                         SEQUENCE LISTING

<110>  Conagen, Inc.
       Mao, Guohong
       Chaturvedula, Venkata Sai Prakash
       Yu, Oiver
 
<120>  A NON-CALORIC SWEETENER

<130>  32559-11

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Asp Ser Gly Tyr Ser Ser Ser Tyr Ala Ala Ala Ala Gly Met His 
1               5                   10                  15      


Val Val Ile Cys Pro Trp Leu Ala Phe Gly His Leu Leu Pro Cys Leu 
            20                  25                  30          


Asp Leu Ala Gln Arg Leu Ala Ser Arg Gly His Arg Val Ser Phe Val 
        35                  40                  45              


Ser Thr Pro Arg Asn Ile Ser Arg Leu Pro Pro Val Arg Pro Ala Leu 
    50                  55                  60                  


Ala Pro Leu Val Ala Phe Val Ala Leu Pro Leu Pro Arg Val Glu Gly 
65                  70                  75                  80  


Leu Pro Asp Gly Ala Glu Ser Thr Asn Asp Val Pro His Asp Arg Pro 
                85                  90                  95      


Asp Met Val Glu Leu His Arg Arg Ala Phe Asp Gly Leu Ala Ala Pro 
            100                 105                 110         


Phe Ser Glu Phe Leu Gly Thr Ala Cys Ala Asp Trp Val Ile Val Asp 
        115                 120                 125             


Val Phe His His Trp Ala Ala Ala Ala Ala Leu Glu His Lys Val Pro 
    130                 135                 140                 


Cys Ala Met Met Leu Leu Gly Ser Ala His Met Ile Ala Ser Ile Ala 
145                 150                 155                 160 


Asp Arg Arg Leu Glu Arg Ala Glu Thr Glu Ser Pro Ala Ala Ala Gly 
                165                 170                 175     


Gln Gly Arg Pro Ala Ala Ala Pro Thr Phe Glu Val Ala Arg Met Lys 
            180                 185                 190         


Leu Ile Arg Thr Lys Gly Ser Ser Gly Met Ser Leu Ala Glu Arg Phe 
        195                 200                 205             


Ser Leu Thr Leu Ser Arg Ser Ser Leu Val Val Gly Arg Ser Cys Val 
    210                 215                 220                 


Glu Phe Glu Pro Glu Thr Val Pro Leu Leu Ser Thr Leu Arg Gly Lys 
225                 230                 235                 240 


Pro Ile Thr Phe Leu Gly Leu Met Pro Pro Leu His Glu Gly Arg Arg 
                245                 250                 255     


Glu Asp Gly Glu Asp Ala Thr Val Arg Trp Leu Asp Ala Gln Pro Ala 
            260                 265                 270         


Lys Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Pro Leu Gly Val 
        275                 280                 285             


Glu Lys Val His Glu Leu Ala Leu Gly Leu Glu Leu Ala Gly Thr Arg 
    290                 295                 300                 


Phe Leu Trp Ala Leu Arg Lys Pro Thr Gly Val Ser Asp Ala Asp Leu 
305                 310                 315                 320 


Leu Pro Ala Gly Phe Glu Glu Arg Thr Arg Gly Arg Gly Val Val Ala 
                325                 330                 335     


Thr Arg Trp Val Pro Gln Met Ser Ile Leu Ala His Ala Ala Val Gly 
            340                 345                 350         


Ala Phe Leu Thr His Cys Gly Trp Asn Ser Thr Ile Glu Gly Leu Met 
        355                 360                 365             


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly Asp Gln Gly Pro 
    370                 375                 380                 


Asn Ala Arg Leu Ile Glu Ala Lys Asn Ala Gly Leu Gln Val Ala Arg 
385                 390                 395                 400 


Asn Asp Gly Asp Gly Ser Phe Asp Arg Glu Gly Val Ala Ala Ala Ile 
                405                 410                 415     


Arg Ala Val Ala Val Glu Glu Glu Ser Ser Lys Val Phe Gln Ala Lys 
            420                 425                 430         


Ala Lys Lys Leu Gln Glu Ile Val Ala Asp Met Ala Cys His Glu Arg 
        435                 440                 445             


Tyr Ile Asp Gly Phe Ile Gln Gln Leu Arg Ser Tyr Lys Asp 
    450                 455                 460         


