                               SEQUENCE LISTING

<110> CERENIS THERAPEUTICS HOLDING S.A.

<120> HDL THERAPY MARKERS

<130> CRN-016WO

<140>
<141>

<150> 61/988,095
<151> 2014-05-02

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210> 2
<211> 6786
<212> DNA
<213> Homo sapiens

<400> 2
atggcttgtt ggcctcagct gaggttgctg ctgtggaaga acctcacttt cagaagaaga       60

caaacatgtc agctgctgct ggaagtggcc tggcctctat ttatcttcct gatcctgatc      120

tctgttcggc tgagctaccc accctatgaa caacatgaat gccattttcc aaataaagcc      180

atgccctctg caggaacact tccttgggtt caggggatta tctgtaatgc caacaacccc      240

tgtttccgtt acccgactcc tggggaggct cccggagttg ttggaaactt taacaaatcc      300

attgtggctc gcctgttctc agatgctcgg aggcttcttt tatacagcca gaaagacacc      360

agcatgaagg acatgcgcaa agttctgaga acattacagc agatcaagaa atccagctca      420

aacttgaagc ttcaagattt cctggtggac aatgaaacct tctctgggtt cctgtatcac      480

aacctctctc tcccaaagtc tactgtggac aagatgctga gggctgatgt cattctccac      540

aaggtatttt tgcaaggcta ccagttacat ttgacaagtc tgtgcaatgg atcaaaatca      600

gaagagatga ttcaacttgg tgaccaagaa gtttctgagc tttgtggcct accaagggag      660

aaactggctg cagcagagcg agtacttcgt tccaacatgg acatcctgaa gccaatcctg      720

agaacactaa actctacatc tcccttcccg agcaaggagc tggctgaagc cacaaaaaca      780

ttgctgcata gtcttgggac tctggcccag gagctgttca gcatgagaag ctggagtgac      840

atgcgacagg aggtgatgtt tctgaccaat gtgaacagct ccagctcctc cacccaaatc      900

taccaggctg tgtctcgtat tgtctgcggg catcccgagg gaggggggct gaagatcaag      960

tctctcaact ggtatgagga caacaactac aaagccctct ttggaggcaa tggcactgag     1020

gaagatgctg aaaccttcta tgacaactct acaactcctt actgcaatga tttgatgaag     1080

aatttggagt ctagtcctct ttcccgcatt atctggaaag ctctgaagcc gctgctcgtt     1140

gggaagatcc tgtatacacc tgacactcca gccacaaggc aggtcatggc tgaggtgaac     1200

aagaccttcc aggaactggc tgtgttccat gatctggaag gcatgtggga ggaactcagc     1260

cccaagatct ggaccttcat ggagaacagc caagaaatgg accttgtccg gatgctgttg     1320

gacagcaggg acaatgacca cttttgggaa cagcagttgg atggcttaga ttggacagcc     1380

caagacatcg tggcgttttt ggccaagcac ccagaggatg tccagtccag taatggttct     1440

gtgtacacct ggagagaagc tttcaacgag actaaccagg caatccggac catatctcgc     1500

ttcatggagt gtgtcaacct gaacaagcta gaacccatag caacagaagt ctggctcatc     1560

aacaagtcca tggagctgct ggatgagagg aagttctggg ctggtattgt gttcactgga     1620

attactccag gcagcattga gctgccccat catgtcaagt acaagatccg aatggacatt     1680

gacaatgtgg agaggacaaa taaaatcaag gatgggtact gggaccctgg tcctcgagct     1740

gacccctttg aggacatgcg gtacgtctgg gggggcttcg cctacttgca ggatgtggtg     1800

gagcaggcaa tcatcagggt gctgacgggc accgagaaga aaactggtgt ctatatgcaa     1860

cagatgccct atccctgtta cgttgatgac atctttctgc gggtgatgag ccggtcaatg     1920

cccctcttca tgacgctggc ctggatttac tcagtggctg tgatcatcaa gggcatcgtg     1980

tatgagaagg aggcacggct gaaagagacc atgcggatca tgggcctgga caacagcatc     2040

ctctggttta gctggttcat tagtagcctc attcctcttc ttgtgagcgc tggcctgcta     2100

gtggtcatcc tgaagttagg aaacctgctg ccctacagtg atcccagcgt ggtgtttgtc     2160

ttcctgtccg tgtttgctgt ggtgacaatc ctgcagtgct tcctgattag cacactcttc     2220

tccagagcca acctggcagc agcctgtggg ggcatcatct acttcacgct gtacctgccc     2280

tacgtcctgt gtgtggcatg gcaggactac gtgggcttca cactcaagat cttcgctagc     2340

