                         SEQUENCE LISTING

<110>  EMORY UNIVERSITY
       Owonikoko, Taofeek k>
       Owonikoko, Taofeek K,
 
<120>  SELECTIVE CHEMOTHERAPY TREATMENTS AND DIAGNOSTIC METHODS RELATED 
       THERETO

<130>  12170 PCT

<150>  US 61/987,885
<151>  2014-05-02

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Cys Ala Cys Cys Thr Ala Cys Ala Cys Gly Ala Gly Gly Gly Cys 
1               5                   10                  15      


Gly Cys Cys Cys Cys Cys Ala Thr Cys Thr Thr Ala Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Ala Ala Gly Cys Ala Gly Thr Cys Gly Cys Thr Ala Thr Gly 
        35                  40                  45              


Ala Thr Gly Ala Thr Thr Ala Cys Ala Gly Cys Ala Gly Cys Thr Cys 
    50                  55                  60                  


Ala Cys Gly Thr Gly Ala Cys Gly Gly Ala Thr Ala Thr Gly Gly Thr 
65                  70                  75                  80  


Gly Gly Ala Ala Gly Thr Cys Gly Ala Gly Ala Cys Ala Gly Thr Thr 
                85                  90                  95      


Ala Cys Thr Cys Ala Ala Gly Cys Ala Gly Thr Cys Gly Ala Ala Gly 
            100                 105                 110         


Thr Gly Ala Thr Cys Thr Cys Thr Ala Cys Thr Cys Ala Ala Gly Thr 
        115                 120                 125             


Gly Gly Thr Cys Gly Thr Gly Ala Thr Cys Ala Gly Gly Thr Thr Gly 
    130                 135                 140                 


Gly Cys Ala Gly Ala Cys Ala Ala Gly Ala Ala Ala Gly Ala Gly Gly 
145                 150                 155                 160 


Gly Cys Thr Thr Cys Cys Cys Cys Cys Thr Thr Cys Thr Ala Thr Gly 
                165                 170                 175     


Gly Ala Ala Ala Gly Gly Gly Gly Gly Thr Ala Cys Cys Cys Thr Cys 
            180                 185                 190         


Cys Thr Cys Cys Ala Cys Gly Thr Gly Ala Thr Thr Cys Cys Thr Ala 
        195                 200                 205             


Cys Ala Gly Cys Ala Gly Thr Thr Cys Ala Ala Gly Cys Cys Gly Thr 
    210                 215                 220                 


Gly Gly Ala Ala Cys Ala Cys Cys Ala Ala Gly Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Gly Thr Gly Gly Cys Cys Gly Thr Gly Gly Ala Gly Gly Ala Ala Gly 
                245                 250                 255     


Cys Cys Gly Ala Thr Cys Thr Gly Ala Thr Ala Gly Ala Gly Gly Gly 
            260                 265                 270         


Gly Gly Ala Gly Gly Cys Ala Gly Ala Ala Gly Cys Ala Gly Ala Thr 
        275                 280                 285             


Ala Cys Thr Ala Gly Ala Ala Ala Cys Ala Ala Ala Cys Ala Ala Ala 
    290                 295                 300                 


Ala Cys Thr Thr Thr Gly Thr Ala Cys Cys Ala Ala Ala Ala Thr Cys 
305                 310                 315                 320 


Cys Cys Ala Gly Thr Thr Cys Ala Ala Ala Gly Ala Ala Ala Cys Ala 
                325                 330                 335     


Ala Ala Ala Ala Gly Thr Gly Gly Ala Ala Ala Cys Thr Ala Thr Thr 
            340                 345                 350         


Cys Thr Ala Thr Cys Ala Thr Ala Ala Cys Thr Ala Cys Cys Cys Ala 
        355                 360                 365             


Ala Gly Ala Ala Cys Thr Ala Cys Thr Ala Ala Ala Ala Gly Gly Ala 
    370                 375                 380                 


Ala Ala Ala Ala Thr Thr Gly Thr Gly Thr Thr Ala Cys Cys Thr Thr 
385                 390                 395                 400 


Thr Thr Thr Thr Ala Ala Ala Ala Thr Thr Cys Cys Cys Thr Gly Thr 
                405                 410                 415     


Thr Ala Ala Gly Cys Thr Cys Cys Cys Cys Thr Cys Cys Ala Thr Ala 
            420                 425                 430         


Ala Thr Thr Thr Thr Thr Ala Thr Gly Thr Thr Cys Thr Thr Gly Thr 
        435                 440                 445             


Gly Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala Gly Thr Ala Ala Ala 
    450                 455                 460                 


Ala Cys Ala Thr Gly Thr Thr Thr Ala Ala Thr Thr Thr Thr Ala Thr 
465                 470                 475                 480 


Thr Thr Gly Ala Cys Thr Thr Thr Thr Gly Cys Ala Thr Thr Gly Cys 
                485                 490                 495     