<210>  2
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atggattcgg gttactcttc ctcctatgcg gcggctgcgg gtatgcacgt tgttatctgt       60

ccgtggctgg cttttggtca cctgctgccg tgcctggatc tggcacagcg tctggcttca      120

cgcggccatc gtgtcagctt cgtgtctacc ccgcgcaata tttcgcgtct gccgccggtt      180

cgtccggcac tggctccgct ggttgcattt gtcgctctgc cgctgccgcg cgtggaaggt      240

ctgccggatg gtgcggaaag taccaacgac gtgccgcatg atcgcccgga catggttgaa      300

ctgcaccgtc gtgcattcga tggtctggca gcaccgtttt ccgaatttct gggtacggcg      360

tgcgccgatt gggtgatcgt tgacgtcttt catcactggg cggcggcggc ggcgctggaa      420

cataaagttc cgtgtgcaat gatgctgctg ggctcagctc acatgattgc gtcgatcgca      480

gaccgtcgcc tggaacgtgc agaaaccgaa agtccggctg cggccggcca gggtcgcccg      540

gcagctgcgc cgaccttcga agtggcccgc atgaaactga ttcgtacgaa aggcagctct      600

ggtatgagcc tggcagaacg ctttagtctg accctgtccc gtagttccct ggtggttggt      660

cgcagttgcg ttgaatttga accggaaacc gtcccgctgc tgtccacgct gcgtggtaaa      720

ccgatcacct ttctgggtct gatgccgccg ctgcatgaag gccgtcgcga agatggtgaa      780

gacgcaacgg tgcgttggct ggatgcacag ccggctaaaa gcgtcgtgta tgtcgccctg      840

ggctctgaag tgccgctggg tgtggaaaaa gttcacgaac tggcactggg cctggaactg      900

gctggcaccc gcttcctgtg ggcactgcgt aaaccgacgg gtgtgagcga tgcggacctg      960

ctgccggccg gttttgaaga acgtacccgc ggccgtggtg ttgtcgcaac gcgttgggtc     1020

ccgcaaatga gcattctggc gcatgccgca gtgggcgcct ttctgaccca ctgtggttgg     1080

aacagcacga tcgaaggcct gatgtttggt cacccgctga ttatgctgcc gatcttcggc     1140

gatcagggtc cgaacgcacg tctgattgaa gcgaaaaatg ccggcctgca agttgcgcgc     1200

aacgatggcg acggttcttt cgaccgtgag ggtgtggctg cggccattcg cgcagtggct     1260

gttgaagaag aatcatcgaa agtttttcag gcgaaagcca aaaaactgca agaaatcgtc     1320

gcggatatgg cctgccacga acgctacatt gatggtttca ttcagcaact gcgctcctac     1380

aaagactaa                                                             1389


<210>  3
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Ala Asn Ala Glu Arg Met Ile Thr Arg Val His Ser Gln Arg Glu 
1               5                   10                  15      


Arg Leu Asn Glu Thr Leu Val Ser Glu Arg Asn Glu Val Leu Ala Leu 
            20                  25                  30          


Leu Ser Arg Val Glu Ala Lys Gly Lys Gly Ile Leu Gln Gln Asn Gln 
        35                  40                  45              


Ile Ile Ala Glu Phe Glu Ala Leu Pro Glu Gln Thr Arg Lys Lys Leu 
    50                  55                  60                  


Glu Gly Gly Pro Phe Phe Asp Leu Leu Lys Ser Thr Gln Glu Ala Ile 
65                  70                  75                  80  


Val Leu Pro Pro Trp Val Ala Leu Ala Val Arg Pro Arg Pro Gly Val 
                85                  90                  95      


Trp Glu Tyr Leu Arg Val Asn Leu His Ala Leu Val Val Glu Glu Leu 
            100                 105                 110         


Gln Pro Ala Glu Phe Leu His Phe Lys Glu Glu Leu Val Asp Gly Val 
        115                 120                 125             


Lys Asn Gly Asn Phe Thr Leu Glu Leu Asp Phe Glu Pro Phe Asn Ala 
    130                 135                 140                 


Ser Ile Pro Arg Pro Thr Leu His Lys Tyr Ile Gly Asn Gly Val Asp 
145                 150                 155                 160 


Phe Leu Asn Arg His Leu Ser Ala Lys Leu Phe His Asp Lys Glu Ser 
                165                 170                 175     


Leu Leu Pro Leu Leu Lys Phe Leu Arg Leu His Ser His Gln Gly Lys 
            180                 185                 190         


Asn Leu Met Leu Ser Glu Lys Ile Gln Asn Leu Asn Thr Leu Gln His 
        195                 200                 205             


Thr Leu Arg Lys Ala Glu Glu Tyr Leu Ala Glu Leu Lys Ser Glu Thr 
    210                 215                 220                 


Leu Tyr Glu Glu Phe Glu Ala Lys Phe Glu Glu Ile Gly Leu Glu Arg 
225                 230                 235                 240 


Gly Trp Gly Asp Asn Ala Glu Arg Val Leu Asp Met Ile Arg Leu Leu 
                245                 250                 255     


Leu Asp Leu Leu Glu Ala Pro Asp Pro Cys Thr Leu Glu Thr Phe Leu 
            260                 265                 270         


