                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
       YAN, Yajun
       LIN, Yuheng
 
<120>  MICROBIAL APPROACH FOR THE PRODUCTION OF 5-HYDROXYTRYPTOPHAN

<130>  235.02480201

<150>  US 61/994,413
<151>  2014-05-16

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  296
<212>  PRT
<213>  Xanthomonas campestris

<400>  1

Met Asn Thr Ala Pro Arg Arg Val Glu Asn Gln Leu Thr Asp Lys Gly 
1               5                   10                  15      


Tyr Val Pro Val Tyr Thr Thr Ala Val Val Glu Gln Pro Trp Asp Gly 
            20                  25                  30          


Tyr Ser Ala Asp Asp His Ala Thr Trp Gly Thr Leu Tyr Arg Arg Gln 
        35                  40                  45              


Arg Ala Leu Leu Val Gly Arg Ala Cys Asp Glu Phe Leu Gln Ala Gln 
    50                  55                  60                  


Asp Ala Met Gly Met Asp Asp Thr Gln Ile Pro Arg Phe Asp Ala Leu 
65                  70                  75                  80  


Asn Ala Val Leu Gln Ala Thr Thr Gly Trp Thr Leu Val Gly Val Glu 
                85                  90                  95      


Gly Leu Leu Pro Glu Leu Asp Phe Phe Asp His Leu Ala Asn Arg Arg 
            100                 105                 110         


Phe Pro Val Thr Trp Trp Ile Arg Arg Pro Asp Gln Ile Asp Tyr Ile 
        115                 120                 125             


Ala Glu Pro Asp Leu Phe His Asp Leu Phe Gly His Val Pro Leu Leu 
    130                 135                 140                 


Met Asn Pro Leu Phe Ala Asp Phe Met Gln Ala Tyr Gly Arg Gly Gly 
145                 150                 155                 160 


Val Lys Ala His Gly Ile Gly Pro Asp Ala Leu Gln Asn Leu Thr Arg 
                165                 170                 175     


Leu Tyr Trp Tyr Thr Val Glu Phe Gly Leu Ile Ala Thr Pro Gln Gly 
            180                 185                 190         


Leu Arg Ile Tyr Gly Ala Gly Ile Val Ser Ser Lys Gly Glu Ser Leu 
        195                 200                 205             


His Ser Leu Glu Ser Ala Ala Pro Asn Arg Val Gly Phe Asp Leu Gln 
    210                 215                 220                 


Arg Val Met Arg Thr Arg Tyr Arg Ile Asp Ser Phe Gln Lys Thr Tyr 
225                 230                 235                 240 


Phe Val Ile Asp Ser Phe Thr Gln Leu Met Asp Ala Thr Ala Pro Asp 
                245                 250                 255     


Phe Thr Pro Ile Tyr Ala Ala Leu Ala Gln Gln Pro Gln Val Pro Ala 
            260                 265                 270         


Gly Glu Val Leu Ala Thr Asp His Val Leu Gln Arg Gly Ser Gly Glu 
        275                 280                 285             


Gly Trp Ser Arg Asp Gly Asp Val 
    290                 295     


<210>  2
<211>  262
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  2

Met Lys Thr Thr Gln Tyr Val Ala Arg Gln Pro Asp Asp Asn Gly Phe 
1               5                   10                  15      


Ile His Tyr Pro Glu Thr Glu His Gln Val Trp Asn Thr Leu Ile Thr 
            20                  25                  30          


Arg Gln Leu Lys Val Ile Glu Gly Arg Ala Cys Gln Glu Tyr Leu Asp 
        35                  40                  45              


Gly Ile Glu Gln Leu Gly Leu Pro His Glu Arg Ile Pro Gln Leu Asp 
    50                  55                  60                  


Glu Ile Asn Arg Val Leu Gln Ala Thr Thr Gly Trp Arg Val Ala Arg 
65                  70                  75                  80  


Val Pro Ala Leu Ile Pro Phe Gln Thr Phe Phe Glu Leu Leu Ala Ser 
                85                  90                  95      


Gln Gln Phe Pro Val Ala Thr Phe Ile Arg Thr Pro Glu Glu Leu Asp 
            100                 105                 110         


Tyr Leu Gln Glu Pro Asp Ile Phe His Glu Ile Phe Gly His Cys Pro 
        115                 120                 125             


Leu Leu Thr Asn Pro Trp Phe Ala Glu Phe Thr His Thr Tyr Gly Lys 
    130                 135                 140                 


Leu Gly Leu Lys Ala Ser Lys Glu Glu Arg Val Phe Leu Ala Arg Leu 
145                 150                 155                 160 


Tyr Trp Met Thr Ile Glu Phe Gly Leu Val Glu Thr Asp Gln Gly Lys 
                165                 170                 175     


Arg Ile Tyr Gly Gly Gly Ile Leu Ser Ser Pro Lys Glu Thr Val Tyr 
            180                 185                 190         


Ser Leu Ser Asp Glu Pro Leu His Gln Ala Phe Asn Pro Leu Glu Ala 
        195                 200                 205             


Met Arg Thr Pro Tyr Arg Ile Asp Ile Leu Gln Pro Leu Tyr Phe Val 
    210                 215                 220                 


Leu Pro Asp Leu Lys Arg Leu Phe Gln Leu Ala Gln Glu Asp Ile Met 
225                 230                 235                 240 


Ala Leu Val His Glu Ala Met Arg Leu Gly Leu His Ala Pro Leu Phe 
                245                 250                 255     


Pro Pro Lys Gln Ala Ala 
            260         


<210>  3
<211>  263
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  3

Met Lys Gln Thr Gln Tyr Val Ala Arg Glu Pro Asp Ala Gln Gly Phe 
1               5                   10                  15      


Ile Asp Tyr Pro Pro Glu Glu His Ala Val Trp Asn Thr Leu Ile Thr 
            20                  25                  30          


