                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
       Dana Farber Cancer Instititute, Inc.
 
<120>  FUSION PROTEINS FOR TREATING CANCER AND RELATED METHODS

<130>  H0498.70513WO00

<150>  US 61/986,866
<151>  2014-04-30

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asn Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Lys Leu Leu Ile Tyr Glu Gly Asn Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Ser Trp Asn Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser 
                245                 250                 255     


Ser Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
            260                 265                 270         


Ser Glu Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        275                 280                 285             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe 
    290                 295                 300                 


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
305                 310                 315                 320 


Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu 
                325                 330                 335     


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            340                 345                 350         


Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Thr Glu Leu Tyr Gln 
        355                 360                 365             


Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu 
    370                 375                 380                 


Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr 
385                 390                 395                 400 


Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                405                 410                 415     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            420                 425                 430         


Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu His His His His His 
        435                 440                 445             


His 
    


<210>  2
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asn Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Lys Leu Leu Ile Tyr Glu Gly Asn Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Ser Trp Asn Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser 
                245                 250                 255     


Ser Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
            260                 265                 270         


Ser Glu Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        275                 280                 285             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe 
    290                 295                 300                 


Ser Cys Ala Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
305                 310                 315                 320 


Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu 
                325                 330                 335     


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            340                 345                 350         


Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Thr Glu Leu Tyr Gln 
        355                 360                 365             


Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu 
    370                 375                 380                 


Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr 
385                 390                 395                 400 


Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                405                 410                 415     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            420                 425                 430         


Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu His His His His His 
        435                 440                 445             


His 
    


<210>  3
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asn Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Lys Leu Leu Ile Tyr Glu Gly Asn Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Ser Trp Asn Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser 
                245                 250                 255     


Ser Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
            260                 265                 270         


Ser Glu Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        275                 280                 285             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe 
    290                 295                 300                 


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
305                 310                 315                 320 


Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu 
                325                 330                 335     


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            340                 345                 350         


Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Thr Glu Leu Tyr Gln 
        355                 360                 365             


Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu 
    370                 375                 380                 


Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr 
385                 390                 395                 400 


Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                405                 410                 415     


Ala Trp Glu Val Val Ala Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            420                 425                 430         


Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu His His His His His 
        435                 440                 445             


His 
    


<210>  4
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asn Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Lys Leu Leu Ile Tyr Glu Gly Asn Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Ser Trp Asn Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser 
                245                 250                 255     


Ser Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
            260                 265                 270         


Ser Glu Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        275                 280                 285             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe 
    290                 295                 300                 


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
305                 310                 315                 320 


Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Ala 
                325                 330                 335     


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            340                 345                 350         


Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Thr Glu Leu Tyr Gln 
        355                 360                 365             


Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu 
    370                 375                 380                 


Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr 
385                 390                 395                 400 


Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                405                 410                 415     


Ala Trp Glu Val Val Arg Ala Glu Ile Ala Arg Ser Phe Ser Leu Ser 
            420                 425                 430         


Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu His His His His His 
        435                 440                 445             


His 
    


<210>  5
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asn Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Lys Leu Leu Ile Tyr Glu Gly Asn Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln Ser Trp Asn Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser 
                245                 250                 255     


Ser Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
            260                 265                 270         


Ser Glu Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
        275                 280                 285             


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe 
    290                 295                 300                 


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
305                 310                 315                 320 


Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu Ala Glu 
                325                 330                 335     


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            340                 345                 350         


Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Thr Glu Leu Tyr Gln 
        355                 360                 365             


Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu 
    370                 375                 380                 


Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr 
385                 390                 395                 400 


Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                405                 410                 415     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Ala Ser Phe Ser Leu Ser 
            420                 425                 430         


Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu His His His His His 
        435                 440                 445             