Thr Thr Thr Thr Cys Ala Ala Cys Ala Ala Gly Cys Ala Ala Ala Thr 
            500                 505                 510         


Gly Thr Thr Ala Ala Ala Thr Gly Thr Gly Thr Thr Ala Ala Gly Ala 
        515                 520                 525             


Cys Thr Thr Ala Thr Ala Cys Thr Ala Gly Thr Gly Thr Thr Gly Thr 
    530                 535                 540                 


Ala Ala Cys Thr Thr Thr Cys Cys Ala Ala Gly Thr Ala Ala Ala Ala 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Cys Cys Thr Ala Ala Ala Gly Gly Cys Cys Ala 
                565                 570                 575     


Cys Thr Thr Cys Cys Thr Ala Thr Cys Thr Gly Ala Thr Thr Thr Thr 
            580                 585                 590         


Thr Cys Cys Cys Ala Gly Thr Ala Ala Ala Thr Gly Ala Gly Gly Cys 
        595                 600                 605             


Ala Gly Gly Cys Ala Ala Thr Thr Cys Thr Ala Ala Gly Ala Thr Cys 
    610                 615                 620                 


Thr Thr Cys Cys Ala Cys Ala Ala Ala Ala Cys Ala Thr Cys Thr Ala 
625                 630                 635                 640 


Gly Cys Cys Ala Thr Cys Thr Ala Ala Ala Ala Thr Gly Gly Ala Gly 
                645                 650                 655     


Ala Gly Ala Thr Gly Ala Ala Thr Cys Ala Thr Thr Cys Thr Ala Cys 
            660                 665                 670         


Cys Thr Ala Cys Ala Cys Ala Ala Ala Cys Ala Ala Gly Cys Thr Ala 
        675                 680                 685             


Gly Cys Thr Ala Thr Thr Ala Gly Ala Gly Gly Gly Thr Gly Gly Thr 
    690                 695                 700                 


Thr Gly Gly Gly Ala Thr Ala Thr Gly Cys Thr Ala Cys Thr Cys Ala 
705                 710                 715                 720 


Thr Ala Ala Gly Ala Thr Thr Thr Cys Ala Gly Gly Gly Thr Gly Thr 
                725                 730                 735     


Cys Thr Thr Cys Cys Ala Ala Cys Thr Gly Ala Ala Ala Thr Cys Thr 
            740                 745                 750         


Cys Ala Ala Thr Gly Thr Thr Cys Thr Thr Ala Gly Thr Ala Thr Gly 
        755                 760                 765             


Ala Ala Ala Ala Ala Cys Cys Thr Gly Ala Ala Ala Thr Cys Gly Cys 
    770                 775                 780                 


Ala Thr Gly Cys Cys Thr Ala Thr Thr Cys Ala Cys Cys Cys Ala Gly 
785                 790                 795                 800 


Thr Ala Ala Ala Cys Cys Cys Ala Ala Ala Ala Ala Ala Gly Cys Ala 
                805                 810                 815     


Ala Ala Thr Gly Gly Ala Thr Ala Ala Thr Gly Cys Thr Gly Gly Cys 
            820                 825                 830         


Cys Ala Thr Thr Cys Thr Gly Cys Cys Thr Thr Thr Cys Thr Gly Ala 
        835                 840                 845             


Cys Ala Thr Thr Thr Cys Cys Thr Thr Gly Gly Gly Ala Ala Thr Cys 
    850                 855                 860                 


Thr Gly Cys Ala Ala Gly Ala Ala Cys Cys Thr Cys Cys Cys Cys Thr 
865                 870                 875                 880 


Thr Thr Cys Cys Cys Cys Thr Cys Cys Cys Cys Cys Ala Ala Thr Ala 
                885                 890                 895     


Ala Gly Ala Cys Cys Ala Thr Thr Thr Ala Ala Gly Thr Gly Thr Gly 
            900                 905                 910         


Thr Gly Cys Thr Ala Ala Ala Cys Ala Ala Cys Thr Ala Ala Gly Ala 
        915                 920                 925             


Ala Thr Ala Cys Thr Ala Ala Ala Thr 
    930                 935         


<210>  2
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ala Gly Ala Thr Gly Gly Thr Gly Cys Cys Cys Thr Thr Gly Ala 
1               5                   10                  15      


Thr Thr Ala Gly Ala Ala Gly Thr Gly Thr Cys Thr Gly Gly Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Thr Ala Ala Ala Thr Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Gly Ala Thr Ala Ala Gly Ala Thr Thr Cys Ala Gly Thr Thr Gly Gly 
    50                  55                  60                  


Thr Thr Thr Thr Gly Gly Ala Ala Ala Ala Thr Gly Thr Thr Ala Ala 
65                  70                  75                  80  


Ala Gly Thr Cys Thr Thr Ala Ala Ala Ala Thr Ala Ala Thr Gly Cys 
                85                  90                  95      