Arg Gln Leu Lys Val Ile Glu Gly Arg Ala Cys Gln Glu Tyr Leu Asp 
        35                  40                  45              


Gly Ile Asp Lys Leu Gly Leu Pro His Asp Arg Ile Pro Gln Leu Gly 
    50                  55                  60                  


Glu Ile Asn Lys Val Leu Gly Glu Thr Thr Gly Trp Gln Val Ala Arg 
65                  70                  75                  80  


Val Pro Ala Leu Ile Pro Phe Gln Thr Phe Phe Glu Leu Leu Ala Ser 
                85                  90                  95      


Lys Arg Phe Pro Val Ala Thr Phe Ile Arg Thr Arg Glu Glu Leu Asp 
            100                 105                 110         


Tyr Leu Gln Glu Pro Asp Ile Phe His Glu Ile Phe Gly His Cys Pro 
        115                 120                 125             


Leu Leu Thr Asn Pro Trp Phe Ala Glu Phe Thr His Thr Tyr Gly Lys 
    130                 135                 140                 


Leu Gly Leu Gln Ala Thr Lys Glu Glu Arg Val Tyr Leu Ala Arg Leu 
145                 150                 155                 160 


Tyr Trp Met Thr Ile Glu Phe Gly Leu Val Asp Thr Pro Ala Gly Arg 
                165                 170                 175     


Arg Ile Tyr Gly Gly Gly Ile Leu Ser Ser Pro Lys Glu Thr Val Tyr 
            180                 185                 190         


Ser Leu Ser Glu Glu Pro Glu His Gln Ala Phe Asp Pro Leu Glu Ala 
        195                 200                 205             


Met Arg Thr Pro Tyr Arg Ile Asp Ile Leu Gln Pro Ile Tyr Phe Thr 
    210                 215                 220                 


Leu Pro Asn Leu Lys Arg Leu Phe Asp Leu Ala His Glu Asp Ile Met 
225                 230                 235                 240 


Ala Leu Val His Gln Gly Met Gln Leu Gly Leu His Ala Pro Lys Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Ala Ala 
            260             


<210>  4
<211>  262
<212>  PRT
<213>  Pseudomonas putida

<400>  4

Met Lys Gln Thr Gln Tyr Val Ala Arg Glu Pro Asp Ala His Gly Phe 
1               5                   10                  15      


Ile Asp Tyr Pro Gln Gln Glu His Ala Val Trp Asn Thr Leu Ile Thr 
            20                  25                  30          


Arg Gln Leu Lys Val Ile Glu Gly Arg Ala Cys Gln Glu Tyr Leu Asp 
        35                  40                  45              


Gly Ile Asp Gln Leu Lys Leu Pro His Asp Arg Ile Pro Gln Leu Gly 
    50                  55                  60                  


Glu Ile Asn Lys Val Leu Gly Ala Thr Thr Gly Trp Gln Val Ala Arg 
65                  70                  75                  80  


Val Pro Ala Leu Ile Pro Phe Gln Thr Phe Phe Glu Leu Leu Ala Ser 
                85                  90                  95      


Lys Arg Phe Pro Val Ala Thr Phe Ile Arg Thr Pro Glu Glu Leu Asp 
            100                 105                 110         


Tyr Leu Gln Glu Pro Asp Ile Phe His Glu Ile Phe Gly His Cys Pro 
        115                 120                 125             


Leu Leu Thr Asn Pro Trp Phe Ala Glu Phe Thr His Thr Tyr Gly Lys 
    130                 135                 140                 


Leu Gly Leu Ala Ala Thr Lys Glu Gln Arg Val Tyr Leu Ala Arg Leu 
145                 150                 155                 160 


Tyr Trp Met Thr Ile Glu Phe Gly Leu Met Glu Thr Ala Gln Gly Arg 
                165                 170                 175     


Lys Ile Tyr Gly Gly Gly Ile Leu Ser Ser Pro Lys Glu Thr Val Tyr 
            180                 185                 190         


Ser Leu Ser Asp Glu Pro Glu His Gln Ala Phe Asp Pro Ile Glu Ala 
        195                 200                 205             


Met Arg Thr Pro Tyr Arg Ile Asp Ile Leu Gln Pro Val Tyr Phe Val 
    210                 215                 220                 


Leu Pro Asn Met Lys Arg Leu Phe Asp Leu Ala His Glu Asp Ile Met 
225                 230                 235                 240 


Gly Met Val His Lys Ala Met Gln Leu Gly Leu His Ala Pro Lys Phe 
                245                 250                 255     


Pro Pro Lys Val Ala Ala 
            260         


<210>  5
<211>  309
<212>  PRT
<213>  Ralstonia eutropha

<400>  5

Met Ser Ile Ala Thr Ala Thr Glu Ala Pro Gly Ala Phe Gln Gly Thr 
1               5                   10                  15      


Leu Thr Asp Lys Leu Lys Glu Gln Phe Asp Ala Gly Leu Leu Ser Gly 
            20                  25                  30          


Gln Glu Leu Arg Pro Asp Phe Thr Ile Ala Gln Pro Val His Arg Tyr 
        35                  40                  45              


Thr Ser Thr Asp His Ala Ile Trp Arg Lys Leu Tyr Glu Arg Gln Ala 
    50                  55                  60                  


Ala Met Leu Gln Gly Arg Val Ser Asp Glu Phe Leu Gln Gly Leu Ala 
65                  70                  75                  80  


Thr Leu Gly Met Asp Lys Asp Arg Val Pro Asp Phe Asp Gln Leu Asn 
                85                  90                  95      


Glu Thr Leu Met Arg Ala Thr Gly Trp Gln Val Val Ala Val Pro Gly 
            100                 105                 110         


Leu Val Pro Asp Gln Val Phe Phe Glu His Leu Ala Asn Arg Arg Phe 
        115                 120                 125             