ctgctgtctc ctgtggcttt tgggtttggc tgtgagtact ttgccctttt tgaggagcag     2400

ggcattggag tgcagtggga caacctgttt gagagtcctg tggaggaaga tggcttcaat     2460

ctcaccactt cggtctccat gatgctgttt gacaccttcc tctatggggt gatgacctgg     2520

tacattgagg ctgtctttcc aggccagtac ggaattccca ggccctggta ttttccttgc     2580

accaagtcct actggtttgg cgaggaaagt gatgagaaga gccaccctgg ttccaaccag     2640

aagagaatat cagaaatctg catggaggag gaacccaccc acttgaagct gggcgtgtcc     2700

attcagaacc tggtaaaagt ctaccgagat gggatgaagg tggctgtcga tggcctggca     2760

ctgaattttt atgagggcca gatcacctcc ttcctgggcc acaatggagc ggggaagacg     2820

accaccatgt caatcctgac cgggttgttc cccccgacct cgggcaccgc ctacatcctg     2880

ggaaaagaca ttcgctctga gatgagcacc atccggcaga acctgggggt ctgtccccag     2940

cataacgtgc tgtttgacat gctgactgtc gaagaacaca tctggttcta tgcccgcttg     3000

aaagggctct ctgagaagca cgtgaaggcg gagatggagc agatggccct ggatgttggt     3060

ttgccatcaa gcaagctgaa aagcaaaaca agccagctgt caggtggaat gcagagaaag     3120

ctatctgtgg ccttggcctt tgtcggggga tctaaggttg tcattctgga tgaacccaca     3180

gctggtgtgg acccttactc ccgcagggga atatgggagc tgctgctgaa ataccgacaa     3240

ggccgcacca ttattctctc tacacaccac atggatgaag cggacgtcct gggggacagg     3300

attgccatca tctcccatgg gaagctgtgc tgtgtgggct cctccctgtt tctgaagaac     3360

cagctgggaa caggctacta cctgaccttg gtcaagaaag atgtggaatc ctccctcagt     3420

tcctgcagaa acagtagtag cactgtgtca tacctgaaaa aggaggacag tgtttctcag     3480

agcagttctg atgctggcct gggcagcgac catgagagtg acacgctgac catcgatgtc     3540

tctgctatct ccaacctcat caggaagcat gtgtctgaag cccggctggt ggaagacata     3600

gggcatgagc tgacctatgt gctgccatat gaagctgcta aggagggagc ctttgtggaa     3660

ctctttcatg agattgatga ccggctctca gacctgggca tttctagtta tggcatctca     3720

gagacgaccc tggaagaaat attcctcaag gtggccgaag agagtggggt ggatgctgag     3780

acctcagatg gtaccttgcc agcaagacga aacaggcggg ccttcgggga caagcagagc     3840

tgtcttcgcc cgttcactga agatgatgct gctgatccaa atgattctga catagaccca     3900

gaatccagag agacagactt gctcagtggg atggatggca aagggtccta ccaggtgaaa     3960

ggctggaaac ttacacagca acagtttgtg gcccttttgt ggaagagact gctaattgcc     4020

agacggagtc ggaaaggatt ttttgctcag attgtcttgc cagctgtgtt tgtctgcatt     4080

gcccttgtgt tcagcctgat cgtgccaccc tttggcaagt accccagcct ggaacttcag     4140

ccctggatgt acaacgaaca gtacacattt gtcagcaatg atgctcctga ggacacggga     4200

accctggaac tcttaaacgc cctcaccaaa gaccctggct tcgggacccg ctgtatggaa     4260

ggaaacccaa tcccagacac gccctgccag gcaggggagg aagagtggac cactgcccca     4320

gttccccaga ccatcatgga cctcttccag aatgggaact ggacaatgca gaacccttca     4380

cctgcatgcc agtgtagcag cgacaaaatc aagaagatgc tgcctgtgtg tcccccaggg     4440

gcaggggggc tgcctcctcc acaaagaaaa caaaacactg cagatatcct tcaggacctg     4500

acaggaagaa acatttcgga ttatctggtg aagacgtatg tgcagatcat agccaaaagc     4560

ttaaagaaca agatctgggt gaatgagttt aggtatggcg gcttttccct gggtgtcagt     4620

aatactcaag cacttcctcc gagtcaagaa gttaatgatg ccatcaaaca aatgaagaaa     4680

cacctaaagc tggccaagga cagttctgca gatcgatttc tcaacagctt gggaagattt     4740

atgacaggac tggacaccaa aaataatgtc aaggtgtggt tcaataacaa gggctggcat     4800

gcaatcagct ctttcctgaa tgtcatcaac aatgccattc tccgggccaa cctgcaaaag     4860

ggagagaacc ctagccatta tggaattact gctttcaatc atcccctgaa tctcaccaag     4920

cagcagctct cagaggtggc tctgatgacc acatcagtgg atgtccttgt gtccatctgt     4980