Gly Thr Cys Cys Ala Thr Cys Thr Gly Ala Ala Gly Ala Ala Thr Thr 
            100                 105                 110         


Thr Thr Thr Thr Cys Thr Ala Ala Ala Ala Cys Cys Ala Gly Ala Gly 
        115                 120                 125             


Thr Thr Thr Ala Thr Ala Ala Ala Ala Ala Thr Ala Thr Cys Ala Cys 
    130                 135                 140                 


Thr Gly Ala Thr Ala Cys Ala Gly Cys Cys Thr Gly Cys Cys Cys Cys 
145                 150                 155                 160 


Cys Thr Cys Ala Thr Thr Thr Cys Cys Cys Thr Gly Cys Cys Ala Cys 
                165                 170                 175     


Ala Gly Gly Ala Gly Ala Thr Gly Thr Cys Thr Thr Gly Gly Ala Cys 
            180                 185                 190         


Thr Ala Gly Ala Gly Ala Cys Ala Cys Thr Thr Gly Thr Thr Thr Ala 
        195                 200                 205             


Ala Thr Ala Ala Thr Ala Gly Cys Thr Thr Gly Thr Cys Thr Cys Thr 
    210                 215                 220                 


Gly Ala Thr Ala Thr Thr Cys Cys Cys Ala Gly Thr Ala Gly Cys Thr 
225                 230                 235                 240 


Thr Cys Cys Cys Thr Cys Thr Gly Thr Gly Thr Gly Ala Gly Gly Ala 
                245                 250                 255     


Ala Ala Gly Gly Ala Thr Ala Gly Ala Ala Ala Thr Gly Thr Thr Cys 
            260                 265                 270         


Ala Gly Gly Ala Cys Ala Thr Cys Ala Thr Cys Ala Thr Ala Cys Ala 
        275                 280                 285             


Gly Gly Cys Thr Cys Cys Thr Cys Ala Thr Cys Thr Ala Cys Ala Ala 
    290                 295                 300                 


Ala Gly Thr Thr Cys Cys Ala Gly Thr Ala Gly Cys Ala Gly Thr Gly 
305                 310                 315                 320 


Ala Cys Gly Cys Cys Thr Ala Cys Ala Cys Gly Gly Ala Ala Gly Ala 
                325                 330                 335     


Cys Thr Thr Gly Gly Ala 
            340         


<210>  3
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Thr Gly Thr Gly Ala Cys Thr Gly Ala Ala Gly Ala Ala Ala Thr 
1               5                   10                  15      


Ala Thr Cys Ala Ala Ala Thr Gly Thr Thr Thr Cys Cys Thr Ala Gly 
            20                  25                  30          


Thr Ala Ala Gly Ala Cys Ala Gly Cys Ala Ala Cys Thr Cys Ala 
        35                  40                  45          


<210>  4
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Cys Thr Cys Thr Ala Gly Gly Ala Thr Gly Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ala Gly Gly Thr Gly Thr Cys Thr Gly Ala Cys Cys Gly Thr Ala Ala 
            20                  25                  30          


Ala Thr Thr Ala Cys Ala Cys Cys Thr Gly Cys Ala Gly Thr 
        35                  40                  45      


<210>  5
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ala Cys Cys Ala Gly Cys Ala Gly Ala Cys Thr Ala Ala Thr Gly 
1               5                   10                  15      


Gly Gly Gly Ala Thr Gly Ala Gly Gly Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Ala Cys Ala Ala Gly Ala Thr Gly Ala Thr Gly Ala Ala Cys Ala Cys 
        35                  40                  45              


Cys Ala Gly Thr Ala Thr Gly Thr Cys Ala Gly Ala Cys Ala Ala Thr 
    50                  55                  60                  


Gly Ala Cys Thr Thr Gly Gly Gly Ala Gly Cys Thr Gly Gly Ala Ala 
65                  70                  75                  80  


Thr Cys Ala Ala Gly Gly Ala Cys Ala Thr Gly Ala Cys Cys Ala Ala 
                85                  90                  95      


Gly Ala Gly Cys Ala Gly Cys Ala Ala Gly Ala Ala Cys Ala Ala Ala 
            100                 105                 110         


Ala Gly Gly Gly Ala Gly Ala Cys Thr Gly Ala Cys Ala Cys Ala Thr 
        115                 120                 125             


Thr Gly Ala Thr Cys Ala Cys Thr Thr Thr Cys Thr Cys Ala Ala Cys 
    130                 135                 140                 


Cys Thr Thr Thr Gly Ala Thr Cys Thr Cys Thr Thr Gly Ala Gly Ala 
145                 150                 155                 160 


<210>  6
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Thr Gly Gly Thr Thr Cys Ala Cys Ala Thr Thr Thr Gly Ala Gly 
1               5                   10                  15      


Thr Ala Ala Ala Gly Ala Cys Ala Gly Gly Gly Gly Ala Gly Thr Thr 
            20                  25                  30          


