                         SEQUENCE LISTING

<110>  Laboratorios del Dr. ESTEVE S.A.
       Universitat Autnoma de Barcelona
 
<120>  ADENOASSOCIATED VIRUS VECTORS FOR THE TREATMENT OF LYSOSOMAL 
       STORAGE DISORDERS

<130>  PCT2212.5

<150>  EP14382171
<151>  2014-05-14

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp 
            740             


<210>  2
<211>  2232
<212>  DNA
<213>  Homo sapiens

<400>  2
atggaggcgg tggcggtggc cgcggcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgaggcccg ggaggcggcg gccgtgcggg cgctcgtggc ccggctgctg      120

gggccaggcc ccgcggccga cttctccgtg tcggtggagc gcgctctggc tgccaagccg      180

ggcttggaca cctacagcct gggcggcggc ggcgcggcgc gcgtgcgggt gcgcggctcc      240

acgggcgtgg cggccgccgc ggggctgcac cgctacctgc gcgacttctg tggctgccac      300

gtggcctggt ccggctctca gctgcgcctg ccgcggccac tgccagccgt gccgggggag      360

ctgaccgagg ccacgcccaa caggtaccgc tattaccaga atgtgtgcac gcaaagctac      420

tctttcgtgt ggtgggactg ggcccgctgg gagcgagaga tagactggat ggcgctgaat      480

ggcatcaacc tggcactggc ctggagcggc caggaggcca tctggcagcg ggtgtacctg      540

gccttgggcc tgacccaggc agagatcaat gagttcttta ctggtcctgc cttcctggcc      600

tgggggcgaa tgggcaacct gcacacctgg gatggccccc tgcccccctc ctggcacatc      660

aagcagcttt acctgcagca ccgggtcctg gaccagatgc gctccttcgg catgacccca      720

gtgctgcctg cattcgcggg gcatgttccc gaggctgtca ccagggtgtt ccctcaggtc      780

aatgtcacga agatgggcag ttggggccac tttaactgtt cctactcctg ctccttcctt      840

ctggctccgg aagaccccat attccccatc atcgggagcc tcttcctgcg agagctgatc      900

aaagagtttg gcacagacca catctatggg gccgacactt tcaatgagat gcagccacct      960

tcctcagagc cctcctacct tgccgcagcc accactgccg tctatgaggc catgactgca     1020

gtggatactg aggctgtgtg gctgctccaa ggctggctct tccagcacca gccgcagttc     1080

tgggggcccg cccagatcag ggctgtgctg ggagctgtgc cccgtggccg cctcctggtt     1140

ctggacctgt ttgctgagag ccagcctgtg tatacccgca ctgcctcctt ccagggccag     1200

cccttcatct ggtgcatgct gcacaacttt gggggaaacc atggtctttt tggagcccta     1260

gaggctgtga acggaggccc agaagctgcc cgcctcttcc ccaactccac catggtaggc     1320

acgggcatgg cccccgaggg catcagccag aacgaagtgg tctattccct catggctgag     1380

ctgggctggc gaaaggaccc agtgccagat ttggcagcct gggtgaccag ctttgccgcc     1440

cggcggtatg gggtctccca cccggacgca ggggcagcgt ggaggctact gctccggagt     1500

gtgtacaact gctccgggga ggcctgcagg ggccacaatc gtagcccgct ggtcaggcgg     1560

ccgtccctac agatgaatac cagcatctgg tacaaccgat ctgatgtgtt tgaggcctgg     1620

cggctgctgc tcacatctgc tccctccctg gccaccagcc ccgccttccg ctacgacctg     1680

ctggacctca ctcggcaggc agtgcaggag ctggtcagct tgtactatga ggaggcaaga     1740

agcgcctacc tgagcaagga gctggcctcc ctgttgaggg ctggaggcgt cctggcctat     1800

gagctgctgc cggcactgga cgaggtgctg gctagtgaca gccgcttctt gctgggcagc     1860

tggctagagc aggcccgagc agcggcagtc agtgaggccg aggccgattt ctacgagcag     1920

aacagccgct accagctgac cttgtggggg ccagaaggca acatcctgga ctatgccaac     1980

aagcagctgg cggggttggt ggccaactac tacacccctc gctggcggct tttcctggag     2040

gcgctggttg acagtgtggc ccagggcatc cctttccaac agcaccagtt tgacaaaaat     2100

gtcttccaac tggagcaggc cttcgttctc agcaagcaga ggtaccccag ccagccgcga     2160

ggagacactg tggacctggc caagaagatc ttcctcaaat attacccccg ctgggtggcc     2220

ggctcttggt ga                                                         2232


<210>  3
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cohNaGlu nucleotide sequence

<400>  3
atggaagctg tggctgtggc agctgctgtg ggcgtgctgc tgctggcagg cgctggcgga       60

gctgctgggg atgaagctag agaagctgcc gctgtgcggg ccctggtggc tagactgctg      120

ggacctggac ctgccgccga cttctccgtg tctgtggaaa gagccctggc cgccaagcct      180

ggcctggaca catattctct gggcggaggc ggcgctgctc gcgtcagagt gcgaggatct      240

acaggcgtgg ccgctgctgc cggactgcac agatacctga gagacttctg cggctgccat      300

gtggcttgga gcggcagcca gctgagactg cctagacctc tgcctgctgt gcctggcgag      360

ctgacagagg ccacccctaa cagataccgg tactaccaga acgtgtgcac ccagagctac      420

agcttcgtgt ggtgggactg ggccagatgg gagcgcgaga tcgattggat ggccctgaac      480

ggcatcaacc tggccctggc ttggagtggc caggaagcca tctggcagag agtgtacctg      540

gctctgggcc tgacccaggc cgagatcaac gagttcttta ccggccctgc ctttctggcc      600

tggggcagaa tgggcaacct gcacacatgg gacggccccc tgcctcctag ctggcacatc      660

aagcagctgt acctgcagca cagagtgctg gaccagatga gaagcttcgg catgaccccc      720

gtgctgcctg cttttgctgg acacgtgcca gaggccgtga ccagagtgtt cccccaagtg      780

aacgtgacca agatgggcag ctggggccac ttcaactgca gctactcctg cagcttcctg      840

ctggcccccg aggaccccat cttccctatt atcggcagcc tgttcctgcg ggaactgatc      900

aaagagttcg gcaccgacca catctacggc gccgacacct tcaacgagat gcagccccct      960

agcagcgagc cctcttacct ggctgctgcc accacagccg tgtacgaggc catgacagcc     1020

gtggataccg aggccgtgtg gctgctgcag ggatggctgt ttcagcacca gccccagttc     1080

tggggccctg cccagattag agcagtgctg ggcgctgtgc ccagaggcag gctgctggtg     1140

ctggatctgt tcgccgagag ccagcccgtg tacaccagaa ccgctagctt ccagggacag     1200

cccttcatct ggtgcatgct gcacaacttc ggcggcaacc acggcctgtt cggcgctctg     1260

gaagcagtga atggcggccc tgaggccgcc agactgttcc ctaacagcac aatggtggga     1320

accggcatgg cccctgaggg catctctcag aacgaggtgg tgtacagcct gatggccgag     1380

ctgggctggc ggaaggatcc tgtgcctgat ctggccgcct gggtcacaag cttcgccgct     1440

agaagatacg gcgtgtccca ccctgatgct ggcgccgctt ggagactgct gctgagaagc     1500

gtgtacaact gctccggcga ggcctgcagg ggccacaaca gatctccact cgtgcggagg     1560

cccagcctgc agatgaacac cagcatctgg tacaatcgga gcgacgtgtt cgaggcctgg     1620

cgcctgctgc tgacatctgc tcctagcctg gccacctccc ccgccttcag atacgatctg     1680

ctggacctga ccaggcaggc cgtgcaggaa ctggtgtccc tgtactacga ggaagccaga     1740

agcgcctacc tgagcaaaga gctggcctcc ctgctgagag cagggggagt gctggcttac     1800

gaactgctgc cagccctgga tgaggtgctg gctagcgact ccagatttct gctgggctcc     1860

tggctggaac aggccagagc tgccgcagtg tctgaggccg aggccgattt ctacgagcag     1920

aacagcagat accagctgac cctgtggggc ccagagggca acatcctgga ctacgccaac     1980

aaacagctgg ccggcctggt ggccaactac tacacaccta gatggcggct gtttctggaa     2040

gctctggtgg actctgtggc ccagggcatc ccattccagc agcaccagtt cgacaagaac     2100

gtgttccagc tggaacaggc tttcgtgctg agcaagcaga gataccccag ccagcctaga     2160

ggcgacacag tggacctggc caagaagatc tttctgaagt actaccccag atgggtggcc     2220

ggctcttggt ga                                                         2232


<210>  4
<211>  646
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG nucleotide sequence

<400>  4
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgg                     646


<210>  5
<211>  8461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-hNaGlu Nucleotide sequence

<400>  5
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtatg gaggcggtgg cggtggccgc ggcggtgggg gtccttctcc tggccggggc     1980

cgggggcgcg gcaggcgacg aggcccggga ggcggcggcc gtgcgggcgc tcgtggcccg     2040

gctgctgggg ccaggccccg cggccgactt ctccgtgtcg gtggagcgcg ctctggctgc     2100

caagccgggc ttggacacct acagcctggg cggcggcggc gcggcgcgcg tgcgggtgcg     2160

cggctccacg ggcgtggcgg ccgccgcggg gctgcaccgc tacctgcgcg acttctgtgg     2220

ctgccacgtg gcctggtccg gctctcagct gcgcctgccg cggccactgc cagccgtgcc     2280

gggggagctg accgaggcca cgcccaacag gtaccgctat taccagaatg tgtgcacgca     2340

aagctactct ttcgtgtggt gggactgggc ccgctgggag cgagagatag actggatggc     2400

gctgaatggc atcaacctgg cactggcctg gagcggccag gaggccatct ggcagcgggt     2460

gtacctggcc ttgggcctga cccaggcaga gatcaatgag ttctttactg gtcctgcctt     2520

cctggcctgg gggcgaatgg gcaacctgca cacctgggat ggccccctgc ccccctcctg     2580

gcacatcaag cagctttacc tgcagcaccg ggtcctggac cagatgcgct ccttcggcat     2640

gaccccagtg ctgcctgcat tcgcggggca tgttcccgag gctgtcacca gggtgttccc     2700

tcaggtcaat gtcacgaaga tgggcagttg gggccacttt aactgttcct actcctgctc     2760

cttccttctg gctccggaag accccatatt ccccatcatc gggagcctct tcctgcgaga     2820

gctgatcaaa gagtttggca cagaccacat ctatggggcc gacactttca atgagatgca     2880

gccaccttcc tcagagccct cctaccttgc cgcagccacc actgccgtct atgaggccat     2940

gactgcagtg gatactgagg ctgtgtggct gctccaaggc tggctcttcc agcaccagcc     3000

gcagttctgg gggcccgccc agatcagggc tgtgctggga gctgtgcccc gtggccgcct     3060

cctggttctg gacctgtttg ctgagagcca gcctgtgtat acccgcactg cctccttcca     3120

gggccagccc ttcatctggt gcatgctgca caactttggg ggaaaccatg gtctttttgg     3180

agccctagag gctgtgaacg gaggcccaga agctgcccgc ctcttcccca actccaccat     3240

ggtaggcacg ggcatggccc ccgagggcat cagccagaac gaagtggtct attccctcat     3300

ggctgagctg ggctggcgaa aggacccagt gccagatttg gcagcctggg tgaccagctt     3360

tgccgcccgg cggtatgggg tctcccaccc ggacgcaggg gcagcgtgga ggctactgct     3420

ccggagtgtg tacaactgct ccggggaggc ctgcaggggc cacaatcgta gcccgctggt     3480

caggcggccg tccctacaga tgaataccag catctggtac aaccgatctg atgtgtttga     3540

ggcctggcgg ctgctgctca catctgctcc ctccctggcc accagccccg ccttccgcta     3600

cgacctgctg gacctcactc ggcaggcagt gcaggagctg gtcagcttgt actatgagga     3660

ggcaagaagc gcctacctga gcaaggagct ggcctccctg ttgagggctg gaggcgtcct     3720

ggcctatgag ctgctgccgg cactggacga ggtgctggct agtgacagcc gcttcttgct     3780

gggcagctgg ctagagcagg cccgagcagc ggcagtcagt gaggccgagg ccgatttcta     3840

cgagcagaac agccgctacc agctgacctt gtgggggcca gaaggcaaca tcctggacta     3900

tgccaacaag cagctggcgg ggttggtggc caactactac acccctcgct ggcggctttt     3960

cctggaggcg ctggttgaca gtgtggccca gggcatccct ttccaacagc accagtttga     4020

caaaaatgtc ttccaactgg agcaggcctt cgttctcagc aagcagaggt accccagcca     4080

gccgcgagga gacactgtgg acctggccaa gaagatcttc ctcaaatatt acccccgctg     4140

ggtggccggc tcttggtgag aattcgagct cggtacccgg gaatcaattc actcctcagg     4200

tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa tgccctggct cacaaatacc     4260

actgagatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4320

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4380

gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag aatgagtatt     4440

tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa ggttggctat     4500

aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc catagaaaag     4560

ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt tctttaacat     4620

ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc tgactactcc     4680

cagtcatagc tgtccctctt ctcttatgga gatccctcga cctgcagccc aagctgtaga     4740

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4800

tccctctctg cgcgctcgct cgctcactga ggccgcccgg gctttgcccg ggcggcctca     4860

gtgagcgagc gagcgcgcag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     4920

