                         SEQUENCE LISTING

<110>  Pieris AG
 
<120>  NOVEL SPECIFIC-BINDING POLYPEPTIDES AND USES THEREOF

<130>  PIE15066PCT

<150>  EP 14169488.5
<151>  2014-05-22

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  151
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  1

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly 
145                 150     


<210>  2
<211>  178
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  2

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys Tyr Gln Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Ala Ile 
                165                 170                 175     


Asp Gly 
        


<210>  3
<211>  351
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  3

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                165                 170                 175     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly 
            180                 185                 190         


Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp 
        195                 200                 205             


Lys Asp Pro Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp 
    210                 215                 220                 


Lys Ser Tyr Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys 
225                 230                 235                 240 


Tyr Gln Ile Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr 
                245                 250                 255     


Leu Gly Gly Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg 
            260                 265                 270         


Val Val Ser Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr 
        275                 280                 285             


Val Tyr Gln Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr 
    290                 295                 300                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
305                 310                 315                 320 


Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp 
                325                 330                 335     


Gln Ala Ile Asp Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            340                 345                 350     


<210>  4
<211>  349
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  4

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys Tyr Gln Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Ala Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Glu 
            180                 185                 190         


Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met Thr Val 
        195                 200                 205             


Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val Thr Pro Met Thr 
    210                 215                 220                 


Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr Met Asp 
225                 230                 235                 240 


Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu Glu Lys Thr Asp 
                245                 250                 255     


Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala Tyr Ile 
            260                 265                 270         


Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr Ser Glu Gly Asp 
        275                 280                 285             


Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly Arg Asp Pro Lys 
    290                 295                 300                 


Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Ser 
                325                 330                 335     


Ser Pro Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            340                 345                 


<210>  5
<211>  406
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  5

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                165                 170                 175     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly 
            180                 185                 190         


Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp 
        195                 200                 205             


Lys Asp Pro Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp 
    210                 215                 220                 


Lys Ser Tyr Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys 
225                 230                 235                 240 


Tyr Gln Ile Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr 
                245                 250                 255     


Leu Gly Gly Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg 
            260                 265                 270         


Val Val Ser Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr 
        275                 280                 285             


Val Tyr Gln Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr 
    290                 295                 300                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
305                 310                 315                 320 


Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp 
                325                 330                 335     


Gln Ala Ile Asp Gly Ser Ala Gly Ala Val Asp Ala Asn Ser Leu Ala 
            340                 345                 350         


Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser 
        355                 360                 365             


Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val 
    370                 375                 380                 


Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro Ser Ala Trp Ser 
385                 390                 395                 400 


His Pro Gln Phe Glu Lys 
                405     


<210>  6
<211>  556
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  6

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp 
                165                 170                 175     


Tyr Leu Lys Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu 
            180                 185                 190         


Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        195                 200                 205             


Glu Ala Lys Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys 
    210                 215                 220                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
225                 230                 235                 240 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr 
                245                 250                 255     


Ile Phe Tyr Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp 
            260                 265                 270         


Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe 
        275                 280                 285             


Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile 
    290                 295                 300                 


Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala 
                325                 330                 335     


Pro Pro Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln 
            340                 345                 350         


Phe His Gly Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Leu Leu 
        355                 360                 365             


Arg Glu Asp Lys Asp Pro Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu 
    370                 375                 380                 


Lys Glu Asp Lys Ser Tyr Asp Val Thr Arg Val Glu Phe Gly Ala Lys 
385                 390                 395                 400 


Thr Tyr Lys Tyr Gln Ile Gly Thr Phe Val Pro Gly Ser Gln Pro Gly 
                405                 410                 415     


Glu Phe Thr Leu Gly Gly Ile Glu Ser Met Pro Gly Met Thr Ser Phe 
            420                 425                 430         


Leu Val Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Ile Val Phe 
        435                 440                 445             


Phe Lys Tyr Val Tyr Gln Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr 
    450                 455                 460                 


Gly Arg Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg 
465                 470                 475                 480 


Phe Ser Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val 
                485                 490                 495     


Pro Ile Asp Gln Ala Ile Asp Gly Ser Gly Gly Gly Gly Ser Leu Ala 
            500                 505                 510         


Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser 
        515                 520                 525             


Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val 
    530                 535                 540                 


Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
545                 550                 555     


<210>  7
<211>  240
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  7

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys Tyr Gln Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Ala Ile 
                165                 170                 175     


Asp Gly Ser Gly Gly Gly Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala 
            180                 185                 190         


Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
        195                 200                 205             


Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
    210                 215                 220                 


Ile Leu Ala Ala Leu Pro Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
225                 230                 235                 240 


<210>  8
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  8

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Ser Gly Gly Gly Gly Ser Leu 
145                 150                 155                 160 


Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
                165                 170                 175     


Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
            180                 185                 190         


Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Ala Trp 
        195                 200                 205             


Ser His Pro Gln Phe Glu Lys 
    210                 215 


<210>  9
<211>  403
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  9

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                165                 170                 175     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly 
            180                 185                 190         


Lys Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp 
        195                 200                 205             


Lys Asp Pro Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp 
    210                 215                 220                 


Lys Ser Tyr Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys 
225                 230                 235                 240 


Tyr Gln Ile Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr 
                245                 250                 255     


Leu Gly Gly Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg 
            260                 265                 270         


Val Val Ser Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr 
        275                 280                 285             


Val Tyr Gln Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr 
    290                 295                 300                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
305                 310                 315                 320 


Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp 
                325                 330                 335     


Gln Ala Ile Asp Gly Ser Gly Gly Gly Gly Ser Leu Ala Glu Ala Lys 
            340                 345                 350         


Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr 
        355                 360                 365             


Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu 
    370                 375                 380                 


Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Ala Trp Ser His Pro Gln 
385                 390                 395                 400 


Phe Glu Lys 
            


<210>  10
<211>  378
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  10

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp 
                165                 170                 175     


Tyr Leu Lys Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu 
            180                 185                 190         


Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        195                 200                 205             


Glu Ala Lys Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys 
    210                 215                 220                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
225                 230                 235                 240 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr 
                245                 250                 255     


Ile Phe Tyr Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp 
            260                 265                 270         


Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe 
        275                 280                 285             


Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile 
    290                 295                 300                 


Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly Ser Asp Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser 
                325                 330                 335     


Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr 
            340                 345                 350         


Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
        355                 360                 365             


Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    370                 375             


<210>  11
<211>  390
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  11

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp 
225                 230                 235                 240 


Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met Thr 
                245                 250                 255     


Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val Thr Pro Met 
            260                 265                 270         


Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr Met 
        275                 280                 285             


Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu Glu Lys Thr 
    290                 295                 300                 


Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala Tyr 
305                 310                 315                 320 


Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr Ser Glu Gly 
                325                 330                 335     


Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly Arg Asp Pro 
            340                 345                 350         


Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala 
        355                 360                 365             


Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr 
    370                 375                 380                 


Ser Ser Pro Gly Ser Asp 
385                 390 


<210>  12
<211>  553
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  12

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                165                 170                 175     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            180                 185                 190         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        195                 200                 205             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    210                 215                 220                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
225                 230                 235                 240 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                245                 250                 255     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            260                 265                 270         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        275                 280                 285             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    290                 295                 300                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
305                 310                 315                 320 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                325                 330                 335     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            340                 345                 350         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        355                 360                 365             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    370                 375                 380                 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
                405                 410                 415     


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            420                 425                 430         


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        435                 440                 445             


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    450                 455                 460                 


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
465                 470                 475                 480 


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                485                 490                 495     


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            500                 505                 510         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        515                 520                 525             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    530                 535                 540                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp 
545                 550             


<210>  13
<211>  553
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  13

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp 
225                 230                 235                 240 


Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys Ala Met Thr 
                245                 250                 255     


Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val Thr Pro Met 
            260                 265                 270         


Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys Val Thr Met 
        275                 280                 285             


Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu Glu Lys Thr 
    290                 295                 300                 


Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His Val Ala Tyr 
305                 310                 315                 320 


Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr Ser Glu Gly 
                325                 330                 335     


Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly Arg Asp Pro 
            340                 345                 350         


Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala 
        355                 360                 365             


Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr 
    370                 375                 380                 


Ser Ser Pro Gly Ser Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
                405                 410                 415     


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            420                 425                 430         


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        435                 440                 445             


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    450                 455                 460                 


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
465                 470                 475                 480 


Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile Phe Tyr 
                485                 490                 495     


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            500                 505                 510         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        515                 520                 525             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    530                 535                 540                 


Ser Glu Thr Ser Ser Pro Gly Ser Asp 
545                 550             


<210>  14
<211>  55
<212>  PRT
<213>  artificial

<220>
<223>  albumin binding domain

<400>  14

Ser Ala Gly Ala Val Asp Ala Asn Ser Leu Ala Glu Ala Lys Val Leu 
1               5                   10                  15      


Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr Lys Asn 
            20                  25                  30          


Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu Ile Asp 
        35                  40                  45              


Glu Ile Leu Ala Ala Leu Pro 
    50                  55  


<210>  15
<211>  52
<212>  PRT
<213>  artificial

<220>
<223>  albumin binding domain

<400>  15

Ser Gly Gly Gly Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala 
1               5                   10                  15      


Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp 
            20                  25                  30          


Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu 
        35                  40                  45              


Ala Ala Leu Pro 
    50          


<210>  16
<211>  227
<212>  PRT
<213>  artificial

<220>
<223>  Fc portion

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  17
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  protein tag

<400>  17

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  18
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  synthetic linker

<400>  18

Ser Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  19
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  synthetic linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  20
<211>  2
<212>  PRT
<213>  artificial

<220>
<223>  synthetic linker

<400>  20

Ser Asp 
1       


<210>  21
<211>  453
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  21
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gatttttggt gttctgggat tcatgaggag tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattg agggatttct tcaagagttt      180

aaggcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccgtgtgaaa gatcattaca tcttttatag cgagggagat      300

tgtcctggtc cggttccagg ggtgtggctc gtgggcagag accccaagaa caacctggaa      360

gccttggagg actttgagaa agccgcagga gcccgcggac tcagcacgga gagcatcctc      420

atccccaggc agagcgaaac cagctctcca ggg                                   453


<210>  22
<211>  534
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  22
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

ttgctgcgtg aggataagga tccgaggaaa atgacggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac ccgggtggag tttggggcta agacatacaa gtaccagatt      240

gggacctttg tgccggggag ccagccgggc gagtttactt taggcggtat tgaaagtatg      300

ccgggcatga catcattttt ggtccgtgtc gtgagcacca actacaacca gcatgccata      360

gtgttcttca agtatgtgta tcagaaccgc gagtattttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc aggctatcga cggc            534


<210>  23
<211>  1053
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  23
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gatttttggt gttctgggat tcatgaggag tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattg agggatttct tcaagagttt      180

aaggcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccgtgtgaaa gatcattaca tcttttatag cgagggagat      300

tgtcctggtc cggttccagg ggtgtggctc gtgggcagag accccaagaa caacctggaa      360

gccttggagg actttgagaa agccgcagga gcccgcggac tcagcacgga gagcatcctc      420

atccccaggc agagcgaaac cagctctcca gggagcgacg gtggtggtgg ttctggtggt      480

ggtggatcgc aggactccac ctcagacctg atcccagccc cacctctgag caaggtccct      540

ctgcagcaga acttccagga caaccaattc catgggaaat ggtatgtcgt gggcgaggcc      600

ggaaatcttt tgctgcgtga ggataaggat ccgaggaaaa tgacggcgac catttacgag      660

ttgaaagaag ataaatcata tgacgtcacc cgggtggagt ttggggctaa gacatacaag      720

taccagattg ggacctttgt gccggggagc cagccgggcg agtttacttt aggcggtatt      780

gaaagtatgc cgggcatgac atcatttttg gtccgtgtcg tgagcaccaa ctacaaccag      840

catgccatag tgttcttcaa gtatgtgtat cagaaccgcg agtattttga gatcacactg      900

tacgggcgca cgaaagaact gacaagcgag ctgaaggaaa attttatccg cttttccaaa      960

tctctgggcc tccctgaaaa ccacatcgtc ttccctgtcc caatcgacca ggctatcgac     1020

ggcagcgctt ggtctcaccc gcagttcgaa aaa                                  1053


<210>  24
<211>  1047
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  24
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

ttgctgcgtg aggataagga tccgaggaaa atgacggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac ccgggtggag tttggggcta agacatacaa gtaccagatt      240

gggacctttg tgccggggag ccagccgggc gagtttactt taggcggtat tgaaagtatg      300

ccgggcatga catcattttt ggtccgtgtc gtgagcacca actacaacca gcatgccata      360

gtgttcttca agtatgtgta tcagaaccgc gagtattttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc aggctatcga cggcggcggt      540

ggtggttctg gtggtggtgg atcggcctca gacgaggaga ttcaggatgt gtcagggacg      600

tggtatctga aggccatgac ggtggatttt tggtgttctg ggattcatga ggagtctgtt      660

acgccaatga ctctgactac ccttgaaggc ggcaatctgg aggctaaggt caccatggat      720

attgagggat ttcttcaaga gtttaaggca gtgttagaga agacagatga accgggtaaa      780

tatacggccg atggcggtaa acatgttgcc tatatcattc gcagccgtgt gaaagatcat      840

tacatctttt atagcgaggg agattgtcct ggtccggttc caggggtgtg gctcgtgggc      900

agagacccca agaacaacct ggaagccttg gaggactttg agaaagccgc aggagcccgc      960

ggactcagca cggagagcat cctcatcccc aggcagagcg aaaccagctc tccagggagc     1020

gcttggtctc acccgcagtt cgaaaaa                                         1047


<210>  25
<211>  1218
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  25
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gatttttggt gttctgggat tcatgaggag tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattg agggatttct tcaagagttt      180

aaggcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccgtgtgaaa gatcattaca tcttttatag cgagggagat      300

tgtcctggtc cggttccagg ggtgtggctc gtgggcagag accccaagaa caacctggaa      360

gccttggagg actttgagaa agccgcagga gcccgcggac tcagcacgga gagcatcctc      420

atccccaggc agagcgaaac cagctctcca gggagcgacg gtggtggtgg ttctggtggt      480

ggtggatcgc aggactccac ctcagacctg atcccagccc cacctctgag caaggtccct      540

ctgcagcaga acttccagga caaccaattc catgggaaat ggtatgtcgt gggcgaggcc      600

ggaaatcttt tgctgcgtga ggataaggat ccgaggaaaa tgacggcgac catttacgag      660

ttgaaagaag ataaatcata tgacgtcacc cgggtggagt ttggggctaa gacatacaag      720

taccagattg ggacctttgt gccggggagc cagccgggcg agtttacttt aggcggtatt      780

gaaagtatgc cgggcatgac atcatttttg gtccgtgtcg tgagcaccaa ctacaaccag      840

catgccatag tgttcttcaa gtatgtgtat cagaaccgcg agtattttga gatcacactg      900

tacgggcgca cgaaagaact gacaagcgag ctgaaggaaa attttatccg cttttccaaa      960

tctctgggcc tccctgaaaa ccacatcgtc ttccctgtcc caatcgacca ggctatcgac     1020

ggcagcgctg gtgccgtcga cgctaactct ctggctgaag ctaaagttct ggctaaccgt     1080

gaactggaca aatacggtgt ttccgactac tacaaaaacc tcatcaacaa cgctaaaacc     1140

gttgaaggtg ttaaagctct gatcgacgaa attctcgcag cactgccgag cgcttggtct     1200

cacccgcagt tcgaaaaa                                                   1218


<210>  26
<211>  1671
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  26
gcaagtgatg aagaaattca ggatgttagc ggcacctggt atctgaaagc aatgaccgtt       60

gatttttggt gcagcggtat tcatgaagaa agcgttaccc cgatgaccct gaccaccctg      120

gaaggtggta atctggaagc aaaagttacc atggatattg agggttttct gcaagaattt      180

aaagccgtgc tggaaaaaac cgatgaaccg ggtaaatata ccgcagatgg tggtaaacat      240

gtggcctata ttatccgtag ccgtgtgaaa gatcactata tcttttatag cgaaggtgat      300

tgtccgggtc cggttccggg tgtttggctg gttggtcgtg atccgaaaaa taacctggaa      360

gcactggaag attttgaaaa agcagccggt gcacgtggtc tgagcaccga aagcattctg      420

attccgcgtc agagcgaaac cagcagtcct ggatccgacg gtggtggtgg ttctggtggt      480

ggtggatcgg cctcagacga ggagattcag gatgtgtcag ggacgtggta tctgaaggcc      540

atgacggtgg atttttggtg ttctgggatt catgaggagt ctgttacgcc aatgactctg      600

actacccttg aaggcggcaa tctggaggct aaggtcacca tggatattga gggatttctt      660

caagagttta aggcagtgtt agagaagaca gatgaaccgg gtaaatatac ggccgatggc      720

ggtaaacatg ttgcctatat cattcgcagc cgtgtgaaag atcattacat cttttatagc      780

gagggagatt gtcctggtcc ggttccaggg gtgtggctcg tgggcagaga ccccaagaac      840

aacctggaag ccttggagga ctttgagaaa gccgcaggag cccgcggact cagcacggag      900

agcatcctca tccccaggca gagcgaaacc agctctccag ggagcgacgg cggaggtggc      960

tcaggaggtg gcggatccca ggactccacc tcagacctga tcccagcccc acctctgagc     1020

aaggtccctc tgcagcagaa cttccaggac aaccaattcc atgggaaatg gtatgtcgtg     1080

ggcgaggccg gaaatctttt gctgcgtgag gataaggatc cgaggaaaat gacggcgacc     1140

atttacgagt tgaaagaaga taaatcatat gacgtcaccc gggtggagtt tggggctaag     1200

acatacaagt accagattgg gacctttgtg ccggggagcc agccgggcga gtttacttta     1260

ggcggtattg aaagtatgcc gggcatgaca tcatttttgg tccgtgtcgt gagcaccaac     1320

tacaaccagc atgccatagt gttcttcaag tatgtgtatc agaaccgcga gtattttgag     1380

atcacactgt acgggcgcac gaaagaactg acaagcgagc tgaaggaaaa ttttatccgc     1440

ttttccaaat ctctgggcct ccctgaaaac cacatcgtct tccctgtccc aatcgaccag     1500

gctatcgacg gcagcggcgg cggcggctct ctggctgaag ctaaagaagc ggctaacgcg     1560

gaactggact cttacggtgt ttccgacttt tacaaacgtc tcatcgataa agctaaaacc     1620

gttgaaggtg ttgaagctct gaaagacgcg attctcgcag cactgccgaa a              1671


<210>  27
<211>  720
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  27
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

ttgctgcgtg aggataagga tccgaggaaa atgacggcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac ccgggtggag tttggggcta agacatacaa gtaccagatt      240

gggacctttg tgccggggag ccagccgggc gagtttactt taggcggtat tgaaagtatg      300

ccgggcatga catcattttt ggtccgtgtc gtgagcacca actacaacca gcatgccata      360

gtgttcttca agtatgtgta tcagaaccgc gagtattttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc aggctatcga cggcagcggc      540

ggcggcggct ctctggctga agctaaagaa gcggctaacg cggaactgga ctcttacggt      600

gtttccgact tttacaaacg tctcatcgat aaagctaaaa ccgttgaagg tgttgaagct      660

ctgaaagacg cgattctcgc agcactgccg agcgcttggt ctcacccgca gttcgaaaaa      720


<210>  28
<211>  645
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  28
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gatttttggt gttctgggat tcatgaggag tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattg agggatttct tcaagagttt      180

aaggcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccgtgtgaaa gatcattaca tcttttatag cgagggagat      300