Thr Gly Thr Thr Thr Thr Cys Ala Gly Ala Ala Thr Gly Ala Cys Ala 
        35                  40                  45              


Thr Ala Cys Thr Ala Gly Thr Cys Thr Gly Cys Ala Gly Gly Ala Thr 
    50                  55                  60                  


Gly Ala Ala Thr Thr Thr Cys Ala Thr Ala Ala Cys Thr Gly Ala Cys 
65                  70                  75                  80  


Ala Thr Thr Gly Cys Ala Cys Cys Thr Thr Gly Gly Ala Cys Thr Gly 
                85                  90                  95      


Cys Ala Ala Cys Thr Ala Gly Gly Ala Cys Thr Thr Thr Cys Ala Cys 
            100                 105                 110         


Thr Gly Gly Ala Ala Thr Cys Ala 
        115                 120 


<210>  7
<211>  1737
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ala Ala Ala Gly Ala Gly Thr Thr Thr Thr Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ala Ala Ala Cys Thr Gly Gly Gly Cys Ala Thr Ala Gly Gly Cys Thr 
            20                  25                  30          


Cys Ala Gly Cys Ala Ala Ala Ala Cys Cys Ala Ala Ala Cys Ala Gly 
        35                  40                  45              


Ala Ala Gly Ala Gly Gly Ala Ala Cys Ala Gly Ala Ala Ala Ala Ala 
    50                  55                  60                  


Gly Ala Ala Ala Cys Ala Ala Ala Ala Ala Gly Cys Ala Gly Ala Ala 
65                  70                  75                  80  


Cys Ala Gly Thr Cys Ala Gly Ala Ala Thr Ala Gly Ala Ala Thr Cys 
                85                  90                  95      


Ala Thr Gly Gly Ala Gly Gly Ala Ala Ala Ala Cys Thr Cys Ala Thr 
            100                 105                 110         


Thr Ala Gly Ala Ala Thr Thr Cys Thr Thr Ala Ala Gly Thr Gly Ala 
        115                 120                 125             


Thr Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Gly Ala Gly Ala Thr 
    130                 135                 140                 


Cys Ala Gly Gly Ala Cys Cys Cys Ala Thr Cys Thr Cys Ala Gly Ala 
145                 150                 155                 160 


Gly Thr Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Ala Cys Ala Thr 
                165                 170                 175     


Thr Gly Ala Ala Ala Ala Gly Ala Cys Cys Ala Gly Ala Ala Gly Ala 
            180                 185                 190         


Gly Ala Ala Thr Cys Ala Gly Ala Ala Thr Ala Thr Cys Cys Cys Thr 
        195                 200                 205             


Thr Cys Ala Thr Thr Gly Ala Thr Gly Gly Thr Cys Thr Ala Cys Ala 
    210                 215                 220                 


Ala Ala Ala Thr Gly Ala Ala Gly Thr Cys Gly Gly Ala Gly Ala Thr 
225                 230                 235                 240 


Thr Thr Thr Gly Thr Gly Ala Cys Thr Gly Gly Ala Thr Ala Thr Ala 
                245                 250                 255     


Ala Ala Gly Ala Ala Ala Ala Ala Ala Gly Ala Thr Gly Gly Ala Ala 
            260                 265                 270         


Ala Ala Ala Thr Ala Ala Ala Gly Ala Thr Cys Cys Thr Ala Ala Ala 
        275                 280                 285             


Gly Ala Cys Ala Gly Thr Thr Thr Cys Cys Ala Ala Ala Ala Cys Gly 
    290                 295                 300                 


Thr Thr Ala Thr Gly Thr Cys Thr Ala Thr Ala Gly Thr Thr Gly Ala 
305                 310                 315                 320 


Ala Thr Thr Ala Gly Ala Cys Ala Ala Cys Ala Cys Ala Cys Cys Ala 
                325                 330                 335     


Ala Ala Gly Ala Ala Thr Thr Ala Cys Cys Thr Cys Thr Cys Thr Ala 
            340                 345                 350         


Ala Gly Gly Ala Ala Gly Gly Thr Gly Ala Thr Ala Ala Cys Thr Thr 
        355                 360                 365             


Gly Thr Thr Thr Gly Thr Ala Ala Gly Thr Thr Thr Gly Thr Thr Ala 
    370                 375                 380                 


Cys Thr Gly Ala Gly Gly Cys Cys Ala Ala Ala Thr Gly Ala Ala Ala 
385                 390                 395                 400 


Thr Cys Thr Cys Cys Gly Thr Thr Ala Cys Thr Thr Gly Thr Cys Cys 
                405                 410                 415     


Ala Ala Thr Ala Cys Thr Gly Ala Cys Thr Cys Ala Ala Ala Ala Cys 
            420                 425                 430         