gtcatctttg caatgtcctt cgtcccagcc agctttgtcg tattcctgat ccaggagcgg     5040

gtcagcaaag caaaacacct gcagttcatc agtggagtga agcctgtcat ctactggctc     5100

tctaattttg tctgggatat gtgcaattac gttgtccctg ccacactggt cattatcatc     5160

ttcatctgct tccagcagaa gtcctatgtg tcctccacca atctgcctgt gctagccctt     5220

ctacttttgc tgtatgggtg gtcaatcaca cctctcatgt acccagcctc ctttgtgttc     5280

aagatcccca gcacagccta tgtggtgctc accagcgtga acctcttcat tggcattaat     5340

ggcagcgtgg ccacctttgt gctggagctg ttcaccgaca ataagctgaa taatatcaat     5400

gatatcctga agtccgtgtt cttgatcttc ccacattttt gcctgggacg agggctcatc     5460

gacatggtga aaaaccaggc aatggctgat gccctggaaa ggtttgggga gaatcgcttt     5520

gtgtcaccat tatcttggga cttggtggga cgaaacctct tcgccatggc cgtggaaggg     5580

gtggtgttct tcctcattac tgttctgatc cagtacagat tcttcatcag gcccagacct     5640

gtaaatgcaa agctatctcc tctgaatgat gaagatgaag atgtgaggcg ggaaagacag     5700

agaattcttg atggtggagg ccagaatgac atcttagaaa tcaaggagtt gacgaagata     5760

tatagaagga agcggaagcc tgctgttgac aggatttgcg tgggcattcc tcctggtgag     5820

tgctttgggc tcctgggagt taatggggct ggaaaatcat caactttcaa gatgttaaca     5880

ggagatacca ctgttaccag aggagatgct ttccttaaca aaaatagtat cttatcaaac     5940

atccatgaag tacatcagaa catgggctac tgccctcagt ttgatgccat cacagagctg     6000

ttgactggga gagaacacgt ggagttcttt gcccttttga gaggagtccc agagaaagaa     6060

gttggcaagg ttggtgagtg ggcgattcgg aaactgggcc tcgtgaagta tggagaaaaa     6120

tatgctggta actatagtgg aggcaacaaa cgcaagctct ctacagccat ggctttgatc     6180

ggcgggcctc ctgtggtgtt tctggatgaa cccaccacag gcatggatcc caaagcccgg     6240

cggttcttgt ggaattgtgc cctaagtgtt gtcaaggagg ggagatcagt agtgcttaca     6300

tctcatagta tggaagagtg tgaagctctt tgcactagga tggcaatcat ggtcaatgga     6360

aggttcaggt gccttggcag tgtccagcat ctaaaaaata ggtttggaga tggttataca     6420

atagttgtac gaatagcagg gtccaacccg gacctgaagc ctgtccagga tttctttgga     6480

cttgcatttc ctggaagtgt tctaaaagag aaacaccgga acatgctaca ataccagctt     6540

ccatcttcat tatcttctct ggccaggata ttcagcatcc tctcccagag caaaaagcga     6600

ctccacatag aagactactc tgtttctcag acaacacttg accaagtatt tgtgaacttt     6660

gccaaggacc aaagtgatga tgaccactta aaagacctct cattacacaa aaaccagaca     6720

gtagtggacg ttgcagttct cacatctttt ctacaggatg agaaagtgaa agaaagctat     6780

gtatga                                                                6786


<210> 3
<211> 2261
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (780)..(780)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1555)..(1555)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1648)..(1648)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (1974)..(1974)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2168)..(2168)
<223> Any amino acid

<400> 3
Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Xaa Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Xaa  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Arg Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Xaa Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Xaa Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Xaa Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210> 4
<211> 2946
<212> DNA
<213> Homo sapiens

<400> 4
gctttataaa ggggagtttc cctgcacaag ctctctctct tgtctgccgc catgtgagac       60

