                         SEQUENCE LISTING

<110>  Technische Universitt Mnchen
 
<120>  Glypican-3-specific T-cell receptors and their uses for 
       immunotherapy of hepatocellular carcinoma

<130>  U30560WO

<150>  EP 14 168 107.2
<151>  2014-05-13

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Glu Leu Ile Pro Leu Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Thr Ala Arg Ala Gln Ser Val Thr Gln Pro Asp Ile His Ile Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Asn Tyr Ser Tyr Gly Ala 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Ser Pro Gly Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Thr Leu Val Gln Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Arg Ser Gln Ser Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Trp Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Gly Val Leu Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Thr Ile Ile Pro 
    130                 


<210>  2
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Glu 
            100                 105                 110         


Asp Thr Ala Tyr Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu 
    130     


<210>  3
<211>  136
<212>  PRT
<213>  Mus musculus

<400>  3

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
65                  70                  75                  80  


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
                85                  90                  95      


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
            100                 105                 110         


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
        115                 120                 125             


Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135     


<210>  4
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  4

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170             


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A linker

<400>  5

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  6
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha chain of TCR P1-1

<400>  6

Met Leu Leu Glu Leu Ile Pro Leu Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Thr Ala Arg Ala Gln Ser Val Thr Gln Pro Asp Ile His Ile Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Asn Tyr Ser Tyr Gly Ala 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Ser Pro Gly Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Thr Leu Val Gln Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Arg Ser Gln Ser Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Trp Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Gly Val Leu Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Thr Ile Ile Pro Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  7
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta chain of TCR P1-1

<400>  7

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Glu 
            100                 105                 110         


Asp Thr Ala Tyr Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


<210>  8
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR P1-1

<400>  8

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Glu 
            100                 105                 110         


Asp Thr Ala Tyr Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
305                 310                 315                 320 


Glu Glu Asn Pro Gly Pro Met Leu Leu Glu Leu Ile Pro Leu Leu Gly 
                325                 330                 335     


Ile His Phe Val Leu Arg Thr Ala Arg Ala Gln Ser Val Thr Gln Pro 
            340                 345                 350         


Asp Ile His Ile Thr Val Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys 
        355                 360                 365             


Asn Tyr Ser Tyr Gly Ala Thr Pro Tyr Leu Phe Trp Tyr Val Gln Ser 
    370                 375                 380                 


Pro Gly Gln Gly Leu Gln Leu Leu Leu Lys Tyr Phe Ser Gly Asp Thr 
385                 390                 395                 400 


Leu Val Gln Gly Ile Lys Gly Phe Glu Ala Glu Phe Lys Arg Ser Gln 
                405                 410                 415     


Ser Ser Phe Asn Leu Arg Lys Pro Ser Val His Trp Ser Asp Ala Ala 
            420                 425                 430         


Glu Tyr Phe Cys Ala Val Gly Val Leu Asn Phe Gly Asn Glu Lys Leu 
        435                 440                 445             


Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Ile Gln Asn Pro 
    450                 455                 460                 


Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr 
465                 470                 475                 480 


Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr 
                485                 490                 495     


Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys 
            500                 505                 510         


Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr 
        515                 520                 525             


Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro 
    530                 535                 540                 


Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu 
545                 550                 555                 560 


Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg 
                565                 570                 575     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            580                 585                 590         


Leu Trp Ser Ser 
        595     


<210>  9
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  9
atgctgctgg aactgatccc tctgctgggc atccacttcg tgctgagaac cgccagagcc       60

cagagcgtga cccagcccga tatccacatc accgtgtctg agggcgccag cctggaactg      120

cggtgcaact acagctacgg cgccaccccc tacctgtttt ggtacgtgca gagccccgga      180

cagggcctgc agctgctgct gaagtacttt agcggcgaca ccctggtgca gggcatcaag      240

ggattcgagg ccgagttcaa gcggagccag agcagcttca acctgcggaa gccctccgtg      300

cattggagcg acgccgccga gtacttttgt gccgtgggcg tgctgaactt cggcaacgag      360

aagctgacct ttggcaccgg cacccggctg accatcatcc ct                         402


<210>  10
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  10
atgctgtgtt ctctgctggc tctgctgctg ggcaccttct ttggagtgcg gagccagacc       60

