			REPLACEMENT SHEETS
                  Serial No. PCT/US2015/029795                         


			SEQUENCE LISTING

<110>  APPLIED MOLECULAR TRANSPORT LLC
 
<120>  CHOLIX TOXIN-DERIVED FUSION MOLECULES FOR ORAL DELIVERY OF 
       BIOLOGICALLY ACTIVE CARGO

<130>  CACAM1.0002WO

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  634
<212>  PRT
<213>  Vibreo cholerae 

<400>  1

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210>  2
<211>  1905
<212>  DNA
<213>  Vibreo cholerae

<400>  2

atggtcgaag aagctttaaa catctttgat gaatgccgtt cgccatgttc gttgaccccg       60

gaaccgggta agccgattca atcaaaactg tctatcccta gtgatgttgt tctggatgaa      120

ggtgttctgt attactcgat gacgattaat gatgagcaga atgatattaa ggatgaggac      180

aaaggcgagt ccattatcac tattggtgaa tttgccacag tacgcgcgac tagacattat      240

gttaatcaag atgcgccttt tggtgtcatc catttagata ttacgacaga aaatggtaca      300

aaaacgtact cttataaccg caaagagggt gaatttgcaa tcaattggtt agtgcctatt      360

ggtgaagatt ctcctgcaag catcaaaatc tccgttgatg agctcgatca gcaacgcaat      420

atcatcgagg tgcctaaact gtatagtatt gatctcgata accaaacgtt agagcagtgg      480

aaaacccaag gtaatgtttc tttttcggta acgcgtcctg aacataatat cgctatctct      540

tggccaagcg tgagttacaa agcagcgcag aaagagggtt cacgccataa gcgttgggct      600

cattggcata caggcttagc actgtgttgg cttgtgccaa tggatgctat ctataactat      660

atcacccagc aaaattgtac tttaggggat aattggtttg gtggctctta tgagactgtt      720

gcaggcactc cgaaggtgat tacggttaag caagggattg aacaaaagcc agttgagcag      780

cgcatccatt tctccaaggg gaatgcgatg agcgcacttg ctgctcatcg cgtctgtggt      840

gtgccattag aaactttggc gcgcagtcgc aaacctcgtg atctgacgga tgatttatca      900

tgtgcctatc aagcgcagaa tatcgtgagt ttatttgtcg cgacgcgtat cctgttctct      960

catctggata gcgtatttac tctgaatctt gacgaacaag aaccagaggt ggctgaacgt     1020

ctaagtgatc ttcgccgtat caatgaaaat aacccgggca tggttacaca ggttttaacc     1080

gttgctcgtc agatctataa cgattatgtc actcaccatc cgggcttaac tcctgagcaa     1140

accagtgcgg gtgcacaagc tgccgatatc ctctctttat tttgcccaga tgctgataag     1200

tcttgtgtgg cttcaaacaa cgatcaagcc aatatcaaca tcgagtctcg ttctggccgt     1260

tcatatttgc ctgaaaaccg tgcggtaatc acccctcaag gcgtcacaaa ttggacttac     1320

caggaactcg aagcaacaca tcaagctctg actcgtgagg gttatgtgtt cgtgggttac     1380

catggtacga atcatgtcgc tgcgcaaacc atcgtgaatc gcattgcccc tgttccgcgc     1440

ggcaacaaca ctgaaaacga ggaaaagtgg ggcgggttat atgttgcaac tcacgctgaa     1500

gttgcccatg gttatgctcg catcaaagaa gggacagggg agtatggcct tccgacccgt     1560

gctgagcgcg acgctcgtgg ggtaatgctg cgcgtgtata tccctcgtgc ttcattagaa     1620

cgtttttatc gcacgaatac acctttggaa aatgctgagg agcatatcac gcaagtgatt     1680

ggtcattctt tgccattacg caatgaagca tttactggtc cagaaagtgc gggcggggaa     1740

gacgaaactg tcattggctg ggatatggcg attcatgcag ttgcgatccc ttcgactatc     1800

ccagggaacg cttacgaaga attggcgatt gatgaggagg ctgttgcaaa agagcaatcg     1860

attagcacaa aaccacctta taaagagcgc aaagatgaac ttaag                     1905


<210>  3
<211>  386
<212>  PRT
<213>  Vibreo cholerae

<400>  3

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala 
385     


<210>  4
<211>  385
<212>  PRT
<213>  Vibreo cholerae

<400>  4

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln 
385 


<210>  5
<211>  384
<212>  PRT
<213>  Vibreo cholerae

<400>  5

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


<210>  6
<211>  383
<212>  PRT
<213>  Vibreo cholerae

<400>  6

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380             


<210>  7
<211>  382
<212>  PRT
<213>  Vibreo cholerae

<400>  7

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
    370                 375                 380         


<210>  8
<211>  381
<212>  PRT
<213>  Vibreo cholerae

<400>  8

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser 
    370                 375                 380     


<210>  9
<211>  380
<212>  PRT
<213>  Vibreo cholerae

<400>  9

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr 
    370                 375                 380 


<210>  10
<211>  379
<212>  PRT
<213>  Vibreo cholerae

<400>  10

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln 
    370                 375                 


<210>  11
<211>  378
<212>  PRT
<213>  Vibreo cholerae

<400>  11

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu 