tgtcctggtc cggttccagg ggtgtggctc gtgggcagag accccaagaa caacctggaa      360

gccttggagg actttgagaa agccgcagga gcccgcggac tcagcacgga gagcatcctc      420

atccccaggc agagcgaaac cagctctcca gggagcgata gcggcggcgg cggctctctg      480

gctgaagcta aagaagcggc taacgcggaa ctggactctt acggtgtttc cgacttttac      540

aaacgtctca tcgataaagc taaaaccgtt gaaggtgttg aagctctgaa agacgcgatt      600

ctcgcagcac tgccgagcgc ttggtctcac ccgcagttcg aaaaa                      645


<210>  29
<211>  1209
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  29
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gatttttggt gttctgggat tcatgaggag tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattg agggatttct tcaagagttt      180

aaggcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccgtgtgaaa gatcattaca tcttttatag cgagggagat      300

tgtcctggtc cggttccagg ggtgtggctc gtgggcagag accccaagaa caacctggaa      360

gccttggagg actttgagaa agccgcagga gcccgcggac tcagcacgga gagcatcctc      420

atccccaggc agagcgaaac cagctctcca gggagcgacg gcggaggtgg ctcaggaggt      480

ggcggatccc aggactccac ctcagacctg atcccagccc cacctctgag caaggtccct      540

ctgcagcaga acttccagga caaccaattc catgggaaat ggtatgtcgt gggcgaggcc      600

ggaaatcttt tgctgcgtga ggataaggat ccgaggaaaa tgacggcgac catttacgag      660

ttgaaagaag ataaatcata tgacgtcacc cgggtggagt ttggggctaa gacatacaag      720

taccagattg ggacctttgt gccggggagc cagccgggcg agtttacttt aggcggtatt      780

gaaagtatgc cgggcatgac atcatttttg gtccgtgtcg tgagcaccaa ctacaaccag      840

catgccatag tgttcttcaa gtatgtgtat cagaaccgcg agtattttga gatcacactg      900

tacgggcgca cgaaagaact gacaagcgag ctgaaggaaa attttatccg cttttccaaa      960

tctctgggcc tccctgaaaa ccacatcgtc ttccctgtcc caatcgacca ggctatcgac     1020

ggcagcggcg gcggcggctc tctggctgaa gctaaagaag cggctaacgc ggaactggac     1080

tcttacggtg tttccgactt ttacaaacgt ctcatcgata aagctaaaac cgttgaaggt     1140

gttgaagctc tgaaagacgc gattctcgca gcactgccga gcgcttggtc tcacccgcag     1200

ttcgaaaaa                                                             1209


<210>  30
<211>  1134
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  30
gcaagtgatg aagaaattca ggatgttagc ggcacctggt atctgaaagc aatgaccgtt       60

gatttttggt gcagcggtat tcatgaagaa agcgttaccc cgatgaccct gaccaccctg      120

gaaggtggta atctggaagc aaaagttacc atggatattg agggttttct gcaagaattt      180

aaagccgtgc tggaaaaaac cgatgaaccg ggtaaatata ccgcagatgg tggtaaacat      240

gtggcctata ttatccgtag ccgtgtgaaa gatcactata tcttttatag cgaaggtgat      300

tgtccgggtc cggttccggg tgtttggctg gttggtcgtg atccgaaaaa taacctggaa      360

gcactggaag attttgaaaa agcagccggt gcacgtggtc tgagcaccga aagcattctg      420

attccgcgtc agagcgaaac cagcagtcct ggatccgacg gtggtggtgg ttctggtggt      480

ggtggatcgg cctcagacga ggagattcag gatgtgtcag ggacgtggta tctgaaggcc      540

atgacggtgg atttttggtg ttctgggatt catgaggagt ctgttacgcc aatgactctg      600

actacccttg aaggcggcaa tctggaggct aaggtcacca tggatattga gggatttctt      660

caagagttta aggcagtgtt agagaagaca gatgaaccgg gtaaatatac ggccgatggc      720

ggtaaacatg ttgcctatat cattcgcagc cgtgtgaaag atcattacat cttttatagc      780

gagggagatt gtcctggtcc ggttccaggg gtgtggctcg tgggcagaga ccccaagaac      840

aacctggaag ccttggagga ctttgagaaa gccgcaggag cccgcggact cagcacggag      900

agcatcctca tccccaggca gagcgaaacc agctctccag ggagcgatag cggcggcggc      960

ggctctctgg ctgaagctaa agaagcggct aacgcggaac tggactctta cggtgtttcc     1020

gacttttaca aacgtctcat cgataaagct aaaaccgttg aaggtgttga agctctgaaa     1080

gacgcgattc tcgcagcact gccgagcgct tggtctcacc cgcagttcga aaaa           1134


<210>  31
<211>  1173
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  31
gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg       60

tttctgttcc caccaaaacc aaaagatacc ctgatgatct ctagaacccc tgaggtgaca      120

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat      180

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac      240

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag      300

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag      360

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa      420

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag      480

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct      540

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg      600

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc      660

ctgtctctgt ctcctggcaa aggcggcgga ggatccggcg gaggaggtag cgcatcagac      720

gaggaaatcc aggacgtgtc agggacctgg tacctgaaag ccatgaccgt ggatttttgg      780

tgctccggca tccatgagga gtcagtcact cccatgaccc tgacaaccct agaaggtggg      840

aatctggagg ccaaagtgac aatggatatt gagggctttc tccaggagtt caaagccgtc      900

ctcgagaaga cagacgagcc tggaaagtat actgctgatg ggggaaaaca cgtagcctat      960

atcattcgat ctcgggtgaa ggatcattat atcttctatt ccgagggcga ctgccccggc     1020

cctgtgccag gtgtctggct agttgggagg gaccccaaga acaatctcga ggctctggag     1080

gacttcgaga aggcagctgg tgccagggga ttgagcactg agtctatcct tatcccacgc     1140

cagagcgaga cctcaagccc agggtccgac tga                                  1173


<210>  32
<211>  1659
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  32
gcatcagacg aggaaatcca ggacgtgtca gggacctggt acctgaaagc catgaccgtg       60