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     4980

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     5040

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     5100

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     5160

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     5220

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     5280

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     5340

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     5400

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     5460

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     5520

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     5580

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     5640

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     5700

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     5760

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     5820

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     5880

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     5940

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     6000

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     6060

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     6120

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     6180

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     6240

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     6300

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     6360

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     6420

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     6480

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     6540

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     6600

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     6660

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     6720

aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt     6780

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     6840

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     6900

cctataaaaa taggcgtatc acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg     6960

aaaacctctg acacatgcag ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg     7020

ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta     7080

actatgcggc atcagagcag attgtactga gagtgcacca tatgcggtgt gaaataccgc     7140

acagatgcgt aaggagaaaa taccgcatca ggcgattcca acatccaata aatcatacag     7200

gcaaggcaaa gaattagcaa aattaagcaa taaagcctca gagcataaag ctaaatcggt     7260

tgtaccaaaa acattatgac cctgtaatac ttttgcggga gaagccttta tttcaacgca     7320

aggataaaaa tttttagaac cctcatatat tttaaatgca atgcctgagt aatgtgtagg     7380

taaagattca aacgggtgag aaaggccgga gacagtcaaa tcaccatcaa tatgatattc     7440

aaccgttcta gctgataaat tcatgccgga gagggtagct atttttgaga ggtctctaca     7500

aaggctatca ggtcattgcc tgagagtctg gagcaaacaa gagaatcgat gaacggtaat     7560

cgtaaaacta gcatgtcaat catatgtacc ccggttgata atcagaaaag ccccaaaaac     7620

aggaagattg tataagcaaa tatttaaatt gtaagcgtta atattttgtt aaaattcgcg     7680

ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg caaaatccct     7740

tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt     7800

ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat     7860

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca     7920

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac     7980

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta     8040

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg     8100

tactatggtt gctttgacga gcacgtataa cgtgctttcc tcgttagaat cagagcggga     8160

gctaaacagg aggccgatta aagggatttt agacaggaac ggtacgccag aatcctgaga     8220

agtgttttta taatcagtga ggccaccgag taaaagagtc tgtccatcac gcaaattaac     8280

cgttgtcgca atacttcttt gattagtaat aacatcactt gcctgagtag aagaactcaa     8340

actatcggcc ttgctggtaa tatccagaac aatattaccg ccagccattg caacggaatc     8400

gccattcgcc attcaggctg cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc     8460

t                                                                     8461


<210>  6
<211>  8467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-cohNaGlu Nucleotide sequence

<400>  6
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatggaag ctgtggctgt ggcagctgct gtgggcgtgc tgctgctggc     1980

aggcgctggc ggagctgctg gggatgaagc tagagaagct gccgctgtgc gggccctggt     2040

ggctagactg ctgggacctg gacctgccgc cgacttctcc gtgtctgtgg aaagagccct     2100

ggccgccaag cctggcctgg acacatattc tctgggcgga ggcggcgctg ctcgcgtcag     2160

agtgcgagga tctacaggcg tggccgctgc tgccggactg cacagatacc tgagagactt     2220

ctgcggctgc catgtggctt ggagcggcag ccagctgaga ctgcctagac ctctgcctgc     2280

tgtgcctggc gagctgacag aggccacccc taacagatac cggtactacc agaacgtgtg     2340

cacccagagc tacagcttcg tgtggtggga ctgggccaga tgggagcgcg agatcgattg     2400

gatggccctg aacggcatca acctggccct ggcttggagt ggccaggaag ccatctggca     2460

gagagtgtac ctggctctgg gcctgaccca ggccgagatc aacgagttct ttaccggccc     2520

tgcctttctg gcctggggca gaatgggcaa cctgcacaca tgggacggcc ccctgcctcc     2580

tagctggcac atcaagcagc tgtacctgca gcacagagtg ctggaccaga tgagaagctt     2640

cggcatgacc cccgtgctgc ctgcttttgc tggacacgtg ccagaggccg tgaccagagt     2700

gttcccccaa gtgaacgtga ccaagatggg cagctggggc cacttcaact gcagctactc     2760

ctgcagcttc ctgctggccc ccgaggaccc catcttccct attatcggca gcctgttcct     2820

gcgggaactg atcaaagagt tcggcaccga ccacatctac ggcgccgaca ccttcaacga     2880

gatgcagccc cctagcagcg agccctctta cctggctgct gccaccacag ccgtgtacga     2940

ggccatgaca gccgtggata ccgaggccgt gtggctgctg cagggatggc tgtttcagca     3000

ccagccccag ttctggggcc ctgcccagat tagagcagtg ctgggcgctg tgcccagagg     3060

caggctgctg gtgctggatc tgttcgccga gagccagccc gtgtacacca gaaccgctag     3120

cttccaggga cagcccttca tctggtgcat gctgcacaac ttcggcggca accacggcct     3180

gttcggcgct ctggaagcag tgaatggcgg ccctgaggcc gccagactgt tccctaacag     3240

cacaatggtg ggaaccggca tggcccctga gggcatctct cagaacgagg tggtgtacag     3300

cctgatggcc gagctgggct ggcggaagga tcctgtgcct gatctggccg cctgggtcac     3360

aagcttcgcc gctagaagat acggcgtgtc ccaccctgat gctggcgccg cttggagact     3420

gctgctgaga agcgtgtaca actgctccgg cgaggcctgc aggggccaca acagatctcc     3480

actcgtgcgg aggcccagcc tgcagatgaa caccagcatc tggtacaatc ggagcgacgt     3540

gttcgaggcc tggcgcctgc tgctgacatc tgctcctagc ctggccacct cccccgcctt     3600

cagatacgat ctgctggacc tgaccaggca ggccgtgcag gaactggtgt ccctgtacta     3660

cgaggaagcc agaagcgcct acctgagcaa agagctggcc tccctgctga gagcaggggg     3720

agtgctggct tacgaactgc tgccagccct ggatgaggtg ctggctagcg actccagatt     3780

tctgctgggc tcctggctgg aacaggccag agctgccgca gtgtctgagg ccgaggccga     3840

tttctacgag cagaacagca gataccagct gaccctgtgg ggcccagagg gcaacatcct     3900

ggactacgcc aacaaacagc tggccggcct ggtggccaac tactacacac ctagatggcg     3960

gctgtttctg gaagctctgg tggactctgt ggcccagggc atcccattcc agcagcacca     4020

gttcgacaag aacgtgttcc agctggaaca ggctttcgtg ctgagcaagc agagataccc     4080

cagccagcct agaggcgaca cagtggacct ggccaagaag atctttctga agtactaccc     4140

cagatgggtg gccggctctt ggtgagaatt cgagctcggt acccgggaat caattcactc     4200

ctcaggtgca ggctgcctat cagaaggtgg tggctggtgt ggccaatgcc ctggctcaca     4260

aataccactg agatcttttt ccctctgcca aaaattatgg ggacatcatg aagccccttg     4320

agcatctgac ttctggctaa taaaggaaat ttattttcat tgcaatagtg tgttggaatt     4380

ttttgtgtct ctcactcgga aggacatatg ggagggcaaa tcatttaaaa catcagaatg     4440

agtatttggt ttagagtttg gcaacatatg cccatatgct ggctgccatg aacaaaggtt     4500

ggctataaag aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata     4560

gaaaagcctt gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt     4620

taacatccct aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac     4680

tactcccagt catagctgtc cctcttctct tatggagatc cctcgacctg cagcccaagc     4740

tgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     4800

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggctt tgcccgggcg     4860

gcctcagtga gcgagcgagc gcgcagctgc attaatgaat cggccaacgc gcggggagag     4920

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     4980

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     5040

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     5100

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     5160

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     5220

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     5280

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     5340

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     5400

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     5460

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     5520

cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct     5580

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     5640

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     5700

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     5760

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     5820

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     5880

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     5940

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     6000

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     6060

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     6120

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     6180

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     6240

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     6300

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     6360

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     6420

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     6480

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     6540

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     6600

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     6660

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     6720

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     6780

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     6840

ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt attatcatga     6900

cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt ttcggtgatg     6960

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     7020

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggct     7080

ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa     7140

taccgcacag atgcgtaagg agaaaatacc gcatcaggcg attccaacat ccaataaatc     7200

atacaggcaa ggcaaagaat tagcaaaatt aagcaataaa gcctcagagc ataaagctaa     7260

atcggttgta ccaaaaacat tatgaccctg taatactttt gcgggagaag cctttatttc     7320

aacgcaagga taaaaatttt tagaaccctc atatatttta aatgcaatgc ctgagtaatg     7380

tgtaggtaaa gattcaaacg ggtgagaaag gccggagaca gtcaaatcac catcaatatg     7440

atattcaacc gttctagctg ataaattcat gccggagagg gtagctattt ttgagaggtc     7500

tctacaaagg ctatcaggtc attgcctgag agtctggagc aaacaagaga atcgatgaac     7560

ggtaatcgta aaactagcat gtcaatcata tgtaccccgg ttgataatca gaaaagcccc     7620

aaaaacagga agattgtata agcaaatatt taaattgtaa gcgttaatat tttgttaaaa     7680

ttcgcgttaa atttttgtta aatcagctca ttttttaacc aataggccga aatcggcaaa     7740

atcccttata aatcaaaaga atagaccgag atagggttga gtgttgttcc agtttggaac     7800

aagagtccac tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac cgtctatcag     7860

ggcgatggcc cactacgtga accatcaccc taatcaagtt ttttggggtc gaggtgccgt     7920

aaagcactaa atcggaaccc taaagggagc ccccgattta gagcttgacg gggaaagccg     7980

gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag cgggcgctag ggcgctggca     8040

agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg cgcttaatgc gccgctacag     8100

ggcgcgtact atggttgctt tgacgagcac gtataacgtg ctttcctcgt tagaatcaga     8160

gcgggagcta aacaggaggc cgattaaagg gattttagac aggaacggta cgccagaatc     8220

ctgagaagtg tttttataat cagtgaggcc accgagtaaa agagtctgtc catcacgcaa     8280

attaaccgtt gtcgcaatac ttctttgatt agtaataaca tcacttgcct gagtagaaga     8340

actcaaacta tcggccttgc tggtaatatc cagaacaata ttaccgccag ccattgcaac     8400

ggaatcgcca ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct     8460

cttcgct                                                               8467


<210>  7
<211>  8472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-comNaGlu Nucleotide sequence

