                         SEQUENCE LISTING

<110>  Emory University
       Herrin, Brantley R.
       Cooper, Max Dale
       Ehrhardt, Rudolf
 
<120>  HUMANIZED VARIABLE LYMPHOCYTE RECEPTORS (VLR) AND COMPOSITIONS 
       AND USES RELATED THERETO

<130>  13203 PCT

<150>  US 61/987,566
<151>  2014-05-02

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Thr Val Asp Cys Arg Ser 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Ile 
            20                  25                  30          


Ile Tyr Leu His Asp Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Glu Ile Tyr Leu Gly Ser Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Val 
65                  70                  75                  80  


Leu Asp Leu Gly Thr Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Glu Leu Phe Leu Cys Cys Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn His 
        115                 120                 125             


Leu Ala Leu Asp Gln Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Tyr Leu Phe Gly Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Ile Ala 
                165                 170                 175     


Met Arg Trp Asp Gly Lys Ala Val Asn Asp Pro Asp Ser Ala Arg Cys 
            180                 185                 190         


Thr Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser 
        195                 200                 205             


Lys Lys Phe Arg Cys 
    210             


<210>  2
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Gly Ser Leu His Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val 
1               5                   10                  15      


Asp Cys Arg Gly Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu 
            20                  25                  30          


Thr Ile Thr Glu Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro 
        35                  40                  45              


Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser 
    50                  55                  60                  


Asn Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Asn Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro 
                85                  90                  95      


Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn 
            100                 105                 110         


Ala Asn Lys Ile Asn Xaa Leu Arg Val Asp Ala Phe Gln Asp Leu His 
        115                 120                 125             


Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala 
    130                 135                 140                 


Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala 
145                 150                 155                 160 


Gln Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr 
                165                 170                 175     


Leu His Thr Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro 
            180                 185                 190         


Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe 
        195                 200                 205             


Arg Cys Ser Ala Ala Ala His His His His His His 
    210                 215                 220 


<210>  3
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Ile Tyr Leu His Asp 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ile Tyr Leu Gly Ser 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Leu Asp Leu Gly Thr 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Leu Phe Leu Cys Cys 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  7

His Leu Ala Leu Asp Gln 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  8

His Met Tyr Leu Phe Gly 
1               5       


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Ala Met Arg Trp Asp Gly Lys Ala Val Asn Asp Pro Asp Ser 
1               5                   10                  15  


<210>  10
<211>  213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (11)..(13)
<223>  Where X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  Where X is any amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (175)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa 
            20                  25                  30          


Ile Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Arg Cys 
            180                 185                 190         


Thr Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser 
        195                 200                 205             


Lys Lys Phe Arg Cys 
    210             


<210>  11
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Val Asp Cys Arg Gly 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ile Arg Leu Glu Gln 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Ile Asp Leu Ser Asn 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Leu Val Leu Tyr Gly 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Leu Leu Leu Asn Ala 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Leu Leu Ser Leu Tyr Asp 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Met His Leu Ala Gln 
1               5       


<210>  18
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  19
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Thr Val 
225                 230                 235                 240 


Asp Cys Arg Ser Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu 
                245                 250                 255     


Thr Ile Thr Ile Ile Tyr Leu His Asp Asn Thr Ile Lys Val Ile Pro 
            260                 265                 270         


Pro Gly Ala Phe Ser Pro Tyr Lys Lys Leu Arg Glu Ile Tyr Leu Gly 
        275                 280                 285             


Ser Asn Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg 
    290                 295                 300                 


Ser Leu Asn Val Leu Asp Leu Gly Thr Asn Lys Ile Thr Glu Leu Pro 
305                 310                 315                 320 


Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu Gln Glu Leu Phe Leu Cys 
                325                 330                 335     


Cys Asn Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His 
            340                 345                 350         


Asn Leu Asn His Leu Ala Leu Asp Gln Asn Lys Leu Gln Thr Ile Ala 
        355                 360                 365             


Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln His Met Tyr Leu Phe 
    370                 375                 380                 


Gly Asn Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr 
385                 390                 395                 400 


Leu His Ile Ala Met Arg Trp Asp Gly Lys Ala Val Asn Asp Pro Asp 
                405                 410                 415     


Ser Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly 
            420                 425                 430         


Gln Ile Lys Ser Lys Lys Phe Arg Cys 
        435                 440     


<210>  20
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Thr Val Asp Cys Arg 
1               5                   10                  15      


Ser Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr 
            20                  25                  30          


