asn Gly  Lys Ile Ser 
    2300                 2305                 2310             


Val Lys  Asp Ala Leu Arg Ser  Ser Glu Ser Val Asp  Asp Gly Ala 
    2315                 2320                 2325             


Gly Ile  Ile Cys Asn Ala Leu  Leu Gly Tyr Leu Ala  Thr Arg Ser 
    2330                 2335                 2340             


Gly Leu  Ser Val Asp Asn Phe  Ser Ser Glu Val Ser  Leu Ser Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Lys  Asp Leu Glu Ser Ser  Ile Pro Leu Leu Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Ile Asp Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Lys Leu  Val Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  248
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  248

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Ala Arg Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Lys 
        35                  40                  45              


Met Ile Cys Asp Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Arg His Gly Thr 
65                  70                  75                  80  


His Asn Val Asp Trp Gly His Phe Phe His Glu Asp Ile Thr Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Glu Lys Ile Val Gly Thr Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Trp Ala Thr Asp Tyr Thr Asp Met Val Thr Arg Asp Pro 
145                 150                 155                 160 


Glu Ser Leu Pro Met Phe Gln Cys Thr Asn Ser Gly Gln Ser Arg Ala 
                165                 170                 175     


Val Ile Ser Asn Arg Leu Ser Tyr Tyr Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Leu Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Ile Ile Asn His Glu Phe Ile Thr Thr Met Ser Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Thr Ser Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Leu Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Arg Pro Glu Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Phe Val Asp Trp Lys 
                405                 410                 415     


Leu Arg Val Ala Thr Asn Val Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Ile Thr Ser Arg Ala Leu Ser Asn 
    450                 455                 460                 


Ala Gln Lys His Thr Thr His Phe Leu Arg Tyr Lys Tyr Gly Ala Ile 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Val Asn Glu Phe Ile His Glu Asn Gly Ala 
                485                 490                 495     


Ser Pro Ile Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Thr 
        515                 520                 525             


Leu Leu Lys His Leu His Glu Arg Gly Ile Tyr Asn His Ser Ala Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ala Phe Thr Leu Asn Glu Arg Arg Thr Lys Phe Ile 
545                 550                 555                 560 


Trp Lys Ala Ala Val Val Ala Ala Ser Pro Lys Glu Leu Ile Asp Ala 
                565                 570                 575     


Leu Ser Lys Pro Leu Lys Phe Ser Arg Thr Ile Lys Ser Gly Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Lys 
        595                 600                 605             


Asp Leu Leu Glu Val Tyr Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Tyr Leu His Ser Ile Gly Ala Pro Trp Asp Val Glu Asp Glu 
625                 630                 635                 640 


Ile Lys Met Glu Pro Lys Val Thr Lys Ile Asn Lys Ala Val Phe Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Ser Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Asp Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Ile Ser Ser Thr Arg Leu Gln Glu Asp 
705                 710                 715                 720 


His Lys Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Thr Arg Phe Leu Ala Glu Leu Lys Ser Gly Lys Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Met Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Ile Leu Glu Ser Lys Gly Val Phe Ala Arg 
    770                 775                 780                 


Val Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Ala Asp Asp Tyr Ala Lys Ala Ile Ala Gly Ile Arg Thr Arg Gln Gly 
                805                 810                 815     


Asn Gly Met Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Ile Gly Ala 
            820                 825                 830         


Asp Asp Val Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Asp Ala Met Arg Gln Leu Cys Leu Ala Pro Ala Leu Gln 
    850                 855                 860                 


Ser Lys Lys Arg Gln Ala Lys Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Lys Glu Ile Leu Gln 
                885                 890                 895     


Ser Asp Pro Arg Met Lys Val Ala Asp Ile Val Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Lys Val Asp Gly Val Arg Ser Val Leu Asp Leu Ala Gly Arg 
        915                 920                 925             


Leu Ser Ala Leu Gly Tyr Gln Val Asn Tyr Ala Ala Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Ala Ser Val Leu Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Arg Arg Ser Lys Gly 
                965                 970                 975     


Phe Arg Asn Lys Ile Phe Pro Arg Val Asp Ile Leu Gly Val Arg Asp 
            980                 985                 990         


Glu Asn Ser Asp Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Ile Pro Trp Leu Leu  Gln His Lys Ile Gln  Ser Thr Val 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Phe Ala Lys Lys Ile  Thr Gly Tyr 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Thr Ala Leu Leu  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Leu Glu Thr Ile  Leu Thr Leu Arg Pro  Ile Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Thr Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Val  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Leu Gln His Gln Lys  Asn Gln Glu Ser Ser  Arg Glu Ser 
    1115                 1120                 1125             


His Leu  Thr Ile Gln Pro Gly  Val Glu Asp Phe Arg  Thr Thr Val 
    1130                 1135                 1140             


Pro Met  Pro Glu Phe Tyr Glu  His Leu Ser Ser Leu  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Phe Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Val Phe Gly Ala Leu  Ser Ala Asp 
    1205                 1210                 1215             


Asn Trp  Val Gln Glu Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Leu Pro  Phe Gln Ala Gly His  Leu Leu Lys 
    1235                 1240                 1245             


Gly Asn  Ala Val Ile Ser Ala  Arg Asp Asn Gln Thr  Leu Lys Ser 
    1250                 1255                 1260             


Asp Ile  Leu Val Ile Asp Asp  Ser Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Leu Pro Arg Pro  Ile Glu Gln 
    1280                 1285                 1290             


Glu Asp  Ile Ala Asp Asn His  His Met Ala Phe Thr  Val Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Leu Glu Trp Met  Asp Leu Lys Gln Thr  Gln Gln Leu 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Tyr  Leu Arg Leu Leu Gly  Phe Arg Gln 
    1325                 1330                 1335             


Pro Glu  Leu Ser Val Leu Asp  Val Ser Ala Ser Ser  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Glu Ile Gly Asn Ser  Ala Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Lys 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Val  Pro Asp Leu Pro Tyr  Asp Leu Val 
    1385                 1390                 1395             


Thr Lys  Lys Ala Leu Asp Leu  Glu Ile Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Thr Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Lys Ser 
    1430                 1435                 1440             


Leu Leu  Arg Pro Asp Gly Arg  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Asp  Gln Glu Pro Val Phe  Leu Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Lys Leu Ile Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Glu  Arg Val Asp Gln Gly  Thr Val Phe Met Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Ser Asn Pro Ala Thr  Pro Glu Ile Ile Val  Met Ala Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Ile Asp  Thr Ser His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Ala Leu  Glu Pro Gly Asn Ile  Glu Gln Thr Ser Ile  Tyr Asp Val 
    1535                 1540                 1545             


Ala Pro  Thr Asp Lys Ile Leu  Val Val Tyr Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Ile Leu  Ser Ser Pro Ser Ile  Glu Gln Phe Glu Ala  Ile Lys Arg 
    1565                 1570                 1575             


Ile Phe  Thr Gln Ser Asn Lys  Val Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Gly Gln  Gly Ser Arg Arg Pro  Glu Ser Asn Met Ile  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Ser Glu  Asn Gly Ala Ala Arg  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Asp  Lys Leu Ser Arg Asn  Glu Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Ile Leu  Lys Arg Ser Trp Leu  Gly Asn Glu 
    1640                 1645                 1650             


Asn Gln  His Met Ala Glu Ser  Glu Tyr Leu Asp Arg  Lys Gly Ile 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Thr  Val Asp Asp Thr Leu  Asn Gln Gly 
    1670                 1675                 1680             


Leu Asp  Ser Tyr Leu Asn Pro  Thr Ala Lys Glu Val  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Gly Ile Val Phe  Ser Leu Leu Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Asp Val Ala Phe Asp  Asp Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Asp Ile Arg Ile  Glu Val Lys Ala Met  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Asn Ile  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Asp Gln  Val Ser Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Lys Val Ser Asn  Ser Tyr Arg 
    1775                 1780                 1785             


Gly Lys  Ala Ser Ala Phe Gln  Lys Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Ile Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Leu Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Glu  Asp Arg Ser Leu Ala  Ala Leu Ile 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Leu Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Trp 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Ile Ile  Glu Asn Ser 
    1925                 1930                 1935             


Arg Leu  Asp Met Gly Gln Phe  Arg Lys Asn Thr Ser  Phe Ser Gly 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Glu Glu Lys Pro Ala  Leu Ala Asp 
    1955                 1960                 1965             


Glu Ile  Trp Gly Gln Thr Met  Asp Leu Ile Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Leu  Gln Leu Phe Gln Gly  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Ser Trp Asn Pro  Ser Asp Arg Val Met  Ile Leu Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Asp Gln Leu  Phe Arg Ala Glu Ala  Ser Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Lys  Asn Leu Ile Phe Gly  Asn Arg Ser 
    2060                 2065                 2070             


Gly Met  Ser Lys Asn Glu Ala  Arg Ala Thr Val His  Ala Leu Lys 
    2075                 2080                 2085             


Ser Met  Gly Ala Arg Val His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Lys Gln Ile  Val Glu Glu Cys Gly  Ser Gln Leu 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Leu Thr  Ile Asp Asp Trp Asn  Ala Val Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Ser  Tyr Asn Leu His Asn  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Phe Phe Ile  Leu Leu Ser Ser Ile  Ser Gly Leu 
    2165                 2170                 2175             


Val Gly  Asn Thr Thr Gln Ala  Ala Tyr Ala Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Glu  Ala Phe Ser Gly Tyr  Arg Asn Gly Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Val Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Tyr Leu Ala 
    2210                 2215                 2220             


Ser Glu  Glu Asn Lys Gln Leu  Ser Lys Ser Ile Gln  Asp Gln Gly 
    2225                 2230                 2235             


Tyr Ser  Met Thr Gly Glu Lys  Leu Val Leu Ala Leu  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Arg Gly Ala Lys Ser  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Leu Gly Thr Trp Arg  Ser Gly Arg Ser Leu  Ser Gly Leu 
    2270                 2275                 2280             


Glu Asn  Ser Met Phe Ser His  Tyr Arg Arg His Ser  Lys Glu Ala 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Glu  Asn Thr Ser Asn Ala  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Asp Ala Leu Arg Ser  Ser Glu Ser Met Glu  Asp Ala Ala 
    2315                 2320                 2325             


Gly Val  Ile Cys Asn Ala Leu  Leu Gly Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Gly Val  Ser Leu Glu Asn Phe  Ser Ser Asp Leu Ser  Leu Thr Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Ser  Ile Pro Val Leu Asp  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Val Asp Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Arg Leu  Ile Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  249
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  249

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Thr Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Glu Gly Ser Ile Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Lys 
        35                  40                  45              


Val Ile Cys Glu Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Gly Phe Tyr His Pro Asn Tyr Gln Lys His Gly Ser 
65                  70                  75                  80  


His Asn Ile Glu Tyr Gly His Phe Phe His Asp Asp Ile Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Glu Arg Ile Val Gly Thr Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Thr Phe Gly Ser Asp Tyr Thr Asp Leu Leu Thr Arg Glu Pro 
145                 150                 155                 160 


Asp Ser Val Pro Val Tyr Gln Cys Thr Gln Ser Gly Gln Ser Arg Ala 
                165                 170                 175     


Met Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Val Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Leu Leu Asn His Glu Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Arg Thr Ser Gly Ile Thr Met 
    290                 295                 300                 


Pro Asn Pro Leu Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Ala Ala Asn Arg Pro Glu Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Trp Val Asp Trp Lys 
                405                 410                 415     


Leu Arg Val Ala Thr Asn Met Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Gly Leu Ser Asn 
    450                 455                 460                 


Ala Gln Lys His Ser Thr His Phe Leu Arg Tyr Lys Tyr Gly Ala Met 
465                 470                 475                 480 


Asn Thr Ser Pro Lys Pro Val Asn Glu Tyr Val His Glu Asn Gly Ala 
                485                 490                 495     


Ser Pro Ile Asp Ser Pro Val Pro Asn Tyr Thr His Pro Arg Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Ser 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Gly Ile Tyr Asn His Ser Ala Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ala Tyr Thr Leu Asn Glu Arg Arg Thr Arg Phe Ile 
545                 550                 555                 560 


Tyr Lys Ala Ala Val Val Ala Gly Ser Pro Lys Glu Leu Ile Asp Ala 
                565                 570                 575     


Leu Ser Lys Pro Ile Lys Phe Ser Arg Ser Met Lys Thr Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Arg 
        595                 600                 605             


Asp Leu Val Glu Val Tyr Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Tyr Leu His Ser Leu Gly Ala Pro Phe Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Arg Met Asp Pro Lys Val Ser Arg Ile Asn Arg Ala Leu Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Val Ser Ser Thr Lys Met Gln Glu Glu 
705                 710                 715                 720 


His Lys Gly Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Glu 
                725                 730                 735     


Ala Thr Arg Phe Leu Ala Asp Leu Lys Ser Gly Arg Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Leu Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Leu Leu Glu Ser Lys Gly Val Phe Ala Arg 
    770                 775                 780                 


Ile Leu Ala Val Glu Ile Ala Tyr His Ser His His Met Asp Leu Val 
785                 790                 795                 800 


Ala Asp Glu Tyr Ala Lys Ala Ile Ala Gly Leu Arg Thr Arg Gln Gly 
                805                 810                 815     


Asn Gly Val Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Ile Gly Ala 
            820                 825                 830         


Asp Asp Val Gly Pro Ser Tyr Trp Leu Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Ser Asp Ala Met Lys Gln Leu Cys Leu Ala Pro Ala Ile Gln 
    850                 855                 860                 


Ser Lys Arg Arg Gln Ala Lys Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Arg Glu Ile Ile Asn 
                885                 890                 895     


Thr Asp Pro Lys Leu Lys Val Ala Asp Leu Val Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Lys Val Asp Ala Val Lys Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Leu Gly Tyr Gln Val Asn Tyr Ala Gly Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Gly Ser Val Ile Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Arg Arg Thr Arg Ala 
                965                 970                 975     


Phe Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Val Arg Glu 
            980                 985                 990         


Asp Gln Ser Asp Pro Leu Gln Val  Ser Trp Arg Asn His  Leu Lys Thr 
        995                 1000                 1005             


Ser Asp  Ile Pro Trp Leu Leu  Gln His Lys Ile Gln  Ser Ser Ile 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Lys Ser Lys Glu Arg  Phe Gly Lys Lys Val  Ser Gly Tyr 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Thr Ala Leu Val  Leu Pro Asp 
    1055                 1060                 1065             


Gln Asp  Thr Leu Glu Thr Ile  Leu Ser Leu Lys Pro  Ile Arg Glu 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Ser Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Val  Thr Asn Glu Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Leu Gln His Gln Lys  Gln Gln Glu Ser Ser  Arg Glu Thr 
    1115                 1120                 1125             


His Ile  Ser Leu Gln Pro Ala  Val Glu Glu Phe Arg  Ser Thr Leu 
    1130                 1135                 1140             


Pro Met  Pro Glu Trp Tyr Glu  His Leu Ser Ser Leu  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Leu Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Phe Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Val Phe Gly Ala Met  Ser Gly Asp 
    1205                 1210                 1215             


Asn Trp  Leu Asn Asp Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Ile Pro  Phe Gln Gly Gly His  Leu Leu Arg 
    1235                 1240                 1245             


Ala Asn  Ala Ile Val Ser Ala  Arg Asp Asn Gln Thr  Val Lys Thr 
    1250                 1255                 1260             


Asp Val  Ile Val Ile Asp Asp  Ser Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Leu Pro Arg Pro  Met Glu Asn 
    1280                 1285                 1290             


Asp Asp  Met Ala Asp Asn His  His Met Ala Tyr Thr  Leu Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Glu Phe Leu  Asp Val Lys Gln Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Tyr  Leu Arg Ile Leu Gly  Phe Arg Asn 
    1325                 1330                 1335             


Pro Glu  Ile Thr Val Leu Asp  Val Ser Ala Ser Ser  Ser Ser Ile 
    1340                 1345                 1350             


Val Ser  Phe Leu Lys Ala Leu  Glu Ile Gly Asn Thr  Ala Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Arg 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Val  Pro Asp Val Pro Tyr  Asp Ile Ile 
    1385                 1390                 1395             


Ser Lys  Lys Ala Leu Asp Leu  Glu Ile Ala Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Arg Ser 
    1430                 1435                 1440             


Leu Leu  Arg Pro Asp Gly Arg  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Val Asp  Gln Asp Pro Val Phe  Leu Gln Trp Lys Thr  Thr Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Arg Leu Ile Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Glu  Arg Val Glu Gln Gly  Thr Val Phe Leu Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Asp  Ser Asn Pro Gly Ser  Pro Glu Ile Ile Val  Met Gly Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Ile Glu  Thr Ser His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Ala Leu  Glu Pro Gly Asn Ile  Glu Gln Ser Thr Val  Tyr Asp Ile 
    1535                 1540                 1545             


Ala Pro  Ser Asp Lys Ile Leu  Val Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Leu Leu  Ser Ser Pro Ser Ile  Asp Gln Phe Glu Ala  Ile Lys Arg 
    1565                 1570                 1575             


Ile Phe  Ser Gln Ser Asn Arg  Ile Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Gly Gln  Gly Ser Lys Arg Pro  Glu Ser Asn Ile Ile  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Thr Glu  Asn Gly Gly Ala Lys  Val Val Ser 
    1610                 1615                 1620             


Leu Asp  Leu Asp Glu Glu Asp  Arg Leu Ser Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Ile Leu  Lys Arg Ser Phe Leu  Gly Asn Asp 
    1640                 1645                 1650             


Gln Gln  His Leu Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Ile 
    1655                 1660                 1665             


Leu Thr  Ile Pro Arg Leu Thr  Val Asp Asp Ser Leu  Asn Gln Ala 
    1670                 1675                 1680             


Ile Asp  Thr Tyr Leu Asn Pro  Ser Ala Lys Glu Val  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Ala Ile Val Phe  Ser Leu Leu Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Thr Phe Gln  Glu Leu Ala Phe Asp  Asp Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Glu Ile Arg Ile  Glu Val Lys Ala Val  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Asn Val  Ile Thr Gln Asp Val  Ser Gly Val 
    1745                 1750                 1755             


Val Leu  Lys Val Gly Asp Gln  Val Thr Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Arg Val Ser Asn  Thr Tyr Lys 
    1775                 1780                 1785             


Gly Arg  Ala Ser Ala Phe Gln  Lys Ile Pro Asp Gly  Met Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Leu Ala His  Val Ser Arg Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Met Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Glu  Glu Arg Ser Ile Ala  Ala Leu Ile 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Leu Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Phe 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Leu  Asp Asn Ser 
    1925                 1930                 1935             


Arg Leu  Asp Val Ala Asn Phe  Arg Arg Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Glu Glu Arg Pro Ala  Leu Ala Asp 
    1955                 1960                 1965             


Glu Val  Trp Gly Gln Thr Val  Asp Leu Ile Ser Arg  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Leu Pro Asn Leu  Gln Val Phe Asn Ala  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Lys Leu  Met Asp Glu Asp Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Trp Asn Pro  Ser Glu Lys Leu Met  Val Leu Pro 
    2015                 2020                 2025             


Thr Thr  Ser Arg Asp Gln Leu  Phe Arg Ala Asp Ala  Thr Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Lys  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Met  Ser Lys Gln Glu Ala  Arg Ala Thr Val His  Ala Leu Lys 
    2075                 2080                 2085             


Ser Met  Gly Gly Arg Val His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Asp  His Val Arg Gln Val  Val Asp Glu Cys Gly  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Asp Lys Ile Thr  Leu Asp Asp Phe Gln  Ala Ile Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Trp Asn Leu His Asn  His Val Pro 
    2150                 2155                 2160             


Lys Glu  Met Asp Phe Phe Ile  Leu Leu Ser Ser Ile  Ser Gly Ile 
    2165                 2170                 2175             


Met Gly  Asn Thr Thr Gln Ala  Ala Tyr Ala Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Glu  Gly Phe Ser Gly Tyr  Arg Asn Ala Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Val Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Tyr Leu Ala 
    2210                 2215                 2220             


Thr Asp  Glu Asn Lys Gln Val  Ser Lys Ser Leu Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Ser  Ile Thr Gly Glu Lys  Leu Ile Leu Ala Val  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Arg Gly Ala Lys Thr  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Leu Gly Ser Trp Arg  Ser Gly Arg Ser Leu  Ser Ala Leu 
    2270                 2275                 2280             


Glu Asn  Ser Leu Phe Ser His  Phe Arg Arg His Ser  Lys Glu Ala 
    2285                 2290                 2295             


Glu Val  Val Ala Glu Lys Glu  Gln Ser Ser Asn Gly  Lys Val Ser 
    2300                 2305                 2310             


Val Lys  Glu Ala Leu Lys Ser  Ser Glu Ser Ile Asp  Asp Ala Ala 
    2315                 2320                 2325             


Gly Val  Ile Cys Asn Gly Leu  Leu Ala Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Gly Val  Ser Val Asp Asn Phe  Ser Ser Glu Met Ser  Leu Thr Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Ser  Ile Pro Met Met Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Val Asp Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Lys Ile  Val Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  250
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  250

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Lys 
        35                  40                  45              


Met Ile Cys Glu Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Lys His Gly Ser 
65                  70                  75                  80  


His Asn Val Glu Tyr Gly His Phe Phe His Glu Asp Val Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Glu Arg Leu Val Gly Thr Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Thr Phe Ala Thr Asp Tyr Thr Asp Val Ile Ser Arg Glu Pro 
145                 150                 155                 160 


Glu Ser Ile Pro Met Tyr Gln Cys Thr Asn Ser Gly Asn Ser Arg Ala 
                165                 170                 175     


Ile Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Ile Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Val Leu Asn His Asp Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Leu Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Asp Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Arg Ser Ser Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Arg Pro Glu Asp Arg Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Glu Lys Pro Asn Pro Arg Ile Pro Trp Val Glu Trp Lys 
                405                 410                 415     


Leu Arg Val Ala Thr Asn Val Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Gly Ile Ser Asn 
    450                 455                 460                 


Ala Gln Lys His Thr Thr His Phe Ile Arg Tyr Lys Trp Ala Gly Val 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Val Asn Glu Phe Ile His Glu Asn Ala Ala 
                485                 490                 495     


Ser Pro Val Glu Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Ser Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Thr 
        515                 520                 525             


Leu Leu Lys His Leu His Glu Arg Gly Val Tyr Asn His Thr Gly Tyr 
    530                 535                 540                 


Leu Asp Asp Leu Ala Tyr Thr Leu Asn Glu Arg Arg Thr Lys Phe Ile 
545                 550                 555                 560 


Trp Lys Ala Ala Val Val Ala Ala Ser Pro Lys Asp Leu Ile Glu Ala 
                565                 570                 575     


Leu Ser Lys Pro Leu Lys Phe Thr Lys Ser Ile Arg Ser Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Lys 
        595                 600                 605             


Glu Leu Leu Glu Val Phe Pro Ile Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Tyr Leu His Ser Ile Gly Ala Pro Trp Asp Val Glu Asp Glu 
625                 630                 635                 640 


Ile Lys Met Glu Pro Lys Val Ser Lys Ile Asn Lys Ala Leu Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Asp Asp Ala Met 
    690                 695                 700                 


Ser Ala Ala Tyr Trp Arg Gly Val Ser Ser Thr Lys Met Gln Glu Asp 
705                 710                 715                 720 


His Lys Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Thr Arg Phe Leu Ala Glu Leu Lys Ser Gly Arg Ala Ile Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Ile Leu Glu Ser Lys Gly Val Phe Ala Arg 
    770                 775                 780                 


Ile Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Ala Glu Asp Tyr Ala Arg Ala Ile Ala Ala Ile Lys Thr Lys Gln Ala 
                805                 810                 815     


Asn Gly Val Lys Phe Tyr Ser Ser Val Tyr Gly Lys Glu Val Gly Ala 
            820                 825                 830         


Glu Asp Ile Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Asp Ala Met Arg Gln Leu Cys Leu Gly Pro Ala Ile Gln 
    850                 855                 860                 


Thr Lys Arg Arg Gln Ala Lys Arg His Asn Ile Glu Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Ala Pro Ile Arg Glu Ile Val Gln 
                885                 890                 895     


Ser Asp Pro Lys Leu Arg Ile Ala Asp Ile Val Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Lys Val Asp Ala Val Arg Thr Val Leu Glu Leu Ala Gly Arg 
        915                 920                 925             


Leu Ser Ala Leu Gly Tyr Gln Val Asn Tyr Ala Ala Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Ala Ser Met Leu Val Asp Leu Pro Thr Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Ser Ser Tyr Trp Ala Glu Pro Arg Arg Thr Arg Ala 
                965                 970                 975     


Phe Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Val Arg Asp 
            980                 985                 990         


Glu Asn Ser Glu Pro Leu Gln Ile  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Val Pro Trp Leu Leu  Gln His Arg Ile Gln  Ser Ser Val 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Phe Ala Lys Lys Met  Ser Ala Tyr 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Thr Ala Leu Leu  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Leu Glu Thr Met  Leu Thr Leu Lys Pro  Val Arg Glu 
    1070                 1075                 1080             


Ser Thr  Lys Lys His Ser Asp  Ser Trp Ser Glu Phe  His Ile Trp 
    1085                 1090                 1095             


Ser Val  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Val Gln His Gln Lys  Gln Gln Glu Ser Thr  Arg Asp Thr 
    1115                 1120                 1125             


His Val  Thr Val Gln Pro Ala  Leu Glu Glu Tyr Arg  Thr Thr Leu 
    1130                 1135                 1140             


Pro Val  Pro Glu Phe Tyr Glu  His Leu Ser Ser Ile  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Ser Gly Ile Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Tyr Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Val Leu His Thr  Val Phe Ala Ala Leu  Ser Ala Asp 
    1205                 1210                 1215             


Asn Trp  Leu Gln Glu Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Met Pro  Phe Asn Ala Gly His  Leu Leu Lys 
    1235                 1240                 1245             


Ala Asn  Ala Ile Val Ser Ala  Arg Asp Asn Asn Thr  Val Lys Thr 
    1250                 1255                 1260             


Asp Ile  Ile Val Ile Asp Glu  Ser Lys Asn Ala Pro  Leu Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Glu Trp Arg  Phe Val Pro Lys Pro  Ile Glu Gln 
    1280                 1285                 1290             


Asp Asp  Ile Ala Asp Asn His  His Val Ala Phe Thr  Leu Glu Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Asp Phe Leu  Glu Leu Lys Asn Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Tyr  Leu Arg Ile Leu Gly  Phe Lys Asn 
    1325                 1330                 1335             


Pro Glu  Ile Ser Val Leu Asp  Val Ser Ala Ser Thr  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Glu Ile Gly Asn Ser  Ala Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Lys 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Leu  Pro Asp Val Pro Tyr  Asp Leu Met 
    1385                 1390                 1395             


Ser Lys  Lys Ala Leu Asp Leu  Glu Ile Gly Pro Gln  Ser Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Arg Ser 
    1430                 1435                 1440             


Leu Leu  Arg Pro Asp Gly Arg  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Glu  Gln Asp Pro Leu Phe  Val Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Lys Val Ile Glu Ser  Glu Asp Ser 
    1475                 1480                 1485             


Gly Asp  Arg Val Asp Gln Gly  Ser Leu Phe Val Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Ser Asn Pro Ala Ser  Pro Glu Leu Ile Val  Met Ala Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Val Asp  Thr Ser His Leu Ala  Ser Leu Leu 
    1520                 1525                 1530             


Ala Leu  Glu Pro Gly Asn Ile  Asp Gln Ser Ser Val  Tyr Asp Val 
    1535                 1540                 1545             


Ala Pro  Thr Asp Lys Ile Leu  Ile Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Leu Leu  Ser Ser Pro Ser Ile  Asp Gln Phe Asp Ala  Ile Lys Arg 
    1565                 1570                 1575             


Val Phe  Thr Asn Ser Asn Arg  Leu Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Gly Gln  Gly Ser Arg Arg Pro  Glu Ser Asn Met Ile  Ser Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Thr Glu  Asn Gly Ala Gly Arg  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Asp  Arg Leu Ser Arg Asn  Asp Ala Ser 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Val Leu  Lys Arg Ser Trp Leu  Gly Asn Asp 
    1640                 1645                 1650             


Asn Gln  His Met Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Ile 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Thr Leu  Asn Gln Ala 
    1670                 1675                 1680             


Leu Asp  Thr Tyr Leu Asn Pro  Ser Ala Lys Glu Val  Gln Leu Val 
    1685                 1690                 1695             


His His  Lys Ala Ile Val Phe  Ser Leu Val Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Thr Phe Gln  Glu Ile Ala Phe Asp  Asp Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Glu Ile Arg Ile  Glu Val Lys Ala Val  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Gln Arg Val Asn Val  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Asp Gln  Val Thr Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Leu Thr  Asn Arg Val Ser Asn  Ser Tyr Arg 
    1775                 1780                 1785             


Gly Arg  Ala Thr Ala Phe Gln  Lys Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Val  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Phe Arg Leu Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Lys Leu Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Gly Leu His Phe  Pro Arg Asp 
    1865                 1870                 1875             


Gln Ile  Leu Tyr Asn Asn Asp  Asp Arg Ser Val Ala  Ala Leu Leu 
    1880                 1885                 1890             


Ala Asn  Thr Asn Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Ile Leu Gln Thr  Cys Trp Gln Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Val Ile  Glu Asn Thr 
    1925                 1930                 1935             


Lys Leu  Asp Met Gly Asn Phe  Arg Lys Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Glu Glu Arg Pro Ala  Val Ala Asp 
    1955                 1960                 1965             


Glu Ile  Trp Gly Gln Thr Met  Asp Leu Leu Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Ile  Gln Leu Phe Asn Gly  Asp Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Tyr Gln Pro  Ser Asp Arg Val Met  Val Leu Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Glu Gln Leu  Phe Arg Ala Asp Ala  Ser Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Arg  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Ile  Ser Lys Gln Glu Ala  Lys Ala Thr Val His  Ala Met Lys 
    2075                 2080                 2085             


Ser Leu  Gly Ala Arg Val His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Asp  His Val Lys Gln Leu  Val Glu Asp Cys Gly  Ser Gln Leu 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Leu Thr  Val Asp Asp Phe Asn  Ala Val Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Phe Asn Leu His Asn  His Leu Pro 
    2150                 2155                 2160             


Arg Asp  Met Asp Tyr Phe Ile  Leu Leu Ser Ser Ile  Ser Gly Val 
    2165                 2170                 2175             


Ile Gly  Gln Thr Thr Gln Ala  Ala Tyr Gly Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Asp  Gly Phe Ser Gly Phe  Arg Asn Ala Gln Gly  Leu Pro Gly 
    2195                 2200                 2205             


Val Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Met Gly  Tyr Ile Ala 
    2210                 2215                 2220             


Ser Asp  Glu Gln Lys Asn Val  Ser Lys Ser Leu Gln  Glu Gln Gly 
    2225                 2230                 2235             


Phe Ser  Met Thr Gly Glu Lys  Leu Ile Met Ala Val  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Arg Gly Gly Arg Thr  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Leu Gly Thr Trp Arg  Thr Gly Arg Ser Leu  Ser Ala Leu 
    2270                 2275                 2280             


Glu Asn  Ser Leu Phe Ser His  Tyr Arg Arg His Ser  Lys Glu Gly 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Glu  Gln Ser Ser Asn Gly  Lys Ile Ser 
    2300                 2305                 2310             


Val Arg  Asp Ala Leu Arg Ser  Ser Glu Ser Met Asp  Asp Ala Ala 
    2315                 2320                 2325             


Gly Val  Ile Cys Asn Ala Leu  Leu Ala Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Gly Val  Ser Val Glu Asn Phe  Ser Ser Asp Leu Ser  Leu Thr Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Thr  Ile Pro Leu Leu Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Thr Gln Leu  Ser Val Asp Ile Ala  Ser Lys Ser 
    2390                 2395                 2400             


Arg Leu  Leu Pro Val Glu Ile  Lys Ser Lys Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  251
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  251

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Val Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Glu Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Asp Asn Leu Phe Lys 
        35                  40                  45              


Met Ile Cys Glu Lys Arg Glu Ser Arg Ser Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Arg His Gly Ser 
65                  70                  75                  80  


His Asn Leu Asp Trp Gly His Phe Phe His Asp Asp Val Thr Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Thr Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Val Pro Leu Glu Lys Leu Val Gly Thr Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Phe Ala Ser Asp Tyr Thr Asp Leu Leu Thr Arg Asp Pro 
145                 150                 155                 160 


Glu Ser Ile Pro Met Phe Gln Cys Thr Asn Ser Gly Asn Ser Arg Ala 
                165                 170                 175     


Met Ile Ser Asn Arg Leu Ser Tyr Tyr Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Val Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Thr Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Met Ile Asn His Glu Phe Met Thr Thr Leu Thr Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Asp Lys 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Arg Thr Thr Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Glu Val Tyr His Met 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Ile Arg Ala Leu Thr Gln Ser 
            340                 345                 350         


Phe Cys Gly Gly Asn Arg Pro Glu Asp Arg Pro Leu Leu Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Leu Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Asp Lys Pro Asn Pro Lys Ile Pro Trp Val Asp Trp Arg 
                405                 410                 415     


Leu Arg Val Ala Ser Gln Leu Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Gly Leu Ser Gln 
    450                 455                 460                 


Ala Gln Arg His Ser Ser His Phe Ile Arg Trp Lys Tyr Ala Ala Val 
465                 470                 475                 480 


Asn Ser Thr Pro Lys Pro Leu Gln Asp Tyr Ile His Glu Asn Gly Ala 
                485                 490                 495     


Ser Pro Leu Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Gln Ile Gln Ser 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Gly Ile Tyr Asn His Ser Ala Phe 
    530                 535                 540                 


Leu Glu Asp Leu Ala Tyr Thr Leu Gln Glu Arg Arg Thr Lys Phe Ile 
545                 550                 555                 560 