His 
    


<210>  6
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
gaagttcaat tggttgagtc tggtggaggt ttggttcaac caggaggttc cttgagattg       60

tcatgtaaag tttctggttt tactttctct tcctatggaa tgtcttgggt tagacaagct      120

cctggaaagg gtttggaatg ggttgcttcc atctcaaccg gtggttacaa cacatattac      180

gctgattccg ttaaaggtag attcactatc tccagagata actctaagaa cactttgtat      240

ttgcaaatga actctttgag agctgaagat actgctgttt actattgtgc gcgcggttac      300

tctccatatt cttacgctat ggattattgg ggtcaaggta ctactgttac tgtttctggt      360

ggaggtggag gttcaggagg tggaggaagt ggaggaggtg gatcagacat ccagatgaca      420

caatcaccat cttccttgtc agcttctgtt ggagatagag ttactattac atgtagagct      480

tccactgaca tcgataacga catgaattgg tatcagcaaa aacctggaca ggcgccaaag      540

ttgttgatct acgagggtaa ctcattgcaa tctggagttc cttccagatt ttcatcttcc      600

ggttccggaa cagatttcac tttgacaatc tcttccttgc agccagaaga ctttgctact      660

tattactgtt tgcaatcatg gaatgttcct ttgacattcg gtcaaggaac taaattggag      720

attaagggtg aaggagggtc aggtgaaggt tcctccggtg agggttcctc atccgaaggg      780

ggaggatctg aaggcggtgg ctctgagggt ggaggttcag agggagggtc atgtgacttg      840

cctcaaactc attctttggg ttctagaaga actttgatgt tgttggctca aatgagaaga      900

atctctcctt tctcttgttt gaaggacaga catgacttcg gtttccctca agaggagttc      960

gacggtaacc aattccaaaa ggctcaagct atctctgtct tgcatgagat gatccaacaa     1020

atcttcaact tgttctctac taaggactct tctgctgctt gggacgagac tttgttggag     1080

aagttctaca ctgagttgta ccaacaattg aacgacttgg aggcttgtgt cactcaagag     1140

gtcggtgtcg aggagactcc tttgatgaac gaggactcta tcttggctgt caagaagtac     1200

ttccaaagaa tcactttgta cttgactgag aagaagtact ctccttgtgc ttgggaggtc     1260

gtcagagctg agatcatgag atctttctct ttgtctacta acttgcaaga gagattgaga     1320

agaaaggagc atcaccatca ccatcactaa                                      1350


<210>  7
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
gaagttcaat tggttgagtc tggtggaggt ttggttcaac caggaggttc cttgagattg       60