atgcctttca ccttccgcca tgatcatgag gcttccccag ccacatggaa ctaatgccag      120

cagttactct gcagagatga cggagcccaa gtcggtgtgt gtctcggtgg atgaggtggt      180

gtccagcaac atggaggcca ctgagacgga cctgctgaat ggacatctga aaaaagtaga      240

taataacctc acggaagccc agcgcttctc ctccttgcct cggagggcag ctgtgaacat      300

tgaattcagg gacctttcct attcggttcc tgaaggaccc tggtggagga agaaaggata      360

caagaccctc ctgaaaggaa tttccgggaa gttcaatagt ggtgagttgg tggccattat      420

gggtccttcc ggggccggga agtccacgct gatgaacatc ctggctggat acagggagac      480

gggcatgaag ggggccgtcc tcatcaacgg cctgccccgg gacctgcgct gcttccggaa      540

ggtgtcctgc tacatcatgc aggatgacat gctgctgccg catctcactg tgcaggaggc      600

catgatggtg tcggcacatc tgaagcttca ggagaaggat gaaggcagaa gggaaatggt      660

caaggagata ctgacagcgc tgggcttgct gtcttgcgcc aacacgcgga ccgggagcct      720

gtcaggtggt cagcgcaagc gcctggccat cgcgctggag ctggtgaaca accctccagt      780

catgttcttc gatgagccca ccagcggcct ggacagcgcc tcctgcttcc aggtggtctc      840

gctgatgaaa gggctcgctc aagggggtcg ctccatcatt tgcaccatcc accagcccag      900

cgccaaactc ttcgagctgt tcgaccagct ttacgtcctg agtcaaggac aatgtgtgta      960

ccggggaaaa gtctgcaatc ttgtgccata tttgagggat ttgggtctga actgcccaac     1020

ctaccacaac ccagcagatt ttgtcatgga ggttgcatcc ggcgagtacg gtgatcagaa     1080

cagtcggctg gtgagagcgg ttcgggaggg catgtgtgac tcagaccaca agagagacct     1140

cgggggtgat gccgaggtga acccttttct ttggcaccgg ccctctgaag aggactcctc     1200

gtccatggaa ggctgccaca gcttctctgc cagctgcctc acgcagttct gcatcctctt     1260

caagaggacc ttcctcagca tcatgaggga ctcggtcctg acacacctgc gcatcacctc     1320

gcacattggg atcggcctcc tcattggcct gctgtacttg gggatcggga acgaagccaa     1380

gaaggtcttg agcaactccg gcttcctctt cttctccatg ctgttcctca tgttcgcggc     1440

cctcatgcct actgttctga catttcccct ggagatggga gtctttcttc gggaacacct     1500

gaactactgg tacagcctga aggcctacta cctggccaag accatggcag acgtgccctt     1560

tcagatcatg ttcccagtgg cctactgcag catcgtgtac tggatgacgt cgcagccgtc     1620

cgacgccgtg cgctttgtgc tgtttgccgc gctgggcacc atgacctccc tggtggcaca     1680

gtccctgggc ctgctgatcg gagccgcctc cacgtccctg caggtggcca ctttcgtggg     1740

cccagtgaca gccatcccgg tgctcctgtt ctcggggttc ttcgtcagct tcgacaccat     1800

ccccacgtac ctacagtgga tgtcctacat ctcctatgtc aggtatgggt tcgaaggggt     1860

catcctctcc atctatggct tagaccggga agatctgcac tgtgacatcg acgagacgtg     1920

ccacttccag aagtcggagg ccatcctgcg ggagctggac gtggaaaatg ccaagctgta     1980

cctggacttc atcgtactcg ggattttctt catctccctc cgcctcattg cctattttgt     2040

cctcaggtac aaaatccggg cagagaggta aaacacctga atgccaggaa acaggaagat     2100

tagacactgt ggccgagggc acgtctagaa tcgaggaggc aagcctgtgc ccgaccgacg     2160

acacagagac tcttctgatc caacccctag aaccgcgttg ggtttgtggg tgtctcgtgc     2220

tcagccactc tgcccagctg ggttggatct tctctccatt cccctttcta gctttaacta     2280

ggaagatgta ggcagattgg tggttttttt ttttttaaca tacagaattt taaataccac     2340

aactggggca gaatttaaag ctgcaacaca gctggtgatg agaggcttcc tcagtccagt     2400

cgctccttag caccaggcac cgtgggtcct ggatggggaa ctgcaagcag cctctcagct     2460

gatggctgca cagtcagatg tctggtggca gagagtccga gcatggagcg attccatttt     2520

atgactgttg tttttcacat tttcatcttt ctaaggtgtg tctcttttcc aatgagaagt     2580

catttttgca agccaaaagt cgatcaatcg cattcatttt aagaaattat acctttttag     2640

tacttgctga agaatgattc agggtaaatc acatactttg tttagagagg cgaggggttt     2700

aaccgagtca cccagctggt ctcatacata gacagcactt gtgaaggatt gaatgcaggt     2760

tccaggtgga gggaagacgt ggacaccatc tccactgagc catgcagaca tttttaaaag     2820

ctatacaaaa aattgtgaga agacattggc caactctttc aaagtctttc tttttccacg     2880

tgcttcttat tttaagcgaa atatattgtt tgtttcttcc taaaaaaaaa aaaaaaaaaa     2940

aaaaaa                                                                2946


<210> 5
<211> 678
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 
            180                 185                 190         


Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 
        195                 200                 205             


Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 
    210                 215                 220                 


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
225                 230                 235                 240 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
                245                 250                 255     


Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 
            260                 265                 270         


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 
        275                 280                 285             


Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 
    290                 295                 300                 


Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 
305                 310                 315                 320 


Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 
                325                 330                 335     


Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 
            340                 345                 350         


His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 
        355                 360                 365             


His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys Gly Leu 
    370                 375                 380                 


Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser 
385                 390                 395                 400 


Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile 
                405                 410                 415     


Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile Gly 
            420                 425                 430         


Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala 
        435                 440                 445             


Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe 
    450                 455                 460                 


Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu 
465                 470                 475                 480 


Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys 
                485                 490                 495     


Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile Met 
            500                 505                 510         


Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln Pro 
        515                 520                 525             


Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr 
    530                 535                 540                 


Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser Thr 
545                 550                 555                 560 


Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val 
                565                 570                 575     


Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr 
            580                 585                 590         


Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly 
        595                 600                 605             


Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp 
    610                 615                 620                 


Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg Glu 
625                 630                 635                 640 


Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu Gly 
                645                 650                 655     


Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg Tyr 
            660                 665                 670         


Lys Ile Arg Ala Glu Arg 
        675             


<210> 6
<211> 4262
<212> DNA
<213> Homo sapiens

<400> 6
agtttccgag gaacttttcg ccggcgccgg gccgcctctg aggccagggc aggacacgaa       60

cgcgcggagc ggcggcggcg actgagagcc ggggccgcgg cggcgctccc taggaagggc      120

cgtacgaggc ggcgggcccg gcgggcctcc cggaggaggc ggctgcgcca tggacgagcc      180

acccttcagc gaggcggctt tggagcaggc gctgggcgag ccgtgcgatc tggacgcggc      240

gctgctgacc gacatcgaag gtgaagtcgg cgcggggagg ggtagggcca acggcctgga      300

cgccccaagg gcgggcgcag atcgcggagc catggattgc actttcgaag acatgcttca      360

gcttatcaac aaccaagaca gtgacttccc tggcctattt gacccaccct atgctgggag      420

tggggcaggg ggcacagacc ctgccagccc cgataccagc tccccaggca gcttgtctcc      480

acctcctgcc acattgagct cctctcttga agccttcctg agcgggccgc aggcagcgcc      540

ctcacccctg tcccctcccc agcctgcacc cactccattg aagatgtacc cgtccatgcc      600

cgctttctcc cctgggcctg gtatcaagga agagtcagtg ccactgagca tcctgcagac      660

ccccacccca cagcccctgc caggggccct cctgccacag agcttcccag ccccagcccc      720

accgcagttc agctccaccc ctgtgttagg ctaccccagc cctccgggag gcttctctac      780

aggaagccct cccgggaaca cccagcagcc gctgcctggc ctgccactgg cttccccgcc      840

aggggtcccg cccgtctcct tgcacaccca ggtccagagt gtggtccccc agcagctact      900

gacagtcaca gctgccccca cggcagcccc tgtaacgacc actgtgacct cgcagatcca      960

gcaggtcccg gtcctgctgc agccccactt catcaaggca gactcgctgc ttctgacagc     1020

catgaagaca gacggagcca ctgtgaaggc ggcaggtctc agtcccctgg tctctggcac     1080

cactgtgcag acagggcctt tgccgaccct ggtgagtggc ggaaccatct tggcaacagt     1140

cccactggtc gtagatgcgg agaagctgcc tatcagccgg ctcgcagctg gcagcaaggc     1200