Trp Lys Ala Ala Val Val Ala Gly Ser Pro Lys Asp Leu Leu Glu Ala 
                565                 570                 575     


Leu Ser Lys Pro Leu Lys Phe Ser Arg Thr Leu Lys Thr Ala Ser Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Arg 
        595                 600                 605             


Asp Leu Met Glu Leu Phe Pro Val Phe Lys Thr Thr Ile Arg Lys Ile 
    610                 615                 620                 


Gly Arg Tyr Leu His Ser Leu Gly Ala Pro Trp Asp Val Glu Asp Glu 
625                 630                 635                 640 


Ile Lys Val Asp Pro Lys Leu Thr Lys Ile Asn Lys Ala Met Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Asp Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Lys Pro Ser Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Trp Arg Gly Val Ser Ser Ser Arg Val Gln Asp Glu 
705                 710                 715                 720 


His Arg Ala Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Asp Asp 
                725                 730                 735     


Ala Thr Lys Tyr Leu Gly Glu Ile Lys Thr Gly Lys Ala Ile Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Ser Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Met Leu Glu Ser Arg Gly Val Phe Ala Arg 
    770                 775                 780                 


Met Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Ala Glu Glu Tyr Ala Lys Ala Ile Ala Gly Ile Arg Thr Arg Gln Ala 
                805                 810                 815     


Asn Gly Val Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Leu Gly Ala 
            820                 825                 830         


Glu Asp Leu Gly Pro Ser Tyr Trp Ile Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Thr Glu Ala Met Lys Gln Leu Cys Leu Ala Pro Ala Leu Gln 
    850                 855                 860                 


Ser Lys Arg Arg Gln Ala Lys Arg His Asn Val Glu Tyr Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Ala Pro Ile Arg Asp Ile Ile Asn 
                885                 890                 895     


Ser Asp Pro Arg Leu Arg Val Ala Asp Val Leu Tyr Ala Ser Ala Leu 
            900                 905                 910         


Val Arg Arg Val Asp Ala Val Arg Thr Val Leu Glu Leu Ala Gly Arg 
        915                 920                 925             


Leu Ser Ala Ile Gly Tyr Gln Val Asn Tyr Ala Ala Met Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Asn Gly Ser Ile Leu Val Asp Leu Pro Thr Tyr Thr 
945                 950                 955                 960 


Trp Asn His Thr Thr Ser Tyr Trp Ala Glu Pro Arg Arg Ser Lys Ala 
                965                 970                 975     


Phe Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Val Arg Asp 
            980                 985                 990         


Asp Asn Ser Asp Pro Met Gln Ile  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Asp  Leu Pro Trp Leu Leu  Gln His Lys Ile Gln  Ser Thr Leu 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Asp Arg  Tyr Ala Lys Lys Leu  Ser Gly Phe 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Ser Ala Leu Leu  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Val Glu Thr Ile  Leu Thr Leu Arg Pro  Ile Arg Asp 
    1070                 1075                 1080             


Thr Ser  Arg Arg His Ser Asp  Thr Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Ile  Thr Asn Glu Asn His  Trp Ser Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Val Gln His Gln Lys  Gln Asn Glu Ser Thr  Lys Glu Thr 
    1115                 1120                 1125             


His Ile  Thr Leu Gln Pro Ala  Val Glu Glu Phe Arg  Thr Ser Val 
    1130                 1135                 1140             


Pro Ile  Pro Asp Phe Tyr Glu  His Leu Ser Ser Ile  Gly Leu Asp 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Lys  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Val Pro Ala Thr  Ala Thr Gly 
    1175                 1180                 1185             


Val Pro  Leu Asp Gln Glu His  Thr Tyr Leu Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Ile Phe Gly Ala Leu  Ser Gly Asp 
    1205                 1210                 1215             


Asn Trp  Leu Gln Asp Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Phe Ile  Ser Ala Asp Met Pro  Phe Gln Ala Gly His  Leu Val Arg 
    1235                 1240                 1245             


Ala Asn  Ala Leu Leu Thr Ala  Lys Glu Asn Gln Ser  Leu Arg Thr 
    1250                 1255                 1260             


Glu Leu  Ile Val Ile Glu Asp  Ser Lys Asn Ala Pro  Ile Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Asp Trp Arg  Phe Ile Pro Arg Pro  Val Glu Gln 
    1280                 1285                 1290             


Asp Glu  Ile Gly Asp Asn His  His Leu Ala Tyr Thr  Val Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Leu Asp Phe Leu  Asp Leu Lys Asn Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Thr Ala Ala Asp Tyr  Leu Arg Leu Leu Ala  Phe Lys Asn 
    1325                 1330                 1335             


Pro Asp  Ile Ser Val Leu Asp  Val Ser Ala Ser Thr  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Asp Ile Gly Asn Ser  Ala Gly Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Arg 
    1370                 1375                 1380             


Ala Ala  Leu Leu Ser Asp Ile  Pro Asp Val Pro Tyr  Asp Leu Met 
    1385                 1390                 1395             


Thr Lys  Lys Ala Leu Asp Val  Glu Ile Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Asp  Leu Lys Thr Phe Asp  Val Ile Ile Val Thr  Ala Ser Leu 
    1415                 1420                 1425             


Ala Glu  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Lys Ser 
    1430                 1435                 1440             


Leu Leu  Lys Pro Asp Gly Arg  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Glu  Gln Asp Pro Val Phe  Leu Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Asn Ala  Gly Phe Met Asp His  Lys Leu Leu Glu Ser  Asp Glu Ser 
    1475                 1480                 1485             


Gly Glu  Arg Val Asp Gln Gly  Thr Met Phe Ile Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Asp  Ser Asn Pro Ala Ser  Pro Glu Leu Leu Val  Met Gly Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Leu Asp  Thr Ser His Leu Ala  Ser Ile Leu 
    1520                 1525                 1530             


Gly Val  Glu Pro Gly Asn Ile  Asp Gln Ser Ser Leu  Tyr Asp Leu 
    1535                 1540                 1545             


Ala Pro  Thr Glu Lys Leu Leu  Met Val Trp Asp Ala  Ser Ala Glu 
    1550                 1555                 1560             


Val Leu  Ser Ser Pro Thr Val  Glu Gln Phe Glu Ala  Ile Lys Arg 
    1565                 1570                 1575             


Leu Phe  Thr Gln Ser Gln Arg  Val Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Ala Gln  Gly Ser Arg Arg Pro  Glu Ser Asn Leu Ile  Ser Gly Leu 
    1595                 1600                 1605             


Gly Arg  Thr Ala Arg Ser Glu  Asn Gly Gly Ala Arg  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Asp  Lys Leu Ser Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Val Leu  Arg Lys Ser Phe Val  Gly Asn Asp 
    1640                 1645                 1650             


Gln Gln  His Leu Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Val 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Thr Ile  Asn Gln Ala 
    1670                 1675                 1680             


Ile Asp  Ser Phe Leu Gln Pro  Thr Ala Lys Glu Met  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Gly Ile Val Tyr  Ser Leu Leu Asp Arg  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Thr Phe Gln  Asp Ile Ala Phe Glu  Glu Glu Leu 
    1715                 1720                 1725             


Asp Glu  Asn Asp Ile Arg Ile  Glu Val Lys Ala Leu  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Gln Val  Leu Thr Gln Asp Leu  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Glu Gln  Val Thr Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Thr  Asn Arg Val Ser Asn  Thr Phe Arg 
    1775                 1780                 1785             


Gly Arg  Ala Thr Ala Phe Gln  Lys Ile Pro Asp Gly  Met Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Phe Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Ile Ala His  Val Ser Arg Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Lys Leu Gly Ala Arg  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Tyr Met Glu  Ser Ala Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Asn Ile  Leu Tyr Asn Asn Glu  Asp Arg Ser Val Ala  Ala Leu Leu 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Met Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Leu  Glu Asn Ser 
    1925                 1930                 1935             


Lys Leu  Asp Leu Ala Asn Phe  Arg Arg Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Thr Arg Leu Gln  Glu Glu Arg Pro Gly  Leu Ala Asp 
    1955                 1960                 1965             


Glu Leu  Trp Gly Gln Thr Leu  Glu Leu Ile Ser Lys  Asp Thr Phe 
    1970                 1975                 1980             


Ser Ser  Thr Leu Pro Asn Val  Gln Val Phe Asn Gly  Glu Ala Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Glu Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Ser Phe Asn Pro  Thr Asp Arg Val Met  Leu Ile Pro 
    2015                 2020                 2025             


Thr Ser  Ser Lys Asp Gln Val  Phe Arg Ala Asp Gly  Thr Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Asp His Gly Ala Arg  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Met  Ser Lys Gln Glu Ala  Lys Ala Thr Val His  Ala Ile Lys 
    2075                 2080                 2085             


Ser Leu  Gly Ala Lys Val His  Leu Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Asp  His Val Arg Gln Leu  Ile Glu Glu Cys Gly  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Leu  Leu Gln Asp 
    2120                 2125                 2130             


Met Ile  Val Asp Lys Ile Thr  Val Asp Asp Trp Asn  Ala Val Ile 
    2135                 2140                 2145             


Lys Pro  Lys Val His Gly Thr  Phe Asn Leu His Asn  His Leu Pro 
    2150                 2155                 2160             


Arg Asp  Met Asp Phe Phe Ile  Val Leu Ser Ser Ile  Ser Gly Leu 
    2165                 2170                 2175             


Met Gly  Asn Thr Thr Gln Ala  Ala Tyr Ala Ala Gly  Asn Ser Phe 
    2180                 2185                 2190             


Leu Asp  Gly Phe Ser Gly Tyr  Arg Asn Ala Gln Gly  Leu Pro Gly 
    2195                 2200                 2205             


Val Ser  Leu Asp Leu Gly Ala  Ile Thr Gly Val Gly  Tyr Val Ala 
    2210                 2215                 2220             


Ser Glu  Asp Asn Lys Gln Met  Ser Arg Ser Leu Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Thr  Met Thr Gly Glu Lys  Leu Val Leu Ala Ile  Ile Arg Ser 
    2240                 2245                 2250             


Gly Ile  Met Glu Pro Phe Gly  Arg Ala Ala Lys Thr  Gln Thr Val 
    2255                 2260                 2265             


Thr Gly  Val Gly Thr Trp Arg  Ser Ala Arg Ser Leu  Ser Ala Leu 
    2270                 2275                 2280             


Glu Asn  Ser Ile Phe Ser His  Tyr Lys Arg His Ser  Lys Glu Gly 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Glu  Gln Thr Thr Asn Gly  Lys Leu Ser 
    2300                 2305                 2310             


Leu Arg  Asp Ala Leu Lys Ser  Ser Glu Thr Leu Asp  Asp Ala Ala 
    2315                 2320                 2325             


Ala Leu  Ile Cys Asn Gly Leu  Ile Gly Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Ala Met  Ser Val Asp Asn Phe  Ser Thr Asp Leu Ser  Leu Ser Glu 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Ser  Ile Pro Leu Leu Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Thr Gln Leu  Ser Val Glu Ile Ala  Ser Lys Ser 
    2390                 2395                 2400             


Arg Leu  Val Pro Val Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  252
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  252

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Gln Gly Lys Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Lys 
        35                  40                  45              


Leu Ile Cys Glu Lys Arg Glu Ser Arg Thr Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Arg Gly Phe Tyr His Pro Asn Phe Asn Arg His Gly Thr 
65                  70                  75                  80  


His Asn Val Asp Trp Gly His Phe Phe His Glu Asp Ile Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Thr Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Leu Asp Lys Leu Val Gly Ser Arg Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Phe Ala Thr Asp Tyr Thr Asp Ile Leu Thr Arg Glu Pro 
145                 150                 155                 160 


Glu Ser Ile Pro Met Phe Asn Cys Thr Asn Ser Gly Asn Ser Arg Ala 
                165                 170                 175     


Ile Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Met Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Met Leu Gln His Glu Phe Met Thr Thr Met Ser Met 
225                 230                 235                 240 


Met Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Ile Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Ser Thr Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Ser Asn Ser 
            340                 345                 350         


Phe Cys Gly Ala Asn Arg Pro Glu Asp Arg Pro Leu Val Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Asp Arg Pro Asn Pro Lys Ile Pro Phe Leu Asp Trp Lys 
                405                 410                 415     


Leu Lys Val Ala Thr Asn Val Gln Pro Trp Asp Thr Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Ser Tyr Leu Thr Ser Arg Gly Val Ser Asn 
    450                 455                 460                 


Gly Gln Lys His Ser Ser His Phe Ile Arg Tyr Lys Tyr Gly Ala Ile 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Ile Gln Glu Tyr Val His Asp Asn Gly Gly 
                485                 490                 495     


Ser Pro Leu Asp Ser Pro Val Pro Asn Trp Thr His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Gln Asn Ile Gln Thr 
        515                 520                 525             


Leu Val Arg His Leu His Glu Arg Ala Ile Phe Asn His Thr Gly Tyr 
    530                 535                 540                 


Leu Asp Asp Leu Ala Trp Thr Leu Asn Glu Arg Arg Ser Lys Phe Ile 
545                 550                 555                 560 


Tyr Lys Gly Ala Val Val Ala Ala Ser Pro Lys Glu Leu Leu Glu Ala 
                565                 570                 575     


Leu Thr Lys Pro Ile Lys Phe Thr Arg Thr Ile Lys Ser Ala Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Lys 
        595                 600                 605             


Asp Leu Leu Glu Val Phe Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Arg Tyr Leu His Ser Ile Gly Ala Pro Trp Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Lys Met Glu Pro Lys Val Ser Lys Ile Asn Arg Ala Leu Phe Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Arg Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Val Ser Ser Ser Lys Ile Gln Glu Glu 
705                 710                 715                 720 


His Lys Gly Asn Gly Ala Met Met Ala Ala Ala Leu Ser Glu Glu Asp 
                725                 730                 735     


Ala Ser Arg Tyr Leu Ala Glu Leu Lys Ser Gly Lys Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Thr Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Glu Leu Gln Lys Val Leu Glu Ser Arg Gly Val Phe Ala Arg 
    770                 775                 780                 


Ile Leu Ala Val Glu Val Ala Tyr His Ser His His Met Asp Leu Val 
785                 790                 795                 800 


Ala Glu Asp Tyr Ala Lys Ala Ile Gly Gly Ile Arg Thr Arg Asn Ala 
                805                 810                 815     


Asn Ala Ile Lys Trp Tyr Ser Ser Val Tyr Gly Arg Asp Ile Ala Gly 
            820                 825                 830         


Asp Asp Met Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Ser Asp Ala Met Lys Asn Leu Cys Leu Ala Pro Ala Ile Gln 
    850                 855                 860                 


Ser Lys Arg Lys Gln Ala Arg Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Lys Asp Ile Leu Gln 
                885                 890                 895     


Ser Asp Pro Arg Val Arg Leu Ala Asp Leu Met Phe Ala Ser Ala Leu 
            900                 905                 910         


Ile Arg Lys Val Asp Ala Leu Arg Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Leu Gly Tyr Gln Val Asn Tyr Ala Ala Leu Asn Arg Pro 
    930                 935                 940                 


Thr Ala Asp His Gln Ala Thr Val Leu Val Asp Leu Pro Thr Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Ser Ser Tyr Trp Ala Glu Pro Arg Arg Thr Lys Ala 
                965                 970                 975     


Trp Arg Asn Arg Ile Phe Pro Arg Val Asp Ile Leu Gly Leu Arg Asp 
            980                 985                 990         


Glu Asn Ser Glu Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Asp  Leu Pro Trp Leu Leu  Gln His Arg Ile Gln  Ser Thr Ile 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Lys  Phe Gly Lys Lys Ile  Thr Gly Tyr 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Ser Ala Leu Ile  Leu Pro Asp 
    1055                 1060                 1065             


Gln Glu  Thr Leu Asp Thr Ile  Leu Ser Leu Lys Pro  Ile Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Arg His Ser Asp  Ser Trp Thr Asp Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Val  Ser Gln Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Val Gln His Asn Lys  Gln Gln Glu Thr Ser  Arg Glu Ser 
    1115                 1120                 1125             


His Leu  Ser Ile Gln Pro Ala  Ile Asp Glu Phe Lys  Thr Ser Leu 
    1130                 1135                 1140             


Pro Leu  Pro Glu Phe Tyr Glu  His Leu Ser Ser Leu  Gly Leu Asp 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Glu Ala Arg  Ser Thr Pro 
    1160                 1165                 1170             


Asp Arg  Val Thr Gly Ile Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Glu His  Thr Tyr Leu Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Ile Phe Ala Ala Leu  Ser Ala Glu 
    1205                 1210                 1215             


Asn Trp  Leu Gln Asp Ser Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Trp Ile  Ser Ala Asp Leu Pro  Phe Gln Gly Gly His  Leu Leu Lys 
    1235                 1240                 1245             


Ala Asn  Gly Val Ile Thr Ala  Arg Asp Asn Gln Ser  Leu Lys Thr 
    1250                 1255                 1260             


Asp Val  Ile Val Ile Asp Asp  Ser Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Thr  Glu Leu Asp Phe Arg  Phe Val Pro Arg Pro  Val Glu Gln 
    1280                 1285                 1290             


Asp Asp  Val Ala Asp Asn His  His Leu Ala Tyr Thr  Val Asp Trp 
    1295                 1300                 1305             


Asp Ala  Glu Leu Asp Phe Leu  Asp Met Lys Asn Thr  Gln Gln Leu 
    1310                 1315                 1320             


Pro His  Ser Ala Ala Asp Phe  Leu Arg Val Leu Ala  Phe Arg Asn 
    1325                 1330                 1335             


Pro Glu  Val Ser Val Leu Asp  Val Ser Ala Ser Thr  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Glu Leu Gly Asn Ser  Gly Ala Lys 
    1355                 1360                 1365             


Gln Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Arg 
    1370                 1375                 1380             


Ala Ala  Leu Val Ser Asp Leu  Pro Asp Leu Pro Tyr  Asp Ile Met 
    1385                 1390                 1395             


Thr Lys  Lys Gly Leu Asp Ile  Glu Ile Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Asp  Leu Lys Ser Phe Asp  Val Ile Ile Val Ser  Ala Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Gln Pro His  Lys Ala Leu Gly His  Ile Arg Ser 
    1430                 1435                 1440             


Leu Leu  Lys Pro Asp Gly Lys  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Met Asp  Gln Asp Pro Val Phe  Leu Gln Trp Lys Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Met Asp His  Lys Ile Val Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Glu  Arg Leu Asp Gln Gly  Ser Val Phe Val Gly  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Thr Asn Pro Ala Thr  Pro Glu Ile Leu Val  Met Gly Asp 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Ile Glu  Thr Ser His Leu Ala  Thr Leu Leu 
    1520                 1525                 1530             


Gly Leu  Glu Pro Ala Asn Val  Asp Gln Thr Ser Leu  Tyr Glu Leu 
    1535                 1540                 1545             


Ala Pro  Thr Glu Lys Val Leu  Val Val Trp Asp Ala  Ser Ala Glu 
    1550                 1555                 1560             


Val Leu  Thr Ser Pro Ser Leu  Glu Gln Phe Glu Gly  Ile Lys Arg 
    1565                 1570                 1575             


Leu Phe  Thr Gln Ser Asn Lys  Leu Leu Trp Val Thr  Ser Gly Arg 
    1580                 1585                 1590             


Gly Asn  Gly Ser Arg Arg Pro  Glu Ser Asn Leu Ile  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Thr Glu  Asn Gly Gly Ala Lys  Leu Ile Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Asp Glu Glu  Lys Leu Thr Arg Asn  Asp Ala Thr 
    1625                 1630                 1635             


Asn Val  Ile Ser Ala Val Ile  Lys Arg Ser Trp Leu  Gly Asn Glu 
    1640                 1645                 1650             


Asn Gln  His Val Ala Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Ile 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Glu Thr Leu  Asn Asn Ala 
    1670                 1675                 1680             


Ile Asp  Ser Tyr Leu Gln Pro  Thr Ala Lys Glu Leu  Gln Ile Val 
    1685                 1690                 1695             


His His  Lys Ala Ile Val Trp  Thr Leu Leu Asp Arg  Thr Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Ile Ala Tyr Glu  Asp Glu Leu 
    1715                 1720                 1725             


Glu Asp  Asn Glu Ile Arg Ile  Asp Val Arg Ala Met  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Asn Arg Val Asn Ile  Ile Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Asp Asn  Val Thr Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Leu Ser  Asn Arg Val Ser Asn  Ser Tyr Arg 
    1775                 1780                 1785             


Gly Arg  Ala Ser Ala Phe Gln  Arg Ile Pro Asp Gly  Leu Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Tyr Arg Val Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Arg Val Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Glu 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Ser Ala Leu His Phe  Pro Lys Glu 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Glu  Glu Arg Ser Val Ala  Gly Leu Met 
    1880                 1885                 1890             


Ala Asn  Thr Gln Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Leu Leu Gln Ser  Cys Trp Asn Cys Ile  Ala Pro Tyr 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Met  Glu Asn Ser 
    1925                 1930                 1935             


Arg Leu  Glu Ile Ala Asn Phe  Arg Lys Asn Thr Ser  Phe Ser Gly 
    1940                 1945                 1950             


Leu Asn  Leu Thr Arg Leu Gln  Glu Glu Lys Pro Ala  Val Ala Asp 
    1955                 1960                 1965             


Glu Leu  Trp Gly Gln Thr Val  Asp Leu Ile Ser Lys  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Ile  Gln Val Phe Asn Ala  Asp Gly Ile 
    1985                 1990                 1995             


Ser Asn  Ala Phe Glu Arg Leu  Met Asp Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Ser Phe Asn Pro  Ser Asp Arg Val Met  Ile Ile Pro 
    2015                 2020                 2025             


Ser Ser  Ser Lys Asp Gln Val  Phe Arg Ala Asp Ala  Thr Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Lys Ala Thr  Ala Thr Tyr 
    2045                 2050                 2055             


Met Val  Glu His Gly Ala Arg  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Met  Ser Lys Gln Asp Ala  Arg Ala Thr Val His  Ala Val Arg 
    2075                 2080                 2085             


Ser Leu  Gly Ala Lys Leu His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Arg Gln Leu  Ile Glu Glu Cys Gly  Thr Asn Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Leu Gln Asp 
    2120                 2125                 2130             


Met Leu  Leu Glu Lys Met Thr  Val Asp Asp Phe Gln  Ala Met Met 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Ser  Trp Asn Leu His Gln  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Tyr Phe Ile  Leu Leu Ser Ser Ile  Ser Gly Val 
    2165                 2170                 2175             


Val Gly  Gln Thr Thr Gln Gly  Ala Tyr Ala Ala Gly  Asn Ser Phe 
    2180                 2185                 2190             


Leu Asp  Ala Phe Ser Gly Tyr  Arg Asn Ala Gln Gly  Leu Pro Gly 
    2195                 2200                 2205             


Val Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Ile Gly  Phe Val Ala 
    2210                 2215                 2220             


Thr Asp  Glu Asn Lys Asn Leu  Ser Arg Thr Val Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Thr  Ile Thr Gly Glu Lys  Leu Leu Val Gly Leu  Ile Arg Thr 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Lys Ala Gly Lys Ser  Gln Thr Ile 
    2255                 2260                 2265             


Thr Gly  Val Ala Thr Trp Lys  Ser Gly Arg Ser Met  Ser Ala Ile 
    2270                 2275                 2280             


Glu Asn  Ser Met Phe Ser His  Phe Arg Arg His Ser  Lys Glu Gly 
    2285                 2290                 2295             


Glu Val  Ile Ala Glu Lys Glu  Gln Ser Ser Asn Ala  Arg Val Ser 
    2300                 2305                 2310             


Val Lys  Asp Ala Leu Arg Ser  Ser Asp Ser Leu Glu  Asp Gly Ala 
    2315                 2320                 2325             


Ala Val  Ile Cys Gln Ala Leu  Val Ala Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Gly Ile  Ser Val Asp Asn Phe  Ser Ser Glu Met Ser  Leu Ser Asp 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Asp Leu Glu Ser Ser  Ile Pro Leu Leu Glu  Leu Leu Ala 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Val Asp Ile Ala  Ser Arg Thr 
    2390                 2395                 2400             


Arg Val  Val Pro Val Glu Ile  Arg Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  253
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  253

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Ile Asn 
1               5                   10                  15      


His Gln Gly Lys Glu Glu Gly Thr Val Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Asp Gln Leu Phe Lys 
        35                  40                  45              


Leu Ile Cys Asp Lys Arg Glu Thr Arg Ser Ala Ile Pro Lys Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Phe Tyr His Pro Asn Phe Gln Arg His Gly Thr 
65                  70                  75                  80  


His Asn Val Glu Tyr Gly His Phe Phe His Asp Asp Val Ser Arg Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Thr Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Leu Pro Val Asp Lys Ile Val Gly Ser Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Ser Tyr Gly Thr Asp Tyr Thr Glu Met Leu Thr Lys Glu Pro 
145                 150                 155                 160 


Glu Ser Leu Pro Val Tyr Gln Cys Ser Asn Thr Gly Gln Ser Lys Ala 
                165                 170                 175     


Leu Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Leu Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Met 
        195                 200                 205             


Ala Cys Asn Ser Leu Arg Ala Gly Glu Ala Lys Ser Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Met Leu Asn His Glu Phe Met Thr Thr Leu Thr Met 
225                 230                 235                 240 


Leu Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Asp Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Arg Thr Thr Gly Ile Thr Leu 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Val 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Asp Thr Thr Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Arg Ala Leu Thr Asn Ser 
            340                 345                 350         


Phe Cys Ala Ala Asn Arg Pro Asp Glu Arg Pro Leu Leu Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Ile Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Asp Lys Pro Asn Pro Lys Ile Pro Trp Val Glu Phe Lys 
                405                 410                 415     


Leu Arg Val Ala Ser Gln Val Gln Pro Trp Asp Ser Ser Gly Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Tyr Leu Thr Ser Arg Ala Val Thr Asn 
    450                 455                 460                 


Ala Gln Arg His Ser Thr His Phe Val Arg Tyr Lys Tyr Gly Ala Leu 
465                 470                 475                 480 


Asn Thr Thr Pro Lys Pro Leu Asn Glu Phe Leu His Glu Asn Gly Gly 
                485                 490                 495     


Ser Pro Val Asp Ser Pro Val Pro Asn Tyr Ser His Pro Lys Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Asp Pro Thr Ala Gln Gln Asn Ile Asn Thr 
        515                 520                 525             


Leu Val Lys His Leu His Glu Arg Ala Ile Phe Asn His Ser Gly Phe 
    530                 535                 540                 


Leu Asp Asp Leu Ala Phe Thr Leu Asn Glu Arg Arg Ser Arg Phe Ile 
545                 550                 555                 560 


Tyr Lys Ala Ala Val Val Ala Gly Ser Pro Lys Glu Leu Ile Asp Ala 
                565                 570                 575     


Leu Ser Lys Pro Ile Lys Phe Ser Lys Thr Val Lys Ser Ala Ser Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Arg 
        595                 600                 605             


Glu Leu Leu Asp Ile Tyr Pro Val Phe Lys Thr Thr Ile Arg Arg Ile 
    610                 615                 620                 


Gly Lys Phe Leu His Ser Leu Gly Ala Pro Trp Asp Val Glu Asp Glu 
625                 630                 635                 640 


Ile Lys Leu Glu Pro Lys Val Ser Arg Ile Asn Lys Ala Leu Phe Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Asp Leu Leu Ala 
            660                 665                 670         


Ser Trp Asn Ile Lys Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Thr Ala Ala Tyr Tyr Arg Gly Leu Ser Ser Ser Arg Met Gln Glu Glu 
705                 710                 715                 720 


His Lys Gly Asn Gly Ala Met Met Ala Ala Gly Leu Ser Glu Glu Glu 
                725                 730                 735     


Ala Thr Arg Phe Leu Gly Asp Leu Lys Ser Gly Arg Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Thr Ser Val Thr Ile Ser Gly Asp Val Ser Ala 
        755                 760                 765             


Val Ser Asp Leu Gln Lys Ile Leu Glu Ser Arg Gly Val Phe Ala Arg 
    770                 775                 780                 


Leu Leu Ala Val Glu Val Ala Tyr His Ser His His Met Glu Ile Val 
785                 790                 795                 800 


Ala Asp Asp Tyr Ala Lys Ala Ile Gly Gly Ile Lys Thr Lys Asn Gly 
                805                 810                 815     


Asn Gly Ile Lys Trp Phe Ser Ser Val Tyr Gly Arg Asp Ile Gly Ala 
            820                 825                 830         


Glu Glu Leu Gly Pro Ser Tyr Trp Ile Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Ser Glu Ala Met Arg Gln Leu Cys Leu Ala Pro Gly Leu Gln 
    850                 855                 860                 


Ser Lys Lys Arg Gln Ala Arg Arg His Asn Val Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Gly Gly Pro Ile Arg Glu Ile Leu Gln 
                885                 890                 895     


Thr Asp Pro Lys Met Arg Leu Ala Asp Ile Val Tyr Ala Ser Ala Leu 
            900                 905                 910         


Ile Arg Lys Val Glu Ala Leu Lys Ser Val Leu Asp Leu Ala Gly Arg 
        915                 920                 925             


Leu Ser Gly Leu Gly Phe Asn Val Asn Tyr Ala Ala Ile Asn Arg Pro 
    930                 935                 940                 


Thr Gly Asp His Asn Gly Ser Val Val Val Asp Leu Pro Thr Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Thr Ser Tyr Trp Ala Glu Pro Lys Arg Ser Arg Ala 
                965                 970                 975     


Tyr Lys Asn Arg Val Tyr Pro Lys Val Asp Ile Leu Gly Ile Arg Asp 
            980                 985                 990         


Glu Gln Ser Asp Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Thr 
        995                 1000                 1005             


Ser Glu  Val Pro Trp Leu Leu  Gln His Lys Ile Asn  Ser Ser Ile 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Ala 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Glu Arg  Phe Gly Arg Lys Leu  Thr Gly Phe 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Ala Ser Ala Leu Val  Leu Pro Glu 
    1055                 1060                 1065             


Gln Glu  Ser Val Glu Thr Val  Leu Thr Leu Arg Pro  Leu Arg Glu 
    1070                 1075                 1080             


Ser Ser  Arg Lys His Thr Glu  Ser Trp Ser Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Ile  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Leu Gln His Gln Arg  Gln Gln Glu Ser Thr  Arg Asp Thr 
    1115                 1120                 1125             


His Met  Thr Val Gln Pro Ala  Val Asp Glu Tyr Arg  Thr Ser Ile 
    1130                 1135                 1140             


Pro Val  Pro Asp Phe Tyr Asp  His Leu Ser Ser Leu  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Ile Asp Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Glu Arg  Val Thr Gly Val Leu  Lys Ile Pro Gly Thr  Ala Ser Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Asn Glu His  Thr Phe Ile Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Ser  Leu Phe Ala Gly Met  Ser Gly Asp 
    1205                 1210                 1215             


Gln Trp  Leu Gln Glu Ser Ala  Ile Pro Ile Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Trp Ile  Ser Ala Asp Leu Pro  Phe Gln Gly Gly His  Leu Leu Arg 
    1235                 1240                 1245             


Ala Gln  Ala Val Leu Ser Ala  Arg Glu Gln Gln Ser  Leu Lys Thr 
    1250                 1255                 1260             


Asp Val  Ile Val Ile Asp Asp  Thr Lys Asn Ala Pro  Leu Val Gln 
    1265                 1270                 1275             


Phe Ser  Glu Leu Glu Phe Lys  Phe Ile Pro Arg Pro  Val Glu Gln 
    1280                 1285                 1290             


Asp Asp  Ile Ala Asp Gln His  His Leu Ala Trp Thr  Leu Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Val Glu Phe Met  Asp Val Lys Gln Thr  Gln Gln Ile 
    1310                 1315                 1320             


Pro His  Thr Ala Ala Glu Tyr  Leu Lys Leu Leu Ala  Phe Arg Gln 
    1325                 1330                 1335             


Pro Asp  Leu Ser Val Leu Asp  Val Ser Ala Ser Thr  Ser Ser Ile 
    1340                 1345                 1350             


Leu Ser  Phe Leu Lys Ala Leu  Glu Ile Gly Gln Ser  Gly Gly Lys 
    1355                 1360                 1365             


Gln Arg  Cys Lys Ala Tyr Thr  Val Ala His Pro Gln  Lys Asn Arg 
    1370                 1375                 1380             


Ala Ala  Leu Leu Ser Asp Val  Pro Asp Ile Pro Tyr  Asp Ile Leu 
    1385                 1390                 1395             


Ser Lys  Arg Ala Leu Asp Ile  Glu Leu Gly Pro Gln  Thr Pro Asp 
    1400                 1405                 1410             


Phe Asp  Leu Lys Ser Phe Asp  Val Ile Ile Val Thr  Gly Ser Leu 
    1415                 1420                 1425             


Ala Asp  Phe Asn Asn Pro His  Lys Ala Leu Gly His  Ile Arg Ser 
    1430                 1435                 1440             


Leu Leu  Lys Pro Asp Gly Lys  Leu Ile Val Leu His  Glu Ala Ser 
    1445                 1450                 1455             


Met Asp  Gln Asp Pro Leu Phe  Val Gln Trp Lys Thr  Thr Leu Gln 
    1460                 1465                 1470             


Asn Ala  Gly Phe Met Asp His  Lys Leu Val Glu Ser  Glu Glu Ser 
    1475                 1480                 1485             


Gly Asp  Arg Val Glu Asn Ala  Ser Met Phe Ile Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Glu  Thr Gln Pro Ala Ser  Pro Glu Ile Val Val  Met Gly Asp 
    1505                 1510                 1515             