    370                 375             


<210>  12
<211>  377
<212>  PRT
<213>  Vibreo cholerae

<400>  12

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro 
    370                 375         


<210>  13
<211>  376
<212>  PRT
<213>  Vibreo cholerae

<400>  13

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr 
    370                 375     


<210>  14
<211>  375
<212>  PRT
<213>  Vibreo cholerae

<400>  14

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu 
    370                 375 


<210>  15
<211>  374
<212>  PRT
<213>  Vibreo cholerae

<400>  15

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly 
    370                 


<210>  16
<211>  373
<212>  PRT
<213>  Vibreo cholerae

<400>  16

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro 
    370             


<210>  17
<211>  372
<212>  PRT
<213>  Vibreo cholerae

<400>  17

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His 
    370         


<210>  18
<211>  371
<212>  PRT
<213>  Vibreo cholerae

<400>  18

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His 
    370     


<210>  19
<211>  370
<212>  PRT
<213>  Vibreo cholerae

<400>  19

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr 
    370 


<210>  20
<211>  369
<212>  PRT
<213>  Vibreo cholerae

<400>  20

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val 
    


<210>  21
<211>  368
<212>  PRT
<213>  Vibreo cholerae

<400>  21

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


<210>  22
<211>  367
<212>  PRT
<213>  Vibreo cholerae

<400>  22

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365         


<210>  23
<211>  366
<212>  PRT
<213>  Vibreo cholerae

<400>  23

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
        355                 360                 365     


<210>  24
<211>  365
<212>  PRT
<213>  Vibreo cholerae

<400>  24

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr 
        355                 360                 365 


<210>  25
<211>  364
<212>  PRT
<213>  Vibreo cholerae

<400>  25

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile 
        355                 360                 


<210>  26
<211>  363
<212>  PRT
<213>  Vibreo cholerae

<400>  26

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln 
        355                 360             


<210>  27
<211>  362
<212>  PRT
<213>  Vibreo cholerae

<400>  27

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg 
        355                 360         


<210>  28
<211>  361
<212>  PRT
<213>  Vibreo cholerae

<400>  28

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala 
        355                 360     


<210>  29
<211>  360
<212>  PRT
<213>  Vibreo cholerae

<400>  29

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val 
        355                 360 


<210>  30
<211>  359
<212>  PRT
<213>  Vibreo cholerae

<400>  30

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr 
        355                 


<210>  31
<211>  358
<212>  PRT
<213>  Vibreo cholerae

<400>  31

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu 
        355             


<210>  32
<211>  357
<212>  PRT
<213>  Vibreo cholerae

<400>  32

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val 
        355         


<210>  33
<211>  356
<212>  PRT
<213>  Vibreo cholerae

<400>  33

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln 
        355     


<210>  34
<211>  355
<212>  PRT
<213>  Vibreo cholerae

<400>  34

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr 
        355 


<210>  35
<211>  354
<212>  PRT
<213>  Vibreo cholerae

<400>  35

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val 
        


<210>  36
<211>  353
<212>  PRT
<213>  Vibreo cholerae

<400>  36

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met 
    


<210>  37
<211>  352
<212>  PRT
<213>  Vibreo cholerae

<400>  37

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


<210>  38
<211>  351
<212>  PRT
<213>  Vibreo cholerae

<400>  38

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350     


<210>  39
<211>  350
<212>  PRT
<213>  Vibreo cholerae

<400>  39

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn 
            340                 345                 350 