<400>  7
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgct agcgccacca tggaagctgc cggcctggcc gtgatcctgg gctttctgct     1980

gctggctggc ggctctgtgg gcgacgaggc cagagaagcc aaggctgtgc gcgagctggt     2040

cgtgcgcctg ctgggacctg gccctgccgc caacttcctg gtgtccgtgg aaagagccct     2100

ggccgacgag agcggcctgg acacatacag cctgtctggc ggcggaggcg tgccagttct     2160

ggtgcgcgga tctacaggcg tggccgctgc cgctggcctg cacagatacc tgagagactt     2220

ctgcggctgc caggtggcct ggtccagcgc tcagctgcat ctgccttggc ccctgcctgc     2280

cgtgcctgac ggcctgaccg agacaacccc caacagatac cggtactacc agaacgtgtg     2340

cacccacagc tacagcttcg tctggtggga ctgggccaga tgggagcaag aaatcgactg     2400

gatggccctg aacggcatca acctggctct ggcctggaac ggccaagaag ccatctggca     2460

gagagtgtat ctggccctgg gcctgaccca gagcgagatc gacacctact tcaccggccc     2520

tgcctttctg gcttggggca gaatgggcaa cctgcacacc tgggacggcc ccctgcccag     2580

aagctggcac ctgagccagg tgtacctgca gcacagaatc ctggacagaa tgagaagctt     2640

cggcatgatc cccgtgctgc ccgccttcgc tggccacgtg cccaaggcca tcaccagagt     2700

gttcccccaa gtgaacgtga tcaagctggg cagctggggc cacttcaact gcagctactc     2760

ctgcagcttc ctgctggccc ctggcgaccc catgttcccc ctgatcggca acctgttcct     2820

gagagagctg accaaagagt tcggcaccga ccacatctac ggcgccgaca ccttcaacga     2880

gatgcagccc cccttcagcg acccctctta cctggccgcc accacagccg ccgtgtacga     2940

ggccatggtg acagtggacc ccgacgccgt gtggctgctg cagggctggc tgttccagca     3000

ccagccccag ttctggggac ctagccagat cagagccgtg ctggaagccg tgcccagagg     3060

cagactgctg gtgctggacc tgttcgccga gagccacccc gtgtacatgc acaccgccag     3120

cttccacggc cagcccttca tctggtgcat gctgcacaac ttcggcggca accacggcct     3180

gttcggcgcc ctggaagatg tgaacagagg cccccaggcc gccagactgt tccccaacag     3240

caccatggtc ggaaccggaa tcgcccccga gggcatcggc cagaacgagg tggtgtacgc     3300

cctgatggcc gagctgggct ggcggaagga ccctgtgcct gacctgatgg cctgggtgtc     3360

cagcttcgcc atcagacgct acggcgtgtc ccagcctgat gccgtggccg cttggaagct     3420

gctgctgaga agcgtgtaca actgcagcgg cgaggcctgc agcggccaca acagatcccc     3480

cctggtgaaa agacccagcc tgcagatgag caccgccgtg tggtacaacc gcagcgacgt     3540

gttcgaggcc tggcgcctgc tgctgacagc cgcccctaac ctgaccacct cccccgcctt     3600

cagatacgac ctgctggacg tgaccagaca ggccgtgcaa gaactggtgt ccctgtgcta     3660

cgaggaagcc agaaccgcct acctgaaaca agaactggac ctgctcctgc gggcaggcgg     3720

cctgctggtg tacaagctgc tgcccaccct ggacgagctg ctggccagct ctagccactt     3780

tctgctgggc acatggctgg accaggccag aaaggccgct gtgtctgagg ccgaggccca     3840

gttctacgag cagaacagca gataccagat caccctgtgg ggccctgagg gcaacatcct     3900

ggactacgcc aacaagcagc tggctggcct ggtggccgac tactaccagc ccagatggtg     3960

cctgttcctg ggcaccctgg cccacagcct ggctagaggc gtgcccttcc agcagcacga     4020

gttcgagaag aacgtgttcc ctctggaaca ggccttcgtg tacaacaaga agagataccc     4080

cagccagccc agaggcgaca ccgtggacct gagcaagaag atcttcctga agtaccaccc     4140

ccagcccgac agcctgtgat gagcggccgc gaattcgagc tcggtacccg ggaatcaatt     4200

cactcctcag gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca atgccctggc     4260

tcacaaatac cactgagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     4320

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     4380

gaattttttg tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca     4440

gaatgagtat ttggtttaga gtttggcaac atatgcccat atgctggctg ccatgaacaa     4500

aggttggcta taaagaggtc atcagtatat gaaacagccc cctgctgtcc attccttatt     4560

ccatagaaaa gccttgactt gaggttagat tttttttata ttttgttttg tgttattttt     4620

ttctttaaca tccctaaaat tttccttaca tgttttacta gccagatttt tcctcctctc     4680

ctgactactc ccagtcatag ctgtccctct tctcttatgg agatccctcg acctgcagcc     4740

caagctgtag ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg     4800

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggctttgccc     4860

gggcggcctc agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg     4920

gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc     4980

ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac     5040

agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa     5100

ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca     5160

caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc     5220

gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata     5280

cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta     5340

tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca     5400

gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga     5460

cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg     5520

tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg     5580

tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg     5640

caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag     5700

aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa     5760

cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat     5820

ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc     5880

tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc     5940

atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc     6000

tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc     6060

aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc     6120

catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt     6180

gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc     6240

ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa     6300

aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt     6360

atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg     6420

cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc     6480

gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa     6540

agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt     6600

gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt     6660

caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag     6720

ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta     6780

tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat     6840

aggggttccg cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat     6900

catgacatta acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg     6960

tgatgacggt gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta     7020

agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg     7080

gggctggctt aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg     7140

tgaaataccg cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat     7200

aaatcataca ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa     7260

gctaaatcgg ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt     7320

atttcaacgc aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag     7380

taatgtgtag gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca     7440

atatgatatt caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag     7500

aggtctctac aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga     7560

tgaacggtaa tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa     7620

gccccaaaaa caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt     7680

taaaattcgc gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg     7740

gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt     7800

ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct     7860

atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt     7920

gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa     7980

agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc     8040

tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc     8100

tacagggcgc gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa     8160

tcagagcggg agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca     8220

gaatcctgag aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca     8280

cgcaaattaa ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta     8340

gaagaactca aactatcggc cttgctggta atatccagaa caatattacc gccagccatt     8400

gcaacggaat cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg     8460

ggcctcttcg ct                                                         8472


<210>  8
<211>  8479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-cocNaGlu Nucleotide sequence

<400>  8
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgggag ctgccgctgc tgctgctgtc ctgggcctcc tgctcctggg     1980

