                         SEQUENCE LISTING

<110>  BioNTech AG
 
<120>  Methods and kits for the diagnosis of cancer

<130>  674-125

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  1

Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  2

Gly Gly Ser Thr Gly Asp Ala Asp Gly Pro Gly Gly Pro Gly Ile 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  3

Ala Met Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  4

Gly Asp Ala Asp Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  5

Gly Gly Gly Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ser Gly 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  6

Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  7

Pro Arg Gly Ala Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  8

Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly Gly Pro Gly 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  9

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 peptide

<400>  10

Pro Arg Gly Pro His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p53 peptide

<400>  11

Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  p53 peptide

<400>  12

Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  p53 peptide

<400>  13

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p53 peptide

<400>  14

Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endoplasmin peptide

<400>  15

Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly Asn Met Glu 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K-Ras 2 peptide

<400>  16

Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-1 peptide

<400>  17

Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-3 peptide

<400>  18

Tyr Pro Leu Trp Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-4 peptide

<400>  19

Ser Ser Ser Ser Pro Leu Val Pro Gly Thr Leu Glu Glu Val Pro 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIO and F-actin-binding protein peptide

<400>  20

Ala Gly Ala Phe Gln Ala Gln Asp Glu Gly Arg Ser Gln Gln Pro 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAGE-1 peptide

<400>  21

Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln Val 
1               5                   10                  15  


<210>  22
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  23
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  24
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  25
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  26
<211>  2365
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Gln Glu Asn Pro 
705                 710                 715                 720 


Arg Thr Ser Cys Ala Arg Arg Asp Asn Pro Arg Ala Ser Ser Arg Asn 
                725                 730                 735     


Arg Thr Ile Gln Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
            740                 745                 750         


Asn Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Leu 
        755                 760                 765             


Arg Thr Ser Cys Thr Arg Gln Asp Asn Pro Arg Thr Ser Ser Pro Asn 
    770                 775                 780                 


Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp Asn 
785                 790                 795                 800 


Leu Arg Ala Ser Ser Pro Ile Arg Ala Thr Gln Gln Asp Asn Pro Arg 
                805                 810                 815     


Thr Cys Ile Gln Gln Asn Ile Pro Arg Ser Ser Ser Thr Gln Gln Asp 
            820                 825                 830         


Asn Pro Lys Thr Ser Cys Thr Lys Arg Asp Asn Leu Arg Pro Thr Cys 
        835                 840                 845             


Thr Gln Arg Asp Arg Thr Gln Ser Phe Ser Phe Gln Arg Asp Asn Pro 
    850                 855                 860                 


Gly Thr Ser Ser Ser Gln Cys Cys Thr Gln Lys Glu Asn Leu Arg Pro 
865                 870                 875                 880 


Ser Ser Pro His Arg Ser Thr Gln Trp Asn Asn Pro Arg Asn Ser Ser 
                885                 890                 895     


Pro His Arg Thr Asn Lys Asp Ile Pro Trp Ala Ser Phe Pro Leu Arg 
            900                 905                 910         


Pro Thr Gln Ser Asp Gly Pro Arg Thr Ser Ser Pro Ser Arg Ser Lys 
        915                 920                 925             


Gln Ser Glu Val Pro Trp Ala Ser Ile Ala Leu Arg Pro Thr Gln Gly 
    930                 935                 940                 


Asp Arg Pro Gln Thr Ser Ser Pro Ser Arg Pro Ala Gln His Asp Pro 
945                 950                 955                 960 


Pro Gln Ser Ser Phe Gly Pro Thr Gln Tyr Asn Leu Pro Ser Arg Ala 
                965                 970                 975     


Thr Ser Ser Ser His Asn Pro Gly His Gln Ser Thr Ser Arg Thr Ser 
            980                 985                 990         


Ser Pro Val Tyr Pro Ala Ala Tyr  Gly Ala Pro Leu Thr  Ser Pro Glu 
        995                 1000                 1005             


Pro Ser  Gln Pro Pro Cys Ala  Val Cys Ile Gly His  Arg Asp Ala 
    1010                 1015                 1020             


Pro Arg  Ala Ser Ser Pro Pro  Arg Tyr Leu Gln His  Asp Pro Phe 
    1025                 1030                 1035             


Pro Phe  Phe Pro Glu Pro Arg  Ala Pro Glu Ser Glu  Pro Pro His 
    1040                 1045                 1050             


His Glu  Pro Pro Tyr Ile Pro  Pro Ala Val Cys Ile  Gly His Arg 
    1055                 1060                 1065             