<210>  40
<211>  349
<212>  PRT
<213>  Vibreo cholerae

<400>  40

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn 
            340                 345                 


<210>  41
<211>  348
<212>  PRT
<213>  Vibreo cholerae

<400>  41

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu 
            340                 345             


<210>  42
<211>  425
<212>  PRT
<213>  Vibreo cholerae

<400>  42

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn 
            420                 425 


<210>  43
<211>  424
<212>  PRT
<213>  Vibreo cholerae

<400>  43

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu 
            420                 


<210>  44
<211>  423
<212>  PRT
<213>  Vibreo cholerae

<400>  44

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro 
            420             


<210>  45
<211>  422
<212>  PRT
<213>  Vibreo cholerae

<400>  45

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu 
            420         


<210>  46
<211>  421
<212>  PRT
<213>  Vibreo cholerae

<400>  46

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr 
            420     


<210>  47
<211>  420
<212>  PRT
<213>  Vibreo cholerae

<400>  47

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser 
            420 


<210>  48
<211>  419
<212>  PRT
<213>  Vibreo cholerae

<400>  48

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg 
            


<210>  49
<211>  418
<212>  PRT
<213>  Vibreo cholerae

<400>  49

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly 
        


<210>  50
<211>  417
<212>  PRT
<213>  Vibreo cholerae

<400>  50

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser 
    


<210>  51
<211>  416
<212>  PRT
<213>  Vibreo cholerae

<400>  51

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


<210>  52
<211>  415
<212>  PRT
<213>  Vibreo cholerae

<400>  52

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser 
                405                 410                 415 


<210>  53
<211>  414
<212>  PRT
<213>  Vibreo cholerae

<400>  53

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
                405                 410                 


<210>  54
<211>  413
<212>  PRT
<213>  Vibreo cholerae

<400>  54

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile 
                405                 410             


<210>  55
<211>  412
<212>  PRT
<213>  Vibreo cholerae

<400>  55

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn 
                405                 410         


<210>  56
<211>  411
<212>  PRT
<213>  Vibreo cholerae

<400>  56

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile 
                405                 410     


<210>  57
<211>  410
<212>  PRT
<213>  Vibreo cholerae

<400>  57

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn 
                405                 410 


<210>  58
<211>  409
<212>  PRT
<213>  Vibreo cholerae

<400>  58

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala 
                405                 


<210>  59
<211>  408
<212>  PRT
<213>  Vibreo cholerae

<400>  59

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln 
                405             


<210>  60
<211>  407
<212>  PRT
<213>  Vibreo cholerae

<400>  60

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp 
                405         


<210>  61
<211>  406
<212>  PRT
<213>  Vibreo cholerae

<400>  61

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn 
                405     


<210>  62
<211>  405
<212>  PRT
<213>  Vibreo cholerae

<400>  62

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn 
                405 


<210>  63
<211>  404
<212>  PRT
<213>  Vibreo cholerae

<400>  63

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser 
                


<210>  64
<211>  403
<212>  PRT
<213>  Vibreo cholerae

<400>  64

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala 
            


<210>  65
<211>  402
<212>  PRT
<213>  Vibreo cholerae

<400>  65

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val 
        


<210>  66
<211>  401
<212>  PRT
<213>  Vibreo cholerae

<400>  66

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys 
    


<210>  67
<211>  400
<212>  PRT
<213>  Vibreo cholerae

<400>  67

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


<210>  68
<211>  399
<212>  PRT
<213>  Vibreo cholerae

<400>  68

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys 
385                 390                 395                 


<210>  69
<211>  398
<212>  PRT
<213>  Vibreo cholerae

<400>  69

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
385                 390                 395             