Pro Ala Ser Trp Trp Met Arg Lys Pro Glu Gln Leu Asp Tyr Leu Gln 
    130                 135                 140                 


Glu Pro Asp Cys Phe His Asp Val Phe Gly His Val Pro Leu Leu Ile 
145                 150                 155                 160 


Asn Pro Val Phe Ala Asp Tyr Met Glu Ala Tyr Gly Lys Gly Gly Leu 
                165                 170                 175     


Lys Ala Asn Gly Leu Gly Ala Leu Asp Met Leu Ser Arg Leu Tyr Trp 
            180                 185                 190         


Tyr Thr Val Glu Phe Gly Leu Ile Arg Thr Ala Gln Gly Leu Arg Ile 
        195                 200                 205             


Tyr Gly Ala Gly Ile Leu Ser Ser Gln Gly Glu Ser Ile Tyr Ser Leu 
    210                 215                 220                 


Asp Ser Ala Ser Pro Asn Arg Ile Gly Phe Asp Val Arg Arg Ile Met 
225                 230                 235                 240 


Arg Thr Arg Tyr Arg Ile Asp Thr Phe Gln Lys Thr Tyr Phe Val Ile 
                245                 250                 255     


Asp Ser Phe Glu Gln Leu Phe Asp Ala Thr Arg Pro Asp Phe Ala Pro 
            260                 265                 270         


Leu Tyr Glu Glu Leu Arg Ala Gln Pro Thr Leu Gly Ala Gly Asp Val 
        275                 280                 285             


Ala Pro Gly Asp Gln Val Leu Asn Val Gly Thr Arg Glu Gly Trp Ala 
    290                 295                 300                 


Asp Thr Glu Asp Ile 
305                 


<210>  6
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Pro Ala Met Met Met Phe Ser Ser Lys Tyr Trp Ala Arg Arg 
1               5                   10                  15      


Gly Phe Ser Leu Asp Ser Ala Val Pro Glu Glu His Gln Leu Leu Gly 
            20                  25                  30          


Ser Ser Thr Leu Asn Lys Pro Asn Ser Gly Lys Asn Asp Asp Lys Gly 
        35                  40                  45              


Asn Lys Gly Ser Ser Lys Arg Glu Ala Ala Thr Glu Ser Gly Lys Thr 
    50                  55                  60                  


Ala Val Val Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Val Lys Ala 
65                  70                  75                  80  


Leu Arg Leu Phe Gln Glu Lys Arg Val Asn Met Val His Ile Glu Ser 
                85                  90                  95      


Arg Lys Ser Arg Arg Arg Ser Ser Glu Val Glu Ile Phe Val Asp Cys 
            100                 105                 110         


Glu Cys Gly Lys Thr Glu Phe Asn Glu Leu Ile Gln Leu Leu Lys Phe 
        115                 120                 125             


Gln Thr Thr Ile Val Thr Leu Asn Pro Pro Glu Asn Ile Trp Thr Glu 
    130                 135                 140                 


Glu Glu Glu Leu Glu Asp Val Pro Trp Phe Pro Arg Lys Ile Ser Glu 
145                 150                 155                 160 


Leu Asp Lys Cys Ser His Arg Val Leu Met Tyr Gly Ser Glu Leu Asp 
                165                 170                 175     


Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Gln Arg Arg Lys 
            180                 185                 190         


Tyr Phe Val Asp Val Ala Met Gly Tyr Lys Tyr Gly Gln Pro Ile Pro 
        195                 200                 205             


Arg Val Glu Tyr Thr Glu Glu Glu Thr Lys Thr Trp Gly Val Val Phe 
    210                 215                 220                 


Arg Glu Leu Ser Lys Leu Tyr Pro Thr His Ala Cys Arg Glu Tyr Leu 
225                 230                 235                 240 


Lys Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg Glu Asp Asn 
                245                 250                 255     


Val Pro Gln Leu Glu Asp Val Ser Met Phe Leu Lys Glu Arg Ser Gly 
            260                 265                 270         


Phe Thr Val Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp Phe Leu 
        275                 280                 285             


Ala Gly Leu Ala Tyr Arg Val Phe His Cys Thr Gln Tyr Ile Arg His 
    290                 295                 300                 


Gly Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His Glu Leu 
305                 310                 315                 320 


Leu Gly His Val Pro Leu Leu Ala Asp Pro Lys Phe Ala Gln Phe Ser 
                325                 330                 335     


Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Asp Val Gln 
            340                 345                 350         


Lys Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu Phe Gly Leu Cys Lys 
        355                 360                 365             


Gln Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly Leu Leu Ser Ser Ile 
    370                 375                 380                 


Gly Glu Leu Lys His Ala Leu Ser Asp Lys Ala Cys Val Lys Ala Phe 
385                 390                 395                 400 


Asp Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu Ile Thr Thr Phe Gln 
                405                 410                 415     


Glu Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu Ala Lys Glu Lys Met 
            420                 425                 430         


Arg Asp Phe Ala Lys Ser Ile Thr Arg Pro Phe Ser Val Tyr Phe Asn 
        435                 440                 445             


Pro Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp Thr Arg Ser Ile Glu 
    450                 455                 460                 


Asn Val Val Gln Asp Leu Arg Ser Asp Leu Asn Thr Val Cys Asp Ala 
465                 470                 475                 480 


Leu Asn Lys Met Asn Gln Tyr Leu Gly Ile 
                485                 490 


<210>  7
<211>  488
<212>  PRT
<213>  Mus musculus

<400>  7

Met Gln Pro Ala Met Met Met Phe Ser Ser Lys Tyr Trp Ala Arg Arg 
1               5                   10                  15      


Gly Leu Ser Leu Asp Ser Ala Val Pro Glu Asp His Gln Leu Leu Gly 
            20                  25                  30          


Ser Leu Thr Gln Asn Lys Ala Ile Lys Ser Glu Asp Lys Lys Ser Gly 
        35                  40                  45              