atccaccagt ggcctgctac actggtgcag cctgtgggca gccctctgag cctggaatgt      120

accgtggaag gcaccagcaa ccccaacctg tactggtaca gacaggccgc tggcagaggc      180

ctgcagctgc tgttttacag cgtgggcatc ggccagatca gcagcgaggt gccccagaat      240

ctgagcgcca gcagacccca ggaccggcag tttatcctga gcagcaagaa gctgctgctg      300

agcgacagcg gcttctacct gtgcgcttgg agcgaggaca ccgcctacta cggctacacc      360

tttggcagcg gcacccggct gacagtggtg gaa                                   393


<210>  11
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain of TCR P1-1

<400>  11
atgctgctgg aactgatccc tctgctgggc atccacttcg tgctgagaac cgccagagcc       60

cagagcgtga cccagcccga tatccacatc accgtgtctg agggcgccag cctggaactg      120

cggtgcaact acagctacgg cgccaccccc tacctgtttt ggtacgtgca gagccccgga      180

cagggcctgc agctgctgct gaagtacttt agcggcgaca ccctggtgca gggcatcaag      240

ggattcgagg ccgagttcaa gcggagccag agcagcttca acctgcggaa gccctccgtg      300

cattggagcg acgccgccga gtacttttgt gccgtgggcg tgctgaactt cggcaacgag      360

aagctgacct ttggcaccgg cacccggctg accatcatcc ctatccagaa ccccgagccc      420

gccgtgtacc agctgaagga ccccagaagc caggacagca ccctgtgtct gttcaccgac      480

ttcgacagcc agatcaacgt gcccaagacc atggaaagcg gcaccttcat caccgataag      540

tgcgtgctgg acatgaaggc catggacagc aagagcaacg gcgccattgc ctggtccaac      600

cagaccagct tcacatgcca ggacatcttc aaagagacaa acgccaccta cccttccagc      660

gacgtgccct gtgacgccac cctgaccgag aagtccttcg agacagacat gaatctgaat      720

ttccagaacc tgagcgtgat gggcctgcgg atcctgctgc tgaaagtggc cggcttcaac      780

ctgctgatga ccctgcggct gtggtccagc tga                                   813


<210>  12
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain of TCR P1-1

<400>  12
atgctgtgtt ctctgctggc tctgctgctg ggcaccttct ttggagtgcg gagccagacc       60

atccaccagt ggcctgctac actggtgcag cctgtgggca gccctctgag cctggaatgt      120

accgtggaag gcaccagcaa ccccaacctg tactggtaca gacaggccgc tggcagaggc      180

ctgcagctgc tgttttacag cgtgggcatc ggccagatca gcagcgaggt gccccagaat      240

ctgagcgcca gcagacccca ggaccggcag tttatcctga gcagcaagaa gctgctgctg      300

agcgacagcg gcttctacct gtgcgcttgg agcgaggaca ccgcctacta cggctacacc      360

tttggcagcg gcacccggct gacagtggtg gaagaagatc tgaggaacgt gacccccccc      420

aaggtgtccc tgttcgagcc cagcaaggcc gagatcgcca acaagcagaa agccaccctc      480

gtgtgcctgg ccagaggctt cttccccgac cacgtggaac tgtcctggtg ggtcaacggc      540

aaagaggtgc acagcggagt ctgcaccgac ccccaggctt acaaagagag caactacagc      600

tactgcctgt ccagcagact gcgggtgtcc gctaccttct ggcacaaccc ccggaaccac      660

ttcagatgcc aggtgcagtt ccacggcctg agcgaagagg acaagtggcc cgagggcagc      720

cccaagcccg tgacccagaa tatcagcgcc gaggcctggg gcagagccga ttgtggcatc      780

accagcgcca gctaccacca gggggtgctg agcgccacca tcctgtacga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg tccggactgg tgctgatggc catggtcaag      900

aagaagaaca gc                                                          912


<210>  13
<211>  1791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR P1-1

<400>  13
atgctgtgtt ctctgctggc tctgctgctg ggcaccttct ttggagtgcg gagccagacc       60

