                               SEQUENCE LISTING

<110> BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> COORDINATE CONTROL OF PATHOGENIC SIGNALING BY THE MIR-130/301 
      FAMILY IN PULMONARY HYPERTENSION AND FIBROPROLIFERATIVE DISEASES

<130> 043214-081281-PCT

<140> PCT/US2015/029286
<141> 2015-05-05

<150> 61/988,550
<151> 2014-05-05

<160> 65    

<170> PatentIn version 3.5

<210> 1
<211> 7
<212> RNA
<213> Homo sapiens

<400> 1
agugcaa                                                                  7


<210> 2
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ttgcact                                                                  7


<210> 3
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
attgcact                                                                 8


<210> 4
<211> 22
<212> RNA
<213> Homo sapiens

<400> 4
cagugcaaug uuaaaagggc au                                                22


<210> 5
<211> 22
<212> RNA
<213> Homo sapiens

<400> 5
cagugcaaug augaaagggc au                                                22


<210> 6
<211> 23
<212> RNA
<213> Homo sapiens

<400> 6
cagugcaaua guauugucaa agc                                               23


<210> 7
<211> 23
<212> RNA
<213> Homo sapiens

<400> 7
cagugcaaug auauugucaa agc                                               23


<210> 8
<211> 8
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 3'UTR of PPARG highly conserved
      putative binding site oligonucleotide

<400> 8
uugcacua                                                                 8


<210> 9
<211> 25
<212> RNA
<213> Homo sapiens

<400> 9
cccuucuucc aguugcacua uucug                                             25


<210> 10
<211> 28
<212> RNA
<213> Mus musculus

<400> 10
uccuucuauu gauugcacua uuauuuug                                          28


<210> 11
<211> 28
<212> RNA
<213> Rattus norvegicus

<400> 11
uccuucuauc gauugcacua uuauuuug                                          28


<210> 12
<211> 28
<212> RNA
<213> Dasypus novemcinctus

<400> 12
uccuccuccc aguugcacua uuauuuug                                          28


<210> 13
<211> 28
<212> RNA
<213> Xenopus tropicalis

<400> 13
acucgccccc auuugcacua uuucuaua                                          28


<210> 14
<211> 22
<212> RNA
<213> Homo sapiens

<400> 14
cagugcaaug uuaaaagggc au                                                22


<210> 15
<211> 7
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 3' UTR of TIMP2 highly conserved
      putative binding site oligonucleotide

<400> 15
uugcacu                                                                  7


<210> 16
<211> 29
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      TIMP2 oligonucleotide

<400> 16
acccuuggua gguauuagac uugcacuuu                                         29


<210> 17
<211> 29
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      TIMP2 oligonucleotide

<400> 17
gccuuucgua gcauuagacu uugcacuuu                                         29


<210> 18
<211> 29
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      TIMP2 oligonucleotide

<400> 18
gccuuuugua gcauuagacu uugcacuuu                                         29


<210> 19
<211> 29
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      TIMP2 oligonucleotide

<400> 19
ucccccggua gcuguuagac uugcacuuu                                         29


<210> 20
<211> 89
<212> RNA
<213> Homo sapiens

<400> 20
ugcugcuggc cagagcucuu uucacauugu gcuacugucu gcaccuguca cuagcagugc       60

aauguuaaaa gggcauuggc cguguagug                                         89


<210> 21
<211> 82
<212> RNA
<213> Homo sapiens

<400> 21
ggccugcccg acacucuuuc ccuguugcac uacuauaggc cgcugggaag cagugcaaug       60

augaaagggc aucggucagg uc                                                82


<210> 22
<211> 86
<212> RNA
<213> Homo sapiens

<400> 22
acugcuaacg aaugcucuga cuuuauugca cuacuguacu uuacagcuag cagugcaaua       60

guauugucaa agcaucugaa agcagg                                            86


<210> 23
<211> 78
<212> RNA
<213> Homo sapiens

<400> 23
gccgcaggug cucugacgag guugcacuac ugugcucuga gaagcagugc aaugauauug       60

ucaaagcauc ugggacca                                                     78


<210> 24
<211> 64
<212> RNA
<213> Mus musculus

<400> 24
gagcucuuuu cacauugugc uacugucuaa cguguaccga gcagugcaau guuaaaaggg       60

cauc                                                                    64


<210> 25
<211> 82
<212> RNA
<213> Mus musculus

<400> 25
ggcuuguugg acacucuuuc ccuguugcac uacugugggc cucugggaag cagugcaaug       60

augaaagggc aucugucggg cc                                                82


<210> 26
<211> 23
<212> RNA
<213> Homo sapiens

<400> 26
uagugcaaua uugcuuauag ggu                                               23


<210> 27
<211> 115
<212> RNA
<213> Homo sapiens

<400> 27
ucuguuuauc accagauccu agaacccuau caauauuguc ucugcugugu aaauaguucu       60

gaguagugca auauugcuua uaggguuuug guguuuggaa agaacaaugg gcagg           115


<210> 28
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 29
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 31
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 32
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 33
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210> 34
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210> 35
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 36
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 37
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine 

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Norleucine 

<400> 37
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Xaa Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Xaa Ile Asp Gly 
        35                  40      


<210> 38
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210> 39
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210> 40
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210> 41
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 42
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210> 43
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
His His His His His Trp Tyr Gly 
1               5               


<210> 45
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Cys His Lys Lys Lys Lys Lys Lys His Cys
1               5                   10               


<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 47
<211> 14
<212> PRT
<213> Human immunodeficiency virus

<400> 47
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210> 48
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 49
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 50
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 51
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
tcatacta                                                                 8


<210> 52
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
ccactccc                                                                 8


<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 54
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
ttctcctaat                                                              10


<210> 55
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 56
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 57
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 58
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 59
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 60
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 61
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 62
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 63
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 65
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