Lys Glu Pro Gly Lys Gly Asp Thr Thr Glu Ser Ser Lys Thr Ala Val 
    50                  55                  60                  


Val Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Val Lys Ala Leu Arg 
65                  70                  75                  80  


Leu Phe Gln Glu Lys His Val Asn Met Leu His Ile Glu Ser Arg Arg 
                85                  90                  95      


Ser Arg Arg Arg Ser Ser Glu Val Glu Ile Phe Val Asp Cys Glu Cys 
            100                 105                 110         


Gly Lys Thr Glu Phe Asn Glu Leu Ile Gln Leu Leu Lys Phe Gln Thr 
        115                 120                 125             


Thr Ile Val Thr Leu Asn Pro Pro Glu Ser Ile Trp Thr Glu Glu Glu 
    130                 135                 140                 


Asp Leu Glu Asp Val Pro Trp Phe Pro Arg Lys Ile Ser Glu Leu Asp 
145                 150                 155                 160 


Arg Cys Ser His Arg Val Leu Met Tyr Gly Thr Glu Leu Asp Ala Asp 
                165                 170                 175     


His Pro Gly Phe Lys Asp Asn Val Tyr Arg Gln Arg Arg Lys Tyr Phe 
            180                 185                 190         


Val Asp Val Ala Met Gly Tyr Lys Tyr Gly Gln Pro Ile Pro Arg Val 
        195                 200                 205             


Glu Tyr Thr Glu Glu Glu Thr Lys Thr Trp Gly Val Val Phe Arg Glu 
    210                 215                 220                 


Leu Ser Lys Leu Tyr Pro Thr His Ala Cys Arg Glu Tyr Leu Lys Asn 
225                 230                 235                 240 


Leu Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg Glu Asp Asn Val Pro 
                245                 250                 255     


Gln Leu Glu Asp Val Ser Met Phe Leu Lys Glu Arg Ser Gly Phe Thr 
            260                 265                 270         


Val Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp Phe Leu Ala Gly 
        275                 280                 285             


Leu Ala Tyr Arg Val Phe His Cys Thr Gln Tyr Val Arg His Gly Ser 
    290                 295                 300                 


Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His Glu Leu Leu Gly 
305                 310                 315                 320 


His Val Pro Leu Leu Ala Asp Pro Lys Phe Ala Gln Phe Ser Gln Glu 
                325                 330                 335     


Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Asp Val Gln Lys Leu 
            340                 345                 350         


Ala Thr Cys Tyr Phe Phe Thr Ile Glu Phe Gly Leu Cys Lys Gln Glu 
        355                 360                 365             


Gly Gln Leu Arg Ala Tyr Gly Ala Gly Leu Leu Ser Ser Ile Gly Glu 
    370                 375                 380                 


Leu Lys His Ala Leu Ser Asp Lys Ala Cys Val Lys Ser Phe Asp Pro 
385                 390                 395                 400 


Lys Thr Thr Cys Leu Gln Glu Cys Leu Ile Thr Thr Phe Gln Asp Ala 
                405                 410                 415     


Tyr Phe Val Ser Asp Ser Phe Glu Glu Ala Lys Glu Lys Met Arg Asp 
            420                 425                 430         


Phe Ala Lys Ser Ile Thr Arg Pro Phe Ser Val Tyr Phe Asn Pro Tyr 
        435                 440                 445             


Thr Gln Ser Ile Glu Ile Leu Lys Asp Thr Arg Ser Ile Glu Asn Val 
    450                 455                 460                 


Val Gln Asp Leu Arg Ser Asp Leu Asn Thr Val Cys Asp Ala Leu Asn 
465                 470                 475                 480 


Lys Met Asn Gln Tyr Leu Gly Ile 
                485             


<210>  8
<211>  489
<212>  PRT
<213>  Gallus gallus

<400>  8

Met Gln Pro Ala Met Met Met Phe Ser Ser Lys Tyr Trp Ala Arg Arg 
1               5                   10                  15      


Gly Phe Ser Leu Asp Ser Ala Leu Pro Glu Glu Arg Pro Gly Gly Leu 
            20                  25                  30          


Thr Ile Asn Arg Ser Ser Ser Gly Lys Asn Glu Asp Lys Lys Gly Asn 
        35                  40                  45              


Lys Gly Asn Gly Lys Gly Glu Ser Val Ser Glu Gly Gly Lys Thr Ala 
    50                  55                  60                  


Val Val Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Val Lys Ala Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Glu Lys His Val Ser Met Val His Ile Glu Ser Arg 
                85                  90                  95      


Lys Ser Lys Arg Arg Asn Ser Glu Val Glu Ile Phe Val Asp Cys Asp 
            100                 105                 110         


Cys Ser Lys Lys Glu Phe Asn Glu Leu Ile Gln Leu Leu Lys Phe Gln 
        115                 120                 125             


Thr Asn Ile Val Ser Leu Asn Pro Pro Glu Asn Ile Trp Thr Asp Glu 
    130                 135                 140                 


Glu Asp Leu Asp Cys Val Pro Trp Phe Pro Arg Lys Ile Ser Glu Leu 
145                 150                 155                 160 


Asp Lys Cys Ser Gln Arg Val Leu Met Tyr Gly Ser Glu Leu Asp Ala 
                165                 170                 175     


Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Gln Arg Arg Lys Tyr 
            180                 185                 190         


Phe Val Asp Val Ala Met Ser Tyr Lys Tyr Gly Gln Pro Ile Pro Arg 
        195                 200                 205             


Val Glu Tyr Thr Ala Glu Glu Ile Lys Thr Trp Gly Val Val Phe Arg 
    210                 215                 220                 


Glu Leu Ser Lys Leu Tyr Pro Thr His Ala Cys Arg Glu Tyr Leu Lys 
225                 230                 235                 240 


Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg Glu Asp Asn Val 
                245                 250                 255     


Pro Gln Leu Glu Asp Val Ser Ile Phe Leu Lys Glu Arg Ser Gly Phe 
            260                 265                 270         