atccaccagt ggcctgctac actggtgcag cctgtgggca gccctctgag cctggaatgt      120

accgtggaag gcaccagcaa ccccaacctg tactggtaca gacaggccgc tggcagaggc      180

ctgcagctgc tgttttacag cgtgggcatc ggccagatca gcagcgaggt gccccagaat      240

ctgagcgcca gcagacccca ggaccggcag tttatcctga gcagcaagaa gctgctgctg      300

agcgacagcg gcttctacct gtgcgcttgg agcgaggaca ccgcctacta cggctacacc      360

tttggcagcg gcacccggct gacagtggtg gaagaagatc tgaggaacgt gacccccccc      420

aaggtgtccc tgttcgagcc cagcaaggcc gagatcgcca acaagcagaa agccaccctc      480

gtgtgcctgg ccagaggctt cttccccgac cacgtggaac tgtcctggtg ggtcaacggc      540

aaagaggtgc acagcggagt ctgcaccgac ccccaggctt acaaagagag caactacagc      600

tactgcctgt ccagcagact gcgggtgtcc gctaccttct ggcacaaccc ccggaaccac      660

ttcagatgcc aggtgcagtt ccacggcctg agcgaagagg acaagtggcc cgagggcagc      720

cccaagcccg tgacccagaa tatcagcgcc gaggcctggg gcagagccga ttgtggcatc      780

accagcgcca gctaccacca gggggtgctg agcgccacca tcctgtacga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg tccggactgg tgctgatggc catggtcaag      900

aagaagaaca gcggcagcgg cgccaccaac ttcagcctgc tgaagcaggc cggcgacgtg      960

gaagagaacc ccgggcccat gctgctggaa ctgatccctc tgctgggcat ccacttcgtg     1020

ctgagaaccg ccagagccca gagcgtgacc cagcccgata tccacatcac cgtgtctgag     1080

ggcgccagcc tggaactgcg gtgcaactac agctacggcg ccacccccta cctgttttgg     1140

tacgtgcaga gccccggaca gggcctgcag ctgctgctga agtactttag cggcgacacc     1200

ctggtgcagg gcatcaaggg attcgaggcc gagttcaagc ggagccagag cagcttcaac     1260

ctgcggaagc cctccgtgca ttggagcgac gccgccgagt acttttgtgc cgtgggcgtg     1320

ctgaacttcg gcaacgagaa gctgaccttt ggcaccggca cccggctgac catcatccct     1380

atccagaacc ccgagcccgc cgtgtaccag ctgaaggacc ccagaagcca ggacagcacc     1440

ctgtgtctgt tcaccgactt cgacagccag atcaacgtgc ccaagaccat ggaaagcggc     1500

accttcatca ccgataagtg cgtgctggac atgaaggcca tggacagcaa gagcaacggc     1560

gccattgcct ggtccaacca gaccagcttc acatgccagg acatcttcaa agagacaaac     1620

gccacctacc cttccagcga cgtgccctgt gacgccaccc tgaccgagaa gtccttcgag     1680

acagacatga atctgaattt ccagaacctg agcgtgatgg gcctgcggat cctgctgctg     1740

aaagtggccg gcttcaacct gctgatgacc ctgcggctgt ggtccagctg a              1791


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Ile Asp Lys Lys Val Leu Lys Val 
1               5                   


<210>  15
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  16
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  16
atggccggga ccgtgcgcac cgcgtgcttg gtggtggcga tgctgctcag cttggacttc       60