cccggcctct gcccagagcc gtggagagaa gcgcacagcc cacaacgcca ttgagaagcg     1260

ctaccgctcc tccatcaatg acaaaatcat tgagctcaag gatctggtgg tgggcactga     1320

ggcaaagctg aataaatctg ctgtcttgcg caaggccatc gactacattc gctttctgca     1380

acacagcaac cagaaactca agcaggagaa cctaagtctg cgcactgctg tccacaaaag     1440

caaatctctg aaggatctgg tgtcggcctg tggcagtgga gggaacacag acgtgctcat     1500

ggagggcgtg aagactgagg tggaggacac actgacccca cccccctcgg atgctggctc     1560

acctttccag agcagcccct tgtcccttgg cagcaggggc agtggcagcg gtggcagtgg     1620

cagtgactcg gagcctgaca gcccagtctt tgaggacagc aaggcaaagc cagagcagcg     1680

gccgtctctg cacagccggg gcatgctgga ccgctcccgc ctggccctgt gcacgctcgt     1740

cttcctctgc ctgtcctgca accccttggc ctccttgctg ggggcccggg ggcttcccag     1800

cccctcagat accaccagcg tctaccatag ccctgggcgc aacgtgctgg gcaccgagag     1860

cagagatggc cctggctggg cccagtggct gctgccccca gtggtctggc tgctcaatgg     1920

gctgttggtg ctcgtctcct tggtgcttct ctttgtctac ggtgagccag tcacacggcc     1980

ccactcaggc cccgccgtgt acttctggag gcatcgcaag caggctgacc tggacctggc     2040

ccggggagac tttgcccagg ctgcccagca gctgtggctg gccctgcggg cactgggccg     2100

gcccctgccc acctcccacc tggacctggc ttgtagcctc ctctggaacc tcatccgtca     2160

cctgctgcag cgtctctggg tgggccgctg gctggcaggc cgggcagggg gcctgcagca     2220

ggactgtgct ctgcgagtgg atgctagcgc cagcgcccga gacgcagccc tggtctacca     2280

taagctgcac cagctgcaca ccatggggaa gcacacaggc gggcacctca ctgccaccaa     2340

cctggcgctg agtgccctga acctggcaga gtgtgcaggg gatgccgtgt ctgtggcgac     2400

gctggccgag atctatgtgg cggctgcatt gagagtgaag accagtctcc cacgggcctt     2460

gcattttctg acacgcttct tcctgagcag tgcccgccag gcctgcctgg cacagagtgg     2520

ctcagtgcct cctgccatgc agtggctctg ccaccccgtg ggccaccgtt tcttcgtgga     2580

tggggactgg tccgtgctca gtaccccatg ggagagcctg tacagcttgg ccgggaaccc     2640

agtggacccc ctggcccagg tgactcagct attccgggaa catctcttag agcgagcact     2700

gaactgtgtg acccagccca accccagccc tgggtcagct gatggggaca aggaattctt     2760

ggatgccctc gggtacctgc agctgctgaa cagctgttct gatgctgcgg gggctcctgc     2820

ctacagcttc tccatcagtt ccagcatggc caccaccacc ggcgtagacc cggtggccaa     2880

gtggtgggcc tctctgacag ctgtggtgat ccactggctg cggcgggatg aggaggcggc     2940

tgagcggctg tgcccgctgg tggagcacct gccccgggtg ctgcaggagt ctgagagacc     3000

cctgcccagg gcagctctgc actccttcaa ggctgcccgg gccctgctgg gctgtgccaa     3060

ggcagagtct ggtccagcca gcctgaccat ctgtgagaag gccagtgggt acctgcagga     3120

cagcctggct accacaccag ccagcagctc cattgacaag gccgtgcagc tgttcctgtg     3180

tgacctgctt cttgtggtgc gcaccagcct gtggcggcag cagcagcccc cggccccggc     3240

cccagcagcc cagggcacca gcagcaggcc ccaggcttcc gcccttgagc tgcgtggctt     3300

ccaacgggac ctgagcagcc tgaggcggct ggcacagagc ttccggcccg ccatgcggag     3360

ggtgttccta catgaggcca cggcccggct gatggcgggg gccagcccca cacggacaca     3420

ccagctcctc gaccgcagtc tgaggcggcg ggcaggcccc ggtggcaaag gaggcgcggt     3480

ggcggagctg gagccgcggc ccacgcggcg ggagcacgcg gaggccttgc tgctggcctc     3540

ctgctacctg ccccccggct tcctgtcggc gcccgggcag cgcgtgggca tgctggctga     3600

ggcggcgcgc acactcgaga agcttggcga tcgccggctg ctgcacgact gtcagcagat     3660

gctcatgcgc ctgggcggtg ggaccactgt cacttccagc tagaccccgt gtccccggcc     3720

tcagcacccc tgtctctagc cactttggtc ccgtgcagct tctgtcctgc gtcgaagctt     3780

tgaaggccga aggcagtgca agagactctg gcctccacag ttcgacctgc ggctgctgtg     3840

tgccttcgcg gtggaaggcc cgaggggcgc gatcttgacc ctaagaccgg cggccatgat     3900

ggtgctgacc tctggtggcc gatcggggca ctgcaggggc cgagccattt tggggggccc     3960

ccctccttgc tctgcaggca ccttagtggc ttttttcctc ctgtgtacag ggaagagagg     4020

ggtacatttc cctgtgctga cggaagccaa cttggctttc ccggactgca agcagggctc     4080

tgccccagag gcctctctct ccgtcgtggg agagagacgt gtacatagtg taggtcagcg     4140

tgcttagcct cctgacctga ggctcctgtg ctactttgcc ttttgcaaac tttattttca     4200

tagattgaga agttttgtac agagaattaa aaatgaaatt atttataaaa aaaaaaaaaa     4260

aa                                                                    4262


<210> 7
<211> 1147
<212> PRT
<213> Homo sapiens

<400> 7
Met Asp Glu Pro Pro Phe Ser Glu Ala Ala Leu Glu Gln Ala Leu Gly 
1               5                   10                  15      


Glu Pro Cys Asp Leu Asp Ala Ala Leu Leu Thr Asp Ile Glu Asp Met 
            20                  25                  30          


Leu Gln Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp 
        35                  40                  45              


