                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  Treating Chronic Myelogenous Leukemia (CML)

<130>  07917-0374WO1

<140>  PCT/US2015/030908
<141>  2015-05-14

<150>  61/994,689
<151>  2014-05-16

<150>  62/032,117
<151>  2014-08-01

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically generated primer

<400>  1
atctgggtcc tgtcatcagc                                                   20


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically generated primer

<400>  2
gctgccttgg attggtctg                                                    19


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically generated primer

<400>  3
aactagtaga agaccaggag                                                   20


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically generated Primer

<400>  4
cgaaagtctc tctgactgc                                                    19


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  5
cacctcaatg acagtggtca g                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  6
tggatcggat acccatagca g                                                 21


<210>  7
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  7
tccagctcct cctactgg                                                     18


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  8
cagaatactt gccattcacc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  9
aggtggcgtt ggatcaacaa                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  10
ttaggccaat ggtcgcacag                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  11
ctgcacacca ctcctaaggc                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  12
caggcgcttt ttggtcagt                                                    19


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  13
atggatgctg atctctcaca cc                                                22


<210>  14
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  14
ccatttcctt tgtagcgagt tcc                                               23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  15
cctggtgttg tggaagtcac a                                                 21


<210>  16
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  16
gctcaacgaa cccaccatc                                                    19


<210>  17
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  17
gctgattcca actgcttgaa aac                                               23


<210>  18
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  18
cagttttctt caggagatag aagc                                              24


<210>  19
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  19
ccaaatgaag gctacttgga gt                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  20
tagagggtgt tagcgatctc g                                                 21


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  21
atcgggctaa tcgagaaaaa gtc                                               23


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  22
tgctggtcta gttcttgctc c                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  23
agccggtcac ccatctatga a                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  24
tagagacaca tggtcggaca t                                                 21


<210>  25
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  25
gctcactcag ctccaacc                                                     18


<210>  26
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  26
tcaccagcct tggattcg                                                     18


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  27
ttctggtctc cgagtcactc a                                                 21


<210>  28
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  28
gccgtccact taatagggaa ct                                                22


<210>  29
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  29
cgcctgtctt cgtcacgtc                                                    19


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  30
ctgctgaaag gtgagcaagt                                                   20


<210>  31
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  31
gtggagtgcc agatgttgc                                                    19


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  32
atcgatccac tgaatatgcg                                                   20


<210>  33
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  33
gtgacttgat gttccacatt cag                                               23


<210>  34
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  34
attgtccagt ttcagatctc tatag                                             25


<210>  35
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  35
cacgccggaa aagcgagc                                                     18


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  36
ggatcagtcg cagaatttcc                                                   20


<210>  37
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  37
gactttgtgg acgaagtaag agc                                               23


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  38
gctttccaga ggttcagtct c                                                 21


<210>  39
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  39
ctgcaagcag cagtgagg                                                     18


<210>  40
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  40
aaccggcagg aagactgag                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  41
gaccccaaga ttcagaagg                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  42
tccggggaat cttctatcc                                                    19


<210>  43
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  43
tcgttctcgc ccgcaattta g                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  44
gataaggacg gctccgtttt g                                                 21


<210>  45
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  45
tcggcttcta taacttctgc ct                                                22


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  46
ctgttgcact gggctaggag                                                   20


<210>  47
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  47
tgcctatccg ctgcatcc                                                     18


<210>  48
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  48
ttcatggggc agcgattagc                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  49
atagcagcgg caatacgtgg                                                   20


<210>  50
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  50
gaagacacat tagaggcagt gaa                                               23


<210>  51
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  51
gaagcagggc tactacaacc a                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  52
cggcctcatt gttatgcagg t                                                 21


<210>  53
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  53
gagaggggaa cagcgagag                                                    19


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  54
cagtctcagg ccagcttctc                                                   20


<210>  55
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  55
tagtcctccc agcaaatgta ag                                                22


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  56
gtcttcctcc tcctgcatag                                                   20


<210>  57
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  57
ttctgtctgc cctttattcc tcc                                               23