Asp Ala  Pro Arg Ala Ser Ser  Pro Pro Arg His Thr  Gln Phe Asp 
    1070                 1075                 1080             


Pro Phe  Pro Phe Leu Pro Asp  Thr Ser Asp Ala Glu  His Gln Cys 
    1085                 1090                 1095             


Gln Ser  Pro Gln His Glu Pro  Leu Gln Leu Pro Ala  Pro Val Cys 
    1100                 1105                 1110             


Ile Gly  Tyr Arg Asp Ala Pro  Arg Ala Ser Ser Pro  Pro Arg Gln 
    1115                 1120                 1125             


Ala Pro  Glu Pro Ser Leu Leu  Phe Gln Asp Leu Pro  Arg Ala Ser 
    1130                 1135                 1140             


Thr Glu  Ser Leu Val Pro Ser  Met Asp Ser Leu His  Glu Cys Pro 
    1145                 1150                 1155             


His Ile  Pro Thr Pro Val Cys  Ile Gly His Arg Asp  Ala Pro Ser 
    1160                 1165                 1170             


Phe Ser  Ser Pro Pro Arg Gln  Ala Pro Glu Pro Ser  Leu Phe Phe 
    1175                 1180                 1185             


Gln Asp  Pro Pro Gly Thr Ser  Met Glu Ser Leu Ala  Pro Ser Thr 
    1190                 1195                 1200             


Asp Ser  Leu His Gly Ser Pro  Val Leu Ile Pro Gln  Val Cys Ile 
    1205                 1210                 1215             


Gly His  Arg Asp Ala Pro Arg  Ala Ser Ser Pro Pro  Arg His Pro 
    1220                 1225                 1230             


Pro Ser  Asp Leu Ala Phe Leu  Ala Pro Ser Pro Ser  Pro Gly Ser 
    1235                 1240                 1245             


Ser Gly  Gly Ser Arg Gly Ser  Ala Pro Pro Gly Glu  Thr Arg His 
    1250                 1255                 1260             


Asn Leu  Glu Arg Glu Glu Tyr  Thr Val Leu Ala Asp  Leu Pro Pro 
    1265                 1270                 1275             


Pro Arg  Arg Leu Ala Gln Arg  Gln Pro Gly Pro Gln  Ala Gln Cys 
    1280                 1285                 1290             


Ser Ser  Gly Gly Arg Thr His  Ser Pro Gly Arg Ala  Glu Val Glu 
    1295                 1300                 1305             


Arg Leu  Phe Gly Gln Glu Arg  Arg Lys Ser Glu Ala  Ala Gly Ala 
    1310                 1315                 1320             


Phe Gln  Ala Gln Asp Glu Gly  Arg Ser Gln Gln Pro  Ser Gln Gly 
    1325                 1330                 1335             


Gln Ser  Gln Leu Leu Arg Arg  Gln Ser Ser Pro Ala  Pro Ser Arg 
    1340                 1345                 1350             


Gln Val  Thr Met Leu Pro Ala  Lys Gln Ala Glu Leu  Thr Arg Arg 
    1355                 1360                 1365             


Ser Gln  Ala Glu Pro Pro His  Pro Trp Ser Pro Glu  Lys Arg Pro 
    1370                 1375                 1380             


Glu Gly  Asp Arg Gln Leu Gln  Gly Ser Pro Leu Pro  Pro Arg Thr 
    1385                 1390                 1395             


Ser Ala  Arg Thr Pro Glu Arg  Glu Leu Arg Thr Gln  Arg Pro Leu 
    1400                 1405                 1410             


Glu Ser  Gly Gln Ala Gly Pro  Arg Gln Pro Leu Gly  Val Trp Gln 
    1415                 1420                 1425             


Ser Gln  Glu Glu Pro Pro Gly  Ser Gln Gly Pro His  Arg His Leu 
    1430                 1435                 1440             


Glu Arg  Ser Trp Ser Ser Gln  Glu Gly Gly Leu Gly  Pro Gly Gly 
    1445                 1450                 1455             


Trp Trp  Gly Cys Gly Glu Pro  Ser Leu Gly Ala Ala  Lys Ala Pro 
    1460                 1465                 1470             


Glu Gly  Ala Trp Gly Gly Thr  Ser Arg Glu Tyr Lys  Glu Ser Trp 
    1475                 1480                 1485             


Gly Gln  Pro Glu Ala Trp Glu  Glu Lys Pro Thr His  Glu Leu Pro 
    1490                 1495                 1500             


Arg Glu  Leu Gly Lys Arg Ser  Pro Leu Thr Ser Pro  Pro Glu Asn 
    1505                 1510                 1515             