Gly Arg Val Pro Met Val Phe Asn Val Val Ile Leu Ser Pro His Gly 
        275                 280                 285             


Tyr Phe Ala Gln Asp Asn Val Leu Gly Tyr Pro Asp Thr Gly Gly Gln 
    290                 295                 300                 


Val Val Tyr Ile Leu Asp Gln Val Arg Ala Leu Glu Ile Glu Met Leu 
305                 310                 315                 320 


Gln Arg Ile Lys Gln Gln Gly Leu Asn Ile Lys Pro Arg Ile Leu Ile 
                325                 330                 335     


Leu Thr Arg Leu Leu Pro Asp Ala Val Gly Thr Thr Cys Gly Glu Arg 
            340                 345                 350         


Leu Glu Arg Val Tyr Asp Ser Glu Tyr Cys Asp Ile Leu Arg Val Pro 
        355                 360                 365             


Phe Arg Thr Glu Lys Gly Ile Val Arg Lys Trp Ile Ser Arg Phe Glu 
    370                 375                 380                 


Val Trp Pro Tyr Leu Glu Thr Tyr Thr Glu Asp Ala Ala Val Glu Leu 
385                 390                 395                 400 


Ser Lys Glu Leu Asn Gly Lys Pro Asp Leu Ile Ile Gly Asn Tyr Ser 
                405                 410                 415     


Asp Gly Asn Leu Val Ala Ser Leu Leu Ala His Lys Leu Gly Val Thr 
            420                 425                 430         


Gln Cys Thr Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser 
        435                 440                 445             


Asp Ile Tyr Trp Lys Lys Leu Asp Asp Lys Tyr His Phe Ser Cys Gln 
    450                 455                 460                 


Phe Thr Ala Asp Ile Phe Ala Met Asn His Thr Asp Phe Ile Ile Thr 
465                 470                 475                 480 


Ser Thr Phe Gln Glu Ile Ala Gly Ser Lys Glu Thr Val Gly Gln Tyr 
                485                 490                 495     


Glu Ser His Thr Ala Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His 
            500                 505                 510         


Gly Ile Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala 
        515                 520                 525             


Asp Met Ser Ile Tyr Phe Pro Tyr Thr Glu Glu Lys Arg Arg Leu Thr 
    530                 535                 540                 


Lys Phe His Ser Glu Ile Glu Glu Leu Leu Tyr Ser Asp Val Glu Asn 
545                 550                 555                 560 


Lys Glu His Leu Cys Val Leu Lys Asp Lys Lys Lys Pro Ile Leu Phe 
                565                 570                 575     


Thr Met Ala Arg Leu Asp Arg Val Lys Asn Leu Ser Gly Leu Val Glu 
            580                 585                 590         


Trp Tyr Gly Lys Asn Thr Arg Leu Arg Glu Leu Ala Asn Leu Val Val 
        595                 600                 605             


Val Gly Gly Asp Arg Arg Lys Glu Ser Lys Asp Asn Glu Glu Lys Ala 
    610                 615                 620                 


Glu Met Lys Lys Met Tyr Asp Leu Ile Glu Glu Tyr Lys Leu Asn Gly 
625                 630                 635                 640 


Gln Phe Arg Trp Ile Ser Ser Gln Met Asp Arg Val Arg Asn Gly Glu 
                645                 650                 655     


Leu Tyr Arg Tyr Ile Cys Asp Thr Lys Gly Ala Phe Val Gln Pro Ala 
            660                 665                 670         


Leu Tyr Glu Ala Phe Gly Leu Thr Val Val Glu Ala Met Thr Cys Gly 
        675                 680                 685             


Leu Pro Thr Phe Ala Thr Cys Lys Gly Gly Pro Ala Glu Ile Ile Val 
    690                 695                 700                 


His Gly Lys Ser Gly Phe His Ile Asp Pro Tyr His Gly Asp Gln Ala 
705                 710                 715                 720 


Ala Asp Thr Leu Ala Asp Phe Phe Thr Lys Cys Lys Glu Asp Pro Ser 
                725                 730                 735     


His Trp Asp Glu Ile Ser Lys Gly Gly Leu Gln Arg Ile Glu Glu Lys 
            740                 745                 750         


Tyr Thr Trp Gln Ile Tyr Ser Gln Arg Leu Leu Thr Leu Thr Gly Val 
        755                 760                 765             


Tyr Gly Phe Trp Lys His Val Ser Asn Leu Asp Arg Leu Glu Ala Arg 
    770                 775                 780                 


Arg Tyr Leu Glu Met Phe Tyr Ala Leu Lys Tyr Arg Pro Leu Ala Gln 
785                 790                 795                 800 