Thr Val Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp Phe Leu Ala 
        275                 280                 285             


Gly Leu Ala Tyr Arg Val Phe His Cys Thr Gln Tyr Val Arg His Gly 
    290                 295                 300                 


Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His Glu Leu Leu 
305                 310                 315                 320 


Gly His Val Pro Leu Leu Ala Asp Pro Lys Phe Ala Gln Phe Ser Gln 
                325                 330                 335     


Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Asp Val Gln Lys 
            340                 345                 350         


Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu Phe Gly Leu Cys Lys Gln 
        355                 360                 365             


Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly Leu Leu Ser Ser Ile Gly 
    370                 375                 380                 


Glu Leu Lys His Ala Leu Ser Asp Lys Ala Lys Val Lys Thr Phe Asp 
385                 390                 395                 400 


Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu Ile Thr Thr Phe Gln Glu 
                405                 410                 415     


Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu Ala Lys Glu Lys Met Arg 
            420                 425                 430         


Asp Phe Ala Lys Ser Ile Asn Arg Pro Phe Ser Val Tyr Phe Asn Pro 
        435                 440                 445             


Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp Thr Arg Ser Ile Glu Asn 
    450                 455                 460                 


Val Val Gln Asp Leu Arg Ser Asp Leu Asn Thr Val Cys Asp Ala Leu 
465                 470                 475                 480 


Ser Lys Met Asn Arg Tyr Leu Gly Ile 
                485                 


<210>  9
<211>  444
<212>  PRT
<213>  Bos taurus

<400>  9

Met Ile Glu Asp Asn Lys Glu Asn Lys Asp His Ser Phe Glu Arg Gly 
1               5                   10                  15      


Arg Ala Thr Leu Ile Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Ile 
            20                  25                  30          


Lys Ala Leu Lys Ile Phe Gln Glu Lys His Val Asn Leu Leu His Ile 
        35                  40                  45              


Glu Ser Arg Lys Ser Lys Arg Arg Ser Ser Glu Phe Glu Ile Phe Val 
    50                  55                  60                  


Asp Cys Asp Ile Ser Arg Glu Gln Leu Asn Asp Ile Phe His Leu Leu 
65                  70                  75                  80  


Lys Ser His Ser Asn Ile Leu Ser Val Asn Leu Pro Asp Asn Phe Thr 
                85                  90                  95      


Val Lys Glu Asp Gly Met Glu Thr Val Pro Trp Phe Pro Lys Lys Ile 
            100                 105                 110         


Ser Asp Leu Asp His Cys Ala Asn Arg Val Leu Met Tyr Gly Ser Glu 
        115                 120                 125             


Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Lys Arg 
    130                 135                 140                 


Arg Lys Tyr Phe Ala Asp Leu Ala Met Asn Tyr Lys His Gly Asp Pro 
145                 150                 155                 160 


Ile Pro Arg Val Glu Phe Thr Glu Glu Glu Ile Arg Thr Trp Gly Thr 
                165                 170                 175     


Val Phe Arg Glu Leu Asn Lys Leu Tyr Pro Thr His Ala Cys Arg Glu 
            180                 185                 190         


Tyr Leu Lys Asn Leu Pro Leu Leu Ser Lys Tyr Cys Gly Tyr Arg Glu 
        195                 200                 205             


Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Asn Phe Leu Lys Glu Arg 
    210                 215                 220                 


Thr Gly Phe Ser Ile Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp 
225                 230                 235                 240 


Phe Leu Ser Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Val 
                245                 250                 255     


Arg His Ser Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His 
            260                 265                 270         


Glu Leu Leu Gly His Val Pro Leu Leu Ala Glu Pro Ser Phe Ala Gln 
        275                 280                 285             


Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Glu Glu Ala 
    290                 295                 300                 


Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Val Glu Phe Gly Leu 
305                 310                 315                 320 


Cys Lys Gln Glu Gly Gln Leu Arg Val Phe Gly Ala Gly Leu Leu Ser 
                325                 330                 335     


Ser Ile Ser Glu Leu Lys His Ala Leu Ser Gly His Ala Lys Val Lys 
            340                 345                 350         


Pro Phe Asp Pro Lys Ile Thr Cys Lys Gln Glu Cys Leu Ile Thr Thr 
        355                 360                 365             


Phe Gln Asp Val Tyr Phe Val Ser Glu Ser Phe Glu Asp Ala Lys Glu 
    370                 375                 380                 


Lys Met Arg Glu Phe Thr Lys Thr Ile Lys Arg Pro Phe Gly Val Lys 
385                 390                 395                 400 


Tyr Asn Pro Tyr Thr Arg Ser Ile Gln Ile Leu Lys Asp Thr Arg Ser 
                405                 410                 415     


Ile Thr Ser Ala Met Asn Glu Leu Gln His Glu Leu Asp Val Val Ser 
            420                 425                 430         


Asp Ala Leu Ala Lys Val Ser Arg Gln Leu Ser Ile 
        435                 440                 


<210>  10
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Glu Asp Asn Lys Glu Asn Lys Asp His Ser Leu Glu Arg Gly 
1               5                   10                  15      


Arg Ala Ser Leu Ile Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Ile 
            20                  25                  30          


Lys Ala Leu Lys Ile Phe Gln Glu Lys His Val Asn Leu Leu His Ile 
        35                  40                  45              


Glu Ser Arg Lys Ser Lys Arg Arg Asn Ser Glu Phe Glu Ile Phe Val 
    50                  55                  60                  


Asp Cys Asp Ile Asn Arg Glu Gln Leu Asn Asp Ile Phe His Leu Leu 
65                  70                  75                  80  


Lys Ser His Thr Asn Val Leu Ser Val Asn Leu Pro Asp Asn Phe Thr 
                85                  90                  95      


Leu Lys Glu Asp Gly Met Glu Thr Val Pro Trp Phe Pro Lys Lys Ile 
            100                 105                 110         