Asp His  Gln Gln Thr Val Asp  Thr Thr His Leu Ala  Ser Ile Leu 
    1520                 1525                 1530             


Gly Met  Glu Pro Ala Gln Val  Glu Gln Thr Thr Leu  Tyr Glu Ile 
    1535                 1540                 1545             


Ala Pro  Thr Glu Lys Leu Leu  Ile Val Trp Asp Ala  Ser Gly Glu 
    1550                 1555                 1560             


Val Leu  Thr Thr Pro Ser Ile  Glu Gln Phe Glu Gly  Ile Lys Arg 
    1565                 1570                 1575             


Leu Phe  Ser Gln Ser Asn Lys  Ile Leu Trp Val Thr  Thr Gly Arg 
    1580                 1585                 1590             


Ala Gln  Ala Ser Arg Arg Pro  Glu Ser Asn Leu Leu  Thr Gly Leu 
    1595                 1600                 1605             


Gly Arg  Thr Ala Arg Ser Glu  Gln Gly Ala Ala Lys  Leu Leu Ser 
    1610                 1615                 1620             


Leu Asp  Leu Asp Glu Asp Asp  Arg Ile Ser Arg Asn  Glu Ala Thr 
    1625                 1630                 1635             


Asn Ile  Ile Ser Gly Leu Ile  Arg Arg Thr Phe Met  Gly Asn Glu 
    1640                 1645                 1650             


Gln Gln  His Met Gly Glu Ser  Glu Tyr Val Glu Arg  Lys Gly Leu 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Glu Ser Val  Asn Gln Ala 
    1670                 1675                 1680             


Met Asp  Ser Tyr Val Asn Pro  Thr Ala Lys Glu Leu  Gln Leu Leu 
    1685                 1690                 1695             


His His  Lys Ala Ile Leu Tyr  Ser Leu Leu Asp Lys  Ser Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Leu Ala Tyr Asp  Glu Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Asp Ile Arg Ile  Asp Val Arg Ala Val  Thr Leu Val 
    1730                 1735                 1740             


Thr Gly  Asn Arg Val Asn Met  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Val  Lys Val Gly Asp Asn  Val Thr Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Leu Ser  Asn Arg Leu Ser Asn  Ser Tyr Lys 
    1775                 1780                 1785             


Gly Lys  Ala Ser Ala Phe Gln  Arg Ile Pro Asp Ala  Met Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Tyr Tyr 
    1805                 1810                 1815             


Ala Met  Phe Lys Met Ala His  Val Ser Lys Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Glu Leu 
    1835                 1840                 1845             


Cys Gly  Arg Leu Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Glu 
    1850                 1855                 1860             


Lys Glu  Ala Phe Tyr Met Glu  Ser Ala Leu His Phe  Pro Arg Glu 
    1865                 1870                 1875             


Gln Ile  Ile Tyr Asn Asn Asp  Glu Arg Ser Val Ala  Ala Leu Ile 
    1880                 1885                 1890             


Gly Asn  Thr Asn Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Met Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Phe 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Leu Val  Glu Asn Thr 
    1925                 1930                 1935             


Arg Leu  Glu Met Ala Asn Phe  Lys Arg Asn Thr Ser  Phe Ser Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Asn  Glu Glu Lys Pro Ala  Ile Ala Asp 
    1955                 1960                 1965             


Glu Ile  Trp Ala Gln Thr Leu  Asp Leu Ile Ser Arg  Asp Ser Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Val  Gln Ile Phe Asn Ala  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Asp Glu Asp Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Phe Asn Pro  Ser Glu Arg Val Leu  Ile Ile Pro 
    2015                 2020                 2025             


Thr Thr  Ser Lys Asp Gln Val  Phe Lys Ala Glu Gly  Thr Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Lys Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Asp His Gly Ala Lys  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Ala Ile  Thr Lys Gln Glu Ala  Lys Ala Thr Val His  Gly Leu Lys 
    2075                 2080                 2085             


Ser Ile  Gly Gly Arg Leu His  Val Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Arg Gln Val  Ile Glu Glu Cys Ala  Ser Gln Met 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Val  Met Gln Glu 
    2120                 2125                 2130             


Met Met  Met Glu Lys Met Thr  Val Asp Asp Trp Gln  Ala Val Leu 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Ser  Phe Gln Leu His Gln  His Leu Pro 
    2150                 2155                 2160             


Arg Asp  Met Asp Phe Phe Ile  Met Leu Ser Ser Val  Ser Gly Leu 
    2165                 2170                 2175             


Val Gly  Asn Ser Thr Gln Ala  Gly Tyr Ala Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Glu  Gly Phe Ser Ala Phe  Arg Asn Ala Gln Gly  Leu Pro Gly 
    2195                 2200                 2205             


Ile Thr  Leu Asp Leu Gly Ala  Ile Ser Gly Val Gly  Phe Val Ala 
    2210                 2215                 2220             


Thr Asp  Glu Asn Arg Asn Met  Ser Lys Thr Met Gln  Glu Asn Gly 
    2225                 2230                 2235             


Phe Ser  Leu Thr Gly Glu Lys  Leu Val Leu Ala Val  Ile Lys Ser 
    2240                 2245                 2250             


Ala Ile  Val Glu Pro Phe Gly  Arg Gly Gly Lys Thr  Gln Thr Ile 
    2255                 2260                 2265             


Thr Gly  Ile Ala Ser Phe Lys  Thr Ala Arg Ser Val  Ser Ala Ile 
    2270                 2275                 2280             


Asp Gln  Ser Leu Phe Ser His  Tyr Arg Lys His Ser  Lys Glu Ala 
    2285                 2290                 2295             


Asp Val  Ile Ala Asp Arg Glu  Gln Thr Ser Gln Ala  Lys Val Ser 
    2300                 2305                 2310             


Ile Arg  Glu Ala Leu Arg Ser  Thr Asp Ser Ile Asp  Asp Ala Ala 
    2315                 2320                 2325             


Gly Ile  Ile Cys Asn Ala Leu  Ile Gly Tyr Leu Ala  Thr Arg Ser 
    2330                 2335                 2340             


Gly Met  Ser Met Asp Gln Phe  Ser Ser Glu Met Ser  Leu Thr Asp 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Glu Leu Glu Ser Thr  Ile Pro Ile Ile Glu  Leu Leu Gly 
    2375                 2380                 2385             


Gln His  Pro Leu Thr Gln Leu  Ser Val Glu Ile Ala  Ser Arg Ser 
    2390                 2395                 2400             


Arg Leu  Val Pro Val Glu Ile  Lys Ser Lys Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  254
<211>  2421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 244

<400>  254

Met Ala Pro Phe Leu Asp Asp Asn Leu Gly Ala Ser Ser Gly Leu Asn 
1               5                   10                  15      


His Asn Gly Lys Glu Asp Gly Ser Met Pro Ile Ala Ile Val Gly Met 
            20                  25                  30          


Ser Phe Arg Gly Pro Gly Ser Ala Asn Asn Ile Glu Asn Leu Phe Arg 
        35                  40                  45              


Ile Ile Cys Glu Lys Arg Glu Ser Arg Ser Ala Ile Pro Arg Ser Arg 
    50                  55                  60                  


Trp Asn Asn Lys Ala Tyr Tyr His Pro Asn Phe Asn Lys His Gly Thr 
65                  70                  75                  80  


His Asn Leu Glu Phe Gly His Phe Phe His Glu Asp Leu Ser Lys Phe 
                85                  90                  95      


Asp Ala Pro Phe Phe Asn Met Thr Lys Glu Glu Ala Ala Ala Leu Asp 
            100                 105                 110         


Pro Ala Gln Arg Leu Leu Leu Glu Ser Thr Tyr Glu Ala Leu Glu Asn 
        115                 120                 125             


Gly Gly Ile Pro Met Asp Arg Leu Val Gly Ser Lys Thr Ser Val Phe 
    130                 135                 140                 


Val Gly Thr Phe Ala Ser Asp Tyr Thr Glu Leu Met Ser Arg Asp Pro 
145                 150                 155                 160 


Glu Ser Ile Pro Val Tyr Asn Cys Thr Asn Ser Gly Asn Ser Lys Ala 
                165                 170                 175     


Ile Ile Ser Asn Arg Leu Ser Tyr Phe Phe Asp Leu His Gly Pro Ser 
            180                 185                 190         


Val Thr Val Asp Thr Ala Cys Ser Gly Ser Leu Val Ala Leu His Leu 
        195                 200                 205             


Ala Cys Gln Ser Leu Arg Ala Gly Glu Ala Lys Thr Ala Ile Ala Ala 
    210                 215                 220                 


Gly Val Asn Val Met Met Asn His Glu Phe Ile Thr Thr Leu Ser Met 
225                 230                 235                 240 


Leu Lys Phe Leu Ser Pro Asp Gly Arg Cys Tyr Ala Phe Asp Glu Arg 
                245                 250                 255     


Gly Asn Gly Tyr Gly Arg Gly Glu Gly Val Gly Thr Val Phe Leu Lys 
            260                 265                 270         


Pro Leu Ala Asp Ala Leu Lys Asp Gly Asp Pro Ile Arg Ala Val Ile 
        275                 280                 285             


Arg Gly Ser Ala Ser Asn Gln Asp Gly Lys Thr Thr Gly Ile Thr Val 
    290                 295                 300                 


Pro Asn Pro Val Ala Gln Glu Ala Leu Ile Lys Asp Val Tyr His Met 
305                 310                 315                 320 


Ala Asp Leu Asn Pro Ile Glu Thr Ser Ile Val Glu Ala His Gly Thr 
                325                 330                 335     


Gly Thr Ala Ala Gly Asp Pro Leu Glu Leu Lys Ala Leu Ser Gln Ser 
            340                 345                 350         


Phe Cys Ala Ala Asn Arg Pro Asp Asp Lys Pro Leu Ile Ile Gly Ser 
        355                 360                 365             


Ile Lys Ser Asn Leu Gly His Leu Glu Gly Ala Ser Gly Ile Ala Ala 
    370                 375                 380                 


Val Val Lys Ala Val Leu Met Leu Glu Gln Glu Val Ile Leu Pro Asn 
385                 390                 395                 400 


Gln Asn Phe Asp Arg Pro Asn Pro Arg Ile Pro Trp Val Glu Trp Lys 
                405                 410                 415     


Leu Arg Val Gly Thr Asn Leu Gln Pro Trp Asp Thr Thr Ala Pro Leu 
            420                 425                 430         


Arg Val Ser Ile Asn Ser Phe Gly Tyr Gly Gly Ser Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Thr Arg Thr Phe Leu Thr Ser Arg Ala Leu Thr Gln 
    450                 455                 460                 


Gly Gln Lys His Ser Thr His Phe Val Arg Trp Lys Trp Gly Ala Leu 
465                 470                 475                 480 


Asn Ser Ser Pro Lys Pro Leu Asn Glu Phe Ile His Glu Asn Gly Ala 
                485                 490                 495     


Thr Pro Ile Glu Ser Pro Leu Pro Gln Tyr Ser His Pro Arg Leu Phe 
            500                 505                 510         


Thr Leu Ser Val Phe Asp Glu Pro Thr Ala Gln Asn Gln Ile Gln Thr 
        515                 520                 525             


Leu Leu Lys His Leu His Glu Arg Gly Val Tyr Asn His Thr Gly Phe 
    530                 535                 540                 


Leu Glu Asp Leu Ala Trp Thr Leu Gln Glu Arg Arg Ser Lys Phe Ile 
545                 550                 555                 560 


Tyr Lys Ala Ala Val Val Ala Ala Ser Pro Lys Asp Leu Leu Asp Ala 
                565                 570                 575     


Leu Ser Arg Pro Val Lys Phe Ser Arg Thr Leu Lys Thr Gly Thr Leu 
            580                 585                 590         


Gly Phe Val Phe Thr Gly Gln Gly Ala Gln Trp Cys Gly Met Ala Arg 
        595                 600                 605             


Asp Leu Leu Glu Val Tyr Pro Leu Phe Lys Thr Ser Ile Arg Lys Ile 
    610                 615                 620                 


Ala Lys Tyr Leu His Ser Leu Gly Ala Pro Trp Asp Val Glu Glu Glu 
625                 630                 635                 640 


Ile Lys Met Asp Pro Lys Val Ser Arg Ile Asn Arg Ala Leu Tyr Ser 
                645                 650                 655     


Gln Pro Met Cys Ser Ala Val Gln Ile Ala Leu Val Glu Leu Leu Ala 
            660                 665                 670         


Ser Phe Asn Ile Lys Pro Thr Ser Val Thr Gly His Ser Ser Gly Glu 
        675                 680                 685             


Ile Ala Ser Ala Tyr Ala Ile Gly Ala Leu Ser Leu Glu Asp Ala Met 
    690                 695                 700                 


Ser Ala Ala Tyr Tyr Arg Gly Val Ser Ser Ser Lys Val Gln Glu Glu 
705                 710                 715                 720 


His Arg Gly Asn Gly Ala Met Met Ala Ala Ala Leu Ser Glu Glu Glu 
                725                 730                 735     


Ala Thr Arg Phe Leu Gly Asp Leu Lys Ser Gly Lys Ala Val Val Ala 
            740                 745                 750         


Cys Ser Asn Ser Pro Thr Ser Val Thr Ile Ser Gly Glu Val Ser Ala 
        755                 760                 765             


Val Thr Glu Leu Gln Lys Leu Leu Glu Ser Arg Gly Leu Phe Ala Arg 
    770                 775                 780                 


Leu Leu Ala Val Asp Val Ala Tyr His Ser His His Met Glu Leu Val 
785                 790                 795                 800 


Gly Glu Glu Tyr Ala Lys Ala Ile Ala Gly Ile Lys Thr Arg Asn Gly 
                805                 810                 815     


Asn Ala Leu Lys Phe Tyr Ser Ser Val Tyr Gly Arg Glu Leu Gly Ala 
            820                 825                 830         


Glu Glu Val Gly Pro Ser Tyr Trp Val Lys Asn Leu Leu Cys Gln Val 
        835                 840                 845             


Lys Phe Ser Glu Ala Met Arg Gln Leu Cys Leu Ala Pro Ala Ile Gln 
    850                 855                 860                 


Ser Arg Arg Lys Asn Ala Lys Arg His Asn Ile Asp Phe Leu Val Glu 
865                 870                 875                 880 


Ile Gly Pro His Ser Ala Leu Ala Gly Pro Ile Arg Glu Ile Ile Gln 
                885                 890                 895     


Ser Asp Pro Lys Leu Lys Ile Ala Glu Val Met Tyr Ala Ser Ala Leu 
            900                 905                 910         


Ile Arg Lys Val Glu Gly Ile Arg Thr Val Leu Asp Leu Ala Gly Lys 
        915                 920                 925             


Leu Ser Ala Ile Gly Tyr Asn Val Asn Tyr Ala Ala Leu Asn Arg Pro 
    930                 935                 940                 


Ser Ala Asp His Gln Gly Thr Leu Leu Val Asp Leu Pro Ser Tyr Thr 
945                 950                 955                 960 


Trp Asn His Ser Ser Ser Tyr Trp Ala Glu Pro Arg Arg Ser Arg Ala 
                965                 970                 975     


Trp Arg Gln Arg Leu Phe Pro Lys Val Asp Ile Leu Gly Leu Lys Asp 
            980                 985                 990         


Glu Asn Ser Glu Pro Leu Gln Leu  Ser Trp Arg Asn His  Leu Arg Ser 
        995                 1000                 1005             


Ser Asp  Val Pro Trp Leu Leu  Gln His Lys Ile Gln  Ser Thr Met 
    1010                 1015                 1020             


Val Phe  Pro Ala Ala Gly Phe  Ile Ala Met Ala Ile  Glu Ala Gly 
    1025                 1030                 1035             


Ala Gln  Arg Ser Lys Asp Arg  Phe Ala Lys Lys Ile  Ser Ala Phe 
    1040                 1045                 1050             


Gln Leu  Arg Glu Val Asn Ile  Gly Ser Ala Leu Val  Leu Pro Glu 
    1055                 1060                 1065             


Gln Asp  Thr Leu Asp Thr Ile  Leu Thr Leu Arg Pro  Ile Arg Asp 
    1070                 1075                 1080             


Ser Ser  Lys Lys His Ser Glu  Thr Tyr Thr Glu Phe  His Ile Tyr 
    1085                 1090                 1095             


Ser Val  Thr Asn Asp Asn His  Trp Thr Glu His Cys  His Gly Leu 
    1100                 1105                 1110             


Ile Tyr  Leu Gln His Gln Lys  Gln Gln Glu Thr Thr  Arg Glu Thr 
    1115                 1120                 1125             


His Leu  Ser Leu Gln Pro Ala  Val Asp Glu Phe Arg  Thr Thr Leu 
    1130                 1135                 1140             


Pro Val  Pro Asp Phe Tyr Asp  His Leu Ser Ser Ile  Gly Leu Glu 
    1145                 1150                 1155             


Tyr Gly  Glu Val Phe Gln Asn  Leu Leu Glu Ala Arg  Ser Ser Pro 
    1160                 1165                 1170             


Asp Lys  Leu Thr Gly Val Leu  Lys Leu Pro Ala Thr  Ala Thr Ala 
    1175                 1180                 1185             


Met Pro  Leu Asp Gln Asp His  Thr Tyr Val Ile His  Pro Ala Thr 
    1190                 1195                 1200             


Leu Asp  Ala Ile Leu His Thr  Leu Phe Gly Ala Val  Ser Ala Glu 
    1205                 1210                 1215             


Asn Trp  Leu Asn Asp Thr Ala  Ile Pro Val Phe Val  Ser Asn Leu 
    1220                 1225                 1230             


Trp Ile  Ser Ala Glu Leu Pro  Phe Gln Gly Gly His  Val Leu Arg 
    1235                 1240                 1245             


Gly Asn  Ala Leu Ile Ser Ala  Arg Asp Asn Gln Ser  Leu Lys Ser 
    1250                 1255                 1260             


Asp Leu  Val Val Ile Asp Asp  Thr Lys Asn Ala Pro  Val Val Gln 
    1265                 1270                 1275             


Phe Thr  Glu Leu Glu Trp Arg  Phe Val Pro Arg Pro  Ile Glu Asn 
    1280                 1285                 1290             


Asp Asp  Ile Gly Asp Asn His  His Leu Gly Tyr Thr  Val Asp Trp 
    1295                 1300                 1305             


Glu Ala  Asp Leu Asp Phe Val  Asp Leu Lys Asn Thr  Asn Gln Met 
    1310                 1315                 1320             


Pro His  Ser Ala Gly Asp Tyr  Leu Lys Ile Leu Ala  Phe Arg Asn 
    1325                 1330                 1335             


Pro Glu  Val Ser Val Leu Asp  Val Ser Ala Ser Thr  Ser Ser Ile 
    1340                 1345                 1350             


Ile Thr  Phe Leu Lys Ala Leu  Asp Ile Ala Gln Thr  Gly Ala Arg 
    1355                 1360                 1365             


Asn Arg  Cys Arg Ala Tyr Thr  Val Ala His Pro Gln  Arg Asn Arg 
    1370                 1375                 1380             


Ala Gly  Leu Val Ser Glu Leu  Pro Glu Val Pro Tyr  Asp Val Leu 
    1385                 1390                 1395             


Ser Lys  Lys Ala Leu Asp Ile  Glu Leu Gly Pro Asn  Thr Pro Asp 
    1400                 1405                 1410             


Phe Glu  Leu Lys Ser Phe Asp  Val Ile Ile Val Thr  Gly Ser Leu 
    1415                 1420                 1425             


Ala Glu  Phe Asn Gln Pro His  Arg Ala Leu Gly His  Ile Arg Ser 
    1430                 1435                 1440             


Leu Leu  Lys Pro Asp Gly Lys  Leu Ile Val Leu His  Glu Gly Thr 
    1445                 1450                 1455             


Ile Asp  Asn Asp Pro Leu Phe  Leu Gln Trp Arg Thr  Ser Leu Gln 
    1460                 1465                 1470             


Gln Ala  Gly Phe Leu Asp His  Lys Leu Leu Glu Ser  Asp Asp Ser 
    1475                 1480                 1485             


Gly Asp  Arg Leu Asp Asn Gly  Ser Ile Phe Leu Ala  His Pro Asn 
    1490                 1495                 1500             


Gln Asp  Thr Gln Pro Gly Thr  Pro Glu Val Ile Val  Met Gly Glu 
    1505                 1510                 1515             


Asp His  Asn Gln Thr Val Glu  Ser Ser His Leu Ala  Thr Ile Leu 
    1520                 1525                 1530             


Ala Leu  Glu Pro Gly Gln Ile  Asp Gln Thr Ser Leu  Tyr Glu Val 
    1535                 1540                 1545             


Ala Pro  Thr Asp Lys Val Leu  Ile Val Trp Asp Ala  Thr Ala Glu 
    1550                 1555                 1560             


Val Leu  Ser Thr Pro Thr Ile  Glu Gln Phe Asp Ala  Ile Lys Arg 
    1565                 1570                 1575             


Val Phe  Ser Gln Thr Gln Arg  Leu Leu Trp Val Thr  Thr Gly Lys 
    1580                 1585                 1590             


Ala Asn  Ala Thr Lys Arg Pro  Asp Ser Asn Ile Val  Thr Gly Leu 
    1595                 1600                 1605             


Ala Arg  Thr Ala Arg Thr Glu  Asn Gly Gly Ala Arg  Leu Val Thr 
    1610                 1615                 1620             


Leu Asp  Leu Asp Glu Glu Glu  Lys Leu Ser Arg Gln  Asp Gly Thr 
    1625                 1630                 1635             


Gln Ile  Ile Ser Ala Val Leu  Arg Arg Thr Phe Met  Gly Asn Glu 
    1640                 1645                 1650             


Asn Gln  His Met Gly Glu Thr  Glu Tyr Val Glu Arg  Lys Gly Leu 
    1655                 1660                 1665             


Ile Thr  Ile Pro Arg Leu Ser  Val Asp Asp Ser Met  Asn Gln Ala 
    1670                 1675                 1680             


Ile Glu  Ser Tyr Ile Asn Pro  Ser Gly Lys Asp Leu  Gln Leu Val 
    1685                 1690                 1695             


His His  Lys Gly Val Val Phe  Ser Leu Val Asp Arg  Thr Asp Ser 
    1700                 1705                 1710             


Arg Lys  Pro Phe Ser Phe Gln  Glu Val Ala Tyr Glu  Asp Glu Leu 
    1715                 1720                 1725             


Glu Glu  Asn Glu Ile Arg Ile  Glu Val Arg Ala Met  Thr Leu Val 
    1730                 1735                 1740             


Ser Gly  Gln Arg Val Asn Leu  Leu Thr Gln Asp Ile  Ser Gly Val 
    1745                 1750                 1755             


Val Ile  Lys Val Gly Glu Gln  Val Thr Gly Leu Leu  Pro Gly Asp 
    1760                 1765                 1770             


Arg Val  Phe Gly Ser Val Ser  Asn Lys Val Ser Asn  Thr Tyr Arg 
    1775                 1780                 1785             


Ala Lys  Ala Ser Ala Phe Gln  Lys Ile Pro Asp Gly  Val Pro Phe 
    1790                 1795                 1800             


Glu Ile  Ala Ala Ser Tyr Pro  Thr Ala Tyr Ser Thr  Ala Phe Tyr 
    1805                 1810                 1815             


Ala Met  Phe Arg Val Ala His  Val Thr Arg Ala Asp  Asn Val Phe 
    1820                 1825                 1830             


Val Ser  Ser Ala Ala Thr Pro  Val Gly Arg Ala Leu  Ile Asp Leu 
    1835                 1840                 1845             


Cys Gly  Lys Leu Gly Ala Lys  Val Tyr Val Gly Val  Ser Thr Asp 
    1850                 1855                 1860             


Lys Glu  Ala Phe Phe Met Glu  Thr Gly Leu His Phe  Pro Lys Asp 
    1865                 1870                 1875             


Asn Ile  Ile Tyr Asn Asn Asp  Glu Arg Ser Leu Ala  Gly Leu Leu 
    1880                 1885                 1890             


Ala Asn  Thr Asn Gly His Gly  Met Asp Val Ile Phe  Asn Ser Leu 
    1895                 1900                 1905             


Ala Gly  Glu Ile Leu Gln Thr  Cys Trp Asn Cys Ile  Ala Pro Phe 
    1910                 1915                 1920             


Gly Arg  Phe Ile Glu Leu Gly  Thr Gln Asp Val Ile  Asp Asn Ser 
    1925                 1930                 1935             


Arg Leu  Asp Met Ala Asn Phe  Arg Arg Asn Thr Ser  Phe Thr Ala 
    1940                 1945                 1950             


Leu Asn  Leu Ser Arg Leu Gln  Asp Glu Arg Pro Ala  Val Gly Asp 
    1955                 1960                 1965             


Glu Met  Trp Gly Gln Thr Val  Glu Leu Val Ser Lys  Asp Thr Phe 
    1970                 1975                 1980             


Ser Ser  Thr Val Pro Asn Leu  Gln Val Phe Asn Gly  Glu Gly Ile 
    1985                 1990                 1995             


Ser Gln  Ala Phe Glu Arg Leu  Met Glu Glu Glu Asn  Thr Asp His 
    2000                 2005                 2010             


Val Val  Leu Thr Phe Gln Pro  Thr Glu Arg Met Val  Val Ile Pro 
    2015                 2020                 2025             


Thr Ser  Thr Arg Asp Gln Leu  Phe Arg Ala Glu Ala  Thr Tyr Leu 
    2030                 2035                 2040             


Leu Val  Gly Gly Leu Gly Gly  Ile Gly Arg Ala Thr  Ala Ser Trp 
    2045                 2050                 2055             


Met Val  Asp His Gly Ala Arg  Asn Leu Ile Phe Ala  Asn Arg Ser 
    2060                 2065                 2070             


Gly Ile  Ser Lys Gln Glu Ala  Lys Gly Thr Ile His  Ala Leu Arg 
    2075                 2080                 2085             


Ser Leu  Gly Gly Arg Ile His  Leu Gln Lys Cys Asp  Val Ser Asp 
    2090                 2095                 2100             


Ala Glu  His Val Lys Gln Leu  Ile Glu Asp Cys Ala  Ser Gln Leu 
    2105                 2110                 2115             


Pro Pro  Ile Arg Gly Val Ile  Gln Gly Ala Met Met  Val Gln Asp 
    2120                 2125                 2130             


Leu Ile  Val Asp Arg Met Thr  Val Asp Glu Trp Gln  Ala Ile Val 
    2135                 2140                 2145             


Arg Pro  Lys Val His Gly Thr  Phe Asn Leu His Gln  His Leu Pro 
    2150                 2155                 2160             


Lys Asp  Met Asp Tyr Phe Ile  Ile Leu Ser Ser Val  Ser Gly Val 
    2165                 2170                 2175             


Val Gly  Gln Thr Thr Gln Ala  Ala Tyr Gly Ala Gly  Asn Thr Phe 
    2180                 2185                 2190             


Leu Glu  Ala Phe Ser Gly Phe  Arg Gln Ala Gln Gly  Leu Pro Ala 
    2195                 2200                 2205             


Leu Ser  Leu Asp Leu Gly Ala  Ile Ser Gly Val Gly  Trp Val Ala 
    2210                 2215                 2220             


Thr Asp  Glu Asn Lys Gln Val  Ser Arg Ser Leu Gln  Asp Gln Gly 
    2225                 2230                 2235             


Phe Ser  Leu Thr Gly Glu Lys  Leu Val Leu Ala Ile  Ile Arg Ser 
    2240                 2245                 2250             


Ala Ile  Leu Glu Pro Phe Gly  Arg Gly Gly Lys Thr  Gln Thr Ile 
    2255                 2260                 2265             


Thr Gly  Leu Gly Ser Tyr Lys  Thr Gly Arg Ser Leu  Thr Ala Leu 
    2270                 2275                 2280             


Asp Asn  Ser Met Phe Ser His  Tyr Arg Lys His Ser  Lys Glu Ala 
    2285                 2290                 2295             


Glu Ile  Leu Gly Glu Lys Glu  Gln Thr Ser Asn Gly  Lys Leu Ser 
    2300                 2305                 2310             


Ile Arg  Asp Ala Leu Lys Thr  Ser Asp Ser Leu Glu  Asp Ala Ala 
    2315                 2320                 2325             


Ala Ile  Ile Cys Gln Ala Leu  Val Gly Tyr Leu Ala  Ser Arg Ser 
    2330                 2335                 2340             


Ala Leu  Ser Leu Asp Asn Phe  Ser Thr Glu Met Ser  Leu Ser Asp 
    2345                 2350                 2355             


Cys Gly  Val Asp Ser Ile Val  Ala Val Asp Val Arg  Asn Trp Ile 
    2360                 2365                 2370             


Ala Arg  Asp Leu Glu Ser Ser  Ile Pro Leu Val Glu  Leu Leu Gly 
    2375                 2380                 2385             


Asn His  Pro Leu Ser Gln Leu  Ser Val Glu Ile Ala  Ser Lys Ser 
    2390                 2395                 2400             


Lys Val  Ile Pro Leu Glu Ile  Lys Ser Arg Gly Ala  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ser  Ala 
    2420     


<210>  255
<211>  770
<212>  DNA
<213>  Bipolaris maydis

<400>  255
atgtttttca aactcgcaat tctgtctact ctctctgctt tccaagctgc agctttggta       60

acggacaggt ccggtaatga ccagaggcct cttaaacctg aagcggctac cactaagaat      120

caacctttcc aactcttggt tgacgatggc ttctacttcg gcaatccaag tacggattgc      180

aagcattcct cgcagcctta catttatcaa cagtatactc gtttcacgga cgactatacc      240

tacctttcga caatgctagc accagatgtt gatttcacag tcgtcggtca tcatgcgctt      300

tcgggccact atcacgactt caaacatttc tatgtcaatg ccttttacag acttggtagc      360

tgcattacag aagtttatcc tgagcttttc aaacttactt tgttgactat ccacggagga      420

tgcaatgaag agtggagcgt acaagagata cgaggtcaag gacgagcaaa caatggtgag      480

ttggatattt gccgttgtta tctctttaac tgtattgtcg ctaacatcca agtctaaaag      540

gccgcgattt cgatattatt aacgtgtggg tcacgaagtg gcataatggc cgaattgtaa      600

aggtccgcac gtacattgat gctgttgaga gcatgatcat gctcaaggaa aatgaggtct      660

ggacgaactc ctctaccgaa actgaacata caaacttcct gcctggtcca agaggaatgc      720

cagatatggc tgctcttgga gagttcttag caaagggtgg acactactaa                 770


<210>  256
<211>  214
<212>  PRT
<213>  Bipolaris maydis

<400>  256

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Asp Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Tyr Ile 
        35                  40                  45              


Tyr Gln Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Thr Tyr Leu Ser Thr 
    50                  55                  60                  


Met Leu Ala Pro Asp Val Asp Phe Thr Val Val Gly His His Ala Leu 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Leu Gly Ser Cys Ile Thr Glu Val Tyr Pro Glu Leu Phe Lys Leu 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Glu Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Ile Arg Gly Gln Gly Arg Ala Asn Asn Gly Arg Asp Phe Asp Ile 
    130                 135                 140                 


Ile Asn Val Trp Val Thr Lys Trp His Asn Gly Arg Ile Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Ile Asp Ala Val Glu Ser Met Ile Met Leu Lys Glu Asn 
                165                 170                 175     


Glu Val Trp Thr Asn Ser Ser Thr Glu Thr Glu His Thr Asn Phe Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Ala Lys Gly Gly His Tyr 
    210                 


<210>  257
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  257

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Asp Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Phe Ile 
        35                  40                  45              


Tyr Gln Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Thr Tyr Leu Ser Thr 
    50                  55                  60                  


Met Leu Ala Pro Asp Val Asp Phe Thr Val Val Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Leu Gly Ser Cys Ile Ser Glu Val Tyr Pro Glu Leu Phe Arg Ile 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Asp Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Met Arg Gly Gln Gly Arg Ala Asn Asn Gly Arg Asp Phe Asp Ile 
    130                 135                 140                 


Ile Asn Val Trp Val Thr Arg Trp His Gln Gly Arg Met Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Ile Asp Ala Val Glu Ser Met Ile Met Leu Lys Glu Asn 
                165                 170                 175     


Glu Val Trp Thr Asn Ser Ser Ser Glu Thr Glu His Thr Asn Phe Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Ala Lys Gly Gly His Tyr 
    210                 


<210>  258
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  258

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Asp Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Tyr Ile 
        35                  40                  45              


Tyr Gln Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Thr 
    50                  55                  60                  


Met Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Leu Gly Ser Cys Ile Thr Glu Val Tyr Pro Asp Leu Phe Lys Ile 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Asp Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Val Arg Gly Gln Gly Arg Ala Asn Asn Gly Arg Asp Phe Asp Ile 
    130                 135                 140                 


Val Asn Val Trp Val Thr Lys Trp His Asn Gly Arg Ile Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Ile Asp Ala Val Glu Ser Met Ile Met Leu Lys Glu Asn 
                165                 170                 175     


Glu Leu Trp Thr Asn Ser Thr Thr Glu Thr Glu His Thr Asn Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Ala Lys Gly Gly His Tyr 
    210                 


<210>  259
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  259

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Glu Gly Phe Phe 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Tyr Ile 
        35                  40                  45              


Tyr Gln Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Thr 
    50                  55                  60                  


Met Leu Ala Pro Asp Val Asp Phe Thr Val Val Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Leu Gly Ser Cys Ile Ser Asp Val Tyr Pro Asp Leu Phe Arg Leu 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Asp Asp Trp Ser Val Gln 
        115                 120                 125             