<210>  70
<211>  397
<212>  PRT
<213>  Vibreo cholerae

<400>  70

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala 
385                 390                 395         


<210>  71
<211>  396
<212>  PRT
<213>  Vibreo cholerae

<400>  71

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp 
385                 390                 395     


<210>  72
<211>  395
<212>  PRT
<213>  Vibreo cholerae

<400>  72

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro 
385                 390                 395 


<210>  73
<211>  394
<212>  PRT
<213>  Vibreo cholerae

<400>  73

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys 
385                 390                 


<210>  74
<211>  393
<212>  PRT
<213>  Vibreo cholerae

<400>  74

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe 
385                 390             


<210>  75
<211>  392
<212>  PRT
<213>  Vibreo cholerae

<400>  75

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu 
385                 390         


<210>  76
<211>  391
<212>  PRT
<213>  Vibreo cholerae

<400>  76

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser 
385                 390     


<210>  77
<211>  390
<212>  PRT
<213>  Vibreo cholerae

<400>  77

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu 
385                 390 


<210>  78
<211>  389
<212>  PRT
<213>  Vibreo cholerae

<400>  78

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile 
385                 


<210>  79
<211>  388
<212>  PRT
<213>  Vibreo cholerae

<400>  79

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp 
385             


<210>  80
<211>  387
<212>  PRT
<213>  Vibreo cholerae

<400>  80

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala 
385         


<210>  81
<211>  633
<212>  PRT
<213>  Vibreo cholerae 

<220>
<223>	mature Cholix Toxin deleted at amio acid residue 581

<400>  81

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val 
            580                 585                 590         


Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile 
        595                 600                 605             


Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630             


<210>  82
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  82

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  83
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Ser Ser 
                165                 170                 175     


Ala 
    


<210>  84
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  85
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  86
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr 
            100                 105                 110         


Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg 
        115                 120                 125             


Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn 
    130                 135                 140                 


Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met 
145                 150                 155                 160 


Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg 
                165                 170                 175     


Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly 
            180                 185                 190         


Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205         


<210>  87
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Leu Val Asn Phe Ile Leu Arg Cys Gly Leu Leu Leu Val Thr Leu 
1               5                   10                  15      


Ser Leu Ala Ile Ala Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys 
            20                  25                  30          


Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys 
        35                  40                  45              


Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile 
    50                  55                  60                  


Arg Leu Leu Lys Lys Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln 
65                  70                  75                  80  


Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln 
                85                  90                  95      


Leu Gln Leu Gln Gly Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His 
            100                 105                 110         


Ser Leu Arg Gln Lys Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala 
        115                 120                 125             


Arg Glu Met Lys Ser Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile 
    130                 135                 140                 


Gly Asn Lys Gly Ile Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu 
145                 150                 155                 160 


Ser Trp Ile Lys Lys Leu Leu Glu Ser Ser Gln 
                165                 170     


<210>  88
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence for an anti-TNF-alpha 
       antibody

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Arg Gly Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  89
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence for an anti-TNF-alpha 
       antibody

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  90
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence for an anti-TNF-alpha 
       antibody

<400>  90

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Phe Asp Gly Ser Asn Lys Ser Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Tyr Ser Arg Arg Asn Ser Lys Asn Ala Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Ser Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  91
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence for an anti-TNF-alpha 
       antibody

<400>  91

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Leu 
            100                 105             


<210>  92
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human TNFR-p75-Fc dimeric fusion protein

<400>  92

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  93
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1 agonist peptide amino acid sequence (exenatide)

<400>  93

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  94
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 agonist peptide amino acid sequence (Liraglutide)

<400>  94

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Glu Phe Ile Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30          


Gly 
    


<210>  95
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human growth hormone (somatotropin)

<400>  95

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  96

Gly Gly Gly Gly Ser 
1               5   


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  97

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  98
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  98

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  99

Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210>  100
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  100