Ser Asp Leu Asp His Cys Ala Asn Arg Val Leu Met Tyr Gly Ser Glu 
        115                 120                 125             


Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Lys Arg 
    130                 135                 140                 


Arg Lys Tyr Phe Ala Asp Leu Ala Met Asn Tyr Lys His Gly Asp Pro 
145                 150                 155                 160 


Ile Pro Lys Val Glu Phe Thr Glu Glu Glu Ile Lys Thr Trp Gly Thr 
                165                 170                 175     


Val Phe Gln Glu Leu Asn Lys Leu Tyr Pro Thr His Ala Cys Arg Glu 
            180                 185                 190         


Tyr Leu Lys Asn Leu Pro Leu Leu Ser Lys Tyr Cys Gly Tyr Arg Glu 
        195                 200                 205             


Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Asn Phe Leu Lys Glu Arg 
    210                 215                 220                 


Thr Gly Phe Ser Ile Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp 
225                 230                 235                 240 


Phe Leu Ser Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Val 
                245                 250                 255     


Arg His Ser Ser Asp Pro Phe Tyr Thr Pro Glu Pro Asp Thr Cys His 
            260                 265                 270         


Glu Leu Leu Gly His Val Pro Leu Leu Ala Glu Pro Ser Phe Ala Gln 
        275                 280                 285             


Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Glu Glu Ala 
    290                 295                 300                 


Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Val Glu Phe Gly Leu 
305                 310                 315                 320 


Cys Lys Gln Asp Gly Gln Leu Arg Val Phe Gly Ala Gly Leu Leu Ser 
                325                 330                 335     


Ser Ile Ser Glu Leu Lys His Ala Leu Ser Gly His Ala Lys Val Lys 
            340                 345                 350         


Pro Phe Asp Pro Lys Ile Thr Cys Lys Gln Glu Cys Leu Ile Thr Thr 
        355                 360                 365             


Phe Gln Asp Val Tyr Phe Val Ser Glu Ser Phe Glu Asp Ala Lys Glu 
    370                 375                 380                 


Lys Met Arg Glu Phe Thr Lys Thr Ile Lys Arg Pro Phe Gly Val Lys 
385                 390                 395                 400 


Tyr Asn Pro Tyr Thr Arg Ser Ile Gln Ile Leu Lys Asp Thr Lys Ser 
                405                 410                 415     


Ile Thr Ser Ala Met Asn Glu Leu Gln His Asp Leu Asp Val Val Ser 
            420                 425                 430         


Asp Ala Leu Ala Lys Val Ser Arg Lys Pro Ser Ile 
        435                 440                 


<210>  11
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ile Glu Asp Asn Lys Glu Asn Lys Glu Asn Lys Asp His Ser Ser 
1               5                   10                  15      


Glu Arg Gly Arg Val Thr Leu Ile Phe Ser Leu Glu Asn Glu Val Gly 
            20                  25                  30          


Gly Leu Ile Lys Val Leu Lys Ile Phe Gln Glu Asn His Val Ser Leu 
        35                  40                  45              


Leu His Ile Glu Ser Arg Lys Ser Lys Gln Arg Asn Ser Glu Phe Glu 
    50                  55                  60                  


Ile Phe Val Asp Cys Asp Ile Ser Arg Glu Gln Leu Asn Asp Ile Phe 
65                  70                  75                  80  


Pro Leu Leu Lys Ser His Ala Thr Val Leu Ser Val Asp Ser Pro Asp 
                85                  90                  95      


Gln Leu Thr Ala Lys Glu Asp Val Met Glu Thr Val Pro Trp Phe Pro 
            100                 105                 110         


Lys Lys Ile Ser Asp Leu Asp Phe Cys Ala Asn Arg Val Leu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr 
    130                 135                 140                 


Arg Arg Arg Arg Lys Tyr Phe Ala Glu Leu Ala Met Asn Tyr Lys His 
145                 150                 155                 160 


Gly Asp Pro Ile Pro Lys Ile Glu Phe Thr Glu Glu Glu Ile Lys Thr 
                165                 170                 175     


Trp Gly Thr Ile Phe Arg Glu Leu Asn Lys Leu Tyr Pro Thr His Ala 
            180                 185                 190         


Cys Arg Glu Tyr Leu Arg Asn Leu Pro Leu Leu Ser Lys Tyr Cys Gly 
        195                 200                 205             


Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Asn Phe Leu 
    210                 215                 220                 


Lys Glu Arg Thr Gly Phe Ser Ile Arg Pro Val Ala Gly Tyr Leu Ser 
225                 230                 235                 240 


Pro Arg Asp Phe Leu Ser Gly Leu Ala Phe Arg Val Phe His Cys Thr 
                245                 250                 255     


Gln Tyr Val Arg His Ser Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp 
            260                 265                 270         


Thr Cys His Glu Leu Leu Gly His Val Pro Leu Leu Ala Glu Pro Ser 
        275                 280                 285             


Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser 
    290                 295                 300                 


Glu Glu Thr Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Val Glu 
305                 310                 315                 320 


Phe Gly Leu Cys Lys Gln Asp Gly Gln Leu Arg Val Phe Gly Ala Gly 
                325                 330                 335     


Leu Leu Ser Ser Ile Ser Glu Leu Lys His Ala Leu Ser Gly His Ala 
            340                 345                 350         


Lys Val Lys Pro Phe Asp Pro Lys Ile Ala Cys Lys Gln Glu Cys Leu 
        355                 360                 365             


Ile Thr Ser Phe Gln Asp Val Tyr Phe Val Ser Glu Ser Phe Glu Asp 
    370                 375                 380                 


Ala Lys Glu Lys Met Arg Glu Phe Ala Lys Thr Val Lys Arg Pro Phe 
385                 390                 395                 400 


Gly Leu Lys Tyr Asn Pro Tyr Thr Gln Ser Val Gln Val Leu Arg Asp 
                405                 410                 415     