Ala Val Pro Leu Ala Gln Asp Asp 
                805             


<210>  4
<211>  2427
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atggcaaacg ctgaacgtat gataacgcgc gtccacagcc aacgtgagcg tttgaacgaa       60

acgcttgttt ctgagagaaa cgaagtcctt gccttgcttt ccagggttga agccaaaggt      120

aaaggtattt tacaacaaaa ccagatcatt gctgaattcg aagctttgcc tgaacaaacc      180

cggaagaaac ttgaaggtgg tcctttcttt gaccttctca aatccactca ggaagcaatt      240

gtgttgccac catgggttgc tctagctgtg aggccaaggc ctggtgtttg ggaatactta      300

cgagtcaatc tccatgctct tgtcgttgaa gaactccaac ctgctgagtt tcttcatttc      360

aaggaagaac tcgttgatgg agttaagaat ggtaatttca ctcttgagct tgatttcgag      420

ccattcaatg cgtctatccc tcgtccaaca ctccacaaat acattggaaa tggtgttgac      480

ttccttaacc gtcatttatc ggctaagctc ttccatgaca aggagagttt gcttccattg      540

cttaagttcc ttcgtcttca cagccaccag ggcaagaacc tgatgttgag cgagaagatt      600

cagaacctca acactctgca acacaccttg aggaaagcag aagagtatct agcagagctt      660

aagtccgaaa cactgtatga agagtttgag gccaagtttg aggagattgg tcttgagagg      720

ggatggggag acaatgcaga gcgtgtcctt gacatgatac gtcttctttt ggaccttctt      780

gaggcgcctg atccttgcac tcttgagact tttcttggaa gagtaccaat ggtgttcaac      840

gttgtgatcc tctctccaca tggttacttt gctcaggaca atgttcttgg ttaccctgac      900

actggtggac aggttgttta cattcttgat caagttcgtg ctctggagat agagatgctt      960

caacgtatta agcaacaagg actcaacatt aaaccaagga ttctcattct aactcgactt     1020

ctacctgatg cggtaggaac tacatgcggt gaacgtctcg agagagttta tgattctgag     1080

tactgtgata ttcttcgtgt gcccttcaga acagagaagg gtattgttcg caaatggatc     1140

tcaaggttcg aagtctggcc atatctagag acttacaccg aggatgctgc ggttgagcta     1200

tcgaaagaat tgaatggcaa gcctgacctt atcattggta actacagtga tggaaatctt     1260

gttgcttctt tattggctca caaacttggt gtcactcagt gtaccattgc tcatgctctt     1320

gagaaaacaa agtacccgga ttctgatatc tactggaaga agcttgacga caagtaccat     1380

ttctcatgcc agttcactgc ggatattttc gcaatgaacc acactgattt catcatcact     1440

agtactttcc aagaaattgc tggaagcaaa gaaactgttg ggcagtatga aagccacaca     1500

gcctttactc ttcccggatt gtatcgagtt gttcacggga ttgatgtgtt tgatcccaag     1560

ttcaacattg tctctcctgg tgctgatatg agcatctact tcccttacac agaggagaag     1620

cgtagattga ctaagttcca ctctgagatc gaggagctcc tctacagcga tgttgagaac     1680

aaagagcact tatgtgtgct caaggacaag aagaagccga ttctcttcac aatggctagg     1740

cttgatcgtg tcaagaactt gtcaggtctt gttgagtggt acgggaagaa cacccgcttg     1800

cgtgagctag ctaacttggt tgttgttgga ggagacagga ggaaagagtc aaaggacaat     1860

gaagagaaag cagagatgaa gaaaatgtat gatctcattg aggaatacaa gctaaacggt     1920

cagttcaggt ggatctcctc tcagatggac cgggtaagga acggtgagct gtaccggtac     1980

atctgtgaca ccaagggtgc ttttgtccaa cctgcattat atgaagcctt tgggttaact     2040

gttgtggagg ctatgacttg tggtttaccg actttcgcca cttgcaaagg tggtccagct     2100

gagatcattg tgcacggtaa atcgggtttc cacattgacc cttaccatgg tgatcaggct     2160

gctgatactc ttgctgattt cttcaccaag tgtaaggagg atccatctca ctgggatgag     2220

atctcaaaag gagggcttca gaggattgag gagaaataca cttggcaaat ctattcacag     2280

aggctcttga cattgactgg tgtgtatgga ttctggaagc atgtctcgaa ccttgaccgt     2340

cttgaggctc gccgttacct tgaaatgttc tatgcattga agtatcgccc attggctcag     2400

gctgttcctc ttgcacaaga tgattga                                         2427


<210>  5
<211>  1272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Asp Ser Gly Tyr Ser Ser Ser Tyr Ala Ala Ala Ala Gly Met His 
1               5                   10                  15      