agctgctggc ggagccgccg ctgatgaagc cagagaagcc gctgccgtgc gggctctgct     2040

cgtcagactg ctgggacctg gacccgcagc tgccttcagc gtgtccgtga aaagagccct     2100

ggccgccgag agcggcctgg acacctatag actgtctggc ggcggagccg gcaccagggt     2160

gctggtgctg ggatctacag gtgtcgccgc tgccgccgga ctgcacagat acctgaggga     2220

cttctgcggc tgccatgtgg cttggagcgg cagccagctg agactgcctg agcctctgcc     2280

tgccgtgcct caggtgctga ccgaggccac ccccaacaga taccggtact accagaacgt     2340

gtgcacccac agctacagct tcgtctggtg ggactgggcc agatgggagc gcgagctgga     2400

ctggatggcc ctgaacggca tcaacctggc tctcgcttgg agtggccagg aagccatctg     2460

gcagagggtg tacctggccc tgggcctgac ccagagcgag atcgacgagt acttcaccgg     2520

ccctgccttt ctggcctggg gcaggatggg caacctgcac acctggggcg gacccctgcc     2580

tcacagctgg cacctgaagc agctgtacct gcagcacagg atcctggaca ggatgcggag     2640

cttcggcatg atccccgtgc tgcccgcctt cagcggccac gtgccaaagg ccctgaccag     2700

ggtgttcccc cagatcaaca tcacacagct cggaagttgg ggccacttca actgcagcta     2760

ctcctgcagc ttcctgctgg cccccgagga ccccctgttc cctatcatcg gcagcctgtt     2820

tctgagagag ctgatccagg aatttggcac caaccacatc tacggcgccg acaccttcaa     2880

cgagatgcag ccccccagca gcgagcccag ctacctggcc tctgccaccg ccagcgtgta     2940

ccaggccatg atcaccgtgg acagcgacgc cgtgtggctg ctgcagggct ggctgttcca     3000

gcaccagcct cagttctggg gccctgccca ggtcaaagcc gtgctggaag ccgtgcccag     3060

gggcaggctg ctcgtgctgg atctgttcgc cgagagccag cccgtgtaca tccagaccgc     3120

cagcttccag ggccagccct tcatctggtg catgctgcac aacttcggcg gcaaccacgg     3180

cctgttcgga gccctcgagg ccgtgaatag aggcccagcc gccgctaggc tgttccccaa     3240

ctctaccatg ctgggcaccg gaatggcccc tgagggcatc ggccagaacg aggtggtgta     3300

cgccctgatg gccgagctgg gctggcggaa ggatcccgtg gccgatctgg aagcctgggt     3360

gtccagcttc gccgctcgga gatacggcgt ggcccacaga gataccgaag ccgcctggag     3420

actgctgctg agaagcgtgt acaactgcag cggcgaggcc tgctccggcc acaacagatc     3480

tccactcgtg cggaggccct ccctgcagat ggtcaccacc gtgtggtata accgcagcga     3540

cgtgttcgag gcttggagac tgctgctgac cgccgctcct accctggcca gcagccccac     3600

cttcagatac gacctgctgg acgtgaccag gcaggccgcc caggaactcg tcagcctgta     3660

ctacgtggaa gccagaagcg cctacctgcg gaaagaactg gtgcccctgc tgagggccgc     3720

tggcgtgctg gtgtatgagc tgctgcctgc cctggacaag gtgctggcta gcgactcccg     3780

gttcctgctg ggcagatggc tggaacaggc cagggctgcc gccgtgtctg aagccgaggc     3840

ccacctgtac gagcagaaca gcagatacca gctgaccctg tggggacccg agggcaacat     3900

cctggactac gccaacaagc agctggccgg cctggtggcc gactactaca cccccagatg     3960

gcggctgttc atggaaatgc tggtggaaag cctggtgcag ggcatcccat tccagcagca     4020

ccagttcgac aagaacgcct tccagctcga gcagaccttc atcttcggca cccagagata     4080

ccccagccag cccgacggcg acaccgtgga cctggccaag aagctgttca tcaagtacta     4140

ccccaggctg gtggccggct ccctgtgggc cgattgagaa ttcgagctcg gtacccggga     4200

atcaattcac tcctcaggtg caggctgcct atcagaaggt ggtggctggt gtggccaatg     4260

ccctggctca caaataccac tgagatcttt ttccctctgc caaaaattat ggggacatca     4320

tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag     4380

tgtgttggaa ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttaa     4440

aacatcagaa tgagtatttg gtttagagtt tggcaacata tgcccatatg ctggctgcca     4500

tgaacaaagg ttggctataa agaggtcatc agtatatgaa acagccccct gctgtccatt     4560

ccttattcca tagaaaagcc ttgacttgag gttagatttt ttttatattt tgttttgtgt     4620

tatttttttc tttaacatcc ctaaaatttt ccttacatgt tttactagcc agatttttcc     4680

tcctctcctg actactccca gtcatagctg tccctcttct cttatggaga tccctcgacc     4740

tgcagcccaa gctgtagata agtagcatgg cgggttaatc attaactaca aggaacccct     4800

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc     4860

tttgcccggg cggcctcagt gagcgagcga gcgcgcagct gcattaatga atcggccaac     4920

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     4980

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     5040

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     5100

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     5160

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     5220

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     5280

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct     5340

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     5400

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     5460

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     5520

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag     5580

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     5640

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     5700

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     5760

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     5820

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     5880

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     5940

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     6000

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     6060

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     6120

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     6180

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     6240

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     6300

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     6360

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     6420

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     6480

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     6540

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     6600

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     6660

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     6720

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa     6780

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     6840

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca     6900

ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc     6960

gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt     7020

gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg     7080

ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata     7140

tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgattccaac     7200

atccaataaa tcatacaggc aaggcaaaga attagcaaaa ttaagcaata aagcctcaga     7260

gcataaagct aaatcggttg taccaaaaac attatgaccc tgtaatactt ttgcgggaga     7320

agcctttatt tcaacgcaag gataaaaatt tttagaaccc tcatatattt taaatgcaat     7380

gcctgagtaa tgtgtaggta aagattcaaa cgggtgagaa aggccggaga cagtcaaatc     7440

accatcaata tgatattcaa ccgttctagc tgataaattc atgccggaga gggtagctat     7500

ttttgagagg tctctacaaa ggctatcagg tcattgcctg agagtctgga gcaaacaaga     7560

gaatcgatga acggtaatcg taaaactagc atgtcaatca tatgtacccc ggttgataat     7620

cagaaaagcc ccaaaaacag gaagattgta taagcaaata tttaaattgt aagcgttaat     7680

attttgttaa aattcgcgtt aaatttttgt taaatcagct cattttttaa ccaataggcc     7740

gaaatcggca aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt     7800

ccagtttgga acaagagtcc actattaaag aacgtggact ccaacgtcaa agggcgaaaa     7860

accgtctatc agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg     7920

tcgaggtgcc gtaaagcact aaatcggaac cctaaaggga gcccccgatt tagagcttga     7980

cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct     8040

agggcgctgg caagtgtagc ggtcacgctg cgcgtaacca ccacacccgc cgcgcttaat     8100

gcgccgctac agggcgcgta ctatggttgc tttgacgagc acgtataacg tgctttcctc     8160

gttagaatca gagcgggagc taaacaggag gccgattaaa gggattttag acaggaacgg     8220

tacgccagaa tcctgagaag tgtttttata atcagtgagg ccaccgagta aaagagtctg     8280

tccatcacgc aaattaaccg ttgtcgcaat acttctttga ttagtaataa catcacttgc     8340

ctgagtagaa gaactcaaac tatcggcctt gctggtaata tccagaacaa tattaccgcc     8400

agccattgca acggaatcgc cattcgccat tcaggctgcg caactgttgg gaagggcgat     8460

cggtgcgggc ctcttcgct                                                  8479


<210>  9
<211>  4880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-hNaGlu Nucleotide sequence

<400>  9
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtatg gaggcggtgg cggtggccgc ggcggtgggg gtccttctcc tggccggggc     1980

cgggggcgcg gcaggcgacg aggcccggga ggcggcggcc gtgcgggcgc tcgtggcccg     2040

gctgctgggg ccaggccccg cggccgactt ctccgtgtcg gtggagcgcg ctctggctgc     2100

caagccgggc ttggacacct acagcctggg cggcggcggc gcggcgcgcg tgcgggtgcg     2160

cggctccacg ggcgtggcgg ccgccgcggg gctgcaccgc tacctgcgcg acttctgtgg     2220

ctgccacgtg gcctggtccg gctctcagct gcgcctgccg cggccactgc cagccgtgcc     2280

gggggagctg accgaggcca cgcccaacag gtaccgctat taccagaatg tgtgcacgca     2340

aagctactct ttcgtgtggt gggactgggc ccgctgggag cgagagatag actggatggc     2400

gctgaatggc atcaacctgg cactggcctg gagcggccag gaggccatct ggcagcgggt     2460

gtacctggcc ttgggcctga cccaggcaga gatcaatgag ttctttactg gtcctgcctt     2520

cctggcctgg gggcgaatgg gcaacctgca cacctgggat ggccccctgc ccccctcctg     2580

gcacatcaag cagctttacc tgcagcaccg ggtcctggac cagatgcgct ccttcggcat     2640

gaccccagtg ctgcctgcat tcgcggggca tgttcccgag gctgtcacca gggtgttccc     2700

tcaggtcaat gtcacgaaga tgggcagttg gggccacttt aactgttcct actcctgctc     2760

cttccttctg gctccggaag accccatatt ccccatcatc gggagcctct tcctgcgaga     2820

gctgatcaaa gagtttggca cagaccacat ctatggggcc gacactttca atgagatgca     2880

gccaccttcc tcagagccct cctaccttgc cgcagccacc actgccgtct atgaggccat     2940

gactgcagtg gatactgagg ctgtgtggct gctccaaggc tggctcttcc agcaccagcc     3000

gcagttctgg gggcccgccc agatcagggc tgtgctggga gctgtgcccc gtggccgcct     3060

cctggttctg gacctgtttg ctgagagcca gcctgtgtat acccgcactg cctccttcca     3120

gggccagccc ttcatctggt gcatgctgca caactttggg ggaaaccatg gtctttttgg     3180

agccctagag gctgtgaacg gaggcccaga agctgcccgc ctcttcccca actccaccat     3240

ggtaggcacg ggcatggccc ccgagggcat cagccagaac gaagtggtct attccctcat     3300

ggctgagctg ggctggcgaa aggacccagt gccagatttg gcagcctggg tgaccagctt     3360

tgccgcccgg cggtatgggg tctcccaccc ggacgcaggg gcagcgtgga ggctactgct     3420

ccggagtgtg tacaactgct ccggggaggc ctgcaggggc cacaatcgta gcccgctggt     3480

caggcggccg tccctacaga tgaataccag catctggtac aaccgatctg atgtgtttga     3540

ggcctggcgg ctgctgctca catctgctcc ctccctggcc accagccccg ccttccgcta     3600

cgacctgctg gacctcactc ggcaggcagt gcaggagctg gtcagcttgt actatgagga     3660

ggcaagaagc gcctacctga gcaaggagct ggcctccctg ttgagggctg gaggcgtcct     3720

ggcctatgag ctgctgccgg cactggacga ggtgctggct agtgacagcc gcttcttgct     3780

gggcagctgg ctagagcagg cccgagcagc ggcagtcagt gaggccgagg ccgatttcta     3840

cgagcagaac agccgctacc agctgacctt gtgggggcca gaaggcaaca tcctggacta     3900

tgccaacaag cagctggcgg ggttggtggc caactactac acccctcgct ggcggctttt     3960

cctggaggcg ctggttgaca gtgtggccca gggcatccct ttccaacagc accagtttga     4020

caaaaatgtc ttccaactgg agcaggcctt cgttctcagc aagcagaggt accccagcca     4080

gccgcgagga gacactgtgg acctggccaa gaagatcttc ctcaaatatt acccccgctg     4140

ggtggccggc tcttggtgag aattcgagct cggtacccgg gaatcaattc actcctcagg     4200

tgcaggctgc ctatcagaag gtggtggctg gtgtggccaa tgccctggct cacaaatacc     4260

actgagatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4320

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4380

gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag aatgagtatt     4440

tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa ggttggctat     4500

aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc catagaaaag     4560

ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt tctttaacat     4620

ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc tgactactcc     4680

cagtcatagc tgtccctctt ctcttatgga gatccctcga cctgcagccc aagctgtaga     4740

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4800

tccctctctg cgcgctcgct cgctcactga ggccgcccgg gctttgcccg ggcggcctca     4860

gtgagcgagc gagcgcgcag                                                 4880


<210>  10
<211>  4886
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-cohNaGlu Nucleotide sequence

<400>  10
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatggaag ctgtggctgt ggcagctgct gtgggcgtgc tgctgctggc     1980

aggcgctggc ggagctgctg gggatgaagc tagagaagct gccgctgtgc gggccctggt     2040

ggctagactg ctgggacctg gacctgccgc cgacttctcc gtgtctgtgg aaagagccct     2100

ggccgccaag cctggcctgg acacatattc tctgggcgga ggcggcgctg ctcgcgtcag     2160

agtgcgagga tctacaggcg tggccgctgc tgccggactg cacagatacc tgagagactt     2220

ctgcggctgc catgtggctt ggagcggcag ccagctgaga ctgcctagac ctctgcctgc     2280

tgtgcctggc gagctgacag aggccacccc taacagatac cggtactacc agaacgtgtg     2340

cacccagagc tacagcttcg tgtggtggga ctgggccaga tgggagcgcg agatcgattg     2400

gatggccctg aacggcatca acctggccct ggcttggagt ggccaggaag ccatctggca     2460

gagagtgtac ctggctctgg gcctgaccca ggccgagatc aacgagttct ttaccggccc     2520

tgcctttctg gcctggggca gaatgggcaa cctgcacaca tgggacggcc ccctgcctcc     2580

tagctggcac atcaagcagc tgtacctgca gcacagagtg ctggaccaga tgagaagctt     2640

cggcatgacc cccgtgctgc ctgcttttgc tggacacgtg ccagaggccg tgaccagagt     2700

gttcccccaa gtgaacgtga ccaagatggg cagctggggc cacttcaact gcagctactc     2760

ctgcagcttc ctgctggccc ccgaggaccc catcttccct attatcggca gcctgttcct     2820

gcgggaactg atcaaagagt tcggcaccga ccacatctac ggcgccgaca ccttcaacga     2880

gatgcagccc cctagcagcg agccctctta cctggctgct gccaccacag ccgtgtacga     2940

ggccatgaca gccgtggata ccgaggccgt gtggctgctg cagggatggc tgtttcagca     3000

ccagccccag ttctggggcc ctgcccagat tagagcagtg ctgggcgctg tgcccagagg     3060

caggctgctg gtgctggatc tgttcgccga gagccagccc gtgtacacca gaaccgctag     3120

cttccaggga cagcccttca tctggtgcat gctgcacaac ttcggcggca accacggcct     3180

gttcggcgct ctggaagcag tgaatggcgg ccctgaggcc gccagactgt tccctaacag     3240

cacaatggtg ggaaccggca tggcccctga gggcatctct cagaacgagg tggtgtacag     3300

cctgatggcc gagctgggct ggcggaagga tcctgtgcct gatctggccg cctgggtcac     3360

aagcttcgcc gctagaagat acggcgtgtc ccaccctgat gctggcgccg cttggagact     3420

gctgctgaga agcgtgtaca actgctccgg cgaggcctgc aggggccaca acagatctcc     3480

actcgtgcgg aggcccagcc tgcagatgaa caccagcatc tggtacaatc ggagcgacgt     3540

gttcgaggcc tggcgcctgc tgctgacatc tgctcctagc ctggccacct cccccgcctt     3600

cagatacgat ctgctggacc tgaccaggca ggccgtgcag gaactggtgt ccctgtacta     3660

cgaggaagcc agaagcgcct acctgagcaa agagctggcc tccctgctga gagcaggggg     3720

agtgctggct tacgaactgc tgccagccct ggatgaggtg ctggctagcg actccagatt     3780

tctgctgggc tcctggctgg aacaggccag agctgccgca gtgtctgagg ccgaggccga     3840

tttctacgag cagaacagca gataccagct gaccctgtgg ggcccagagg gcaacatcct     3900

ggactacgcc aacaaacagc tggccggcct ggtggccaac tactacacac ctagatggcg     3960

gctgtttctg gaagctctgg tggactctgt ggcccagggc atcccattcc agcagcacca     4020

gttcgacaag aacgtgttcc agctggaaca ggctttcgtg ctgagcaagc agagataccc     4080

cagccagcct agaggcgaca cagtggacct ggccaagaag atctttctga agtactaccc     4140

cagatgggtg gccggctctt ggtgagaatt cgagctcggt acccgggaat caattcactc     4200

ctcaggtgca ggctgcctat cagaaggtgg tggctggtgt ggccaatgcc ctggctcaca     4260

aataccactg agatcttttt ccctctgcca aaaattatgg ggacatcatg aagccccttg     4320

agcatctgac ttctggctaa taaaggaaat ttattttcat tgcaatagtg tgttggaatt     4380

ttttgtgtct ctcactcgga aggacatatg ggagggcaaa tcatttaaaa catcagaatg     4440

agtatttggt ttagagtttg gcaacatatg cccatatgct ggctgccatg aacaaaggtt     4500

ggctataaag aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata     4560

gaaaagcctt gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt     4620

taacatccct aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac     4680

tactcccagt catagctgtc cctcttctct tatggagatc cctcgacctg cagcccaagc     4740

tgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     4800

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggctt tgcccgggcg     4860

gcctcagtga gcgagcgagc gcgcag                                          4886


<210>  11
<211>  4891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-comNaGlu Nucleotide sequence