ccgggacagg cgcagccccc gccgccgccg ccggacgcca cctgtcacca agtccgctcc      120

ttcttccaga gactgcagcc cggactcaag tgggtgccag aaactcccgt gccaggatca      180

gatttgcaag tatgtctccc taagggccca acatgctgct caagaaagat ggaagaaaaa      240

taccaactaa cagcacgatt gaacatggaa cagctgcttc agtctgcaag tatggagctc      300

aagttcttaa ttattcagaa tgctgcggtt ttccaagagg cctttgaaat tgttgttcgc      360

catgccaaga actacaccaa tgccatgttc aagaacaact acccaagcct gactccacaa      420

gcttttgagt ttgtgggtga atttttcaca gatgtgtctc tctacatctt gggttctgac      480

atcaatgtag atgacatggt caatgaattg tttgacagcc tgtttccagt catctatacc      540

cagctaatga acccaggcct gcctgattca gccttggaca tcaatgagtg cctccgagga      600

gcaagacgtg acctgaaagt atttgggaat ttccccaagc ttattatgac ccaggtttcc      660

aagtcactgc aagtcactag gatcttcctt caggctctga atcttggaat tgaagtgatc      720

aacacaactg atcacctgaa gttcagtaag gactgtggcc gaatgctcac cagaatgtgg      780

tactgctctt actgccaggg actgatgatg gttaaaccct gtggcggtta ctgcaatgtg      840

gtcatgcaag gctgtatggc aggtgtggtg gagattgaca agtactggag agaatacatt      900

ctgtcccttg aagaacttgt gaatggcatg tacagaatct atgacatgga gaacgtactg      960

cttggtctct tttcaacaat ccatgattct atccagtatg tccagaagaa tgcaggaaag     1020

ctgaccacca ctattggcaa gttatgtgcc cattctcaac aacgccaata tagatctgct     1080

tattatcctg aagatctctt tattgacaag aaagtattaa aagttgctca tgtagaacat     1140

gaagaaacct tatccagccg aagaagggaa ctaattcaga agttgaagtc tttcatcagc     1200

ttctatagtg ctttgcctgg ctacatctgc agccatagcc ctgtggcgga aaacgacacc     1260

ctttgctgga atggacaaga actcgtggag agatacagcc aaaaggcagc aaggaatgga     1320

atgaaaaacc agttcaatct ccatgagctg aaaatgaagg gccctgagcc agtggtcagt     1380

caaattattg acaaactgaa gcacattaac cagctcctga gaaccatgtc tatgcccaaa     1440

ggtagagttc tggataaaaa cctggatgag gaagggtttg aaagtggaga ctgcggtgat     1500

gatgaagatg agtgcattgg aggctctggt gatggaatga taaaagtgaa gaatcagctc     1560

cgcttccttg cagaactggc ctatgatctg gatgtggatg atgcgcctgg aaacagtcag     1620

caggcaactc cgaaggacaa cgagataagc acctttcaca acctcgggaa cgttcattcc     1680

ccgctgaagc ttctcaccag catggccatc tcggtggtgt gcttcttctt cctggtgcac     1740

tga                                                                   1743


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Ile His Asp Ser Ile Gln Tyr Val 
1               5                   


<210>  18
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Lys Met Lys Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro Gly Thr Ser 
        115                 120                 125             


Leu Ser Val Ile Pro 
    130             


<210>  19
<211>  142
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Gly 
            100                 105                 110         


Tyr Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu Ile Ile Gln Pro Glu Asp Leu Arg Asn Val Thr Pro Xaa 
    130                 135                 140         


<210>  20
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Asn Gly Gln Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Ile Asn 
    130     


<210>  21
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ile Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu 
    130             


<210>  22
<211>  136
<212>  PRT
<213>  Mus musculus

<400>  22

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
65                  70                  75                  80  


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
                85                  90                  95      


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
            100                 105                 110         


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
        115                 120                 125             


Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135     


<210>  23
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170             


<210>  24
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain of TCR P2-1 (with variable alpha of SEQ ID NO. 18)

<400>  24

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Lys Met Lys Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro Gly Thr Ser 
        115                 120                 125             


Leu Ser Val Ile Pro Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  25
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain of TCR P2-1 (with variable alpha of SEQ ID NO. 19)


<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Gly 
            100                 105                 110         


Tyr Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu Ile Ile Gln Pro Glu Asp Leu Arg Asn Val Thr Pro Xaa Ile Gln 
    130                 135                 140                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
145                 150                 155                 160 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                165                 170                 175     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            180                 185                 190         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        195                 200                 205             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    210                 215                 220                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly 
                245                 250                 255     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser 
        275             


<210>  26
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha chain of TCR P2-1 (with variable alpha of SEQ ID NO. 20)

<400>  26

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Asn Gly Gln Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Ile Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  27
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta chain of TCR P2-1

<400>  27

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ile Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  28
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR P2-1 (with variable alpha of SEQ ID NO. 18)

<400>  28

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ile Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
305                 310                 315                 320 


Asp Val Glu Glu Asn Pro Gly Pro Met Lys Ser Leu Arg Val Leu Leu 
                325                 330                 335     


Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu 
            340                 345                 350         


Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala 
        355                 360                 365             


Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp 
    370                 375                 380                 


Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Phe Ile Tyr 
385                 390                 395                 400 


Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys 
                405                 410                 415     


Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp 
            420                 425                 430         


Ser Ala Thr Tyr Leu Cys Ala Ala Lys Met Lys Thr Ser Tyr Asp Lys 
        435                 440                 445             


Val Ile Phe Gly Pro Gly Thr Ser Leu Ser Val Ile Pro Ile Gln Asn 
    450                 455                 460                 


Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser 
465                 470                 475                 480 


Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys 
                485                 490                 495     


Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met 
            500                 505                 510         


Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln 
        515                 520                 525             


Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr 
    530                 535                 540                 


Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe 
545                 550                 555                 560 


Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu 
                565                 570                 575     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            580                 585                 590         


Arg Leu Trp Ser Ser 
        595         


<210>  29
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR P2-1 (with variable alpha of SEQ ID NO. 19)


<220>
<221>  misc_feature
<222>  (470)..(470)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ile Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
305                 310                 315                 320 