Ile Ile Tyr Leu His Asp Asn Thr Ile Lys Val Ile Pro Pro Gly Ala 
        35                  40                  45              


Phe Ser Pro Tyr Lys Lys Leu Arg Glu Ile Tyr Leu Gly Ser Asn Gln 
    50                  55                  60                  


Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn 
65                  70                  75                  80  


Val Leu Asp Leu Gly Thr Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu 
                85                  90                  95      


Phe Glu Gly Leu Phe Ser Leu Gln Glu Leu Phe Leu Cys Cys Asn Lys 
            100                 105                 110         


Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn 
        115                 120                 125             


His Leu Ala Leu Asp Gln Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr 
    130                 135                 140                 


Phe Ser Pro Leu Arg Ala Ile Gln His Met Tyr Leu Phe Gly Asn Pro 
145                 150                 155                 160 


Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Ile 
                165                 170                 175     


Ala Met Arg Trp Asp Gly Lys Ala Val Asn Asp Pro Asp Ser Ala Arg 
            180                 185                 190         


Cys Thr Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys 
        195                 200                 205             


Ser Lys Lys Phe Arg Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser 
        435     


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Xaa Xaa Leu Xaa Leu Xaa Xaa 
1               5           


<210>  22
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Cys Pro Xaa Xaa Cys Thr Cys Ser Xaa Asn Xaa Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Xaa Xaa 
            


<210>  23
<211>  47
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Xaa Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr 
1               5                   10                  15      


Phe Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro 
            20                  25                  30          


Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His 
        35                  40                  45          


<210>  24
<211>  213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Asp Leu Gly Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Xaa Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
        115                 120                 125             


Leu Ser Leu Asp Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Ser Ile Ala 
                165                 170                 175     


Met Arg Trp Asp Gly Lys Ala Val Asn Asp Pro Asp Ser Ala Arg Cys 
            180                 185                 190         


Thr Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser 
        195                 200                 205             


Lys Lys Phe Arg Cys 
    210             


<210>  25
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Val Xaa Cys Xaa Xaa Xaa Xaa Leu Xaa Ser Val Pro Ala Xaa Ile Pro 
1               5                   10                  15      


Thr Thr Thr Xaa Xaa Leu Xaa Xaa Xaa Xaa Asn Xaa Ile Thr Lys Xaa 
            20                  25                  30          


Xaa Pro Gly Val Phe Asp Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Xaa Leu 
        35                  40                  45              


Xaa Xaa Asn Xaa Leu Xaa Xaa Xaa Pro Xaa Gly Xaa Phe Asp 
    50                  55                  60          


<210>  26
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa 
            20                  25                  30          


Ile Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys 
        195                 200                 205             


Lys Phe Arg Cys 
    210         


<210>  27
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa 
            20                  25                  30          


Ile Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  28
<211>  197
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(187)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr Ser Pro 
            180                 185                 190         


Arg Arg Leu Ala Asn 
        195         


<210>  29
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  30
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Xaa Leu Xaa Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  31
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  32
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa 
        115                 120                 125             


Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  33
<211>  182
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (91)..(92)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (115)..(116)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(172)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa Ile 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe Ser 
            20                  25                  30          


Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile Ser 
        35                  40                  45              


Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa Leu 
    50                  55                  60                  


Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe Glu 
65                  70                  75                  80  


Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn 
                85                  90                  95      


Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa Leu 
            100                 105                 110         


Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser 
        115                 120                 125             


Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe Ile 
    130                 135                 140                 


Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr Ser 
                165                 170                 175     


Pro Arg Arg Leu Ala Asn 
            180         


<210>  34
<211>  153
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(143)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Ala Phe Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn 
1               5                   10                  15      


Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu 
            20                  25                  30          


Asn Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser 
        35                  40                  45              


Leu Phe Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn 
    50                  55                  60                  


Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu 
65                  70                  75                  80  


Asn Xaa Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly 
                85                  90                  95      


Thr Phe Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa Asn 
            100                 105                 110         


Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg 
    130                 135                 140                 


Cys Thr Ser Pro Arg Arg Leu Ala Asn 
145                 150             


<210>  35
<211>  129
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(119)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa Leu Xaa Leu Xaa Xaa Asn 
1               5                   10                  15      


Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu 
            20                  25                  30          


Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn Cys Leu Arg Val Asp 
        35                  40                  45              


Ala Phe Gln Asp Leu His Asn Leu Asn Xaa Leu Xaa Leu Xaa Xaa Asn 
    50                  55                  60                  


Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile 
65                  70                  75                  80  


Gln Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe Ile Cys Asp Cys His Leu 
                85                  90                  95      


Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr Ser Pro Arg Arg Leu Ala 
        115                 120                 125             


Asn 
    


<210>  36
<211>  76
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(76)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Xaa Leu Xaa Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe Glu 
1               5                   10                  15      


Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn 
            20                  25                  30          


Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Xaa Leu 
        35                  40                  45              


Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser 
    50                  55                  60                  


Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa 
65                  70                  75      


<210>  37
<211>  54
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn Cys Leu Arg Val Asp Ala 
1               5                   10                  15      


Phe Gln Asp Leu His Asn Leu Asn Xaa Leu Xaa Leu Xaa Xaa Asn Lys 
            20                  25                  30          


Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln 
        35                  40                  45              


Xaa Met Xaa Leu Xaa Xaa 
    50                  


<210>  38
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Xaa Leu Xaa Leu Xaa Xaa Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr 
1               5                   10                  15      


Phe Ser Pro Leu Arg Ala Ile Gln Xaa Met Xaa Leu Xaa Xaa 
            20                  25                  30  


<210>  39
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa 
            20                  25                  30          


Ile Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys 
        195                 200                 205             


Lys Phe Arg Cys 
    210         


<210>  40
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa 
            20                  25                  30          


Ile Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  41
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  42
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  43
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Xaa Leu Xaa Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  44
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(188)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr Ser 
            180                 185                 190         


Pro Arg Arg Leu Ala Asn 
        195             


<210>  45
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  46
<211>  182
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (91)..(92)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(172)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Xaa Ile 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe Ser 
            20                  25                  30          


Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn Gln Ile Ser 
        35                  40                  45              


Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa Leu 
    50                  55                  60                  


Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe Glu 
65                  70                  75                  80  


Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn 
                85                  90                  95      


Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr Leu 
            100                 105                 110         


Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser 
        115                 120                 125             


Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe Ile 
    130                 135                 140                 


Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr Ser 
                165                 170                 175     


Pro Arg Arg Leu Ala Asn 
            180         


<210>  47
<211>  153
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(143)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Ala Phe Ser Pro Tyr Lys Lys Leu Arg Xaa Ile Xaa Xaa Xaa Xaa Asn 
1               5                   10                  15      


Gln Ile Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu 
            20                  25                  30          


Asn Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Thr Glu Leu Pro Lys Ser 
        35                  40                  45              


Leu Phe Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn 
    50                  55                  60                  


Lys Ile Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu 
65                  70                  75                  80  


Asn Tyr Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly 
                85                  90                  95      


Thr Phe Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn 
            100                 105                 110         


Pro Phe Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg 
    130                 135                 140                 


Cys Thr Ser Pro Arg Arg Leu Ala Asn 
145                 150             


<210>  48
<211>  129
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(119)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Ala Phe Gln Gly Leu Arg Ser Leu Asn Xaa Leu Xaa Leu Xaa Xaa Asn 
1               5                   10                  15      


Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe Glu Gly Leu Phe Ser Leu 
            20                  25                  30          


Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn Cys Leu Arg Val Asp 
        35                  40                  45              


Ala Phe Gln Asp Leu His Asn Leu Asn Tyr Leu Asp Leu Asn Asn Asn 
    50                  55                  60                  


Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile 
65                  70                  75                  80  


Gln His Met Trp Leu Tyr Xaa Asn Pro Phe Ile Cys Asp Cys His Leu 
                85                  90                  95      


Lys Trp Leu Ala Asp Tyr Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Cys Thr Ser Pro Arg Arg Leu Ala 
        115                 120                 125             


Asn 
    


<210>  49
<211>  93
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Leu Xaa Leu Xaa Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
1               5                   10                  15      


Glu Gly Leu Phe Ser Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile 
            20                  25                  30          


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        35                  40                  45              


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    50                  55                  60                  


Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe 
65                  70                  75                  80  


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu 
                85                  90              


<210>  50
<211>  72
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Leu Gln Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn Cys Leu Arg Val 
1               5                   10                  15      


Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr Leu Asp Leu Asn Asn 
            20                  25                  30          


Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala 
        35                  40                  45              


Ile Gln His Met Trp Leu Tyr Xaa Asn Pro Phe Ile Cys Asp Cys His 
    50                  55                  60                  


Leu Lys Trp Leu Ala Asp Tyr Leu 
65                  70          


<210>  51
<211>  55
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Ala Phe Gln Asp Leu His Asn Leu Asn Tyr Leu Asp Leu Asn Asn Asn 
1               5                   10                  15      


Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile 
            20                  25                  30          


Gln His Met Trp Leu Tyr Xaa Asn Pro Phe Ile Cys Asp Cys His Leu 
        35                  40                  45              


Lys Trp Leu Ala Asp Tyr Leu 
    50                  55  


<210>  52
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Tyr Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Leu 
1               5                   10                  15      


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  54
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly 
1               5                   10                  15      


Val Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala 
            20                  25                  30          


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        35                  40                  45              


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    50                  55                  60                  


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
65                  70                  75                  80  


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                85                  90                  95      


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            100                 105                 110         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        115                 120                 125             


Leu His Met Gln 
    130         


<210>  55
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly 
1               5                   10                  15      


Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys 
            20                  25                  30          


Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu 
        35                  40                  45              


Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu 
    50                  55                  60          


<210>  56
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Cys Pro Ser Gln Cys Ser Cys Pro Gly Thr Asp Val Asn Cys His 
1               5                   10                  15      


Glu Arg Arg Leu Ala Ser Val Pro Ala Glu Ile Pro Thr Thr Thr Lys 
            20                  25                  30          


Ile Leu Arg Leu Tyr Ile Asn Gln Ile Thr Lys Leu Glu Pro Gly Val 
        35                  40                  45              


Phe Asp Arg Leu Thr Gln Leu Thr Gln Leu Gly Leu Trp Asp Asn Gln 
    50                  55                  60                  


Leu Gln Ala Leu Pro Glu Gly Val Phe Asp Arg Leu Val Asn Leu Gln 
65                  70                  75                  80  


Lys Leu Tyr Leu Asn Gln Asn Gln Leu Leu Ala Leu Pro Val Gly Val 
                85                  90                  95      


Phe Asp Lys Leu Thr Gln Leu Thr Tyr Leu Asp Leu Asn Asn Asn Gln 
            100                 105                 110         


Leu Lys Ser Ile Pro Arg Gly Ala Phe Asp Asn Leu Lys Ser Leu Thr 
        115                 120                 125             


His Ile Trp Leu Tyr Gly Asn Pro Trp Asp Cys Glu Cys Ser Asp Ile 
    130                 135                 140                 


Leu Tyr Leu Lys Asn Trp Ile Val Gln His Ala Ser Ile Val Asn Pro 
145                 150                 155                 160 


His Pro Tyr Gly Gly Val Asp Asn Val Lys Cys Ser Gly Thr Asn Thr 
                165                 170                 175     


Pro Val Arg Ala Val Thr Glu Ala Ser Thr Ser Pro Ser Lys Cys Pro 
            180                 185                 190         


Gly 
    


<210>  57
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Trp Ile Lys Trp Ile Ala Thr Leu Val Ala Phe Gly Ala Leu Val 
1               5                   10                  15      


Gln Ser Ala Val Ala Cys Pro Ser Gln Cys Ser Cys Pro Gly Thr Asp 
            20                  25                  30          


Val Asn Cys His Glu Arg Arg Leu Ala Ser Val Pro Ala Glu Ile Pro 
        35                  40                  45              


Thr Thr Thr Lys Ile Leu Arg Leu Tyr Ile Asn Gln Ile Thr Lys Leu 
    50                  55                  60                  


Glu Pro Gly Val Phe Asp Arg Leu Thr Gln Leu Thr Gln Leu Gly Leu 
65                  70                  75                  80  


Trp Asp Asn Gln Leu Gln Ala Leu Pro Glu Gly Val Phe Asp Arg Leu 
                85                  90                  95      


Val Asn Leu Gln Lys Leu Tyr Leu Asn Gln Asn Gln Leu Leu Ala Leu 
            100                 105                 110         


Pro Val Gly Val Phe Asp Lys Leu Thr Gln Leu Thr Tyr Leu Asp Leu 
        115                 120                 125             


Asn Asn Asn Gln Leu Lys Ser Ile Pro Arg Gly Ala Phe Asp Asn Leu 
    130                 135                 140                 


Lys Ser Leu Thr His Ile Trp Leu Tyr Gly Asn Pro Trp Asp Cys Glu 
145                 150                 155                 160 


Cys Ser Asp Ile Leu Tyr Leu Lys Asn Trp Ile Val Gln His Ala Ser 
                165                 170                 175     


Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Val Lys Cys Ser 
            180                 185                 190         