Cys Thr Thr Thr Cys Cys Thr Gly Thr Gly Thr Ala Ala Cys Ala Ala 
        435                 440                 445             


Cys Thr Gly Ala Thr Gly Ala Cys Thr Gly Cys Thr Cys Thr Gly Gly 
    450                 455                 460                 


Cys Ala Thr Gly Ala Ala Gly Gly Thr Ala Gly Ala Ala Ala Ala Gly 
465                 470                 475                 480 


Cys Ala Thr Ala Thr Thr Ala Gly Ala Ala Ala Thr Ala Gly Gly Cys 
                485                 490                 495     


Ala Thr Ala Cys Cys Ala Thr Ala Gly Cys Ala Thr Thr Ala Gly Ala 
            500                 505                 510         


Cys Ala Cys Cys Cys Ala Gly Gly Ala Cys Cys Thr Thr Thr Cys Thr 
        515                 520                 525             


Gly Cys Gly Gly Ala Ala Ala Cys Thr Thr Cys Ala Thr Gly Cys Thr 
    530                 535                 540                 


Thr Ala Thr Thr Thr Ala Thr Gly Ala Ala Gly Ala Ala Gly Ala Gly 
545                 550                 555                 560 


Ala Gly Ala Ala Ala Thr Ala Gly Thr Ala Gly Ala Thr Ala Ala Ala 
                565                 570                 575     


Ala Ala Thr Cys Thr Cys Thr Cys Ala Cys Ala Thr Gly Ala Ala Cys 
            580                 585                 590         


Cys Cys Ala Thr Thr Cys Thr Gly Thr Gly Cys Cys Ala Thr Cys Ala 
        595                 600                 605             


Ala Cys Ala Thr Gly Gly Ala Ala Thr Cys Ala Gly Ala Ala Thr Gly 
    610                 615                 620                 


Thr Cys Ala Gly Ala Thr Ala Ala Ala Gly Thr Thr Thr Thr Ala Ala 
625                 630                 635                 640 


Gly Ala Gly Ala Gly Gly Ala Ala Cys Ala Ala Gly Thr Gly Thr Ala 
                645                 650                 655     


Thr Ala Cys Ala Ala Cys Thr Ala Ala Ala Ala Thr Cys Ala Ala Thr 
            660                 665                 670         


Cys Ala Cys Thr Gly Gly Gly Cys Thr Thr Thr Thr Thr Thr Cys Ala 
        675                 680                 685             


Cys Ala Ala Cys Cys Ala Ala Thr Thr Thr Ala Thr Cys Thr Gly Ala 
    690                 695                 700                 


Thr Gly Ala Ala Gly Ala Thr Thr Thr Ala Cys Ala Gly Cys Thr Gly 
705                 710                 715                 720 


Gly Gly Cys Thr Cys Thr Gly Ala Cys Ala Gly Ala Cys Ala Gly Cys 
                725                 730                 735     


Cys Cys Thr Ala Thr Thr Thr Thr Gly Gly Thr Ala Gly Cys Thr Gly 
            740                 745                 750         


Gly Cys Cys Thr Gly Cys Ala Gly Gly Ala Cys Cys Thr Cys Ala Thr 
        755                 760                 765             


Ala Ala Gly Thr Thr Thr Ala Thr Ala Thr Gly Thr Gly Ala Ala Cys 
    770                 775                 780                 


Ala Gly Ala Gly Ala Cys Cys Ala Ala Ala Gly Ala Ala Ala Gly Ala 
785                 790                 795                 800 


Thr Ala Gly Ala Gly Cys Ala Thr Gly Thr Ala Ala Gly Thr Thr Gly 
                805                 810                 815     


Gly Cys Thr Gly Gly Thr Cys Cys Thr Gly Ala Cys Ala Gly Cys Ala 
            820                 825                 830         


Gly Gly Gly Gly Gly Cys Ala Ala Thr Gly Gly Ala Thr Thr Cys Ala 
        835                 840                 845             


Ala Ala Thr Gly Ala Thr Cys Thr Thr Cys Ala Cys Thr Thr Cys Gly 
    850                 855                 860                 


Gly Thr Gly Gly Cys Ala Gly Cys Ala Thr Cys Ala Gly Ala Ala Cys 
865                 870                 875                 880 


Cys Ala Gly Gly Ala Ala Ala Cys Ala Ala Thr Cys Cys Ala Gly Ala 
                885                 890                 895     


Ala Ala Thr Ala Thr Thr Gly Ala Cys Ala Gly Ala Cys Ala Ala Ala 
            900                 905                 910         


Cys Thr Ala Cys Thr Gly Ala Thr Ala Gly Gly Ala Ala Ala Thr Gly 
        915                 920                 925             


Ala Ala Gly Ala Thr Thr Thr Thr Thr Cys Ala Cys Cys Thr Cys Cys 
    930                 935                 940                 


Ala Cys Cys Thr Gly Ala Ala Ala Cys Thr Ala Thr Gly Gly Ala Thr 
945                 950                 955                 960 