<400>  11
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgct agcgccacca tggaagctgc cggcctggcc gtgatcctgg gctttctgct     1980

gctggctggc ggctctgtgg gcgacgaggc cagagaagcc aaggctgtgc gcgagctggt     2040

cgtgcgcctg ctgggacctg gccctgccgc caacttcctg gtgtccgtgg aaagagccct     2100

ggccgacgag agcggcctgg acacatacag cctgtctggc ggcggaggcg tgccagttct     2160

ggtgcgcgga tctacaggcg tggccgctgc cgctggcctg cacagatacc tgagagactt     2220

ctgcggctgc caggtggcct ggtccagcgc tcagctgcat ctgccttggc ccctgcctgc     2280

cgtgcctgac ggcctgaccg agacaacccc caacagatac cggtactacc agaacgtgtg     2340

cacccacagc tacagcttcg tctggtggga ctgggccaga tgggagcaag aaatcgactg     2400

gatggccctg aacggcatca acctggctct ggcctggaac ggccaagaag ccatctggca     2460

gagagtgtat ctggccctgg gcctgaccca gagcgagatc gacacctact tcaccggccc     2520

tgcctttctg gcttggggca gaatgggcaa cctgcacacc tgggacggcc ccctgcccag     2580

aagctggcac ctgagccagg tgtacctgca gcacagaatc ctggacagaa tgagaagctt     2640

cggcatgatc cccgtgctgc ccgccttcgc tggccacgtg cccaaggcca tcaccagagt     2700

gttcccccaa gtgaacgtga tcaagctggg cagctggggc cacttcaact gcagctactc     2760

ctgcagcttc ctgctggccc ctggcgaccc catgttcccc ctgatcggca acctgttcct     2820

gagagagctg accaaagagt tcggcaccga ccacatctac ggcgccgaca ccttcaacga     2880

gatgcagccc cccttcagcg acccctctta cctggccgcc accacagccg ccgtgtacga     2940

ggccatggtg acagtggacc ccgacgccgt gtggctgctg cagggctggc tgttccagca     3000

ccagccccag ttctggggac ctagccagat cagagccgtg ctggaagccg tgcccagagg     3060

cagactgctg gtgctggacc tgttcgccga gagccacccc gtgtacatgc acaccgccag     3120

cttccacggc cagcccttca tctggtgcat gctgcacaac ttcggcggca accacggcct     3180

gttcggcgcc ctggaagatg tgaacagagg cccccaggcc gccagactgt tccccaacag     3240

caccatggtc ggaaccggaa tcgcccccga gggcatcggc cagaacgagg tggtgtacgc     3300

cctgatggcc gagctgggct ggcggaagga ccctgtgcct gacctgatgg cctgggtgtc     3360

cagcttcgcc atcagacgct acggcgtgtc ccagcctgat gccgtggccg cttggaagct     3420

gctgctgaga agcgtgtaca actgcagcgg cgaggcctgc agcggccaca acagatcccc     3480

cctggtgaaa agacccagcc tgcagatgag caccgccgtg tggtacaacc gcagcgacgt     3540

gttcgaggcc tggcgcctgc tgctgacagc cgcccctaac ctgaccacct cccccgcctt     3600

cagatacgac ctgctggacg tgaccagaca ggccgtgcaa gaactggtgt ccctgtgcta     3660

cgaggaagcc agaaccgcct acctgaaaca agaactggac ctgctcctgc gggcaggcgg     3720

cctgctggtg tacaagctgc tgcccaccct ggacgagctg ctggccagct ctagccactt     3780

tctgctgggc acatggctgg accaggccag aaaggccgct gtgtctgagg ccgaggccca     3840

gttctacgag cagaacagca gataccagat caccctgtgg ggccctgagg gcaacatcct     3900

ggactacgcc aacaagcagc tggctggcct ggtggccgac tactaccagc ccagatggtg     3960

cctgttcctg ggcaccctgg cccacagcct ggctagaggc gtgcccttcc agcagcacga     4020

gttcgagaag aacgtgttcc ctctggaaca ggccttcgtg tacaacaaga agagataccc     4080

cagccagccc agaggcgaca ccgtggacct gagcaagaag atcttcctga agtaccaccc     4140

ccagcccgac agcctgtgat gagcggccgc gaattcgagc tcggtacccg ggaatcaatt     4200

cactcctcag gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca atgccctggc     4260

tcacaaatac cactgagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc     4320

ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     4380

gaattttttg tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca     4440

gaatgagtat ttggtttaga gtttggcaac atatgcccat atgctggctg ccatgaacaa     4500

aggttggcta taaagaggtc atcagtatat gaaacagccc cctgctgtcc attccttatt     4560

ccatagaaaa gccttgactt gaggttagat tttttttata ttttgttttg tgttattttt     4620

ttctttaaca tccctaaaat tttccttaca tgttttacta gccagatttt tcctcctctc     4680

ctgactactc ccagtcatag ctgtccctct tctcttatgg agatccctcg acctgcagcc     4740

caagctgtag ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg     4800

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggctttgccc     4860

gggcggcctc agtgagcgag cgagcgcgca g                                    4891


<210>  12
<211>  4898
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-cocNaGlu Nucleotide sequence

<400>  12
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgggag ctgccgctgc tgctgctgtc ctgggcctcc tgctcctggg     1980

agctgctggc ggagccgccg ctgatgaagc cagagaagcc gctgccgtgc gggctctgct     2040

cgtcagactg ctgggacctg gacccgcagc tgccttcagc gtgtccgtga aaagagccct     2100

ggccgccgag agcggcctgg acacctatag actgtctggc ggcggagccg gcaccagggt     2160

gctggtgctg ggatctacag gtgtcgccgc tgccgccgga ctgcacagat acctgaggga     2220

cttctgcggc tgccatgtgg cttggagcgg cagccagctg agactgcctg agcctctgcc     2280

tgccgtgcct caggtgctga ccgaggccac ccccaacaga taccggtact accagaacgt     2340

gtgcacccac agctacagct tcgtctggtg ggactgggcc agatgggagc gcgagctgga     2400

ctggatggcc ctgaacggca tcaacctggc tctcgcttgg agtggccagg aagccatctg     2460

gcagagggtg tacctggccc tgggcctgac ccagagcgag atcgacgagt acttcaccgg     2520

ccctgccttt ctggcctggg gcaggatggg caacctgcac acctggggcg gacccctgcc     2580

tcacagctgg cacctgaagc agctgtacct gcagcacagg atcctggaca ggatgcggag     2640

cttcggcatg atccccgtgc tgcccgcctt cagcggccac gtgccaaagg ccctgaccag     2700

ggtgttcccc cagatcaaca tcacacagct cggaagttgg ggccacttca actgcagcta     2760

ctcctgcagc ttcctgctgg cccccgagga ccccctgttc cctatcatcg gcagcctgtt     2820

tctgagagag ctgatccagg aatttggcac caaccacatc tacggcgccg acaccttcaa     2880

cgagatgcag ccccccagca gcgagcccag ctacctggcc tctgccaccg ccagcgtgta     2940

ccaggccatg atcaccgtgg acagcgacgc cgtgtggctg ctgcagggct ggctgttcca     3000

gcaccagcct cagttctggg gccctgccca ggtcaaagcc gtgctggaag ccgtgcccag     3060

gggcaggctg ctcgtgctgg atctgttcgc cgagagccag cccgtgtaca tccagaccgc     3120

cagcttccag ggccagccct tcatctggtg catgctgcac aacttcggcg gcaaccacgg     3180

cctgttcgga gccctcgagg ccgtgaatag aggcccagcc gccgctaggc tgttccccaa     3240

ctctaccatg ctgggcaccg gaatggcccc tgagggcatc ggccagaacg aggtggtgta     3300

cgccctgatg gccgagctgg gctggcggaa ggatcccgtg gccgatctgg aagcctgggt     3360

gtccagcttc gccgctcgga gatacggcgt ggcccacaga gataccgaag ccgcctggag     3420

actgctgctg agaagcgtgt acaactgcag cggcgaggcc tgctccggcc acaacagatc     3480

tccactcgtg cggaggccct ccctgcagat ggtcaccacc gtgtggtata accgcagcga     3540

cgtgttcgag gcttggagac tgctgctgac cgccgctcct accctggcca gcagccccac     3600

cttcagatac gacctgctgg acgtgaccag gcaggccgcc caggaactcg tcagcctgta     3660

ctacgtggaa gccagaagcg cctacctgcg gaaagaactg gtgcccctgc tgagggccgc     3720

tggcgtgctg gtgtatgagc tgctgcctgc cctggacaag gtgctggcta gcgactcccg     3780

gttcctgctg ggcagatggc tggaacaggc cagggctgcc gccgtgtctg aagccgaggc     3840

ccacctgtac gagcagaaca gcagatacca gctgaccctg tggggacccg agggcaacat     3900

cctggactac gccaacaagc agctggccgg cctggtggcc gactactaca cccccagatg     3960

gcggctgttc atggaaatgc tggtggaaag cctggtgcag ggcatcccat tccagcagca     4020

ccagttcgac aagaacgcct tccagctcga gcagaccttc atcttcggca cccagagata     4080

ccccagccag cccgacggcg acaccgtgga cctggccaag aagctgttca tcaagtacta     4140

ccccaggctg gtggccggct ccctgtgggc cgattgagaa ttcgagctcg gtacccggga     4200

atcaattcac tcctcaggtg caggctgcct atcagaaggt ggtggctggt gtggccaatg     4260

ccctggctca caaataccac tgagatcttt ttccctctgc caaaaattat ggggacatca     4320

tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag     4380

tgtgttggaa ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttaa     4440

aacatcagaa tgagtatttg gtttagagtt tggcaacata tgcccatatg ctggctgcca     4500

tgaacaaagg ttggctataa agaggtcatc agtatatgaa acagccccct gctgtccatt     4560

ccttattcca tagaaaagcc ttgacttgag gttagatttt ttttatattt tgttttgtgt     4620

tatttttttc tttaacatcc ctaaaatttt ccttacatgt tttactagcc agatttttcc     4680

tcctctcctg actactccca gtcatagctg tccctcttct cttatggaga tccctcgacc     4740

tgcagcccaa gctgtagata agtagcatgg cgggttaatc attaactaca aggaacccct     4800

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc     4860

tttgcccggg cggcctcagt gagcgagcga gcgcgcag                             4898


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for genotyping

<400>  13
gtcgtctcct ggttctggac                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for genotyping

<400>  14
accacttcat tctggccaat                                                   20