Glu Ile Arg Gly Gln Gly Arg Ala Asn Asn Gly Arg Asp Phe Asp Ile 
    130                 135                 140                 


Ile Asn Val Trp Val Thr Lys Trp His Asn Gly Arg Ile Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Ile Asp Ala Val Glu Ser Met Met Met Leu Lys Glu Asn 
                165                 170                 175     


Glu Val Trp Thr Asn Ser Thr Thr Glu Thr Glu His Ser Asn Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Asp Phe Leu 
        195                 200                 205             


Ala Lys Gly Gly His Tyr 
    210                 


<210>  260
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  260

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Asp Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Trp Ile 
        35                  40                  45              


Trp Gln Gln Tyr Thr Arg Phe Ser Asp Asp Tyr Ser Tyr Leu Ser Thr 
    50                  55                  60                  


Met Ile Ala Pro Asp Val Asp Phe Thr Val Met Gly His His Ala Leu 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Val Ala Ser Cys Ile Thr Glu Val Tyr Pro Asp Leu Phe Lys Val 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Asp Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Ile Arg Gly Gln Gly Arg Ala Asn Asn Gly Lys Asp Phe Asp Ile 
    130                 135                 140                 


Ile Asn Val Trp Val Thr Lys Trp His Asn Gly Arg Ile Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Ile Asp Ala Val Glu Ser Met Ile Met Leu Lys Glu Asn 
                165                 170                 175     


Glu Ile Trp Thr Asn Ser Ser Thr Glu Thr Asp His Thr Asn Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Ala Lys Gly Gly His Tyr 
    210                 


<210>  261
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  261

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Glu Gly Phe Phe 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Trp Ile 
        35                  40                  45              


Trp Gln Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Thr 
    50                  55                  60                  


Leu Val Ala Pro Asp Val Asp Phe Thr Val Val Gly His His Ala Leu 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Val Gly Ser Cys Ile Ser Glu Val Tyr Pro Glu Leu Phe Arg Leu 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Glu Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Met Arg Gly Gln Gly Arg Ala Asn Asn Gly Lys Asp Phe Asp Ile 
    130                 135                 140                 


Val Asn Val Trp Val Thr Arg Phe His Asn Gly Arg Met Val Lys Ile 
145                 150                 155                 160 


Arg Thr Tyr Ile Asp Ala Val Glu Ser Met Ile Met Leu Arg Glu Asn 
                165                 170                 175     


Glu Leu Trp Thr Asn Ser Thr Thr Glu Thr Glu His Thr Asn Trp Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Gly Lys Gly Gly His Tyr 
    210                 


<210>  262
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  262

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Glu Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Phe Ile 
        35                  40                  45              


Trp Asn Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Thr 
    50                  55                  60                  


Leu Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His His Ala Leu 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Phe Val Asn Ala Phe Trp 
                85                  90                  95      


Arg Leu Gly Ser Cys Leu Thr Glu Val Tyr Pro Glu Leu Phe Lys Ile 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Glu Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Met Arg Gly Asn Gly Arg Ala Asn Asn Gly Lys Asp Phe Asp Ile 
    130                 135                 140                 


Val Asn Val Trp Val Thr Lys Trp His Asn Gly Arg Ile Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Val Asp Ala Val Glu Ser Met Ile Val Ile Arg Glu Asn 
                165                 170                 175     


Glu Ile Trp Thr Asn Ser Thr Thr Glu Thr Glu His Thr Asn Phe Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Gly Lys Gly Gly His Tyr 
    210                 


<210>  263
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  263

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Glu Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Arg His Ser Ser Gln Pro Trp Ile 
        35                  40                  45              


Tyr Asn Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Thr Tyr Leu Ser Thr 
    50                  55                  60                  


Met Ile Ala Pro Asp Val Asp Trp Thr Val Met Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Val Ala Ser Cys Ile Ser Asp Val Tyr Pro Asp Leu Phe Lys Val 
            100                 105                 110         


Thr Val Leu Thr Ile His Gly Gly Cys Asn Glu Asp Trp Ser Val Gln 
        115                 120                 125             


Glu Met Arg Gly Gln Gly Arg Ala Asn Asn Gly Lys Asp Phe Asp Leu 
    130                 135                 140                 


Val Asn Val Trp Val Ser Arg Trp His Asn Gly Arg Met Val Lys Ile 
145                 150                 155                 160 


Arg Thr Tyr Val Asp Ala Val Glu Ser Met Met Ile Leu Lys Glu Asn 
                165                 170                 175     


Glu Ile Trp Thr Asn Ser Ser Ser Glu Thr Asp His Thr Gln Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Asp Phe Leu 
        195                 200                 205             


Ala Lys Gly Gly His Tyr 
    210                 


<210>  264
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  264

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Glu Gly Phe Tyr 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Tyr Ile 
        35                  40                  45              


Trp Asn Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Thr 
    50                  55                  60                  


Met Ile Ala Pro Asp Val Asp Phe Thr Val Met Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Phe Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Leu Ala Ser Cys Ile Ser Asp Val Tyr Pro Asp Leu Phe Arg Ile 
            100                 105                 110         


Thr Leu Val Thr Ile His Gly Gly Cys Gln Asp Asp Trp Ser Val Gln 
        115                 120                 125             


Glu Val Arg Gly Asn Ala Arg Ala Asn Asn Gly Arg Asp Phe Asp Ile 
    130                 135                 140                 


Val Asn Leu Trp Val Thr Arg Phe His Gln Gly Arg Met Val Lys Val 
145                 150                 155                 160 


Arg Thr Tyr Val Asp Ala Val Glu Ser Met Ile Ile Leu Lys Glu Asn 
                165                 170                 175     


Glu Leu Trp Thr Asn Ser Thr Thr Glu Thr Glu His Thr Asn Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Met Pro Asp Met Ala Ala Leu Gly Glu Phe Leu 
        195                 200                 205             


Gly Lys Gly Gly His Tyr 
    210                 


<210>  265
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  265

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Glu Asp Glu Gly Phe Phe 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Trp Ile 
        35                  40                  45              


Tyr Asn Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Ser 
    50                  55                  60                  


Leu Ile Ala Pro Asp Val Asp Trp Thr Val Met Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Val Gly Ser Cys Leu Ser Asp Val Tyr Pro Asp Leu Phe Arg Val 
            100                 105                 110         


Thr Val Leu Thr Ile His Gly Gly Cys Gln Asp Glu Trp Ser Val Gln 
        115                 120                 125             


Glu Val Arg Gly Gln Gly Arg Ala Asn Asn Gly Lys Asp Phe Glu Ile 
    130                 135                 140                 


Val Asn Val Trp Ile Ser Arg Phe His Asn Gly Arg Met Val Lys Ile 
145                 150                 155                 160 


Arg Thr Tyr Val Asp Ala Met Glu Ser Met Met Leu Leu Lys Asp Asn 
                165                 170                 175     


Glu Ile Trp Thr Asn Ser Ser Thr Glu Thr Glu His Thr Gln Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Leu Pro Asp Met Ala Ala Leu Gly Asp Phe Leu 
        195                 200                 205             


Gly Lys Gly Gly His Tyr 
    210                 


<210>  266
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 256

<400>  266

Met Phe Phe Lys Leu Ala Ile Leu Ser Thr Leu Ser Ala Phe Gln Ala 
1               5                   10                  15      


Ala Ala Leu Asn Gln Pro Phe Gln Leu Leu Val Asp Glu Gly Phe Phe 
            20                  25                  30          


Phe Gly Asn Pro Ser Thr Asp Cys Lys His Ser Ser Gln Pro Tyr Ile 
        35                  40                  45              


Trp Asn Gln Tyr Thr Arg Phe Thr Asp Asp Tyr Ser Tyr Leu Ser Ser 
    50                  55                  60                  


Leu Val Ala Pro Asp Val Asp Trp Thr Val Met Gly His His Ala Ile 
65                  70                  75                  80  


Ser Gly His Tyr His Asp Phe Lys His Phe Tyr Val Asn Ala Phe Tyr 
                85                  90                  95      


Arg Val Gly Ser Cys Leu Ser Asp Val Tyr Pro Asp Leu Phe Arg Ile 
            100                 105                 110         


Thr Leu Leu Thr Ile His Gly Gly Cys Asn Asp Asp Trp Ser Val Gln 
        115                 120                 125             


Glu Met Arg Gly Asn Gly Arg Ala Asn Asn Gly Lys Asp Phe Glu Val 
    130                 135                 140                 


Ile Asn Leu Trp Val Thr Arg Trp His Gln Gly Arg Met Val Lys Ile 
145                 150                 155                 160 


Arg Thr Tyr Val Asp Ala Met Glu Ser Met Met Val Ile Arg Glu Asn 
                165                 170                 175     


Glu Ile Trp Thr Asn Ser Thr Thr Glu Thr Glu His Thr Gln Tyr Leu 
            180                 185                 190         


Pro Gly Pro Arg Gly Leu Pro Asp Met Ala Ala Leu Gly Asp Phe Leu 
        195                 200                 205             


Gly Lys Gly Gly His Tyr 
    210                 


<210>  267
<211>  1416
<212>  DNA
<213>  Bipolaris maydis

<400>  267
atgtctaacg gcttcctttt cgtgagagac tcccgcacta ctcaagaata tagagtccca       60

atacagcgaa atgcaatcct tgcgacggca ttcaaagata tcaaggcccc ttcgtctagc      120

gggaatagag cagacaaatt agacagcggt ttgagagtgc atgaccccgg gctcctgaat      180

acgacagtgg tggaaacagg tgtgagtttt gcgtaataca aatttccaca cccctctcat      240

catccaggtg ctaagaggat ctagagatgg agaaagagat ctacttcttt tcagaggtta      300

cagtctagaa caactatggc aaagtgacta tgaagatatg ttacatttgc tggtgtgggc      360

aaaataccca acacctgtgc agaaggaatc tttacgcaga gcattgatag cggctatgct      420

agaggtcccc aaaaccgttt tcgaagtagt gtcggccttc ccgtaagtat tgagcatgtt      480

gtttcccata atggagaaac taatatgttc aaaggtcggc gtcccctccc atgccgatgg      540

tcgtggctgg tttggcggcg tatcttggaa gtaatcccga tatgattcca gcgtcaaacg      600

gcggaaacat ctaccaaggt gacatcgaaa aaactgacaa agcaattgtc aagacgatcg      660

ctgcatacgc agttgtcgta gggatggcgg cctgtcatcg gaaaggaatt gagttcacag      720

ctcctttgtt ggattacaat ttcatcgaaa acctgttcca catgtccggc atggttgacg      780

atctaactgg gcgaccagat gcgatgaaag tgtcatgctt tcggcggttt gcagcattga      840

atatggacca cgggatggca ttggctgtat tctccacaat ggtcacagca tcgtcactca      900

cagatcccat atcttgtctt gttgcttcat tagcagcggc atatggtcct ctacatttcg      960

gtgcgactga ggctgcgcat ctcaaccttc gtagtatcgg agacaaatca aaagtccccg     1020

aatttatctc ggaggtgaag caaggcaagc gaaaactatt tggatatgga caccgcactt     1080

acaaaggcac cgatccacgt gtaaggccta taaaggagct cattgaagat tcgggtgcaa     1140

actcagatcc gttgattgag attgcaaggg aagttgaaag actcgcttct aacgacgact     1200

atttcacatc aagaggcctt catccgaatg ctgatttcta tgggaatttt gttttcactg     1260

ccgtgtaagt tgcccgacga tttatgtaat agtccgctaa cattactttc aagtggtttt     1320

cagtccgatt tcattcctat agctatgatt tctcaacggc tcattggaat aatggcgcac     1380

tggcgtgagg cgatgggtga gtctagcgat acttag                               1416


<210>  268
<211>  420
<212>  PRT
<213>  Bipolaris maydis

<400>  268

Met Ser Asn Gly Phe Leu Phe Val Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Ile Leu Ala Thr Ala Phe Lys 
            20                  25                  30          


Asp Ile Lys Ala Pro Ser Ser Ser Gly Asn Arg Ala Asp Lys Leu Asp 
        35                  40                  45              


Ser Gly Leu Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Gly Val Ser Phe Ala Asp Gly Glu Arg Asp Leu Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Ala Lys Tyr Pro Thr Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Arg Arg Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Val Phe Glu Val Val Ser Ala Phe Pro Ser Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Val Val Ala Gly Leu Ala Ala Tyr Leu Gly Ser Asn Pro Asp Met 
145                 150                 155                 160 


Ile Pro Ala Ser Asn Gly Gly Asn Ile Tyr Gln Gly Asp Ile Glu Lys 
                165                 170                 175     


Thr Asp Lys Ala Ile Val Lys Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Ala Ala Cys His Arg Lys Gly Ile Glu Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Asp Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Met Val 
    210                 215                 220                 


Asp Asp Leu Thr Gly Arg Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Phe Ile Ser Glu Val Lys Gln Gly Lys Arg Lys Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Glu Leu Ile Glu Asp Ser Gly Ala Asn Ser Asp Pro Leu Ile Glu 
            340                 345                 350         


Ile Ala Arg Glu Val Glu Arg Leu Ala Ser Asn Asp Asp Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Ser Asp Phe Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Ile Gly Ile Met Ala His Trp Arg Glu Ala Met Gly Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  269
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  269

Met Ser Asn Gly Phe Leu Phe Val Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Val Leu Ala Thr Ala Phe Arg 
            20                  25                  30          


Asp Ile Lys Ala Pro Ser Ser Ser Gly Asn Arg Ala Asp Lys Leu Asp 
        35                  40                  45              


Ser Gly Leu Arg Val His Asp Pro Gly Leu Val Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Gly Val Ser Phe Ala Asp Gly Glu Arg Asp Ile Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Ala Lys Tyr Pro Thr Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Arg Arg Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Val Phe Glu Val Val Ser Ala Phe Pro Ser Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Val Val Ala Ala Leu Ala Ala Tyr Leu Gly Ser Asn Pro Asp Met 
145                 150                 155                 160 


Val Pro Ala Ser Asn Gly Gly Asn Ile Tyr Gln Gly Asp Ile Glu Lys 
                165                 170                 175     


Thr Asp Arg Ala Ile Val Lys Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Ala Ala Cys His Arg Lys Gly Ile Glu Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Asp Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Met Leu 
    210                 215                 220                 


Asp Asp Leu Thr Gly Lys Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Lys Phe Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Val Ala Glu Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Phe Ile Ser Glu Val Lys Gln Gly Lys Lys Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Glu Met Ile Glu Asp Ser Gly Gly Gln Ser Asp Pro Leu Ile Glu 
            340                 345                 350         


Val Ala Arg Glu Val Glu Lys Leu Ala Ser Asn Asp Asp Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Ser Asp Tyr Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Ile Gly Ile Met Ala His Trp Arg Glu Ala Met Gly Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  270
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  270

Met Ser Asn Gly Phe Leu Phe Val Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Ile Leu Ala Thr Ala Phe Lys 
            20                  25                  30          


Glu Ile Lys Ala Pro Thr Ser Ser Gly Asn Arg Ala Asp Lys Leu Asp 
        35                  40                  45              


Ser Gly Leu Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Ile 
    50                  55                  60                  


Glu Thr Gly Val Ser Tyr Ala Asp Gly Glu Arg Asp Leu Leu Val Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Phe Ala Lys Tyr Pro Thr Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Arg Arg Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Val Phe Asp Val Val Ser Ala Phe Pro Ser Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Ile Val Val Ala Gly Leu Gly Ala Tyr Leu Gly Ser Asn Pro Asp Met 
145                 150                 155                 160 


Ile Pro Ala Ser Asn Gly Gly Asn Val Tyr Gln Gly Asp Ile Glu Lys 
                165                 170                 175     


Ser Asp Lys Ala Ile Val Lys Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Ala Ala Cys His Arg Lys Gly Ile Glu Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Glu Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Leu Val 
    210                 215                 220                 


Asp Asp Leu Thr Gly Arg Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Phe Ile Ser Glu Leu Lys Gln Gly Lys Lys Lys Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Asp Leu Ile Glu Asp Ser Gly Ala Asn Ser Asp Pro Leu Val Asp 
            340                 345                 350         


Met Ala Arg Glu Val Glu Arg Leu Ala Ser Asn Asp Asp Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Ser Asp Phe Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Val Gly Ile Met Ala His Trp Arg Glu Ala Met Gly Asp 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  271
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  271

Met Ser Asn Ala Phe Leu Phe Val Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Val Leu Ala Thr Ala Phe Lys 
            20                  25                  30          


Asp Ile Arg Ala Pro Ser Ser Ser Gly Asn Arg Ala Glu Lys Leu Asp 
        35                  40                  45              


Thr Gly Leu Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Gly Val Ser Tyr Ala Asp Gly Glu Arg Asp Val Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Ile His Leu Leu Val Trp Ala Lys Tyr Pro Ser Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Arg Lys Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Ile Phe Glu Met Val Ser Gly Phe Pro Ser Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Val Val Ala Ala Leu Ala Gly Tyr Leu Gly Ser Asn Pro Asp Met 
145                 150                 155                 160 


Ile Pro Ala Ser Asn Gly Ala Asn Leu Tyr Gln Gly Asp Ile Asp Lys 
                165                 170                 175     


Thr Asp Lys Ala Ile Ile Lys Thr Ile Ala Ala Phe Ala Val Val Val 
            180                 185                 190         


Gly Met Ala Ala Cys His Lys Lys Gly Ile Glu Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Asp Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Met Val 
    210                 215                 220                 


Asp Asp Leu Thr Gly Lys Pro Asp Ala Val Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Phe Ile Ser Glu Val Lys Gln Gly Lys Arg Lys Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Glu Leu Ile Asp Glu Ser Gly Ala Asn Ser Asp Pro Leu Leu Glu 
            340                 345                 350         


Ile Ala Arg Glu Val Glu Arg Val Ala Ser Asn Asp Glu Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Ser Ala Val Gly Phe Gln Ser Asp Phe Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Ile Ile Gly Ile Met Ala His Trp Arg Glu Ala Met Gly Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  272
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  272

Met Ser Gln Gly Phe Leu Phe Ile Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Ile Leu Ala Thr Ala Phe Lys 
            20                  25                  30          


Asp Leu Arg Ala Pro Ser Ser Ser Gly Asn Arg Ala Asp Lys Leu Asp 
        35                  40                  45              


Ser Gly Met Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Ala Val Ser Phe Ala Asp Gly Glu Arg Asp Leu Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Thr Asp Tyr Glu Asp Met 
                85                  90                  95      


Val His Leu Leu Val Trp Ala Lys Tyr Pro Thr Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Arg Arg Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Leu Tyr Glu Val Val Ser Ala Phe Pro Ser Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Val Val Val Ala Gly Leu Ala Ala Tyr Leu Gly Ser Asn Pro Glu Met 
145                 150                 155                 160 


Ile Pro Ala Ser Asn Gly Gly Asn Ile Tyr Gln Gly Asp Ile Glu Lys 
                165                 170                 175     


Thr Asp Lys Ala Ile Val Lys Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Gly Ala Cys His Arg Arg Gly Ile Glu Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Glu Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Leu Leu 
    210                 215                 220                 


Asp Asp Leu Thr Gly Lys Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Leu Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Asp Phe Ile Ser Glu Val Lys Gln Ala Lys Lys Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Glu Leu Ile Glu Asp Ser Gly Ala Asn Ser Asp Pro Leu Ile Glu 
            340                 345                 350         


Met Ala Arg Glu Val Glu Lys Leu Ala Ser Asn Asp Asp Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Ser Glu Phe Ile Pro Val Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Ile Ile Gly Ile Val Ala His Trp Arg Glu Ala Met Ala Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  273
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  273

Met Ser Asn Gly Phe Leu Phe Val Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Val Leu Ala Thr Ala Phe Lys 
            20                  25                  30          


Asp Leu Lys Ala Pro Ser Ser Ser Gly Asn Arg Ala Glu Lys Val Asp 
        35                  40                  45              


Thr Gly Leu Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Gly Val Ser Phe Ala Asp Gly Asp Lys Asp Ile Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Ala Lys Tyr Pro Thr Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Lys Arg Gly Leu Met Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Leu Phe Glu Val Val Ser Gly Phe Pro Thr Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Met Val Val Ala Gly Leu Ala Ala Tyr Leu Gly Ser Asn Pro Glu Val 
145                 150                 155                 160 


Ile Pro Ala Ser Asn Gly Ala Asn Ile Tyr Gln Gly Asp Leu Glu Lys 
                165                 170                 175     


Thr Asp Arg Ala Ile Met Arg Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Ile Ala Ala Cys His Arg Lys Gly Ile Asp Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Glu Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Met Ile 
    210                 215                 220                 


Glu Glu Leu Thr Gly Arg Pro Asp Ala Leu Lys Ile Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Leu Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Phe Ile Ser Glu Val Lys Gln Gly Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Glu Leu Met Glu Glu Ser Ala Ala Asn Ser Asp Pro Leu Val Glu 
            340                 345                 350         


Ile Ala Arg Glu Val Glu Lys Ile Ala Ser Asn Asp Glu Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Thr Asp Phe Ile Pro Val Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Ile Gly Ile Met Ala His Trp Lys Glu Ala Ile Gly Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  274
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  274

Met Ser Asn Gly Phe Leu Phe Val Arg Asp Ser Arg Thr Thr Asn Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Leu Leu Ala Thr Gly Phe Arg 
            20                  25                  30          


Glu Val Arg Ala Pro Ser Ser Ser Gly Asn Arg Ala Asp Lys Val Asp 
        35                  40                  45              


Thr Gly Leu Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Gly Val Ser Phe Ala Asp Gly Glu Lys Asp Ile Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Trp Ala Lys Tyr Pro Thr Pro Val Gln Lys Asp 
            100                 105                 110         


Thr Leu Arg Arg Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Leu Phe Glu Leu Val Ser Ala Phe Pro Thr Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Leu Val Val Ala Gly Leu Ala Ala Tyr Leu Ala Ser Asn Pro Glu Ile 
145                 150                 155                 160 


Val Pro Ala Ser Asn Gly Ala Asn Ile Tyr Gln Gly Asp Ile Glu Lys 
                165                 170                 175     


Thr Asp Lys Ala Ile Val Arg Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Ala Ala Cys His Arg Lys Gly Ile Asp Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Asp Tyr Asn Phe Ile Asp Asn Leu Phe His Met Ser Gly Met Val 
    210                 215                 220                 


Asp Glu Leu Thr Gly Arg Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Leu Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Gly Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Lys Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Tyr Ile Ser Glu Val Lys Gln Ala Lys Arg Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Lys Glu Leu Ile Asp Glu Ser Ala Ala Asn Ser Asp Pro Leu Val Glu 
            340                 345                 350         


Leu Ala Arg Glu Val Glu Arg Leu Ala Ser Asn Asp Glu Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Ser Asp Phe Ile Pro Val Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Val Gly Ile Leu Ala His Trp Arg Glu Ala Met Gly Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  275
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  275

Met Ser Gln Ala Phe Leu Phe Ile Arg Asp Ser Arg Thr Thr Gln Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Val Leu Ala Thr Ala Phe Arg 
            20                  25                  30          


Glu Ile Arg Gly Pro Ser Ser Ser Gly Asn Arg Ala Glu Arg Leu Asp 
        35                  40                  45              


Ser Gly Leu Arg Ile His Asp Pro Gly Leu Met Asn Thr Ser Val Val 
    50                  55                  60                  


Asp Thr Ala Val Ser Tyr Ala Asp Gly Glu Arg Asp Val Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Val His Leu Leu Val Phe Ala Lys Tyr Pro Thr Pro Val Gln Arg Glu 
            100                 105                 110         


Ser Leu Arg Arg Ala Leu Met Ala Ala Met Leu Glu Val Pro Lys Ser 
        115                 120                 125             


Val Phe Asp Val Val Ser Gly Phe Pro Ser Gly Ser Pro Pro Met Pro 
    130                 135                 140                 


Val Val Ile Gly Gly Leu Ala Ala Tyr Leu Gly Ser Asn Pro Glu Met 
145                 150                 155                 160 


Leu Pro Ala Ser Asn Gly Ala Asn Ile Tyr Gln Gly Asp Leu Asp Lys 
                165                 170                 175     


Ser Glu Lys Ala Ile Ile Arg Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Ala Ala Cys His Arg Arg Gly Leu Asp Phe Thr Ala Pro Leu 
        195                 200                 205             


Leu Asp Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Met Leu 
    210                 215                 220                 


Asp Glu Leu Thr Gly Arg Pro Asp Gly Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Asp Tyr Ile Ser Asp Leu Lys Asn Gly Lys Lys Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Ser Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Asp Leu Ile Glu Asp Ser Gly Ala Asn Ser Asp Pro Met Val Glu 
            340                 345                 350         


Ile Ala Arg Glu Val Glu Arg Leu Ala Ser Asn Asp Glu Tyr Phe Thr 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Thr Glu Phe Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Met Leu Gly Ile Ile Ala His Trp Arg Glu Ala Leu Gly Asp 
                405                 410                 415     


Ser Thr Asp Thr 
            420 


<210>  276
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  276

Met Ser Asn Gly Phe Leu Phe Ile Arg Asp Ser Arg Thr Thr Asn Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Leu Val Ala Thr Gly Phe Arg 
            20                  25                  30          


Asp Leu Lys Ala Pro Ser Ser Ser Gly Asn Arg Ala Glu Lys Leu Asp 
        35                  40                  45              


Thr Gly Leu Arg Val His Asp Pro Gly Leu Leu Asn Thr Thr Val Val 
    50                  55                  60                  


Glu Thr Ala Val Ser Phe Ala Asp Gly Asp Arg Asp Ile Leu Leu Phe 
65                  70                  75                  80  


Arg Gly Tyr Thr Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Phe Ala Lys Tyr Pro Ser Pro Val Gln Lys Glu 
            100                 105                 110         


Ser Leu Arg Arg Ala Leu Ile Ala Ala Leu Val Glu Val Pro Lys Thr 
        115                 120                 125             


Ile Phe Glu Ile Val Ser Gly Phe Pro Ser Ala Thr Pro Pro Met Pro 
    130                 135                 140                 


Ile Val Ile Ala Gly Leu Ala Ala Tyr Leu Ala Ser Asn Pro Glu Val 
145                 150                 155                 160 


Ile Pro Ala Ser Asn Gly Ala Asn Val Tyr Gln Gly Glu Ile Glu Lys 
                165                 170                 175     


Thr Asp Lys Ala Val Met Lys Thr Ile Ala Ala Tyr Ala Leu Val Val 
            180                 185                 190         


Gly Met Gly Ala Cys His Arg Lys Gly Ile Asp Phe Ser Ala Pro Leu 
        195                 200                 205             


Leu Glu Tyr Asn Trp Ile Glu Asn Leu Phe His Met Ser Gly Met Ile 
    210                 215                 220                 


Asp Asp Leu Ser Gly Lys Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Tyr Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Gly Ala Ala Tyr Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Glu Ala Ala His Leu Asn Leu Lys Ser Val Ala Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Tyr Ile Ser Asp Met Lys Gln Ala Lys Lys Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Arg Pro Ile 
                325                 330                 335     


Lys Asp Leu Ile Glu Glu Ser Gly Ala Asn Ser Asp Pro Met Leu Glu 
            340                 345                 350         


Leu Ala Arg Glu Val Glu Arg Leu Ala Ser Gln Glu Asp Tyr Phe Ser 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Thr Glu Phe Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Ile Gly Ile Ile Ala His Trp Lys Glu Ala Met Gly Glu 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  277
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  277

Met Ser Asn Gly Phe Leu Phe Leu Arg Asp Ser Arg Thr Thr Asn Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Val Leu Ala Ser Ala Phe Arg 
            20                  25                  30          


Glu Ile Lys Gly Pro Ser Ser Ser Gly Asn Arg Ala Asp Lys Val Asp 
        35                  40                  45              


Ser Gly Leu Arg Val His Asp Pro Gly Leu Met Asn Thr Thr Val Leu 
    50                  55                  60                  


Glu Thr Ala Val Ser Tyr Ala Asp Gly Glu Lys Asp Ile Leu Val Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Glu Gln Leu Trp Gln Ser Asp Tyr Glu Asp Met 
                85                  90                  95      


Leu His Leu Leu Val Phe Ala Lys Tyr Pro Thr Pro Val Gln Lys Asp 
            100                 105                 110         


Thr Leu Lys Arg Ala Leu Ile Gly Ala Leu Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Leu Phe Glu Leu Val Ser Gly Phe Pro Thr Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Val Val Ile Gly Ala Leu Ala Ala Tyr Leu Ala Ser Asn Pro Glu Leu 
145                 150                 155                 160 


Ile Pro Ala Ser Gln Gly Ala Gln Leu Tyr Gln Gly Asp Val Asp Lys 
                165                 170                 175     


Thr Glu Arg Ala Ile Ile Arg Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Gly Ala Cys His Arg Lys Gly Leu Glu Phe Thr Gly Pro Leu 
        195                 200                 205             


Leu Glu Tyr Asn Tyr Ile Glu Asn Leu Phe His Met Ser Gly Met Leu 
    210                 215                 220                 


Asp Glu Leu Thr Gly Lys Pro Asp Ala Met Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Arg Phe Ala Ala Leu Asn Met Asp His Gly Leu Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Ile Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Ala Ala Ala Trp Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Asp Ala Ala His Leu Asn Leu Arg Ser Val Gly Asp Lys Ser Lys Val 
    290                 295                 300                 


Pro Glu Phe Ile Thr Asp Val Lys Asn Gly Lys Lys Lys Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Ser Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Arg Glu Leu Val Asp Glu Ser Ala Ala Gln Ser Asp Pro Ile Val Glu 
            340                 345                 350         


Met Gly Arg Glu Val Glu Lys Val Ala Ser Asn Asp Glu Tyr Phe Thr 
        355                 360                 365             


Thr Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Thr Ala Val Gly Phe Gln Thr Glu Phe Ile Pro Val Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Val Leu Gly Ile Ile Ala His Trp Arg Glu Ala Val Ala Asp 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  278
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 268

<400>  278

Met Ser Asn Ala Phe Leu Tyr Leu Arg Asp Ser Arg Thr Thr Asn Glu 
1               5                   10                  15      


Tyr Arg Val Pro Ile Gln Arg Asn Ala Leu Leu Gly Thr Ala Tyr Lys 
            20                  25                  30          


Glu Ile Lys Ala Pro Thr Ser Ser Gly Asn Arg Ala Asp Lys Val Asp 
        35                  40                  45              


Ser Gly Leu Arg Ile His Asp Pro Gly Leu Leu Asn Thr Ser Val Met 
    50                  55                  60                  


Glu Thr Ala Val Ser Tyr Ala Asp Gly Asp Lys Asp Ile Leu Val Phe 
65                  70                  75                  80  


Arg Gly Tyr Ser Leu Asp Gln Leu Trp Gln Ser Glu Tyr Glu Asp Met 
                85                  90                  95      


Met His Leu Leu Val Trp Ala Lys Tyr Pro Thr Pro Val Gln Lys Asp 
            100                 105                 110         


Ser Leu Lys Lys Ala Leu Ile Ala Ala Met Leu Glu Val Pro Lys Thr 
        115                 120                 125             


Ile Phe Glu Val Val Thr Ala Phe Pro Thr Ala Ser Pro Pro Met Pro 
    130                 135                 140                 


Leu Val Val Gly Ala Leu Ala Ala Tyr Leu Ala Ser Asn Pro Glu Leu 
145                 150                 155                 160 


Ile Pro Ala Thr Gln Gly Ala Asn Ile Tyr Gln Gly Asp Leu Glu Arg 
                165                 170                 175     


Thr Glu Arg Ala Leu Met Arg Thr Ile Ala Ala Tyr Ala Val Val Val 
            180                 185                 190         


Gly Met Gly Ala Cys His Lys Arg Gly Ile Glu Tyr Thr Ala Pro Leu 
        195                 200                 205             


Leu Asp Tyr Asn Phe Ile Glu Asn Leu Phe His Met Ser Gly Met Met 
    210                 215                 220                 


Asp Asp Leu Thr Gly Lys Pro Asp Ala Leu Lys Val Ser Cys Phe Arg 
225                 230                 235                 240 


Lys Tyr Ala Ala Leu Asn Met Asp His Gly Met Ala Leu Ala Val Phe 
                245                 250                 255     


Ser Thr Met Val Thr Ala Ser Ser Leu Thr Asp Pro Ile Ser Cys Leu 
            260                 265                 270         


Val Ala Ser Leu Gly Ala Ala Trp Gly Pro Leu His Phe Gly Ala Thr 
        275                 280                 285             


Asp Ala Ala His Leu Asn Leu Arg Ser Ile Gly Asp Lys Ser Arg Leu 
    290                 295                 300                 


Pro Asp Trp Ile Thr Glu Val Lys Asn Gly Lys Lys Arg Leu Phe Gly 
305                 310                 315                 320 


Tyr Gly His Arg Thr Tyr Lys Gly Thr Asp Pro Arg Val Lys Pro Ile 
                325                 330                 335     


Arg Glu Leu Ile Glu Glu Ser Ala Ala Asn Ser Asp Pro Leu Leu Asp 
            340                 345                 350         


Leu Ala Lys Asp Val Glu Arg Ile Ala Ser Gln Glu Glu Tyr Phe Ser 
        355                 360                 365             


Ser Arg Gly Leu His Pro Asn Ala Asp Phe Tyr Gly Asn Phe Val Phe 
    370                 375                 380                 


Ser Ala Val Gly Phe Gln Thr Asp Phe Ile Pro Ile Ala Met Ile Ser 
385                 390                 395                 400 


Gln Arg Leu Ile Gly Ile Leu Ala His Trp Arg Glu Ala Ile Ala Asp 
                405                 410                 415     