Val Val Ile Cys Pro Trp Leu Ala Phe Gly His Leu Leu Pro Cys Leu 
            20                  25                  30          


Asp Leu Ala Gln Arg Leu Ala Ser Arg Gly His Arg Val Ser Phe Val 
        35                  40                  45              


Ser Thr Pro Arg Asn Ile Ser Arg Leu Pro Pro Val Arg Pro Ala Leu 
    50                  55                  60                  


Ala Pro Leu Val Ala Phe Val Ala Leu Pro Leu Pro Arg Val Glu Gly 
65                  70                  75                  80  


Leu Pro Asp Gly Ala Glu Ser Thr Asn Asp Val Pro His Asp Arg Pro 
                85                  90                  95      


Asp Met Val Glu Leu His Arg Arg Ala Phe Asp Gly Leu Ala Ala Pro 
            100                 105                 110         


Phe Ser Glu Phe Leu Gly Thr Ala Cys Ala Asp Trp Val Ile Val Asp 
        115                 120                 125             


Val Phe His His Trp Ala Ala Ala Ala Ala Leu Glu His Lys Val Pro 
    130                 135                 140                 


Cys Ala Met Met Leu Leu Gly Ser Ala His Met Ile Ala Ser Ile Ala 
145                 150                 155                 160 


Asp Arg Arg Leu Glu Arg Ala Glu Thr Glu Ser Pro Ala Ala Ala Gly 
                165                 170                 175     


Gln Gly Arg Pro Ala Ala Ala Pro Thr Phe Glu Val Ala Arg Met Lys 
            180                 185                 190         


Leu Ile Arg Thr Lys Gly Ser Ser Gly Met Ser Leu Ala Glu Arg Phe 
        195                 200                 205             


Ser Leu Thr Leu Ser Arg Ser Ser Leu Val Val Gly Arg Ser Cys Val 
    210                 215                 220                 


Glu Phe Glu Pro Glu Thr Val Pro Leu Leu Ser Thr Leu Arg Gly Lys 
225                 230                 235                 240 


Pro Ile Thr Phe Leu Gly Leu Met Pro Pro Leu His Glu Gly Arg Arg 
                245                 250                 255     


Glu Asp Gly Glu Asp Ala Thr Val Arg Trp Leu Asp Ala Gln Pro Ala 
            260                 265                 270         


Lys Ser Val Val Tyr Val Ala Leu Gly Ser Glu Val Pro Leu Gly Val 
        275                 280                 285             


Glu Lys Val His Glu Leu Ala Leu Gly Leu Glu Leu Ala Gly Thr Arg 
    290                 295                 300                 


Phe Leu Trp Ala Leu Arg Lys Pro Thr Gly Val Ser Asp Ala Asp Leu 
305                 310                 315                 320 


Leu Pro Ala Gly Phe Glu Glu Arg Thr Arg Gly Arg Gly Val Val Ala 
                325                 330                 335     


Thr Arg Trp Val Pro Gln Met Ser Ile Leu Ala His Ala Ala Val Gly 
            340                 345                 350         


Ala Phe Leu Thr His Cys Gly Trp Asn Ser Thr Ile Glu Gly Leu Met 
        355                 360                 365             


Phe Gly His Pro Leu Ile Met Leu Pro Ile Phe Gly Asp Gln Gly Pro 
    370                 375                 380                 


Asn Ala Arg Leu Ile Glu Ala Lys Asn Ala Gly Leu Gln Val Ala Arg 
385                 390                 395                 400 


Asn Asp Gly Asp Gly Ser Phe Asp Arg Glu Gly Val Ala Ala Ala Ile 
                405                 410                 415     


Arg Ala Val Ala Val Glu Glu Glu Ser Ser Lys Val Phe Gln Ala Lys 
            420                 425                 430         


Ala Lys Lys Leu Gln Glu Ile Val Ala Asp Met Ala Cys His Glu Arg 
        435                 440                 445             


Tyr Ile Asp Gly Phe Ile Gln Gln Leu Arg Ser Tyr Lys Asp Gly Ser 
    450                 455                 460                 


Gly Ala Asn Ala Glu Arg Met Ile Thr Arg Val His Ser Gln Arg Glu 
465                 470                 475                 480 


Arg Leu Asn Glu Thr Leu Val Ser Glu Arg Asn Glu Val Leu Ala Leu 
                485                 490                 495     


Leu Ser Arg Val Glu Ala Lys Gly Lys Gly Ile Leu Gln Gln Asn Gln 
            500                 505                 510         


Ile Ile Ala Glu Phe Glu Ala Leu Pro Glu Gln Thr Arg Lys Lys Leu 
        515                 520                 525             


Glu Gly Gly Pro Phe Phe Asp Leu Leu Lys Ser Thr Gln Glu Ala Ile 
    530                 535                 540                 