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer mutation for genotyping

<400>  15
cgctttctgg gctcagag                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for quantification

<400>  16
gccgaggccc agttctac                                                     18


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for quantification

<400>  17
ttggcgtagt ccaggatgtt g                                                 21


<210>  18
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe for quantification

<400>  18
agcagaacag cagataccag atcaccc                                           27


<210>  19
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cohNaglu-version2 CDS sequence

<400>  19
cgcgtgccac catggaagca gtcgccgtcg ccgcagcagt gggtgtcctc ctcctcgccg       60

gtgctggagg tgccgccggg gacgaggccc gcgaggccgc agctgtgcgg gcccttgtgg      120

cccggcttct cggaccgggc cctgccgccg acttcagcgt gtcagtggaa cgcgcactgg      180

ctgcgaagcc tgggctcgat acttactccc tgggcggggg tggtgccgcc agagtgcggg      240

tccggggaag caccggggtg gccgccgcgg ccggcctgca ccggtacctt cgggactttt      300

gcggctgtca tgtcgcttgg tccggatccc agctgcgcct cccccgaccg ctgcccgccg      360

tgcctggaga gctgaccgag gccactccga accggtacag atactatcag aacgtgtgca      420

ctcagtccta ctccttcgtg tggtgggact gggccagatg ggagcgggag attgactgga      480

tggccctgaa cggtatcaac ctcgccttgg cctggtccgg ccaggaggcc atttggcaga      540

gggtgtacct tgcactggga ctgactcaag ccgagatcaa cgagtttttc accggccccg      600

ctttccttgc ctgggggcgc atgggcaacc tccacacctg ggacgggcct ctgccgccct      660

cctggcatat caagcagctg tacctccagc acagggtgct tgaccagatg cggagctttg      720

gaatgacccc tgtgctgccc gcgttcgcgg gtcacgtgcc agaagcagtg actcgcgtgt      780

tcccccaagt gaacgtcacc aaaatgggat cgtggggaca ctttaactgc tcttattcct      840

gctccttcct cttggcgccg gaggacccga tcttcccgat tattggatcg ctgttcctgc      900

gggagctgat caaggagttc ggaaccgacc acatctacgg cgctgacacc ttcaacgaga      960

tgcagccgcc ttcctccgaa ccatcgtacc tcgcggccgc tactactgcg gtgtacgagg     1020

ccatgaccgc agtggatacc gaagccgtct ggctgctgca agggtggttg ttccagcacc     1080

agccgcagtt ttggggaccc gcccagattc gcgccgtgct gggcgccgtg cctaggggtc     1140

gcctgctcgt gctggacctg ttcgccgagt cccagccagt gtacactagg accgcgtcgt     1200

tccaaggaca gcccttcatt tggtgtatgc ttcacaactt cgggggcaac cacggtctgt     1260

tcggagcctt ggaagccgtg aatggcggtc ccgaggcagc gcggcttttc cccaactcaa     1320

ccatggtcgg aaccggaatg gcccctgaag gaatctccca gaacgaagtc gtgtactcgc     1380

tgatggcaga gctgggctgg cggaaggatc ctgtccctga tctcgccgcc tgggtgacat     1440

ccttcgccgc tcgccgctat ggtgtctccc atccggatgc cggagccgca tggaggctgc     1500

tgctgagatc cgtgtacaac tgctcgggag aagcgtgtcg gggacataac aggtccccac     1560

tcgtgcgcag accgagcctg cagatgaaca cctccatctg gtacaaccgg tccgacgtgt     1620

tcgaagcgtg gagactgctg ctgacttccg ccccgagcct cgcgaccagc ccggcgttcc     1680

gctacgatct cctggacctc acaagacagg cggtccaaga actggtgtcc ctgtactacg     1740

aagaggcccg ctccgcatac ctcagcaagg aactcgcatc gttgctgagg gccggcggag     1800

tgctggcata cgagctgctg ccggccctgg acgaagtgct ggccagcgac agccggttcc     1860

tgctgggctc ttggctggaa caggcccgcg ctgctgcggt gtccgaagcc gaagcggact     1920

tctacgagca gaactcacgg taccaactga ccctctgggg tccggagggc aacattctgg     1980

actacgccaa caagcaactc gccggcctgg tcgcaaatta ctatactcct cggtggaggc     2040

tgttcctgga agcgctggtc gattcagtgg ctcaggggat cccattccaa cagcaccaat     2100

tcgacaagaa cgtgttccag cttgagcagg cctttgtgtt gtcgaagcag cgctacccca     2160

gccagccacg gggagacacg gtggacctgg ccaagaagat cttcctgaaa tactacccaa     2220

gatgggtggc cggctcgtgg tagg                                            2244


<210>  20
<211>  8467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-cohNaglu-version2 sequence

<400>  20
gggcgatcgg tgcgggcctc ttcgctatta cgccagctgc gcgctcgctc gctcactgag       60

gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag      120

cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt      180

aacccgccat gctacttatc tactcgacat tgattattga ctagttatta atagtaatca      240

attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta      300

aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat      360

gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg      420

taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac      480

gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt      540

cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga ggtgagcccc      600

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt      660

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg cgcgccaggc      720

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      780

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      840

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttgattaatt cgagcgaacg cgtgccacca tggaagcagt cgccgtcgcc     1980

gcagcagtgg gtgtcctcct cctcgccggt gctggaggtg ccgccgggga cgaggcccgc     2040

gaggccgcag ctgtgcgggc ccttgtggcc cggcttctcg gaccgggccc tgccgccgac     2100

ttcagcgtgt cagtggaacg cgcactggct gcgaagcctg ggctcgatac ttactccctg     2160

ggcgggggtg gtgccgccag agtgcgggtc cggggaagca ccggggtggc cgccgcggcc     2220

ggcctgcacc ggtaccttcg ggacttttgc ggctgtcatg tcgcttggtc cggatcccag     2280

ctgcgcctcc cccgaccgct gcccgccgtg cctggagagc tgaccgaggc cactccgaac     2340

cggtacagat actatcagaa cgtgtgcact cagtcctact ccttcgtgtg gtgggactgg     2400

gccagatggg agcgggagat tgactggatg gccctgaacg gtatcaacct cgccttggcc     2460

tggtccggcc aggaggccat ttggcagagg gtgtaccttg cactgggact gactcaagcc     2520

gagatcaacg agtttttcac cggccccgct ttccttgcct gggggcgcat gggcaacctc     2580

cacacctggg acgggcctct gccgccctcc tggcatatca agcagctgta cctccagcac     2640

agggtgcttg accagatgcg gagctttgga atgacccctg tgctgcccgc gttcgcgggt     2700

cacgtgccag aagcagtgac tcgcgtgttc ccccaagtga acgtcaccaa aatgggatcg     2760

tggggacact ttaactgctc ttattcctgc tccttcctct tggcgccgga ggacccgatc     2820

ttcccgatta ttggatcgct gttcctgcgg gagctgatca aggagttcgg aaccgaccac     2880

atctacggcg ctgacacctt caacgagatg cagccgcctt cctccgaacc atcgtacctc     2940

gcggccgcta ctactgcggt gtacgaggcc atgaccgcag tggataccga agccgtctgg     3000

ctgctgcaag ggtggttgtt ccagcaccag ccgcagtttt ggggacccgc ccagattcgc     3060

gccgtgctgg gcgccgtgcc taggggtcgc ctgctcgtgc tggacctgtt cgccgagtcc     3120

cagccagtgt acactaggac cgcgtcgttc caaggacagc ccttcatttg gtgtatgctt     3180

cacaacttcg ggggcaacca cggtctgttc ggagccttgg aagccgtgaa tggcggtccc     3240

gaggcagcgc ggcttttccc caactcaacc atggtcggaa ccggaatggc ccctgaagga     3300

atctcccaga acgaagtcgt gtactcgctg atggcagagc tgggctggcg gaaggatcct     3360

gtccctgatc tcgccgcctg ggtgacatcc ttcgccgctc gccgctatgg tgtctcccat     3420

ccggatgccg gagccgcatg gaggctgctg ctgagatccg tgtacaactg ctcgggagaa     3480

gcgtgtcggg gacataacag gtccccactc gtgcgcagac cgagcctgca gatgaacacc     3540

tccatctggt acaaccggtc cgacgtgttc gaagcgtgga gactgctgct gacttccgcc     3600

ccgagcctcg cgaccagccc ggcgttccgc tacgatctcc tggacctcac aagacaggcg     3660

gtccaagaac tggtgtccct gtactacgaa gaggcccgct ccgcatacct cagcaaggaa     3720

ctcgcatcgt tgctgagggc cggcggagtg ctggcatacg agctgctgcc ggccctggac     3780

gaagtgctgg ccagcgacag ccggttcctg ctgggctctt ggctggaaca ggcccgcgct     3840

gctgcggtgt ccgaagccga agcggacttc tacgagcaga actcacggta ccaactgacc     3900

ctctggggtc cggagggcaa cattctggac tacgccaaca agcaactcgc cggcctggtc     3960

gcaaattact atactcctcg gtggaggctg ttcctggaag cgctggtcga ttcagtggct     4020

caggggatcc cattccaaca gcaccaattc gacaagaacg tgttccagct tgagcaggcc     4080

tttgtgttgt cgaagcagcg ctaccccagc cagccacggg gagacacggt ggacctggcc     4140

aagaagatct tcctgaaata ctacccaaga tgggtggccg gctcgtggta ggaattcgag     4200

ctcggtaccc gggaatcaat tcactcctca ggtgcaggct gcctatcaga aggtggtggc     4260

tggtgtggcc aatgccctgg ctcacaaata ccactgagat ctttttccct ctgccaaaaa     4320

ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat     4380

tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagga catatgggag     4440

ggcaaatcat ttaaaacatc agaatgagta tttggtttag agtttggcaa catatgccca     4500

tatgctggct gccatgaaca aaggttggct ataaagaggt catcagtata tgaaacagcc     4560

ccctgctgtc cattccttat tccatagaaa agccttgact tgaggttaga ttttttttat     4620

attttgtttt gtgttatttt tttctttaac atccctaaaa ttttccttac atgttttact     4680

agccagattt ttcctcctct cctgactact cccagtcata gctgtccctc ttctcttatg     4740

gagatccctc gacctgcagc ccaagctgta gataagtagc atggcgggtt aatcattaac     4800

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4860

gaggccgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcatta     4920

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc     4980

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     5040

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     5100

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     5160

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     5220

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     5280

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     5340

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     5400

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     5460

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     5520

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     5580

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     5640

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     5700

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     5760

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     5820

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     5880

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     5940

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     6000

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     6060

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     6120

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     6180

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     6240

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     6300

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     6360

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     6420

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     6480

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     6540

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     6600

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     6660

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     6720

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     6780

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     6840

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     6900

cgtctaagaa accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc     6960

ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga     7020

gacggtcaca gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc     7080

agcgggtgtt ggcgggtgtc ggggctggct taactatgcg gcatcagagc agattgtact     7140

gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat     7200

caggcgattc caacatccaa taaatcatac aggcaaggca aagaattagc aaaattaagc     7260

aataaagcct cagagcataa agctaaatcg gttgtaccaa aaacattatg accctgtaat     7320

acttttgcgg gagaagcctt tatttcaacg caaggataaa aatttttaga accctcatat     7380

attttaaatg caatgcctga gtaatgtgta ggtaaagatt caaacgggtg agaaaggccg     7440

gagacagtca aatcaccatc aatatgatat tcaaccgttc tagctgataa attcatgccg     7500

gagagggtag ctatttttga gaggtctcta caaaggctat caggtcattg cctgagagtc     7560

tggagcaaac aagagaatcg atgaacggta atcgtaaaac tagcatgtca atcatatgta     7620

ccccggttga taatcagaaa agccccaaaa acaggaagat tgtataagca aatatttaaa     7680

ttgtaagcgt taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt     7740

ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag     7800

ggttgagtgt tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg     7860

tcaaagggcg aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat     7920

caagtttttt ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc     7980

gatttagagc ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga     8040

aaggagcggg cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac     8100

ccgccgcgct taatgcgccg ctacagggcg cgtactatgg ttgctttgac gagcacgtat     8160

aacgtgcttt cctcgttaga atcagagcgg gagctaaaca ggaggccgat taaagggatt     8220

ttagacagga acggtacgcc agaatcctga gaagtgtttt tataatcagt gaggccaccg     8280

agtaaaagag tctgtccatc acgcaaatta accgttgtcg caatacttct ttgattagta     8340

ataacatcac ttgcctgagt agaagaactc aaactatcgg ccttgctggt aatatccaga     8400

acaatattac cgccagccat tgcaacggaa tcgccattcg ccattcaggc tgcgcaactg     8460

ttgggaa                                                               8467


<210>  21
<211>  4886
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-cohNaglu-version2 sequence