Ser Ser Asp Thr 
            420 


<210>  279
<211>  1516
<212>  DNA
<213>  Bipolaris maydis

<400>  279
atgtcatcga caccttatga tcaggtcatc attgatatca agaattacgt atttcattat       60

cacattattg atgaggatgc cttcatttgc gcgcggatgg cgctcctcga tgccatggga      120

tgtgctatcg aaacgatctc ttcgagtgac gagtgtggca aattactagg gccaattgac      180

ccaactacag taaatccaaa tggttttagg ttgcctggta cttcatattt acttgaccca      240

ctgaaaggcg ctttcgacat ggcaacaatc attcgatatt tggatcataa cgatgcgatc      300

gcgggtgcgg attggggcca cccttctggt gaggacaata cttccaggtt cattctcgca      360

tacttacagt cactcagata atctaggggc tattctggcc gtggcagatt ggcagagcca      420

tcgcattgca aagggagatg tcgtccatac tggtcccaaa ttaacgatgc gcacacttct      480

tatagccatg atcaaggcgt atgaaatcca aggatgcttt cttttaagaa atgctttcaa      540

caaacaggga ttagaccacg tcattctcgt caagttagca tctactgccg tggttgcgtg      600

gcttcttggc ctcactgaag aagaaacaat ggctgcaata tcccatgtat ggatggatgg      660

ccatcctctc cgcacttacc gccatggaac aaacactatt cctcgtaagg gctgggctgc      720

tggagatgct tgtatgaggg cggtgcagct tgcccttttt gcgcaagcag gccagcccgg      780

atctaagacg gtactgactg aaccgagatg ggggttctat gatactctgt tcgaaggcca      840

gccgttccaa tttcccaaac catacaatag ctggaccata aaaaatacaa tcttcaaagt      900

catgccggtg gagggtcatg ggattgcagc tgtacaagca gctctgcaac acagtaacct      960

catgcgagcc cgaggccttt gcccggataa gcacatcaag agagttgata tacgaacaac     1020

agccgcagct atcctcatta ttgacaaaca agggtatttg cataacgctg ctgataggga     1080

ccattgcatg caatacatgg ttgctttggc tttgctcaaa ggtgcagttc cagagagtaa     1140

cgattacaag aacgacagcc cttgggcgtg tgacgaacgg ctttcagagc tccgatccca     1200

catccatctt actgaggaca aaaaactcac ccaagactac ttagatctga ataagaaaag     1260

tcttgcatca ggagtaacca tcaccttttc tgacgacacc atttctgaag aaatttttgt     1320

cgagtttcct gttggccatg tccgaagtgc cgacacaacg aagatggttc aagagaagtt     1380

taaaaagaat atgaagctaa aattctctac gcaggagata gagcgagtga aaatggctgt     1440

ggaaataccc gacatcatga tttcagactt cttgggtctt ttcgctcaag gtcgacacaa     1500

tgagcagaaa ttataa                                                     1516


<210>  280
<211>  488
<212>  PRT
<213>  Bipolaris maydis

<400>  280

Met Ser Ser Thr Pro Tyr Asp Gln Val Ile Ile Asp Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Ile Asp Glu Asp Ala Phe Ile Cys Ala Arg 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Ile Ser Ser 
        35                  40                  45              


Ser Asp Glu Cys Gly Lys Leu Leu Gly Pro Ile Asp Pro Thr Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Thr Ser Tyr Leu Leu Asp Pro 
65                  70                  75                  80  


Leu Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Leu Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Ile Ala Met Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Leu Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Lys Gln Gly Leu Asp His Val Ile Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Met Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Thr Val Leu Thr Glu Pro Arg Trp Gly Phe 
                245                 250                 255     


Tyr Asp Thr Leu Phe Glu Gly Gln Pro Phe Gln Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Thr Ile Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Met Arg Ala Arg Gly Leu Cys Pro Asp Lys His Ile Lys Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Thr Ala Ala Ala Ile Leu Ile Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Ala Ala Asp Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Leu Ala Leu Leu Lys Gly Ala Val Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Leu Thr Glu Asp Lys Lys Leu Thr Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Lys Lys Ser Leu Ala Ser Gly Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Thr Ile Ser Glu Glu Ile Phe Val Glu Phe Pro Val Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Lys Met Val Gln Glu Lys Phe Lys Lys Asn Met 
        435                 440                 445             


Lys Leu Lys Phe Ser Thr Gln Glu Ile Glu Arg Val Lys Met Ala Val 
    450                 455                 460                 


Glu Ile Pro Asp Ile Met Ile Ser Asp Phe Leu Gly Leu Phe Ala Gln 
465                 470                 475                 480 


Gly Arg His Asn Glu Gln Lys Leu 
                485             


<210>  281
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  281

Met Ser Ser Thr Pro Tyr Asp Gln Leu Ile Ile Asp Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Phe His Ile Ile Asp Glu Asp Ala Phe Ile Cys Ala Arg 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Ile Ser Ser 
        35                  40                  45              


Ser Asp Glu Cys Gly Lys Leu Leu Gly Pro Ile Asp Pro Thr Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Thr Ser Tyr Leu Val Asp Pro 
65                  70                  75                  80  


Leu Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Val Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Ile Ala Ile Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Leu Lys 
145                 150                 155                 160 


Asn Ala Phe Asn Lys Gln Gly Leu Asp His Val Ile Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Met Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Leu Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Thr Ile Leu Thr Glu Pro Lys Trp Gly Phe 
                245                 250                 255     


Tyr Asp Thr Leu Phe Asp Gly Gln Pro Phe Gln Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Thr Ile Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Ala His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Met Arg Ala Arg Gly Leu Cys Pro Asp Lys His Ile Lys Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Thr Ala Ala Ala Ile Leu Ile Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Met His Asn Ala Ala Asp Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Val Ala Leu Leu Lys Gly Ala Ile Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Leu Thr Glu Asp Lys Lys Leu Thr Gln Asp Tyr Leu Glu Leu 
385                 390                 395                 400 


Asn Lys Arg Thr Leu Gly Ser Gly Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Thr Ile Ser Glu Glu Ile Phe Val Glu Phe Pro Val Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Lys Met Val Gln Glu Lys Phe Lys Lys Gln Ile 
        435                 440                 445             


Lys Leu Lys Phe Ser Thr Gln Glu Ile Glu Arg Val Lys Val Gly Val 
    450                 455                 460                 


Glu Ile Pro Asp Leu Met Ile Ser Asp Phe Met Gly Leu Tyr Ala Gln 
465                 470                 475                 480 


Gly Arg His Asn Glu Gln Lys Leu 
                485             


<210>  282
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  282

Met Ser Ser Thr Pro Phe Asp Gln Val Ile Ile Glu Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Ile Asp Glu Asp Ala Phe Ile Cys Ala Lys 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Leu Ser Ser 
        35                  40                  45              


Ser Asp Glu Cys Gly Lys Ile Leu Ala Pro Ile Asp Pro Thr Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Thr Ser Tyr Leu Val Asp Pro 
65                  70                  75                  80  


Leu Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Gly Ala Asp Trp Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Lys Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Leu Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Ile Ala Met Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Met Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Lys Gln Gly Leu Asp His Val Ile Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Met Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Trp Arg His Gly Thr Asn Ser Ile Pro Arg Lys Gly Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Ser Val Leu Thr Glu Pro Arg Trp Gly Phe 
                245                 250                 255     


Tyr Asp Thr Leu Phe Glu Gly Gln Pro Phe Gln Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Val Lys Asn Thr Ile Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Met Arg Ala Arg Gly Ile Cys Pro Asp Lys His Ile Lys Arg Val Asp 
305                 310                 315                 320 


Ile Lys Thr Thr Ala Ala Ala Ile Met Val Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Ala Ala Asp Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Val Ala Leu Leu Lys Gly Gly Leu Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Val Thr Glu Asp Lys Lys Leu Thr Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Lys Arg Ser Ile Ala Ser Ala Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Thr Ile Ser Glu Glu Ile Phe Val Glu Phe Pro Val Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Lys Met Val Gln Glu Lys Phe Lys Lys Asn Met 
        435                 440                 445             


Lys Leu Lys Phe Ser Thr Gln Glu Ile Glu Arg Val Lys Met Ala Val 
    450                 455                 460                 


Glu Ile Pro Asp Leu Met Ile Ser Asp Phe Leu Gly Leu Phe Ala Gln 
465                 470                 475                 480 


Gly Arg His Asn Glu Gln Lys Leu 
                485             


<210>  283
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  283

Met Ser Ser Thr Pro Tyr Asp Gln Leu Ile Ile Asp Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Val Ile Asp Glu Glu Ala Phe Ile Cys Ala Lys 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Ile Ser Ser 
        35                  40                  45              


Ser Asp Glu Cys Gly Lys Leu Met Gly Pro Ile Asp Pro Thr Ser Ile 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Ser Thr Tyr Leu Leu Asp Pro 
65                  70                  75                  80  


Leu Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Val Ala Gly Ala Asp Phe Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Lys Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Val Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Ile Ala Val Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Leu Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Lys Gln Gly Leu Asp His Val Ile Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Met Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Thr Ile Pro Arg Lys Gly Tyr Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Thr Val Leu Thr Glu Pro Arg Trp Gly Phe 
                245                 250                 255     


Tyr Asp Thr Leu Phe Glu Gly Gln Pro Phe Gln Tyr Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Thr Leu Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Ile Lys Ala Arg Gly Val Cys Pro Asp Lys His Ile Arg Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Thr Ala Ala Ala Ile Leu Leu Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Gly Ala Asp Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Val Ala Leu Ile Lys Gly Ala Leu Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Leu Thr Glu Asp Lys Lys Leu Thr Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Lys Lys Ser Ile Ala Ser Gly Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Ser Val Ser Asp Glu Ile Phe Val Asp Phe Pro Val Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Lys Met Val Gln Glu Lys Phe Arg Lys Asn Met 
        435                 440                 445             


Lys Leu Lys Phe Ser Thr Gln Glu Ile Glu Arg Val Lys Met Ala Val 
    450                 455                 460                 


Glu Ile Pro Asp Met Met Val Ser Asp Phe Ile Gly Leu Phe Ala Gln 
465                 470                 475                 480 


Gly Arg His Asn Glu Gln Lys Leu 
                485             


<210>  284
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  284

Met Ser Ser Thr Pro Tyr Asp Gln Leu Ile Ile Asp Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Leu Asp Glu Asp Ala Phe Ile Cys Ala Lys 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Ile Ser Ser 
        35                  40                  45              


Thr Asp Glu Cys Gly Lys Met Leu Gly Pro Ile Asp Pro Thr Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Thr Ser Tyr Leu Leu Asp Pro 
65                  70                  75                  80  


Leu Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Ala Ala Glu Trp Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Leu Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Ile Ala Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Val Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Arg Asn Gly Leu Asp His Val Leu Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Val Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Ser Ile Pro Arg Lys Gly Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Ser Val Leu Thr Glu Pro Arg Trp Gly Phe 
                245                 250                 255     


Phe Glu Thr Leu Phe Glu Gly Gln Pro Phe Gln Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Thr Leu Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Met Lys Ala Arg Gly Leu Cys Pro Asp Lys His Ile Lys Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Thr Ala Ala Ala Val Leu Val Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Gly Ala Asp Arg Asp His Cys Met Gln Tyr Leu Val Ala 
            340                 345                 350         


Leu Ala Leu Leu Lys Gly Ala Val Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Leu Thr Glu Asp Lys Lys Leu Ser Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Gln Lys Arg Ser Leu Ala Ser Gly Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Thr Ile Ser Glu Glu Ile Phe Val Glu Tyr Pro Val Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Ser Lys Met Val Gln Glu Lys Phe Lys Lys Asn Met 
        435                 440                 445             


Lys Leu Lys Phe Thr Thr Gln Glu Leu Glu Lys Val Lys Met Ala Val 
    450                 455                 460                 


Glu Ile Pro Asp Met Met Val Ser Asp Phe Val Gly Leu Phe Ala Gln 
465                 470                 475                 480 


Ala Arg His Asn Glu Gln Lys Leu 
                485             


<210>  285
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  285

Met Ser Ser Thr Pro Tyr Asp Gln Val Ile Ile Asp Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Ile Asp Glu Glu Ala Tyr Ile Cys Ala Arg 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Leu Ser Ser 
        35                  40                  45              


Ser Asp Glu Cys Gly Lys Leu Leu Ala Pro Ile Asp Pro Ser Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Thr Ser Tyr Leu Leu Asp Pro 
65                  70                  75                  80  


Ile Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Gly Ala Asp Tyr Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Lys Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Ser Gly Pro Lys Ile Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Leu Ala Ile Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Val Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Arg Gln Gly Leu Asp His Val Val Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Asp 
            180                 185                 190         


Thr Met Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Phe Arg His Gly Thr Asn Thr Ile Pro Arg Lys Gly Tyr Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Thr Val Leu Thr Glu Pro Lys Trp Gly Phe 
                245                 250                 255     


Trp Asp Thr Leu Phe Asp Gly Asn Pro Phe Gln Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Thr Ile Phe Lys Ile Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Met Lys Ala Arg Gly Leu Cys Pro Asp Lys His Ile Lys Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Thr Ala Ala Ala Ile Leu Val Leu Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Gly Ala Asp Arg Asp His Cys Met Gln Tyr Ile Val Ala 
            340                 345                 350         


Leu Ala Leu Leu Lys Gly Ala Leu Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Val Ser Glu Asp Lys Lys Val Ser Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Lys Arg Ser Leu Ala Ser Gly Val Thr Ile Thr Phe Thr Asp Asp 
                405                 410                 415     


Thr Ile Thr Glu Glu Ile Tyr Leu Asp Phe Pro Met Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Lys Met Val Gln Glu Lys Phe Arg Lys Asn Val 
        435                 440                 445             


Lys Ile Lys Phe Ser Thr Gln Glu Val Glu Arg Val Lys Met Ala Ile 
    450                 455                 460                 


Glu Ile Pro Asp Met Met Met Ser Glu Phe Leu Gly Leu Phe Ala Gln 
465                 470                 475                 480 


Ala Arg His Asn Glu Gln Lys Leu 
                485             


<210>  286
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  286

Met Ser Ser Thr Pro Tyr Asp Gln Ile Ile Ile Glu Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Leu Asp Glu Asp Ala Tyr Ile Cys Ala Arg 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Leu Ser Ser 
        35                  40                  45              


Thr Glu Glu Cys Gly Lys Leu Val Gly Pro Ile Asp Pro Thr Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Arg Leu Pro Gly Thr Thr Phe Leu Leu Asp Pro 
65                  70                  75                  80  


Leu Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Leu Ala Gly Ala Glu Trp Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Met Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Ile Ala Leu Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Met Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Lys Gln Gly Leu Asp His Val Ile Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Val Ala Ala Ile Ser His Val Phe Val Glu Gly His Pro Leu Arg 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Thr Ile Pro Arg Lys Ala Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Arg Thr Ile Leu Thr Glu Pro Arg Trp Gly Phe 
                245                 250                 255     


Trp Asp Thr Leu Phe Glu Ala Gln Pro Phe Asn Tyr Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Thr Ile Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Met Gln His Ser Asn Ile 
    290                 295                 300                 


Leu Lys Ala Arg Gly Val Cys Pro Asp Lys His Ile Lys Arg Val Glu 
305                 310                 315                 320 


Ile Arg Thr Ser Ala Ala Ala Leu Leu Ile Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Gly Ala Asp Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Leu Ala Leu Leu Lys Gly Gly Val Pro Asp Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Tyr Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Leu Thr Glu Asp Lys Lys Leu Thr Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Gln Lys Arg Thr Leu Ala Ser Gly Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Ser Ile Ser Glu Glu Ile Phe Val Glu Phe Pro Met Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Lys Met Val Gln Glu Lys Phe Lys Lys Asn Met 
        435                 440                 445             


Arg Leu Lys Tyr Ser Thr Asn Glu Leu Glu Lys Val Lys Met Ala Leu 
    450                 455                 460                 


Glu Ile Pro Asp Ile Met Ile Ser Asp Phe Leu Gly Leu Phe Ala Gln 
465                 470                 475                 480 


Gly Arg His Asn Glu Gln Lys Leu 
                485             


<210>  287
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  287

Met Ser Ser Thr Pro Tyr Asp Gln Leu Ile Leu Glu Ile Lys Gln Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Leu Asp Glu Asp Ala Phe Ile Cys Ala Lys 
            20                  25                  30          


Leu Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Leu Ser Thr 
        35                  40                  45              


Ser Asp Glu Cys Gly Lys Met Ile Gly Pro Leu Glu Pro Thr Thr Val 
    50                  55                  60                  


Asn Pro Asn Ala Phe Lys Leu Pro Gly Thr Thr Tyr Leu Leu Asp Pro 
65                  70                  75                  80  


Val Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Trp Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Gly Ala Glu Phe Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Trp Gln Ser His Lys Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Val His Thr Gly Pro Lys Val Thr Met Lys Thr Leu Leu 
    130                 135                 140                 


Leu Ala Met Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Val Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Arg Gln Gly Leu Asp His Val Leu Leu Val Arg Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Met Ala Ala Ile Ser His Val Phe Met Asp Gly His Pro Leu Lys 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Ser Ile Pro Arg Lys Gly Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Gln Leu Ala Met Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Ser Val Leu Thr Glu Pro Arg Trp Gly Phe 
                245                 250                 255     


Tyr Asp Thr Ile Phe Glu Gly Gln Pro Phe Gln Tyr Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Ser Leu Lys Asn Thr Leu Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Ile Gln His Ser Asn Leu 
    290                 295                 300                 


Val Lys Ala Arg Gly Val Cys Pro Asp Lys His Ile Arg Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Thr Gly Gly Gly Leu Leu Val Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Ala Ala Glu Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Val Ala Leu Leu Lys Gly Ala Val Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Trp Ala Cys Asp Glu Arg Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Met Thr Glu Asp Lys Lys Val Thr Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Arg Arg Ser Ile Ala Ser Ala Val Thr Ile Thr Phe Thr Asp Asp 
                405                 410                 415     


Thr Val Ser Glu Glu Ile Tyr Ile Asp Tyr Pro Ile Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Thr Thr Arg Met Val Gln Glu Lys Phe Arg Lys Asn Leu 
        435                 440                 445             


Arg Leu Lys Phe Ser Thr Gln Glu Ile Asp Arg Val Lys Met Ala Leu 
    450                 455                 460                 


Glu Ile Pro Asp Leu Val Val Ser Asp Phe Val Ala Leu Phe Ala Gln 
465                 470                 475                 480 


Gly Arg His Asn Glu Gln Lys Leu 
                485             


<210>  288
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  288

Met Ser Ser Thr Pro Tyr Asp Gln Met Leu Val Asp Ile Lys Gln Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Ile Asp Glu Asp Ala Phe Ile Cys Ala Lys 
            20                  25                  30          


Met Gly Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Leu Ser Thr 
        35                  40                  45              


Ser Glu Glu Cys Gly Lys Leu Ile Ala Pro Leu Asp Pro Thr Thr Leu 
    50                  55                  60                  


Gln Pro Asn Gly Phe Arg Leu Pro Gly Ser Ser Phe Leu Leu Asp Pro 
65                  70                  75                  80  


Val Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Phe Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Ala Gly Glu Tyr Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Tyr Gln Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Ile His Ser Gly Pro Lys Leu Thr Met Arg Thr Leu Leu 
    130                 135                 140                 


Leu Ala Met Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Leu Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Lys Gln Gly Leu Asp His Val Ile Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Glu Glu 
            180                 185                 190         


Thr Leu Ala Ala Ile Ser His Val Trp Val Asp Gly His Pro Leu Lys 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Thr Ile Pro Arg Lys Gly Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Leu Arg Ala Val Gln Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Thr Ile Leu Thr Glu Pro Lys Trp Gly Phe 
                245                 250                 255     


Tyr Asp Thr Leu Phe Asp Gly Gln Pro Phe Gln Phe Pro Arg Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Leu Lys Asn Thr Leu Phe Lys Leu Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Leu Gln His Ser Asn Leu 
    290                 295                 300                 


Ile Lys Ala Arg Gly Leu Cys Pro Asp Lys His Ile Lys Lys Val Glu 
305                 310                 315                 320 


Ile Arg Thr Ser Ala Ala Ala Ile Val Val Ile Asp Lys Gln Gly Tyr 
                325                 330                 335     


Leu His Asn Ala Ala Asp Arg Asp His Cys Met Gln Tyr Ile Val Ala 
            340                 345                 350         


Val Ala Leu Ile Lys Gly Ala Leu Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Glu Ser Pro Phe Ala Cys Asp Glu Lys Leu Ser Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Leu Thr Glu Asp Lys Lys Ile Thr Gln Glu Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Lys Arg Ser Ile Ala Ser Gly Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Thr Val Ser Glu Glu Ile Phe Ile Asp Tyr Pro Ile Gly His Val Lys 
            420                 425                 430         


Thr Ala Asp Ser Thr Lys Met Val Gln Asp Lys Phe Arg Lys Asn Met 
        435                 440                 445             


Lys Leu Lys Phe Ser Thr Gln Glu Ile Glu Arg Val Lys Met Ala Leu 
    450                 455                 460                 


Glu Ile Pro Glu Met Met Ile Thr Glu Phe Leu Ala Leu Phe Ala Asn 
465                 470                 475                 480 


Ala Lys His Asn Glu Gln Lys Leu 
                485             


<210>  289
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  289

Met Ser Ser Thr Pro Tyr Asp Gln Val Ile Ile Asp Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Ile Asp Asp Glu Ala Phe Ile Cys Ala Arg 
            20                  25                  30          


Leu Gly Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Ile Thr Ser 
        35                  40                  45              


Ser Asp Glu Cys Gly Arg Val Val Gly Pro Val Asp Pro Ser Thr Val 
    50                  55                  60                  


Asn Pro Asn Gly Phe Lys Leu Pro Gly Thr Ser Phe Leu Val Asp Pro 
65                  70                  75                  80  


Met Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Tyr Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Ala Ala Glu Tyr Gly His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Phe Gln Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Leu Val His Ser Gly Pro Lys Ile Thr Met Lys Thr Leu Leu 
    130                 135                 140                 


Leu Ala Val Ile Lys Ala Tyr Glu Ile Gln Gly Cys Phe Leu Met Arg 
145                 150                 155                 160 


Asn Gly Phe Asn Arg Gln Gly Leu Asp His Val Leu Leu Val Lys Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Asp Asp Glu 
            180                 185                 190         


Thr Leu Ala Ala Ile Ser His Val Phe Val Asp Gly His Pro Leu Arg 
        195                 200                 205             


Ser Tyr Arg His Gly Ser Asn Ser Ile Pro Arg Lys Ala Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Asn Leu Ala Leu Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Lys Ser Ile Leu Thr Glu Pro Arg Phe Gly Phe 
                245                 250                 255     


Phe Glu Thr Ile Phe Glu Gly Gln Pro Phe Asn Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Leu Lys Gln Ser Leu Phe Lys Ile Met Pro Val Glu 
        275                 280                 285             


Gly His Gly Ile Ala Ala Val Gln Ala Ala Met Gln His Ser Asn Leu 
    290                 295                 300                 


Leu Arg Ala Arg Gly Met Cys Pro Glu Lys His Ile Arg Arg Val Glu 
305                 310                 315                 320 


Ile Lys Thr Ser Ala Ala Gly Ile Leu Val Leu Asp Lys Gln Ala Tyr 
                325                 330                 335     


Leu His Asn Ala Ala Glu Arg Asp His Cys Met Gln Tyr Ile Val Ala 
            340                 345                 350         


Leu Ala Leu Leu Lys Gly Gly Val Pro Glu Ser Asn Asp Tyr Lys Asn 
        355                 360                 365             


Glu Ser Pro Trp Ala Cys Asp Glu Lys Leu Thr Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Val Thr Glu Asp Lys Lys Leu Ser Gln Asp Tyr Leu Glu Leu 
385                 390                 395                 400 


Gln Arg Arg Thr Ile Ala Ser Ala Val Thr Ile Thr Phe Ser Asp Asp 
                405                 410                 415     


Thr Ile Ser Asp Glu Ile Phe Val Asp Tyr Pro Val Gly His Val Arg 
            420                 425                 430         


Ser Ala Asp Ser Ser Lys Met Val Gln Glu Lys Phe Arg Arg Gln Met 
        435                 440                 445             


Lys Leu Arg Tyr Ser Thr Gln Asp Val Glu Arg Val Lys Met Ala Ile 
    450                 455                 460                 


Glu Ile Pro Glu Leu Val Ile Ser Glu Phe Ile Ala Leu Tyr Ala Gln 
465                 470                 475                 480 


Ala Arg His Asn Glu Gln Lys Leu 
                485             


<210>  290
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 280

<400>  290

Met Thr Ser Thr Pro Tyr Asp Gln Val Leu Val Glu Ile Lys Asn Tyr 
1               5                   10                  15      


Val Phe His Tyr His Ile Leu Asp Glu Glu Ala Tyr Ile Cys Ala Lys 
            20                  25                  30          


Met Ala Leu Leu Asp Ala Met Gly Cys Ala Ile Glu Thr Leu Thr Thr 
        35                  40                  45              


Ser Glu Glu Cys Ala Lys Val Met Gly Pro Val Asp Pro Thr Thr Ile 
    50                  55                  60                  


Gln Pro Gln Ala Phe Arg Leu Pro Gly Thr Ser Tyr Leu Leu Asp Pro 
65                  70                  75                  80  


Val Lys Gly Ala Phe Asp Met Ala Thr Ile Ile Arg Trp Leu Asp His 
                85                  90                  95      


Asn Asp Ala Ile Ala Gly Gly Glu Trp Ala His Pro Ser Asp Asn Leu 
            100                 105                 110         


Gly Ala Ile Leu Ala Val Ala Asp Tyr Asn Ser His Arg Ile Ala Lys 
        115                 120                 125             


Gly Asp Val Ile His Ser Gly Pro Lys Ile Thr Met Lys Thr Leu Leu 
    130                 135                 140                 


Ile Ala Val Ile Lys Ala Tyr Glu Ile Gln Ala Cys Phe Leu Val Arg 
145                 150                 155                 160 


Asn Ala Phe Asn Arg Gln Gly Leu Asp His Val Ile Leu Leu Arg Leu 
                165                 170                 175     


Ala Ser Thr Ala Val Val Ala Trp Leu Leu Gly Leu Thr Glu Asp Glu 
            180                 185                 190         


Ser Ile Ala Ala Ile Ser His Val Trp Met Asp Gly His Pro Leu Arg 
        195                 200                 205             


Thr Tyr Arg His Gly Thr Asn Thr Met Pro Arg Lys Ala Trp Ala Ala 
    210                 215                 220                 


Gly Asp Ala Cys Met Arg Ala Val Asn Leu Ala Val Phe Ala Gln Ala 
225                 230                 235                 240 


Gly Gln Pro Gly Ser Arg Thr Ile Leu Thr Glu Pro Lys Tyr Gly Phe 
                245                 250                 255     


Phe Asp Thr Leu Phe Glu Ala Asn Pro Phe Gln Phe Pro Lys Pro Tyr 
            260                 265                 270         


Asn Ser Trp Thr Ile Lys Asn Ser Leu Phe Lys Val Met Pro Val Glu 
        275                 280                 285             


Ala His Gly Ile Gly Ala Val Gln Ala Ala Met Gln His Ser Asn Leu 
    290                 295                 300                 


Ile Arg Ala Arg Gly Leu Cys Pro Asp Lys His Ile Lys Arg Val Asp 
305                 310                 315                 320 


Ile Arg Thr Ser Ala Ala Ala Leu Leu Val Leu Asp Lys Gln Ala Tyr 
                325                 330                 335     


Leu His Asn Gly Ala Glu Arg Asp His Cys Met Gln Tyr Met Val Ala 
            340                 345                 350         


Val Ala Leu Ile Arg Gly Ala Leu Pro Glu Thr Asn Glu Tyr Lys Asn 
        355                 360                 365             


Asp Ser Pro Phe Ala Cys Asp Glu Arg Leu Thr Glu Leu Arg Ser His 
    370                 375                 380                 


Ile His Val Thr Glu Asp Lys Lys Ile Ser Gln Asp Tyr Leu Asp Leu 
385                 390                 395                 400 


Asn Lys Arg Ser Ile Ala Ser Gly Val Thr Ile Thr Phe Thr Asp Asp 
                405                 410                 415     


Thr Val Ser Glu Glu Ile Tyr Val Asp Tyr Pro Leu Gly His Ile Arg 
            420                 425                 430         


Ser Ala Asp Ser Thr Lys Met Val Gln Glu Lys Phe Arg Lys Asn Val 
        435                 440                 445             


Arg Leu Arg Phe Ser Thr Gln Glu Ile Glu Arg Val Lys Met Ala Val 
    450                 455                 460                 


Asp Ile Pro Glu Met Met Val Ser Asp Phe Met Ala Leu Trp Ala Asn 
465                 470                 475                 480 


Ala Arg His Asn Glu Gln Lys Leu 
                485             


<210>  291
<211>  677
<212>  DNA
<213>  Bipolaris maydis

<400>  291
atgatacttt tttacctatt gccactgttt gcagttgctc aaaccccgcc tgaattctca       60

ccttcatgca caaaatcact cgacgtgacc tattcaaata aacagcctgt ccgcccaggt      120

caaattttgc gtcaaatagg tctggaattc ccataatctt ataagaaact gctaacgaaa      180

tgcaaacaac agatgtcgta acacagcccg tcttgagacc cacgcatctt caaccagata      240

ccaattacat cgtcttcttg attgaccccg acgttgtcca cgactacaat gccacaacca      300

ttcttcattg gtatcaacca aattgtcacg tatctcaagc tacaggcgat tttgtggtac      360

ctacagagga tggtgcccaa tatgttggct cgcaacctcc cccgggagaa aagcatcgtt      420

acatcttctt gcttttcgaa caacctctga aatatgtgtt cccgcaatgt ttccaaacta      480

tattccccgt ctccgtcgct tccaggtctg ggtttgacat tacgtatttt atggaaatta      540

ctggactcgg aagccccgtt gcggcaaatt ggttttctgt tgagagggct ggcgaggcta      600

gcacgaccag agtcataacc acaacaagcc tcaatcacgc tccatgcaag gcaacacaag      660

tggtcaggca cttgtga                                                     677


<210>  292
<211>  207
<212>  PRT
<213>  Bipolaris maydis

<400>  292

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Ser Pro Ser Cys Thr Lys Ser Leu Asp Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Arg Pro Gly Gln Ile Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Val Thr Gln Pro Val Leu Arg Pro Thr His Leu Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Thr Thr Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Ser Gln Ala 
                85                  90                  95      


Thr Gly Asp Phe Val Val Pro Thr Glu Asp Gly Ala Gln Tyr Val Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Leu Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Lys Tyr Val Phe Pro Gln Cys Phe Gln Thr Ile Phe 
    130                 135                 140                 


Pro Val Ser Val Ala Ser Arg Ser Gly Phe Asp Ile Thr Tyr Phe Met 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Ser Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  293
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  293

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Ser Pro Ser Cys Ser Lys Thr Leu Glu Val Thr Tyr Ser 
            20                  25                  30          


Asn Arg Gln Pro Val Arg Pro Gly Asn Ile Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Val Thr Gln Pro Val Leu Arg Pro Thr His Leu Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Thr Thr Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Ser Gln Ala 
                85                  90                  95      


Thr Gly Asp Phe Leu Leu Pro Thr Glu Asp Gly Ala Gln Tyr Val Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Val Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Lys Tyr Val Phe Pro Gln Cys Phe Gln Thr Leu Phe 
    130                 135                 140                 


Pro Val Thr Val Ala Ser Arg Ser Gly Phe Asp Val Thr Tyr Phe Met 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Ser Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  294
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  294

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Ser Pro Ser Cys Thr Lys Ser Leu Asp Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Arg Pro Gly Asn Ile Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Val Thr Gln Pro Val Leu Lys Pro Thr His Leu Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Thr Thr Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Thr Gln Gly 
                85                  90                  95      


Thr Gly Asp Phe Ile Met Pro Thr Glu Asp Gly Ala Gln Tyr Leu Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Val Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Lys Tyr Val Phe Pro Gln Cys Phe Gln Thr Ile Phe 
    130                 135                 140                 


Pro Val Ser Ile Ala Ser Arg Ser Gly Phe Asp Ile Thr Tyr Phe Met 
145                 150                 155                 160 


Glu Leu Thr Gly Leu Gly Thr Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Ser Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  295
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  295

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Asp Phe Thr Pro Ser Cys Ser Lys Thr Leu Asp Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Arg Pro Gly Asn Val Leu Lys Gln Val Asp Val 
        35                  40                  45              


Val Thr Gln Pro Val Leu Arg Pro Thr His Ile Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Thr Thr Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Thr Gln Ala 
                85                  90                  95      


Thr Gly Asp Phe Val Val Pro Thr Glu Glu Gly Ala Gln Tyr Val Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Leu Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Arg Tyr Val Phe Pro Gln Cys Tyr Gln Thr Leu Phe 
    130                 135                 140                 


Pro Val Ser Val Ala Ser Arg Ser Gly Phe Asp Ile Thr Tyr Phe Ile 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Ser Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  296
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  296

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Thr Pro Ser Cys Thr Lys Ser Leu Asp Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Lys Pro Gly Gln Met Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Val Thr Gln Pro Ile Leu Arg Pro Thr His Leu Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Val Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Thr Ser Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Thr Gln Ala 
                85                  90                  95      


Thr Gly Asp Phe Leu Ile Pro Thr Asp Asp Gly Ala Gln Tyr Val Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Leu Leu Phe 
        115                 120                 125             


Glu Gln Pro Ile Lys Tyr Val Phe Pro Gln Cys Phe Gln Thr Val Phe 
    130                 135                 140                 


Pro Val Thr Val Ala Ser Arg Ser Gly Phe Asp Ile Thr Tyr Phe Met 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Lys Ala Gly Glu Ala Ser Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Val Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  297
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  297