Val Leu Pro Pro Trp Val Ala Leu Ala Val Arg Pro Arg Pro Gly Val 
545                 550                 555                 560 


Trp Glu Tyr Leu Arg Val Asn Leu His Ala Leu Val Val Glu Glu Leu 
                565                 570                 575     


Gln Pro Ala Glu Phe Leu His Phe Lys Glu Glu Leu Val Asp Gly Val 
            580                 585                 590         


Lys Asn Gly Asn Phe Thr Leu Glu Leu Asp Phe Glu Pro Phe Asn Ala 
        595                 600                 605             


Ser Ile Pro Arg Pro Thr Leu His Lys Tyr Ile Gly Asn Gly Val Asp 
    610                 615                 620                 


Phe Leu Asn Arg His Leu Ser Ala Lys Leu Phe His Asp Lys Glu Ser 
625                 630                 635                 640 


Leu Leu Pro Leu Leu Lys Phe Leu Arg Leu His Ser His Gln Gly Lys 
                645                 650                 655     


Asn Leu Met Leu Ser Glu Lys Ile Gln Asn Leu Asn Thr Leu Gln His 
            660                 665                 670         


Thr Leu Arg Lys Ala Glu Glu Tyr Leu Ala Glu Leu Lys Ser Glu Thr 
        675                 680                 685             


Leu Tyr Glu Glu Phe Glu Ala Lys Phe Glu Glu Ile Gly Leu Glu Arg 
    690                 695                 700                 


Gly Trp Gly Asp Asn Ala Glu Arg Val Leu Asp Met Ile Arg Leu Leu 
705                 710                 715                 720 


Leu Asp Leu Leu Glu Ala Pro Asp Pro Cys Thr Leu Glu Thr Phe Leu 
                725                 730                 735     


Gly Arg Val Pro Met Val Phe Asn Val Val Ile Leu Ser Pro His Gly 
            740                 745                 750         


Tyr Phe Ala Gln Asp Asn Val Leu Gly Tyr Pro Asp Thr Gly Gly Gln 
        755                 760                 765             


Val Val Tyr Ile Leu Asp Gln Val Arg Ala Leu Glu Ile Glu Met Leu 
    770                 775                 780                 


Gln Arg Ile Lys Gln Gln Gly Leu Asn Ile Lys Pro Arg Ile Leu Ile 
785                 790                 795                 800 


Leu Thr Arg Leu Leu Pro Asp Ala Val Gly Thr Thr Cys Gly Glu Arg 
                805                 810                 815     


Leu Glu Arg Val Tyr Asp Ser Glu Tyr Cys Asp Ile Leu Arg Val Pro 
            820                 825                 830         


Phe Arg Thr Glu Lys Gly Ile Val Arg Lys Trp Ile Ser Arg Phe Glu 
        835                 840                 845             


Val Trp Pro Tyr Leu Glu Thr Tyr Thr Glu Asp Ala Ala Val Glu Leu 
    850                 855                 860                 


Ser Lys Glu Leu Asn Gly Lys Pro Asp Leu Ile Ile Gly Asn Tyr Ser 
865                 870                 875                 880 


Asp Gly Asn Leu Val Ala Ser Leu Leu Ala His Lys Leu Gly Val Thr 
                885                 890                 895     


Gln Cys Thr Ile Ala His Ala Leu Glu Lys Thr Lys Tyr Pro Asp Ser 
            900                 905                 910         


Asp Ile Tyr Trp Lys Lys Leu Asp Asp Lys Tyr His Phe Ser Cys Gln 
        915                 920                 925             


Phe Thr Ala Asp Ile Phe Ala Met Asn His Thr Asp Phe Ile Ile Thr 
    930                 935                 940                 


Ser Thr Phe Gln Glu Ile Ala Gly Ser Lys Glu Thr Val Gly Gln Tyr 
945                 950                 955                 960 


Glu Ser His Thr Ala Phe Thr Leu Pro Gly Leu Tyr Arg Val Val His 
                965                 970                 975     


Gly Ile Asp Val Phe Asp Pro Lys Phe Asn Ile Val Ser Pro Gly Ala 
            980                 985                 990         


Asp Met Ser Ile Tyr Phe Pro Tyr  Thr Glu Glu Lys Arg  Arg Leu Thr 
        995                 1000                 1005             


Lys Phe  His Ser Glu Ile Glu  Glu Leu Leu Tyr Ser  Asp Val Glu 
    1010                 1015                 1020             


Asn Lys  Glu His Leu Cys Val  Leu Lys Asp Lys Lys  Lys Pro Ile 
    1025                 1030                 1035             


Leu Phe  Thr Met Ala Arg Leu  Asp Arg Val Lys Asn  Leu Ser Gly 
    1040                 1045                 1050             