Thr Cys Ala Thr Thr Cys Ala Thr Ala Gly Ala Ala Ala Cys Ala Ala 
                965                 970                 975     


Ala Cys Cys Thr Cys Thr Thr Cys Ala Gly Ala Ala Gly Cys Thr Gly 
            980                 985                 990         


Cys Thr Thr Ala Cys Cys Thr Cys  Ala Ala Cys Cys Gly  Gly Ala Thr 
        995                 1000                 1005             


Ala Thr  Ala Cys Cys Ala Ala  Ala Gly Ala Ala Thr  Gly Cys Cys 
    1010                 1015                 1020             


Thr Thr  Ala Gly Ala Ala Thr  Cys Ala Ala Cys Ala  Ala Ala Ala 
    1025                 1030                 1035             


Ala Ala  Thr Ala Ala Gly Ala  Ala Ala Ala Gly Gly  Ala Gly Gly 
    1040                 1045                 1050             


Ala Ala  Gly Ala Ala Ala Ala  Gly Gly Ala Thr Thr  Thr Thr Cys 
    1055                 1060                 1065             


Ala Ala  Thr Thr Thr Gly Gly  Thr Ala Cys Cys Ala  Ala Ala Thr 
    1070                 1075                 1080             


Thr Thr  Thr Gly Ala Cys Thr  Thr Ala Thr Thr Ala  Gly Gly Ala 
    1085                 1090                 1095             


Cys Ala  Gly Ala Gly Thr Cys  Gly Thr Ala Thr Cys  Gly Gly Thr 
    1100                 1105                 1110             


Gly Thr  Ala Ala Ala Ala Gly  Ala Ala Ala Gly Gly  Gly Ala Gly 
    1115                 1120                 1125             


Ala Ala  Ala Thr Gly Thr Gly  Ala Cys Cys Thr Gly  Thr Thr Ala 
    1130                 1135                 1140             


Ala Cys  Ala Ala Ala Ala Ala  Ala Cys Cys Ala Thr  Gly Gly Ala 
    1145                 1150                 1155             


Cys Thr  Ala Ala Ala Ala Ala  Thr Thr Ala Cys Thr  Thr Thr Gly 
    1160                 1165                 1170             


Gly Gly  Ala Gly Ala Ala Gly  Ala Ala Ala Ala Ala  Gly Ala Thr 
    1175                 1180                 1185             


Ala Gly  Ala Ala Thr Thr Thr  Cys Ala Gly Ala Ala  Ala Gly Gly 
    1190                 1195                 1200             


Ala Ala  Cys Ala Gly Thr Gly  Ala Ala Gly Ala Gly  Gly Ala Gly 
    1205                 1210                 1215             


Ala Ala  Thr Ala Ala Ala Cys  Ala Ala Ala Ala Ala  Cys Thr Thr 
    1220                 1225                 1230             


Ala Thr  Gly Ala Cys Cys Thr  Thr Thr Gly Ala Thr  Cys Ala Thr 
    1235                 1240                 1245             


Cys Ala  Thr Cys Cys Ala Thr  Thr Gly Thr Gly Gly  Thr Thr Thr 
    1250                 1255                 1260             


Thr Ala  Cys Cys Thr Thr Gly  Ala Thr Ala Thr Thr  Ala Thr Cys 
    1265                 1270                 1275             


Ala Ala  Ala Gly Cys Thr Ala  Cys Cys Cys Cys Thr  Thr Thr Ala 
    1280                 1285                 1290             


Ala Ala  Thr Ala Thr Thr Gly  Ala Thr Gly Gly Ala  Cys Ala Gly 
    1295                 1300                 1305             


Cys Gly  Thr Thr Ala Thr Thr  Cys Thr Cys Ala Thr  Thr Gly Cys 
    1310                 1315                 1320             


Cys Thr  Gly Thr Cys Ala Thr  Thr Thr Ala Ala Cys  Ala Gly Ala 
    1325                 1330                 1335             


Cys Thr  Ala Ala Gly Gly Thr  Gly Cys Thr Cys Thr  Gly Cys Ala 
    1340                 1345                 1350             


Thr Cys  Thr Thr Thr Ala Thr  Ala Cys Ala Ala Ala  Ala Ala Thr 
    1355                 1360                 1365             


Thr Ala  Thr Ala Thr Thr Cys  Cys Thr Thr Cys Thr  Thr Thr Thr 
    1370                 1375                 1380             


Gly Thr  Gly Cys Thr Ala Cys  Ala Thr Ala Ala Thr  Thr Thr Ala 
    1385                 1390                 1395             


Thr Cys  Thr Ala Gly Thr Ala  Thr Thr Thr Gly Gly  Ala Ala Gly 
    1400                 1405                 1410             


Cys Cys  Ala Thr Cys Thr Thr  Thr Thr Ala Cys Ala  Ala Ala Cys 
    1415                 1420                 1425             