Asp Val Glu Glu Asn Pro Gly Pro Met Lys Ser Leu Arg Val Leu Leu 
                325                 330                 335     


Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu 
            340                 345                 350         


Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala 
        355                 360                 365             


Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp 
    370                 375                 380                 


Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Phe Ile Tyr 
385                 390                 395                 400 


Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys 
                405                 410                 415     


Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp 
            420                 425                 430         


Ser Ala Thr Tyr Leu Cys Ala Gly Tyr Ser Gly Gly Gly Ala Asp Gly 
        435                 440                 445             


Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro Glu Asp Leu 
    450                 455                 460                 


Arg Asn Val Thr Pro Xaa Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
            500                 505                 510         


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
        515                 520                 525             


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
    530                 535                 540                 


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
545                 550                 555                 560 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
                565                 570                 575     


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
            580                 585                 590         


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605     


<210>  30
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR P2-1 (with variable alpha of SEQ ID NO. 20)

<400>  30

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ile Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
305                 310                 315                 320 


Asp Val Glu Glu Asn Pro Gly Pro Met Thr Ser Ile Arg Ala Val Phe 
                325                 330                 335     


Ile Phe Leu Trp Leu Gln Leu Asp Leu Val Asn Gly Glu Asn Val Glu 
            340                 345                 350         


Gln His Pro Ser Thr Leu Ser Val Gln Glu Gly Asp Ser Ala Val Ile 
        355                 360                 365             


Lys Cys Thr Tyr Ser Asp Ser Ala Ser Asn Tyr Phe Pro Trp Tyr Lys 
    370                 375                 380                 


Gln Glu Leu Gly Lys Arg Pro Gln Leu Ile Ile Asp Ile Arg Ser Asn 
385                 390                 395                 400 


Val Gly Glu Lys Lys Asp Gln Arg Ile Ala Val Thr Leu Asn Lys Thr 
                405                 410                 415     


Ala Lys His Phe Ser Leu His Ile Thr Glu Thr Gln Pro Glu Asp Ser 
            420                 425                 430         


Ala Val Tyr Phe Cys Ala Ala Ser Asn Gly Gln Gly Ala Gln Lys Leu 
        435                 440                 445             


Val Phe Gly Gln Gly Thr Arg Leu Thr Ile Asn Ile Gln Asn Pro Glu 
    450                 455                 460                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
465                 470                 475                 480 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                485                 490                 495     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala 
            500                 505                 510         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        515                 520                 525             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    530                 535                 540                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
545                 550                 555                 560 


Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile 
                565                 570                 575     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            580                 585                 590         


Trp Ser Ser 
        595 


<210>  31
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  31
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc       60

caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc      120

tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat      180

tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga      240

aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc      300

cagcccagtg attcagccac ctacctctgt gccgcgaaaa tgaaaacctc ctacgacaag      360

gtgatatttg ggccagggac aagcttatca gtcattcca                             399


<210>  32
<211>  425
<212>  DNA
<213>  Homo sapiens

<400>  32
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc       60

caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc      120

tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat      180

tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga      240

aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc      300

cagcccagtg attcagccac ctacctctgt gccgggtatt caggaggagg tgctgacgga      360

ctcacctttg gcaaagggac tcatctaatc atccagcccg aagatctgag gaacgtgacc      420

ccccc                                                                  425


<210>  33
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  33
atgacatcca ttcgagctgt atttatattc ctgtggctgc agctggactt ggtgaatgga       60

gagaatgtgg agcagcatcc ttcaaccctg agtgtccagg agggagacag cgctgttatc      120

aagtgtactt attcagacag tgcctcaaac tacttccctt ggtataagca agaacttgga      180

aaaagacctc agcttattat agacattcgt tcaaatgtgg gcgaaaagaa agaccaacga      240

attgctgtta cattgaacaa gacagccaaa catttctccc tgcacatcac agagacccaa      300

cctgaagact cggctgtcta cttctgtgca gcaagtaatg ggcagggagc ccagaagctg      360

gtatttggcc aaggaaccag gctgactatc aac                                   393


<210>  34
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  34
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcc ccggggggat cgggtacgag      360

cagtacttcg ggccgggcac caggctcacg gtcacagag                             399


<210>  35
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain of TCR P2-1 (with variable alpha of SEQ ID NO. 31)