tcatgtaaag tttctggttt tactttctct tcctatggaa tgtcttgggt tagacaagct      120

cctggaaagg gtttggaatg ggttgcttcc atctcaaccg gtggttacaa cacatattac      180

gctgattccg ttaaaggtag attcactatc tccagagata actctaagaa cactttgtat      240

ttgcaaatga actctttgag agctgaagat actgctgttt actattgtgc gcgcggttac      300

tctccatatt cttacgctat ggattattgg ggtcaaggta ctactgttac tgtttctggt      360

ggaggtggag gttcaggagg tggaggaagt ggaggaggtg gatcagacat ccagatgaca      420

caatcaccat cttccttgtc agcttctgtt ggagatagag ttactattac atgtagagct      480

tccactgaca tcgataacga catgaattgg tatcagcaaa aacctggaca ggcgccaaag      540

ttgttgatct acgagggtaa ctcattgcaa tctggagttc cttccagatt ttcatcttcc      600

ggttccggaa cagatttcac tttgacaatc tcttccttgc agccagaaga ctttgctact      660

tattactgtt tgcaatcatg gaatgttcct ttgacattcg gtcaaggaac taaattggag      720

attaagggtg aaggagggtc aggtgaaggt tcctccggtg agggttcctc atccgaaggg      780

ggaggatctg aaggcggtgg ctctgagggt ggaggttcag agggagggtc atgtgacttg      840

cctcaaactc attctttggg ttctagaaga actttgatgt tgttggctca aatgagaaga      900

atctctcctt tctcttgtgc taaggacaga catgacttcg gtttccctca agaggagttc      960

gacggtaacc aattccaaaa ggctcaagct atctctgtct tgcatgagat gatccaacaa     1020

atcttcaact tgttctctac taaggactct tctgctgctt gggacgagac tttgttggag     1080

aagttctaca ctgagttgta ccaacaattg aacgacttgg aggcttgtgt cactcaagag     1140

gtcggtgtcg aggagactcc tttgatgaac gaggactcta tcttggctgt caagaagtac     1200

ttccaaagaa tcactttgta cttgactgag aagaagtact ctccttgtgc ttgggaggtc     1260

gtcagagctg agatcatgag atctttctct ttgtctacta acttgcaaga gagattgaga     1320

agaaaggagc atcaccatca ccatcactaa                                      1350


<210>  8
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
gaagttcaat tggttgagtc tggtggaggt ttggttcaac caggaggttc cttgagattg       60

tcatgtaaag tttctggttt tactttctct tcctatggaa tgtcttgggt tagacaagct      120

cctggaaagg gtttggaatg ggttgcttcc atctcaaccg gtggttacaa cacatattac      180

gctgattccg ttaaaggtag attcactatc tccagagata actctaagaa cactttgtat      240

ttgcaaatga actctttgag agctgaagat actgctgttt actattgtgc gcgcggttac      300

tctccatatt cttacgctat ggattattgg ggtcaaggta ctactgttac tgtttctggt      360

ggaggtggag gttcaggagg tggaggaagt ggaggaggtg gatcagacat ccagatgaca      420

caatcaccat cttccttgtc agcttctgtt ggagatagag ttactattac atgtagagct      480

tccactgaca tcgataacga catgaattgg tatcagcaaa aacctggaca ggcgccaaag      540

ttgttgatct acgagggtaa ctcattgcaa tctggagttc cttccagatt ttcatcttcc      600

ggttccggaa cagatttcac tttgacaatc tcttccttgc agccagaaga ctttgctact      660

tattactgtt tgcaatcatg gaatgttcct ttgacattcg gtcaaggaac taaattggag      720

attaagggtg aaggagggtc aggtgaaggt tcctccggtg agggttcctc atccgaaggg      780

ggaggatctg aaggcggtgg ctctgagggt ggaggttcag agggagggtc atgtgacttg      840

cctcaaactc attctttggg ttctagaaga actttgatgt tgttggctca aatgagaaga      900

atctctcctt tctcttgttt gaaggacaga catgacttcg gtttccctca agaggagttc      960

gacggtaacc aattccaaaa ggctcaagct atctctgtct tgcatgagat gatccaacaa     1020

atcttcaact tgttctctac taaggactct tctgctgctt gggacgagac tttgttggag     1080

aagttctaca ctgagttgta ccaacaattg aacgacttgg aggcttgtgt cactcaagag     1140

gtcggtgtcg aggagactcc tttgatgaac gaggactcta tcttggctgt caagaagtac     1200

ttccaaagaa tcactttgta cttgactgag aagaagtact ctccttgtgc ttgggaggtc     1260

gtcgctgctg agatcatgag atctttctct ttgtctacta acttgcaaga gagattgaga     1320

agaaaggagc atcaccatca ccatcactaa                                      1350


<210>  9
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
gaagttcaat tggttgagtc tggtggaggt ttggttcaac caggaggttc cttgagattg       60