Ala Ala  Gly Ala Ala Ala Cys  Thr Gly Thr Thr Thr  Thr Thr Gly 
    1430                 1435                 1440             


Ala Cys  Thr Thr Thr Cys Gly  Ala Ala Thr Cys Thr  Cys Ala Gly 
    1445                 1450                 1455             


Ala Cys  Ala Ala Gly Ala Gly  Thr Ala Gly Gly Thr  Ala Ala Thr 
    1460                 1465                 1470             


Ala Ala  Ala Cys Thr Ala Ala  Ala Thr Gly Ala Thr  Gly Cys Ala 
    1475                 1480                 1485             


Gly Gly  Gly Thr Thr Thr Ala  Thr Thr Thr Cys Thr  Cys Cys Ala 
    1490                 1495                 1500             


Gly Ala  Ala Ala Thr Thr Thr  Thr Ala Cys Ala Thr  Ala Gly Thr 
    1505                 1510                 1515             


Cys Ala  Thr Cys Cys Thr Gly  Ala Thr Ala Cys Thr  Thr Cys Gly 
    1520                 1525                 1530             


Thr Gly  Cys Thr Cys Thr Thr  Thr Gly Gly Gly Ala  Gly Thr Cys 
    1535                 1540                 1545             


Ala Cys  Thr Thr Cys Thr Gly  Ala Thr Thr Thr Thr  Cys Ala Cys 
    1550                 1555                 1560             


Thr Thr  Thr Thr Thr Ala Ala  Ala Thr Gly Ala Ala  Ala Gly Gly 
    1565                 1570                 1575             


Thr Thr  Thr Gly Ala Thr Ala  Gly Ala Ala Ala Gly  Cys Thr Gly 
    1580                 1585                 1590             


Ala Ala  Ala Ala Gly Ala Thr  Gly Gly Gly Ala Ala  Gly Ala Ala 
    1595                 1600                 1605             


Cys Cys  Thr Ala Ala Gly Gly  Ala Ala Thr Thr Ala  Cys Cys Ala 
    1610                 1615                 1620             


Gly Cys  Thr Gly Ala Gly Gly  Ala Cys Ala Gly Cys  Cys Ala Ala 
    1625                 1630                 1635             


Gly Ala  Cys Thr Thr Ala Ala  Cys Ala Ala Gly Cys  Ala Cys Thr 
    1640                 1645                 1650             


Gly Ala  Cys Thr Ala Cys Cys  Gly Thr Thr Cys Cys  Cys Thr Thr 
    1655                 1660                 1665             


Gly Ala  Gly Cys Thr Ala Cys  Cys Ala Thr Thr Ala  Thr Cys Ala 
    1670                 1675                 1680             


Cys Ala  Ala Gly Gly Gly Thr  Thr Thr Gly Cys Cys  Thr Thr Thr 
    1685                 1690                 1695             


Cys Ala  Ala Thr Thr Ala Gly  Thr Ala Ala Ala Gly  Cys Thr Thr 
    1700                 1705                 1710             


Thr Thr  Thr Gly Gly Ala Thr  Cys Thr Cys Cys Ala  Gly Gly Cys 
    1715                 1720                 1725             


Gly Thr  Thr Cys Cys Ala Ala  Thr Gly 
    1730                 1735         


<210>  8
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Thr Cys Cys Thr Thr Gly Thr Thr Gly Cys Cys Thr Gly Ala Thr 
1               5                   10                  15      


Gly Ala Cys Thr Ala Thr Gly Thr Gly Gly Thr Thr Cys Cys Cys Cys 
            20                  25                  30          


Thr Thr Gly Ala Cys Thr Gly Gly Ala Ala Gly Ala Cys Ala Cys Thr 
        35                  40                  45              


Ala Ala Ala Gly Ala Thr Gly Ala Thr Cys Thr Ala Cys Thr Thr Gly 
    50                  55                  60                  


Cys Ala Ala Thr Gly Gly Ala Ala Gly Ala Thr Gly Thr Cys Ala Gly 
65                  70                  75                  80  


Thr Gly Gly Ala 
                


<210>  9
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ala Ala Gly Ala Cys Ala Gly Ala Ala Gly Ala Ala Gly Ala Thr 
1               5                   10                  15      


Thr Gly Gly Thr Thr Gly Ala Ala Ala Ala Ala Thr Gly Ala Ala Ala 
            20                  25                  30          


Ala Thr Thr Cys Cys Thr Thr Gly Ala Ala Cys 
        35                  40              


<210>  10
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Gly Ala Gly Thr Thr Cys Thr Gly Cys Thr Gly Thr Cys Thr Thr 
1               5                   10                  15      


Cys Ala Thr Gly Gly Thr Ala Cys Thr Gly Cys Thr Gly Ala Ala Gly 
            20                  25                  30          