Trp Gly  Gly Pro Ala Glu Ser  Ser Gln Ser Trp His  Ser Gly Thr 
    1520                 1525                 1530             


Pro Thr  Ala Val Gly Trp Gly  Ala Glu Gly Ala Cys  Pro Tyr Pro 
    1535                 1540                 1545             


Arg Gly  Ser Glu Arg Arg Pro  Glu Leu Asp Trp Arg  Asp Leu Leu 
    1550                 1555                 1560             


Gly Leu  Leu Arg Ala Pro Gly  Glu Gly Val Trp Ala  Arg Val Pro 
    1565                 1570                 1575             


Ser Leu  Asp Trp Glu Gly Leu  Leu Glu Leu Leu Gln  Ala Arg Leu 
    1580                 1585                 1590             


Pro Arg  Lys Asp Pro Ala Gly  His Arg Asp Asp Leu  Ala Arg Ala 
    1595                 1600                 1605             


Leu Gly  Pro Glu Leu Gly Pro  Pro Gly Thr Asn Asp  Val Pro Glu 
    1610                 1615                 1620             


Gln Glu  Ser His Ser Gln Pro  Glu Gly Trp Ala Glu  Ala Thr Pro 
    1625                 1630                 1635             


Val Asn  Gly His Ser Pro Ala  Leu Gln Ser Gln Ser  Pro Val Gln 
    1640                 1645                 1650             


Leu Pro  Ser Pro Ala Cys Thr  Ser Thr Gln Trp Pro  Lys Ile Lys 
    1655                 1660                 1665             


Val Thr  Arg Gly Pro Ala Thr  Ala Thr Leu Ala Gly  Leu Glu Gln 
    1670                 1675                 1680             


Thr Gly  Pro Leu Gly Ser Arg  Ser Thr Ala Lys Gly  Pro Ser Leu 
    1685                 1690                 1695             


Pro Glu  Leu Gln Phe Gln Pro  Glu Glu Pro Glu Glu  Ser Glu Pro 
    1700                 1705                 1710             


Ser Arg  Gly Gln Asp Pro Leu  Thr Asp Gln Lys Gln  Ala Asp Ser 
    1715                 1720                 1725             


Ala Asp  Lys Arg Pro Ala Glu  Gly Lys Ala Gly Ser  Pro Leu Lys 
    1730                 1735                 1740             


Gly Arg  Leu Val Thr Ser Trp  Arg Met Pro Gly Asp  Arg Pro Thr 
    1745                 1750                 1755             


Leu Phe  Asn Pro Phe Leu Leu  Ser Leu Gly Val Leu  Arg Trp Arg 
    1760                 1765                 1770             


Arg Pro  Asp Leu Leu Asn Phe  Lys Lys Gly Trp Met  Ser Ile Leu 
    1775                 1780                 1785             


Asp Glu  Pro Gly Glu Pro Pro  Ser Pro Ser Leu Thr  Thr Thr Ser 
    1790                 1795                 1800             


Thr Ser  Gln Trp Lys Lys His  Trp Phe Val Leu Thr  Asp Ser Ser 
    1805                 1810                 1815             


Leu Lys  Tyr Tyr Arg Asp Ser  Thr Ala Glu Glu Ala  Asp Glu Leu 
    1820                 1825                 1830             


Asp Gly  Glu Ile Asp Leu Arg  Ser Cys Thr Asp Val  Thr Glu Tyr 
    1835                 1840                 1845             


Ala Val  Gln Arg Asn Tyr Gly  Phe Gln Ile His Thr  Lys Asp Ala 
    1850                 1855                 1860             


Val Tyr  Thr Leu Ser Ala Met  Thr Ser Gly Ile Arg  Arg Asn Trp 
    1865                 1870                 1875             


Ile Glu  Ala Leu Arg Lys Thr  Val Arg Pro Thr Ser  Ala Pro Asp 
    1880                 1885                 1890             


Val Thr  Lys Leu Ser Asp Ser  Asn Lys Glu Asn Ala  Leu His Ser 
    1895                 1900                 1905             


Tyr Ser  Thr Gln Lys Gly Pro  Leu Lys Ala Gly Glu  Gln Arg Ala 
    1910                 1915                 1920             


Gly Ser  Glu Val Ile Ser Arg  Gly Gly Pro Arg Lys  Ala Asp Gly 
    1925                 1930                 1935             


Gln Arg  Gln Ala Leu Asp Tyr  Val Glu Leu Ser Pro  Leu Thr Gln 
    1940                 1945                 1950             