Pro Pro Tyr Ala Gly Ser Gly Ala Gly Gly Thr Asp Pro Ala Ser Pro 
    50                  55                  60                  


Asp Thr Ser Ser Pro Gly Ser Leu Ser Pro Pro Pro Ala Thr Leu Ser 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Phe Leu Ser Gly Pro Gln Ala Ala Pro Ser Pro 
                85                  90                  95      


Leu Ser Pro Pro Gln Pro Ala Pro Thr Pro Leu Lys Met Tyr Pro Ser 
            100                 105                 110         


Met Pro Ala Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Ser Val Pro 
        115                 120                 125             


Leu Ser Ile Leu Gln Thr Pro Thr Pro Gln Pro Leu Pro Gly Ala Leu 
    130                 135                 140                 


Leu Pro Gln Ser Phe Pro Ala Pro Ala Pro Pro Gln Phe Ser Ser Thr 
145                 150                 155                 160 


Pro Val Leu Gly Tyr Pro Ser Pro Pro Gly Gly Phe Ser Thr Gly Ser 
                165                 170                 175     


Pro Pro Gly Asn Thr Gln Gln Pro Leu Pro Gly Leu Pro Leu Ala Ser 
            180                 185                 190         


Pro Pro Gly Val Pro Pro Val Ser Leu His Thr Gln Val Gln Ser Val 
        195                 200                 205             


Val Pro Gln Gln Leu Leu Thr Val Thr Ala Ala Pro Thr Ala Ala Pro 
    210                 215                 220                 


Val Thr Thr Thr Val Thr Ser Gln Ile Gln Gln Val Pro Val Leu Leu 
225                 230                 235                 240 


Gln Pro His Phe Ile Lys Ala Asp Ser Leu Leu Leu Thr Ala Met Lys 
                245                 250                 255     


Thr Asp Gly Ala Thr Val Lys Ala Ala Gly Leu Ser Pro Leu Val Ser 
            260                 265                 270         


Gly Thr Thr Val Gln Thr Gly Pro Leu Pro Thr Leu Val Ser Gly Gly 
        275                 280                 285             


Thr Ile Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu Pro 
    290                 295                 300                 


Ile Asn Arg Leu Ala Ala Gly Ser Lys Ala Pro Ala Ser Ala Gln Ser 
305                 310                 315                 320 


Arg Gly Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg 
                325                 330                 335     


Ser Ser Ile Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Val Gly 
            340                 345                 350         


Thr Glu Ala Lys Leu Asn Lys Ser Ala Val Leu Arg Lys Ala Ile Asp 
        355                 360                 365             


Tyr Ile Arg Phe Leu Gln His Ser Asn Gln Lys Leu Lys Gln Glu Asn 
    370                 375                 380                 


Leu Ser Leu Arg Thr Ala Val His Lys Ser Lys Ser Leu Lys Asp Leu 
385                 390                 395                 400 


Val Ser Ala Cys Gly Ser Gly Gly Asn Thr Asp Val Leu Met Glu Gly 
                405                 410                 415     


Val Lys Thr Glu Val Glu Asp Thr Leu Thr Pro Pro Pro Ser Asp Ala 
            420                 425                 430         


Gly Ser Pro Phe Gln Ser Ser Pro Leu Ser Leu Gly Ser Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Gly Ser Gly Ser Asp Ser Glu Pro Asp Ser Pro Val Phe 
    450                 455                 460                 


Glu Asp Ser Lys Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg 
465                 470                 475                 480 


Gly Met Leu Asp Arg Ser Arg Leu Ala Leu Cys Thr Leu Val Phe Leu 
                485                 490                 495     


Cys Leu Ser Cys Asn Pro Leu Ala Ser Leu Leu Gly Ala Arg Gly Leu 
            500                 505                 510         


Pro Ser Pro Ser Asp Thr Thr Ser Val Tyr His Ser Pro Gly Arg Asn 
        515                 520                 525             


Val Leu Gly Thr Glu Ser Arg Asp Gly Pro Gly Trp Ala Gln Trp Leu 
    530                 535                 540                 


Leu Pro Pro Val Val Trp Leu Leu Asn Gly Leu Leu Val Leu Val Ser 
545                 550                 555                 560 


Leu Val Leu Leu Phe Val Tyr Gly Glu Pro Val Thr Arg Pro His Ser 
                565                 570                 575     


Gly Pro Ala Val Tyr Phe Trp Arg His Arg Lys Gln Ala Asp Leu Asp 
            580                 585                 590         


Leu Ala Arg Gly Asp Phe Ala Gln Ala Ala Gln Gln Leu Trp Leu Ala 
        595                 600                 605             


Leu Arg Ala Leu Gly Arg Pro Leu Pro Thr Ser His Leu Asp Leu Ala 
    610                 615                 620                 