Thr Lys Ser Ile Thr Ser Ala Met Asn Glu Leu Arg Tyr Asp Leu Asp 
            420                 425                 430         


Val Ile Ser Asp Ala Leu Ala Arg Val Thr Arg Trp Pro Ser Val 
        435                 440                 445         


<210>  12
<211>  445
<212>  PRT
<213>  Gallus gallus

<400>  12

Met Ile Glu Asp Asn Lys Glu Asn Lys Asp His Ala Pro Glu Arg Gly 
1               5                   10                  15      


Arg Thr Ala Ile Ile Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Val 
            20                  25                  30          


Lys Ala Leu Lys Leu Phe Gln Glu Lys His Val Asn Leu Val His Ile 
        35                  40                  45              


Glu Ser Arg Lys Ser Lys Arg Arg Asn Ser Glu Phe Glu Ile Phe Val 
    50                  55                  60                  


Asp Cys Asp Ser Asn Arg Glu Gln Leu Asn Glu Ile Phe Gln Leu Leu 
65                  70                  75                  80  


Lys Ser His Val Ser Ile Val Ser Met Asn Pro Thr Glu His Phe Asn 
                85                  90                  95      


Val Gln Glu Asp Gly Asp Met Glu Asn Ile Pro Trp Tyr Pro Lys Lys 
            100                 105                 110         


Ile Ser Asp Leu Asp Lys Cys Ala Asn Arg Val Leu Met Tyr Gly Ser 
        115                 120                 125             


Asp Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Lys 
    130                 135                 140                 


Arg Arg Lys Tyr Phe Ala Asp Leu Ala Met Asn Tyr Lys His Gly Asp 
145                 150                 155                 160 


Pro Ile Pro Glu Ile Glu Phe Thr Glu Glu Glu Ile Lys Thr Trp Gly 
                165                 170                 175     


Thr Val Tyr Arg Glu Leu Asn Lys Leu Tyr Pro Thr His Ala Cys Arg 
            180                 185                 190         


Glu Tyr Leu Lys Asn Leu Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg 
        195                 200                 205             


Glu Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Arg Phe Leu Lys Glu 
    210                 215                 220                 


Arg Thr Gly Phe Thr Ile Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg 
225                 230                 235                 240 


Asp Phe Leu Ala Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr 
                245                 250                 255     


Val Arg His Ser Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys 
            260                 265                 270         


His Glu Leu Leu Gly His Val Pro Leu Leu Ala Glu Pro Ser Phe Ala 
        275                 280                 285             


Gln Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu 
    290                 295                 300                 


Ala Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Val Glu Phe Gly 
305                 310                 315                 320 


Leu Cys Lys Gln Glu Gly Gln Leu Arg Val Tyr Gly Ala Gly Leu Leu 
                325                 330                 335     


Ser Ser Ile Ser Glu Leu Lys His Ser Leu Ser Gly Ser Ala Lys Val 
            340                 345                 350         


Lys Pro Phe Asp Pro Lys Val Thr Cys Lys Gln Glu Cys Leu Ile Thr 
        355                 360                 365             


Thr Phe Gln Glu Val Tyr Phe Val Ser Glu Ser Phe Glu Glu Ala Lys 
    370                 375                 380                 


Glu Lys Met Arg Glu Phe Ala Lys Thr Ile Lys Arg Pro Phe Gly Val 
385                 390                 395                 400 


Lys Tyr Asn Pro Tyr Thr Gln Ser Val Gln Ile Leu Lys Asp Thr Lys 
                405                 410                 415     


Ser Ile Ala Ser Val Val Asn Glu Leu Arg His Glu Leu Asp Ile Val 
            420                 425                 430         


Ser Asp Ala Leu Ser Lys Met Gly Lys Gln Leu Glu Val 
        435                 440                 445 


<210>  13
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 
            20                  25                  30          


Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys 
    450         


<210>  14
<211>  466
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  14

Met Ser Ala Val Val Leu Glu Asn Gly Gly Leu Ser Arg Lys Phe Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Ser Asn Glu Asn 
            20                  25                  30          


Ser Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Ile Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr Tyr Leu Asp Lys Arg Ser Met Pro Ala Leu Glu Asp Ile Ile Gln 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Thr Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe Arg Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Phe Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Gly Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Glu Tyr Pro Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Met Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Ile Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Val Gly Ile Leu Cys Asn Ala Leu 
        435                 440                 445             


Gln Lys Asn Lys Ser Glu Ala Ile Tyr Arg Ile Gly Leu Ser Thr Asp 
    450                 455                 460                 


His Cys 
465     


<210>  15
<211>  453
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Ala Val Val Leu Glu Asn Gly Val Leu Ser Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Ser Asn Gln Asn 
            20                  25                  30          


Gly Ala Val Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Glu Ile Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Asn Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr Tyr Leu Asp Lys Arg Ser Lys Pro Val Leu Gly Ser Ile Ile Lys 
                85                  90                  95      


Ser Leu Arg Asn Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Glu Lys Asn Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Thr Glu Glu Glu Arg Lys Thr Trp Gly Thr Val Phe Arg 
            180                 185                 190         


Thr Leu Lys Ala Leu Tyr Lys Thr His Ala Cys Tyr Glu His Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe Arg Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Glu 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Asp Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Cys Gln Glu Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Thr Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Val Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Val Gly Ile Leu Cys His Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys Ser 
    450             


<210>  16
<211>  451
<212>  PRT
<213>  Bos taurus

<400>  16

Met Ser Ala Leu Val Leu Glu Ser Arg Ala Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Gly Asn Ser Asp Gln Asn 
            20                  25                  30          


Ala Val Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu Ala 
        35                  40                  45              


Arg Val Leu Arg Leu Phe Glu Glu Asn Asp Ile Asn Leu Thr His Ile 
    50                  55                  60                  


Glu Ser Arg Pro Ser Arg Leu Arg Lys Asp Glu Tyr Glu Phe Phe Thr 
65                  70                  75                  80  