Leu Val  Glu Trp Tyr Gly Lys  Asn Thr Arg Leu Arg  Glu Leu Ala 
    1055                 1060                 1065             


Asn Leu  Val Val Val Gly Gly  Asp Arg Arg Lys Glu  Ser Lys Asp 
    1070                 1075                 1080             


Asn Glu  Glu Lys Ala Glu Met  Lys Lys Met Tyr Asp  Leu Ile Glu 
    1085                 1090                 1095             


Glu Tyr  Lys Leu Asn Gly Gln  Phe Arg Trp Ile Ser  Ser Gln Met 
    1100                 1105                 1110             


Asp Arg  Val Arg Asn Gly Glu  Leu Tyr Arg Tyr Ile  Cys Asp Thr 
    1115                 1120                 1125             


Lys Gly  Ala Phe Val Gln Pro  Ala Leu Tyr Glu Ala  Phe Gly Leu 
    1130                 1135                 1140             


Thr Val  Val Glu Ala Met Thr  Cys Gly Leu Pro Thr  Phe Ala Thr 
    1145                 1150                 1155             


Cys Lys  Gly Gly Pro Ala Glu  Ile Ile Val His Gly  Lys Ser Gly 
    1160                 1165                 1170             


Phe His  Ile Asp Pro Tyr His  Gly Asp Gln Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Ala Asp  Phe Phe Thr Lys Cys  Lys Glu Asp Pro Ser  His Trp Asp 
    1190                 1195                 1200             


Glu Ile  Ser Lys Gly Gly Leu  Gln Arg Ile Glu Glu  Lys Tyr Thr 
    1205                 1210                 1215             


Trp Gln  Ile Tyr Ser Gln Arg  Leu Leu Thr Leu Thr  Gly Val Tyr 
    1220                 1225                 1230             


Gly Phe  Trp Lys His Val Ser  Asn Leu Asp Arg Leu  Glu Ala Arg 
    1235                 1240                 1245             


Arg Tyr  Leu Glu Met Phe Tyr  Ala Leu Lys Tyr Arg  Pro Leu Ala 
    1250                 1255                 1260             


Gln Ala  Val Pro Leu Ala Gln  Asp Asp 
    1265                 1270         


<210>  6
<211>  3819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
atggattcgg gttactcttc ctcctatgcg gcggctgcgg gtatgcacgt tgttatctgt       60