gatttttggt gctccggcat ccatgaggag tcagtcactc ccatgaccct gacaacccta      120

gaaggtggga atctggaggc caaagtgaca atggatattg agggctttct ccaggagttc      180

aaagccgtcc tcgagaagac agacgagcct ggaaagtata ctgctgatgg gggaaaacac      240

gtagcctata tcattcgatc tcgggtgaag gatcattata tcttctattc cgagggcgac      300

tgccccggcc ctgtgccagg tgtctggcta gttgggaggg accccaagaa caatctcgag      360

gctctggagg acttcgagaa ggcagctggt gccaggggat tgagcactga gtctatcctt      420

atcccacgcc agagcgagac ctcaagccca gggtccgacg gcggtggagg atccggtgga      480

ggcggttctg acaaaaccca cacctgccca ccttgtcctg cccctgaact gctgggagga      540

ccttctgtgt ttctgttccc accaaaacca aaagataccc tgatgatctc tagaacccct      600

gaggtgacat gtgtggtggt ggatgtgtct catgaggacc ctgaggtcaa attcaactgg      660

tacgtggatg gagtggaagt ccacaatgcc aaaaccaagc ctagagagga acagtacaat      720

tcaacctaca gagtggtcag tgtgctgact gtgctgcatc aggattggct gaatggcaag      780

gaatacaagt gtaaagtctc aaacaaggcc ctgcctgctc caattgagaa aacaatctca      840

aaggccaagg gacagcctag ggaaccccag gtctacaccc tgccaccttc aagagaggaa      900

atgaccaaaa accaggtgtc cctgacatgc ctggtcaaag gcttctaccc ttctgacatt      960

gctgtggagt gggagtcaaa tggacagcct gagaacaact acaaaacaac cccccctgtg     1020

ctggattctg atggctcttt ctttctgtac tccaaactga ctgtggacaa gtctagatgg     1080

cagcagggga atgtcttttc ttgctctgtc atgcatgagg ctctgcataa ccactacact     1140

cagaaatccc tgtctctgtc tcccgggaaa gggggtgggg gatccggcgg aggaggtagc     1200

gcatcagacg aggaaatcca ggacgtgtca gggacctggt acctgaaagc catgaccgtg     1260

gatttttggt gctccggcat ccatgaggag tcagtcactc ccatgaccct gacaacccta     1320

gaaggtggga atctggaggc caaagtgaca atggatattg agggctttct ccaggagttc     1380

aaagccgtcc tcgagaagac agacgagcct ggaaagtata ctgctgatgg gggaaaacac     1440

gtagcctata tcattcgatc tcgggtgaag gatcattata tcttctattc cgagggcgac     1500

tgccccggcc ctgtgccagg tgtctggcta gttgggaggg accccaagaa caatctcgag     1560

gctctggagg acttcgagaa ggcagctggt gccaggggat tgagcactga gtctatcctt     1620

atcccacgcc agagcgagac ctcaagccca gggtccgac                            1659


<210>  33
<211>  1659
<212>  DNA
<213>  artificial

<220>
<223>  fusion protein

<400>  33
gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg       60

tttctgttcc caccaaaacc aaaagatacc ctgatgatct ctagaacccc tgaggtgaca      120

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat      180

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac      240

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag      300

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag      360

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa      420

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag      480

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct      540

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg      600

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc      660

ctgtctctgt ctcctggcaa aggcggcgga ggatccggcg gaggaggtag cgcatcagac      720

gaggaaatcc aggacgtgtc agggacctgg tacctgaaag ccatgaccgt ggatttttgg      780

tgctccggca tccatgagga gtcagtcact cccatgaccc tgacaaccct agaaggtggg      840

aatctggagg ccaaagtgac aatggatatt gagggctttc tccaggagtt caaagccgtc      900

ctcgagaaga cagacgagcc tggaaagtat actgctgatg ggggaaaaca cgtagcctat      960

atcattcgat ctcgggtgaa ggatcattat atcttctatt ccgagggcga ctgccccggc     1020

cctgtgccag gtgtctggct agttgggagg gaccccaaga acaatctcga ggctctggag     1080

gacttcgaga aggcagctgg tgccagggga ttgagcactg agtctatcct tatcccacgc     1140

cagagcgaga cctcaagccc agggtccgac ggcggcggtg ggtccggcgg cggtggctcc     1200

gcgtccgatg aagaaatcca ggatgtgagc ggcacctggt atctgaaagc aatgaccgtt     1260

gacttctggt gctccggcat ccatgaagaa agcgtgaccc caatgacctt gaccacgctg     1320

gaaggcggta atttagaagc caaagtaact atggatatcg aaggcttcct gcaggaattt     1380

aaagcggtgc tggaaaaaac tgatgagcca ggtaaataca ccgccgacgg tggcaaacac     1440

gtggcctata ttatccgttc tcgtgtcaaa gaccattata tcttctactc tgaaggcgat     1500

tgccccggtc cggttccggg cgtctggctt gtcggtcgtg acccgaaaaa caacctggaa     1560

gcactcgaag acttcgaaaa agcggcaggc gcgcgtggtc tgtctaccga gagcatcctt     1620

atcccacgtc agagcgaaac ctccagccct ggttccgat                            1659


<210>  34
<211>  165
<212>  DNA
<213>  artificial

<220>
<223>  albumin binding domain

<400>  34
agcgctggtg ccgtcgacgc taactctctg gctgaagcta aagttctggc taaccgtgaa       60

ctggacaaat acggtgtttc cgactactac aaaaacctca tcaacaacgc taaaaccgtt      120

gaaggtgtta aagctctgat cgacgaaatt ctcgcagcac tgccg                      165


<210>  35
<211>  156
<212>  DNA
<213>  artificial

<220>
<223>  albumin binding domain

<400>  35
agcggcggcg gcggctctct ggctgaagct aaagaagcgg ctaacgcgga actggactct       60

tacggtgttt ccgactttta caaacgtctc atcgataaag ctaaaaccgt tgaaggtgtt      120

gaagctctga aagacgcgat tctcgcagca ctgccg                                156


<210>  36
<211>  681
<212>  DNA
<213>  artificial

<220>
<223>  Fc portion

<400>  36
gacaaaaccc acacctgccc accttgtcct gcccctgaac tgctgggagg accttctgtg       60

tttctgttcc caccaaaacc aaaagatacc ctgatgatct ctagaacccc tgaggtgaca      120

tgtgtggtgg tggatgtgtc tcatgaggac cctgaggtca aattcaactg gtacgtggat      180

ggagtggaag tccacaatgc caaaaccaag cctagagagg aacagtacaa ttcaacctac      240

agagtggtca gtgtgctgac tgtgctgcat caggattggc tgaatggcaa ggaatacaag      300

tgtaaagtct caaacaaggc cctgcctgct ccaattgaga aaacaatctc aaaggccaag      360

ggacagccta gggaacccca ggtctacacc ctgccacctt caagagagga aatgaccaaa      420

aaccaggtgt ccctgacatg cctggtcaaa ggcttctacc cttctgacat tgctgtggag      480

tgggagtcaa atggacagcc tgagaacaac tacaaaacaa ccccccctgt gctggattct      540

gatggctctt tctttctgta ctccaaactg actgtggaca agtctagatg gcagcagggg      600

aatgtctttt cttgctctgt catgcatgag gctctgcata accactacac tcagaaatcc      660

ctgtctctgt ctcctggcaa g                                                681


<210>  37
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  protein tag

<400>  37
agcgcttggt ctcacccgca gttcgaaaaa                                        30