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Thr Pro Ser Cys Thr Lys Ser Leu Asp Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Arg Pro Gly Asn Val Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Met Thr Gln Pro Val Leu Arg Pro Ser His Val Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Ser Thr Val Leu His Trp Tyr Gln Pro Asn Cys His Val Ser Asn Gly 
                85                  90                  95      


Ser Gly Asp Phe Val Ile Pro Thr Asp Glu Gly Ala Gln Tyr Val Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Val Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Arg Tyr Val Phe Pro Gln Cys Phe Gln Thr Ile Phe 
    130                 135                 140                 


Pro Val Ser Val Gly Ser Arg Ser Gly Phe Asp Val Thr Tyr Phe Met 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Lys Ala Ala Glu Ala Thr Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  298
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  298

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Thr Pro Ser Cys Ser Lys Thr Leu Glu Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Arg Pro Gly Gln Val Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Leu Thr Gln Pro Val Leu Arg Pro Thr His Leu Gln Pro Asp Ser Gln 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Thr Thr Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Ser Asn Gly 
                85                  90                  95      


Ser Gly Asp Phe Ile Val Pro Thr Glu Asp Gly Ala Gln Tyr Val Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Val Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Arg Tyr Val Phe Pro Asn Cys Phe Gln Ser Ile Phe 
    130                 135                 140                 


Pro Val Ser Val Ala Ser Arg Ser Gly Phe Asp Leu Thr Tyr Phe Met 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Thr Val 
                165                 170                 175     


Asp Lys Ala Gly Glu Ala Thr Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  299
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  299

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Gln Thr Pro 
1               5                   10                  15      


Pro Asp Phe Thr Pro Ser Cys Ser Lys Thr Leu Glu Val Thr Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Arg Pro Gly Asn Leu Leu Lys Gln Leu Asp Val 
        35                  40                  45              


Ile Ser Gln Pro Val Leu Arg Pro Thr His Val Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Glu Tyr Asn Ala 
65                  70                  75                  80  


Ser Thr Ile Val His Trp Tyr Gln Pro Asn Cys His Val Thr Gln Gly 
                85                  90                  95      


Ser Gly Glu Phe Leu Leu Pro Thr Asp Asp Gly Ala Gln Tyr Ile Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Ile Phe Leu Leu Phe 
        115                 120                 125             


Glu Gln Pro Val Lys Tyr Val Phe Pro Gln Cys Phe Gln Ser Leu Phe 
    130                 135                 140                 


Pro Val Thr Val Gly Thr Arg Ser Gly Phe Asp Ile Ser Tyr Phe Ile 
145                 150                 155                 160 


Glu Ile Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Ser Thr Thr Arg Val Val Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  300
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  300

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Val Ala Asn Thr Pro 
1               5                   10                  15      


Pro Asp Phe Thr Pro Thr Cys Ser Lys Ser Leu Asp Val Ser Tyr Ser 
            20                  25                  30          


Asn Lys Gln Pro Val Lys Pro Gly Gln Leu Leu Arg Gln Ile Asp Val 
        35                  40                  45              


Val Thr Asn Pro Leu Leu Arg Pro Ser His Val Gln Pro Asp Thr Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Ile Asp Pro Asp Val Val His Glu Tyr Asn Ala 
65                  70                  75                  80  


Thr Thr Ile Leu His Trp Tyr Gln Pro Asn Cys His Val Ser Asn Gly 
                85                  90                  95      


Ser Gly Glu Phe Ile Ile Pro Thr Asp Asp Gly Ala Asn Tyr Val Gly 
            100                 105                 110         


Ser Asn Pro Pro Pro Gly Glu Lys His Arg Tyr Val Phe Ile Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Lys Tyr Val Phe Pro Asn Cys Phe Gln Thr Ile Phe 
    130                 135                 140                 


Pro Val Thr Leu Ala Ser Arg Thr Gly Phe Asp Val Thr Tyr Phe Leu 
145                 150                 155                 160 


Glu Leu Thr Gly Leu Gly Thr Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Ser Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  301
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  301

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Leu Ala Gln Thr Pro 
1               5                   10                  15      


Pro Asp Phe Thr Pro Ser Cys Ser Lys Ser Leu Glu Val Ser Tyr Ser 
            20                  25                  30          


Gln Lys Gln Pro Val Lys Pro Gly Asn Leu Leu Lys Gln Ile Asp Leu 
        35                  40                  45              


Val Thr Gln Pro Val Leu Arg Pro Ser His Val Gln Pro Asp Thr Gln 
    50                  55                  60                  


Tyr Ile Val Phe Leu Val Asp Pro Asp Val Val His Asp Tyr Asn Ala 
65                  70                  75                  80  


Ser Thr Ile Val His Trp Tyr Gln Pro Asn Cys His Ile Thr Asn Gly 
                85                  90                  95      


Ser Gly Glu Phe Val Val Pro Thr Asp Glu Ala Ala Gln Tyr Leu Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Val Phe Val Leu Phe 
        115                 120                 125             


Glu Gln Pro Leu Arg Tyr Val Phe Pro Gln Cys Phe Gln Ser Leu Phe 
    130                 135                 140                 


Pro Leu Thr Leu Ala Ser Arg Ser Gly Phe Asp Val Ser Tyr Phe Val 
145                 150                 155                 160 


Glu Leu Thr Gly Leu Gly Ser Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Arg Ala Gly Glu Ala Thr Thr Thr Arg Val Ile Thr Thr Thr Ser 
            180                 185                 190         


Val Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  302
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 292

<400>  302

Met Ile Leu Phe Tyr Leu Leu Pro Leu Phe Ala Leu Ala Gln Thr Pro 
1               5                   10                  15      


Pro Glu Phe Ser Pro Ser Cys Ser Lys Thr Leu Glu Val Thr Tyr Ser 
            20                  25                  30          


Gln Lys Gln Pro Val Lys Pro Gly Asn Val Leu Lys Gln Ile Asp Val 
        35                  40                  45              


Val Thr Gln Pro Val Leu Arg Pro Ser His Val Gln Pro Asp Ser Asn 
    50                  55                  60                  


Tyr Ile Val Phe Leu Val Asp Pro Asp Val Val His Glu Tyr Asn Ala 
65                  70                  75                  80  


Ser Thr Met Leu His Trp Tyr Gln Pro Asn Cys His Val Thr Gln Gly 
                85                  90                  95      


Thr Gly Glu Phe Leu Val Pro Thr Asp Glu Gly Ala Asn Tyr Leu Gly 
            100                 105                 110         


Ser Gln Pro Pro Pro Gly Glu Lys His Arg Tyr Val Phe Ile Leu Phe 
        115                 120                 125             


Glu Gln Pro Val Lys Tyr Val Phe Pro Gln Cys Tyr Asn Ser Leu Phe 
    130                 135                 140                 


Pro Met Thr Ile Ala Thr Arg Ser Gly Phe Asp Leu Thr Tyr Phe Val 
145                 150                 155                 160 


Glu Val Thr Ala Leu Gly Thr Pro Val Ala Ala Asn Trp Phe Ser Val 
                165                 170                 175     


Glu Lys Ala Gly Glu Ala Ser Thr Thr Arg Val Val Thr Thr Thr Ser 
            180                 185                 190         


Leu Asn His Ala Pro Cys Lys Ala Thr Gln Val Val Arg His Leu 
        195                 200                 205         


<210>  303
<211>  762
<212>  DNA
<213>  Bipolaris maydis

<400>  303
atgccgccat taagagtcct ctgcctccat ggggcaggga caaatacaga ggtattctga       60

tacaaatttc caatgagaat atactaacag aggttaagat cctccagttt cagcttcgta      120

atacttccct gccttcgaac gatcatgctc taacaattcc atcaaggacc tttgattcgt      180

gagcttgaat cggatcatac tgcaactttc cattttaccg aaggggttgt tgactctggc      240

cctgggccta acgttgagaa ttttttcgaa ggcccatact actcctacta caactggccg      300

cggtcatcag aggatgatgg cactactgtg gaagaagcat acgatcaact tttggatttt      360

attgagatag aagggccttt tgacgcagtg atcggctttt cgcatggcgg taccctcgct      420

tgtgggtttc tcgctcagtg gtcaacgcgc cacccatacg aagctccacc attcaaatgc      480

gcaattttct tcaacagctt acctccgttt gtggttagcg ggagcggaaa tttcatattt      540

gagaagcatc taaagggcaa gataaccatt cctacacttc atgttgttgg gagaaaggac      600

tttatttacg agcactctct caagctacat cagatatgcg gggacaaaaa agcaaccttg      660

atgctacatg acaacgggca tgaaatcccc agagagccaa aattcgtggc aaaaatcgcg      720

ggtgcaatca ggagattaag tcgcgaaatt atgttccaat ag                         762


<210>  304
<211>  221
<212>  PRT
<213>  Bipolaris maydis

<400>  304

Met Pro Pro Leu Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Leu Arg Pro Leu Ile Arg Glu Leu Glu Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Asp Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Val Glu Asn Phe Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Arg Ser Ser Glu Asp Asp Gly Thr Thr Val Glu Glu 
65                  70                  75                  80  


Ala Tyr Asp Gln Leu Leu Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Val Ser Gly Ser Gly 
    130                 135                 140                 


Asn Phe Ile Phe Glu Lys His Leu Lys Gly Lys Ile Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Lys 
                165                 170                 175     


Leu His Gln Ile Cys Gly Asp Lys Lys Ala Thr Leu Met Leu His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Glu Pro Lys Phe Val Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Arg Arg Leu Ser Arg Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  305
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  305

Met Pro Pro Met Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Glu Val Leu Gln Phe Gln Leu Arg Pro Leu Ile Lys Asp Leu Glu Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Asp Ser Ala 
        35                  40                  45              


Pro Gly Pro Asn Val Glu Asn Phe Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Phe Pro Arg Thr Ser Glu Asp Asp Gly Thr Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Tyr Glu Gln Leu Leu Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Ala Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Val Ser Gly Ser Gly 
    130                 135                 140                 


Asn Phe Ile Phe Glu Lys His Leu Lys Gly Lys Ile Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Lys 
                165                 170                 175     


Leu His Gln Ile Cys Gly Asp Lys Lys Ala Thr Leu Met Leu His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Lys Asp Pro Lys Phe Val Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Arg Arg Leu Ser Arg Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  306
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  306

Met Pro Pro Leu Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Val Arg Pro Leu Ile Arg Glu Leu Asp Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Asp Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Leu Glu Asn Phe Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Arg Ser Ser Glu Asp Asp Gly Thr Thr Met Glu Asp 
65                  70                  75                  80  


Ala Tyr Asp Gln Leu Leu Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Asp Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Val Ser Gly Ser Gly 
    130                 135                 140                 


Asn Phe Ile Phe Glu Lys His Val Lys Gly Lys Ile Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Arg 
                165                 170                 175     


Leu His Gln Val Cys Gly Asp Lys Lys Ala Thr Val Met Leu His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Glu Pro Lys Phe Leu Ala Lys Ile Ala 
        195                 200                 205             


Ala Ala Ile Arg Arg Leu Ser Arg Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  307
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  307

Met Pro Pro Leu Arg Val Leu Cys Leu His Gly Gly Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Leu Arg Pro Leu Val Lys Glu Leu Glu Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Asp Ser Ala 
        35                  40                  45              


Pro Gly Pro Asn Val Glu Asn Phe Phe Glu Gly Pro Phe Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Lys Ser Ser Asp Asp Asp Gly Thr Thr Val Glu Glu 
65                  70                  75                  80  


Ala Tyr Asp Gln Leu Leu Glu Trp Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Tyr Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Val Ser Ala Ser Gly 
    130                 135                 140                 


Asn Phe Val Phe Glu Lys His Leu Lys Ala Lys Ile Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Lys 
                165                 170                 175     


Leu His Gln Ile Cys Gly Asp Lys Lys Ala Thr Leu Met Leu His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Asp Pro Lys Phe Val Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Arg Lys Ile Ser Arg Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  308
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  308

Met Pro Pro Met Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Asp Ile Leu Gln Phe Gln Val Arg Pro Leu Ile Arg Glu Leu Asp Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Glu Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Val Glu Asn Phe Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Phe Pro Arg Ser Ser Glu Asp Asp Gly Thr Thr Leu Glu Glu 
65                  70                  75                  80  


Ala Tyr Asp Gln Leu Met Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Val Ser Ala Ser Gly 
    130                 135                 140                 


Asn Phe Ile Phe Glu Lys His Leu Lys Gly Lys Leu Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Lys 
                165                 170                 175     


Leu His Gln Ile Cys Gly Asp Lys Lys Ala Thr Leu Met Leu His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Lys Glu Pro Lys Phe Val Ala Lys Ile Ala 
        195                 200                 205             


Ala Ala Ile Lys Lys Val Ser Lys Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  309
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  309

Met Pro Pro Leu Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Asp Ile Leu Gln Phe Gln Leu Lys Pro Leu Ile Arg Glu Leu Glu Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Met Asp Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Leu Glu Asn Phe Tyr Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Arg Ser Ser Glu Asp Asp Gly Ser Thr Ile Asp Glu 
65                  70                  75                  80  


Ala Tyr Asp Gln Leu Leu Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Tyr Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Leu Ser Gly Ser Gly 
    130                 135                 140                 


Asn Trp Ile Phe Glu Lys His Leu Lys Gly Lys Ile Ser Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Arg 
                165                 170                 175     


Leu His Gln Val Cys Ala Glu Lys Arg Ala Thr Leu Met Leu His Asp 
            180                 185                 190         


Asn Gly His Asp Ile Pro Arg Asp Pro Lys Phe Val Gly Lys Ile Ala 
        195                 200                 205             


Ala Ala Ile Lys Arg Met Ser Arg Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  310
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  310

Met Pro Pro Met Arg Val Leu Cys Leu His Gly Gly Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Leu Arg Pro Leu Ile Lys Glu Leu Glu Ser 
            20                  25                  30          


Glu His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Glu Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Ile Glu Asn Tyr Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Arg Ser Ser Asp Asp Asp Gly Thr Thr Met Glu Glu 
65                  70                  75                  80  


Ala Tyr Asp Gln Leu Leu Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Leu Ser Gly Ser Ala 
    130                 135                 140                 


Asn Phe Met Phe Glu Lys His Leu Lys Gly Lys Val Ser Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Lys Lys Asp Phe Ile Tyr Asp His Ser Leu Lys 
                165                 170                 175     


Leu His Asn Val Cys Gly Asp Arg Lys Ala Thr Val Leu Leu His Glu 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Glu Pro Lys Tyr Val Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Arg Arg Leu Ser Arg Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  311
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  311

Met Pro Pro Leu Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Asp Ile Leu Gln Phe Gln Met Arg Pro Leu Ile Lys Asp Leu Glu Ser 
            20                  25                  30          


Glu His Ser Ala Thr Phe His Phe Thr Asp Gly Val Leu Asp Ser Gly 
        35                  40                  45              


Pro Ala Pro Asn Leu Glu Asn Phe Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Arg Ser Ser Glu Asp Asp Ala Thr Thr Val Asp Asp 
65                  70                  75                  80  


Ala Tyr Glu Gln Leu Leu Glu Tyr Ile Asp Ile Glu Gly Pro Tyr Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Glu Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Tyr Val Ile Ser Ala Ser Gly 
    130                 135                 140                 


Asn Phe Ile Phe Asp Lys His Leu Lys Gly Lys Leu Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Asp His Ser Ile Lys 
                165                 170                 175     


Leu His Gln Met Cys Gly Asp Lys Lys Ala Thr Val Ile Met His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Glu Pro Arg Trp Ile Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Arg Arg Val Ser Lys Glu Ile Met Phe Gln 
    210                 215                 220     


<210>  312
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  312

Met Pro Pro Ile Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Leu Arg Pro Leu Ile Lys Glu Leu Glu Ser 
            20                  25                  30          


Asp His Thr Ala Thr Phe His Phe Thr Glu Gly Val Val Asp Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Leu Asp Asn Phe Phe Glu Gly Pro Tyr Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Phe Pro Arg Ser Thr Asp Asp Asp Gly Thr Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Tyr Glu Gln Leu Leu Asp Trp Ile Asp Ile Asp Gly Pro Tyr Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Ala Phe Leu 
            100                 105                 110         


Ala Gln Phe Ser Thr Lys His Pro Tyr Asp Ala Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Leu Thr Ala Ser Gly 
    130                 135                 140                 


Asn Phe Val Trp Glu Lys His Leu Lys Ala Lys Leu Thr Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Leu Lys 
                165                 170                 175     


Leu His Gln Leu Cys Gly Asp Arg Lys Ala Thr Val Val Leu His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Asp Pro Lys Phe Leu Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Lys Arg Met Ser Lys Glu Val Met Phe Gln 
    210                 215                 220     


<210>  313
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  313

Met Pro Pro Met Arg Val Leu Cys Leu His Gly Ala Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Leu Arg Pro Leu Val Lys Glu Leu Asp Thr 
            20                  25                  30          


Asp His Ser Ala Thr Phe His Phe Thr Glu Gly Val Met Asp Ser Ala 
        35                  40                  45              


Pro Gly Pro Asn Ile Glu Asn Tyr Tyr Glu Gly Pro Phe Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Tyr Pro Arg Ser Thr Glu Glu Asp Gly Ser Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Phe Glu Gln Leu Val Glu Phe Ile Asp Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Ala Phe Leu 
            100                 105                 110         


Ala Gln Tyr Ser Thr Arg His Pro Tyr Glu Gly Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Val Met Ser Ala Thr Gly 
    130                 135                 140                 


Asn Phe Leu Phe Glu Lys His Leu Lys Gly Arg Leu Ser Ile Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Arg Lys Asp Phe Ile Tyr Glu His Ser Ile Lys 
                165                 170                 175     


Leu His Gln Met Cys Gly Asp Lys Arg Ala Thr Val Val Ile His Asp 
            180                 185                 190         


Asn Gly His Glu Ile Pro Lys Glu Pro Lys Phe Leu Ala Lys Ile Ala 
        195                 200                 205             


Ala Ala Ile Arg Lys Ile Ser Arg Asp Leu Met Phe Gln 
    210                 215                 220     


<210>  314
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 304

<400>  314

Met Pro Pro Leu Arg Val Leu Cys Leu His Gly Gly Gly Thr Asn Thr 
1               5                   10                  15      


Glu Ile Leu Gln Phe Gln Leu Arg Pro Leu Ile Lys Glu Leu Glu Ser 
            20                  25                  30          


Asp His Ser Ala Thr Phe His Phe Thr Asp Gly Val Leu Asp Ser Gly 
        35                  40                  45              


Pro Gly Pro Asn Ile Glu Asn Tyr Phe Asp Gly Pro Phe Tyr Ser Tyr 
    50                  55                  60                  


Tyr Asn Trp Pro Arg Ser Thr Glu Glu Glu Gly Thr Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Phe Asp Gln Leu Leu Asp Phe Ile Glu Ile Glu Gly Pro Phe Asp 
                85                  90                  95      


Ala Val Ile Gly Phe Ser His Gly Gly Thr Leu Ala Cys Gly Phe Leu 
            100                 105                 110         


Ala Gln Trp Ser Thr Arg His Pro Tyr Glu Gly Pro Pro Phe Lys Cys 
        115                 120                 125             


Ala Ile Phe Phe Asn Ser Leu Pro Pro Phe Leu Ile Thr Ala Ser Ala 
    130                 135                 140                 


Gln Phe Ile Trp Glu Lys His Leu Lys Ala Arg Val Thr Val Pro Thr 
145                 150                 155                 160 


Leu His Val Val Gly Lys Arg Asp Tyr Ile Tyr Glu His Ser Met Arg 
                165                 170                 175     


Leu His Asn Leu Cys Gly Asp Arg Arg Ala Ser Val Leu Val His Glu 
            180                 185                 190         


Asn Gly His Glu Ile Pro Arg Glu Pro Lys Tyr Leu Ala Lys Ile Ala 
        195                 200                 205             


Gly Ala Ile Arg Lys Val Ser Arg Glu Ile Ile Phe Gln 
    210                 215                 220     


<210>  315
<211>  1818
<212>  DNA
<213>  Bipolaris maydis

<400>  315
atggcacaac caccagacac agtgcgacct ggcagtcatc tagtaccgag agcaagcatc       60

gactcagcaa ctacacacgc caaaaccgaa cctacgccac caccaccaga tggtggcctt      120

gaagatacac attcaaacac cgaaaatgga ggtcagcaac caacagacgt cgaagctaga      180

gcgaacgcag tgtcaaaagt cgagactcag agcaaaccat tctccatttt cacccatcgt      240

caaaagctcg gtatcgtcat ggcctcagcg gccgcagcct tcttctcgcc tttgacagcc      300

tcagtctatc tgccagcact gcctgccatc gccaaagatt tcggcgtctc gtattccgct      360

atcaacctga cagttacaac gtacatggtc agtaccggcc tgctatgctc aaagatacac      420

acaagtccgc tgctaactca tagaccaaag atattccagg gcatcacgcc aatgttcgtt      480

ggcgcatatg ccgactcggc aggccggcgg ccagcctaca tgttctgctt tatcgtgtac      540

atggcagcca atatcgggtg cgccctcgca cccaactacc cggcgctgct cgtcttgcgc      600

atgctgcaat ccgcaggttc tagcacgact gttgctctgg cgcagggcgt cgtgtctgat      660

atcatcacat cagccgagcg cggtagatac gtgagctaca tgtcgacgcc ggtcttgctg      720

ggcccctcgc tgggccccgt tctgggcggt acactggcac agtatctcgg gtggcggtgg      780

attttctgga tcctgaccat catgtgcggg acgttgactg tagtctttgt gacgtggatg      840

cccgaaacat gtcgggggat tgtgggtgac gggtctgttc ggccccagca tatcgtccac      900

aggtcgcttt ggcgggtcgg caaggacgtg ctggcgacgc gatcgagtcg caaacaacag      960

gcgcaaacca atagacagga cgaagagcac tcggctaccg gaccacggcc ttctgggcag     1020

caagccgtta ccaagcacaa attcaaggcc ctacacgctc taatgctgct tctacagccc     1080

aacatggcct tcctgctgct ctacagcagc ctcatcttcg caaacttcta ctgcatcatg     1140

acctcgatcc ccgcccagtt cacctcgatc taccacctga ccgacctcca gaccgggctt     1200

atctacctcc cgctcggcct gggcacgata gtgggctcac aggttgctgg gcgcagcctg     1260

gactggaact tccggcgaca ctgcaacctg ctcggcctcc cttatgagcg caaaaggcag     1320

caggacctct cttcgttccc gatcgagcgc gcacgactcg aggttggtgt tcctgccctc     1380

atcttggcta cctgcgtggt cctggtctgg ggctgggttc tccacgctcg gacgcacctc     1440

gcagttcctt gcgtgatgct gttcctcgcc ggcctagggc tgactgggtt cagcaacgtc     1500

gtcagcacgc tcattgtgga catgaatccc acggccgcaa gcgcggcgac tgcgagcaat     1560

aacttcacgc gctgcctggt gggtgctggc gcgagtgccg ccattcagcc catgattgac     1620

ggggtgggca ctggatgggc ttttacgatt cttgcaggaa ttactatggt tgcgtctccg     1680

ctgactcttt ggacgttgtt gaagaagggc atggggtggc ggaaggagcg ggaggagaag     1740

aggaagcagc gggctgaggc tttggaaaag accaaacggg aggagactgc cccggaaagt     1800

ggagaaaaga acttgtga                                                   1818


<210>  316
<211>  605
<212>  PRT
<213>  Bipolaris maydis

<400>  316

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Thr His Ala Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Glu Asp Thr His Ser Asn Thr Glu 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Thr Asp Val Glu Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Ser Lys Val Glu Thr Gln Ser Lys Pro Phe Ser Ile Phe Thr His Arg 
65                  70                  75                  80  


Gln Lys Leu Gly Ile Val Met Ala Ser Ala Ala Ala Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Val Tyr Leu Pro Ala Leu Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Ser Ala Ile Asn Leu Thr Val Thr Thr Tyr 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Tyr Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Leu Ala Gln Gly Val Val Ser Asp Ile Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Val Ser Tyr Met Ser Thr Pro Val Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Ala Gln Tyr Leu 
                245                 250                 255     


Gly Trp Arg Trp Ile Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Val Thr Trp Met Pro Glu Thr Cys Arg Gly Ile Val 
        275                 280                 285             


Gly Asp Gly Ser Val Arg Pro Gln His Ile Val His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Ala Thr Arg Ser Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Glu Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Val Thr Lys His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Leu Met Leu Leu Leu Gln Pro Asn Met Ala Phe Leu Leu Leu Tyr 
        355                 360                 365             


Ser Ser Leu Ile Phe Ala Asn Phe Tyr Cys Ile Met Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Ile Tyr His Leu Thr Asp Leu Gln Thr Gly Leu 
385                 390                 395                 400 


Ile Tyr Leu Pro Leu Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Leu Leu Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Val Gly Val Pro Ala Leu Ile Leu Ala Thr 
    450                 455                 460                 


Cys Val Val Leu Val Trp Gly Trp Val Leu His Ala Arg Thr His Leu 
465                 470                 475                 480 


Ala Val Pro Cys Val Met Leu Phe Leu Ala Gly Leu Gly Leu Thr Gly 
                485                 490                 495     


Phe Ser Asn Val Val Ser Thr Leu Ile Val Asp Met Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Ile Asp Gly Val Gly Thr 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Leu Ala Gly Ile Thr Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Trp Thr Leu Leu Lys Lys Gly Met Gly Trp Arg Lys Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Glu Ala Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  317
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  317

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Thr His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Ser Thr His Ala Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Glu Asp Thr His Ser Asn Thr Glu 
        35                  40                  45              


Asn Ala Ala Gln Gln Pro Ser Asp Val Glu Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Ser Lys Val Glu Thr Gln Ser Lys Pro Phe Ser Ile Phe Thr His Arg 
65                  70                  75                  80  


Gln Lys Leu Gly Ile Val Met Ala Ser Ala Ala Ala Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Val Tyr Leu Pro Ala Leu Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Ser Ala Ile Asn Leu Thr Val Thr Thr Tyr 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Tyr Met Ala Ala Asn Ile Gly Cys Ala Val Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Leu Ala Asn Gly Val Val Ser Asp Ile Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Val Ser Tyr Leu Ser Thr Pro Met Val Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Ala Gln Tyr Leu 
                245                 250                 255     


Gly Trp Arg Trp Ile Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Val Thr Trp Met Pro Asp Thr Cys Lys Gly Ile Val 
        275                 280                 285             


Gly Asp Gly Ser Val Arg Pro Gln His Val Val His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Leu Gly Lys Asp Val Leu Gly Thr Arg Ser Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Asp Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Val Thr Lys His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Leu Met Leu Leu Leu Gln Pro Asn Met Ala Phe Leu Leu Leu Tyr 
        355                 360                 365             


Ser Ser Val Ile Phe Ala Asn Phe Phe Cys Met Leu Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Ile Tyr His Leu Thr Glu Leu Gln Thr Gly Leu 
385                 390                 395                 400 


Ile Phe Leu Pro Leu Gly Leu Gly Thr Ile Val Gly Thr Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Leu Leu Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Val Gly Val Pro Ala Leu Ile Leu Ala Ser 
    450                 455                 460                 


Cys Val Val Leu Val Trp Gly Trp Val Ile His Ala Arg Thr His Val 
465                 470                 475                 480 


Ala Val Pro Cys Val Met Leu Phe Leu Ala Gly Leu Gly Leu Thr Gly 
                485                 490                 495     


Phe Ser Asn Val Leu Ser Thr Leu Leu Val Asp Met Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Ser Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Ile Asp Gly Val Gly Thr 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Leu Ala Gly Ile Thr Met Val Gly Ser Pro 
545                 550                 555                 560 


Leu Thr Ile Trp Thr Leu Leu Lys Lys Gly Met Gly Trp Arg Lys Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Glu Ala Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  318
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  318

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Thr His Ala Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Glu Asp Thr His Ser Asn Ser Glu 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Ser Asp Val Glu Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Ser Lys Val Glu Ser Gln Ser Lys Pro Phe Ser Ile Phe Thr His Lys 
65                  70                  75                  80  


Gln Lys Met Gly Leu Val Met Ala Ser Ala Ala Gly Ala Phe Phe Thr 
                85                  90                  95      


Pro Leu Thr Ala Ser Val Tyr Leu Pro Ala Leu Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Leu Ser Tyr Ser Ala Ile Asn Leu Thr Leu Thr Thr Tyr 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Tyr Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Leu Ala Gln Gly Val Val Thr Asp Ile Met Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Val Ser Tyr Met Ser Thr Pro Val Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Ala Gln Tyr Met 
                245                 250                 255     


Gly Trp Arg Trp Ile Phe Phe Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Val Thr Trp Ile Pro Glu Thr Cys Arg Gly Ile Met 
        275                 280                 285             


Gly Asp Gly Ser Val Arg Pro Gln His Ile Val His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Ala Thr Arg Ser Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Glu Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Val Thr Lys His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Leu Met Leu Leu Leu Gln Pro Asn Met Ala Phe Leu Leu Leu Tyr 
        355                 360                 365             


Ser Ser Leu Ile Phe Ala Asn Phe Phe Cys Ile Met Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Val Tyr His Leu Thr Asp Leu Gln Thr Gly Val 
385                 390                 395                 400 


Ile Tyr Met Pro Leu Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Leu Leu Gly 
            420                 425                 430         


Ile Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Leu Gly Val Pro Ala Leu Ile Leu Ala Thr 
    450                 455                 460                 


Cys Val Val Leu Val Trp Gly Phe Val Met His Ala Arg Ser His Ile 
465                 470                 475                 480 


Ala Val Pro Cys Val Met Leu Phe Leu Ala Gly Leu Gly Leu Thr Gly 
                485                 490                 495     


Phe Ser Asn Val Val Ser Thr Val Ile Val Asp Met Asn Pro Thr Gly 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Ser Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Leu Asp Gly Leu Gly Thr 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Leu Ala Gly Ile Thr Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Trp Thr Leu Leu Lys Lys Gly Met Gly Trp Arg Lys Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Glu Ala Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  319
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  319

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Thr His Gly Lys Thr Glu Pro Ser 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Glu Asp Thr His Ser Asn Ser Asp 
        35                  40                  45              


Asn Gly Ala Gln Gln Pro Thr Asp Val Glu Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Ser Lys Val Glu Thr Gln Ser Lys Pro Phe Ser Ile Trp Thr His Arg 
65                  70                  75                  80  


Gln Lys Leu Ala Ile Val Ile Ala Ser Ala Ala Ala Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Met Tyr Leu Pro Ala Met Pro Gly Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Thr Ala Ile Asn Leu Thr Ile Thr Thr Tyr 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Ile 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Phe Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Val Ala Gln Ala Val Val Ser Asp Ile Ile Ser Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Phe Ile Ser Tyr Val Ser Thr Pro Val Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Ala Gln Tyr Leu 
                245                 250                 255     


Gly Trp Arg Tyr Ile Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Leu Thr Phe Met Pro Glu Thr Cys Arg Gly Val Val 
        275                 280                 285             


Gly Asp Gly Ser Val Arg Pro Gln His Ile Val His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Leu Gly Lys Asp Val Leu Ala Thr Arg Ser Ser Arg Lys Gln Asn 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Asp Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Val Thr Lys His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Leu Met Leu Leu Leu Gln Pro Asn Met Ala Phe Leu Leu Leu Tyr 
        355                 360                 365             


Ser Ser Leu Leu Phe Ala Asn Phe Tyr Cys Ile Met Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Val Tyr His Leu Thr Asp Val Gln Ser Gly Leu 
385                 390                 395                 400 


Met Tyr Leu Pro Leu Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Leu Leu Gly 
            420                 425                 430         


Val Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Leu Gly Val Pro Ala Leu Ile Leu Ala Thr 
    450                 455                 460                 


Cys Val Leu Leu Val Trp Gly Trp Val Val His Ala Arg Ser His Leu 
465                 470                 475                 480 


Ala Ile Pro Cys Val Val Leu Phe Leu Ala Gly Leu Gly Leu Thr Gly 
                485                 490                 495     


Phe Ser Asn Val Val Ser Thr Leu Ile Met Asp Met Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Ile Asp Gly Val Gly Thr 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Val Ala Gly Ile Thr Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Trp Thr Leu Leu Arg Lys Gly Met Gly Trp Arg Lys Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Glu Ala Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  320
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  320

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Thr His Gly Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Asp Asp Thr His Ser Asn Thr Glu 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Thr Asp Val Glu Ala Arg Ala Asn Gly Val 
    50                  55                  60                  


Ser Lys Val Glu Thr Gln Ser Lys Pro Phe Ser Ile Phe Thr His Arg 
65                  70                  75                  80  


Gln Arg Leu Gly Leu Val Met Ala Ser Ala Ala Ala Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Val Tyr Leu Pro Ala Leu Pro Gly Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Ser Gly Leu Asn Leu Thr Leu Thr Thr Tyr 
        115                 120                 125             


Leu Val Thr Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Phe Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Leu Ala Gln Gly Val Val Ser Asp Ile Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Val Ser Tyr Leu Ser Thr Pro Val Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Gly Asn Tyr Leu 
                245                 250                 255     


Gly Trp Arg Trp Ile Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Val 
            260                 265                 270         


Thr Val Val Phe Val Thr Trp Met Pro Glu Thr Cys Arg Gly Ile Val 
        275                 280                 285             


Gly Asp Ala Ser Val Arg Pro Gln His Ile Val His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Leu Gly Lys Asp Val Leu Ala Thr Lys Ser Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Glu Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Val Thr Arg His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Val Met Ile Leu Leu Asn Pro Asn Met Ala Phe Leu Leu Leu Phe 
        355                 360                 365             