ccgtggctgg cttttggtca cctgctgccg tgcctggatc tggcacagcg tctggcttca      120

cgcggccatc gtgtcagctt cgtgtctacc ccgcgcaata tttcgcgtct gccgccggtt      180

cgtccggcac tggctccgct ggttgcattt gtcgctctgc cgctgccgcg cgtggaaggt      240

ctgccggatg gtgcggaaag taccaacgac gtgccgcatg atcgcccgga catggttgaa      300

ctgcaccgtc gtgcattcga tggtctggca gcaccgtttt ccgaatttct gggtacggcg      360

tgcgccgatt gggtgatcgt tgacgtcttt catcactggg cggcggcggc ggcgctggaa      420

cataaagttc cgtgtgcaat gatgctgctg ggctcagctc acatgattgc gtcgatcgca      480

gaccgtcgcc tggaacgtgc agaaaccgaa agtccggctg cggccggcca gggtcgcccg      540

gcagctgcgc cgaccttcga agtggcccgc atgaaactga ttcgtacgaa aggcagctct      600

ggtatgagcc tggcagaacg ctttagtctg accctgtccc gtagttccct ggtggttggt      660

cgcagttgcg ttgaatttga accggaaacc gtcccgctgc tgtccacgct gcgtggtaaa      720

ccgatcacct ttctgggtct gatgccgccg ctgcatgaag gccgtcgcga agatggtgaa      780

gacgcaacgg tgcgttggct ggatgcacag ccggctaaaa gcgtcgtgta tgtcgccctg      840

ggctctgaag tgccgctggg tgtggaaaaa gttcacgaac tggcactggg cctggaactg      900

gctggcaccc gcttcctgtg ggcactgcgt aaaccgacgg gtgtgagcga tgcggacctg      960

ctgccggccg gttttgaaga acgtacccgc ggccgtggtg ttgtcgcaac gcgttgggtc     1020

ccgcaaatga gcattctggc gcatgccgca gtgggcgcct ttctgaccca ctgtggttgg     1080

aacagcacga tcgaaggcct gatgtttggt cacccgctga ttatgctgcc gatcttcggc     1140

gatcagggtc cgaacgcacg tctgattgaa gcgaaaaatg ccggcctgca agttgcgcgc     1200

aacgatggcg acggttcttt cgaccgtgag ggtgtggctg cggccattcg cgcagtggct     1260

gttgaagaag aatcatcgaa agtttttcag gcgaaagcca aaaaactgca agaaatcgtc     1320

gcggatatgg cctgccacga acgctacatt gatggtttca ttcagcaact gcgctcctac     1380

aaagacggtt ctggtgcaaa cgctgaacgt atgataacgc gcgtccacag ccaacgtgag     1440

cgtttgaacg aaacgcttgt ttctgagaga aacgaagtcc ttgccttgct ttccagggtt     1500

gaagccaaag gtaaaggtat tttacaacaa aaccagatca ttgctgaatt cgaagctttg     1560

cctgaacaaa cccggaagaa acttgaaggt ggtcctttct ttgaccttct caaatccact     1620

caggaagcaa ttgtgttgcc accatgggtt gctctagctg tgaggccaag gcctggtgtt     1680

tgggaatact tacgagtcaa tctccatgct cttgtcgttg aagaactcca acctgctgag     1740

tttcttcatt tcaaggaaga actcgttgat ggagttaaga atggtaattt cactcttgag     1800

cttgatttcg agccattcaa tgcgtctatc cctcgtccaa cactccacaa atacattgga     1860

aatggtgttg acttccttaa ccgtcattta tcggctaagc tcttccatga caaggagagt     1920

ttgcttccat tgcttaagtt ccttcgtctt cacagccacc agggcaagaa cctgatgttg     1980

agcgagaaga ttcagaacct caacactctg caacacacct tgaggaaagc agaagagtat     2040

ctagcagagc ttaagtccga aacactgtat gaagagtttg aggccaagtt tgaggagatt     2100

ggtcttgaga ggggatgggg agacaatgca gagcgtgtcc ttgacatgat acgtcttctt     2160

ttggaccttc ttgaggcgcc tgatccttgc actcttgaga cttttcttgg aagagtacca     2220

atggtgttca acgttgtgat cctctctcca catggttact ttgctcagga caatgttctt     2280

ggttaccctg acactggtgg acaggttgtt tacattcttg atcaagttcg tgctctggag     2340

atagagatgc ttcaacgtat taagcaacaa ggactcaaca ttaaaccaag gattctcatt     2400

ctaactcgac ttctacctga tgcggtagga actacatgcg gtgaacgtct cgagagagtt     2460

tatgattctg agtactgtga tattcttcgt gtgcccttca gaacagagaa gggtattgtt     2520

cgcaaatgga tctcaaggtt cgaagtctgg ccatatctag agacttacac cgaggatgct     2580

gcggttgagc tatcgaaaga attgaatggc aagcctgacc ttatcattgg taactacagt     2640

gatggaaatc ttgttgcttc tttattggct cacaaacttg gtgtcactca gtgtaccatt     2700

gctcatgctc ttgagaaaac aaagtacccg gattctgata tctactggaa gaagcttgac     2760

gacaagtacc atttctcatg ccagttcact gcggatattt tcgcaatgaa ccacactgat     2820

ttcatcatca ctagtacttt ccaagaaatt gctggaagca aagaaactgt tgggcagtat     2880

gaaagccaca cagcctttac tcttcccgga ttgtatcgag ttgttcacgg gattgatgtg     2940

tttgatccca agttcaacat tgtctctcct ggtgctgata tgagcatcta cttcccttac     3000

acagaggaga agcgtagatt gactaagttc cactctgaga tcgaggagct cctctacagc     3060

gatgttgaga acaaagagca cttatgtgtg ctcaaggaca agaagaagcc gattctcttc     3120

acaatggcta ggcttgatcg tgtcaagaac ttgtcaggtc ttgttgagtg gtacgggaag     3180

aacacccgct tgcgtgagct agctaacttg gttgttgttg gaggagacag gaggaaagag     3240

tcaaaggaca atgaagagaa agcagagatg aagaaaatgt atgatctcat tgaggaatac     3300

aagctaaacg gtcagttcag gtggatctcc tctcagatgg accgggtaag gaacggtgag     3360

ctgtaccggt acatctgtga caccaagggt gcttttgtcc aacctgcatt atatgaagcc     3420

tttgggttaa ctgttgtgga ggctatgact tgtggtttac cgactttcgc cacttgcaaa     3480

ggtggtccag ctgagatcat tgtgcacggt aaatcgggtt tccacattga cccttaccat     3540

ggtgatcagg ctgctgatac tcttgctgat ttcttcacca agtgtaagga ggatccatct     3600

cactgggatg agatctcaaa aggagggctt cagaggattg aggagaaata cacttggcaa     3660

atctattcac agaggctctt gacattgact ggtgtgtatg gattctggaa gcatgtctcg     3720

aaccttgacc gtcttgaggc tcgccgttac cttgaaatgt tctatgcatt gaagtatcgc     3780

ccattggctc aggctgttcc tcttgcacaa gatgattga                            3819