Ala Ala Pro Phe 
1               


<210>  101
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  101

Gly Gly Phe 
1           


<210>  102
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  102

Ala Ala Pro Val 
1               


<210>  103
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  103

Gly Gly Leu 
1           


<210>  104
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  104

Ala Ala Leu 
1           


<210>  105
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  105

Phe Val Arg 
1           


<210>  106
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  106

Val Gly Arg 
1           


<210>  107
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  107

Arg Lys Pro Arg 
1               


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>	Peptide
<220>
<221>  	Variant
<222>	5
<223>  	Xaa = Any Amino Acid

<400>  108

Tyr Val Ala Asp Xaa 
1               5   


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>	Peptide    
<220>
<221>  	Variant
<222>  	2, 3, 5
<223>  	Xaa = Any Amino Acid

<400>  109

Asp Xaa Xaa Asp Xaa 
1               5   


<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide
<220>
<221>  Variant
<222>  2, 5
<223>  Xaa = Any Amino Acid

<400>  110

Arg Xaa Asn Arg Xaa 
1               5   


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide    
<220>
<221>  Variant
<222>  2, 5
<223>  Xaa = Any Amino Acid

<400>  111

Lys Xaa Asn Arg Xaa 
1               5   


<210>  112
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide   
<220>
<221>  Variant
<222>  6
<223>  Xaa = Any Amino Acid

<400>  112

Glu Arg Thr Lys Arg Xaa 
1               5       


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 
<220>
<221>  Variant
<222>  5
<223>  Xaa = Any Amino Acid

<400>  113

Arg Val Arg Arg Xaa 
1               5   


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide       
<220>
<221>  Variant
<222>  6
<223>  Xaa = Any Amino Acid

<400>  114

Asp Arg Val Arg Arg Xaa 
1               5       


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide     
<220>
<221>  Variant
<222>  2, 6
<223>  Xaa = Any Amino Acid

<400>  115

Pro Xaa Trp Val Pro Xaa 
1               5       


<210>  116
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 
<220>
<221>  Variant
<222>  4
<223>  Xaa = Any Amino Acid

<400>  116

Trp Val Ala Xaa 
1               


<210>  117
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide        
<220>
<221>  Variant
<222>  1, 3, 4
<223>  Xaa = Any Amino Acid

<400>  117

Xaa Phe Xaa Xaa 
1               


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide     
<220>
<221>  Variant
<222>  1, 3, 4
<223>  Xaa = Any Amino Acid

<400>  118

Xaa Tyr Xaa Xaa 
1               


<210>  119
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide
<220>
<221>  Variant
<222>  1, 3, 4
<223>  Xaa = Any Amino Acid

<400>  119

Xaa Trp Xaa Xaa 
1               


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  120

Asp Arg Tyr Ile Pro Phe His Leu Leu Val Ala Pro Tyr Ser Pro Ala 
1               5                   10                  15      


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  121

Gly Gly Gly Gly Ser Gly Gly Gly Glu Asn Leu Tyr Phe Gln Ser 
1               5                   10                  15  


<210>  122
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a Cholix415-TEV-IL-10 fusion molecule

<400>  122

Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn 
    290                 295                 300                 


Ala Gln Gln Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr 
305                 310                 315                 320 


His Ile Asp Ser Ile Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Ile Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys 
385                 390                 395                 400 


Ser Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Glu Asn Leu Tyr Phe Gln Ser Pro 
            420                 425                 430         


Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly Asn 
        435                 440                 445             


Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
    450                 455                 460                 


Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
                485                 490                 495     


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
            500                 505                 510         


Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn Leu 
        515                 520                 525             


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
    530                 535                 540                 


Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn Lys 
545                 550                 555                 560 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
                565                 570                 575     


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
            580                 585                 590 


<210>  123
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of a Cholix415-(G4S)3-IL-10 fusion molecule

<400>  123

Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn 
    290                 295                 300                 


Ala Gln Gln Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr 
305                 310                 315                 320 


His Ile Asp Ser Ile Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Ile Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys 
385                 390                 395                 400 


Ser Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
            420                 425                 430         


Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly Asn 
        435                 440                 445             


Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys 
    450                 455                 460                 


Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser 
                485                 490                 495     


Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn 
            500                 505                 510         


Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn Leu 
        515                 520                 525             


Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys 
    530                 535                 540                 


Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn Lys 
545                 550                 555                 560 


Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile Phe 
                565                 570                 575     


Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
            580                 585                 590 