<210>  58
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  58
tcttacttct ctcacggcat ct                                                22


<210>  59
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  59
aagctggatg tccattatgc tc                                                22


<210>  60
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  60
tctgtaggag gtgacgtctg                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  61
tctggatgcc agggtgattc                                                   20


<210>  62
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  62
tattcatcca ggaaatgtaa gcag                                              24


<210>  63
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  63
gaaactggga ttttcaccaa gg                                                22


<210>  64
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  64
tcctgaagat acttcagttt ctc                                               23


<210>  65
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  65
tatgtgtata tctacaggtc tgac                                              24


<210>  66
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  66
accacacttg gaagagtttt gc                                                22


<210>  67
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  67
gtaattttga tattgtctct ggaac                                             25


<210>  68
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  68
cttcttttcg gtataatctg aagc                                              24


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  69
ctcaccctat gccattgtgc                                                   20


<210>  70
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  70
cgaaagcact cttctgtttc ac                                                22


<210>  71
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  71
tgcctttgag catcagacag                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  72
tactggtcgc agcagaattg                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  73
gtgatgacct tggcacagag                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  74
cattccagca gcagcacatc                                                   20


<210>  75
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  75
acatctgaga ttgcagtgag tg                                                22


<210>  76
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  76
tactactatc cagcagtgca g                                                 21


<210>  77
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  77
tgggtgtcca aggtctctc                                                    19


<210>  78
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  78
ctcccactga ataggtgctt tg                                                22


<210>  79
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  79
ctgccagtgt tctaggaaac tac                                               23


<210>  80
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  80
atgtgagtaa cggccactag g                                                 21


<210>  81
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  81
tgaggacgca ggagtgaac                                                    19


<210>  82
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  82
cgtcctttgt aagactgaag tc                                                22


<210>  83
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  83
tccggcacga tgaagttcaa t                                                 21


<210>  84
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  84
tacgctcacc gtcaggtagg                                                   20


<210>  85
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  85
acgacgtaga cggcaatgg                                                    19


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  86
ccgcttttct ggggtgtttt                                                   20


<210>  87
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  87
cttctgctca gggttttcaa g                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  88
atgtcttctc tctccaaggt g                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  89
agtatgactg tagtgcccta c                                                 21


<210>  90
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  90
caggacctgt ccaggcac                                                     18


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  91
ctgcttttct gcgagccaac                                                   20


<210>  92
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  92
tgtcgttttg atcggacatc c                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  93
gtatccgccc tcaattcata g                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  94
ctccgttttg ccttccaatg c                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  95
cagcgttggt ttttgtctcc c                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  96
gaggagagcg tagaacatca g                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  97
cccggcttcg actacaagtt c                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  98
tcagggcatt tgaagactcc t                                                 21


<210>  99
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  99
tgctacaact tcaggaaaag ctc                                               23


<210>  100
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  100
gtctggagca tctgtaaatc atc                                               23


<210>  101
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  101
cccgatgcca tcattgtgat c                                                 21


<210>  102
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  102
gtagggagtc gagaggctg                                                    19


<210>  103
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  103
ataggttaac gccaccatgt cgtccggcac gatga                                  35


<210>  104
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  104
ataggaattc ctacagttgc aattccggtg a                                      31


<210>  105
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  105
atagacgcgt ttcttggctt tatatatctt gtgg                                   34


<210>  106
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  106
atagacgcgt caaagtggat ctctgctgtc                                        30


<210>  107
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  107
aggaggagaa gcaagaggag                                                   20


<210>  108
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  108
ccgaccgtcc cttccaag                                                     18


<210>  109
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  109
gacctttcct gctctatgtg                                                   20


<210>  110
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  110
ctgcagaggc taattacaca g                                                 21


<210>  111
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  111
catagcagcg taggctaaaa                                                   20


<210>  112
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  112
cggaagaaat tgcctcttct ag                                                22


<210>  113
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  113
ataggctagc gttctgaaca gggccttaga g                                      31


<210>  114
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetically generated primer

<400>  114
atagaagctt gatgcggacc ctcaaatagc                                        30


<210>  115
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Glu Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