Gly Thr Asn Thr Pro Val Arg Ala Val Thr Glu Ala Ser Thr Ser Pro 
        195                 200                 205             


Ser Lys Cys Pro Gly Tyr Val Ala Thr Thr Thr Thr Pro Thr Thr Thr 
    210                 215                 220                 


Thr Pro Glu Phe Ile Pro Glu Thr Thr Thr Ser Pro Gln Pro Val Ile 
225                 230                 235                 240 


Thr Thr Gln Lys Pro Lys Pro Leu Trp Asn Phe Asn Cys Thr Ser Ile 
                245                 250                 255     


Gln Glu Arg Lys Asn Asp Gly Gly Asp Cys Gly Lys Pro Ala Cys Thr 
            260                 265                 270         


Thr Leu Leu Asn Cys Ala Asn Phe Leu Ser Cys Leu Cys Ser Thr Cys 
        275                 280                 285             


Ala Leu Cys Arg Lys Arg 
    290                 


<210>  58
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  58

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Ala Ser 
                165                 170                 175     


Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Ala Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  59
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  59

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Ser Ile Val 
                165                 170                 175     


Asn Pro His Pro Tyr Gly Gly Val Asp Ala Arg Cys Thr Ser Pro Arg 
            180                 185                 190         


Arg Leu Ala Asn 
        195     


<210>  60
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Ile Val Gln 
                165                 170                 175     


His Ala Ser Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Ala Arg 
            180                 185                 190         


Cys Thr Ser Pro Arg Arg Leu Ala Asn 
        195                 200     


<210>  61
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  61

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Ala Ser 
                165                 170                 175     


Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Ala Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  62
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Ser Ile Val 
                165                 170                 175     


Asn Pro His Pro Tyr Gly Gly Val Asp Ala Arg Cys Thr Ser Pro Arg 
            180                 185                 190         


Arg Leu Ala Asn 
        195     


<210>  63
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  63

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu Ile Val Gln 
                165                 170                 175     


His Ala Ser Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Ala Arg 
            180                 185                 190         


Cys Thr Ser Pro Arg Arg Leu Ala Asn 
        195                 200     


<210>  64
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  64

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Ile Leu Arg Leu Tyr Ile Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Gln 
65                  70                  75                  80  


Leu Val Leu Trp Asp Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gly Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Ala Ser 
                165                 170                 175     


Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Ala Arg Cys Thr 
            180                 185                 190         


Ser Pro Arg Arg Leu Ala Asn 
        195                 


<210>  65
<211>  71
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  Xaa can be any naturally occurring amino acid

<400>  65

Xaa Leu Xaa Leu Xaa Xaa Asn Lys Ile Asn Cys Leu Arg Val Asp Ala 
1               5                   10                  15      


Phe Gln Asp Leu His Asn Leu Asn Xaa Leu Xaa Leu Xaa Xaa Asn Lys 
            20                  25                  30          


Leu Gln Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln 
        35                  40                  45              


Xaa Met Xaa Leu Xaa Xaa Asn Pro Phe Ile Cys Asp Cys His Leu Lys 
    50                  55                  60                  


Trp Leu Ala Asp Tyr Leu His 
65                  70      


<210>  66
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  66

Tyr Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr 
1               5                   10                  15      


Phe Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr 
            20                  25                  30          


<210>  67
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  67

Tyr Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr 
1               5                   10                  15      


Phe Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr 
            20                  25                  30          


Gln 
    


<210>  68
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  68

Tyr Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr 
1               5                   10                  15      


Phe Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln His Met Trp Leu Tyr 
            20                  25                  30          


Gly 
    


<210>  69
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  69

Lys Leu Thr Gln Leu Thr Tyr Leu Asp Leu Asn Asn Asn Gln Leu Lys 
1               5                   10                  15      


Ser Ile Pro Arg Gly Ala Phe Asp Asn Leu Lys Ser Leu Thr His Ile 
            20                  25                  30          


Trp Leu Tyr Gly Asn Pro Trp Asp Cys Glu Cys 
        35                  40              


<210>  70
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  70

Asp Leu His Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln 
1               5                   10                  15      


Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln Thr Met 
            20                  25                  30          


His Leu Ala Gln Asn Pro Phe Ile Cys Asp Cys 
        35                  40              


<210>  71
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Leu His Asn Leu Asn Tyr Leu Asp Leu Asn Asn Asn Lys Leu Gln 
1               5                   10                  15      