Ala Thr Cys Ala Thr Gly Ala Thr Cys Ala Cys Gly Gly Ala Gly Ala 
        35                  40                  45              


Ala Ala Ala Gly Thr Cys Ala Gly Ala Gly Thr Gly Cys Thr Cys Ala 
    50                  55                  60                  


Gly Thr Gly Cys Cys Ala Ala Cys Cys Cys Ala Ala Gly Gly Gly Ala 
65                  70                  75                  80  


Thr Thr Cys Thr Thr Thr Cys Cys Ala Gly Ala Gly Ala Cys Gly Thr 
                85                  90                  95      


Ala Cys Cys Cys Gly Thr Thr Gly Gly Ala Thr Ala Cys Cys Ala Ala 
            100                 105                 110         


Ala Ala Thr Thr Ala Gly Thr Thr Thr Gly Gly Ala Thr Ala Ala Thr 
        115                 120                 125             


Cys Thr Gly Thr Thr Cys Ala Ala Cys Cys Ala Thr Thr Cys Thr Thr 
    130                 135                 140                 


Gly Ala Thr Ala Ala Gly Thr Thr Ala Thr Cys Thr Gly Ala Ala Thr 
145                 150                 155                 160 


Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Cys Thr Cys Ala Ala Cys 
                165                 170                 175     


Ala Gly Ala Gly Gly Ala Gly Gly Thr Ala Ala Cys Ala Ala Thr Thr 
            180                 185                 190         


Thr Gly Ala Ala Cys Ala Thr Thr Thr Thr Ala Thr Thr Gly Thr Cys 
        195                 200                 205             


Thr Ala Ala Thr Thr Thr Gly Ala Ala Gly Ala Thr Gly Thr Ala Thr 
    210                 215                 220                 


Gly Cys Cys Ala Thr Ala Cys Thr Thr Thr Gly Thr Thr Thr Gly Ala 
225                 230                 235                 240 


Thr Ala Gly Ala Ala Gly Ala Ala Ala Gly Thr Ala Ala Gly Gly Cys 
                245                 250                 255     


Ala Cys Ala Gly Ala Ala Ala Ala Cys Thr Thr Gly Ala Gly Thr Ala 
            260                 265                 270         


Cys Cys Thr Thr Ala Thr Thr Thr Thr Thr Ala Ala Ala Ala Cys Thr 
        275                 280                 285             


Gly Cys Ala Thr Thr Ala Gly Gly Ala Thr Thr Ala Ala Ala Ala Gly 
    290                 295                 300                 


Gly Thr Thr Ala Gly Cys Cys Cys Cys Thr Ala Thr Ala Thr Cys Cys 
305                 310                 315                 320 


Ala Ala Gly Thr Ala Thr Thr Gly Gly Thr Cys Thr Gly Ala Gly Ala 
                325                 330                 335     


Thr Cys Cys Cys Ala Thr Thr Thr Cys Thr Ala Gly Ala Ala Thr Thr 
            340                 345                 350         


Cys Thr Gly Ala Ala Ala Thr Cys Cys Ala Ala Ala Ala Ala Gly Cys 
        355                 360                 365             


Thr Cys Thr Gly Ala Ala Ala Ala Thr Cys Ala Ala Thr Ala Gly Thr 
    370                 375                 380                 


Thr Ala Thr Thr Thr Thr Thr Cys Cys Ala Ala Ala Thr Gly Thr Ala 
385                 390                 395                 400 


Thr Thr Cys Ala Thr Thr Gly Thr Gly Gly Thr Ala Ala Ala Ala Thr 
                405                 410                 415     


Ala Cys Ala Cys Cys Ala Ala Thr Ala Thr Ala Ala Ala Ala Thr Thr 
            420                 425                 430         


Thr Ala Cys Cys Ala Thr Cys Thr Thr Ala Ala Cys Cys Ala Cys Thr 
        435                 440                 445             


Thr Thr Thr Ala Ala Gly Thr Gly Thr Gly Thr Thr Ala Thr Ala Ala 
    450                 455                 460                 


Ala Thr Ala Cys Ala Thr Thr Cys Ala Thr Gly Cys Thr Ala Cys Cys 
465                 470                 475                 480 


Ala Thr Cys Ala Cys Thr Ala Gly Cys Ala Thr Cys Cys Ala Thr Cys 
                485                 490                 495     


Thr Cys Thr Gly Gly Ala Ala Cys Thr Cys Thr Thr Thr Thr Cys Ala 
            500                 505                 510         


Thr Cys Thr Thr Gly Cys Ala Ala Ala Ala Cys Thr Gly Cys Ala Ala 
        515                 520                 525             


Thr Thr Cys Thr Ala Thr Ala Cys Cys Cys Ala Thr Thr Ala Ala Ala 
    530                 535                 540                 


Cys Ala Ala Thr Gly Ala Cys Cys Cys Ala 
545                 550                 