<210>  38
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  synthetic linker

<400>  38
agcgacggtg gtggtggttc tggtggtggt ggatcg                                 36


<210>  39
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  synthetic linker

<400>  39
ggtggtggtg gttctggtgg tggtggatcg                                        30


<210>  40
<211>  6
<212>  DNA
<213>  artificial

<220>
<223>  synthetic linker

<400>  40
agcgac                                                                   6


<210>  41
<211>  152
<212>  PRT
<213>  human

<400>  41

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Cys Glu Gly Glu Leu His Gly Lys Pro Val Arg Gly Val Lys Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  42
<211>  151
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  42

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu Val Gly 
            100                 105                 110         


Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys Ala 
        115                 120                 125             


Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg Gln 
    130                 135                 140                 


Ser Glu Thr Ser Ser Pro Gly 
145                 150     


<210>  43
<211>  178
<212>  PRT
<213>  human

<400>  43

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  44
<211>  178
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  44

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Arg Val Glu Phe Gly Val Lys Thr Tyr Lys Tyr Gln Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Ala Ile 
                165                 170                 175     


Asp Gly 
        


<210>  45
<211>  178
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  45

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Arg Val Glu Phe Gly Val Lys Thr Arg Lys Tyr Arg Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Ala Ile 
                165                 170                 175     


Asp Gly 
        


<210>  46
<211>  178
<212>  PRT
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  46

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Arg Val Glu Phe Gly Val Lys Thr Tyr Lys Tyr Gln Ile 
65                  70                  75                  80  


Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      


Ile Lys Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Tyr Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Ala Ile 
                165                 170                 175     


Asp Gly 
        


<210>  47
<211>  456
<212>  DNA
<213>  human

<400>  47
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gacagggagt tccctgagat gaatctggaa tcggtgacac ccatgaccct cacgaccctg      120

gaagggggca acctggaagc caaggtcacc atgctgataa gtggccggtg ccaggaggtg      180

aaggccgtcc tggagaaaac tgacgagccg ggaaaataca cggccgacgg gggcaagcac      240

gtggcataca tcatcaggtc gcacgtgaag gaccactaca tcttttactg tgagggcgag      300

ctgcacggga agccggtccg aggggtgaag ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  48
<211>  453
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  48
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gatttttggt gttctgggat tcatgaggag tctgttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattg agggatttct tcaagagttt      180

aaggcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggtaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggagat      300

tgtcctggtc cggttccagg ggtgtggctc gtgggcagag accccaagaa caacctggaa      360

gccttggagg actttgagaa agccgcagga gcccgcggac tcagcacgga gagcatcctc      420

atccccaggc agagcgaaac cagctctcca ggg                                   453


<210>  49
<211>  534
<212>  DNA
<213>  human

<400>  49
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccaggggaag tggtatgtgg taggcctggc agggaatgca      120

attctcagag aagacaaaga cccgcaaaag atgtatgcca ccatctatga gctgaaagaa      180

gacaagagct acaatgtcac ctccgtcctg tttaggaaaa agaagtgtga ctactggatc      240

aggacttttg ttccaggttg ccagcccggc gagttcacgc tgggcaacat taagagttac      300

cctggattaa cgagttacct cgtccgagtg gtgagcacca actacaacca gcatgctatg      360

gtgttcttta agaaagtttc tcaaaacagg gagtacttca agatcaccct ctacgggaga      420

accaaggagc tgacttcgga actaaaggag aacttcatcc gcttctccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggc            534


<210>  50
<211>  534
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  50
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

ttgctgcgtg aggataagga tccgaggaaa atgacggcga ccatttacga gttgaaagaa      180

gataaatcat ataacgtcac ccgggtggag tttggggtta agacatacaa gtaccagatt      240

gggacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtatg      300

ccgggcatga catcattttt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtatgtgta tcagaaccgc gagtattttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc aggctatcga cggc            534


<210>  51
<211>  534
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  51
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtacgtag taggtgaggc cggaaatctg      120

attctgcgtg aggataagga tccgagaaaa atgactgcga ccatttacga gttgaaagaa      180

gataaatcat atgacgtcac cagggtggag tttggggtga agacgcgtaa gtaccggatt      240

gggacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtatg      300

ccgggcatga catcattttt ggtccgcgtc gtgagcacca actacaacca gcatgccatg      360

gtgttcttca agtacgtgta tcagaaccgc gagtattttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gctgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc aggctatcga cggc            534


<210>  52
<211>  534
<212>  DNA
<213>  artificial

<220>
<223>  lipocalin mutein

<400>  52
caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag       60

aacttccagg acaaccaatt ccatgggaaa tggtatgtcg tgggcgaggc cggaaatctt      120

ttgctgcgtg aggataagga tccgaggaaa atgacggcga ccatttacga gttgagagaa      180

gataaatcat atgacgtcac ccgggtggag tttggggtta agacatacaa gtaccagatt      240

gggacctttg tgccggggag ccagccgggc gagtttactt taggcggtat taaaagtatg      300

ccgggcatga catcattttt ggtccgcgtc gtgagcaccg actacaacca gcatgccatg      360

gtgttcttca agtatgtgta tcagaaccgc gagtattttg agatcacact gtacgggcgc      420

acgaaagaac tgacaagcga gttgaaggaa aattttatcc gcttttccaa atctctgggc      480

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc aggctatcga cggc            534


<210>  53
<211>  457
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody heavy chain

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile His Tyr Trp 
            100                 105                 110         


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  54
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody light chain

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Cys Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  55
<211>  446
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody heavy chain

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


His Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Glu Tyr Gly Thr Thr Asp Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Phe Thr Gly Thr Gly Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  56
<211>  219
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody light chain

<400>  56

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Lys His Ser 
            20                  25                  30          


Arg Gly Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ile Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  57
<211>  449
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody heavy chain

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Lys Thr Phe Trp Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Tyr Ile Gly Thr Gly Tyr Thr Glu Pro Asn Pro Lys Tyr 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ile Gly Gly Tyr Tyr Gly Asn Phe Asp Gln Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  58
<211>  219
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody light chain

<400>  58

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Ile Ser 
            20                  25                  30          


Gly Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Gln Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Tyr Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  59
<211>  447
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody heavy chain

<400>  59

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asn Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Tyr Tyr Lys Pro Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  60
<211>  217
<212>  PRT
<213>  artificial

<220>
<223>  reference antibody light chain

<400>  60

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Thr Asp Gly 
                85                  90                  95      