<400>  21
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatggaag cagtcgccgt cgccgcagca gtgggtgtcc tcctcctcgc     1980

cggtgctgga ggtgccgccg gggacgaggc ccgcgaggcc gcagctgtgc gggcccttgt     2040

ggcccggctt ctcggaccgg gccctgccgc cgacttcagc gtgtcagtgg aacgcgcact     2100

ggctgcgaag cctgggctcg atacttactc cctgggcggg ggtggtgccg ccagagtgcg     2160

ggtccgggga agcaccgggg tggccgccgc ggccggcctg caccggtacc ttcgggactt     2220

ttgcggctgt catgtcgctt ggtccggatc ccagctgcgc ctcccccgac cgctgcccgc     2280

cgtgcctgga gagctgaccg aggccactcc gaaccggtac agatactatc agaacgtgtg     2340

cactcagtcc tactccttcg tgtggtggga ctgggccaga tgggagcggg agattgactg     2400

gatggccctg aacggtatca acctcgcctt ggcctggtcc ggccaggagg ccatttggca     2460

gagggtgtac cttgcactgg gactgactca agccgagatc aacgagtttt tcaccggccc     2520

cgctttcctt gcctgggggc gcatgggcaa cctccacacc tgggacgggc ctctgccgcc     2580

ctcctggcat atcaagcagc tgtacctcca gcacagggtg cttgaccaga tgcggagctt     2640

tggaatgacc cctgtgctgc ccgcgttcgc gggtcacgtg ccagaagcag tgactcgcgt     2700

gttcccccaa gtgaacgtca ccaaaatggg atcgtgggga cactttaact gctcttattc     2760

ctgctccttc ctcttggcgc cggaggaccc gatcttcccg attattggat cgctgttcct     2820

gcgggagctg atcaaggagt tcggaaccga ccacatctac ggcgctgaca ccttcaacga     2880

gatgcagccg ccttcctccg aaccatcgta cctcgcggcc gctactactg cggtgtacga     2940

ggccatgacc gcagtggata ccgaagccgt ctggctgctg caagggtggt tgttccagca     3000

ccagccgcag ttttggggac ccgcccagat tcgcgccgtg ctgggcgccg tgcctagggg     3060

tcgcctgctc gtgctggacc tgttcgccga gtcccagcca gtgtacacta ggaccgcgtc     3120

gttccaagga cagcccttca tttggtgtat gcttcacaac ttcgggggca accacggtct     3180

gttcggagcc ttggaagccg tgaatggcgg tcccgaggca gcgcggcttt tccccaactc     3240

aaccatggtc ggaaccggaa tggcccctga aggaatctcc cagaacgaag tcgtgtactc     3300

gctgatggca gagctgggct ggcggaagga tcctgtccct gatctcgccg cctgggtgac     3360

atccttcgcc gctcgccgct atggtgtctc ccatccggat gccggagccg catggaggct     3420

gctgctgaga tccgtgtaca actgctcggg agaagcgtgt cggggacata acaggtcccc     3480

actcgtgcgc agaccgagcc tgcagatgaa cacctccatc tggtacaacc ggtccgacgt     3540

gttcgaagcg tggagactgc tgctgacttc cgccccgagc ctcgcgacca gcccggcgtt     3600

ccgctacgat ctcctggacc tcacaagaca ggcggtccaa gaactggtgt ccctgtacta     3660

cgaagaggcc cgctccgcat acctcagcaa ggaactcgca tcgttgctga gggccggcgg     3720

agtgctggca tacgagctgc tgccggccct ggacgaagtg ctggccagcg acagccggtt     3780

cctgctgggc tcttggctgg aacaggcccg cgctgctgcg gtgtccgaag ccgaagcgga     3840

cttctacgag cagaactcac ggtaccaact gaccctctgg ggtccggagg gcaacattct     3900

ggactacgcc aacaagcaac tcgccggcct ggtcgcaaat tactatactc ctcggtggag     3960

gctgttcctg gaagcgctgg tcgattcagt ggctcagggg atcccattcc aacagcacca     4020

attcgacaag aacgtgttcc agcttgagca ggcctttgtg ttgtcgaagc agcgctaccc     4080

cagccagcca cggggagaca cggtggacct ggccaagaag atcttcctga aatactaccc     4140

aagatgggtg gccggctcgt ggtaggaatt cgagctcggt acccgggaat caattcactc     4200

ctcaggtgca ggctgcctat cagaaggtgg tggctggtgt ggccaatgcc ctggctcaca     4260

aataccactg agatcttttt ccctctgcca aaaattatgg ggacatcatg aagccccttg     4320

agcatctgac ttctggctaa taaaggaaat ttattttcat tgcaatagtg tgttggaatt     4380

ttttgtgtct ctcactcgga aggacatatg ggagggcaaa tcatttaaaa catcagaatg     4440

agtatttggt ttagagtttg gcaacatatg cccatatgct ggctgccatg aacaaaggtt     4500

ggctataaag aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata     4560

gaaaagcctt gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt     4620

taacatccct aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac     4680

tactcccagt catagctgtc cctcttctct tatggagatc cctcgacctg cagcccaagc     4740

tgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     4800

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggctt tgcccgggcg     4860

gcctcagtga gcgagcgagc gcgcag                                          4886


<210>  22
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cohNaglu-version3 CDS sequence

<400>  22
cgcgtgccac catggaggct gtcgccgtcg ccgccgctgt cggagtgctg ctgctggctg       60

gggctggagg ggctgctgga gatgaggcta gggaagctgc agctgtgcgc gcactggtcg      120

cacgactgct gggacctggg ccagcagccg acttctctgt gagtgtcgag cgagcactgg      180

ctgcaaagcc tggcctggat acctacagtc tgggaggagg aggagcagct cgagtgaggg      240

tcagagggtc aacaggagtg gcagcagctg caggactgca ccgatatctg cgagactttt      300

gcggctgtca tgtggcctgg tcaggaagcc agctgaggct gcccagacct ctgccagcag      360

tgccaggcga gctgacagaa gccactccca accggtaccg ctactatcag aatgtgtgca      420

cccagtccta ttctttcgtc tggtgggact gggctcgatg ggagcgcgaa atcgattgga      480

tggcactgaa cggaattaat ctggcactgg catggagcgg acaggaggca atctggcaga      540

gagtgtacct ggcactggga ctgactcagg ccgagattaa cgagttcttc accgggccag      600

cttttctggc atggggacgg atggggaatc tgcacacatg ggacggacca ctgccacctt      660

cttggcacat caagcagctg tatctgcagc atagggtgct ggatcagatg agaagttttg      720

gcatgactcc agtgctgccc gctttcgcag gacacgtccc tgaggccgtg accagggtgt      780

tcccacaggt gaacgtcact aagatgggca gctggggaca ttttaattgc agttactcat      840

gtagcttcct gctggcccct gaagacccaa tttttcccat cattggcagc ctgttcctgc      900

gggagctgat caaagaattt ggaaccgacc acatctacgg ggccgataca ttcaacgaga      960

tgcagccacc cagctccgaa ccttcctacc tggccgctgc aaccacagca gtgtatgagg     1020

ccatgaccgc tgtggacaca gaagccgtct ggctgctgca ggggtggctg tttcagcatc     1080

agccacagtt ctggggacct gcacagatcc gagctgtgct gggagcagtc ccacgaggaa     1140

ggctgctggt gctggatctg tttgccgagt cccagcccgt ctacactagg accgcttctt     1200

tccagggcca gccttttatt tggtgtatgc tgcacaactt tggagggaat catgggctgt     1260

tcggagcact ggaggcagtg aacggaggac cagaagcagc tagactgttt cctaattcta     1320

ctatggtggg caccggaatg gctcccgagg gcatctcaca gaatgaagtg gtctacagcc     1380

tgatggcaga gctgggatgg cgaaaggacc cagtgcctga tctggcagcc tgggtcacta     1440

gtttcgctgc aaggagatac ggggtgtcac accctgacgc tggagcagct tggcgactgc     1500

tgctgaggtc tgtgtataac tgcagtgggg aggcctgtag aggccataat cgatccccac     1560

tggtgcggcg accatcactg cagatgaaca ccagcatttg gtacaatcga tccgatgtgt     1620

ttgaagcttg gaggctgctg ctgacaagtg ccccttcact ggctacttct ccagcattca     1680

gatatgacct gctggatctg acacggcagg cagtgcagga gctggtcagc ctgtactatg     1740

aggaagctcg cagcgcatac ctgtccaaag aactggcatc cctgctgagg gcaggaggag     1800

tgctggctta tgagctgctg ccagctctgg acgaagtcct ggcatccgat tctcgctttc     1860

tgctgggaag ctggctggag caggcccgag cagccgctgt gtccgaggcc gaagctgact     1920

tctacgagca gaactctagg tatcagctga ctctgtgggg acccgaaggg aacatcctgg     1980

attacgccaa taagcagctg gccggactgg tggctaatta ctatacccct agatggcggc     2040

tgttcctgga ggcactggtg gacagcgtcg ctcaggggat tccattccag cagcaccagt     2100

ttgataagaa cgtgttccag ctggaacagg cctttgtcct gtctaaacag cggtacccta     2160

gtcagccacg cggggacaca gtggatctgg ctaagaaaat cttcctgaaa tactatccta     2220

gatgggtcgc cggcagctgg tgag                                            2244


<210>  23
<211>  8467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-cohNaglu-version3 sequence