tcatgtaaag tttctggttt tactttctct tcctatggaa tgtcttgggt tagacaagct      120

cctggaaagg gtttggaatg ggttgcttcc atctcaaccg gtggttacaa cacatattac      180

gctgattccg ttaaaggtag attcactatc tccagagata actctaagaa cactttgtat      240

ttgcaaatga actctttgag agctgaagat actgctgttt actattgtgc gcgcggttac      300

tctccatatt cttacgctat ggattattgg ggtcaaggta ctactgttac tgtttctggt      360

ggaggtggag gttcaggagg tggaggaagt ggaggaggtg gatcagacat ccagatgaca      420

caatcaccat cttccttgtc agcttctgtt ggagatagag ttactattac atgtagagct      480

tccactgaca tcgataacga catgaattgg tatcagcaaa aacctggaca ggcgccaaag      540

ttgttgatct acgagggtaa ctcattgcaa tctggagttc cttccagatt ttcatcttcc      600

ggttccggaa cagatttcac tttgacaatc tcttccttgc agccagaaga ctttgctact      660

tattactgtt tgcaatcatg gaatgttcct ttgacattcg gtcaaggaac taaattggag      720

attaagggtg aaggagggtc aggtgaaggt tcctccggtg agggttcctc atccgaaggg      780

ggaggatctg aaggcggtgg ctctgagggt ggaggttcag agggagggtc atgtgacttg      840

cctcaaactc attctttggg ttctagaaga actttgatgt tgttggctca aatgagaaga      900

atctctcctt tctcttgttt gaaggacaga catgacttcg gtttccctca agaggagttc      960

gacggtaacc aattccaaaa ggctcaagct atctctgtct tgcatgcgat gatccaacaa     1020

atcttcaact tgttctctac taaggactct tctgctgctt gggacgagac tttgttggag     1080

aagttctaca ctgagttgta ccaacaattg aacgacttgg aggcttgtgt cactcaagag     1140

gtcggtgtcg aggagactcc tttgatgaac gaggactcta tcttggctgt caagaagtac     1200

ttccaaagaa tcactttgta cttgactgag aagaagtact ctccttgtgc ttgggaggtc     1260

gtcagagctg agatcgcgag atctttctct ttgtctacta acttgcaaga gagattgaga     1320

agaaaggagc atcaccatca ccatcactaa                                      1350


<210>  10
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
gaagttcaat tggttgagtc tggtggaggt ttggttcaac caggaggttc cttgagattg       60

tcatgtaaag tttctggttt tactttctct tcctatggaa tgtcttgggt tagacaagct      120

cctggaaagg gtttggaatg ggttgcttcc atctcaaccg gtggttacaa cacatattac      180

gctgattccg ttaaaggtag attcactatc tccagagata actctaagaa cactttgtat      240

ttgcaaatga actctttgag agctgaagat actgctgttt actattgtgc gcgcggttac      300

tctccatatt cttacgctat ggattattgg ggtcaaggta ctactgttac tgtttctggt      360

ggaggtggag gttcaggagg tggaggaagt ggaggaggtg gatcagacat ccagatgaca      420

caatcaccat cttccttgtc agcttctgtt ggagatagag ttactattac atgtagagct      480

tccactgaca tcgataacga catgaattgg tatcagcaaa aacctggaca ggcgccaaag      540

ttgttgatct acgagggtaa ctcattgcaa tctggagttc cttccagatt ttcatcttcc      600

ggttccggaa cagatttcac tttgacaatc tcttccttgc agccagaaga ctttgctact      660

tattactgtt tgcaatcatg gaatgttcct ttgacattcg gtcaaggaac taaattggag      720

attaagggtg aaggagggtc aggtgaaggt tcctccggtg agggttcctc atccgaaggg      780

ggaggatctg aaggcggtgg ctctgagggt ggaggttcag agggagggtc atgtgacttg      840

cctcaaactc attctttggg ttctagaaga actttgatgt tgttggctca aatgagaaga      900

atctctcctt tctcttgttt gaaggacaga catgacttcg gtttccctca agaggagttc      960

gacggtaacc aattccaaaa ggctcaagct atctctgtct tggctgagat gatccaacaa     1020

atcttcaact tgttctctac taaggactct tctgctgctt gggacgagac tttgttggag     1080

aagttctaca ctgagttgta ccaacaattg aacgacttgg aggcttgtgt cactcaagag     1140

gtcggtgtcg aggagactcc tttgatgaac gaggactcta tcttggctgt caagaagtac     1200

ttccaaagaa tcactttgta cttgactgag aagaagtact ctccttgtgc ttgggaggtc     1260

gtcagagctg agatcatggc atctttctct ttgtctacta acttgcaaga gagattgaga     1320

agaaaggagc atcaccatca ccatcactaa                                      1350


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Gly Gly Gly Ser Glu 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Gly Ser Glu Ser Gly 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Gly Ser Glu Gly Ser 
1               5   