Leu Ser Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  61
<211>  451
<212>  PRT
<213>  artificial

<220>
<223>  benchmark antibody heavy chain

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  62
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  benchmark antibody light chain

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  63
<211>  619
<212>  PRT
<213>  artificial

<220>
<223>  fusion polypeptide

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr 
465                 470                 475                 480 


Leu Lys Ala Met Thr Val Asp Phe Trp Cys Ser Gly Ile His Glu Glu 
                485                 490                 495     


Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu 
            500                 505                 510         


Ala Lys Val Thr Met Asp Ile Glu Gly Phe Leu Gln Glu Phe Lys Ala 
        515                 520                 525             


Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly 
    530                 535                 540                 


Lys His Val Ala Tyr Ile Ile Arg Ser Arg Val Lys Asp His Tyr Ile 
545                 550                 555                 560 


Phe Tyr Ser Glu Gly Asp Cys Pro Gly Pro Val Pro Gly Val Trp Leu 
                565                 570                 575     


Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu 
            580                 585                 590         


Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro 
        595                 600                 605             


Arg Gln Ser Glu Thr Ser Ser Pro Gly Ser Asp 
    610                 615                 


<210>  64
<211>  644
<212>  PRT
<213>  artificial

<220>
<223>  fusion polypeptide

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
465                 470                 475                 480 


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys 
                485                 490                 495     


Trp Tyr Val Val Gly Glu Ala Gly Asn Leu Leu Leu Arg Glu Asp Lys 
            500                 505                 510         


Asp Pro Arg Lys Met Thr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
        515                 520                 525             


Ser Tyr Asp Val Thr Arg Val Glu Phe Gly Ala Lys Thr Tyr Lys Tyr 
    530                 535                 540                 


Gln Ile Gly Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
545                 550                 555                 560 


Gly Gly Ile Glu Ser Met Pro Gly Met Thr Ser Phe Leu Val Arg Val 
                565                 570                 575     


Val Ser Thr Asn Tyr Asn Gln His Ala Ile Val Phe Phe Lys Tyr Val 
            580                 585                 590         


Tyr Gln Asn Arg Glu Tyr Phe Glu Ile Thr Leu Tyr Gly Arg Thr Lys 
        595                 600                 605             


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
    610                 615                 620                 


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
625                 630                 635                 640 


Ala Ile Asp Gly 
                


<210>  65
<211>  1353
<212>  DNA
<213>  artificial

<220>
<223>  benchmark antibody heavy chain

<400>  65
gaagtgcagc tggtcgaaag tggtggtggt ctggtgcagc ccggtagaag tctgcgtctg       60

tcttgtgccg catctggttt tacattcgac gattacgcaa tgcattgggt gagacaggcc      120

cccggcaagg gactggagtg ggtctccgct atcacctgga acagcgggca tattgactac      180

gcagattccg tggaaggcag gttcacaatc tctcgggaca acgccaagaa tagtctgtat      240

ctgcagatga attcactgag ggccgaggat accgccgtgt actattgcgc taaagtctct      300

tatctgtcta ccgcatcatc tctggattac tggggtcagg gaacactggt cactgtctcc      360

tctgctagca caaagggccc tagtgtgttt cctctggctc cctcttccaa atccacttct      420

ggtggcactg ctgctctggg atgcctggtg aaggattact ttcctgaacc tgtgactgtc      480

tcatggaact ctggtgctct gacttctggt gtccacactt tccctgctgt gctgcagtct      540

agtggactgt actctctgtc atctgtggtc actgtgccct cttcatctct gggaacccag      600

acctacattt gtaatgtgaa ccacaaacca tccaacacta aagtggacaa aaaagtggaa      660

cccaaatcct gtgacaaaac ccacacctgc ccaccttgtc ctgcccctga actgctggga      720

ggaccttctg tgtttctgtt cccaccaaaa ccaaaagata ccctgatgat ctctagaacc      780

cctgaggtga catgtgtggt ggtggatgtg tctcatgagg accctgaggt caaattcaac      840

tggtacgtgg atggagtgga agtccacaat gccaaaacca agcctagaga ggaacagtac      900

aattcaacct acagagtggt cagtgtgctg actgtgctgc atcaggattg gctgaatggc      960

aaggaataca agtgtaaagt ctcaaacaag gccctgcctg ctccaattga gaaaacaatc     1020

tcaaaggcca agggacagcc tagggaaccc caggtctaca ccctgccacc ttcaagagag     1080

gaaatgacca aaaaccaggt gtccctgaca tgcctggtca aaggcttcta cccttctgac     1140

attgctgtgg agtgggagtc aaatggacag cctgagaaca actacaaaac aaccccccct     1200

gtgctggatt ctgatggctc tttctttctg tactccaaac tgactgtgga caagtctaga     1260

tggcagcagg ggaatgtctt ttcttgctct gtcatgcatg aggctctgca taaccactac     1320

actcagaaat ccctgtctct gtctcctggc aaa                                  1353


<210>  66
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  benchmark antibody light chain

<400>  66
gacatccaga tgacccagag cccaagttcc ctgagcgcaa gcgtcggaga tcgtgtgact       60

attacctgta gagcaagcca gggcatcaga aactacctgg catggtatca gcagaagccc      120

ggtaaagccc ctaagctgct gatctacgcc gcttccactc tgcagtctgg cgtgccaagc      180

aggttctctg gcagtggatc agggaccgac tttaccctga caatttccag cctgcagccc      240

gaggatgtcg ctacatacta ttgccagcgg tacaatcggg caccttatac attcggtcag      300

gggactaaag tggaaatcaa gagaactgtc gcggcgcctt ctgtgttcat tttcccccca      360

tctgatgaac agctgaaatc tggcactgct tctgtggtct gtctgctgaa caacttctac      420

cctagagagg ccaaagtcca gtggaaagtg gacaatgctc tgcagagtgg gaattcccag      480

gaatctgtca ctgagcagga ctctaaggat agcacatact ccctgtcctc tactctgaca      540

ctgagcaagg ctgattacga gaaacacaaa gtgtacgcct gtgaagtcac acatcagggg      600

ctgtctagtc ctgtgaccaa atccttcaat aggggagagt gc                         642


<210>  67
<211>  1857
<212>  DNA
<213>  artificial

<220>
<223>  fusion polypeptide

<400>  67
gaagtgcagc tggtcgaaag tggtggtggt ctggtgcagc ccggtagaag tctgcgtctg       60