Ser Ser Leu Ile Phe Ala Asn Trp Tyr Cys Ile Met Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Ser Ser Ile Tyr His Leu Thr Asp Leu Gln Thr Gly Val 
385                 390                 395                 400 


Leu Tyr Leu Pro Ile Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Leu Leu Gly 
            420                 425                 430         


Val Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Val Gly Val Pro Ala Met Ile Leu Ala Thr 
    450                 455                 460                 


Cys Val Val Leu Val Phe Ala Trp Val Leu His Ala Arg Thr His Leu 
465                 470                 475                 480 


Ala Val Pro Cys Val Met Leu Phe Leu Ala Gly Leu Gly Val Thr Gly 
                485                 490                 495     


Phe Ser Asn Leu Leu Thr Ser Leu Ile Val Asp Met Asn Pro Ser Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Ile Asp Gly Val Gly Thr 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Met Ala Gly Ile Thr Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Trp Ser Ile Leu Lys Lys Gly Met Gly Trp Lys Lys Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Glu Ala Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  321
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  321

Met Ala Gln Pro Pro Asp Ser Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Ser His Ala Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Glu Gly Gly Leu Glu Asp Thr His Ser Asn Ser Asp 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Thr Asp Val Glu Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Thr Lys Val Glu Thr Gln Ser Lys Pro Phe Ser Ile Trp Ser His Arg 
65                  70                  75                  80  


Gln Lys Leu Gly Leu Val Val Ala Ser Ala Ala Ala Gly Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Val Tyr Leu Pro Ala Leu Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Ser Ala Ile Asn Ile Thr Leu Thr Thr Tyr 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Gly Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Trp Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Tyr Pro Gly Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Val Ala Asn Gly Val Val Ser Glu Leu Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Lys Tyr Val Ser Tyr Met Thr Thr Pro Ile Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Ala Thr Leu Ala Gln Tyr Leu 
                245                 250                 255     


Gly Trp Arg Trp Ile Phe Trp Ile Ile Thr Ile Met Cys Gly Thr Ile 
            260                 265                 270         


Thr Val Val Phe Val Thr Trp Met Pro Glu Ser Cys Arg Gly Leu Val 
        275                 280                 285             


Gly Asp Gly Ser Val Arg Pro Gln His Met Val His Arg Thr Met Phe 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Ala Thr Lys Ser Ser Arg Arg Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Glu Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Val Thr Lys His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Ile Met Leu Leu Leu Asn Pro Asn Met Ala Phe Met Leu Leu Tyr 
        355                 360                 365             


Ser Ser Met Ile Tyr Ala Asn Tyr Phe Cys Ile Met Ser Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Ile Phe His Leu Thr Asp Leu Gln Thr Gly Leu 
385                 390                 395                 400 


Ile Tyr Leu Pro Leu Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Leu Ile Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Gly Arg Leu Glu Val Gly Val Pro Ala Leu Ile Leu Ala Thr 
    450                 455                 460                 


Cys Val Val Leu Val Trp Gly Trp Val Met His Ala Arg Thr His Leu 
465                 470                 475                 480 


Ala Leu Pro Cys Val Met Leu Phe Leu Ala Gly Leu Gly Leu Thr Gly 
                485                 490                 495     


Phe Ser Asn Val Val Thr Thr Val Leu Val Glu Val Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Gln Phe Thr Arg Cys Leu Val Ala 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Ile Asp Ala Leu Gly Thr 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Leu Ala Gly Ile Thr Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Ile Tyr Thr Val Leu Lys Lys Gly Met Gly Trp Lys Lys Glu 
                565                 570                 575     


Lys Glu Glu Lys Arg Lys Gln Arg Ala Glu Ala Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  322
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  322

Met Ala Asn Pro Pro Asp Ser Val Arg Pro Gly Thr His Ile Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Ser His Ala Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Glu Asp Thr His Ser Gln Thr Asp 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Thr Asp Met Glu Ala Arg Ala Asn Ala Ile 
    50                  55                  60                  


Ser Lys Val Glu Thr Gln Ser Lys Pro Tyr Ser Ile Phe Ser His Lys 
65                  70                  75                  80  


Asn Lys Leu Gly Leu Val Val Ala Ser Ala Ala Ala Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Ile Tyr Leu Pro Ala Leu Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Ser Ala Val Asn Leu Thr Val Thr Thr Tyr 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Tyr Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Phe Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Leu Ala Gln Gly Val Val Ser Asp Ile Ile Ser Ser 
    210                 215                 220                 


Ala Glu Arg Gly Lys Tyr Val Ser Tyr Met Ser Thr Pro Leu Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Ala Gln Tyr Leu 
                245                 250                 255     


Gly Trp Arg Phe Leu Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Ile Thr Phe Met Pro Glu Thr Cys Arg Gly Ile Ile 
        275                 280                 285             


Gly Asp Gly Ser Ile Lys Pro Gln His Ile Val His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Leu Gly Lys Asp Val Leu Gly Thr Arg Ser Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Glu Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Gly Asn Gln Ala Val Thr Lys His Lys Phe Lys Ala Leu His 
            340                 345                 350         


Ala Leu Leu Leu Leu Leu Gln Pro Asn Met Ala Phe Met Leu Leu Tyr 
        355                 360                 365             


Ser Ser Leu Ile Trp Ala Asn Phe Trp Cys Ile Ile Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Thr Ile Tyr His Leu Thr Asp Val Gln Ser Gly Leu 
385                 390                 395                 400 


Ile Tyr Leu Pro Leu Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Arg Arg His Cys Asn Val Leu Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Lys Leu Glu Val Gly Val Pro Ala Leu Ile Leu Gly Thr 
    450                 455                 460                 


Cys Val Val Leu Val Trp Gly Trp Val Val His Ala Arg Ser His Leu 
465                 470                 475                 480 


Ala Leu Pro Cys Val Met Leu Phe Leu Ala Gly Leu Gly Val Thr Ala 
                485                 490                 495     


Phe Ser Asn Ile Val Ser Thr Ile Ile Val Asp Leu Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Ile Gln Pro Met Ile Asp Gly Leu Gly Thr 
    530                 535                 540                 


Ala Tyr Ala Phe Thr Val Leu Ala Gly Ile Thr Met Val Gly Ser Pro 
545                 550                 555                 560 


Leu Thr Val Trp Thr Leu Leu Arg Arg Gly Met Gly Trp Arg Lys Glu 
                565                 570                 575     


Arg Glu Glu Arg Lys Lys Gln Arg Ala Glu Gly Leu Glu Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Glu Ser Gly Glu Lys Asn Leu 
        595                 600                 605 


<210>  323
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  323

Met Ala Gln Pro Pro Asp Ser Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Thr His Ala Arg Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Leu Asp Asp Thr His Thr Asn Thr Glu 
        35                  40                  45              


Asn Ala Gly Gln Gln Pro Thr Glu Val Glu Ala Arg Ala Asn Ala Leu 
    50                  55                  60                  


Ser Lys Val Glu Thr Gln Ser Lys Pro Phe Ser Leu Phe Thr His Arg 
65                  70                  75                  80  


Gln Arg Leu Ala Val Val Met Ala Ser Ala Ala Ala Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Thr Met Tyr Leu Pro Ala Ile Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Val Ser Tyr Ser Gly Ile Asn Leu Thr Val Thr Thr Tyr 
        115                 120                 125             


Met Val Thr Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Gly Tyr Leu Phe Cys 
                165                 170                 175     


Phe Ile Val Tyr Met Ala Ala Asn Ile Gly Cys Ala Val Ala Pro Asn 
            180                 185                 190         


Tyr Pro Gly Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Ile Ala Met Ala Gln Gly Val Val Ser Asp Ile Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Val Ser Tyr Leu Ser Thr Pro Val Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Ala Gln Tyr Val 
                245                 250                 255     


Gly Trp Arg Trp Ile Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Leu Thr Phe Leu Pro Glu Ser Cys Lys Ala Leu Ile 
        275                 280                 285             


Gly Glu Gly Ser Val Arg Pro Asn His Leu Val His Lys Ser Ile Phe 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Gly Thr Lys Thr Ser Arg Arg Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Glu Asp Glu His Ser Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Ser Ala Asn Gln Ala Val Thr Lys His Lys Phe Arg Ala Ile His 
            340                 345                 350         


Ala Val Met Leu Leu Leu Gln Pro Asn Met Ala Phe Leu Leu Leu Tyr 
        355                 360                 365             


Ser Ser Leu Leu Tyr Ala Asn Phe Tyr Cys Val Leu Thr Thr Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Thr Ile Tyr His Val Thr Asp Leu Gln Thr Gly Leu 
385                 390                 395                 400 


Met Tyr Leu Pro Met Gly Leu Gly Thr Ile Val Gly Ser Gln Val Gly 
                405                 410                 415     


Gly Arg Ser Leu Asp Trp Asn Phe Lys Arg His Cys Asn Val Leu Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Leu 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Val Gly Val Pro Ala Leu Leu Leu Gly Thr 
    450                 455                 460                 


Cys Val Leu Leu Val Phe Gly Phe Leu Leu His Ala Arg Ser His Leu 
465                 470                 475                 480 


Ala Val Pro Cys Val Leu Leu Phe Leu Ala Gly Leu Gly Leu Thr Ala 
                485                 490                 495     


Phe Ser Asn Ile Leu Thr Thr Val Ile Val Asp Leu Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Ser Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Val Gln Pro Met Ile Asp Gly Val Gly Ser 
    530                 535                 540                 


Gly Trp Ala Phe Thr Ile Leu Ala Gly Leu Ser Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Phe Thr Ile Ile Lys Lys Gly Val Gly Trp Arg Arg Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Asp Gly Leu Glu Lys Ser Lys 
            580                 585                 590         


Arg Asp Glu Thr Ala Pro Glu Ser Gly Glu Lys Gln Leu 
        595                 600                 605 


<210>  324
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  324

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Glu Thr Ala Thr Ser His Ala Lys Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Ala Leu Glu Asp Ser His Ser Asn Thr Glu 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Ser Glu Ile Asp Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Ser Arg Val Glu Thr Gln Ser Lys Pro Tyr Ser Leu Trp Thr His Arg 
65                  70                  75                  80  


Gln Arg Leu Gly Leu Val Ile Ala Ser Ala Ala Ala Gly Phe Phe Ser 
                85                  90                  95      


Pro Leu Ser Ala Ser Met Tyr Val Pro Ala Val Pro Ala Ile Ala Lys 
            100                 105                 110         


Asp Phe Gly Leu Ser Tyr Ser Ala Leu Asn Leu Thr Leu Thr Thr Tyr 
        115                 120                 125             


Leu Val Thr Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Gly Asp Ser Ala Gly Arg Arg Pro Ala Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Phe Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Ser Thr Val Ala Leu Ala Gln Ala Val Val Ser Asp Ile Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Ile Ser Tyr Met Ser Thr Pro Leu Leu Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Ala Thr Leu Ala Gln Tyr Met 
                245                 250                 255     


Gly Trp Arg Trp Val Phe Trp Ile Leu Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Val Thr Trp Leu Pro Glu Ser Cys Arg Ala Leu Val 
        275                 280                 285             


Gly Asp Gly Ser Ile Arg Pro Gln His Met Leu His Arg Ser Leu Trp 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Gly Thr Arg Thr Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Asn Ser Asn Arg Gln Asp Glu Asp His Thr Ala Thr Gly Pro Lys 
                325                 330                 335     


Pro Ser Gly Gln Gln Ala Leu Thr Lys His Arg Phe Lys Ala Ile His 
            340                 345                 350         


Gly Leu Leu Val Leu Leu Gln Pro Asn Met Ala Phe Ile Ile Leu Phe 
        355                 360                 365             


Ser Ser Leu Ile Phe Ala Asn Phe Tyr Cys Val Ile Thr Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Ile Phe His Leu Thr Asp Leu Asn Thr Gly Leu 
385                 390                 395                 400 


Val Tyr Leu Pro Val Gly Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Val Asp Trp Asn Phe Arg Arg His Cys Asn Leu Met Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Leu 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Val Ala Ile Pro Ala Met Met Leu Ala Thr 
    450                 455                 460                 


Cys Val Val Leu Val Trp Ala Trp Val Leu His Ala Arg Thr His Leu 
465                 470                 475                 480 


Ala Val Pro Cys Val Leu Leu Phe Leu Ala Gly Leu Gly Met Ser Gly 
                485                 490                 495     


Phe Thr Asn Met Leu Ser Thr Leu Ile Val Glu Met Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Val Gln Pro Met Ile Asp Gly Val Gly Thr 
    530                 535                 540                 


Gly Trp Ala Trp Thr Ile Ile Ala Gly Ile Thr Met Val Ala Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Tyr Thr Leu Leu Lys Lys Gly Met Gly Trp Lys Lys Glu 
                565                 570                 575     


Arg Glu Glu Lys Arg Lys Gln Arg Ala Asp Ala Val Glu Arg Ser Lys 
            580                 585                 590         


Arg Glu Glu Thr Ala Pro Asp Ser Ala Asp Lys Asn Leu 
        595                 600                 605 


<210>  325
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  325

Met Ala Gln Pro Pro Asp Thr Met Arg Pro Ala Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Thr His Ala Arg Thr Glu Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Glu Gly Gly Met Glu Glu Thr His Thr Asn Ser Asp 
        35                  40                  45              


Asn Gly Gly Gln Gln Pro Thr Asp Leu Asp Ala Arg Ala Asn Ala Val 
    50                  55                  60                  


Ser Arg Leu Glu Thr Gln Ser Lys Pro Phe Thr Ile Trp Thr His Lys 
65                  70                  75                  80  


Gln Arg Leu Gly Met Val Met Ala Ser Gly Ala Gly Ala Phe Phe Thr 
                85                  90                  95      


Pro Leu Thr Ala Thr Val Trp Leu Pro Ala Leu Pro Ala Ile Ala Lys 
            100                 105                 110         


Glu Phe Gly Ile Ser Tyr Ser Ala Val Asn Ile Thr Val Thr Thr Phe 
        115                 120                 125             


Met Val Ser Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Gly Tyr Met Phe Cys 
                165                 170                 175     


Phe Ile Val Tyr Met Ala Ala Asn Ile Gly Cys Ala Leu Ala Pro Asn 
            180                 185                 190         


Trp Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Met Ala Ile Gly Gln Gly Val Val Thr Glu Met Ile Thr Ser 
    210                 215                 220                 


Ala Glu Arg Gly Arg Tyr Met Ser Tyr Met Ser Thr Pro Ile Val Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Gly Gln Tyr Val 
                245                 250                 255     


Gly Trp Arg Tyr Leu Phe Tyr Ile Val Thr Ile Met Cys Gly Thr Val 
            260                 265                 270         


Thr Val Val Phe Leu Thr Phe Ile Pro Glu Thr Cys Lys Gly Leu Val 
        275                 280                 285             


Gly Glu Ala Ser Val Arg Pro Gln His Ile Val His Arg Thr Leu Trp 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Ala Thr Lys Ser Ser Arg Lys Gln Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Asp Glu Glu His Thr Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Thr Gly Gln Gln Ala Val Thr Lys His Lys Phe Arg Gly Leu His 
            340                 345                 350         


Ala Val Ile Val Leu Leu Gln Pro Gln Met Ala Phe Ile Val Leu Phe 
        355                 360                 365             


Ser Ser Leu Val Trp Ala Asn Tyr Tyr Cys Leu Leu Thr Thr Ile Pro 
    370                 375                 380                 


Ala Gln Phe Ser Ser Leu Tyr His Met Thr Asp Leu Asn Ser Gly Ile 
385                 390                 395                 400 


Ile Tyr Ile Pro Val Ala Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Met Asp Trp Asn Phe Arg Arg His Cys Asn Leu Ile Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Phe Pro Ile 
        435                 440                 445             


Glu Arg Ala Arg Leu Glu Leu Gly Ile Pro Gly Ile Val Leu Ala Thr 
    450                 455                 460                 


Cys Val Leu Leu Val Tyr Ala Trp Val Leu His Ala Arg Thr His Ile 
465                 470                 475                 480 


Ala Ile Pro Cys Val Leu Leu Phe Leu Gly Gly Leu Gly Leu Thr Gly 
                485                 490                 495     


Phe Ser Asn Ile Val Thr Ser Leu Val Val Asp Met Asn Pro Thr Ala 
            500                 505                 510         


Ala Ser Ala Ala Thr Ala Ser Asn Asn Phe Thr Arg Cys Leu Val Ala 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Met Gln Pro Met Ile Asp Gly Leu Gly Thr 
    530                 535                 540                 


Gly Trp Ala Tyr Thr Val Leu Ala Gly Leu Thr Met Val Ala Thr Pro 
545                 550                 555                 560 


Leu Thr Ile Trp Thr Leu Ile Lys Lys Ala Met Gly Phe Lys Lys Glu 
                565                 570                 575     


Arg Asp Glu Lys Lys Lys Gln Arg Ala Asp Ala Met Asp Lys Ser Arg 
            580                 585                 590         


Lys Glu Glu Ser Ala Pro Glu Ser Gly Glu Lys Gln Leu 
        595                 600                 605 


<210>  326
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 316

<400>  326

Met Ala Gln Pro Pro Asp Thr Val Arg Pro Gly Ser His Leu Val Pro 
1               5                   10                  15      


Arg Ala Ser Ile Asp Ser Ala Thr Ser His Ala Arg Thr Asp Pro Thr 
            20                  25                  30          


Pro Pro Pro Pro Asp Gly Gly Val Glu Asp Thr His Ser Asn Ser Glu 
        35                  40                  45              


Asn Gly Ala Gln Gln Pro Thr Glu Val Glu Ala Lys Ala Asn Gly Leu 
    50                  55                  60                  


Ser Lys Val Glu Ser Gln Thr Lys Pro Phe Ser Ile Phe Thr His Lys 
65                  70                  75                  80  


Gln Arg Leu Gly Val Val Met Ala Ser Ala Ala Gly Ala Phe Phe Ser 
                85                  90                  95      


Pro Leu Thr Ala Ser Met Phe Leu Pro Ala Ile Pro Ala Ile Ala Arg 
            100                 105                 110         


Glu Phe Gly Ile Ser Tyr Ser Ala Val Asn Leu Thr Leu Thr Thr Tyr 
        115                 120                 125             


Met Val Thr Thr Gly Leu Leu Cys Ser Lys Ile His Thr Ser Pro Leu 
    130                 135                 140                 


Leu Thr His Arg Pro Lys Ile Phe Gln Gly Ile Thr Pro Met Phe Val 
145                 150                 155                 160 


Gly Ala Tyr Ala Asp Ser Ala Gly Arg Arg Pro Ala Tyr Leu Phe Cys 
                165                 170                 175     


Phe Ile Val Phe Met Ala Ala Asn Ile Gly Cys Ala Val Ala Pro Asn 
            180                 185                 190         


Tyr Pro Ala Leu Leu Val Leu Arg Met Leu Gln Ser Ala Gly Ser Ser 
        195                 200                 205             


Thr Thr Val Ala Leu Ala Gln Gly Val Val Ser Asp Leu Ile Thr Ser 
    210                 215                 220                 


Gly Glu Arg Gly Arg Tyr Leu Ser Tyr Met Ser Thr Pro Leu Met Leu 
225                 230                 235                 240 


Gly Pro Ser Leu Gly Pro Val Leu Gly Gly Thr Leu Gly Asn Tyr Leu 
                245                 250                 255     


Gly Trp Arg Tyr Ile Phe Trp Ile Ile Thr Ile Met Cys Gly Thr Leu 
            260                 265                 270         


Thr Val Val Phe Leu Thr Tyr Leu Pro Asp Ser Cys Arg Gly Ile Ile 
        275                 280                 285             


Gly Asp Ala Ser Ile Arg Pro Gln His Val Leu His Arg Thr Ile Trp 
    290                 295                 300                 


Arg Val Gly Lys Asp Val Leu Ala Thr Arg Ser Ser Arg Arg Asn Gln 
305                 310                 315                 320 


Ala Gln Thr Asn Arg Gln Glu Glu Glu His Thr Ala Thr Gly Pro Arg 
                325                 330                 335     


Pro Thr Ala Gln Gln Ala Ile Thr Lys His Arg Phe Lys Ala Val His 
            340                 345                 350         


Ala Leu Met Met Leu Leu Gln Pro Asn Met Ala Phe Leu Val Leu Tyr 
        355                 360                 365             


Ser Ser Leu Val Phe Ala Asn Tyr Phe Cys Ile Leu Ser Ser Ile Pro 
    370                 375                 380                 


Ala Gln Phe Thr Ser Ile Phe His Leu Thr Asp Val Asn Thr Gly Ile 
385                 390                 395                 400 


Val Tyr Ile Pro Val Ala Leu Gly Thr Ile Val Gly Ser Gln Val Ala 
                405                 410                 415     


Gly Arg Ser Ile Asp Trp Asn Phe Arg Arg His Cys Gln Val Val Gly 
            420                 425                 430         


Leu Pro Tyr Glu Arg Lys Arg Gln Gln Asp Leu Ser Ser Trp Pro Val 
        435                 440                 445             


Glu Arg Gly Arg Leu Glu Ile Ala Leu Pro Ala Leu Ile Leu Ala Ser 
    450                 455                 460                 


Cys Val Leu Leu Val Phe Ala Phe Leu Leu His Ala Arg Thr His Val 
465                 470                 475                 480 


Ala Val Pro Cys Val Leu Leu Phe Leu Ala Gly Leu Gly Val Thr Gly 
                485                 490                 495     


Phe Ser Asn Val Leu Ser Ser Leu Ile Val Glu Val Asn Pro Ser Ala 
            500                 505                 510         


Ala Ser Ala Ala Ser Ala Ser Asn Asn Phe Ser Arg Cys Leu Val Gly 
        515                 520                 525             


Ala Gly Ala Ser Ala Ala Leu Gln Pro Met Leu Asp Gly Val Gly Thr 
    530                 535                 540                 


Gly Trp Ala Tyr Thr Val Met Ala Gly Ile Thr Met Val Gly Ser Pro 
545                 550                 555                 560 


Leu Thr Leu Trp Thr Val Leu Arg Arg Ala Val Ala Tyr Lys Arg Glu 
                565                 570                 575     


Lys Asp Glu Lys Lys Lys Gln Arg Ala Glu Gly Leu Asp Lys Thr Lys 
            580                 585                 590         


Arg Glu Glu Ser Ala Pro Glu Ser Gly Glu Arg Asn Leu 
        595                 600                 605 


<210>  327
<211>  1593
<212>  DNA
<213>  Bipolaris maydis

<400>  327
atggcagcta atcctgacac cgaagggcaa gcgactgaga ctacttctct cctcagccga       60

aagtccacac aggcgcgcta ctccgtgttt accactactc aaaaacgaat cttgatctcc      120

acagcctcac tggcctcgac actctcgccc ttatcagcaa atatctatta cccagtgctg      180

aattctatgg caaaagatct ccacgtcagc cacgcaatga tgaacttcac tatcatgggc      240

tatatggtac gtaatttcca tggcaatgat tcacatttca gaactaattt ctaaaatcaa      300

gctgttacaa gcttttgcgc cgacaatcgc tggttccatc gctgatgtcg ttggccggcg      360

acctgtctac atcttttgct tcctcatcta catcgcttct gatgtagctc ttgctctgca      420

gagaactttc cctgctcttg ttattcttcg agctgttcaa agttccggta gcagcccaat      480

ggtcgcactt gcgagtgctg ttgcggcaga tatagtaact tctgctgaaa gaggcatgta      540

ccttgggatc gcatcacttg gctctgcgct cgctccttcc ctcggcccaa tcataggtgg      600

aatacttagc cattggttcg gttggccatc tatattctgg tttctagcaa ttgtggctac      660

gtttttcttt gtgccattct tgctattctt tccagaaact tgcagaacaa tcgtcaaaga      720

tggatccgta cagccgctgg ggttcaatca aacagtatat caatggatga aacaaaagtc      780

gaaacagcgt aatggagaag aagaatcaga aggagatttg acgtactcag gaaaaacacg      840

catcagtcta cccgatcctc ttgtcactct tcgagtcgtg tttcagttcc ctacgggaat      900

tgtcatgctg ggtaatggca ttcttttcgc gagctactat gctgtcatgt ctagtgttcc      960

gtcacagttc gaaatcttat atggattcaa tgacctccaa atcggtttag cctttatacc     1020

cgcaggatta ggaaccctat tcagtgcttt cacaaacggt ataattgtcg actggaacta     1080

ccgacgcgta gaagccgccc tgaaagagag atctgatcac gagcggagta caaaagagaa     1140

ttttcctttc gaaaagacac ggctgcacat agctttgcct atgatggtaa gaaaccttag     1200

ctacttgcct tgcactctat tagtaacacg agaaagatct tagcagctat atcgatcggt     1260

atttacggtt gggtaatttt tttccgcagc ccaatctggg ctcctttggc attgctgttt     1320

cttattgcct tttcagtcac tggggcctac aacgtcatga acattttggt cgtcgatctc     1380

aattattcga ggcctgcgac ggctatggcg gctaataact tggtaaggtg tacacttggg     1440

gcagctgcca cagttctcat tcaccctttg ctcaactggg tcggcagagg atggagtttt     1500

acctgtattg ctggggctat tatagcagcc actccactac tcctagtctc ctacagatgg     1560

ggacttgcat ggagagcatc ttcaaataaa tga                                  1593


<210>  328
<211>  495
<212>  PRT
<213>  Bipolaris maydis

<400>  328

Met Ala Ala Asn Pro Asp Thr Glu Gly Gln Ala Thr Glu Thr Thr Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Arg Tyr Ser Val Phe Thr Thr 
            20                  25                  30          


Thr Gln Lys Arg Ile Leu Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Ile Tyr Tyr Pro Val Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Val Ser His Ala Met Met Asn Phe Thr Ile Met Gly 
65                  70                  75                  80  


Tyr Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Val Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Met Val Ala 
    130                 135                 140                 


Leu Ala Ser Ala Val Ala Ala Asp Ile Val Thr Ser Ala Glu Arg Gly 
145                 150                 155                 160 


Met Tyr Leu Gly Ile Ala Ser Leu Gly Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Ile Leu Ser His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Ile Phe Trp Phe Leu Ala Ile Val Ala Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Thr Cys Arg Thr Ile Val Lys Asp Gly Ser 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Thr Val Tyr Gln Trp Met Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Asn Gly Glu Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Thr Arg Ile Ser Leu Pro Asp Pro Leu Val Thr Leu 
            260                 265                 270         


Arg Val Val Phe Gln Phe Pro Thr Gly Ile Val Met Leu Gly Asn Gly 
        275                 280                 285             


Ile Leu Phe Ala Ser Tyr Tyr Ala Val Met Ser Ser Val Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Leu Tyr Gly Phe Asn Asp Leu Gln Ile Gly Leu Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Arg Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Ile Ala Leu Pro Met Met Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Gly Trp Val Ile Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Leu Ala Leu Leu Phe Leu Ile Ala Phe Ser Val Thr Gly Ala Tyr Asn 
                405                 410                 415     


Val Met Asn Ile Leu Val Val Asp Leu Asn Tyr Ser Arg Pro Ala Thr 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Leu Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Val Leu Ile His Pro Leu Leu Asn Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Leu Leu Leu 
465                 470                 475                 480 


Val Ser Tyr Arg Trp Gly Leu Ala Trp Arg Ala Ser Ser Asn Lys 
                485                 490                 495 


<210>  329
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  329

Met Ala Ala Asn Pro Asp Thr Glu Gly Gln Ala Ser Glu Thr Thr Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Arg Tyr Ser Val Phe Thr Thr 
            20                  25                  30          


Ser Gln Lys Arg Ile Leu Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Ile Tyr Tyr Pro Val Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Val Ser His Ala Met Met Asn Phe Thr Ile Met Gly 
65                  70                  75                  80  


Phe Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Ile Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Val Ala Leu Gln Arg Ser Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Leu Val Ala 
    130                 135                 140                 


Leu Ala Ser Ala Val Ala Ala Asp Leu Val Thr Ser Ala Asp Arg Gly 
145                 150                 155                 160 


Met Tyr Val Gly Ile Ala Ser Leu Gly Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Ile Leu Ser His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Val Phe Trp Phe Leu Ala Ile Leu Ala Thr Phe Tyr Phe Val Pro Phe 
        195                 200                 205             


Ile Leu Phe Phe Pro Asp Thr Cys Arg Thr Ile Val Lys Asp Gly Ser 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Ser Val Tyr Gln Trp Met Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Gln Gly Glu Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Thr Arg Ile Ser Leu Pro Asp Pro Leu Val Thr Leu 
            260                 265                 270         


Arg Val Val Phe Gln Phe Pro Thr Gly Ile Val Met Leu Gly Asn Gly 
        275                 280                 285             


Ile Leu Phe Ala Ser Tyr Tyr Ala Ile Met Ser Ser Leu Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Ile Tyr Gly Phe Asn Asp Leu Gln Ile Gly Leu Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Arg Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Met Ala Leu Pro Met Met Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Gly Trp Val Ile Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Leu Ala Leu Leu Phe Leu Ile Ala Phe Ser Val Thr Gly Ala Tyr Asn 
                405                 410                 415     


Val Met Asn Ile Leu Val Val Asp Leu Asn Tyr Ser Arg Pro Ala Ser 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Met Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Val Leu Ile His Pro Leu Leu Gln Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Leu Leu Ile 
465                 470                 475                 480 


Val Ser Tyr Arg Trp Gly Leu Ala Trp Arg Ala Ser Ser Asn Lys 
                485                 490                 495 


<210>  330
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  330

Met Ala Gly Asn Pro Asp Thr Glu Gly Gln Ala Thr Glu Thr Thr Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Arg Tyr Ser Val Phe Ser Thr 
            20                  25                  30          


Thr Gln Lys Arg Ile Leu Ile Ser Thr Ala Ser Leu Gly Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Ile Tyr Tyr Pro Val Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Leu Ser His Ala Met Met Asn Phe Thr Ile Met Gly 
65                  70                  75                  80  


Tyr Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Ile Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Met Val Ala 
    130                 135                 140                 


Val Ala Ser Ala Val Ala Ala Asp Ile Val Thr Thr Ala Glu Arg Gly 
145                 150                 155                 160 


Met Tyr Ile Gly Ile Ala Ser Leu Gly Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Ile Leu Ser His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Leu Phe Trp Phe Leu Ala Ile Val Ala Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Thr Cys Arg Thr Leu Val Lys Asp Gly Ser 
    210                 215                 220                 


Val Asn Pro Leu Gly Phe Asn Gln Ser Val Tyr Gln Trp Met Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Asn Gly Glu Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Ser Lys Ile Ser Leu Pro Asp Pro Leu Leu Thr Leu 
            260                 265                 270         


Arg Val Val Phe Gln Phe Pro Thr Gly Ile Val Met Leu Gly Asn Gly 
        275                 280                 285             


Ile Leu Phe Ala Ser Tyr Tyr Ala Val Met Ser Ser Val Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Leu Tyr Gly Phe Asn Asp Leu Gln Ile Gly Val Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Ile Asp Trp Asn Tyr Arg Arg Leu Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Ile Ala Leu Pro Met Ile Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Gly Trp Val Ile Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Leu Ala Leu Leu Phe Leu Ile Ala Phe Ser Val Thr Gly Ala Tyr Asn 
                405                 410                 415     


Val Met Asn Ile Leu Val Val Glu Leu Asn Tyr Ser Arg Pro Ala Thr 
            420                 425                 430         


Ala Met Ala Ala Gln Asn Leu Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Leu Leu Ile His Pro Leu Leu Asn Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Leu Ile Val 
465                 470                 475                 480 


Ile Ser Tyr Arg Trp Gly Leu Ala Trp Arg Ala Ser Ser Asn Lys 
                485                 490                 495 


<210>  331
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  331

Met Ala Ala Asn Pro Asp Thr Glu Gly Gln Ala Thr Asp Thr Thr Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Lys Tyr Ser Val Phe Thr Ser 
            20                  25                  30          


Thr Gln Lys Arg Leu Leu Ile Ser Ser Ala Ser Leu Gly Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Ile Tyr Tyr Pro Val Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Glu Leu His Val Ser His Ala Met Met Asn Phe Thr Ile Met Gly 
65                  70                  75                  80  


Tyr Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Met Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Met Val Ala 
    130                 135                 140                 


Leu Ala Ser Ala Val Ala Ala Asp Ile Val Thr Ser Ala Glu Arg Gly 
145                 150                 155                 160 


Met Trp Met Gly Ile Ala Ser Leu Gly Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Val Leu Ser His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Ile Phe Trp Phe Ile Ala Ile Val Ala Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Ser Cys Arg Thr Ile Val Lys Asp Gly Ser 
    210                 215                 220                 


Val Asn Pro Leu Gly Phe Asn Gln Thr Val Tyr Gln Trp Met Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Asn Gly Glu Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Thr Arg Ile Ser Leu Pro Glu Pro Leu Leu Thr Leu 
            260                 265                 270         


Arg Val Val Phe Gln Phe Pro Thr Gly Ile Leu Met Leu Ala Asn Gly 
        275                 280                 285             


Leu Leu Phe Ala Ser Tyr Tyr Ala Val Met Thr Ser Val Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Leu Tyr Gly Phe Asn Asp Leu Gln Ile Gly Leu Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Lys Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Tyr Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Ile Ala Ile Pro Met Met Ile Leu Ala Ala Ile Ser Leu 
    370                 375                 380                 


Gly Ile Tyr Gly Trp Val Ile Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Leu Ala Leu Leu Phe Leu Ile Ala Phe Ser Leu Thr Gly Ala Phe Asn 
                405                 410                 415     


Leu Met Asn Ile Leu Val Val Asp Leu Asn Tyr Ser Arg Pro Ala Thr 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Val Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Met Leu Ile His Pro Leu Leu Gln Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Leu Ile Ala Ala Thr Pro Val Leu Val 
465                 470                 475                 480 