Ala Ser  Pro Gln Arg Ala Arg  Thr Pro Ala Arg Thr  Pro Asp Arg 
    1955                 1960                 1965             


Leu Ala  Lys Gln Glu Glu Leu  Glu Arg Asp Leu Ala  Gln Arg Ser 
    1970                 1975                 1980             


Glu Glu  Arg Arg Lys Trp Phe  Glu Ala Thr Asp Ser  Arg Thr Pro 
    1985                 1990                 1995             


Glu Val  Pro Ala Gly Glu Gly  Pro Arg Arg Gly Leu  Gly Ala Pro 
    2000                 2005                 2010             


Leu Thr  Glu Asp Gln Gln Asn  Arg Leu Ser Glu Glu  Ile Glu Lys 
    2015                 2020                 2025             


Lys Trp  Gln Glu Leu Glu Lys  Leu Pro Leu Arg Glu  Asn Lys Arg 
    2030                 2035                 2040             


Val Pro  Leu Thr Ala Leu Leu  Asn Gln Ser Arg Gly  Glu Arg Arg 
    2045                 2050                 2055             


Gly Pro  Pro Ser Asp Gly His  Glu Ala Leu Glu Lys  Glu Val Gln 
    2060                 2065                 2070             


Ala Leu  Arg Ala Gln Leu Glu  Ala Trp Arg Leu Gln  Gly Glu Ala 
    2075                 2080                 2085             


Pro Gln  Ser Ala Leu Arg Ser  Gln Glu Asp Gly His  Ile Pro Pro 
    2090                 2095                 2100             


Gly Tyr  Ile Ser Gln Glu Ala  Cys Glu Arg Ser Leu  Ala Glu Met 
    2105                 2110                 2115             


Glu Ser  Ser His Gln Gln Val  Met Glu Glu Leu Gln  Arg His His 
    2120                 2125                 2130             


Glu Arg  Glu Leu Gln Arg Leu  Gln Gln Glu Lys Glu  Trp Leu Leu 
    2135                 2140                 2145             


Ala Glu  Glu Thr Ala Ala Thr  Ala Ser Ala Ile Glu  Ala Met Lys 
    2150                 2155                 2160             


Lys Ala  Tyr Gln Glu Glu Leu  Ser Arg Glu Leu Ser  Lys Thr Arg 
    2165                 2170                 2175             


Ser Leu  Gln Gln Gly Pro Asp  Gly Leu Arg Lys Gln  His Gln Ser 
    2180                 2185                 2190             


Asp Val  Glu Ala Leu Lys Arg  Glu Leu Gln Val Leu  Ser Glu Gln 
    2195                 2200                 2205             


Tyr Ser  Gln Lys Cys Leu Glu  Ile Gly Ala Leu Met  Arg Gln Ala 
    2210                 2215                 2220             


Glu Glu  Arg Glu His Thr Leu  Arg Arg Cys Gln Gln  Glu Gly Gln 
    2225                 2230                 2235             


Glu Leu  Leu Arg His Asn Gln  Glu Leu His Gly Arg  Leu Ser Glu 
    2240                 2245                 2250             


Glu Ile  Asp Gln Leu Arg Gly  Phe Ile Ala Ser Gln  Gly Met Gly 
    2255                 2260                 2265             


Asn Gly  Cys Gly Arg Ser Asn  Glu Arg Ser Ser Cys  Glu Leu Glu 
    2270                 2275                 2280             


Val Leu  Leu Arg Val Lys Glu  Asn Glu Leu Gln Tyr  Leu Lys Lys 
    2285                 2290                 2295             


Glu Val  Gln Cys Leu Arg Asp  Glu Leu Gln Met Met  Gln Lys Asp 
    2300                 2305                 2310             


Lys Arg  Phe Thr Ser Gly Lys  Tyr Gln Asp Val Tyr  Val Glu Leu 
    2315                 2320                 2325             


Ser His  Ile Lys Thr Arg Ser  Glu Arg Glu Ile Glu  Gln Leu Lys 
    2330                 2335                 2340             


Glu His  Leu Arg Leu Ala Met  Ala Ala Leu Gln Glu  Lys Glu Ser 
    2345                 2350                 2355             


Met Arg  Asn Ser Leu Ala Glu  
    2360                 2365 


<210>  27
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  28
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  29
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  30
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
        35                  40                  45              


Gly Ile Asn Leu Asp Leu Gly Ser Gly Val Lys Val Lys Ile Ile Pro 
    50                  55                  60                  


Lys Glu Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln 
65                  70                  75                  80  


Val 
    