tcttgtgccg catctggttt tacattcgac gattacgcaa tgcattgggt gagacaggcc      120

cccggcaagg gactggagtg ggtctccgct atcacctgga acagcgggca tattgactac      180

gcagattccg tggaaggcag gttcacaatc tctcgggaca acgccaagaa tagtctgtat      240

ctgcagatga attcactgag ggccgaggat accgccgtgt actattgcgc taaagtctct      300

tatctgtcta ccgcatcatc tctggattac tggggtcagg gaacactggt cactgtctcc      360

tctgctagca caaagggccc tagtgtgttt cctctggctc cctcttccaa atccacttct      420

ggtggcactg ctgctctggg atgcctggtg aaggattact ttcctgaacc tgtgactgtc      480

tcatggaact ctggtgctct gacttctggt gtccacactt tccctgctgt gctgcagtct      540

agtggactgt actctctgtc atctgtggtc actgtgccct cttcatctct gggaacccag      600

acctacattt gtaatgtgaa ccacaaacca tccaacacta aagtggacaa aaaagtggaa      660

cccaaatcct gtgacaaaac ccacacctgc ccaccttgtc ctgcccctga actgctggga      720

ggaccttctg tgtttctgtt cccaccaaaa ccaaaagata ccctgatgat ctctagaacc      780

cctgaggtga catgtgtggt ggtggatgtg tctcatgagg accctgaggt caaattcaac      840

tggtacgtgg atggagtgga agtccacaat gccaaaacca agcctagaga ggaacagtac      900

aattcaacct acagagtggt cagtgtgctg actgtgctgc atcaggattg gctgaatggc      960

aaggaataca agtgtaaagt ctcaaacaag gccctgcctg ctccaattga gaaaacaatc     1020

tcaaaggcca agggacagcc tagggaaccc caggtctaca ccctgccacc ttcaagagag     1080

gaaatgacca aaaaccaggt gtccctgaca tgcctggtca aaggcttcta cccttctgac     1140

attgctgtgg agtgggagtc aaatggacag cctgagaaca actacaaaac aaccccccct     1200

gtgctggatt ctgatggctc tttctttctg tactccaaac tgactgtgga caagtctaga     1260

tggcagcagg ggaatgtctt ttcttgctct gtcatgcatg aggctctgca taaccactac     1320

actcagaaat ccctgtctct gtctcctggc aaaggcggcg gaggatccgg cggaggaggt     1380

agcggcggag gaggtagcgc atcagacgag gaaatccagg acgtgtcagg gacctggtac     1440

ctgaaagcca tgaccgtgga tttttggtgc tccggcatcc atgaggagtc agtcactccc     1500

atgaccctga caaccctaga aggtgggaat ctggaggcca aagtgacaat ggatattgag     1560

ggctttctcc aggagttcaa agccgtcctc gagaagacag acgagcctgg aaagtatact     1620

gctgatgggg gaaaacacgt agcctatatc attcgatctc gggtgaagga tcattatatc     1680

ttctattccg agggcgactg ccccggccct gtgccaggtg tctggctagt tgggagggac     1740

cccaagaaca atctcgaggc tctggaggac ttcgagaagg cagctggtgc caggggattg     1800

agcactgagt ctatccttat cccacgccag agcgagacct caagcccagg gtccgac        1857


<210>  68
<211>  1932
<212>  DNA
<213>  artificial

<220>
<223>  fusion polypeptide

<400>  68
gaagtgcagc tggtcgaaag tggtggtggt ctggtgcagc ccggtagaag tctgcgtctg       60

tcttgtgccg catctggttt tacattcgac gattacgcaa tgcattgggt gagacaggcc      120

cccggcaagg gactggagtg ggtctccgct atcacctgga acagcgggca tattgactac      180

gcagattccg tggaaggcag gttcacaatc tctcgggaca acgccaagaa tagtctgtat      240

ctgcagatga attcactgag ggccgaggat accgccgtgt actattgcgc taaagtctct      300

tatctgtcta ccgcatcatc tctggattac tggggtcagg gaacactggt cactgtctcc      360

tctgctagca caaagggccc tagtgtgttt cctctggctc cctcttccaa atccacttct      420

ggtggcactg ctgctctggg atgcctggtg aaggattact ttcctgaacc tgtgactgtc      480

tcatggaact ctggtgctct gacttctggt gtccacactt tccctgctgt gctgcagtct      540

agtggactgt actctctgtc atctgtggtc actgtgccct cttcatctct gggaacccag      600

acctacattt gtaatgtgaa ccacaaacca tccaacacta aagtggacaa aaaagtggaa      660

cccaaatcct gtgacaaaac ccacacctgc ccaccttgtc ctgcccctga actgctggga      720

ggaccttctg tgtttctgtt cccaccaaaa ccaaaagata ccctgatgat ctctagaacc      780

cctgaggtga catgtgtggt ggtggatgtg tctcatgagg accctgaggt caaattcaac      840

tggtacgtgg atggagtgga agtccacaat gccaaaacca agcctagaga ggaacagtac      900

aattcaacct acagagtggt cagtgtgctg actgtgctgc atcaggattg gctgaatggc      960

aaggaataca agtgtaaagt ctcaaacaag gccctgcctg ctccaattga gaaaacaatc     1020

tcaaaggcca agggacagcc tagggaaccc caggtctaca ccctgccacc ttcaagagag     1080

gaaatgacca aaaaccaggt gtccctgaca tgcctggtca aaggcttcta cccttctgac     1140

attgctgtgg agtgggagtc aaatggacag cctgagaaca actacaaaac aaccccccct     1200

gtgctggatt ctgatggctc tttctttctg tactccaaac tgactgtgga caagtctaga     1260

tggcagcagg ggaatgtctt ttcttgctct gtcatgcatg aggctctgca taaccactac     1320

actcagaaat ccctgtctct gtctcctggc aaaggcggcg gaggatccgg gggtggggga     1380

agcggcggag gaggtagcca ggattcaacc agcgatctga ttccagcacc gccactgtcg     1440

aaagtgccac tgcaacaaaa ctttcaagat aaccagtttc acggcaagtg gtatgtggtc     1500

ggggaggccg gtaacctgct gctgagggaa gacaaagatc cacggaaaat gaccgccacc     1560

atctacgagc tgaaagagga taagtcctac gacgtgactc gggtggagtt cggcgcaaaa     1620

acctacaagt accagatcgg caccttcgtg cccggctctc agcctggcga gtttaccctg     1680

ggcggcatcg aatctatgcc cggcatgacc agctttctcg tgcgggtggt gtccaccaac     1740

tacaaccagc acgccatcgt gttcttcaaa tacgtgtacc agaaccgcga gtacttcgag     1800

atcaccctgt acggccggac caaagagctg acctccgaac tgaaagagaa cttcatccgg     1860

ttctccaagt ccctgggcct gcccgagaac cacatcgtgt tccccgtgcc tatcgaccag     1920

gccatcgacg gc                                                         1932