<400>  23
gggcgatcgg tgcgggcctc ttcgctatta cgccagctgc gcgctcgctc gctcactgag       60

gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag      120

cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt      180

aacccgccat gctacttatc tactcgacat tgattattga ctagttatta atagtaatca      240

attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta      300

aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat      360

gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg      420

taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac      480

gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt      540

cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga ggtgagcccc      600

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt      660

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg cgcgccaggc      720

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      780

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      840

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttgattaatt cgagcgaacg cgtgccacca tggaggctgt cgccgtcgcc     1980

gccgctgtcg gagtgctgct gctggctggg gctggagggg ctgctggaga tgaggctagg     2040

gaagctgcag ctgtgcgcgc actggtcgca cgactgctgg gacctgggcc agcagccgac     2100

ttctctgtga gtgtcgagcg agcactggct gcaaagcctg gcctggatac ctacagtctg     2160

ggaggaggag gagcagctcg agtgagggtc agagggtcaa caggagtggc agcagctgca     2220

ggactgcacc gatatctgcg agacttttgc ggctgtcatg tggcctggtc aggaagccag     2280

ctgaggctgc ccagacctct gccagcagtg ccaggcgagc tgacagaagc cactcccaac     2340

cggtaccgct actatcagaa tgtgtgcacc cagtcctatt ctttcgtctg gtgggactgg     2400

gctcgatggg agcgcgaaat cgattggatg gcactgaacg gaattaatct ggcactggca     2460

tggagcggac aggaggcaat ctggcagaga gtgtacctgg cactgggact gactcaggcc     2520

gagattaacg agttcttcac cgggccagct tttctggcat ggggacggat ggggaatctg     2580

cacacatggg acggaccact gccaccttct tggcacatca agcagctgta tctgcagcat     2640

agggtgctgg atcagatgag aagttttggc atgactccag tgctgcccgc tttcgcagga     2700

cacgtccctg aggccgtgac cagggtgttc ccacaggtga acgtcactaa gatgggcagc     2760

tggggacatt ttaattgcag ttactcatgt agcttcctgc tggcccctga agacccaatt     2820

tttcccatca ttggcagcct gttcctgcgg gagctgatca aagaatttgg aaccgaccac     2880

atctacgggg ccgatacatt caacgagatg cagccaccca gctccgaacc ttcctacctg     2940

gccgctgcaa ccacagcagt gtatgaggcc atgaccgctg tggacacaga agccgtctgg     3000

ctgctgcagg ggtggctgtt tcagcatcag ccacagttct ggggacctgc acagatccga     3060

gctgtgctgg gagcagtccc acgaggaagg ctgctggtgc tggatctgtt tgccgagtcc     3120

cagcccgtct acactaggac cgcttctttc cagggccagc cttttatttg gtgtatgctg     3180

cacaactttg gagggaatca tgggctgttc ggagcactgg aggcagtgaa cggaggacca     3240

gaagcagcta gactgtttcc taattctact atggtgggca ccggaatggc tcccgagggc     3300

atctcacaga atgaagtggt ctacagcctg atggcagagc tgggatggcg aaaggaccca     3360

gtgcctgatc tggcagcctg ggtcactagt ttcgctgcaa ggagatacgg ggtgtcacac     3420

cctgacgctg gagcagcttg gcgactgctg ctgaggtctg tgtataactg cagtggggag     3480

gcctgtagag gccataatcg atccccactg gtgcggcgac catcactgca gatgaacacc     3540

agcatttggt acaatcgatc cgatgtgttt gaagcttgga ggctgctgct gacaagtgcc     3600

ccttcactgg ctacttctcc agcattcaga tatgacctgc tggatctgac acggcaggca     3660

gtgcaggagc tggtcagcct gtactatgag gaagctcgca gcgcatacct gtccaaagaa     3720

ctggcatccc tgctgagggc aggaggagtg ctggcttatg agctgctgcc agctctggac     3780

gaagtcctgg catccgattc tcgctttctg ctgggaagct ggctggagca ggcccgagca     3840

gccgctgtgt ccgaggccga agctgacttc tacgagcaga actctaggta tcagctgact     3900

ctgtggggac ccgaagggaa catcctggat tacgccaata agcagctggc cggactggtg     3960

gctaattact atacccctag atggcggctg ttcctggagg cactggtgga cagcgtcgct     4020

caggggattc cattccagca gcaccagttt gataagaacg tgttccagct ggaacaggcc     4080

tttgtcctgt ctaaacagcg gtaccctagt cagccacgcg gggacacagt ggatctggct     4140

aagaaaatct tcctgaaata ctatcctaga tgggtcgccg gcagctggtg agaattcgag     4200

ctcggtaccc gggaatcaat tcactcctca ggtgcaggct gcctatcaga aggtggtggc     4260

tggtgtggcc aatgccctgg ctcacaaata ccactgagat ctttttccct ctgccaaaaa     4320

ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat     4380

tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagga catatgggag     4440

ggcaaatcat ttaaaacatc agaatgagta tttggtttag agtttggcaa catatgccca     4500

tatgctggct gccatgaaca aaggttggct ataaagaggt catcagtata tgaaacagcc     4560

ccctgctgtc cattccttat tccatagaaa agccttgact tgaggttaga ttttttttat     4620

attttgtttt gtgttatttt tttctttaac atccctaaaa ttttccttac atgttttact     4680

agccagattt ttcctcctct cctgactact cccagtcata gctgtccctc ttctcttatg     4740

gagatccctc gacctgcagc ccaagctgta gataagtagc atggcgggtt aatcattaac     4800

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4860

gaggccgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcatta     4920

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc     4980

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     5040

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     5100

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     5160

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     5220

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     5280

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     5340

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     5400

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     5460

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     5520

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     5580

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     5640

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     5700

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     5760

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     5820

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     5880

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     5940

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     6000

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     6060

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     6120

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     6180

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     6240

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     6300

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     6360

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     6420

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     6480

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     6540

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     6600

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     6660

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     6720

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     6780

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     6840

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     6900

cgtctaagaa accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc     6960

ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga     7020

gacggtcaca gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc     7080

agcgggtgtt ggcgggtgtc ggggctggct taactatgcg gcatcagagc agattgtact     7140

gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat     7200

caggcgattc caacatccaa taaatcatac aggcaaggca aagaattagc aaaattaagc     7260

aataaagcct cagagcataa agctaaatcg gttgtaccaa aaacattatg accctgtaat     7320

acttttgcgg gagaagcctt tatttcaacg caaggataaa aatttttaga accctcatat     7380

attttaaatg caatgcctga gtaatgtgta ggtaaagatt caaacgggtg agaaaggccg     7440

gagacagtca aatcaccatc aatatgatat tcaaccgttc tagctgataa attcatgccg     7500

gagagggtag ctatttttga gaggtctcta caaaggctat caggtcattg cctgagagtc     7560

tggagcaaac aagagaatcg atgaacggta atcgtaaaac tagcatgtca atcatatgta     7620

ccccggttga taatcagaaa agccccaaaa acaggaagat tgtataagca aatatttaaa     7680

ttgtaagcgt taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt     7740

ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag     7800

ggttgagtgt tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg     7860

tcaaagggcg aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat     7920

caagtttttt ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc     7980

gatttagagc ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga     8040

aaggagcggg cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac     8100

ccgccgcgct taatgcgccg ctacagggcg cgtactatgg ttgctttgac gagcacgtat     8160

aacgtgcttt cctcgttaga atcagagcgg gagctaaaca ggaggccgat taaagggatt     8220

ttagacagga acggtacgcc agaatcctga gaagtgtttt tataatcagt gaggccaccg     8280

agtaaaagag tctgtccatc acgcaaatta accgttgtcg caatacttct ttgattagta     8340

ataacatcac ttgcctgagt agaagaactc aaactatcgg ccttgctggt aatatccaga     8400

acaatattac cgccagccat tgcaacggaa tcgccattcg ccattcaggc tgcgcaactg     8460

ttgggaa                                                               8467


<210>  24
<211>  4886
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-cohNaglu-version3 sequence

<400>  24
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatggagg ctgtcgccgt cgccgccgct gtcggagtgc tgctgctggc     1980

tggggctgga ggggctgctg gagatgaggc tagggaagct gcagctgtgc gcgcactggt     2040

cgcacgactg ctgggacctg ggccagcagc cgacttctct gtgagtgtcg agcgagcact     2100

ggctgcaaag cctggcctgg atacctacag tctgggagga ggaggagcag ctcgagtgag     2160

ggtcagaggg tcaacaggag tggcagcagc tgcaggactg caccgatatc tgcgagactt     2220

ttgcggctgt catgtggcct ggtcaggaag ccagctgagg ctgcccagac ctctgccagc     2280

agtgccaggc gagctgacag aagccactcc caaccggtac cgctactatc agaatgtgtg     2340

cacccagtcc tattctttcg tctggtggga ctgggctcga tgggagcgcg aaatcgattg     2400

gatggcactg aacggaatta atctggcact ggcatggagc ggacaggagg caatctggca     2460

gagagtgtac ctggcactgg gactgactca ggccgagatt aacgagttct tcaccgggcc     2520

agcttttctg gcatggggac ggatggggaa tctgcacaca tgggacggac cactgccacc     2580

ttcttggcac atcaagcagc tgtatctgca gcatagggtg ctggatcaga tgagaagttt     2640

tggcatgact ccagtgctgc ccgctttcgc aggacacgtc cctgaggccg tgaccagggt     2700

gttcccacag gtgaacgtca ctaagatggg cagctgggga cattttaatt gcagttactc     2760

atgtagcttc ctgctggccc ctgaagaccc aatttttccc atcattggca gcctgttcct     2820

gcgggagctg atcaaagaat ttggaaccga ccacatctac ggggccgata cattcaacga     2880

gatgcagcca cccagctccg aaccttccta cctggccgct gcaaccacag cagtgtatga     2940

ggccatgacc gctgtggaca cagaagccgt ctggctgctg caggggtggc tgtttcagca     3000

tcagccacag ttctggggac ctgcacagat ccgagctgtg ctgggagcag tcccacgagg     3060

aaggctgctg gtgctggatc tgtttgccga gtcccagccc gtctacacta ggaccgcttc     3120

tttccagggc cagcctttta tttggtgtat gctgcacaac tttggaggga atcatgggct     3180

gttcggagca ctggaggcag tgaacggagg accagaagca gctagactgt ttcctaattc     3240

tactatggtg ggcaccggaa tggctcccga gggcatctca cagaatgaag tggtctacag     3300

cctgatggca gagctgggat ggcgaaagga cccagtgcct gatctggcag cctgggtcac     3360

tagtttcgct gcaaggagat acggggtgtc acaccctgac gctggagcag cttggcgact     3420

gctgctgagg tctgtgtata actgcagtgg ggaggcctgt agaggccata atcgatcccc     3480

actggtgcgg cgaccatcac tgcagatgaa caccagcatt tggtacaatc gatccgatgt     3540

gtttgaagct tggaggctgc tgctgacaag tgccccttca ctggctactt ctccagcatt     3600

cagatatgac ctgctggatc tgacacggca ggcagtgcag gagctggtca gcctgtacta     3660

tgaggaagct cgcagcgcat acctgtccaa agaactggca tccctgctga gggcaggagg     3720

agtgctggct tatgagctgc tgccagctct ggacgaagtc ctggcatccg attctcgctt     3780

tctgctggga agctggctgg agcaggcccg agcagccgct gtgtccgagg ccgaagctga     3840

cttctacgag cagaactcta ggtatcagct gactctgtgg ggacccgaag ggaacatcct     3900

ggattacgcc aataagcagc tggccggact ggtggctaat tactataccc ctagatggcg     3960

gctgttcctg gaggcactgg tggacagcgt cgctcagggg attccattcc agcagcacca     4020

gtttgataag aacgtgttcc agctggaaca ggcctttgtc ctgtctaaac agcggtaccc     4080

tagtcagcca cgcggggaca cagtggatct ggctaagaaa atcttcctga aatactatcc     4140

tagatgggtc gccggcagct ggtgagaatt cgagctcggt acccgggaat caattcactc     4200

ctcaggtgca ggctgcctat cagaaggtgg tggctggtgt ggccaatgcc ctggctcaca     4260

aataccactg agatcttttt ccctctgcca aaaattatgg ggacatcatg aagccccttg     4320

agcatctgac ttctggctaa taaaggaaat ttattttcat tgcaatagtg tgttggaatt     4380

ttttgtgtct ctcactcgga aggacatatg ggagggcaaa tcatttaaaa catcagaatg     4440

agtatttggt ttagagtttg gcaacatatg cccatatgct ggctgccatg aacaaaggtt     4500

ggctataaag aggtcatcag tatatgaaac agccccctgc tgtccattcc ttattccata     4560

gaaaagcctt gacttgaggt tagatttttt ttatattttg ttttgtgtta tttttttctt     4620

taacatccct aaaattttcc ttacatgttt tactagccag atttttcctc ctctcctgac     4680

tactcccagt catagctgtc cctcttctct tatggagatc cctcgacctg cagcccaagc     4740

tgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     4800

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggctt tgcccgggcg     4860

gcctcagtga gcgagcgagc gcgcag                                          4886


