                         SEQUENCE LISTING

<110>  CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS 
       (CONICET)
       LABORATORIO PABLO CASSARA SRL
       Baldi, Alberto  	
 
<120>  ANTI-HUMAN VEGF ANTIBODIES WITH UNUSUALLY STRONG BINDING AFINITY 
       TO HUMAN VEGF-A AND CROSS REACTIVITY TO HUMAN VEGF-B

<130>  PCT-801

<150>  US14/267504
<141>  2014-05-01

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  165
<212>  PRT
<213>  homo sapiens

<400>  1

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
        115                 120                 125             


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
    130                 135                 140                 


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
145                 150                 155                 160 


Asp Lys Pro Arg Arg 
                165 


<210>  2
<211>  185
<212>  PRT
<213>  homo sapiens

<400>  2

Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln Arg Lys Val Val Ser 
1               5                   10                  15      


Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln Pro Arg Glu Val Val 
            20                  25                  30          


Val Pro Leu Thr Val Glu Leu Met Gly Thr Val Ala Lys Gln Leu Val 
        35                  40                  45              


Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly Cys Cys Pro Asp Asp 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln Val Arg Met Gln Ile 
65                  70                  75                  80  


Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly Glu Met Ser Leu Glu 
                85                  90                  95      


Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys Lys Asp Ser Ala Val 
            100                 105                 110         


Lys Pro Asp Arg Ala Ala Thr Pro His His Arg Pro Gln Pro Arg Ser 
        115                 120                 125             


Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro Pro Ala Asp Ile Thr 
    130                 135                 140                 


His Pro Thr Pro Ala Pro Gly Pro Ser Ala His Ala Ala Pro Ser Thr 
145                 150                 155                 160 


Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala Ala Ala Ala Asp Ala Ala 
                165                 170                 175     


Ala Ser Ser Val Ala Lys Gly Gly Ala 
            180                 185 


<210>  3
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  3

Gln Val Lys Leu Leu Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Asn Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Thr Ser Val Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  4

Glu Leu Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Phe Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Pro Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Arg 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Phe Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Gly Ser Thr Ser Val Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Phe Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  7

Gly Tyr Thr Phe Thr Asn Phe Gly Met Asn 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  8

Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Val Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  9

Tyr Tyr Gly Ser Thr Ser Val Trp Tyr Phe Asp Val 
1               5                   10          


<210>  10
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  10

Arg Ala Ser Gln Asp Ile Phe Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  11

Tyr Ser Ser Arg Leu His 
1               5       


<210>  12
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  12

Gln Gln Gly Phe Thr Leu Pro Trp Thr 
1               5                   