<400>  35
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc       60

caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc      120

tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat      180

tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga      240

aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc      300

cagcccagtg attcagccac ctacctctgt gccgcgaaaa tgaaaacctc ctacgacaag      360

gtgatatttg ggccagggac aagcttatca gtcattccaa tccagaaccc cgagcccgcc      420

gtgtaccagc tgaaggaccc cagaagccag gacagcaccc tgtgtctgtt caccgacttc      480

gacagccaga tcaacgtgcc caagaccatg gaaagcggca ccttcatcac cgataagtgc      540

gtgctggaca tgaaggccat ggacagcaag agcaacggcg ccattgcctg gtccaaccag      600

accagcttca catgccagga catcttcaaa gagacaaacg ccacctaccc ttccagcgac      660

gtgccctgtg acgccaccct gaccgagaag tccttcgaga cagacatgaa tctgaatttc      720

cagaacctga gcgtgatggg cctgcggatc ctgctgctga aagtggccgg cttcaacctg      780

ctgatgaccc tgcggctgtg gtccagctga                                       810


<210>  36
<211>  836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain of TCR P2-1 (with variable alpha of SEQ ID NO. 32)

<400>  36
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc       60

caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc      120

tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat      180

tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga      240

aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc      300

cagcccagtg attcagccac ctacctctgt gccgggtatt caggaggagg tgctgacgga      360

ctcacctttg gcaaagggac tcatctaatc atccagcccg aagatctgag gaacgtgacc      420

cccccatcca gaaccccgag cccgccgtgt accagctgaa ggaccccaga agccaggaca      480

gcaccctgtg tctgttcacc gacttcgaca gccagatcaa cgtgcccaag accatggaaa      540

gcggcacctt catcaccgat aagtgcgtgc tggacatgaa ggccatggac agcaagagca      600

acggcgccat tgcctggtcc aaccagacca gcttcacatg ccaggacatc ttcaaagaga      660

caaacgccac ctacccttcc agcgacgtgc cctgtgacgc caccctgacc gagaagtcct      720

tcgagacaga catgaatctg aatttccaga acctgagcgt gatgggcctg cggatcctgc      780

tgctgaaagt ggccggcttc aacctgctga tgaccctgcg gctgtggtcc agctga          836


<210>  37
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha chain of TCR P2-1 (with variable alpha of SEQ ID NO. 33)

<400>  37
atgacatcca ttcgagctgt atttatattc ctgtggctgc agctggactt ggtgaatgga       60

gagaatgtgg agcagcatcc ttcaaccctg agtgtccagg agggagacag cgctgttatc      120

aagtgtactt attcagacag tgcctcaaac tacttccctt ggtataagca agaacttgga      180

aaaagacctc agcttattat agacattcgt tcaaatgtgg gcgaaaagaa agaccaacga      240

attgctgtta cattgaacaa gacagccaaa catttctccc tgcacatcac agagacccaa      300

cctgaagact cggctgtcta cttctgtgca gcaagtaatg ggcagggagc ccagaagctg      360

gtatttggcc aaggaaccag gctgactatc aacatccaga accccgagcc cgccgtgtac      420

cagctgaagg accccagaag ccaggacagc accctgtgtc tgttcaccga cttcgacagc      480

cagatcaacg tgcccaagac catggaaagc ggcaccttca tcaccgataa gtgcgtgctg      540

gacatgaagg ccatggacag caagagcaac ggcgccattg cctggtccaa ccagaccagc      600

ttcacatgcc aggacatctt caaagagaca aacgccacct acccttccag cgacgtgccc      660

tgtgacgcca ccctgaccga gaagtccttc gagacagaca tgaatctgaa tttccagaac      720

ctgagcgtga tgggcctgcg gatcctgctg ctgaaagtgg ccggcttcaa cctgctgatg      780

accctgcggc tgtggtccag ctga                                             804


<210>  38
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta chain of TCR P2-1

<400>  38
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcc ccggggggat cgggtacgag      360

cagtacttcg ggccgggcac caggctcacg gtcacagagg aagatctgag gaacgtgacc      420

ccccccaagg tgtccctgtt cgagcccagc aaggccgaga tcgccaacaa gcagaaagcc      480

accctcgtgt gcctggccag aggcttcttc cccgaccacg tggaactgtc ctggtgggtc      540

aacggcaaag aggtgcacag cggagtctgc accgaccccc aggcttacaa agagagcaac      600

tacagctact gcctgtccag cagactgcgg gtgtccgcta ccttctggca caacccccgg      660

aaccacttca gatgccaggt gcagttccac ggcctgagcg aagaggacaa gtggcccgag      720

ggcagcccca agcccgtgac ccagaatatc agcgccgagg cctggggcag agccgattgt      780

ggcatcacca gcgccagcta ccaccagggg gtgctgagcg ccaccatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtccg gactggtgct gatggccatg      900

gtcaagaaga agaacagc                                                    918


<210>  39
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR P2-1 (with variable alpha of SEQ ID NO. 31)