Asn Leu Asp Gln Arg Ser Val Pro Ala Leu Ala Asn Ile Ile Lys Ile 
                85                  90                  95      


Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp Lys 
            100                 105                 110         


Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu Asp 
        115                 120                 125             


Asn Phe Ala Asn Gln Val Leu Ser Tyr Gly Ala Glu Leu Asp Ala Asp 
    130                 135                 140                 


His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln Phe 
145                 150                 155                 160 


Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg Val 
                165                 170                 175     


Glu Tyr Thr Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Arg Thr 
            180                 185                 190         


Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu His Asn His Ile 
        195                 200                 205             


Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe Arg Glu Asp Asn Ile Pro 
    210                 215                 220                 


Gln Leu Glu Glu Val Ser Gln Phe Leu Gln Ser Cys Thr Gly Phe Arg 
225                 230                 235                 240 


Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly Gly 
                245                 250                 255     


Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly Ser 
            260                 265                 270         


Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu Gly 
        275                 280                 285             


His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln Glu 
    290                 295                 300                 


Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys Leu 
305                 310                 315                 320 


Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Gly 
                325                 330                 335     


Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly Glu 
            340                 345                 350         


Leu Gln Tyr Cys Leu Ser Asp Lys Pro Lys Leu Leu Pro Leu Glu Leu 
        355                 360                 365             


Glu Lys Thr Ala Val Gln Glu Tyr Thr Ile Thr Glu Phe Gln Pro Leu 
    370                 375                 380                 


Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg Asn 
385                 390                 395                 400 


Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val His Tyr Asp Pro Tyr 
                405                 410                 415     


Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile Leu 
            420                 425                 430         


Ala Asp Ser Ile Ser Ser Glu Val Glu Ile Leu Cys Ser Ala Leu Gln 
        435                 440                 445             


Lys Leu Lys 
    450     


<210>  17
<211>  446
<212>  PRT
<213>  Gallus gallus

<400>  17

Met Asp Ala Gln His Cys Lys Met Asn Gly Asp Ser Phe Gln Glu Ser 
1               5                   10                  15      


Thr Tyr Thr Glu Glu Pro Ser Asn Lys Asn Gly Val Ile Ser Leu Ile 
            20                  25                  30          


Phe Ser Leu Lys Glu Glu Val Gly Ala Leu Ala Lys Val Leu Arg Thr 
        35                  40                  45              


Phe Glu Glu Lys Gly Ile Asn Leu Thr His Ile Glu Ser Arg Pro Ser 
    50                  55                  60                  


Arg Leu Asn Lys Asp Glu Tyr Glu Phe Phe Ile Asn Leu Glu Gly Lys 
65                  70                  75                  80  


Asn Val Pro Ala Leu Asp Lys Ile Ile Lys Ser Leu Arg Asn Asp Ile 
                85                  90                  95      


Gly Val Thr Val His Glu Leu Ser Arg Thr Lys Lys Lys Asp Thr Val 
            100                 105                 110         


Pro Trp Phe Pro Arg Ser Ile Gln Glu Leu Asp Arg Phe Ala Asn Gln 
        115                 120                 125             


Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala Asp His Pro Gly Phe Lys 
    130                 135                 140                 


Asp Pro Val Tyr Arg Ala Arg Arg Lys Glu Phe Ala Asp Ile Ala Tyr 
145                 150                 155                 160 


Asn Tyr Arg His Gly Gln Pro Ile Pro Arg Val Thr Tyr Thr Glu Glu 
                165                 170                 175     


Glu Lys Lys Thr Trp Gly Thr Val Phe Arg Glu Leu Lys Asn Leu Tyr 
            180                 185                 190         


Pro Thr His Ala Cys Tyr Glu His Asn His Val Phe Pro Leu Leu Glu 
        195                 200                 205             


Lys Tyr Cys Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu Asp Val 
    210                 215                 220                 


Ser Lys Phe Leu Gln Thr Cys Thr Gly Phe Arg Leu Arg Pro Val Ala 
225                 230                 235                 240 


Gly Leu Leu Ser Ser Arg Asp Phe Leu Ala Gly Leu Ala Phe Arg Val 
                245                 250                 255     


Phe His Ser Thr Gln Tyr Ile Arg His Ala Ser Lys Pro Met Tyr Thr 
            260                 265                 270         


Pro Glu Pro Asp Ile Cys His Glu Leu Leu Gly His Val Pro Leu Phe 
        275                 280                 285             


Ala Asp Pro Ser Phe Ala Gln Phe Ser Gln Glu Ile Gly Leu Ala Ser 
    290                 295                 300                 


Leu Gly Ala Pro Asp Asp Phe Ile Glu Lys Leu Ala Thr Val Tyr Trp 
305                 310                 315                 320 


Phe Thr Val Glu Phe Gly Leu Cys Lys Glu Gly Asp Ser Leu Lys Ala 
                325                 330                 335     


Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly Glu Leu Gln Tyr Cys Leu 
            340                 345                 350         


Ser Gly Lys Pro Glu Ile Arg Pro Leu Val Leu Glu Asn Thr Ser Val 
        355                 360                 365             


Gln Lys Tyr Ser Val Thr Glu Phe Gln Pro Thr Tyr Phe Val Ala Glu 
    370                 375                 380                 


Ser Phe Asn Asp Ala Lys Glu Lys Leu Arg Lys Phe Ala Gln Thr Ile 
385                 390                 395                 400 


Pro Arg Pro Phe Ser Val Arg Tyr Asn Pro Tyr Thr Gln Arg Ile Glu 
                405                 410                 415     


Val Leu Asp Asn Ala Lys Gln Leu Lys Asn Leu Ala Asp Thr Ile Asn 
            420                 425                 430         


Ser Glu Met Gly Ile Leu Cys Asn Ala Leu Gln Lys Ile Lys 
        435                 440                 445     