<210>  14
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Gly Glu Gly Gly Ser Gly Glu Gly Ser Ser Gly Glu Gly Ser Ser Ser 
1               5                   10                  15      


Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser 
        115                 


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Asp Ile Asp Asn Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Lys Gly Asn Tyr Val Val Thr Asp His 
1               5                   


<210>  18
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
agagaggctg aagct                                                        15


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Arg Glu Ala Glu Ala 
1               5   


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
catcaccatc accatcacta a                                                 21


<210>  22
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
gtttgtagcc                                                              10


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Glu Glu Phe Gly Asn Gln 
1               5       


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Glu Glu Phe Asp Gly Asn Gln 
1               5           


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Gly Glu Gly Gly Ser 
1               5   


<210>  26
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
ggtgaaggag ggtcaggtga aggttcctcc ggtgagggtt cctcatccga agggggagga       60

tctgaaggcg gtggctctga gggtggaggt tcagagggag ggtca                      105


<210>  27
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Gly Glu Gly Gly Ser Glu Gly Gly Ser Glu Gly Ser Gly Glu Ser Ser 
1               5                   10                  15      


Gly Glu Gly Gly Ser Glu Gly Ser Gly Glu Ser Gly Gly Glu Ser Gly 
            20                  25                  30          


Gly Glu Ser 
        35  


<210>  28
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
ggtgaaggag ggtcagaagg aggttccgag ggttctggtg aatcatccgg agaaggagga       60

tctgaaggct caggcgagtc tggtggagag tcagggggag agtca                      105


<210>  29
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Glu Phe Pro Gln Glu Glu Phe Asp Asp Lys Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Leu Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Glu Phe Tyr Ile Glu Leu Asp Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ser Cys Val Met Gln Glu Val Gly Val Ile Glu Ser Pro Leu Met 
            100                 105                 110         


Tyr Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Ser Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Ile Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Lys Ser Lys Glu 
                165   


<210>  30
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  31
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  31

Cys Asp Leu Pro Glu Thr His Ser Leu Asp Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Ser Arg Ile Ser Pro Ser Ser Cys Leu Met Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Pro Ala Ile Ser Val Leu His Glu Leu Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Asp 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Ala Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  32
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Asp Leu Pro Gln Thr His Ser Leu Ser Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Ile Met Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Thr Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Met Met Gln Glu Val Gly Val Glu Asp Thr Pro Leu Met 
            100                 105                 110         


Asn Val Asp Ser Ile Leu Thr Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Ala Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  33
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  33

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Thr Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Asn Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Val Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Lys Ile Phe Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  34
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser His Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Glu Glu Glu Phe Asp Gly His Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  35
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Leu Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Thr Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asn Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Met Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  36
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Asp Leu Pro Gln Thr His Ser Leu Gly His Arg Arg Thr Met Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Arg Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Glu Ala Ile Ser Val Leu His Glu Val Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Val Ala Trp Asp Glu Arg 
65                  70                  75                  80  


Leu Leu Asp Lys Leu Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Val Trp Val Gly Gly Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Glu 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Glu 
                165     


<210>  37
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  37

Cys Asn Leu Ser Gln Thr His Ser Leu Asn Asn Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Met Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Glu Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Met Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asn Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Tyr Ile Glu Leu Phe Gln Gln Met Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Met Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  38
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Gly Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Arg Ile Pro Gln Glu Glu Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp Glu Gln Ser 
65                  70                  75                  80  


Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Ile Glu Arg Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Arg Leu Arg Arg Lys Asp 
                165     


<210>  39
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  39

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Asn 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  40
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu Ile 
1               5                   10                  15      


Leu Leu Ala Gln Met Gly Arg Ile Ser His Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Tyr Asp Phe Gly Phe Pro Gln Glu Val Phe Asp Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Ser Ala Phe His Glu Met Ile Gln Gln Thr 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Ile Glu Leu Phe Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu Glu Ile Ala Leu Met 
            100                 105                 110         


Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Met Gly Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Phe Ser Thr Asn Leu Gln Lys 
145                 150                 155                 160 


Gly Leu Arg Arg Lys Asp 
                165     


  


