
                                SEQUENCE LISTING

<110> Blain, Stacy W.

<120> Compositions Targeting the Interaction
  Domain between p27Kip1 and Brk and Methods of Use Thereof to
  Prevent p27 Y Phosphorylation and cdk4 Activity
  

<130> 5168-P06009WO00

<140> PCT/US2015/031128   
<141> 2015-05-15  

<150> 61/994,087          
<151> 2015-05-14  

<150> 62/113,166          
<151> 2015-02-06  

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 198
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met
 1               5                  10                  15      
Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu
            20                  25                  30          
Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His
        35                  40                  45              
Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe
    50                  55                  60                  
Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu
65                  70                  75                  80  
Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys
                85                  90                  95      
Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser
            100                 105                 110         
Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr
        115                 120                 125             
His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu
    130                 135                 140                 
Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser
145                 150                 155                 160 
Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp
                165                 170                 175     
Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly
            180                 185                 190         
Leu Arg Arg Arg Gln Thr
        195             


<210> 2
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> SH3 domain of Brk

<400> 2
Lys Tyr Val Gly Leu Trp Asp Phe Lys Ser Arg Thr Asp Glu Glu Leu
 1               5                  10                  15      
Ser Phe Arg Ala Gly Asp Val Phe His Val Ala Arg Lys Glu Glu Gln
            20                  25                  30          
Trp Trp Trp Ala Thr Leu Leu Asp Glu Ala Gly Gly Ala Val Ala Gln
        35                  40                  45              
Gly Leu Tyr Tyr Val Pro His Asn Tyr Leu Ala Glu Arg
    50                  55                  60      


<210> 3
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> SH3 domain of Src

<400> 3
Thr Phe Val Ala Leu Tyr Asp Tyr Glu Ser Arg Thr Glu Thr Asp Leu
 1               5                  10                  15      
Ser Phe Lys Lys Gly Glu Arg Leu Gln Ile Val Asn Asn Thr Glu Gly
            20                  25                  30          
Asp Trp Trp Leu Ala His Ser Leu Thr Thr Gly Gln Thr Gly Tyr Ile
        35                  40                  45              
Pro Ser Asn Tyr Val Ala Pro Ser
    50                  55      


<210> 4
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Proline-rich sequence

<220> 
<221> VARIANT        
<222> (2)...(3)
<223> Xaa = any amino acid

<400> 4
Pro Xaa Xaa Pro
 1              


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> K1 site of P27

<400> 5
Arg Pro Pro Arg Pro Pro Lys Gly Ala Cys Lys
 1               5                  10      


<210> 6
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 6
ggcctcgagc tagctctcct gcgccg                                      26

<210> 7
<211> 65
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 7
ggggtctaga gccaccatgg actacaagga cgacgatgac aagcgcaagt ggaatttcga 60
ttttc                                                             65

<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 8
aaaatctggc accacacctt ctac                                        24

<210> 9
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 9
tagcacagcc tggatagcaa cg                                          22

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 10
ccaagtatgt gggcctctgg                                             20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 11
aaagaaccac ggttccgact                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 12
gacggtggag tcggaacctg                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 13
tagttcacaa gctcgggcag                                             20

<210> 14
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> K1

<400> 14
Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys Gly Ala Cys Lys
 1               5                  10                  15      
Val Pro
        


<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> K2

<400> 15
Asp Val Ser Gly Ser Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala
 1               5                  10                  15      


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> K3

<400> 16
Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly Leu Arg Arg Arg Gln
 1               5                  10                  15      