<400>  39
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcc ccggggggat cgggtacgag      360

cagtacttcg ggccgggcac caggctcacg gtcacagagg aagatctgag gaacgtgacc      420

ccccccaagg tgtccctgtt cgagcccagc aaggccgaga tcgccaacaa gcagaaagcc      480

accctcgtgt gcctggccag aggcttcttc cccgaccacg tggaactgtc ctggtgggtc      540

aacggcaaag aggtgcacag cggagtctgc accgaccccc aggcttacaa agagagcaac      600

tacagctact gcctgtccag cagactgcgg gtgtccgcta ccttctggca caacccccgg      660

aaccacttca gatgccaggt gcagttccac ggcctgagcg aagaggacaa gtggcccgag      720

ggcagcccca agcccgtgac ccagaatatc agcgccgagg cctggggcag agccgattgt      780

ggcatcacca gcgccagcta ccaccagggg gtgctgagcg ccaccatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtccg gactggtgct gatggccatg      900

gtcaagaaga agaacagcgg cagcggcgcc accaacttca gcctgctgaa gcaggccggc      960

gacgtggaag agaaccccgg gcccatgaaa tccttgagag ttttactagt gatcctgtgg     1020

cttcagttga gctgggtttg gagccaacag aaggaggtgg agcagaattc tggacccctc     1080

agtgttccag agggagccat tgcctctctc aactgcactt acagtgaccg aggttcccag     1140

tccttcttct ggtacagaca atattctggg aaaagccctg agttgataat gttcatatac     1200

tccaatggtg acaaagaaga tggaaggttt acagcacagc tcaataaagc cagccagtat     1260

gtttctctgc tcatcagaga ctcccagccc agtgattcag ccacctacct ctgtgccgcg     1320

aaaatgaaaa cctcctacga caaggtgata tttgggccag ggacaagctt atcagtcatt     1380

ccaatccaga accccgagcc cgccgtgtac cagctgaagg accccagaag ccaggacagc     1440

accctgtgtc tgttcaccga cttcgacagc cagatcaacg tgcccaagac catggaaagc     1500

ggcaccttca tcaccgataa gtgcgtgctg gacatgaagg ccatggacag caagagcaac     1560

ggcgccattg cctggtccaa ccagaccagc ttcacatgcc aggacatctt caaagagaca     1620

aacgccacct acccttccag cgacgtgccc tgtgacgcca ccctgaccga gaagtccttc     1680

gagacagaca tgaatctgaa tttccagaac ctgagcgtga tgggcctgcg gatcctgctg     1740

ctgaaagtgg ccggcttcaa cctgctgatg accctgcggc tgtggtccag ctga           1794


<210>  40
<211>  1820
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR P2-1 (with variable alpha of SEQ ID NO. 32)

<400>  40
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcc ccggggggat cgggtacgag      360

cagtacttcg ggccgggcac caggctcacg gtcacagagg aagatctgag gaacgtgacc      420

ccccccaagg tgtccctgtt cgagcccagc aaggccgaga tcgccaacaa gcagaaagcc      480

accctcgtgt gcctggccag aggcttcttc cccgaccacg tggaactgtc ctggtgggtc      540

aacggcaaag aggtgcacag cggagtctgc accgaccccc aggcttacaa agagagcaac      600

tacagctact gcctgtccag cagactgcgg gtgtccgcta ccttctggca caacccccgg      660

aaccacttca gatgccaggt gcagttccac ggcctgagcg aagaggacaa gtggcccgag      720

ggcagcccca agcccgtgac ccagaatatc agcgccgagg cctggggcag agccgattgt      780

ggcatcacca gcgccagcta ccaccagggg gtgctgagcg ccaccatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtccg gactggtgct gatggccatg      900