Cys Ser Leu Leu Trp Asn Leu Ile Arg His Leu Leu Gln Arg Leu Trp 
625                 630                 635                 640 


Val Gly Arg Trp Leu Ala Gly Arg Ala Gly Gly Leu Gln Gln Asp Cys 
                645                 650                 655     


Ala Leu Arg Val Asp Ala Ser Ala Ser Ala Arg Asp Ala Ala Leu Val 
            660                 665                 670         


Tyr His Lys Leu His Gln Leu His Thr Met Gly Lys His Thr Gly Gly 
        675                 680                 685             


His Leu Thr Ala Thr Asn Leu Ala Leu Ser Ala Leu Asn Leu Ala Glu 
    690                 695                 700                 


Cys Ala Gly Asp Ala Val Ser Val Ala Thr Leu Ala Glu Ile Tyr Val 
705                 710                 715                 720 


Ala Ala Ala Leu Arg Val Lys Thr Ser Leu Pro Arg Ala Leu His Phe 
                725                 730                 735     


Leu Thr Arg Phe Phe Leu Ser Ser Ala Arg Gln Ala Cys Leu Ala Gln 
            740                 745                 750         


Ser Gly Ser Val Pro Pro Ala Met Gln Trp Leu Cys His Pro Val Gly 
        755                 760                 765             


His Arg Phe Phe Val Asp Gly Asp Trp Ser Val Leu Ser Thr Pro Trp 
    770                 775                 780                 


Glu Ser Leu Tyr Ser Leu Ala Gly Asn Pro Val Asp Pro Leu Ala Gln 
785                 790                 795                 800 


Val Thr Gln Leu Phe Arg Glu His Leu Leu Glu Arg Ala Leu Asn Cys 
                805                 810                 815     


Val Thr Gln Pro Asn Pro Ser Pro Gly Ser Ala Asp Gly Asp Lys Glu 
            820                 825                 830         


Phe Ser Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser Cys Ser Asp 
        835                 840                 845             


Ala Ala Gly Ala Pro Ala Tyr Ser Phe Ser Ile Ser Ser Ser Met Ala 
    850                 855                 860                 


Thr Thr Thr Gly Val Asp Pro Val Ala Lys Trp Trp Ala Ser Leu Thr 
865                 870                 875                 880 


Ala Val Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala Ala Glu Arg 
                885                 890                 895     


Leu Cys Pro Leu Val Glu His Leu Pro Arg Val Leu Gln Glu Ser Glu 
            900                 905                 910         


Arg Pro Leu Pro Arg Ala Ala Leu His Ser Phe Lys Ala Ala Arg Ala 
        915                 920                 925             


Leu Leu Gly Cys Ala Lys Ala Glu Ser Gly Pro Ala Ser Leu Thr Ile 
    930                 935                 940                 


Cys Glu Lys Ala Ser Gly Tyr Leu Gln Asp Ser Leu Ala Thr Thr Pro 
945                 950                 955                 960 


Ala Ser Ser Ser Ile Asp Lys Ala Val Gln Leu Phe Leu Cys Asp Leu 
                965                 970                 975     


Leu Leu Val Val Arg Thr Ser Leu Trp Arg Gln Gln Gln Pro Pro Ala 
            980                 985                 990         


Pro Ala Pro Ala Ala Gln Gly Thr  Ser Ser Arg Pro Gln  Ala Ser Ala 
        995                 1000                 1005             


Leu Glu  Leu Arg Gly Phe Gln  Arg Asp Leu Ser Ser  Leu Arg Arg 
    1010                 1015                 1020             


Leu Ala  Gln Ser Phe Arg Pro  Ala Met Arg Arg Val  Phe Leu His 
    1025                 1030                 1035             


Glu Ala  Thr Ala Arg Leu Met  Ala Gly Ala Ser Pro  Thr Arg Thr 
    1040                 1045                 1050             


His Gln  Leu Leu Asp Arg Ser  Leu Arg Arg Arg Ala  Gly Pro Gly 
    1055                 1060                 1065             


Gly Lys  Gly Gly Ala Val Ala  Glu Leu Glu Pro Arg  Pro Thr Arg 
    1070                 1075                 1080             


Arg Glu  His Ala Glu Ala Leu  Leu Leu Ala Ser Cys  Tyr Leu Pro 
    1085                 1090                 1095             


Pro Gly  Phe Leu Ser Ala Pro  Gly Gln Arg Val Gly  Met Leu Ala 
    1100                 1105                 1110             


Glu Ala  Ala Arg Thr Leu Glu  Lys Leu Gly Asp Arg  Arg Leu Leu 
    1115                 1120                 1125             


His Asp  Cys Gln Gln Met Leu  Met Arg Leu Gly Gly  Gly Thr Thr 
    1130                 1135                 1140             


Val Thr  Ser Ser 
    1145         