Val Ser Tyr Arg Trp Gly Val Ala Trp Arg Ala Ser Ser Asn Arg 
                485                 490                 495 


<210>  332
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  332

Met Ala Ala Asn Pro Asp Thr Glu Gly Gln Ala Thr Glu Thr Thr Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Arg Tyr Ser Val Phe Thr Thr 
            20                  25                  30          


Thr Gln Lys Arg Ile Leu Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Ile Tyr Tyr Pro Val Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Ile Ser His Ala Met Val Asn Phe Thr Leu Met Gly 
65                  70                  75                  80  


Phe Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Val Tyr Leu Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Met Val Ala 
    130                 135                 140                 


Leu Ala Ser Ala Val Ala Ala Asp Ile Val Thr Ser Ala Glu Arg Gly 
145                 150                 155                 160 


Leu Tyr Leu Gly Ile Ala Ser Leu Ala Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Ile Leu Ser His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Leu Phe Trp Phe Leu Ala Ile Leu Gly Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Thr Cys Arg Thr Ile Leu Lys Asp Gly Ser 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Thr Val Tyr Gln Trp Ile Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Gln Gly Glu Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Thr Arg Ile Ser Leu Pro Asp Pro Val Val Thr Leu 
            260                 265                 270         


Arg Val Val Phe Gln Phe Pro Thr Gly Val Val Met Leu Gly Asn Gly 
        275                 280                 285             


Ile Leu Phe Ala Thr Tyr Tyr Ala Val Ile Ser Ser Val Pro Thr Gln 
    290                 295                 300                 


Phe Glu Ile Leu Tyr Gly Phe Asn Asp Ile Gln Val Gly Leu Ala Phe 
305                 310                 315                 320 


Ile Pro Gly Gly Leu Gly Ser Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Arg Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Tyr Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Ile Ala Leu Pro Met Met Ile Leu Ala Ala Ile Ser Met 
    370                 375                 380                 


Gly Ile Tyr Gly Trp Leu Ile Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Leu Ala Leu Met Phe Leu Ile Ala Phe Ser Ile Thr Gly Ala Phe Asn 
                405                 410                 415     


Leu Ile Asn Val Leu Val Val Asp Leu Asn Tyr Thr Arg Pro Ala Ser 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Leu Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Val Leu Ile His Pro Leu Leu Asn Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Met Leu Ile 
465                 470                 475                 480 


Val Ser Tyr Arg Trp Gly Leu Ala Trp Arg Ala Ser Ser Asn Lys 
                485                 490                 495 


<210>  333
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  333

Met Ala Gly Asn Pro Asp Thr Glu Gly Gln Ala Thr Glu Thr Thr Ser 
1               5                   10                  15      


Leu Leu Thr Arg Lys Ser Thr Gln Gly Arg Tyr Ser Val Phe Thr Thr 
            20                  25                  30          


Thr Gln Lys Arg Ile Leu Ile Ser Ser Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Thr Ala Asn Ile Tyr Tyr Pro Ile Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Val Ser His Ala Met Met Asn Phe Thr Leu Met Gly 
65                  70                  75                  80  


Tyr Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Thr Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Val Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Thr Ser Pro Met Met Ala 
    130                 135                 140                 


Ile Ala Ser Ala Val Ala Gly Asp Ile Val Thr Ser Ala Glu Arg Gly 
145                 150                 155                 160 


Met Tyr Leu Gly Leu Ala Ser Ile Gly Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Leu Ile Gly Gly Ile Leu Thr His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Met Phe Trp Phe Met Ala Ile Val Ala Thr Phe Phe Tyr Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Thr Cys Arg Thr Leu Val Lys Asp Gly Ser 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Thr Val Tyr Gln Trp Met Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Asn Gly Glu Glu Glu Thr Asp Gly Asp Leu Thr 
                245                 250                 255     


Trp Ser Gly Lys Thr Arg Ile Ser Leu Pro Asp Pro Val Ile Thr Leu 
            260                 265                 270         


Arg Val Val Phe Gln Trp Pro Thr Gly Ile Val Met Leu Gly Asn Gly 
        275                 280                 285             


Leu Leu Trp Ala Ser Tyr Phe Ala Ile Met Ser Ser Leu Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Leu Phe Gly Phe Asn Asp Leu Gln Ile Gly Val Gly Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Arg Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Ile Ala Leu Pro Met Met Leu Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Gly Phe Val Ile Phe Phe Arg Thr Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Met Ala Leu Leu Phe Leu Ile Ala Phe Ser Val Thr Gly Ala Tyr Asn 
                405                 410                 415     


Val Met Asn Ile Leu Leu Val Glu Leu Asn Tyr Ser Lys Pro Ala Thr 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Val Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Val Leu Met His Pro Leu Leu Asn Tyr Val Gly Arg Ala Phe Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Leu Met Leu 
465                 470                 475                 480 


Leu Ser Tyr Lys Trp Gly Leu Ala Trp Arg Ala Ser Ser Asn Arg 
                485                 490                 495 


<210>  334
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  334

Met Ala Ala Asn Pro Glu Thr Glu Gly Gln Ala Thr Glu Thr Ser Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Arg Tyr Thr Val Phe Thr Thr 
            20                  25                  30          


Thr Gln Lys Arg Ile Val Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Ile Ser Ala Asn Val Tyr Tyr Pro Val Leu Asn Thr Met Ala 
    50                  55                  60                  


Lys Asp Leu His Val Ser His Ala Met Met Asn Trp Thr Ile Met Gly 
65                  70                  75                  80  


Tyr Leu Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Met Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Leu Val Ala 
    130                 135                 140                 


Leu Gly Ser Ala Val Ala Ala Asp Ile Val Thr Ser Ala Asp Arg Gly 
145                 150                 155                 160 


Met Tyr Leu Gly Leu Ala Thr Leu Gly Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Val Ile Gly Gly Ile Leu Ser His Phe Phe Gly Trp Pro Ser 
            180                 185                 190         


Ile Phe Trp Phe Leu Ala Ile Val Ala Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Ser Cys Lys Thr Ile Val Arg Glu Gly Ser 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Ser Val Tyr Gln Tyr Met Lys Gln 
225                 230                 235                 240 


Lys Ser Lys Gln Arg Asn Gly Glu Glu Glu Thr Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Thr Lys Ile Ser Leu Pro Asp Pro Leu Val Thr Leu 
            260                 265                 270         


Arg Val Val Phe Asn Phe Pro Thr Gly Ile Val Met Leu Gly Asn Gly 
        275                 280                 285             


Ile Val Phe Ala Ser Tyr Tyr Ala Val Ile Ser Ser Val Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Leu Tyr Gly Phe Asn Asp Val Gln Ile Gly Leu Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Ser Leu Phe Ser Gly Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Arg Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Ile Gly Val Pro Leu Met Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Ala Phe Leu Met Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Leu Ala Leu Leu Phe Leu Met Ala Phe Ser Val Ser Gly Ala Tyr Asn 
                405                 410                 415     


Val Met Asn Ile Leu Val Val Asp Val Asn Tyr Ser Arg Pro Ala Thr 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Leu Val Arg Cys Thr Leu Gly Gly Ala Ala 
        435                 440                 445             


Thr Val Leu Val His Pro Leu Leu Asn Phe Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Ser Pro Leu Leu Leu 
465                 470                 475                 480 


Leu Ser Tyr Arg Trp Gly Val Ala Tyr Lys Ala Ser Ser Asn Arg 
                485                 490                 495 


<210>  335
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  335

Met Ala Ala Asn Pro Asp Thr Glu Gly Gln Ala Thr Glu Thr Thr Ser 
1               5                   10                  15      


Ile Leu Ser Arg Lys Ser Thr Gln Ala Lys Tyr Ser Val Trp Ser Ser 
            20                  25                  30          


Ser Gln Arg Arg Leu Ile Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Ile Tyr Tyr Pro Val Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Glu Leu His Leu Ser His Ala Met Val Asn Phe Thr Leu Met Gly 
65                  70                  75                  80  


Tyr Leu Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Ile Gly Arg Arg Pro Leu Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Val Val Ala 
    130                 135                 140                 


Leu Ala Ser Ala Val Ala Ala Asp Leu Val Thr Ser Ala Asp Arg Gly 
145                 150                 155                 160 


Val Tyr Val Gly Leu Ala Thr Leu Ala Ser Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Leu Ile Gly Gly Ile Leu Ser His Trp Phe Gly Trp Pro Ser 
            180                 185                 190         


Ile Phe Tyr Phe Leu Ala Ile Val Ala Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Val Leu Phe Phe Pro Glu Thr Cys Arg Thr Val Val Arg Glu Ala Ser 
    210                 215                 220                 


Val Gln Pro Leu Ala Phe Asn Gln Thr Leu Tyr Gln Trp Met Arg Asn 
225                 230                 235                 240 


Lys Thr Lys Gln Arg Asn Gly Glu Glu Glu Ser Glu Ala Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Thr Arg Leu Ser Leu Pro Asp Pro Leu Val Thr Leu 
            260                 265                 270         


Arg Met Leu Phe Asn Phe Pro Thr Gly Ile Leu Leu Leu Ala Asn Gly 
        275                 280                 285             


Ile Met Phe Ala Ser Trp Tyr Gly Val Met Thr Ser Ile Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Val Trp Gly Phe Asn Glu Leu Gln Ile Gly Leu Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Val 
                325                 330                 335     


Ile Leu Asp Trp Asn Tyr Arg Lys Leu Glu Ala Ala Val Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Tyr Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Val Ala Ile Pro Met Leu Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Gly Trp Met Met Phe Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Ile Ala Leu Leu Phe Leu Met Ala Phe Ser Val Thr Gly Ala Trp Asn 
                405                 410                 415     


Ile Met Asn Ile Leu Val Val Asp Val Asn Tyr Ser Arg Pro Ala Ser 
            420                 425                 430         


Ala Val Ala Ala Asn Asn Leu Val Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Leu Leu Val His Pro Leu Val Asn Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Leu Leu Leu 
465                 470                 475                 480 


Leu Ser Tyr Arg Trp Gly Met Ala Trp Arg Ala Ser Ser Asn Lys 
                485                 490                 495 


<210>  336
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  336

Met Ala Ala Asn Pro Asp Ser Glu Gly Gln Ala Thr Glu Thr Thr Ser 
1               5                   10                  15      


Leu Leu Ser Arg Lys Ser Thr Gln Ala Arg Tyr Ser Leu Phe Thr Thr 
            20                  25                  30          


Thr Gln Arg Arg Leu Val Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Ser Pro Ile Ser Ala Gln Leu Tyr Tyr Pro Val Met Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Ile Ser His Ala Met Met Asn Phe Thr Ile Met Gly 
65                  70                  75                  80  


Phe Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Ile Gly Arg Arg Pro Met Tyr Leu Phe Cys Tyr Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Ile Ala Leu Gln Arg Thr Tyr Pro Gly Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Asn Ser Ser Gly Ser Ser Pro Ile Leu Ala 
    130                 135                 140                 


Leu Ala Ser Gly Leu Ala Ala Asp Leu Val Thr Ser Ala Glu Arg Gly 
145                 150                 155                 160 


Met Tyr Leu Gly Val Ala Ser Leu Gly Ser Gly Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Leu Leu Ser His Trp Phe Gly Trp Pro Thr 
            180                 185                 190         


Ile Phe Trp Phe Leu Ala Ile Val Gly Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Val Phe Phe Pro Glu Ser Cys Arg Ser Leu Ile Lys Glu Ala Ser 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Ser Val Tyr Gln Trp Met Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Gln Arg Asn Gly Glu Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Gly Lys Ser Lys Ile Ser Ile Pro Asp Pro Leu Val Thr Val 
            260                 265                 270         


Arg Leu Val Phe Asn Phe Pro Thr Gly Ile Met Met Leu Gly Asn Gly 
        275                 280                 285             


Ile Ile Phe Gly Ser Tyr Tyr Ala Val Leu Ser Ser Val Pro Ser Gln 
    290                 295                 300                 


Phe Glu Ile Val Tyr Gly Phe Asn Asp Ile Gln Val Gly Ile Ala Tyr 
305                 310                 315                 320 


Ile Pro Ala Gly Leu Gly Thr Leu Phe Ser Ala Phe Thr Asn Gly Ile 
                325                 330                 335     


Ile Leu Asp Trp Asn Tyr Arg Arg Val Glu Ala Ala Leu Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Met Ala Val Pro Met Met Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Gly Phe Leu Ile Tyr Phe Arg Ser Pro Ile Trp Ala Pro 
385                 390                 395                 400 


Val Ala Met Leu Phe Leu Ile Ala Phe Ser Val Thr Ala Gly Tyr Asn 
                405                 410                 415     


Val Val Asn Ile Val Val Val Asp Leu Asn Tyr Ser Arg Pro Ala Ser 
            420                 425                 430         


Ala Leu Ala Ala Asn Asn Leu Leu Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Val Leu Ile His Pro Leu Leu Asn Trp Ile Gly Arg Ala Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Ser Pro Leu Leu Leu 
465                 470                 475                 480 


Val Ser Tyr Arg Tyr Gly Leu Ala Trp Lys Ala Ser Ser Asn Arg 
                485                 490                 495 


<210>  337
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  337

Met Ala Gly Asn Pro Asp Thr Glu Gly Gln Ala Thr Glu Thr Ser Ser 
1               5                   10                  15      


Leu Ile Ser Arg Lys Ser Thr Gln Ala Arg Tyr Ser Leu Tyr Ser Thr 
            20                  25                  30          


Thr Gln Arg Arg Val Leu Ile Ser Thr Ala Ser Leu Ala Ser Thr Leu 
        35                  40                  45              


Thr Pro Ile Ser Ala Asn Leu Tyr Tyr Pro Ile Val Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Val Ser His Ala Leu Met Asn Trp Thr Ile Met Gly 
65                  70                  75                  80  


Tyr Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Leu Tyr Leu Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Phe Pro Ala Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Ile Val Ala 
    130                 135                 140                 


Val Gly Ser Gly Ile Ala Ala Asp Ile Val Ser Ser Gly Glu Arg Gly 
145                 150                 155                 160 


Met Tyr Leu Gly Leu Ala Ser Leu Gly Thr Gly Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Leu Leu Ser His Phe Phe Gly Trp Pro Thr 
            180                 185                 190         


Ile Phe Phe Phe Ile Ala Ile Val Gly Thr Phe Phe Phe Val Pro Tyr 
        195                 200                 205             


Val Leu Phe Phe Pro Glu Thr Cys Lys Ser Met Val Lys Asp Gly Thr 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Ser Val Tyr Gln Trp Leu Lys Gln 
225                 230                 235                 240 


Arg Ser Lys Gln Arg Asn Gly Asp Glu Glu Ser Glu Gly Asp Leu Thr 
                245                 250                 255     


Tyr Ser Ala Arg Ser Arg Ile Ser Leu Pro Asp Pro Val Val Thr Leu 
            260                 265                 270         


Arg Val Leu Phe Gln Phe Pro Thr Gly Leu Leu Leu Leu Gly Asn Gly 
        275                 280                 285             


Leu Ile Trp Gly Ser Tyr Tyr Ala Leu Leu Ser Ser Leu Pro Ser Gln 
    290                 295                 300                 


Phe Glu Met Ile Phe Gly Tyr Asn Asp Leu Gln Ile Gly Ile Ala Phe 
305                 310                 315                 320 


Ile Pro Gly Gly Leu Gly Ser Leu Phe Ser Gly Phe Thr Asn Gly Leu 
                325                 330                 335     


Ile Val Asp Trp Asn Tyr Lys Lys Leu Glu Ala Ala Val Lys Glu Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Leu Gly Leu Pro Met Met Ile Leu Ala Gly Ile Ser Leu 
    370                 375                 380                 


Gly Ile Phe Gly Trp Leu Leu Phe Phe Arg Thr Pro Ile Trp Gly Pro 
385                 390                 395                 400 


Leu Ala Leu Val Phe Leu Ile Ala Phe Ser Val Ser Ala Gly Tyr Asn 
                405                 410                 415     


Val Ile Asn Val Leu Val Val Glu Val Asn Tyr Ser Arg Pro Ala Ser 
            420                 425                 430         


Ala Leu Ala Ala Asn Asn Val Ile Arg Cys Thr Leu Gly Ala Ala Ala 
        435                 440                 445             


Thr Leu Leu Ile His Pro Leu Leu Asn Trp Val Gly Arg Gly Tyr Thr 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Ala Ile Ile Ala Ala Thr Pro Leu Leu Met 
465                 470                 475                 480 


Ile Ser Tyr Arg Trp Gly Leu Ala Trp Arg Gly Ser Ser Asn Arg 
                485                 490                 495 


<210>  338
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 328

<400>  338

Met Ala Ala Asn Pro Asp Ser Glu Gly Gln Gly Ser Glu Thr Ser Ser 
1               5                   10                  15      


Leu Leu Thr Arg Lys Ser Ser Gln Ala Arg Tyr Ser Val Phe Ser Thr 
            20                  25                  30          


Thr Gln Lys Arg Met Leu Ile Ser Thr Ala Ser Leu Gly Ser Thr Leu 
        35                  40                  45              


Ser Pro Leu Ser Ala Asn Met Tyr Tyr Pro Leu Leu Asn Ser Met Ala 
    50                  55                  60                  


Lys Asp Leu His Leu Ser His Ala Leu Ile Asn Trp Thr Ile Met Gly 
65                  70                  75                  80  


Phe Met Leu Leu Gln Ala Phe Ala Pro Thr Ile Ala Gly Ser Ile Ala 
                85                  90                  95      


Asp Val Val Gly Arg Arg Pro Val Tyr Ile Phe Cys Phe Leu Ile Tyr 
            100                 105                 110         


Ile Ala Ser Asp Val Ala Leu Ala Leu Gln Arg Thr Trp Pro Gly Leu 
        115                 120                 125             


Val Ile Leu Arg Ala Val Gln Ser Ser Gly Ser Ser Pro Leu Val Ala 
    130                 135                 140                 


Leu Ala Ser Ala Val Ala Gly Asp Ile Ile Ser Ser Gly Glu Arg Gly 
145                 150                 155                 160 


Met Tyr Val Gly Leu Ala Ser Ile Ala Thr Ala Leu Ala Pro Ser Leu 
                165                 170                 175     


Gly Pro Leu Ile Gly Gly Ile Leu Ser His Phe Phe Gly Trp Pro Ser 
            180                 185                 190         


Met Phe Trp Phe Leu Ala Ile Leu Gly Thr Phe Phe Phe Val Pro Phe 
        195                 200                 205             


Leu Leu Phe Phe Pro Glu Ser Cys Arg Thr Leu Ile Lys Asp Gly Thr 
    210                 215                 220                 


Val Gln Pro Leu Gly Phe Asn Gln Ser Leu Tyr Gln Trp Met Arg Gln 
225                 230                 235                 240 


Arg Ser Lys Gln Arg Gln Gly Glu Glu Glu Ser Glu Gly Asp Ile Thr 
                245                 250                 255     


Trp Ser Gly Arg Thr Arg Val Ser Ile Pro Asp Pro Val Val Thr Leu 
            260                 265                 270         


Arg Leu Leu Phe Gln Phe Pro Thr Gly Ile Met Met Leu Gly Asn Gly 
        275                 280                 285             


Leu Met Phe Ala Ser Phe Tyr Ala Leu Leu Ser Ser Leu Pro Ser Gln 
    290                 295                 300                 


Phe Glu Met Val Tyr Gly Phe Asn Asp Ile Gln Val Gly Ile Ala Phe 
305                 310                 315                 320 


Ile Pro Ala Ala Leu Gly Ser Leu Phe Ser Ala Phe Thr Asn Gly Leu 
                325                 330                 335     


Ile Leu Asp Trp Asn Tyr Arg Arg Leu Glu Ala Ala Ile Lys Asp Arg 
            340                 345                 350         


Ser Asp His Glu Arg Ser Thr Lys Glu Asn Phe Pro Phe Glu Lys Thr 
        355                 360                 365             


Arg Leu His Val Ala Val Pro Met Leu Ile Leu Ala Ala Ile Ser Ile 
    370                 375                 380                 


Gly Ile Tyr Ala Trp Leu Leu Tyr Phe Arg Thr Pro Leu Phe Ala Pro 
385                 390                 395                 400 


Leu Ala Ile Val Phe Leu Val Ala Phe Ser Leu Thr Gly Ala Trp Asn 
                405                 410                 415     


Leu Met Asn Ile Leu Ile Val Glu Ile Asn Tyr Ser Arg Pro Ala Ser 
            420                 425                 430         


Ala Met Ala Ala Asn Asn Leu Val Arg Cys Thr Leu Ala Ala Ala Ala 
        435                 440                 445             


Thr Val Leu Val His Pro Leu Leu Gln Trp Val Gly Arg Gly Trp Ser 
    450                 455                 460                 


Phe Thr Cys Ile Ala Gly Gly Met Ile Ala Ala Thr Pro Leu Leu Leu 
465                 470                 475                 480 


Leu Ser Tyr Lys Phe Gly Leu Ala Trp Arg Gly Ser Ser Asn Arg 
                485                 490                 495 


<210>  339
<211>  693
<212>  DNA
<213>  Bipolaris maydis

<400>  339
atgcgtcctt ttgccttacc gccactttgt gtcctgcttg ctgccacctt acgatcgaca       60

gcagcatcac cgccaatcgc atcacaggac ggattctttt ttggcaatcc atctttggac      120

tgtgaatttg tgtcgcagcc tcgaatctac tctatttttt cttcccttga gaccgacgtt      180

accaacctaa tcaatcacat tgcaccagat gttgatttta ctgtagttgg ccatcagcct      240

ttagcaggac actatcatga cttgaagcac ttctatgtta acgcgctata ccgactcaac      300

aactgcataa ggctaaagta tcctgatgag taccgtatcg agcttcagta catcacgggt      360

ggttgcgacc aaaagtggag tgttcaggag gttttgttta gtggacgggc aaataatggt      420

atgcaattct gatggagtat ccaaatctga agctcatttc aactaggcga gaactggtcg      480

atggtgaacg tctggatcac tcggtgggaa catgataaaa tggtcgagat tcgaacttat      540

gtcgacgcag cgcgggtaac agaactactt cacgataatg aagtgtggtc caactcatcg      600

acgcattcag accatactac gtttcttccg ggaccacgag gaatgcccca aacatcggcg      660

ctagagtctc ttctagcgaa aataggatat tag                                   693


<210>  340
<211>  214
<212>  PRT
<213>  Bipolaris maydis

<400>  340

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Tyr Ser Ile Phe Ser Ser Leu Glu Thr Asp Val Thr Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Leu Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Leu Asn Asn Cys Ile Arg Leu Lys Tyr Pro Asp Glu Tyr Arg 
            100                 105                 110         


Ile Glu Leu Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Val Leu Phe Ser Gly Arg Ala Asn Asn Gly Glu Asn Trp Ser 
    130                 135                 140                 


Met Val Asn Val Trp Ile Thr Arg Trp Glu His Asp Lys Met Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Val Asp Ala Ala Arg Val Thr Glu Leu Leu His Asp 
                165                 170                 175     


Asn Glu Val Trp Ser Asn Ser Ser Thr His Ser Asp His Thr Thr Phe 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Ala Lys Ile Gly Tyr 
    210                 


<210>  341
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  341

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Tyr Ser Leu Phe Ser Ser Leu Glu Thr Asp Val Ser Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Ile Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Val Asn Asn Cys Leu Arg Leu Lys Tyr Pro Glu Glu Tyr Arg 
            100                 105                 110         


Ile Glu Leu Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Met Leu Phe Ser Gly Arg Ala Asn Asn Gly Glu Asn Trp Ser 
    130                 135                 140                 


Ile Ile Asn Val Trp Ile Thr Arg Trp Glu His Asp Lys Met Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Val Asp Ala Ala Arg Val Thr Asp Leu Leu His Asp 
                165                 170                 175     


Asn Glu Val Trp Ser Asn Ser Thr Thr His Ser Asp His Thr Thr Phe 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Ala Lys Ile Gly Tyr 
    210                 


<210>  342
<211>  214
<212>  PRT
<213>  Bipolaris maydis

<400>  342

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Ile Phe Ser Ser Leu Glu Thr Asp Met Thr Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Trp Thr Val Met Gly His Gln Pro 
65                  70                  75                  80  


Leu Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Leu Asn Asn Cys Ile Arg Leu Lys Tyr Pro Asp Glu Tyr Arg 
            100                 105                 110         


Leu Glu Leu Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Ile Leu Phe Ser Gly Arg Ala Asn Asn Gly Glu Asn Trp Ser 
    130                 135                 140                 


Met Ile Asn Val Trp Ile Thr Arg Trp Glu His Asp Lys Met Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Ile Asp Ala Ala Arg Val Thr Glu Val Leu His Asp 
                165                 170                 175     


Asn Glu Val Trp Ser Asn Ser Ser Thr His Ser Asp His Thr Thr Tyr 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Gly Lys Ile Gly Tyr 
    210                 


<210>  343
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  343

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Tyr Ser Leu Phe Ser Thr Leu Glu Thr Asp Met Thr Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Leu Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Leu Asn Asn Cys Leu Lys Met Lys Tyr Pro Glu Glu Phe Arg 
            100                 105                 110         


Ile Glu Leu Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Val Leu Phe Ser Gly Arg Ala Asn Asn Gly Glu Asn Trp Ser 
    130                 135                 140                 


Ile Val Asn Val Trp Ile Thr Arg Phe Glu His Asp Lys Met Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Val Asp Ala Ala Arg Ile Thr Asp Leu Leu His Asp 
                165                 170                 175     


Asn Glu Ile Trp Ser Asn Ser Ser Thr His Ser Asp His Thr Thr Phe 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Leu Pro Gln Thr Ser Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Gly Lys Ile Gly Tyr 
    210                 


<210>  344
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  344

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Leu Phe Ser Ser Leu Glu Thr Asp Val Thr Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Leu Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Val Asn Asn Cys Ile Arg Ile Lys Tyr Pro Glu Glu Phe Arg 
            100                 105                 110         


Leu Glu Leu Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Met Leu Phe Ser Gly Arg Ala Asn Asn Gly Glu Asn Trp Ser 
    130                 135                 140                 


Ile Val Asn Val Trp Val Thr Arg Trp Glu His Asp Lys Ile Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Val Asp Ala Ala Lys Val Thr Glu Leu Leu His Asp 
                165                 170                 175     


Asn Glu Leu Trp Ser Asn Ser Ser Thr His Ser Asp His Ser Thr Phe 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Val 
        195                 200                 205             


Leu Ala Lys Ile Gly Tyr 
    210                 


<210>  345
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  345

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Leu Phe Ser Ser Leu Glu Thr Asp Met Ser Asn Leu Ile 
    50                  55                  60                  


Asn His Val Ala Pro Asp Val Asp Trp Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Ile Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Leu Asn Asn Cys Ile Arg Ile Lys Tyr Pro Asp Glu Phe Arg 
            100                 105                 110         


Leu Glu Leu Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Met Leu Phe Ser Ala Arg Ala Asn Asn Gly Asp Asn Trp Ser 
    130                 135                 140                 


Ile Val Asn Val Trp Ile Thr Arg Trp Asp His Asp Lys Met Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Val Asp Ala Ala Arg Val Thr Glu Val Leu His Glu 
                165                 170                 175     


Asn Glu Val Trp Thr Asn Ser Thr Thr His Ser Glu His Ser Thr Tyr 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Ala Lys Ile Gly Tyr 
    210                 


<210>  346
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  346

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Ile Phe Ser Ser Leu Glu Thr Asp Met Ser Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Phe Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Leu Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Leu Asn Asn Cys Ile Arg Met Lys Tyr Pro Asp Glu Tyr Arg 
            100                 105                 110         


Ile Glu Val Gln Tyr Ile Thr Gly Gly Cys Glu Gln Arg Trp Ser Val 
        115                 120                 125             


Gln Glu Val Leu Phe Ser Gly Arg Ala Asn Asn Gly Asp Asn Trp Ser 
    130                 135                 140                 


Ile Val Asn Val Trp Ile Ser Arg Phe Glu His Glu Lys Ile Val Glu 
145                 150                 155                 160 


Val Arg Thr Tyr Val Asp Ala Ala Lys Ile Thr Glu Val Leu His Glu 
                165                 170                 175     


Asn Glu Ile Trp Ser Asn Ser Ser Ser His Ser Glu His Ser Thr Phe 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Ala Lys Ile Gly Tyr 
    210                 


<210>  347
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  347

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Leu Phe Ser Ser Leu Glu Thr Asp Met Ser Asn Leu Ile 
    50                  55                  60                  


Asn His Val Ala Pro Asp Val Asp Phe Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Ile Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Leu Asn Asn Cys Ile Lys Met Lys Tyr Pro Glu Glu Tyr Arg 
            100                 105                 110         


Val Glu Leu Asn Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Met Leu Phe Ser Gly Arg Ala Asn Asn Gly Glu Asn Trp Ser 
    130                 135                 140                 


Ile Ile Asn Val Trp Val Thr Arg Phe Asp His Glu Lys Val Val Glu 
145                 150                 155                 160 


Val Arg Thr Tyr Val Asp Ala Ala Lys Ile Thr Asp Val Ile His Glu 
                165                 170                 175     


Asn Glu Ile Trp Thr Asn Ser Thr Ser His Ser Asp His Ser Thr Tyr 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Ser Ala Leu Glu Ser Met 
        195                 200                 205             


Leu Ala Lys Ile Gly Tyr 
    210                 


<210>  348
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  348

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Leu Phe Ser Thr Leu Glu Thr Asp Met Thr Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Trp Thr Val Val Gly His Gln Pro 
65                  70                  75                  80  


Ile Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Val Asn Asn Cys Leu Lys Ile Lys Tyr Pro Asp Glu Tyr Arg 
            100                 105                 110         


Leu Glu Val Gln Tyr Ile Thr Gly Gly Cys Asp Gln Lys Trp Ser Val 
        115                 120                 125             


Gln Glu Ile Leu Phe Ser Gly Arg Ala Asn Asn Gly Asp Asn Trp Ser 
    130                 135                 140                 


Val Val Asn Leu Trp Val Ser Arg Trp Asp His Asp Lys Ile Val Glu 
145                 150                 155                 160 


Ile Arg Thr Tyr Ile Asp Ala Gly Arg Ile Thr Asp Val Ile His Glu 
                165                 170                 175     


Asn Glu Ile Trp Ser Asn Ser Ser Ser His Ser Glu His Thr Thr Trp 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Gln Thr Thr Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Gly Lys Ile Gly Tyr 
    210                 


<210>  349
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  349

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Leu Phe Ser Ser Leu Glu Thr Asp Met Ser Asn Val Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Trp Thr Val Met Gly His Gln Pro 
65                  70                  75                  80  


Ile Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Val Asn Asn Cys Ile Lys Ile Lys Tyr Pro Glu Glu Phe Arg 
            100                 105                 110         


Val Glu Val Asn Tyr Ile Thr Gly Gly Cys Glu Gln Arg Trp Ser Val 
        115                 120                 125             


Gln Glu Ile Leu Phe Ser Ala Arg Ala Asn Asn Gly Asp Asn Trp Ser 
    130                 135                 140                 


Ile Val Asn Val Trp Val Thr Lys Phe Glu His Glu Lys Ile Val Glu 
145                 150                 155                 160 


Val Arg Thr Tyr Ile Asp Ala Gly Lys Ile Thr Asp Ile Leu His Glu 
                165                 170                 175     


Asn Glu Val Trp Ser Asn Ser Thr Ser His Ser Glu His Ser Thr Tyr 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Leu Pro Gln Thr Ser Ala Leu Glu Ser Met 
        195                 200                 205             


Leu Gly Lys Ile Gly Tyr 
    210                 


<210>  350
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of SEQ ID NO: 340

<400>  350

Met Arg Pro Phe Ala Leu Pro Pro Leu Cys Val Leu Leu Ala Ala Thr 
1               5                   10                  15      


Leu Arg Ser Thr Ala Ala Ser Pro Pro Ile Ala Ser Gln Asp Gly Phe 
            20                  25                  30          


Phe Phe Gly Asn Pro Ser Leu Asp Cys Glu Phe Val Ser Gln Pro Arg 
        35                  40                  45              


Ile Trp Ser Leu Phe Ser Thr Leu Glu Thr Asp Met Ser Asn Leu Ile 
    50                  55                  60                  


Asn His Ile Ala Pro Asp Val Asp Trp Thr Val Met Gly His Gln Pro 
65                  70                  75                  80  


Ile Ala Gly His Tyr His Asp Leu Lys His Phe Tyr Val Asn Ala Leu 
                85                  90                  95      


Tyr Arg Val Asn Asn Cys Leu Lys Met Lys Tyr Pro Glu Glu Phe Arg 
            100                 105                 110         


Leu Glu Leu Asn Tyr Ile Thr Gly Gly Cys Asp Gln Arg Trp Ser Val 
        115                 120                 125             


Gln Glu Met Leu Phe Ser Gly Arg Ala Asn Asn Gly Asp Asn Trp Ser 
    130                 135                 140                 


Ile Val Asn Val Trp Val Ser Arg Phe Asp His Glu Lys Ile Val Glu 
145                 150                 155                 160 


Val Arg Thr Tyr Ile Asp Ala Gly Lys Ile Thr Asp Val Leu His Asp 
                165                 170                 175     


Asn Glu Ile Trp Thr Asn Ser Thr Ser His Ser Glu His Ser Thr Trp 
            180                 185                 190         


Leu Pro Gly Pro Arg Gly Met Pro Asn Thr Thr Ala Leu Glu Ser Leu 
        195                 200                 205             


Leu Gly Lys Ile Gly Tyr 
    210                 