gtcaagaaga agaacagcgg cagcggcgcc accaacttca gcctgctgaa gcaggccggc      960

gacgtggaag agaaccccgg gcccatgaaa tccttgagag ttttactagt gatcctgtgg     1020

cttcagttga gctgggtttg gagccaacag aaggaggtgg agcagaattc tggacccctc     1080

agtgttccag agggagccat tgcctctctc aactgcactt acagtgaccg aggttcccag     1140

tccttcttct ggtacagaca atattctggg aaaagccctg agttgataat gttcatatac     1200

tccaatggtg acaaagaaga tggaaggttt acagcacagc tcaataaagc cagccagtat     1260

gtttctctgc tcatcagaga ctcccagccc agtgattcag ccacctacct ctgtgccggg     1320

tattcaggag gaggtgctga cggactcacc tttggcaaag ggactcatct aatcatccag     1380

cccgaagatc tgaggaacgt gaccccccca tccagaaccc cgagcccgcc gtgtaccagc     1440

tgaaggaccc cagaagccag gacagcaccc tgtgtctgtt caccgacttc gacagccaga     1500

tcaacgtgcc caagaccatg gaaagcggca ccttcatcac cgataagtgc gtgctggaca     1560

tgaaggccat ggacagcaag agcaacggcg ccattgcctg gtccaaccag accagcttca     1620

catgccagga catcttcaaa gagacaaacg ccacctaccc ttccagcgac gtgccctgtg     1680

acgccaccct gaccgagaag tccttcgaga cagacatgaa tctgaatttc cagaacctga     1740

gcgtgatggg cctgcggatc ctgctgctga aagtggccgg cttcaacctg ctgatgaccc     1800

tgcggctgtg gtccagctga                                                 1820


<210>  41
<211>  1788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR P2-1 (with variable alpha of SEQ ID NO. 33)

<400>  41
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctgg agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcc ccggggggat cgggtacgag      360

cagtacttcg ggccgggcac caggctcacg gtcacagagg aagatctgag gaacgtgacc      420

ccccccaagg tgtccctgtt cgagcccagc aaggccgaga tcgccaacaa gcagaaagcc      480

accctcgtgt gcctggccag aggcttcttc cccgaccacg tggaactgtc ctggtgggtc      540

aacggcaaag aggtgcacag cggagtctgc accgaccccc aggcttacaa agagagcaac      600

tacagctact gcctgtccag cagactgcgg gtgtccgcta ccttctggca caacccccgg      660

aaccacttca gatgccaggt gcagttccac ggcctgagcg aagaggacaa gtggcccgag      720

ggcagcccca agcccgtgac ccagaatatc agcgccgagg cctggggcag agccgattgt      780

ggcatcacca gcgccagcta ccaccagggg gtgctgagcg ccaccatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtccg gactggtgct gatggccatg      900

gtcaagaaga agaacagcgg cagcggcgcc accaacttca gcctgctgaa gcaggccggc      960

gacgtggaag agaaccccgg gcccatgaca tccattcgag ctgtatttat attcctgtgg     1020

ctgcagctgg acttggtgaa tggagagaat gtggagcagc atccttcaac cctgagtgtc     1080

caggagggag acagcgctgt tatcaagtgt acttattcag acagtgcctc aaactacttc     1140

ccttggtata agcaagaact tggaaaaaga cctcagctta ttatagacat tcgttcaaat     1200

gtgggcgaaa agaaagacca acgaattgct gttacattga acaagacagc caaacatttc     1260

tccctgcaca tcacagagac ccaacctgaa gactcggctg tctacttctg tgcagcaagt     1320

aatgggcagg gagcccagaa gctggtattt ggccaaggaa ccaggctgac tatcaacatc     1380

cagaaccccg agcccgccgt gtaccagctg aaggacccca gaagccagga cagcaccctg     1440

tgtctgttca ccgacttcga cagccagatc aacgtgccca agaccatgga aagcggcacc     1500

ttcatcaccg ataagtgcgt gctggacatg aaggccatgg acagcaagag caacggcgcc     1560

attgcctggt ccaaccagac cagcttcaca tgccaggaca tcttcaaaga gacaaacgcc     1620

acctaccctt ccagcgacgt gccctgtgac gccaccctga ccgagaagtc cttcgagaca     1680

gacatgaatc tgaatttcca gaacctgagc gtgatgggcc tgcggatcct gctgctgaaa     1740

gtggccggct tcaacctgct gatgaccctg cggctgtggt ccagctga                  1788


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer (with R = A or G; D = A, G or T)

<400>  42
tgagtgtccc rgarggdr                                                     18


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
gtgacacatt tgtttgagaa tc                                                22


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer (with N = inosine, W = A/T, M = A/C, Y = C/T, K = G/T)


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  44
gcnntktnyt ggtaymgaca                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer (with N = inosine, W = A/T, M = A/C, Y = C/T, K = G/T)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  45
ctntktwttg gtaycnkcag                                                   20


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
gcacctcctt cccattcac                                                    19