Thr Ile Ala Lys Gly Thr Phe Ser Pro Leu Arg Ala Ile Gln His Met 
            20                  25                  30          


Trp Leu Tyr Gln Asn Pro Phe Ile Cys Asp Cys 
        35                  40              


<210>  72
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  72

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
65                  70                  75                  80  


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
        115                 120                 125             


Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
                165                 170                 175     


Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala 
            180                 185                 190         


Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys 
        195                 200                 205     


<210>  73
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Cys Pro Ser Gln Cys Ser Cys Ser Gly Thr Thr Val Asp Cys Arg 
1               5                   10                  15      


Ser Lys Arg His Ala Ser Val Pro Ala Gly Ile Pro Thr Asn Ala Gln 
            20                  25                  30          


Ile Leu Tyr Leu His Asp Asn Gln Ile Thr Lys Leu Glu Pro Gly Val 
        35                  40                  45              


Phe Asp Ser Leu Ile Asn Leu Lys Glu Leu Tyr Leu Gly Ser Asn Gln 
    50                  55                  60                  


Leu Gly Ala Leu Pro Val Gly Val Phe Asp Ser Leu Thr Gln Leu Thr 
65                  70                  75                  80  


Val Leu Asp Leu Gly Thr Asn Gln Leu Thr Val Leu Pro Ser Ala Val 
                85                  90                  95      


Phe Asp Arg Leu Val His Leu Lys Glu Leu Phe Met Cys Cys Asn Lys 
            100                 105                 110         


Leu Thr Glu Leu Pro Arg Gly Ile Glu Arg Leu Thr His Leu Thr His 
        115                 120                 125             


Leu Ala Leu Asp Gln Asn Gln Leu Lys Ser Ile Pro His Gly Ala Phe 
    130                 135                 140                 


Asp Arg Leu Ser Ser Leu Thr His Ala Tyr Leu Phe Gly Asn Pro Trp 
145                 150                 155                 160 


Asp Cys Glu Cys Arg Asp Ile Met Tyr Leu Arg Asn Trp Val Ala Asp 
                165                 170                 175     


His Thr Ser Ile Ala Met Arg Trp Asp Gly Lys Ala Val Asn Asp Pro 
            180                 185                 190         


Asp Ser Ala Lys Cys Ala Gly 
        195                 


<210>  74
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  74

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Ile Leu Arg Leu Tyr Ile Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Gln 
65                  70                  75                  80  


Leu Val Leu Trp Asp Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gly Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His His Ala 
                165                 170                 175     


Ser Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Ala Arg Cys 
            180                 185                 190         


Thr Ser Pro Arg Arg Leu Ala Asn 
        195                 200 


<210>  75
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  75

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Ile Leu Arg Leu Tyr Ile Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Gln 
65                  70                  75                  80  


Leu Val Leu Trp Asp Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gly Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr His 
                165                 170                 175     


Ala Ser Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Arg Cys 
            180                 185                 190         


Thr Ser Pro Arg Arg Leu Ala Asn 
        195                 200 


<210>  76
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  76

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Ile Leu Arg Leu Tyr Ile Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Gln 
65                  70                  75                  80  


Leu Val Leu Trp Asp Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gly Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
                165                 170                 175     


His Ala Ser Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn Ala 
            180                 185                 190         


Arg Cys Thr Ser Pro Arg Arg Leu Ala Asn 
        195                 200         


<210>  77
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  77

Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
1               5                   10                  15      


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
            20                  25                  30          


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
        35                  40                  45              


Ser Pro Tyr Lys Lys Leu Arg Ile Leu Arg Leu Tyr Ile Asn Gln Ile 
    50                  55                  60                  


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Gln 
65                  70                  75                  80  


Leu Val Leu Trp Asp Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
                85                  90                  95      


Glu Gly Leu Phe Ser Leu Gln Leu Leu Tyr Leu Asn Ala Asn Lys Ile 
            100                 105                 110         


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Tyr 
        115                 120                 125             


Leu Asp Leu Asn Asn Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
    130                 135                 140                 


Ser Pro Leu Arg Ala Ile Gln His Ile Trp Leu Tyr Gly Asn Pro Phe 
145                 150                 155                 160 


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
                165                 170                 175     


Pro His Ala Ser Ile Val Asn Pro His Pro Tyr Gly Gly Val Asp Asn 
            180                 185                 190         


Arg Cys Thr Ser Pro Arg Arg Leu Ala Asn 
        195                 200         


<210>  78
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  78

Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu 
1               5                   10          


